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A study conducted in Asia examined the real-world usage, effectiveness, and safety of oral tramadol/dexketoprofen trometamol fixed-dose combination (TRAM/DKP FDC) in treating moderate-to-severe acute pain. The research involved 599 adult patients across multiple countries and found that TRAM/DKP FDC effectively reduced pain intensity, with 65% of patients experiencing a 30% pain reduction at 8 hours post the first dose. The majority of patients were satisfied with the treatment, and adverse drug reactions were reported in 13.9% of patients, mostly being mild to moderate in severity. The study concluded that TRAM/DKP FDC was well-tolerated and effective in diverse types of patients in the real-world setting in Asia. [Extracted from the article]

A recent study conducted by researchers at the University of South Florida analyzed data from the FDA Adverse Event Reporting System (FAERS) to investigate the relationship between triptans (sumatriptan, rizatriptan, and zolmitriptan) and cardiovascular adverse events in migraine treatment. The study found that women reported more cardiovascular adverse events with rizatriptan and zolmitriptan compared to men, and individuals aged 18-64 had the highest risk. Sumatriptan was associated with a higher cardiovascular risk than rizatriptan and zolmitriptan, with most deaths and serious cases documented for sumatriptan. This research may help in evaluating the risk of triptan treatment for migraines. [Extracted from the article]

Researchers from the University of Szeged in Hungary have conducted a study on meloxicam therapy, focusing on the formulation of nasal powders containing meloxicam potassium monohydrate. The study aimed to enhance drug permeation through the nasal mucosa by using different excipients such as cyclodextrin and polyvinyl alcohol. Results showed that charged cyclodextrin-based formulations improved drug adhesivity and release, with the anionic cyclodextrin enhancing drug permeation. This research provides valuable insights into the development of nasal drug delivery systems for anti-inflammatory agents like meloxicam. [Extracted from the article]

A recent study conducted by researchers from the Ministry of AYUSH focused on the anti-arthritic activity of Trayodashang guggulu (TG), a classical Ayurvedic formulation, against rheumatoid arthritis in rats. The study aimed to evaluate the effects of TG on arthritis induced in Wistar rats and found that TG reversed the arthritis symptoms and reduced serum biochemical markers similar to ibuprofen. This research opens up avenues for further exploration into the specific mechanisms of action of TG in treating rheumatoid arthritis. [Extracted from the article]

A study conducted at National Taiwan University Hospital focused on the real-world use of Pirfenidone in patients with Idiopathic Pulmonary Fibrosis (IPF) in Taiwan. The study included 50 IPF patients, mostly men with a mean age of 72.8 years, and found that Pirfenidone stabilized forced vital capacity (FVC) and cough symptoms in most patients. The research concluded that Pirfenidone is an effective, safe, and well-tolerated treatment for IPF in Taiwan. [Extracted from the article]

The article discusses a randomized controlled trial comparing the effect of a combined ketorolac and lidocaine paracervical block with a standard lidocaine paracervical block on procedure-related pain during office hysteroscopies. The trial aims to study the impact of the combined block on pain, patient satisfaction, and adverse events. It involves female patients undergoing office hysteroscopies at Mount Sinai Hospital and aims to determine if adding ketorolac to the paracervical block reduces pain. The study is set to be conducted over two years with a total enrollment of 44 participants. [Extracted from the article]

A recent study conducted by the Department of Orthopaedic Surgery found that regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen, and celecoxib increases the risk of stress fractures in the general population. The research surveyed individuals with stress fractures and uncomplicated ankle sprains to assess their NSAID usage, revealing a significant correlation between regular NSAID use and stress fracture incidence. The study suggests that individuals at high risk of stress fractures should avoid regular NSAID use to prevent such injuries. [Extracted from the article]

Researchers at the University of Baghdad conducted a study comparing the efficacy and safety of nintedanib and pirfenidone in treating idiopathic pulmonary fibrosis (IPF) in Iraqi patients. The study found that both drugs were safe and well-tolerated, with minor side effects such as diarrhea and skin rash. Results showed that both drugs were effective in delaying the decline in lung function, with little difference in efficacy between nintedanib and pirfenidone. [Extracted from the article]

Researchers from Tehran University of Medical Sciences conducted a randomized controlled trial to evaluate the effects of adding gabapentin to a ketorolac-based regimen for acute renal colic pain. The study found that patients who received gabapentin in addition to the standard treatment showed significantly lower pain severity and reduced need for morphine compared to the control group. This suggests that gabapentin may be a beneficial adjunct to standard analgesic regimens for managing acute renal colic pain. The research highlights the potential of gabapentin to decrease opioid reliance in pain management. [Extracted from the article]

A clinical trial, NCT06640439, conducted at Huashan Hospital, focuses on LED therapy using 830 nm in mandibular third molar surgery. The trial aims to assess the efficacy of LED therapy in reducing pain, swelling, and trismus post-surgery, with a primary completion date set for February 14, 2025. The study includes detailed information on the intervention model, study arms, recruitment criteria, and administrative details, emphasizing the importance of photobiomodulation therapy and antibiotic use in the treatment protocol. [Extracted from the article]

A study conducted at the Affiliated Jiangmen Hospital of Sun Yat-sen University explored the potential of amodiaquine therapy in ameliorating stress-induced premature cellular senescence by promoting SIRT1-mediated HR repair. The research highlighted the importance of DNA repair mechanisms in combating cellular senescence and aging-related diseases. Amodiaquine was found to significantly enhance HR repair and delay the onset of stress-induced premature cellular senescence through a SIRT1-dependent pathway. This study opens up possibilities for identifying compounds that target DNA repair for therapeutic purposes in aging-related conditions. [Extracted from the article]

The patent application titled "Ketorolac Liquid Composition, Preparation Method Therefor, And Application Thereof" discusses the development of a ketorolac liquid composition that aims to address the limitations of existing ketorolac preparations. The composition includes components such as ketorolac, stabilizers, osmolarity regulators, pH regulators, and buffers, with a focus on eliminating ethanol to enhance stability, reduce irritation, and improve safety. This innovation offers a promising solution for manufacturing anti-inflammatory medications with improved efficacy and patient compliance. [Extracted from the article]

A recent study from Cairo University explores the use of Non-Steroidal Anti-Inflammatory Agents (NSAIDs) in medicine. The research highlights the importance of selective COX-2 inhibitors in managing inflammation, as they offer anti-inflammatory effects without gastrointestinal toxicity. While COX-2 selective inhibitors are safer for the gastrointestinal tract, their potential cardiovascular risks are also noted. This study sheds light on the ongoing efforts to develop new compounds with promising selective COX-2 activity. [Extracted from the article]

Researchers at the Faculty of Pharmacy have developed novel imidazole derivatives as potential analgesic and anti-inflammatory agents. The study focused on synthesizing eight new imidazole analogues, with compound 2g showing significant analgesic activity and compounds 2a and 2b exhibiting good anti-inflammatory properties. Molecular docking studies revealed the binding affinity of these compounds with the COX-2 receptor, suggesting their potential as effective pain-relieving and anti-inflammatory agents. The research highlights the promising therapeutic potential of these novel imidazole derivatives. [Extracted from the article]

Researchers at Damascus University conducted a study on the effects of troxerutin on gastric ulcers induced by ketorolac in rats. The study found that troxerutin, known for its antioxidant and anti-inflammatory properties, showed promise in preventing ketorolac-induced gastric ulcers. The research highlighted the antioxidant effect of troxerutin on gastric ulcers, suggesting its potential as a preventive measure against this condition. The study also compared the effects of troxerutin with misoprostol, a reference drug, showing improvements in ulcer indices and reduction in gastric oxidative stress with both treatments. [Extracted from the article]

The article discusses a clinical trial, NCT06633419, focusing on a study medicine called opevesostat for treating prostate cancer. The trial aims to understand how opevesostat behaves in the body over time through pharmacokinetic analysis, comparing its effects with and without carbamazepine. The study involves healthy adult male participants and is in the INTERVENTIONAL phase, with a primary completion date of November 29, 2024. The trial is not yet recruiting, with specific eligibility criteria for participants outlined in the document. [Extracted from the article]

Researchers from the Faculty of Pharmacy conducted a systematic review and meta-analysis comparing the antipyretic effects of oral dipyrone (Metamizole) and oral ibuprofen in febrile children. Despite dipyrone being banned in some high-income countries due to safety concerns, the study found no significant difference in antipyretic effectiveness between dipyrone and ibuprofen. Both medications were effective in reducing high temperatures in febrile children. The research aimed to provide valuable insights into the use of these medications in pediatric care. [Extracted from the article]

A new report from the University of Sonora in Mexico discusses the use of Agave angustifolia bagasse, a byproduct of the bacanora industry, as an adsorbent for removing ibuprofen from aqueous solutions. The researchers created bioadsorbents from the bagasse through pyrolysis and characterized them using various techniques. The study found that two of the bioadsorbents successfully removed 100% of ibuprofen from solutions. This research suggests that Agave angustifolia bagasse has potential as a biochar material for ibuprofen removal. [Extracted from the article]

A recent study conducted at Niigata University Medical and Dental Hospital in Japan has explored the use of pamidronate therapy in the treatment of generalized arterial calcification of infancy (GACI). GACI is a rare disease characterized by arterial calcification and can lead to severe hypertension and heart failure. The researchers found that pamidronate, a type of bisphosphonate, was effective in improving cardiac function in a preterm infant with GACI. They emphasize the importance of early diagnosis and appropriate treatment with bisphosphonates to improve outcomes for preterm infants with GACI. [Extracted from the article]

A report from Carthage University in Tunisia discusses research on the effects of oxide additives on the band gap and photocatalytic efficiency of TiO2. The study investigated the use of various additives, such as Y2O3, Ga2O3, and WO3, on the degradation efficiency of ketoprofen and diclofenac, two non-steroidal anti-inflammatory drugs commonly found in German rivers. The results showed that thin films containing these additives exhibited similar photocatalytic degradation efficiencies as pure TiO2, with the Y2O3/TiO2 system being the most effective in degrading diclofenac. The study also evaluated the impact of the additives on the energy band gap of TiO2. [Extracted from the article]

Researchers from the Department of Pharmaceutical Chemistry in Silvassa, India have developed a new method for quantifying beclomethasone dipropionate and fusidic acid in combination (cream) using high-performance thin-layer chromatography (HPTLC). The method was validated based on International Council for Harmonization guidelines and showed accurate and precise results. The researchers found that the method was novel, error-free, robust, and reproducible. This research provides valuable information for the development and analysis of respiratory inhalant products. [Extracted from the article]

A study conducted by researchers at Guangdong University of Technology in Guangzhou, China, has explored the use of Fe, N-doped carbon quantum dots (Fe, N-CQDs) derived from pig blood as a catalyst for the degradation of ibuprofen. Ibuprofen is a common pharmaceutical and personal care product that can be harmful to the environment and human health when it accumulates in water. The Fe, N-CQDs demonstrated strong activity in degrading ibuprofen under visible light, generating free radicals and non-radicals to effectively break down the compound. This research offers a sustainable and value-added approach to utilizing natural waste materials for environmental remediation. [Extracted from the article]

A study conducted in West Bengal, India compared the efficacy and tolerability of bepotastine besilate (1.5%) and olopatadine hydrochloride (0.1%) eye drops in patients with allergic conjunctivitis. Sixty patients were randomly assigned to receive either bepotastine or olopatadine eye drops twice daily for two weeks. Both drugs were found to effectively reduce the signs and symptoms of allergic conjunctivitis, with bepotastine being more effective in relieving itching and foreign body sensation. The study concluded that both bepotastine and olopatadine eye drops are safe and efficacious in treating allergic conjunctivitis. [Extracted from the article]

A recent study conducted by researchers at Friedrich-Alexander-University Erlangen-Nurnberg (FAU) in Germany explored the potential causal relationship between ibuprofen use and the risk of developing osteoarthritis (OA). The study utilized a two-sample Mendelian randomization analysis and found strong evidence for a causal association between ibuprofen use and an increased risk of OA. The results suggest that while ibuprofen may relieve symptoms, it may also accelerate the progression of OA. The study emphasizes the importance of cautious use of ibuprofen in clinical practice, particularly considering its potential impact on long-term joint health. [Extracted from the article]

A recent report from Northwestern University discusses the impact of anti-inflammatory and anti-fibrotic drugs on ovarian aging in mice. The study found that systemic delivery of the anti-fibrotic drug Pirfenidone reduced ovarian fibrosis and improved ovarian function in mice. The researchers suggest that modulating the ovarian environment could be a potential therapeutic approach to extend reproductive longevity. This research has been peer-reviewed and provides valuable insights into the field of women's health. [Extracted from the article]

A meta-analysis study conducted by researchers at Army Medical University in Chongqing, China compared the effectiveness and safety of olopatadine and ketotifen for allergic conjunctivitis. The study included six randomized controlled trials and found that olopatadine intervention resulted in significantly lower itching during 4-7 days and 14 days after medication compared to ketotifen intervention. However, there was no significant impact on tearing. The researchers concluded that olopatadine may provide better local treatment for allergic conjunctivitis compared to ketotifen. This research has been peer-reviewed. [Extracted from the article]

A recent study conducted at Hannover Medical School in Germany examined the use of carprofen therapy as an analgesic for mice undergoing surgical interventions. The researchers investigated the pharmacokinetics and tolerability of carprofen in male and female C57BL/6J mice, administered through subcutaneous injection and oral self-administration. The study found that high-dose carprofen was safe and had favorable pharmacokinetic profiles in both administration routes. However, it also noted potential impacts on behavioral markers used for pain assessment, such as reduced wheel running activity and slightly affected grooming behavior. Further evaluation of carprofen's efficacy and its impact on pain assessment markers is recommended. [Extracted from the article]

This article discusses a newly launched clinical trial that aims to compare the effectiveness of glucocorticoids and pain medication versus pain medication alone in treating joint pain caused by osteoarthritis. The study will assess the efficacy and safety of adding oral glucocorticoid medications to standard pain medications. Participants will be randomized into three groups and will receive different treatments for a specified period. The study will also collect data on pain scores, medication usage, and any adverse events experienced by the participants. Osteoarthritis is a prevalent condition globally, and this trial aims to provide valuable insights into its treatment. The document outlines a study that aims to examine the effectiveness and safety of adding short-term oral systemic glucocorticoids to a standardized NSAID regimen for the treatment of acute pain due to osteoarthritis (OA) in adult emergency department (ED) patients. The study will be a randomized, controlled, single-blinded trial involving patients presenting with acute, large joint monoarticular pain related to underlying OA. The primary objective is to assess the efficacy and safety of adding oral glucocorticoids to the standard treatment of acute OA pain with NSAIDs. The study will enroll a total of 192 subjects and will assess pain, adverse events, and other outcomes through follow-up phone calls and chart reviews. The researchers hypothesize that the combination of oral glucocorticoids and NSAIDs will result in improved pain control compared to NSAIDs alone and will be well tolerated. The document also provides information [Extracted from the article]