1. The effects of apelin treatment on a rat model of type 2 diabetes
- Author
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Raziye Akcılar, T. Olgun Özcan, Vildan Caner, Aydın Akcılar, Levent Elmas, Sebahat Turgut, and Ceylan Ayada
- Subjects
Male ,blood pressure measurement ,medicine.medical_treatment ,insulin blood level ,Blood Pressure ,Type 2 diabetes ,angiotensin II ,Wistar rat ,Receptors, G-Protein-Coupled ,molecular pathology ,renin angiotensin aldosterone system ,Alloxan ,Insulin ,Glucose homeostasis ,rat ,animal ,genetics ,glucose ,pyroglutamylated apelin 13 ,Apelin Receptors ,Glucose metabolism ,vascular tissue ,messenger RNA ,non insulin dependent diabetes mellitus ,General Medicine ,Apelin ,Apelin receptor (APJ) ,Type II diabetes ,Glucose ,apelin receptor ,unclassified drug ,apelin ,antidiabetic activity ,real time polymerase chain reaction ,Animals ,Blood Pressure/drug effects ,Diabetes Mellitus, Type 2/*blood/*drug therapy/metabolism ,Hypoglycemic Agents/metabolism/therapeutic use ,Insulin/blood ,Intercellular Signaling Peptides and Proteins/genetics/metabolism/*therapeutic use ,RNA, Messenger/metabolism ,Rats ,Rats, Wistar ,Receptors, G-Protein-Coupled/genetics ,Intercellular Signaling Peptides and Proteins ,angiotensin blood level ,heart weight ,medicine.medical_specialty ,APLNR protein, human ,APLN protein, human ,animal experiment ,Adipokine ,G protein coupled receptor ,heart ,Article ,animal tissue ,peptide derivative ,body weight ,blood ,Diabetes mellitus ,Internal medicine ,medicine ,Hypoglycemic Agents ,endothelin 1 ,signal peptide ,controlled study ,RNA, Messenger ,Autocrine signalling ,Apelin receptor ,nonhuman ,business.industry ,animal model ,antidiabetic agent ,medicine.disease ,enzyme linked immunosorbent assay ,angiotensinogen ,glucose blood level ,Endocrinology ,Diabetes Mellitus, Type 2 ,protein blood level ,drug effects ,gene expression ,business ,metabolism ,Blood pressure - Abstract
Purpose: Apelin is an adipokine that plays a role in the regulation of many biological functions in mammals including the neuroendocrine, cardiovascular, immune systems, glucose homeostasis and obesity. It can act via autocrine, paracrine, endocrine, and exocrine signaling. We aimed to identify the role of apelin pathophysiology of diabetes. Material/methods: 37 male Wistar Albino rats aged 8-10 weeks were divided in four experimental groups as: control group (C) control + apelin group (C + A), diabetic group (D) diabetic + apelin group (D + A). Apelin and apelin receptor mRNA gene expressions in heart and aorta tissue were determined by real-time polymerase chain reaction. The plasma levels of insulin and plasma apelin were determined by ELISA. Results Plasma levels of insulin, glucose, blood pressure levels were significantly lower in D + A group. There was no statistically significant difference for level of apelin between diabetic groups. On the other hand, differences for apelin and APJ mRNA expression in heart and vascular tissue were found significant between groups. Conclusions: Apelin can be used as a therapeutic agent in the treatment of type II diabetes in the future. © 2014 Medical University of Bialystok., 2011 SBE001, This study was supported by Pamukkale University Research Fund (Project No.: 2011 SBE001).
- Published
- 2015