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1. Statin Therapy in Ischemic Stroke Patients with Atrial Fibrillation: Efficacy and Safety Outcomes

Author

Marvardi, Michele, primary, Ferrante, Mario, additional, Paciaroni, Maurizio, additional, Abdul-Rahim, Azmil H, additional, Tsivgoulis, Georgios, additional, Seiffge, David J, additional, Engelter, Stefan T, additional, Lyrer, Philippe A., additional, Polymeris, Alexandros A, additional, Dittrich, Tolga D, additional, Cancelloni, Virginia, additional, Zietz, Annaelle, additional, De Marchis, Gian Marco, additional, Putaala, Jukka, additional, Strbian, Daniel, additional, Tomppo, Liisa, additional, Michel, Patrik, additional, Strambo, Davide, additional, Salerno, Alexander, additional, Vanacker, Peter, additional, Zuurbier, Susanna M., additional, Yperzeele, Laetitia, additional, Loos, Caroline MJ, additional, Cappellari, Manuel, additional, Emiliani, Andrea, additional, Zedde, Marialuisa, additional, Becattini, Cecilia, additional, Pascarella, Rosario, additional, Dawson, Jesse, additional, Cronshaw, Robert, additional, Schirinzi, Erika, additional, Del Sette, Massimo, additional, Stretz, Christoph, additional, Kala, Narendra Sharma, additional, Schomer, Ashley, additional, Mac Grory, Brian, additional, Jayaraman, Mahesh V, additional, Yaghi, Shadi, additional, Furie, Karen L., additional, Masotti, Luca, additional, Grifoni, Elisa, additional, Toni, Danilo, additional, Risitano, Angela, additional, Falcou, Anne A, additional, Petraglia, Luca, additional, Lotti, Enrico Maria, additional, Pavolucci, Lucia, additional, Lochner, Piergiorgio, additional, Silvestrelli, Giorgio, additional, Ciccone, Alfonso, additional, Alberti, Andrea, additional, Venti, Michele, additional, Leone De Magistris, Ilaria, additional, Mosconi, Maria Giulia, additional, Giustozzi, Michela, additional, Kargiotis, Odysseas, additional, Rocco, Alessandro, additional, Diomedi, Marina, additional, Marcheselli, Simona, additional, Antonenko, Kateryna, additional, Rota, Eugenia, additional, Tassinari, Tiziana, additional, Saia, Valentina, additional, Palmerini, Francesco, additional, Aridon, Paolo, additional, Arnao, Valentina, additional, Monaco, Serena, additional, Cottone, Salvatore, additional, Baldi, Antonio, additional, D'Amore, Cataldo, additional, Ageno, Walter, additional, Pegoraro, Samuela, additional, Ntaios, George, additional, Adamou, Anastasia, additional, Sagris, Dimitrios, additional, Giannopoulos, Sotirios, additional, Kosmidou, Maria, additional, Ntais, Evangelos, additional, Romoli, Michele, additional, Pantoni, Leonardo, additional, Rosa, Silvia, additional, Bertora, Pierluigi, additional, Chiti, Alberto, additional, Canavero, Isabella, additional, Saggese, Carlo Emanuele, additional, Plocco, Maurizio, additional, Giorli, Elisa, additional, Palaiodimou, Lina, additional, Bakola, Eleni, additional, Bandini, Fabio, additional, Gasparro, Antonio, additional, Terruso, Valeria, additional, Mannino, Marina, additional, Pezzini, Alessandro, additional, Ornello, Raffaele, additional, Sacco, Simona, additional, Popovic, Nemanja, additional, Scoditti, Umberto, additional, Genovese, Antonio, additional, Flomin, Yuriy, additional, Mancuso, Michelangelo, additional, D'agliano, Roberto, additional, Baldini, Marco, additional, Ulivi, Leonardo, additional, Giannini, Nicola, additional, Vadikolias, Konstantinos, additional, Liantinioti, Chrysoula, additional, Chondrogianni, Maria, additional, Halvatsiotis, Panagiotis, additional, Karagkiozi, Efstathia, additional, Athanasakis, George, additional, Makaritsis, Konstantinos, additional, lanari, alessia, additional, Tatlisumak, Turgut, additional, Acciarresi, Monica, additional, Lorenzini, Gianni, additional, Tassi, Rossana, additional, Guideri, Francesca, additional, Acampa, Maurizio, additional, Martini, Giuseppe, additional, Sohn, Sung-Il, additional, Mumoli, Nicola, additional, Cararra, Davide, additional, Maccarrone, Miriam, additional, Galati, Franco, additional, Gourbali, Vanessa, additional, Orlandi, Giovanni, additional, Giuntini, Martina, additional, Corea, Francesco, additional, Bellesini, Marta, additional, Karapanayiotides, Theodore, additional, Csiba, Laszlo, additional, Szabo, Lilla, additional, Imberti, Davide, additional, Pieroni, Alessio, additional, Barlinn, Kristian, additional, Pallesen, Lars-Peder, additional, Barlinn, Jessica, additional, Doronin, Boris, additional, Volodina, Vera Alexandrovna, additional, Agnelli, Giancarlo, additional, Deleu, Dirk, additional, Bonetti, Bruno, additional, Gentile, Luana, additional, Reale, Giuseppe, additional, Caliandro, Pietro, additional, Morotti, Andrea, additional, Vannucchi, Vieri, additional, Padroni, Marina, additional, Letteri, Federica, additional, Magoni, Mauro, additional, Tiseo, Cindy, additional, Rigatelli, Alberto, additional, Zauli, Aurelia, additional, Bossi, Francesco, additional, and Caso, Valeria, additional

Published
2024
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3. Efficacy and Safety of Rescue Treatment with Plasma Exchange in Patients with Acute Inflammatory Neurological Disorders: A Single Center Experience.

Author

Iacono, Salvatore, Schirò, Giuseppe, Salemi, Giuseppe, Scirè, Elisabetta, Aridon, Paolo, Melfa, Michele, Andolina, Michele, Sorbello, Gabriele, Calì, Andrea, Brighina, Filippo, D'Amelio, Marco, and Ragonese, Paolo

Subjects
PLASMA exchange (Therapeutics), NEUROLOGICAL disorders, DISEASE exacerbation, MULTIPLE sclerosis, SYMPTOMS
Abstract

Background: Therapeutic plasma exchange (TPE) is a highly effective rescue treatment for patients with acute exacerbation of neuroimmunological disease that removes circulating autoantibodies and inflammatory components from the bloodstream. The aims of this study are to explore the safety and the effectiveness of TPE in patients with autoimmune neurological disorders. Methods: We retrospectively evaluated the frequency of adverse events (AEs) and the effectiveness of TPE using the modified Ranking Scale (mRS) in patients with acute neurological flares who underwent TPE at the University Hospital of Palermo. Results: Of 59 patients, the majority underwent TPE due to multiple sclerosis (MS) relapse. In 23.7% of cases, TPE was performed before obtaining a definite diagnosis due to the severity of the clinical presentation. After TPE, the mRS score was globally reduced (p < 0.0001), and this effect was marked in patients with MS, Guillain–Barré syndrome, and myasthenia gravis crisis but not in those with paraneoplastic syndromes. Circulating pathogenetic antibodies, younger age, and the early use of TPE were factors strongly associated with TPE effectiveness. The overall safety profile of TPE was satisfactory with an AE frequency of 15%. Conclusions: These results highlight the early use of TPE in patients with circulating pathogenetic antibodies as well as its favorable safety profile. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Risk Factors for Intracerebral Hemorrhage in Patients With Atrial Fibrillation on Non–Vitamin K Antagonist Oral Anticoagulants for Stroke Prevention

Author

Paciaroni, Maurizio, Agnelli, Giancarlo, Giustozzi, Michela, Caso, Valeria, Toso, Elisabetta, Angelini, Filippo, Canavero, Isabella, Micieli, Giuseppe, Antonenko, Kateryna, Rocco, Alessandro, Diomedi, Marina, Katsanos, Aristeidis H., Shoamanesh, Ashkan, Giannopoulos, Sotirios, Ageno, Walter, Pegoraro, Samuela, Putaala, Jukka, Strbian, Daniel, Sallinen, Hanne, Mac Grory, Brian C., Furie, Karen L., Stretz, Christoph, Reznik, Michael E., Alberti, Andrea, Venti, Michele, Mosconi, Maria Giulia, Vedovati, Maria Cristina, Franco, Laura, Zepponi, Giorgia, Romoli, Michele, Zini, Andrea, Brancaleoni, Laura, Riva, Letizia, Silvestrelli, Giorgio, Ciccone, Alfonso, Zedde, Maria Luisa, Giorli, Elisa, Kosmidou, Maria, Ntais, Evangelos, Palaiodimou, Lina, Halvatsiotis, Panagiotis, Tassinari, Tiziana, Saia, Valentina, Ornello, Raffaele, Sacco, Simona, Bandini, Fabio, Mancuso, Michelangelo, Orlandi, Giovanni, Ferrari, Elena, Pezzini, Alessandro, Poli, Loris, Cappellari, Manuel, Forlivesi, Stefano, Rigatelli, Alberto, Yaghi, Shadi, Scher, Erica, Frontera, Jennifer A., Masotti, Luca, Grifoni, Elisa, Caliandro, Pietro, Zauli, Aurelia, Reale, Giuseppe, Marcheselli, Simona, Gasparro, Antonio, Terruso, Valeria, Arnao, Valentina, Aridon, Paolo, Abdul-Rahim, Azmil H., Dawson, Jesse, Saggese, Carlo Emanuele, Palmerini, Francesco, Doronin, Boris, Volodina, Vera, Toni, Danilo, Risitano, Angela, Schirinzi, Erika, Del Sette, Massimo, Lochner, Piergiorgio, Monaco, Serena, Mannino, Marina, Tassi, Rossana, Guideri, Francesca, Acampa, Maurizio, Martini, Giuseppe, Lotti, Enrico Maria, Padroni, Marina, Pantoni, Leonardo, Rosa, Silvia, Bertora, Pierluigi, Ntaios, George, Sagris, Dimitrios, Baldi, Antonio, D’Amore, Cataldo, Mumoli, Nicola, Porta, Cesare, Denti, Licia, Chiti, Alberto, Corea, Francesco, Acciarresi, Monica, Flomin, Yuriy, Popovic, Nemanja, and Tsivgoulis, Georgios

Published
2021
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6. Late seizures in cerebral venous thrombosis

Author

Sánchez van Kammen, Mayte, Lindgren, Erik, Silvis, Suzanne M., Hiltunen, Sini, Heldner, Mirjam Rachel, Serrano, Fabiola, Zelano, Johan, Zuurbier, Susanna M., Mansour, Maryam, Aguiar de Sousa, Diana, Canhão, Patrícia, Al-Asady, Saleem, Ekizoglu, Esme, Redfors, Petra, Yesilot, Nilufer, Ghiasian, Masoud, Barboza, Miguel A., Arnao, Valentina, Aridon, Paolo, Punter, Martin N.M., Ferro, José M., Arauz, Antonio, Tatlisumak, Turgut, Arnold, Marcel, Putaala, Jukka, Jood, Katarina, and Coutinho, Jonathan M.

Published
2020
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7. Acute symptomatic seizures in cerebral venous thrombosis

Author

Lindgren, Erik, Silvis, Suzanne M., Hiltunen, Sini, Heldner, Mirjam R., Serrano, Fabiola, de Scisco, Michele, Zelano, Johan, Zuurbier, Susanna M., Sánchez van Kammen, Mayte, Mansour, Maryam, Aguiar de Sousa, Diana, Penas, Sara, Al-Asady, Saleem, Ekizoglu, Esme, Redfors, Petra, Ahmed, Awet, Yesilot, Nilufer, Ghiasian, Masoud, Barboza, Miguel A., Arnao, Valencia, Aridon, Paolo, Punter, Martin N.M., Ferro, José M., Kleinig, Timothy, Arauz, Antonio, Tatlisumak, Turgut, Arnold, Marcel, Putaala, Jukka, Coutinho, Jonathan M., and Jood, Katarina

Published
2020
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8. COVID-19 and neurological disorders: what might connect Parkinson’s disease to SARS-CoV-2 infection

Author

Iacono, Salvatore, primary, Schirò, Giuseppe, additional, Davì, Chiara, additional, Mastrilli, Sergio, additional, Abbott, Michelle, additional, Guajana, Fabrizio, additional, Arnao, Valentina, additional, Aridon, Paolo, additional, Ragonese, Paolo, additional, Gagliardo, Cesare, additional, Colomba, Claudia, additional, Scichilone, Nicola, additional, and D’Amelio, Marco, additional

Published
2023
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12. A scoring tool to predict mortality and dependency after cerebral venous thrombosis.

Author

Lindgren, Erik, Krzywicka, Katarzyna, de Winter, Maria A., Sánchez Van Kammen, Mayte, Heldner, Mirjam R., Hiltunen, Sini, Aguiar de Sousa, Diana, Mansour, Maryam, Canhão, Patrícia, Ekizoğlu, Esme, Rodrigues, Miguel, Martins Silva, Elisa, Garcia‐Esperon, Carlos, Arnao, Valentina, Aridon, Paolo, Simaan, Naaem Moin, Silvis, Suzanne M., Zuurbier, Susanna M., Scutelnic, Adrian, and Sezgin, Mine

Subjects
CEREBRAL embolism & thrombosis, VENOUS thrombosis, CENTRAL nervous system infections, CEREBRAL hemorrhage, BRAIN death
Abstract

Background and purpose: A prognostic score was developed to predict dependency and death after cerebral venous thrombosis (CVT) to identify patients for targeted therapy in future clinical trials. Methods: Data from the International CVT Consortium were used. Patients with pre‐existent functional dependency were excluded. Logistic regression was used to predict poor outcome (modified Rankin Scale score 3–6) at 6 months and Cox regression to predict 30‐day and 1‐year all‐cause mortality. Potential predictors derived from previous studies were selected with backward stepwise selection. Coefficients were shrunk using ridge regression to adjust for optimism in internal validation. Results: Of 1454 patients with CVT, the cumulative number of deaths was 44 (3%) and 70 (5%) for 30 days and 1 year, respectively. Of 1126 patients evaluated regarding functional outcome, 137 (12%) were dependent or dead at 6 months. From the retained predictors for both models, the SI2NCAL2C score was derived utilizing the following components: absence of female‐sex‐specific risk factor, intracerebral hemorrhage, infection of the central nervous system, neurological focal deficits, coma, age, lower level of hemoglobin (g/l), higher level of glucose (mmol/l) at admission, and cancer. C‐statistics were 0.80 (95% confidence interval [CI] 0.75–0.84), 0.84 (95% CI 0.80–0.88) and 0.84 (95% CI 0.80–0.88) for the poor outcome, 30‐day and 1‐year mortality model, respectively. Calibration plots indicated a good model fit between predicted and observed values. The SI2NCAL2C score calculator is freely available at www.cerebralvenousthrombosis.com. Conclusions: The SI2NCAL2C score shows adequate performance for estimating individual risk of mortality and dependency after CVT but external validation of the score is warranted. [ABSTRACT FROM AUTHOR]

Published
2023
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13. Recurrent Ischemic Stroke and Bleeding in Patients With Atrial Fibrillation Who Suffered an Acute Stroke While on Treatment With Nonvitamin K Antagonist Oral Anticoagulants: The RENO-EXTEND Study

Author

Paciaroni, Maurizio, primary, Caso, Valeria, additional, Agnelli, Giancarlo, additional, Mosconi, Maria Giulia, additional, Giustozzi, Michela, additional, Seiffge, David Julian, additional, Engelter, Stefan T., additional, Lyrer, Philippe, additional, Polymeris, Alexandros A., additional, Kriemler, Lilian, additional, Zietz, Annaelle, additional, Putaala, Jukka, additional, Strbian, Daniel, additional, Tomppo, Liisa, additional, Michel, Patrik, additional, Strambo, Davide, additional, Salerno, Alexander, additional, Remillard, Suzette, additional, Buehrer, Manuela, additional, Bavaud, Odessa, additional, Vanacker, Peter, additional, Zuurbier, Susanna, additional, Yperzeele, Laetitia, additional, Loos, Caroline M.J., additional, Cappellari, Manuel, additional, Emiliani, Andrea, additional, Zedde, Marialuisa, additional, Abdul-Rahim, Azmil, additional, Dawson, Jesse, additional, Cronshaw, Robert, additional, Schirinzi, Erika, additional, Del Sette, Massimo, additional, Stretz, Christoph, additional, Kala, Narendra, additional, Reznik, Michael, additional, Schomer, Ashley, additional, Grory, Brian Mac, additional, Jayaraman, Mahesh, additional, McTaggart, Ryan, additional, Yaghi, Shadi, additional, Furie, Karen L., additional, Masotti, Luca, additional, Grifoni, Elisa, additional, Toni, Danilo, additional, Risitano, Angela, additional, Falcou, Anne, additional, Petraglia, Luca, additional, Lotti, Enrico Maria, additional, Padroni, Marina, additional, Pavolucci, Lucia, additional, Lochner, Piergiorgio, additional, Silvestrelli, Giorgio, additional, Ciccone, Alfonso, additional, Alberti, Andrea, additional, Venti, Michele, additional, Traballi, Laura, additional, Urbini, Chiara, additional, Kargiotis, Odysseas, additional, Rocco, Alessandro, additional, Diomedi, Marina, additional, Marcheselli, Simona, additional, Caliandro, Pietro, additional, Zauli, Aurelia, additional, Reale, Giuseppe, additional, Antonenko, Kateryna, additional, Rota, Eugenia, additional, Tassinari, Tiziana, additional, Saia, Valentina, additional, Palmerini, Francesco, additional, Aridon, Paolo, additional, Arnao, Valentina, additional, Monaco, Serena, additional, Cottone, Salvatore, additional, Baldi, Antonio, additional, D’Amore, Cataldo, additional, Ageno, Walter, additional, Pegoraro, Samuela, additional, Ntaios, George, additional, Sagris, Dimitrios, additional, Giannopoulos, Sotirios, additional, Kosmidou, Maria, additional, Ntais, Evangelos, additional, Romoli, Michele, additional, Pantoni, Leonardo, additional, Rosa, Silvia, additional, Bertora, Pierluigi, additional, Chiti, Alberto, additional, Canavero, Isabella, additional, Saggese, Carlo Emanuele, additional, Plocco, Maurizio, additional, Giorli, Elisa, additional, Palaiodimou, Lina, additional, Bakola, Eleni, additional, Tsivgoulis, Georgios, additional, Bandini, Fabio, additional, Gasparro, Antonio, additional, Terruso, Valeria, additional, Mannino, Marina, additional, Pezzini, Alessandro, additional, Ornello, Raffaele, additional, Sacco, Simona, additional, Popovic, Nemanja, additional, Scoditti, Umberto, additional, Genovese, Antonio, additional, Denti, Licia, additional, Flomin, Yuriy, additional, Mancuso, Michelangelo, additional, Ferrari, Elena, additional, Caselli, Maria Chiara, additional, Ulivi, Leonardo, additional, Giannini, Nicola, additional, and De Marchis, Gian Marco, additional

Published
2022
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18. Vitamin D and Parkinson’s Disease

Author

Pignolo, Antonia, primary, Mastrilli, Sergio, additional, Davì, Chiara, additional, Arnao, Valentina, additional, Aridon, Paolo, additional, dos Santos Mendes, Felipe Augusto, additional, Gagliardo, Cesare, additional, and D’Amelio, Marco, additional

Published
2022
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19. The risk of stroke recurrence in patients with atrial fibrillation and reduced ejection fraction

Author

Paciaroni, Maurizio, Agnelli, Giancarlo, Caso, Valeria, Becattini, Cecilia, Mosconi, Maria Giulia, Giustozzi, Michela, Tsivgoulis, Georgios, Seiffge, David Julian, Engelter, Stefan T., Lyrer, Philippe, Polymeris, Alexandros A., Dittrich, Tolga, Zietz, Annaelle, Putaala, Jukka, Strbian, Daniel, Tomppo, Liisa, Michel, Patrik, Strambo, Davide, Salerno, Alexander, Remillard, Suzette, Buehrer, Manuela, Bavaud, Odessa, Vanacker, Peter, Zuurbier, Susanna M., Yperzeele, Laetitia, Loos, Caroline M.J., Cappellari, Manuel, Emiliani, Andrea, Zedde, Marialuisa, Abdul-Rahim, Azmil H., Dawson, Jesse, Cronshaw, Robert, Schirinzi, Erika, Del Sette, Massimo, Stretz, Christoph, Kala, Narendra, Reznik, Michael, Schomer, Ashley, Mac Grory, Brian, Jayaraman, Mahesh, Yaghi, Shadi, Furie, Karen L., Masotti, Luca, Grifoni, Elisa, Toni, Danilo, Risitano, Angela, Falcou, Anne, Petraglia, Luca, Lotti, Enrico Maria, Padroni, Marina, Pavolucci, Lucia, Lochner, Piergiorgio, Silvestrelli, Giorgio, Ciccone, Alfonso, Alberti, Andrea, Venti, Michele, De Magistris, Ilaria Leone, Cancelloni, Virginia, Kargiotis, Odysseas, Rocco, Alessandro, Diomedi, Marina, Marcheselli, Simona, Caliandro, Pietro, Zauli, Aurelia, Reale, Giuseppe, Moci, Marco, Antonenko, Kateryna, Rota, Eugenia, Tassinari, Tiziana, Saia, Valentina, Palmerini, Francesco, Aridon, Paolo, Arnao, Valentina, Monaco, Serena, Cottone, Salvatore, Baldi, Antonio, D’Amore, Cataldo, Ageno, Walter, Pegoraro, Samuela, Ntaios, George, Sagris, Dimitrios, Giannopoulos, Sotirios, Kosmidou, Maria, Ntais, Evangelos, Romoli, Michele, Pantoni, Leonardo, Rosa, Silvia, Bertora, Pierluigi, Chiti, Alberto, Canavero, Isabella, Saggese, Carlo Emanuele, Plocco, Maurizio, Giorli, Elisa, Palaiodimou, Lina, Bakola, Eleni, Bandini, Fabio, Gasparro, Antonio, Terruso, Valeria, Mannino, Marina, Pezzini, Alessandro, Morotti, Andrea, Magoni, Mauro, Ornello, Raffaele, Sacco, Simona, Popovic, Nemanja, Scoditti, Umberto, Genovese, Antonio, Denti, Licia, Flomin, Yuriy, Mancuso, Michelangelo, Ferrari, Elena, Caselli, Maria Chiara, Ulivi, Leonardo, Giannini, Nicola, Vadikolias, Kostantinos, Liantinioti, Chrysoula, Chondrogianni, Maria, Carletti, Monica, Karagkiozi, Efstathia, Athanasakis, George, Makaritsis, Kostantinos, Lanari, Alessia, Tatlisumak, Turgut, Acciarresi, Monica, Vannucchi, Vieri, Lorenzini, Gianni, Tassi, Rossana, Guideri, Francesca, Acampa, Maurizio, Martini, Giuseppe, Sohn, Sung-Il, Mumoli, Nicola, Tadi, Prasanna, Letteri, Federica, Maccarrone, Miriam, Galati, Franco, Tiseo, Cindy, Gourbali, Vanessa, Halvatsiotis, Panagiotis, Orlandi, Giovanni, Giuntini, Martina, Corea, Francesco, Bellesini, Marta, Baronello, Mario Maimone, Karapanayiotides, Theodore, Rueckert, Christina, Csiba, Laszló, Szabó, Lilla, Rigatelli, Alberto, Imberti, Davide, Zabzuni, Dorjan, Pieroni, Alessio, Barlinn, Kristian, Pallesen, Lars-Peder, Barlinn, Jessica, Doronin, Boris, Volodina, Vera, Deleu, Dirk, Bonetti, Bruno, Porta, Cesare, Gentile, Luana, Eskandari, Ashraf, and De Marchis, Gian Marco

Abstract

Background: Atrial fibrillation (AF) and congestive heart failure often coexist due to their shared risk factors leading to potential worse outcome, particularly cerebrovascular events. The aims of this study were to calculate the rates of ischemic and severe bleeding events in ischemic stroke patients having both AF and reduced ejection fraction (rEF) (⩽40%), compared to ischemic stroke patients with AF but without rEF.Methods: We performed a retrospective analysis that drew data from prospective studies. The primary outcome was the composite of either ischemic (stroke or systemic embolism), or hemorrhagic events (symptomatic intracranial bleeding and severe extracranial bleeding).Results: The cohort for this analysis comprised 3477 patients with ischemic stroke and AF, of which, 643 (18.3%) had also rEF. After a mean follow-up of 7.5 ± 9.1 months, 375 (10.8%) patients had 382 recorded outcome events, for an annual rate of 18.0%. While the number of primary outcome events in patients with rEF was 86 (13.4%), compared to 289 (10.2%) for the patients without rEF; on multivariable analysis rEF was not associated with the primary outcome (OR 1.25; 95% CI 0.84–1.88). At the end of follow-up, 321 (49.9%) patients with rEF were deceased or disabled (mRS ⩾3), compared with 1145 (40.4%) of those without rEF; on multivariable analysis, rEF was correlated with mortality or disability (OR 1.35; 95% CI 1.03–1.77).Conclusions: In patients with ischemic stroke and AF, the presence of rEF was not associated with the composite outcome of ischemic or hemorrhagic events over short-term follow-up but was associated with increased mortality or disability.

Published
2023
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20. Risk of recurrent stroke in patients with atrial fibrillation treated with oral anticoagulants alone or in combination with anti-platelet therapy

Author

Caliandro, Pietro, Cancelloni, Virginia, Marco, Moci, Reale, Giuseppe, Zauli, Aurelia, Agnelli, Giancarlo, Caso, Valeria, Becattini, Cecilia, Calabresi, Paolo, Giulia Mosconi, Maria, Giustozzi, Michela, Tsivgoulis, Georgios, Julian Seiffge, David, Engelter, Stefan T., Lyrer, Philippe, Polymeris, Alexandros A., Dittrich, Tolga, Zietz, Annaelle, Marco De Marchis, Gian, Putaala, Jukka, Strbian, Daniel, Tomppo, Liisa, Michel, Patrik, Strambo, Davide, Salerno, Alexander, Remillard, Suzette, Buehrer, Manuela, Bavaud, Odessa, Vanacker, Peter, Zuurbier, Susanna, Yperzeele, Laetitia, Loos, Caroline M.J., Cappellari, Manuel, Emiliani, Andrea, Zedde, Marialuisa, Abdul-Rahim, Azmil, Dawson, Jesse, Cronshaw, Robert, Schirinzi, Erika, Del Sette, Massimo, Stretz, Christoph, Kala, Narendra, Reznik, Michael, Schomer, Ashley, Mac Grory, Brian, Jayaraman, Mahesh, McTaggart, Ryan, Yaghi, Shadi, Furie, Karen L., Masotti, Luca, Grifoni, Elisa, Toni, Danilo, Risitano, Angela, Falcou, Anne, Petraglia, Luca, Maria Lotti, Enrico, Padroni, Marina, Pavolucci, Lucia, Lochner, Piergiorgio, Silvestrelli, Giorgio, Ciccone, Alfonso, Alberti, Andrea, Venti, Michele, Leone De Magistris, Ilaria, Kargiotis, Odysseas, Rocco, Alessandro, Diomedi, Marina, Marcheselli, Simona, Antonenko, Kateryna, Rota, Eugenia, Tassinari, Tiziana, Saia, Valentina, Palmerini, Francesco, Aridon, Paolo, Arnao, Valentina, Monaco, Serena, Cottone, Salvatore, Baldi, Antonio, D’Amore, Cataldo, Ageno, Walter, Pegoraro, Samuela, Ntaios, George, Sagris, Dimitrios, Giannopoulos, Sotirios, Kosmidou, Maria, Ntais, Evangelos, Romoli, Michele, Pantoni, Leonardo, Rosa, Silvia, Bertora, Pierluigi, Chiti, Alberto, Canavero, Isabella, Emanuele Saggese, Carlo, Plocco, Maurizio, Giorli, Elisa, Palaiodimou, Lina, Bakola, Eleni, Bandini, Fabio, Gasparro, Antonio, Terruso, Valeria, Mannino, Marina, Pezzini, Alessandro, Ornello, Raffaele, Sacco, Simona, Popovic, Nemanja, Scoditti, Umberto, Genovese, Antonio, Denti, Licia, Flomin, Yuriy, Mancuso, Michelangelo, Ferrari, Elena, Chiara Caselli, Maria, Ulivi, Leonardo, Giannini, Nicola, Vadikolias, Kostantinos, Liantinioti, Chrysoula, Chondrogianni, Maria, Halvatsiotis, Panagiotis, Carletti, Monica, Karagkiozi, Efstathia, Athanasakis, George, Makaritsis, Kostantinos, Lanari, Alessia, Tatlisumak, Turgut, Acciarresi, Monica, Vannucchi, Vieri, Lorenzini, Gianni, Tassi, Rossana, Guideri, Francesca, Acampa, Maurizio, Martini, Giuseppe, Sohn, Sung-Il, Mumoli, Nicola, Tadi, Prasanna, Letteri, Federica, Maccarrone, Miriam, Poli, Loris, Magoni, Mauro, Galati, Franco, Tiseo, Cindy, Gourbali, Vanessa, Orlandi, Giovanni, Giuntini, Martina, Corea, Francesco, Bellesini, Marta, Girardi, Laura, Maimone Baronello, Mario, Karapanayiotides, Theodore, Rueckert, Christina, Csiba, Laszló, Szabó, Lilla, Rigatelli, Alberto, Imberti, Davide, Zabzuni, Dorjan, Pieroni, Alessio, Barlinn, Kristian, Pallesen, Lars-Peder, Barlinn, Jessica, Doronin, Boris, Volodina, Vera, Deleu, Dirk, Bonetti, Bruno, Porta, Cesare, Gentile, Luana, Eskandari, Ashraf, and Paciaroni, Maurizio

Abstract

Introduction: Ischaemic stroke patients with atrial fibrillation (AF) are at high risk of stroke recurrence despite oral anticoagulation therapy. Patients with cardiovascular comorbidities may take both antiplatelet and oral anticoagulation therapy (OAC/AP). Our study aims to evaluate the safety and efficacy of OAC/AP therapy as secondary prevention in people with AF and ischaemic stroke.Patients and methods: We performed a post-hoc analysis of pooled individual data from multicenter prospective cohort studies and compared outcomes in the OAC/AP cohort and patients on DOAC/VKA anticoagulation alone (OAC cohort). Primary outcome was a composite of ischaemic stroke, systemic embolism, intracranial bleeding, and major extracranial bleeding, while secondary outcomes were ischaemic and haemorrhagic events considered separately. A multivariable logistic regression analysis was performed to identify independent predictors for outcome events. To compare the risk of outcome events between the two cohorts, the relation between the survival function and the set of explanatory variables were calculated by Cox proportional hazard models and the results were reported as adjusted hazard ratios (HR). Finally another analysis was performed to compare the overall risk of outcome events in both OAC/AP and OAC cohorts after propensity score matching (PSM).Results: During a mean follow-up time of 7.5 ± 9.1 months (median follow-up time 3.5 months, interquartile range ±3), 2284 stroke patients were on oral anticoagulants and 215 were on combined therapy. The multivariable model demonstrated that the composite outcome is associated with age (OR: 1.03, 95% CI: 1.01–1.04 for each year increase) and concomitant antiplatelet therapy (OR: 2.2, 95% CI: 1.48–3.27), the ischaemic outcome with congestive heart failure (OR: 1.55, 95% CI: 1.02–2.36) and concomitant antiplatelet therapy (OR: 1.93, 95% CI: 1.19–3.13) and the haemorrhagic outcome with age (OR: 1.03, 95% CI: 1.01–1.06 for each year increase), alcoholism (OR: 2.15, 95% CI: 1.06–4.39) and concomitant antiplatelet therapy (OR: 2.22, 95% CI: 1.23–4.02). Cox regression demonstrated a higher rate of the composite outcome (hazard ratio of 1.93 [95% CI, 1.35–2.76]), ischaemic events (HR: 2.05 [95% CI: 1.45–2.87]) and bleeding outcomes (HR: 1.90 [95% CI, 1.06–3.40]) in OAC/AP cohort. After PSM analysis, the composite outcome remained more frequent in people treated with OAC + AP (RR: 1.70 [95% CI, 1.05–2.74]).Discussion: Secondary prevention with combination of oral anticoagulant and antiplatelet therapy after ischaemic stroke was associated with worse outcomes in our cohort.Conclusion: Further research is needed to improve secondary prevention by investigating the mechanisms of recurrent ischaemic stroke in patients with atrial fibrillation.

Published
2023
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23. Risk factors for intracerebral hemorrhage in patients with atrial fibrillation on NOACs for stroke prevention

Author

Paciaroni, Maurizio, Agnelli, Giancarlo, Giustozzi, Michela, Caso, Valeria, Toso, Elisabetta, Angelini, Filippo, Canavero, Isabella, Micieli, Giuseppe, Antonenko, Kateryna, Rocco, Alessandro, Diomedi, Marina, Katsanos, Aristeidis H., Shoamanesh, Ashkan, Giannopoulos, Sotirios, Ageno, Walter, Pegoraro, Samuela, Putaala, Jukka, Strbian, Daniel, Sallinen, Hanne, Mac Grory, Brian C., Furie, Karen L., Stretz, Christoph, Reznik, Michael, Alberti, Andrea, Venti, Michele, Mosconi, Maria Giulia, Vedovati, Maria Cristina, Franco, Laura, Zepponi, Giorgia, Romoli, Michele, Zini, Andrea, Brancaleoni, Laura, Riva, Letizia, Silvestrelli, Giorgio, Ciccone, Alfonso, Zedde, Maria Luisa, Giorli, Elisa, Kosmidou, Maria, Ntais, Evangelos, Palaiodimou, Lina, Halvatsiotis, Panagiotis, Tassinari, Tiziana, Saia, Valentina, Ornello, Raffaele, Sacco, Simona, Bandini, Fabio, Mancuso, Michelangelo, Orlandi, Giovanni, Ferrari, Elena, Pezzini, Alessandro, Poli, Loris, Cappellari, Manuel, Forlivesi, Stefano, Rigatelli, Alberto, Yaghi, Shadi, Scher, Erica, Frontera, Jennifer A., Masotti, Luca, Grifoni, Elisa, Caliandro, Pietro, Zauli, Aurelia, Reale, Giuseppe, Marcheselli, Simona, Gasparro, Antonio, Terruso, Valeria, Arnao, Valentina, Aridon, Paolo, Abdul-Rahim, Azmil, Dawson, Jesse, Saggese, Carlo Emanuele, Palmerini, Francesco, Doronin, Boris, Volodina, Vera, Toni, Danielo, Risitano, Angela, Schirinzi, Erika, Del Sette, Massimo, Lochner, Piergiorgio, Monaco, Serena, Mannino, Marina, Tassi, Rossana, Guideri, Francesca, Acampa, Maurizio, Martini, Giuseppe, Lotti, Enrico Maria, Padroni, Marina, Pantoni, Leonardo, Rosa, Silvia, Bertora, Pierluigi, Ntaios, George, Sagris, Dimitrios, Baldi, Antonio, D’Amore, Cataldo, Mumoli, Nicola, Porta, Cesare, Denti, Licia, Licia, Alberto, Corea, Francesco, Acciarresi, Monica, Flomin, Yuriy, Popovic, Nemanja, and Tsivgoulis, Georgios

Subjects
cardiovascular diseases
Abstract

Background and Purpose:\ud Clinical trials on stroke prevention in patients with atrial fibrillation have consistently shown clinical benefit from either warfarin or non–vitamin K antagonist oral anticoagulants (NOACs). NOAC-treated patients have consistently reported to be at lower risk for intracerebral hemorrhage (ICH) than warfarin-treated patients. The aims of this prospective, multicenter, multinational, unmatched, case-control study were (1) to investigate for risk factors that could predict ICH occurring in patients with atrial fibrillation during NOAC treatment and (2) to evaluate the role of CHA2DS2-VASc and HAS-BLED scores in the same setting.\ud \ud Methods:\ud Cases were consecutive patients with atrial fibrillation who had ICH during NOAC treatment. Controls were consecutive patients with atrial fibrillation who did not have ICH during NOAC treatment. As within the CHA2DS2-VASc and HAS-BLED scores there are some risk factors in common, several multivariable logistic regression models were performed to identify independent prespecified predictors for ICH events.\ud \ud Results:\ud Four hundred nineteen cases (mean age, 78.8±8.1 years) and 1526 controls (mean age, 76.0±10.3 years) were included in the study. From the different models performed, independent predictors of ICH were increasing age, concomitant use of antiplatelet agents, active malignancy, high risk of fall, hyperlipidemia, low clearance of creatinine, peripheral artery disease, and white matter changes. Low doses of NOACs (given according to label or not) and congestive heart failure were inversely associated with the risk of ICH. HAS-BLED and CHA2DS2-VASc scores performed poorly in predicting ICH with areas under the curves of 0.496 (95% CI, 0.468-0.525) and 0.530 (95% CI, 0.500-0.560), respectively.\ud \ud Conclusions:\ud Several risk factors were associated to ICH in patients treated with NOACs for stroke prevention but not HAS-BLED and CHA2DS2-VASc scores.

Published
2021

27. Statin therapy in ischemic stroke patients with atrial fibrillation: Efficacy and safety outcomes

Author

Marvardi, Michele, Paciaroni, Maurizio, Caso, Valeria, Marvardi, Michele, Ferrante, Mario, Abdul-Rahim, Azmil, Georgios Tsivgoulis, MD, Julian Seiffge, David, Engelter, Stefan T., Lyrer, Philippe, Polymeris, Alexandros A., Dittrich, Tolga, Cancelloni, Virginia, Zietz, Annaelle, Marco De Marchis, Gian, Putaala, Jukka, Strbian, Daniel, Tomppo, Liisa, Michel, Patrik, Strambo, Davide, Salerno, Alexander, Vanacker, Peter, Zuurbier, Susanna, Yperzeele, Laetitia, Loos, Caroline M.J., Cappellari, Manuel, Emiliani, Andrea, Zedde, Marialuisa, Becattini, Cecilia, Pascarella, Rosario, Dawson, Jesse, Cronshaw, Robert, Schirinzi, Erika, Del Sette, Massimo, Stretz, Christoph, Kala, Narendra, Schomer, Ashley, Mac Grory, Brian, Jayaraman, Mahesh, Yaghi, Shadi, Furie, Karen L., Masotti, Luca, Grifoni, Elisa, Toni, Danilo, Risitano, Angela, Falcou, Anne, Petraglia, Luca, Maria Lotti, Enrico, Pavolucci, Lucia, Lochner, Piergiorgio, Silvestrelli, Giorgio, Ciccone, Alfonso, Alberti, Andrea, Venti, Michele, Leone De Magistris, Ilaria, Giulia Mosconi, Maria, Giustozzi, Michela, Kargiotis, Odysseas, Rocco, Alessandro, Diomedi, Marina, Marcheselli, Simona, Antonenko, Kateryna, Rota, Eugenia, Tassinari, Tiziana, Saia, Valentina, Palmerini, Francesco, Aridon, Paolo, Arnao, Valentina, Monaco, Serena, Cottone, Salvatore, Baldi, Antonio, D’Amore, Cataldo, Ageno, Walter, Pegoraro, Samuela, Ntaios, George, Adamou, Anastasia, Sagris, Dimitrios, Giannopoulos, Sotirios, Kosmidou, Maria, Ntais, Evangelos, Romoli, Michele, Pantoni, Leonardo, Rosa, Silvia, Bertora, Pierluigi, Chiti, Alberto, Canavero, Isabella, Emanuele Saggese, Carlo, Plocco, Maurizio, Giorli, Elisa, Palaiodimou, Lina, Bakola, Eleni, Bandini, Fabio, Gasparro, Antonio, Terruso, Valeria, Mannino, Marina, Pezzini, Alessandro, Ornello, Raffaele, Sacco, Simona, Popovic, Nemanja, Scoditti, Umberto, Genovese, Antonio, Flomin, Yuriy, Mancuso, Michelangelo, D’Agliano, Roberto, Baldini, Marco, Ulivi, Leonardo, Giannini, Nicola, Vadikolias, Kostantinos, Liantinioti, Chrysoula, Chondrogianni, Maria, Halvatsiotis, Panagiotis, Karagkiozi, Efstathia, Athanasakis, George, Makaritsis, Kostantinos, Lanari, Alessia, Tatlisumak, Turgut, Acciarresi, Monica, Lorenzini, Gianni, Tassi, Rossana, Guideri, Francesca, Acampa, Maurizio, Martini, Giuseppe, Sohn, Sung-Il, Mumoli, Nicola, Carrara, Davide, Maccarrone, Miriam, Galati, Franco, Gourbali, Vanessa, Orlandi, Giovanni, Giuntini, Martina, Corea, Francesco, Bellesini, Marta, Karapanayiotides, Theodore, Csiba, Laszló, Szabó, Lilla, Imberti, Davide, Pieroni, Alessio, Barlinn, Kristian, Pallesen, Lars-Peder, Barlinn, Jessica, Doronin, Boris, Volodina, Vera, Agnelli, Giancarlo, Deleu, Dirk, Bonetti, Bruno, Gentile, Luana, Reale, Giuseppe, Caliandro, Pietro, Morotti, Andrea, Vannucchi, Vieri, Padroni, Marina, Letteri, Federica, Magoni, Mauro, Tiseo, Cindy, Rigatelli, Alberto, Zauli, Aurelia, Bossi, Francesco, Paciaroni, Maurizio, and Caso, Valeria

Abstract

Introduction: The efficacy and safety of statins for secondary prevention in patients who have experienced a cardioembolic stroke are not well-defined. However, previous observational data reported hyperlipidemia as a risk factor for both ischemic and bleeding complications in patients with AF and previous stroke. Based on these premises, we conducted a sub-analysis of the RAF and RAF-NOAC studies to evaluate the efficacy and safety of statins in secondary prevention in patients with acute ischemic stroke and AF.Materials and methods: We combined patient data from the RAF and RAF-NOAC studies, prospective observational studies conducted across Stroke Units in Europe, the United States, and Asia from January 2012 to June 2016. We included consecutive patients with AF who suffered an acute ischemic stroke with a follow-up of 90 days. Our outcomes were the combined endpoint, including stroke, transient ischemic attack, systemic embolism, symptomatic intracerebral hemorrhage, and major extracranial bleeding. Furthermore, both ischemic and hemorrhagic outcomes were evaluated separately.Results: A total of 1742 patients were included (46% male), and 898 (52%) received statins after the index event, of whom 436 (48.6%) were already taking statins before the index event, 462 (51.4%) started treatment after. At multivariable analysis, statin use was statistically associated with age (OR 0.92, 95% CI 0.97–0.99, p= 0.001), male sex (OR 1.35, 95% CI 1.07–1.70, p= 0.013), anticoagulation (OR 2.53, 95% CI 1.90–3.36, p< 0.0001), hyperlipidemia (OR 5.52, 95% CI 4.28–7.12, p< 0.0001), paroxysmal AF (OR 1.40, 95% CI 1.12–1.75, p= 0.003), leukoaraiosis (OR 1.39, 95% CI 1.11–1.75, p= 0.004) and heart failure (OR 0.72, 95% CI 0.53–0.98, p= 0.034). Statin use was not associated with the combined outcome event (OR 0.84, 95% CI 0.58–1.23, p= 0.3) and ischemic outcome event (OR 1.17, 95% CI 0.73–1.88, p= 0.5) while was associated with a lower risk of hemorrhagic outcome event (OR 0.51, 95% CI 0.28–0.91, p= 0.02).Discussion: Statins protect cerebral arterial vessels (particularly small vessels) from subacute damage due to hypertension, diabetes, and other harmful agents (such as reactive oxygen species, proinflammatory cytokines, etc.) due to their systemic anti-inflammatory and endothelium-protective effects.Conclusions: Our data show that statins seem to protect against global bleeding events in cardioembolic stroke patients; this may be due to the pleiotropic effect of statins. More data are warranted to confirm these findings.

Published
2025
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28. Increased sensitivity of the neuronal nicotinic receptor alpha2 subunit causes familial epilepsy with nocturnal wandering and ictal fear

Author

Aridon, Paolo, Marini, Carla, Di Resta, Chiara, Brilli, Elisa, De Fusco, Maurizio, Politi, Fausta, Parrini, Elena, Manfredi, Irene, Pisano, Tiziana, Pruna, Dario, Curia, Giulia, Cianchetti, Carlo, Pasqualetti, Massimo, Becchetti, Andrea, Guerrini, Renzo, and Casari, Giorgio

Subjects
Nicotinic receptors -- Research, Gene mutations -- Research, Epilepsy -- Genetic aspects, Genetic research, Biological sciences
Abstract

A clinical and molecular genetic study of the large pedigree segregating sleep-related epilepsy is performed where the seizures are associated with fear sensation, tongue movements, and nocturnal wandering, closely resembling nightmares and sleep walking. The positional candidate neuronal cholinergic receptor alpha2 subunit gene (CHRNA2) is the third neuronal cholinergic receptor gene to be associated with familial sleep-related epilepsies and the CHRNA2 mutations are found to cause a more complex and finalized ictal behavior.

Published
2006

33. Reduced Admissions for Cerebrovascular Events During COVID-19 Outbreak in Italy

Author

Sacco, Simona, primary, Ricci, Stefano, additional, Ornello, Raffaele, additional, Eusebi, Paolo, additional, Petraglia, Luca, additional, Toni, Danilo, additional, Rota, Eugenia, additional, Bruzzone, Gianluca, additional, Testa, Lucia, additional, Bongioanni, Roberta, additional, Rosso, Mara, additional, Labate, Carmelo, additional, Tarletti, Roberto, additional, Cantello, Roberto, additional, Fleetwood, Thomas, additional, Melis, Fabio, additional, Imperiale, Daniele, additional, Amarù, Salvatore, additional, Reggiani, Monica, additional, Ruiz, Luigi, additional, Cipriano, Elia, additional, Ferrandi, Delfina, additional, Julita, Patrizia, additional, Africa, Liana, additional, Meinieri, Piero, additional, Grasso, Maria Federica, additional, Servo, Serena, additional, Cavallo, Roberto, additional, Chianale, Gigliola, additional, Naldi, Andrea, additional, Cerrato, Paolo, additional, Rubino, Elisa, additional, Giossi, Alessia, additional, Puglisi, Valentina, additional, Vinciguerra, Luisa, additional, Santilli, Ignazio, additional, Bordo, Bianca Maria, additional, Marcheselli, Simona, additional, Bottini, Julia, additional, D’Alessandro, Caterina Mariotto, additional, Micieli, Giuseppe, additional, Cavallini, Anna, additional, Canavero, Isabella, additional, Muscia, Francesco, additional, Nuzzaco, Graziamaria, additional, Ciccone, Alfonso, additional, Silvestrelli, Giorgio, additional, Salmaggi, Andrea, additional, Sangalli, Davide, additional, Zanferrari, Carla, additional, Fanucchi, Simona, additional, Ranieri, Michela, additional, Beretta, Simone, additional, Ferrarese, Carlo, additional, Pasini, Francesco, additional, Santangelo, Francesco, additional, Checcarelli, Nicoletta, additional, Beretta, Sandro, additional, Bazzi, Paola, additional, Camerlingo, Massimo, additional, Tognozzi, Marcello, additional, Caneve, Giorgio, additional, Adami, Alessandro, additional, Quatrale, Rocco, additional, Critelli, Adriana, additional, Bartolomei, Luigi, additional, Masato, Maela, additional, Perini, Francesco, additional, De Boni, Antonella, additional, Disco, Caterina, additional, Baracchini, Claudio, additional, Pieroni, Alessio, additional, Lerario, Roberto, additional, Russo, Monia, additional, Polo, Alberto, additional, Danese, Alessandra, additional, Valentinis, Luca, additional, Baldi, Antonio, additional, Tonello, Simone, additional, Paladin, Francesco, additional, Tonon, Agnese, additional, Bonetti, Bruno, additional, Cappellari, Manuel, additional, Teatini, Francesco, additional, Dossi, Roberto Currò, additional, Franchini, Enrica, additional, Giometto, Bruno, additional, Bignamini, Valeria, additional, Manganotti, Paolo, additional, Naccarato, Marcello, additional, Gigli, Gian Luigi, additional, Lorenzut, Simone, additional, Merlino, Giovanni, additional, Valente, Mariarosaria, additional, Rana, Michele, additional, Gentile, Carolina, additional, Tassinari, Tiziana, additional, Sugo, Annalisa, additional, Saia, Valentina, additional, Balestrino, Maurizio, additional, Coccia, Alberto, additional, Finocchi, Cinzia, additional, Valzania, Franco, additional, Zedde, Maria Luisa, additional, Toschi, Giulia, additional, Longoni, Marco, additional, Paolucci, Matteo, additional, Tugnoli, Valeria, additional, Querzani, Pietro, additional, Padroni, Marina, additional, Meletti, Stefano, additional, Bigliardi, Guido, additional, Dall’Acqua, Maria Luisa, additional, Zini, Andrea, additional, Gentile, Mauro, additional, Migliaccio, Ludovica, additional, Chiti, Alberto, additional, Tassi, Rossana, additional, Martini, Giuseppe, additional, Nencini, Patrizia, additional, Lamassa, Maria, additional, Mancuso, Michelangelo, additional, Orlandi, Giovanni, additional, Ferrari, Elena, additional, Marconi, Roberto, additional, Gallerini, Simone, additional, Groggia, Vincenzo, additional, Volpi, Gino, additional, Menichetti, Chiara, additional, Spolveri, Stefano, additional, Silvestrini, Mauro, additional, Viticchi, Giovanna, additional, Buratti, Laura, additional, Pelliccioni, Giuseppe, additional, Potente, Eleonora, additional, Mazzoli, Tatiana, additional, Marsili, Erica, additional, Cenciarelli, Silvia, additional, Picchioni, Antonella, additional, Costantini, Franco, additional, Colosimo, Carlo, additional, Paciaroni, Maurizio, additional, Caso, Valeria, additional, Rasura, Maurizia, additional, Beccia, Mario, additional, Falcone, Nicola, additional, Di Stefano, Marisa, additional, Cecconi, Emanuela, additional, Anticoli, Sabrina, additional, Pezzella, Francesca Romana, additional, Mangiardi, Marilena, additional, Plocco, Maurizio, additional, Magarelli, Maria, additional, Saggese, Carlo Emanuele, additional, Berto, Irene, additional, Altavista, Maria Concetta, additional, Roberti, Cinzia, additional, Diomedi, Marina, additional, Sallustio, Fabrizio, additional, Rocco, Alessandro, additional, Cupini, Letizia Maria, additional, Bonaffini, Novella, additional, De Angelis, Maria Vittoria, additional, Digiovanni, Anna, additional, Rispoli, Marianna, additional, Orlandi, Berardino, additional, Santis, Federica De, additional, Colangeli, Enrico, additional, Blasio, Francesco Di, additional, Carmine, Caterina Di, additional, Tocco, Pierluigi, additional, Melis, Maurizio, additional, Moller, Jessica, additional, Saddi, Valeria, additional, Manca, Antonio, additional, Baule, Antonio, additional, Caddeo, Antonello, additional, Iorio, Nicola, additional, Napoletano, Rosa, additional, di Gregorio, Maria, additional, Volpe, Giampiero, additional, D’Onofrio, Florindo, additional, Spitaleri, Daniele, additional, Barbarini, Leonardo, additional, Barbagallo, Gaetano, additional, Caggiula, Marcella, additional, Ardito, Bonaventura, additional, Noia, Domenico Di, additional, Viesti, Pietro Di, additional, Leone, Maurizio Angelo, additional, Inchingolo, Vincenzo, additional, Petruzzellis, Marco, additional, Rizzo, Federica, additional, Savarese, Mariantonietta, additional, Petrone, Alfredo, additional, Galati, Franco, additional, Arcudi, Luciano, additional, Branca, Damiano, additional, Aridon, Paolo, additional, Arnao, Valentina, additional, Musolino, Rosa, additional, Dell’Aera, Cristina, additional, Francalanza, Isabella, additional, Grimaldi, Luigi, additional, Gammino, Matilde, additional, Giordano, Antonello, additional, Zelante, Giuseppe, additional, Sanzaro, Enzo, additional, and Gasparro, Antonio, additional

Published
2020
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38. Identification of a new locus for medullary cystic disease, on chromosome 16p12

Author

Scolari, Francesco, Puzzer, Daniela, Amoroso, Antonio, Caridi, Gianluca, Ghiggeri, Gian Marco, Maiorca, Rosario, Aridon, Paolo, De Fusco, Maurizio, Ballabio, Andrea, and Casari, Giorgio

Subjects
Kidney, Cystic -- Genetic aspects, Kidney diseases -- Genetic aspects, Biological sciences
Abstract

A novel locus for autosomal dominant medullary cystic disease (ADMCKD) has been identified through study of an Italian pedigree covering four generations. The locus is on chromosome 16p12, within a critical region of 10.5 cM between D16S500 and SCNN1B1-2. Genetic heterogeneity of the disorder has been established, despite its clinical homogeneity.

Published
1999

42. Linkage Analysis and Disease Models in Benign Familial Infantile Seizures: A Study of 16 Families

Author

Striano, Pasquale, Lispi, Maria Luisa, Gennaro, Elena, Madia, Francesca, Traverso, Monica, Bordo, Laura, Aridon, Paolo, Boneschi, Filippo Martinelli, Barone, Baldassare, Bernardina, Bernardo dalla, Bianchi, Amedeo, Capovilla, Giuseppe, De Marco, Pasquale, Dulac, Olivier, Gaggero, Roberto, Gambardella, Antonio, Nabbout, Rima, Prudʼhomme, Jean-François, Day, Ruth, Vanadia, Francesca, Vecchi, Marilena, Veggiotti, Pierangelo, Vigevano, Federico, Viri, Maurizio, Minetti, Carlo, and Zara, Federico

Published
2006

47. A whole genome screen for linkage disequilibrium in multiple sclerosis performed in a continental Italian population

Author

Liguori, Maria, Sawcer, Stephen, Setakis, Efrosini, Compston, Alastair, Giordano, Mara, D'Alfonso, Sandra, Mellai, Marta, Malferrari, Giulia, Trojano, Maria, Livrea, Paolo, De Robertis, Francesca, Massacesi, Luca, Repice, Anna, Ballerini, Clara, Biagioli, Tiziana, Bomprezzi, Roberto, Cannoni, Stefania, Ristori, Giovanni, Salvetti, Marco, Grimaldi, Luigi M.E., Biunno, Ida, Comi, Giancarlo, Leone, Maurizio, Ferro, Isabella, Naldi, Paola, Milanese, Clara, Gellera, Cinzia, Loredana, La Mantia, Savettieri, Giovanni, Salemi, Giuseppe, Aridon, Paolo, Caputo, Domenico, Rosa Guerini, Franca, Ferrante, Pasquale, and Momigliano-Richiardi, Patricia

Published
2003
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48. TBC1D24-TLDc-related epilepsy exercise-induced dystonia: rescue by antioxidants in a disease model

Author

Lüthy, Kevin, primary, Mei, Davide, additional, Fischer, Baptiste, additional, De Fusco, Maurizio, additional, Swerts, Jef, additional, Paesmans, Jone, additional, Parrini, Elena, additional, Lubarr, Naomi, additional, Meijer, Inge A, additional, Mackenzie, Katherine M, additional, Lee, Wang-Tso, additional, Cittaro, Davide, additional, Aridon, Paolo, additional, Schoovaerts, Nils, additional, Versées, Wim, additional, Verstreken, Patrik, additional, Casari, Giorgio, additional, and Guerrini, Renzo, additional

Published
2019
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50. Late seizures in cerebral venous thrombosis.

Author

van Kammen, Mayte Sánchez, Lindgren, Erik, Silvis, Suzanne M., Hiltunen, Sini, Heldner, Mirjam Rachel, Serrano, Fabiola, Zelano, Johan, Zuurbier, Susanna M., Mansour, Maryam, Aguiar de Sousa, Diana, Canhão, Patrícia, Al-Asady, Saleem, Ekizoglu, Esme, Redfors, Petra, Yesilot, Nilufer, Ghiasian, Masoud, Barboza, Miguel A., Arnao, Valentina, Aridon, Paolo, and Punter, Martin N.M.

Published
2020
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