Author: "ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010)" - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010)"' showing total 207 results

Start Over Author "ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010)"

207 results on '"ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010)"'

1. Tip-Induced and Electrical Control of the Photoluminescence Yield of Monolayer WS2

Author: Ricardo Javier Peña Román, Rémi Bretel, Delphine Pommier, Luis Enrique Parra López, Etienne Lorchat, Elizabeth Boer-Duchemin, Gérald Dujardin, Andrei G. Borisov, Luiz Fernando Zagonel, Guillaume Schull, Stéphane Berciaud, Eric Le Moal, Instituto de Fisica 'Gleb Wataghin' (INSTITUTO DE FISICA 'GLEB WATAGHIN'), Universidade Estadual de Campinas = University of Campinas (UNICAMP), Institut des Sciences Moléculaires d'Orsay (ISMO), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Physics & Informatics Laboratories, NTT Research, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) projects 18/08543-7, 20/12480-0, 14/23399-9., ANR-15-CE24-0016,H2DH,Hétérostructures bi-dimendionnelles hybrides pour l'optoélectronique(2015), ANR-15-CE24-0020,INTELPLAN,Une nanosource de plasmons électrique et intégrée(2015), ANR-16-CE24-0003,M-Exc-ICO,Excitonique moléculaire pour l'optoélectronique cohérente intégrée(2016), ANR-20-CE24-0010,ATOEMS,Dispositifs opto-electro-mécaniques d'épaisseur atomique(2020), ANR-11-LABX-0058,NIE,Nanostructures en Interaction avec leur Environnement(2011), ANR-10-LABX-0035,Nano-Saclay,Paris-Saclay multidisciplinary Nano-Lab(2010), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), ANR-20-SFRI-0012,STRAT'US,Façonner les talents en formation et en recherche à l'Université de Strasbourg(2020), ANR-17-EURE-0024,QMAT,Quantum Science and Nanomaterials(2017), and European Project: 771850,APOGEE
Subjects: exciton, [PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics], Mechanical Engineering, [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], scanning tunneling microscopy, General Materials Science, Bioengineering, nano-optics, General Chemistry, 2D materials, Condensed Matter Physics
Abstract: International audience; The photoluminescence (PL) of monolayer tungsten disulfide (WS2) is locally and electrically controlled using the nonplasmonic tip and tunneling current of a scanning tunneling microscope (STM). The spatial and spectral distribution of the emitted light is determined using an optical microscope. When the STM tip is engaged, short-range PL quenching due to near-field electromagnetic effects is present, independent of the sign and value of the bias voltage applied to the tip–sample tunneling junction. In addition, a bias-voltage-dependent long-range PL quenching is measured when the sample is positively biased. We explain these observations by considering the native n-doping of monolayer WS2 and the charge carrier density gradients induced by electron tunneling in micrometer-scale areas around the tip position. The combination of wide-field PL microscopy and charge carrier injection using an STM opens up new ways to explore the interplay between excitons and charge carriers in two-dimensional semiconductors.
Published: 2022

2. Mathematical and computation framework for moving and colliding rigid bodies in a Newtonian fluid

Author: Landeghem, Céline, Berti, Luca, Chabannes, Vincent, Prud'Homme, Christophe, Chouippe, Agathe, Hoarau, Yannick, Giraldi, Laetitia, Institut de Recherche Mathématique Avancée (IRMA), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria), ITI Irmia++, and Cemosis., ANR-21-CE45-0013,NEMO,Contrôle de micro-nageurs magnétiques dans des milieux complexes et confinés(2021), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), and ANR-11-LABX-0055,IRMIA,Institut de Recherche en Mathématiques, ses Interactions et Applications(2011)
Subjects: MSC 2010 65M60, 74F10, 76M10, 70E99, rigid body motion, Fluid-structure interaction, Feel++, [MATH]Mathematics [math], collision simulation
Abstract: We studied numerically the dynamics of colliding rigid bodies in a Newtonian fluid. The finite element method is used to solve the fluid-body interaction and the fluid motion is described in the Arbitrary-Lagrangian-Eulerian framework. To model the interactions between bodies, we consider a repulsive collision-avoidance model, defined by R. Glowinski in [1]. The main emphasis in this work is the generalization of this collision model to multiple rigid bodies of arbitrary shape. Our model first uses a narrow-band fast marching method to detect the set of colliding bodies. Then, collision forces and torques are computed for these bodies via a general expression, which does not depend on their shape. Numerical experiments examining the performance of the narrow-band fast marching method and the parallel execution of the collision algorithm are discussed. We validate our model with literature results and show various applications of colliding bodies in two and three dimensions. In these applications, the bodies either move due to gravity, a flow, or can actuate themselves. Finally, we present a tool to create arbitrary shaped bodies in complex already discretized fluid domains, enabling conforming body-fluid interface and allowing to perform simulations of fluid-body interactions with collision treatment in these realistic environments. All simulations are conducted with the Feel++ open source library.
Published: 2023

3. Control over Dethreading Kinetics Allows Evaluating the Entropy Stored in an Interlocked Molecular Machine Out‐of‐Equilibrium**

Author: Simone Di Noja, Marina Garrido, Lorenzo Gualandi, Giulio Ragazzon, Institut de Science et d'ingénierie supramoléculaires (ISIS), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), and European Project: 101041933,KI-NET
Subjects: Organic Chemistry, General Chemistry, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, Catalysis
Published: 2023

4. Tumor microenvironment-derived serum markers as a new frontier of diagnostic and prognostic assessment in biliary tract cancers

Author: Romain Désert, Fabio Giannone, Catherine Schuster, Thomas F. Baumert, Institut de Recherche sur les Maladies Virales et Hépatiques (IVH), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), L'Institut hospitalo-universitaire de Strasbourg (IHU Strasbourg), Institut National de Recherche en Informatique et en Automatique (Inria)-l'Institut de Recherche contre les Cancers de l'Appareil Digestif (IRCAD)-Les Hôpitaux Universitaires de Strasbourg (HUS)-La Fédération des Crédits Mutuels Centre Est (FCMCE)-L'Association pour la Recherche contre le Cancer (ARC)-La société Karl STORZ, Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), ANR-21-RHUS-0001,DELIVER,Deliver therapeuthic innovation for advanced hepatic diseases(2021), ANR-10-LABX-0028,HepSys,Functional genomics of viral hepatitis and liver disease(2010), ANR-10-IAHU-0002,MIX-Surg,Institut de Chirurgie Mini-Invasive guidée par l'Image(2010), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), and ANR-17-EURE-0023,IMCBio,Integrative Molecular and Cellular Biology(2017)
Subjects: Cancer Research, Oncology, [SDV.CAN]Life Sciences [q-bio]/Cancer, pathology, Sciences du Vivant [q-bio]/Médecine humaine et pathologie, Sciences du Vivant [q-bio]/Cancer
Abstract: editorial research support, n.i.h., extramural research support, non-u.s. gov't 2023 Mar 01 2022 12 01 imported
Published: 2023

5. Inhibiting cell-to-cell transmission to reach HDV cure: The importance of IFN-α

Author: Julie Lucifora, Eloi R. Verrier, Thomas F. Baumert, Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche sur les Maladies Virales et Hépatiques (IVH), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), L'Institut hospitalo-universitaire de Strasbourg (IHU Strasbourg), Institut National de Recherche en Informatique et en Automatique (Inria)-l'Institut de Recherche contre les Cancers de l'Appareil Digestif (IRCAD)-Les Hôpitaux Universitaires de Strasbourg (HUS)-La Fédération des Crédits Mutuels Centre Est (FCMCE)-L'Association pour la Recherche contre le Cancer (ARC)-La société Karl STORZ, Les Hôpitaux Universitaires de Strasbourg (HUS), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), ANR-20-SFRI-0012,STRAT'US,Façonner les talents en formation et en recherche à l'Université de Strasbourg(2020), ANR-17-EURE-0023,IMCBio,Integrative Molecular and Cellular Biology(2017), ANR-21-CE15-0035,DELTArget,Caractérisation de facteur cellulaires impliqués dans l'infection par le virus de l'hépatite D pour la caractérisation de nouvelles cibles antivirales(2021), European Project: 101021417,FIBCAN, and European Project: 671231,H2020,ERC-2014-ADG,HEPCIR(2016)
Subjects: Hepatology, Interferon-alpha, Hepatitis Delta Virus, Sciences du Vivant [q-bio]/Médecine humaine et pathologie, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: editorial research support, non-u.s. gov't 2022 Oct 2022 08 08 imported
Published: 2022

6. Two-Dimensional Violet Phosphorus: A p-Type Semiconductor for (Opto)electronics

Author: Ricciardulli, Antonio Gaetano, Wang, Ye, Yang, Sheng, Samorì, Paolo, Institut de Science et d'ingénierie supramoléculaires (ISIS), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Technische Universität Dresden = Dresden University of Technology (TU Dresden), ANR-10-LABX-0026,CSC,Center of Chemistry of Complex System(2010), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), European Project: 833707,SUPRA2DMAT, and European Project: 881603,H2020,H2020-SGA-FET-GRAPHENE-2019, GrapheneCore3(2020)
Subjects: Colloid and Surface Chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, General Chemistry, Biochemistry, Catalysis
Abstract: International audience; The synthesis of novel two-dimensional (2D) materials displaying an unprecedented composition and structure via the exfoliation of layered systems provides access to uncharted properties. For application in optoelectronics, a vast majority of exfoliated 2D semiconductors possess n-type or more seldom ambipolar characteristics. The shortage of p-type 2D semiconductors enormously hinders the extensive engineering of 2D devices for complementary metal oxide semiconductors (CMOSs) and beyond CMOS applications. However, despite the recent progress in the development of 2D materials endowed with p-type behaviors by direct synthesis or p-doping strategies, finding new structures is still of primary importance. Here, we report the sonication-assisted liquid-phase exfoliation of violet phosphorus (VP) crystals into few-layer-thick flakes and the first exploration of their electrical and optical properties. Field-effect transistors based on exfoliated VP thin films exhibit a p-type transport feature with an Ion/Ioff ratio of 10^4 and a hole mobility of 2.25 cm2 V–1 s–1 at room temperature. In addition, the VP film-based photodetectors display a photoresponsivity (R) of 10 mA W–1 and a response time down to 0.16 s. Finally, VP embedded into CMOS inverter arrays displays a voltage gain of ∼17. This scalable production method and high quality of the exfoliated material combined with the excellent optoelectronic performances make VP an enticing and versatile p-type candidate for next-generation more-than-Moore (opto)electronics.
Published: 2022

7. Manipulating the Self-Assembly of Phenyleneethynylenes under Vibrational Strong Coupling

Author: Sandeep, Kulangara, Joseph, Kripa, Gautier, Jérôme, Nagarajan, Kalaivanan, Sujith, Meleppatt, Thomas, K. George, Ebbesen, Thomas W., Institut de Science et d'ingénierie supramoléculaires (ISIS), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Indian Institute of Science Education and Research Thiruvananthapuram (IISER TVM), ANR-10-EQPX-0052,UNION,Optique Ultrarapide, Nanophotonique et Plasmonique(2010), ANR-10-LABX-0026,CSC,Center of Chemistry of Complex System(2010), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), European Project: 788482,MOLUSC, and European Project: 811284,UHMob
Subjects: [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, General Materials Science, Physical and Theoretical Chemistry
Abstract: The chemical and physical properties of molecules and materials are known to be modified significantly under vibrational strong coupling (VSC). To gain insight into the effects of VSC on π-π interactions involved in molecular self-assembly, themselves sensitive to vacuum electromagnetic field fluctuations, the aggregation of two structural isomers (linear and V-shaped) of phenyleneethynylene under cooperative coupling was investigated. By coupling the aromatic C═C stretching band, the assembly of one of the molecules results in the formation of spheres as opposed to flakes under normal conditions. As a consequence, the electronic absorption and emission spectra of the self-assembled structures are also modified significantly. The VSC-induced changes depend not only on the type of vibration that is coupled but also on the symmetry of the phenyleneethynylene isomer. These results confirm that VSC can be used to drive molecular assemblies to new structural minima and thereby provide a new tool for supramolecular chemistry.
Published: 2022

8. 3D multiscale analysis of the hierarchical porosity in Coscinodiscus sp. diatoms using a combination of tomographic techniques

Author: Othmane Darouich, Walid Baaziz, Dris Ihiawakrim, Charles Hirlimann, Danièle Spehner, Patrick Schultz, Hedwige Poncet, Virgile Rouchon, Sana Labidi, Corinne Petit, Pierre Levitz, Ovidiu Ersen, Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), IFP Energies nouvelles (IFPEN), Institut de chimie et procédés pour l'énergie, l'environnement et la santé (ICPEES), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), PHysicochimie des Electrolytes et Nanosystèmes InterfaciauX (PHENIX), Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), APC 1902 €, ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), ANR-20-SFRI-0002,GP-DS,Graduate Programs pour les études doctorales(2020), ANR-17-EURE-0024,QMAT,Quantum Science and Nanomaterials(2017), Belli, Catherine, Initiative d'excellence - Par-delà les frontières, l'Université de Strasbourg - - UNISTRA2010 - ANR-10-IDEX-0002 - IDEX - VALID, Graduate Programs pour les études doctorales - - GP-DS2020 - ANR-20-SFRI-0002 - SFRI - VALID, and Quantum Science and Nanomaterials - - QMAT2017 - ANR-17-EURE-0024 - EURE - VALID
Subjects: [SDV] Life Sciences [q-bio], [SDE] Environmental Sciences, [SDV]Life Sciences [q-bio], [SDE]Environmental Sciences, [CHIM] Chemical Sciences, General Engineering, [CHIM]Chemical Sciences, General Materials Science, Bioengineering, General Chemistry, Atomic and Molecular Physics, and Optics
Abstract: International audience; A full 3D analysis of the hierarchical porosity in Coscinodiscus sp. diatom structures was carried out by using a multiscale approach that combines three advanced volumetric imaging techniques with resolutions and fields of view covering all the porous characteristics of such complex architectures: electron tomography, "slice and view" approach that uses a dual-beam microscope (FIB-SEM), and array tomography consisting of serial imaging of ultrathin specimen sections. This multiscale approach allowed the whole porosity network to be quantified and provided an unprecedented structural insight into these natural nanostructured materials with internal organization ranging from micrometer to nanometer. The analysed species is made of several nested layers with different pore sizes, shapes and connectivities and characterized by the presence of interconnected pores structured in various ways. The first evidence of the presence of a nanometric porosity made of ellipsoidal pores in the siliceous diatom frustules is also provided.
Published: 2022

9. Humidity Sensing with Supramolecular Nanostructures

Author: Verónica Montes García, Paolo Samorì, Institut de Science et d'ingénierie supramoléculaires (ISIS), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), univOAK, Archive ouverte, ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), and European Project: 833707,SUPRA2DMAT
Subjects: water receptors, Mechanics of Materials, [CHIM.OTHE] Chemical Sciences/Other, Mechanical Engineering, sensing mechanism, humidity sensors, General Materials Science, supramolecular nanostructures, [CHIM.OTHE]Chemical Sciences/Other
Abstract: Precise monitoring of the humidity level is important for the living comfort and for many applications in various industrial sectors. Humidity sensors have thus become one among the most extensively studied and used chemical sensors by targeting a maximal device performance through the optimization of the components and working mechanism. Among different moisture-sensitive systems, supramolecular nanostructures are ideal active materials for the next generation of highly efficient humidity sensors. Their noncovalent nature guarantees fast response, high reversibility, and fast recovery time in the sensing event. Herein, the most enlightening recent strategies on the use of supramolecular nanostructures for humidity sensing are showcased. The key performance indicators in humidity sensing, including operation range, sensitivity, selectivity, response, and recovery speed are discussed as milestones for true practical applications. Some of the most remarkable examples of supramolecular-based humidity sensors are presented, by describing the finest sensing materials, the operating principles, and sensing mechanisms, the latter being based on the structural or charge-transport changes triggered by the interaction of the supramolecular nanostructures with the ambient humidity. Finally, the future directions, challenges, and opportunities for the development of humidity sensors with performance beyond the state of the art are discussed.
Published: 2023

10. Covalently functionalized MXenes for highly sensitive humidity sensors

Author: Iwona Janica, Verónica Montes‐García, Francesca Urban, Payam Hashemi, Ali Shaygan Nia, Xinliang Feng, Paolo Samorì, Artur Ciesielski, Institut de Science et d'ingénierie supramoléculaires (ISIS), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), European Project: 833707,SUPRA2DMAT, and European Project: 881603,H2020,H2020-SGA-FET-GRAPHENE-2019, GrapheneCore3(2020)
Subjects: General Materials Science, [CHIM.MATE]Chemical Sciences/Material chemistry, General Chemistry
Abstract: Transition metal carbides and nitrides (MXenes) are an emerging class of 2D materials, which are attracting ever-growing attention due to their remarkable physicochemical properties. The presence of various surface functional groups on MXenes’ surface, e.g., –F, –O, –OH, –Cl, opens the possibility to tune their properties through chemical functionalization approaches. However, only a few methods have been explored for the covalent functionalization of MXenes and include diazonium salt grafting and silylation reactions. Here, an unprecedented two-step functionalization of Ti3C2Tx MXenes is reported, where (3-aminopropyl)triethoxysilane is covalently tethered to Ti3C2Tx and serves as an anchoring unit for subsequent attachment of various organic bromides via the formation of C–N bonds. Thin films of Ti3C2Tx functionalized with linear chains possessing increased hydrophilicity are employed for the fabrication of chemiresistive humidity sensors. The devices exhibit a broad operation range (0–100% relative humidity), high sensitivity (0.777 or 3.035), a fast response/recovery time (0.24/0.40 s ΔH−1, respectively), and high selectivity to water in the presence of saturated vapors of organic compounds. Importantly, our Ti3C2Tx-based sensors display the largest operating range and a sensitivity beyond the state of the art of MXenes-based humidity sensors. Such outstanding performance makes the sensors suitable for real-time monitoring applications.
Published: 2023

11. Non-invasive digital etching of van der Waals semiconductors

Author: Jian Zhou, Chunchen Zhang, Li Shi, Xiaoqing Chen, Tae Soo Kim, Minseung Gyeon, Jian Chen, Jinlan Wang, Linwei Yu, Xinran Wang, Kibum Kang, Emanuele Orgiu, Paolo Samorì, Kenji Watanabe, Takashi Taniguchi, Kazuhito Tsukagoshi, Peng Wang, Yi Shi, Songlin Li, univOAK, Archive ouverte, Nanjing University (NJU), Nanjing Southeast University (SEU), Korea Advanced Institute of Science and Technology (KAIST), Centre Énergie Matériaux Télécommunications, Institut National de la Recherche Scientifique [Quebec], Institut de Science et d'ingénierie supramoléculaires (ISIS), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), National Institute for Materials Science (NIMS), University of Warwick [Coventry], ANR-10-LABX-0026,CSC,Center of Chemistry of Complex System(2010), ANR-11-LABX-0058,NIE,Nanostructures en Interaction avec leur Environnement(2011), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), European Project: 833707,SUPRA2DMAT, and European Project: 881603,H2020,H2020-SGA-FET-GRAPHENE-2019, GrapheneCore3(2020)
Subjects: [CHIM.MATE] Chemical Sciences/Material chemistry, Condensed Matter - Materials Science, Multidisciplinary, Condensed Matter - Mesoscale and Nanoscale Physics, TK, Mesoscale and Nanoscale Physics (cond-mat.mes-hall), Materials Science (cond-mat.mtrl-sci), FOS: Physical sciences, General Physics and Astronomy, [CHIM.MATE]Chemical Sciences/Material chemistry, General Chemistry, General Biochemistry, Genetics and Molecular Biology
Abstract: The capability to finely tailor material thickness with simultaneous atomic precision and non-invasivity would be useful for constructing quantum platforms and post-Moore microelectronics. However, it remains challenging to attain synchronized controls over tailoring selectivity and precision. Here we report a protocol that allows for non-invasive and atomically digital etching of van der Waals transition-metal dichalcogenides through selective alloying via low-temperature thermal diffusion and subsequent wet etching. The mechanism of selective alloying between sacrifice metal atoms and defective or pristine dichalcogenides is analyzed with high-resolution scanning transmission electron microscopy. Also, the non-invasive nature and atomic level precision of our etching technique are corroborated by consistent spectral, crystallographic and electrical characterization measurements. The low-temperature charge mobility of as-etched MoS$_2$ reaches up to $1200\,$cm$^{2}\cdot$V$^{-1}\cdot$s$^{-1}$, comparable to that of exfoliated pristine counterparts. The entire protocol represents a highly precise and non-invasive tailoring route for material manipulation., 46 pages, 4 figures, with SI
Published: 2023

12. Kinetic Barrier Diagrams to Visualize and Engineer Molecular Nonequilibrium Systems

Author: GIULIO RAGAZZON, Emanuele Penocchio, Institut de Science et d'ingénierie supramoléculaires (ISIS), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université Louis Pasteur - Strasbourg I-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), European Project: 101041933,KI-NET, and European Project: 681456,H2020,ERC-2015-CoG,NanoThermo(2016)
Subjects: Biomaterials, [PHYS.PHYS]Physics [physics]/Physics [physics], General Materials Science, General Chemistry, Biotechnology
Abstract: International audience; Molecular nonequilibrium systems hold great promises for the nanotechnology of the future. Yet, their development is slowed by the absence of an informative representation. Indeed, while potential energy surfaces comprise in principle all the information, they hide the dynamic interplay of multiple reaction pathways underlying nonequilibrium systems, i.e., the degree of kinetic asymmetry. To offer an insightful visual representation of kinetic asymmetry, we extended an approach pertaining to catalytic networks, the energy span model, by focusing on system dynamics – rather than thermodynamics. Our approach encompasses both chemically and photochemically driven systems, ranging from unimolecular motors to simple self-assembly schemes. The obtained diagrams give immediate access to information needed to guide experiments, such as states’ population, rate of machine operation, maximum work output, and effects of design changes. The proposed kinetic barrier diagrams offer a unifying graphical tool for disparate nonequilibrium phenomena.
Published: 2023

13. Mechanisms of Radical Formation on Chemically Modified Graphene Oxide under Near Infrared Irradiation

Author: Lucas Jacquemin, Zhengmei Song, Nolwenn Le Breton, Yuta Nishina, Sylvie Choua, Giacomo Reina, Alberto Bianco, Immunologie, Immunopathologie et Chimie Thérapeutique (I2CT), Institut de biologie moléculaire et cellulaire (IBMC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie de Strasbourg, Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), and European Project: 881603,H2020,H2020-SGA-FET-GRAPHENE-2019, GrapheneCore3(2020)
Subjects: Biomaterials, General Materials Science, General Chemistry, Chimie/Chimie thérapeutique, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, Biotechnology
Abstract: International audience; In this work, the mechanisms of radical generation on different functionalized graphene oxide (GO) conjugates under near-infrared (NIR) light irradiation are investigated. The GO conjugates are designed to understand how chemical functionalization can influence the generation of radicals. Both pristine and functionalized GO are irradiated by a NIR laser, and the production of different reactive oxygen species (ROS) is investigated using fluorimetry and electron paramagnetic resonance to describe the type of radicals present on the surface of GO. The mechanism of ROS formation involves a charge transfer from the material to the oxygen present in the media, via the production of superoxide and singlet oxygen. Cytotoxicity and effects of ROS generation are then evaluated using breast cancer cells, evidencing a concentration dependent cell death associated to the heat and ROS. The study provides new hints to understand the photogeneration of radicals on the surface of GO upon near infrared irradiation, as well as, to assess the impact on these radicals in the context of a combined drug delivery system and phototherapeutic approach. These discoveries open the way for a better control of phototherapy-based treatments employing graphene-based materials.
Published: 2023

14. Tight Junction Protein Signaling and Cancer Biology

Author: Zeina Nehme, Natascha Roehlen, Punita Dhawan, Thomas F. Baumert, Institut de Recherche sur les Maladies Virales et Hépatiques (IVH), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Medicine II, University Hospital Freiburg, Buffet Cancer Center [Omaha, NE, USA], University of Nebraska Medical Center, University of Nebraska System-University of Nebraska System, VA Nebraska-Western Iowa Health Care System [Omaha, NE, USA], L'Institut hospitalo-universitaire de Strasbourg (IHU Strasbourg), Institut National de Recherche en Informatique et en Automatique (Inria)-l'Institut de Recherche contre les Cancers de l'Appareil Digestif (IRCAD)-Les Hôpitaux Universitaires de Strasbourg (HUS)-La Fédération des Crédits Mutuels Centre Est (FCMCE)-L'Association pour la Recherche contre le Cancer (ARC)-La société Karl STORZ, Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), ANR-21-RHUS-0001,DELIVER,Deliver therapeuthic innovation for advanced hepatic diseases(2021), ANR-10-LABX-0028,HepSys,Functional genomics of viral hepatitis and liver disease(2010), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), ANR-17-EURE-0023,IMCBio,Integrative Molecular and Cellular Biology(2017), ANR-20-SFRI-0012,STRAT'US,Façonner les talents en formation et en recherche à l'Université de Strasbourg(2020), European Project: 671231,H2020,ERC-2014-ADG,HEPCIR(2016), European Project: 101021417,FIBCAN, European Project: 755460,PRELICAN, and European Project: 862551,HEPCAN
Subjects: tight junctions carcinogenesis signaling pathways therapeutic targets, tight junctions, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, General Medicine, Sciences du Vivant [q-bio]/Médecine humaine et pathologie, therapeutic targets, metabolism, carcinogenesis, signaling pathways
Abstract: Tight junctions (TJs) are intercellular protein complexes that preserve tissue homeostasis and integrity through the control of paracellular permeability and cell polarity. Recent findings have revealed the functional role of TJ proteins outside TJs and beyond their classical cellular functions as selective gatekeepers. This is illustrated by the dysregulation in TJ protein expression levels in response to external and intracellular stimuli, notably during tumorigenesis. A large body of knowledge has uncovered the well-established functional role of TJ proteins in cancer pathogenesis. Mechanistically, TJ proteins act as bidirectional signaling hubs that connect the extracellular compartment to the intracellular compartment. By modulating key signaling pathways, TJ proteins are crucial players in the regulation of cell proliferation, migration, and differentiation, all of which being essential cancer hallmarks crucial for tumor growth and metastasis. TJ proteins also promote the acquisition of stem cell phenotypes in cancer cells. These findings highlight their contribution to carcinogenesis and therapeutic resistance. Moreover, recent preclinical and clinical studies have used TJ proteins as therapeutic targets or prognostic markers. This review summarizes the functional role of TJ proteins in cancer biology and their impact for novel strategies to prevent and treat cancer. journal article review research support, non-u.s. gov't research support, n.i.h., extramural research support, u.s. gov't, non-p.h.s. 2023 Jan 06 2023 01 06 imported
Published: 2023

15. Scavenger receptor class B type I genetic variants associated with disease severity in chronic hepatitis C virus infection

Author: Victoria L. Arandhara, Charles Patrick McClure, Alexander W. Tarr, Sally Chappell, Kevin Morgan, Thomas F. Baumert, William L. Irving, Jonathan K. Ball, Institut de Recherche sur les Maladies Virales et Hépatiques (IVH), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), L'Institut hospitalo-universitaire de Strasbourg (IHU Strasbourg), Institut National de Recherche en Informatique et en Automatique (Inria)-l'Institut de Recherche contre les Cancers de l'Appareil Digestif (IRCAD)-Les Hôpitaux Universitaires de Strasbourg (HUS)-La Fédération des Crédits Mutuels Centre Est (FCMCE)-L'Association pour la Recherche contre le Cancer (ARC)-La société Karl STORZ, ANR-20-SFRI-0012,STRAT'US,Façonner les talents en formation et en recherche à l'Université de Strasbourg(2020), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), and European Project: 101021417,FIBCAN
Subjects: Infectious Diseases, complications, genetics, Virology, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, Sciences du Vivant [q-bio]/Médecine humaine et pathologie, metabolism
Abstract: Analysis of host genetic polymorphisms is an increasingly important tool for understanding and predicting pathogenesis and treatment response of viral diseases. The gene locus of scavenger receptor class B type I (SR-BI), encoding a cell entry factor and receptor for hepatitis C virus (HCV), contains several genetic polymorphisms. We applied a probe extension assay to determine the frequency of six single nucleotide polymorphisms (SNPs) within the SR-BI gene locus in 374 individuals with history of HCV infection. In addition, SR-BI messenger RNA (mRNA) levels were analyzed in liver biopsy specimens of chronically infected HCV subjects. The rs5888 variant allele T was present at a higher frequency in subjects with advanced fibrosis (χ journal article research support, non-u.s. gov't 2023 Jan imported
Published: 2023

16. Strong Coupling of Chiral Frenkel Exciton for Intense, Bisignate Circularly Polarized Luminescence

Author: Minghao Li, Shahana Nizar, Sudipta Saha, Anoop Thomas, Stefano Azzini, Thomas W. Ebbesen, Cyriaque Genet, univOAK, Archive ouverte, Initiative d'excellence - Par-delà les frontières, l'Université de Strasbourg - - UNISTRA2010 - ANR-10-IDEX-0002 - IDEX - VALID, Façonner les talents en formation et en recherche à l'Université de Strasbourg - - STRAT'US2020 - ANR-20-SFRI-0012 - SFRI - VALID, Institut de Science et d'ingénierie supramoléculaires (ISIS), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Indian Institute of Science, University of Trento [Trento], ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), and ANR-20-SFRI-0012,STRAT'US,Façonner les talents en formation et en recherche à l'Université de Strasbourg(2020)
Subjects: Self-Assembly, [CHIM.INOR] Chemical Sciences/Inorganic chemistry, Exciton Coupling, Circularly Polarized Emission, Mueller Polarimetry, General Medicine, General Chemistry, Chirality, [CHIM.INOR]Chemical Sciences/Inorganic chemistry, Catalysis
Abstract: We show that chiral Frenkel excitons yield intense circularly polarized luminescence with an intrinsic dissymmetry factor in emission glum as high as 0.08. This outstanding value is measured through thin films of cyanine J-aggregates that form twisted bundles. Our measurements, obtained by a Mueller polarization analysis, are artifact-free and reveal a quasi-perfect correlation between the dissymmetry factors in absorption, gabs , and in emission glum . We interpret the bisignate dissymmetry factors as the signature of a strong coupling between chiral Frenkel excitons longitudinally excited along the bundles. We further resolve by polarimetry analysis the split in energy between the excited states with a Davydov splitting as small as 28 meV. We finally show the anti-Kasha nature of the chiral emission bands with opposite optical chirality. These mirror-imaged emissive chiroptical features emerge from the structural rigidity of the bundles that preserves the ground- and excited-state chirality.
Published: 2023

17. Supramolecular Engineering of Cathode Materials for Aqueous Zinc-ion Energy Storage Devices: Novel Benzothiadiazole Functionalized Two-Dimensional Olefin-Linked COFs

Author: Haijun Peng, Senhe Huang, Verónica Montes‐García, Dawid Pakulski, Haipeng Guo, Fanny Richard, Xiaodong Zhuang, Paolo Samorì, Artur Ciesielski, Institut de Science et d'ingénierie supramoléculaires (ISIS), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Shanghai Jiao Tong University [Shanghai], Adam Mickiewicz University in Poznań (UAM), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), and European Project: 813036,ULTIMATE
Subjects: General Medicine, General Chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, Catalysis
Abstract: International audience; Two-dimensional covalent organic frameworks (COFs) have emerged as promising materials for energy storage applications exhibiting enhanced electrochemical performance. While most of the reported organic cathode materials for zinc-ion batteries use carbonyl groups as electrochemically-active sites, their high hydrophilicity in aqueous electrolytes represents a critical drawback. Herein, we report a novel and structurally robust olefin-linked COF-TMT-BT synthesized via the aldol condensation between 2,4,6-trimethyl-1,3,5-triazine (TMT) and 4,4′-(benzothiadiazole-4,7-diyl)dibenzaldehyde (BT), where benzothiadiazole units are explored as novel electrochemically-active groups. Our COF-TMT-BT exhibits an outstanding Zn2+ storage capability, delivering a state-of-the-art capacity of 283.5 mAh g−1 at 0.1 A g−1. Computational and experimental analyses reveal that the charge-storage mechanism in COF-TMT-BT electrodes is based on the supramolecularly engineered and reversible Zn2+ coordination by the benzothiadiazole units.
Published: 2023

18. Autonomous Non‐Equilibrium Self‐Assembly and Molecular Movements Powered by Electrical Energy**

Author: Giulio Ragazzon, Marco Malferrari, Arturo Arduini, Andrea Secchi, Stefania Rapino, Serena Silvi, Alberto Credi, Institut de Science et d'ingénierie supramoléculaires (ISIS), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), University of Bologna/Università di Bologna, Università degli studi di Parma = University of Parma (UNIPR), Consiglio Nazionale delle Ricerche [Bologna] (CNR), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), European Project: 692981,LEAPS, and univOAK, Archive ouverte
Subjects: Molecular Machines, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Calixarene, Electrochemistry, General Chemistry, General Medicine, [CHIM.ORGA] Chemical Sciences/Organic chemistry, Non-Equilibrium Processes, SECM, Catalysis
Abstract: The ability to exploit energy autonomously is one of the hallmarks of Life. Mastering such processes in artificial nanosystems can open unforeseen technological opportunities. In the last decades, light- and chemically-driven autonomous systems have been developed in relation to conformational motion and self-assembly, mostly in relation to molecular motors. On the contrary, despite electrical energy is an attractive energy source to power nanosystems, its autonomous exploitation remains essentially unexplored. Herein we demonstrate the autonomous exploitation of electrical energy by a self-assembling system. Threading and dethreading motions of a pseudorotaxane take place autonomously in solution, between the electrodes of a scanning electrochemical microscope. This innovative actuation mode allows operating a molecular machine with an energy efficiency of 9%, unprecedented in autonomous systems. The strategy is general and can be applied to any redox-driven system. Ultimately, our study brings molecular nanoscience one step closer to everyday technology.
Published: 2022

19. Polyglutamine-expanded ATXN7 alters a specific epigenetic signature underlying photoreceptor identity gene expression in SCA7 mouse retinopathy

Author: Anna Niewiadomska-Cimicka, Antoine Hache, Stéphanie Le Gras, Céline Keime, Tao Ye, Aurelie Eisenmann, Imen Harichane, Michel J. Roux, Nadia Messaddeq, Emmanuelle Clérin, Thierry Léveillard, Yvon Trottier, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de la Vision, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), ANR-18-CE12-0026,SAGA-Retina,Rôle du complexe co-activateur SAGA dans la transcription au cours de la différenciation cellulaire chez les mammifères(2018), ANR-15-JPWG-0008,ModelPolyQ,Advanced models of polyglutamine disorders -HD, SCA2, SCA3, SCA7-(2015), ANR-10-LABX-0030,INRT,Integrative Biology : Nuclear dynamics- Regenerative medicine - Translational medicine(2010), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), and European Project: 643417,H2020,H2020-HCO-2014,JPco-fuND(2015)
Subjects: [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Endocrinology, Diabetes and Metabolism, Biochemistry (medical), Clinical Biochemistry, Pharmacology (medical), Cell Biology, General Medicine, [SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs, Molecular Biology
Abstract: Background Spinocerebellar ataxia type 7 (SCA7) is a neurodegenerative disorder that primarily affects the cerebellum and retina. SCA7 is caused by a polyglutamine expansion in the ATXN7 protein, a subunit of the transcriptional coactivator SAGA that acetylates histone H3 to deposit narrow H3K9ac mark at DNA regulatory elements of active genes. Defective histone acetylation has been presented as a possible cause for gene deregulation in SCA7 mouse models. However, the topography of acetylation defects at the whole genome level and its relationship to changes in gene expression remain to be determined. Methods We performed deep RNA-sequencing and chromatin immunoprecipitation coupled to high-throughput sequencing to examine the genome-wide correlation between gene deregulation and alteration of the active transcription marks, e.g. SAGA-related H3K9ac, CBP-related H3K27ac and RNA polymerase II (RNAPII), in a SCA7 mouse retinopathy model. Results Our analyses revealed that active transcription marks are reduced at most gene promoters in SCA7 retina, while a limited number of genes show changes in expression. We found that SCA7 retinopathy is caused by preferential downregulation of hundreds of highly expressed genes that define morphological and physiological identities of mature photoreceptors. We further uncovered that these photoreceptor genes harbor unusually broad H3K9ac profiles spanning the entire gene bodies and have a low RNAPII pausing. This broad H3K9ac signature co-occurs with other features that delineate superenhancers, including broad H3K27ac, binding sites for photoreceptor specific transcription factors and expression of enhancer-related non-coding RNAs (eRNAs). In SCA7 retina, downregulated photoreceptor genes show decreased H3K9 and H3K27 acetylation and eRNA expression as well as increased RNAPII pausing, suggesting that superenhancer-related features are altered. Conclusions Our study thus provides evidence that distinctive epigenetic configurations underlying high expression of cell-type specific genes are preferentially impaired in SCA7, resulting in a defect in the maintenance of identity features of mature photoreceptors. Our results also suggest that continuous SAGA-driven acetylation plays a role in preserving post-mitotic neuronal identity.
Published: 2022

20. Automatic Ferroelectric Domain Pattern Recognition Based on the Analysis of Localized Nonlinear Optical Responses Assisted by Machine Learning

Author: Boris Croes, Iaroslav Gaponenko, Cédric Voulot, Olivier Grégut, Kokou D. Dorkenoo, Fabien Cheynis, Stefano Curiotto, Pierre Müller, Frédéric Leroy, Kumara Cordero‐Edwards, Patrycja Paruch, Salia Cherifi‐Hertel, Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Department of Quantum Matter Physics [Geneva] (DQMP), Université de Genève = University of Geneva (UNIGE), Centre Interdisciplinaire de Nanoscience de Marseille (CINaM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), ANR-18-CE92-0052,TOPELEC,Topologie de Parois Ferroélectriques Conductrices(2018), ANR-22-CE08-0023,FETh,Contrôle ferroélectrique de la conduction électrique et thermique à l'échelle nanométrique dans GeTe(2022), ANR-17-EURE-0024,QMAT,Quantum Science and Nanomaterials(2017), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), ANR-20-SFRI-0012,STRAT'US,Façonner les talents en formation et en recherche à l'Université de Strasbourg(2020), CHERIFI-HERTEL, Salia, APPEL À PROJETS GÉNÉRIQUE 2018 - Topologie de Parois Ferroélectriques Conductrices - - TOPELEC2018 - ANR-18-CE92-0052 - AAPG2018 - VALID, Contrôle ferroélectrique de la conduction électrique et thermique à l'échelle nanométrique dans GeTe - - FETh2022 - ANR-22-CE08-0023 - AAPG2022 - VALID, Quantum Science and Nanomaterials - - QMAT2017 - ANR-17-EURE-0024 - EURE - VALID, Initiative d'excellence - Par-delà les frontières, l'Université de Strasbourg - - UNISTRA2010 - ANR-10-IDEX-0002 - IDEX - VALID, and Façonner les talents en formation et en recherche à l'Université de Strasbourg - - STRAT'US2020 - ANR-20-SFRI-0012 - SFRI - VALID
Subjects: MESH: Non-Negative Matrix Factorization, MESH: Ferroelectrics, MESH: Machine Learning, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], MESH: Second-Hermonic Generation, MESH: Clustering Methods, [PHYS.COND.CM-MS] Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], MESH: Domains
Abstract: International audience; Second-harmonic generation (SHG) is a nonlinear optical method allowing the study of the local structure, symmetry, and ferroic order in noncentrosymmetric materials such as ferroelectrics. The combination of SHG microscopy with local polarization analysis is particularly efficient for deriving the local polarization orientation. This, however, entails the use of tedious and time-consuming modeling methods of nonlinear optical emission. Moreover, extracting the complex domain structures often observed in thin films requires a pixel-by-pixel analysis and the fitting of numerous polar plots to ascribe a polarization angle to each pixel. Here, the domain structure of GeTe films is studied using SHG polarimetry assisted by machine learning. The method is applied to two film thicknesses: A thick film containing large domains visible in SHG images, and a thin film in which the domains' size is below the SHG resolution limit. Machine learning-assisted methods show that both samples exhibit four domain variants of the same type. This result is confirmed in the case of the thick film, both by the manual pixel-by-pixel analysis and by using piezoresponse force microscopy. The proposed approach foreshows new prospects for optical studies by enabling enhanced sensitivity and high throughput analysis.
Published: 2022

21. Promoting socially desirable behaviors through persuasion and commitment: Experimental evidence

Author: Cécile Bazart, Mathieu Lefebvre, Julie Rosaz, Centre d'Economie de l'Environnement - Montpellier (CEE-M), Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Montpellier (UM), Aix-Marseille Sciences Economiques (AMSE), École des hautes études en sciences sociales (EHESS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Burgundy School of Business (BSB) - Ecole Supérieure de Commerce de Dijon Bourgogne (ESC) (BSB), Centre de Recherche sur l'ENtreprise [Dijon] (CEREN), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), ANR-10-LABX-0079,AMSE,Aix-Marseille School of Economices(2010), and ANR-11-IDEX-0001,Amidex,INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE(2011)
Subjects: Economics and Econometrics, Commitment, Communication, Persuasion, Voluntary contribution mechanism, JEL: H - Public Economics/H.H4 - Publicly Provided Goods/H.H4.H41 - Public Goods, General Social Sciences, JEL: C - Mathematical and Quantitative Methods/C.C9 - Design of Experiments/C.C9.C91 - Laboratory, Individual Behavior, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, JEL: D - Microeconomics/D.D9 - Intertemporal Choice/D.D9.D91 - Intertemporal Household Choice • Life Cycle Models and Saving, Applied Psychology
Abstract: International audience; Through a series of experiments, this paper tests the relative efficiency of persuasion and commitment schemes to increase and sustain contribution levels in a Voluntary Contribution Game. The design allows us to compare a baseline consisting of a repeated public good game to four treatments of the same game in which we successively introduce a persuasion message, commitment devices, and communication between subjects. Our results suggest that these non-monetary procedures significantly increase cooperation and reduce the decay of contributions across periods.
Published: 2022

22. Unveiling Unconventional Ferroelectric Switching in Multiferroic Ga0.6 Fe1.4O3 Thin Films Through Multiscale Electron Microscopy Investigations

Author: Anna Demchenko, Suvidyakumar Homkar, Corinne Bouillet, Christophe Lefèvre, François Roulland, Daniele Preziosi, Gilles Versini, Cédric Leuvrey, Philippe Boullay, Xavier Devaux, Nathalie Viart, Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de cristallographie et sciences des matériaux (CRISMAT), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche sur les Matériaux Avancés (IRMA), Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Rouen Normandie (UNIROUEN), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Institut Jean Lamour (IJL), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), ANR-18-CE24-0008,MISSION,Oxydes magnétoélectriques pour la SpinOrbitronique(2018), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), ANR-20-SFRI-0012,STRAT'US,Façonner les talents en formation et en recherche à l'Université de Strasbourg(2020), ANR-17-EURE-0024,QMAT,Quantum Science and Nanomaterials(2017), ANR-11-LABX-0058,NIE,Nanostructures en Interaction avec leur Environnement(2011), Viart, Nathalie, APPEL À PROJETS GÉNÉRIQUE 2018 - Oxydes magnétoélectriques pour la SpinOrbitronique - - MISSION2018 - ANR-18-CE24-0008 - AAPG2018 - VALID, Initiative d'excellence - Par-delà les frontières, l'Université de Strasbourg - - UNISTRA2010 - ANR-10-IDEX-0002 - IDEX - VALID, Façonner les talents en formation et en recherche à l'Université de Strasbourg - - STRAT'US2020 - ANR-20-SFRI-0012 - SFRI - VALID, and Quantum Science and Nanomaterials - - QMAT2017 - ANR-17-EURE-0024 - EURE - VALID
Subjects: Condensed Matter - Materials Science, precession-assisted electron diffraction tomography, Polymers and Plastics, Metals and Alloys, Materials Science (cond-mat.mtrl-sci), FOS: Physical sciences, [PHYS.COND.CM-MS] Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], cationic mobility, Electronic, Optical and Magnetic Materials, high resolution scanning transmission electron microscopy, Functional oxides in thin films, Ceramics and Composites, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], spatially resolved EELS, non-conventional ferroelectricity
Abstract: International audience; Understanding the polarization switching mechanisms at play in ferroelectric materials is crucial for their exploitation in electronic devices. The conventional centrosymmetric reference structure-based mechanism which accounts for ferroelectricity in most of the usual displacive ferroelectric materials is too energy-demanding for some newly diagnosed ferroelectric materials such as the Ga2-xFexO3 (0.8 ≤ x ≤ 1.4) compounds. Some alternative theoretical propositions have been made and need experimental confirmation. A dual-scale electron microscopy study is performed on thin films of the Ga0.6Fe1.4O3 multiferroic compound. A wide scale precession-assisted electron diffraction tomography study first allows the determination of the structure the compound adopts in thin films, and even permits the refinement of the atomic positions within this structure. Cationic mobility is suggested for two of the atomic positions through the existence of extra electronic density. A local in situ high resolution scanning transmission electron microscopy study then allows confirming these mobilities by directly spotting the cationic displacements on successively acquired images. The whole study confirms an unconventional switching mechanism via local domain wall motion in this compound.
Published: 2022

23. Towards the engineering of a photon-only two-stroke rotary molecular motor

Author: Michael Filatov, Marco Paolino, Robin Pierron, Andrea Cappelli, Gianluca Giorgi, Jérémie Léonard, Miquel Huix-Rotllant, Nicolas Ferré, Xuchun Yang, Danil Kaliakin, Alejandro Blanco-González, Massimo Olivucci, Kyungpook National University [Daegu] (KNU), Università degli Studi di Siena = University of Siena (UNISI), Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie Radicalaire (ICR), Aix Marseille Université (AMU)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Bowling Green State University (BGSU), ANR-20-CE29-0021,PhotoMecha,Utiliser l'influence de l'environnement sur la photoréactivité, pour comprendre le mécanisme de photoisomérisation(2020), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), ANR-20-SFRI-0012,STRAT'US,Façonner les talents en formation et en recherche à l'Université de Strasbourg(2020), ANR-17-EURE-0024,QMAT,Quantum Science and Nanomaterials(2017), and ANR-11-LABX-0058,NIE,Nanostructures en Interaction avec leur Environnement(2011)
Subjects: [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, Stroke, Photons, Multidisciplinary, Rotation, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Humans, General Physics and Astronomy, General Chemistry, General Biochemistry, Genetics and Molecular Biology
Abstract: The rational engineering of photoresponsive materials, e.g., light-driven molecular motors, is a challenging task. Here, we use structure-related design rules to prepare a prototype molecular rotary motor capable of completing an entire revolution using, exclusively, the sequential absorption of two photons; i.e., a photon-only two-stroke motor. The mechanism of rotation is then characterised using a combination of non-adiabatic dynamics simulations and transient absorption spectroscopy measurements. The results show that the rotor moiety rotates axially relative to the stator and produces, within a few picoseconds at ambient T, an intermediate with the same helicity as the starting structure. We discuss how such properties, that include a 0.25 quantum efficiency, can help overcome the operational limitations of the classical overcrowded alkene designs.
Published: 2022

24. Ultrafast Dynamics of Solute Molecules Probed by Resonant Optical Kerr Effect Spectroscopy

Author: Soh Kushida, Kuidong Wang, Cyriaque Genet, Thomas W. Ebbesen, Institut de Science et d'ingénierie supramoléculaires (ISIS), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), International Center for Frontier Research in Chemistry [Strasbourg, France] (icFRC), Université de Tsukuba = University of Tsukuba, ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), European Project: 788482,MOLUSC, and univOAK, Archive ouverte
Subjects: Solutions, [CHIM.MATE] Chemical Sciences/Material chemistry, Spectrum Analysis, Solvents, General Materials Science, [CHIM.MATE]Chemical Sciences/Material chemistry, Physical and Theoretical Chemistry
Abstract: Ultrafast molecular dynamics in fluids is of great importance in many biological and chemical systems. Although such dynamics in bulk liquids has been explored by various methods, experimental tools that unveil the dynamics of solvated solutes are limited. In this work, we have developed resonant optical Kerr effect spectroscopy (ROKE), which is an analogue of optical Kerr effect spectroscopy that measures the reorientational relaxation of a dilute solute in solution. By adjusting the pump and probe wavelengths at the resonant absorption band of a solute, the time response of the solute was distinguished easily from the negligible signal of the solvent. The heterodyne detection of ROKE enables the determination of reorientational relaxation time constants with an accuracy of 2.6%. The signal-to-noise ratio was high enough (average ∼26.7) to obtain an adequate signal from even a 10 μM solution. Thus, ROKE is a powerful tool to study solute dynamics with high sensitivity in a broad range of applications.
Published: 2022

25. Quantitative fragmentomics allow affinity mapping of interactomes

Author: Gogl, Gergo, Tugaeva, Kristina, Eberling, Pascal, Kostmann, Camille, Trave, Gilles, Sluchanko, Nikolai, Zambo, Boglarka, Cousido-Siah, Alexandra, Morlet, Bastien, Durbesson, Fabien, Negroni, Luc, Jane, Pau, Nomine, Yves, Zeke, Andras, Østergaard, Søren, Monsellier, Elodie, Vincentelli, Renaud, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Architecture et fonction des macromolécules biologiques (AFMB), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Research Centre for Natural Sciences, Hungarian Academy of Sciences (MTA), Novo Nordisk Inc, NOVO NORDISK PARK, ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), ANR-17-EURE-0023,IMCBio,Integrative Molecular and Cellular Biology(2017), ANR-18-CE92-0017,UBE3A,Ubiquitine-ligase E6AP: Analyse structurale et modulation par de petites molécules.(2018), ANR-10-INBS-0005,FRISBI,Infrastructure Française pour la Biologie Structurale Intégrée(2010), ANR-20-SFRI-0012,STRAT'US,Façonner les talents en formation et en recherche à l'Université de Strasbourg(2020), Centre National de la Recherche Scientifique (CNRS), University of Strasbourg, CNRSITI 2021-2028, SFRI-STRAT'US projectANR 20-SFRI0012, Monsellier, Elodie, Initiative d'excellence - Par-delà les frontières, l'Université de Strasbourg - - UNISTRA2010 - ANR-10-IDEX-0002 - IDEX - VALID, and Integrative Molecular and Cellular Biology - - IMCBio2017 - ANR-17-EURE-0023 - EURE - VALID
Subjects: Cell Extracts, Proteome, PDZ domain, General Physics and Astronomy, PDZ Domains, [SDV.BBM.BP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics, Computational biology, Biology, Interactome, General Biochemistry, Genetics and Molecular Biology, Mass Spectrometry, 03 medical and health sciences, Human interactome, Humans, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Viral Interference, Papillomaviridae, [SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], 030304 developmental biology, 0303 health sciences, Multidisciplinary, 030302 biochemistry & molecular biology, General Chemistry, Affinities, 3. Good health, [SDV.BBM.BP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics, Protein network, Function (biology)
Abstract: Human protein networks have been widely explored but most binding affinities remain unknown, hindering quantitative interactome-function studies. Yet interactomes rely on minimal interacting fragments displaying quantifiable affinities. Here we measured the affinities of 65,000 interactions involving PDZ domains and their target PDZ-binding motifs (PBM) within a human interactome region particularly relevant for viral infection and cancer. We calculate interactomic distances, identify hot spots for viral interference, generate binding profiles and specificity logos, and explain selected cases by crystallographic studies. Mass spectrometry experiments on cell extracts and literature surveys show that quantitative fragmentomics effectively complement protein interactomics by providing affinities and completeness of coverage, putting a full human interactome affinity survey within realistic reach. Finally, we show that interactome hijacking by the viral PBM of human papillomavirus (HPV) E6 oncoprotein deeply impacts the host cell proteome way beyond immediate E6 binders, illustrating the complex system-wide relationship between interactome and function.
Published: 2022

26. Nanofloating gate modulated synaptic organic light-emitting transistors for reconfigurable displays

Author: Chen, Yusheng, Wang, Hanlin, Luo, Feng, Montes-García, Verónica, Liu, Zhaoyang, Samorì, Paolo, Institut de Science et d'ingénierie supramoléculaires (ISIS), Université Louis Pasteur - Strasbourg I-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), univOAK, Archive ouverte, Initiative d'excellence - Par-delà les frontières, l'Université de Strasbourg - - UNISTRA2010 - ANR-10-IDEX-0002 - IDEX - VALID, ANR-19-GRF1-0005,prospect,PatteRned cOatings based on 2D materials benzoxazine reSin hybrids for broad range Pressure detection(2019), European Project: 833707,SUPRA2DMAT, and European Project: 881603,H2020,H2020-SGA-FET-GRAPHENE-2019, GrapheneCore3(2020)
Subjects: [CHIM.MATE] Chemical Sciences/Material chemistry, Multidisciplinary, [CHIM.MATE]Chemical Sciences/Material chemistry
Abstract: International audience; The use of postsynaptic current to drive long-lasting luminescence holds a disruptive potential for harnessing the next-generation of smart displays. Multiresponsive long afterglow emission can be achieved by integrating light-emitting polymers in electric spiked transistors trigged by distinct presynaptic signals inputs. Here, we report a highly effective electric spiked long afterglow organic light-emitting transistor (LAOLET), whose operation relies on a nanofloating gate architecture. Long afterglow emission with reconfigurable brightness and retention time is observed upon applying specific positive gate voltage spiked. Conversely, when negative gate voltage stimulus is applied, these LAOLETs function as click-on display. Interestingly, upon endowing the device with force sensing capabilities, it can operate as a long afterglow pressure sensor that emits long-lasting green light subsequently to a controlled extrusion action.
Published: 2022

27. Keratinocyte-derived cytokine TSLP promotes growth and metastasis of melanoma by regulating the tumor-associated immune microenvironment

Author: Wenjin Yao, Beatriz German, Dounia Chraa, Antoine Braud, Cecile Hugel, Pierre Meyer, Guillaume Davidson, Patrick Laurette, Gabrielle Mengus, Eric Flatter, Pierre Marschall, Justine Segaud, Marine Guivarch, Pierre Hener, Marie-Christine Birling, Dan Lipsker, Irwin Davidson, Mei Li, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CHU Strasbourg, Institut Clinique de la Souris (ICS), ANR-19-CE17-0017,TARGET-NS,Développement d'une nouvelle biothérapie ciblant les mécanismes inflammatoires du syndrome de Netherton(2019), ANR-19-CE17-0021,BASIN,Cibler la voie IL-3 pour inhiber la fonction basophile en conditions inflammatoires(2019), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), ANR-20-SFRI-0012,STRAT'US,Façonner les talents en formation et en recherche à l'Université de Strasbourg(2020), ANR-17-EURE-0023,IMCBio,Integrative Molecular and Cellular Biology(2017), MENGUS, Gabrielle, Développement d'une nouvelle biothérapie ciblant les mécanismes inflammatoires du syndrome de Netherton - - TARGET-NS2019 - ANR-19-CE17-0017 - AAPG2019 - VALID, Cibler la voie IL-3 pour inhiber la fonction basophile en conditions inflammatoires - - BASIN2019 - ANR-19-CE17-0021 - AAPG2019 - VALID, Initiative d'excellence - Par-delà les frontières, l'Université de Strasbourg - - UNISTRA2010 - ANR-10-IDEX-0002 - IDEX - VALID, Façonner les talents en formation et en recherche à l'Université de Strasbourg - - STRAT'US2020 - ANR-20-SFRI-0012 - SFRI - VALID, and Integrative Molecular and Cellular Biology - - IMCBio2017 - ANR-17-EURE-0023 - EURE - VALID
Subjects: Keratinocytes, [SDV] Life Sciences [q-bio], Mice, Skin Neoplasms, Thymic Stromal Lymphopoietin, [SDV]Life Sciences [q-bio], Tumor Microenvironment, Humans, Animals, Cytokines, General Medicine, Melanoma
Abstract: International audience; Malignant melanoma is a major public health issue displaying frequent resistance to targeted therapy and immunotherapy. A major challenge lies in better understanding how melanoma cells evade immune elimination and how tumor growth and metastasis is facilitated by the tumor microenvironment. Here, we show that expression of the cytokine thymic stromal lymphopoietin (TSLP) by epidermal keratinocytes is induced by cutaneous melanoma in both mice and humans. Using genetically engineered models of melanoma and tumor cell grafting combined with TSLP-KO or overexpression, we defined a crosstalk between melanoma cells, keratinocytes, and immune cells in establishing a tumor-promoting microenvironment. Keratinocyte-derived TSLP is induced by signals derived from melanoma cells and subsequently acts via immune cells to promote melanoma progression and metastasis. Furthermore, we show that TSLP signals through TSLP receptor-expressing (TSLPR-expressing) DCs to play an unrecognized role in promoting GATA3+ Tregs expressing a gene signature including ST2, CCR8, ICOS, PD-1, CTLA-4, and OX40 and exhibiting a potent suppressive activity on CD8+ T cell proliferation and IFN-γ production. An analogous population of GATA3-expressing Tregs was also identified in human melanoma tumors. Our study provides insights into the role of TSLP in programming a protumoral immune microenvironment in cutaneous melanoma.
Published: 2022

28. Origin of Zenneck-like waves excited by optical nanoantennas in non-plasmonic transition metals

Author: Juemin Yi, Fernando de León-Pérez, Aurélien Cuche, Eloïse Devaux, Cyriaque Genet, Luis Martín-Moreno, Thomas W. Ebbesen, International Center for Frontier Research in Chemistry [Strasbourg, France] (icFRC), Suzhou Institute of Nano-Tech and Nano-Bionics (SINANO), Institut de Science et d'ingénierie supramoléculaires (ISIS), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Centro Universitario de la Defensa de Zaragoza (CUD), General Military Academy of Zaragoza, Centre d'élaboration de matériaux et d'études structurales (CEMES), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut de Chimie de Toulouse (ICT-FR 2599), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Instituto de Nanociencia y Materiales de Aragón (INMA), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Universidad de Zaragossa, ANR-20-SFRI-0012,STRAT'US,Façonner les talents en formation et en recherche à l'Université de Strasbourg(2020), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), University of Science & Technology of China [Suzhou], Nano-Optique et Nanomatériaux pour l'optique (CEMES-NeO), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut de Chimie de Toulouse (ICT), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Departamento de Fisica de la Materia Condensada [Madrid] (FMC), Facultad de Ciencas [Madrid], Universidad Autónoma de Madrid (UAM)-Universidad Autónoma de Madrid (UAM), J.Y. acknowledges the support of the Natural Science Foundation of China (Grant No.62174175). L.M.M. acknowledges Project PID2020-115221GB-C41 financed by MCIN/AEI/10.13039/501100011033. F.d.L.P. acknowledges financial support from Spanish Ministry of Science, Innovation and Universities - State Research Agency through project MAT2017-88358-C3-2-R. L.M.M. and F.d.L.P. acknowledge the Aragon Government through Project Q-MAD, ANR-10-LABX-0026,CSC,Center of Chemistry of Complex System(2010), ANR-11-LABX-0058,NIE,Nanostructures en Interaction avec leur Environnement(2011), Université de Strasbourg, Agence Nationale de la Recherche (France), Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission, National Natural Science Foundation of China, and Gobierno de Aragón
Subjects: [PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics], [PHYS.COND]Physics [physics]/Condensed Matter [cond-mat], [PHYS.PHYS.PHYS-GEN-PH]Physics [physics]/Physics [physics]/General Physics [physics.gen-ph], Atomic and Molecular Physics, and Optics
Abstract: The scattering properties of metallic optical antennas are typically examined through the lens of their plasmonic resonances. However, non-plasmonic transition metals also sustain surface waves in the visible. We experimentally investigate in this work the far-field diffraction properties of apertured optical antennas milled on non-plasmonic W films and compare the results with plasmonic references in Ag and Au. The polarization-dependent diffraction patterns and the leakage signal emerging from apertured antennas in both kinds of metals are recorded and analyzed. This thorough comparison with surface plasmon waves reveals that surface waves are launched on W and that they have the common abilities to confine the visible light at metal-dielectric interfaces offering the possibility to tailor the far-field emission. The results have been analyzed through theoretical models accounting for the propagation of a long range surface mode launched by subwavelength apertures, that is scattered in free space by the antenna. This surface mode on W can be qualitatively described as an analogy in the visible of the Zenneck wave in the radio regime. The nature of the new surface waves have been elucidated from a careful analysis of the asymptotic expansion of the electromagnetic propagators, which provides a convenient representation for explaining the Zenneck-like character of the excited waves and opens new ways to fundamental studies of surface waves at the nanoscale beyond plasmonics., University of Strasbourg Institute for Advanced Study (USIAS) (ANR-10-IDEX- 0002-02); SFRI STRATUS (ANR-20-SFRI-0012); IdEx Unistra (ANR-10-IDEX- 0002); Spanish Ministry of Science, Innovation and Universities - State Research Agency (MAT2017-88358-C3-2-R); Ministerio de Ciencia e Innovación/Agencia Estatal de Investigación (MICINN/AEI) (PID2020-115221GB-C41); National Natural Science Foundation of China (62174175); LabEx Chimie des Systèmes Complexes (ANR-10-LABX- 0026-CSC); Laboratoires d'excellence Nanostructures en Interaction avec leur Environnement (ANR-11-LABX-0058-NIE).
Published: 2022

29. Single-shot off-axis full-field optical coherence tomography

Author: Emmanuel Martins Seromenho, Agathe Marmin, Sybille Facca, Nadia Bahlouli, Stephane Perrin, Amir Nahas, Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), and ANR-20-SFRI-0012,STRAT'US,Façonner les talents en formation et en recherche à l'Université de Strasbourg(2020)
Subjects: Physics and Astronomy (miscellaneous), [INFO.INFO-IM]Computer Science [cs]/Medical Imaging
Abstract: Full field optical coherence tomography (FF-OCT) enables high-resolution in-depth imaging within turbid media. In this work, we present a simple approach which combines FF-OCT with off-axis interferometry for the reconstruction of the en-face images. With low spatial and temporal coherence illumination, this new method is able to extract an FF-OCT image from only one interference acquisition. This method is described and the proof-of-concept is demonstrated through the observation of scattering samples such as organic and ex-vivo biomedical samples.
Published: 2022

30. OR black box and surgical control tower: Recording and streaming data and analytics to improve surgical care

Author: Pietro Mascagni, Nicolas Padoy, Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt), ANR-11-LABX-0004,CAMI,Gestes Médico-Chirurgicaux Assistés par Ordinateur(2011), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), ANR-10-IAHU-0002,MIX-Surg,Institut de Chirurgie Mini-Invasive guidée par l'Image(2010), and ANR-16-CE33-0009,DeepSurg,Apprentissage Profond à partir de Vidéos Chirurgicales Multi-vues et Multimodales pour Faciliter la Gestion du Bloc Opératoire(2016)
Subjects: Surgeons, Operating Rooms, Sociotechnical system, business.industry, Process (engineering), Human error, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, Context (language use), General Medicine, Workflow, 3. Good health, 03 medical and health sciences, Engineering management, 0302 clinical medicine, Artificial Intelligence, Analytics, 030220 oncology & carcinogenesis, Black box, Humans, Medicine, 030211 gastroenterology & hepatology, [INFO.INFO-BT]Computer Science [cs]/Biotechnology, business, Set (psychology)
Abstract: Effective and safe surgery results from a complex sociotechnical process prone to human error. Acquiring large amount of data on surgical care and modelling the process of surgery with artificial intelligence's computational methods could shed lights on system strengths and limitations and enable computer-based smart assistance. With this vision in mind, surgeons and computer scientists have joined forces in a novel discipline called Surgical Data Science. In this regard, operating room (OR) black boxes and surgical control towers are being developed to systematically capture comprehensive data on surgical procedures and to oversee and assist during operating rooms activities, respectively. Most of the early Surgical Data Science works have focused on understanding risks and resilience factors affecting surgical safety, the context and workflow of procedures, and team behaviors. These pioneering efforts in sensing and analyzing surgical activities, together with the advent of precise robotic actuators, bring surgery on the verge of a fourth revolution characterized by smart assistance in perceptual, cognitive and physical tasks. Barriers to implement this vision exist, but the surgical-technical partnerships set by ambitious efforts such as the OR black box and the surgical control tower are working to overcome these roadblocks and translate the vision and early works described in the manuscript into value for patients, surgeons and health systems.
Published: 2021

31. Hypoxia-mediated stabilization of HIF1A in prostatic intraepithelial neoplasia promotes cell plasticity and malignant progression

Author: Mohamed A. Abu el Maaty, Julie Terzic, Céline Keime, Daniela Rovito, Régis Lutzing, Darya Yanushko, Maxime Parisotto, Elise Grelet, Izzie Jacques Namer, Véronique Lindner, Gilles Laverny, Daniel Metzger, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Les Hôpitaux Universitaires de Strasbourg (HUS), metzger, daniel, ANR-10-INBS-0009,France-Génomique,Organisation et montée en puissance d'une Infrastructure Nationale de Génomique(2010), ANR-10-LABX-0030,INRT,Integrative Biology : Nuclear dynamics- Regenerative medicine - Translational medicine(2010), and ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010)
Subjects: Male, Prostatic Intraepithelial Neoplasia, Multidisciplinary, MESH: Humans, MESH: Prostatic Intraepithelial Neoplasia, [SDV]Life Sciences [q-bio], Cell Plasticity, Prostatic Neoplasms, MESH: Cell Plasticity, Hypoxia-Inducible Factor 1, alpha Subunit, MESH: Hypoxia-Inducible Factor 1, alpha Subunit, MESH: Male, [SDV] Life Sciences [q-bio], Mice, MESH: Hypoxia, MESH: Prostatic Neoplasms, Disease Progression, Animals, Humans, MESH: Animals, MESH: Disease Progression, Hypoxia, MESH: Mice
Abstract: Prostate cancer (PCa) is a leading cause of cancer-related deaths. The slow evolution of precancerous lesions to malignant tumors provides a broad time frame for preventing PCa. To characterize prostatic intraepithelial neoplasia (PIN) progression, we conducted longitudinal studies on Pten (i)pe−/− mice that recapitulate prostate carcinogenesis in humans. We found that early PINs are hypoxic and that hypoxia-inducible factor 1 alpha (HIF1A) signaling is activated in luminal cells, thus enhancing malignant progression. Luminal HIF1A dampens immune surveillance and drives luminal plasticity, leading to the emergence of cells that overexpress Transglutaminase 2 (TGM2) and have impaired androgen signaling. Elevated TGM2 levels in patients with PCa are associated with shortened progression-free survival after prostatectomy. Last, we show that pharmacologically inhibiting HIF1A impairs cell proliferation and induces apoptosis in PINs. Therefore, our study demonstrates that HIF1A is a target for PCa prevention and that TGM2 is a promising prognostic biomarker of early relapse after prostatectomy.
Published: 2022

32. The Role of Denial in Vaccine Skeptics and 'Anti-vax' Blame: A Psychodynamic Approach

Author: Olivier, Putois, Julie, Helms, Subjéctivité, lien social et modernité (SULISOM), Université de Strasbourg (UNISTRA), Les Hôpitaux Universitaires de Strasbourg (HUS), LabEx Transplantex [Strasbourg], Nouvel Hôpital Civil de Strasbourg, Nanomédecine Régénérative (NanoRegMed), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Fédération de Médecine Translationnelle de Strasbourg (FMTS), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), ANR-20-SFRI-0012,STRAT'US,Façonner les talents en formation et en recherche à l'Université de Strasbourg(2020), univOAK, Archive ouverte, Initiative d'excellence - Par-delà les frontières, l'Université de Strasbourg - - UNISTRA2010 - ANR-10-IDEX-0002 - IDEX - VALID, and Façonner les talents en formation et en recherche à l'Université de Strasbourg - - STRAT'US2020 - ANR-20-SFRI-0012 - SFRI - VALID
Subjects: fetishism, risk perception, [SCCO.PSYC]Cognitive science/Psychology, [SCCO.PSYC] Cognitive science/Psychology, Sciences cognitives/Psychologie, vaccine skepticism, COVID-19, anti-vax, self-preservation, selfishness, General Psychology, denial
Abstract: In this paper, we propose to account for the blame addressed to vaccine skeptics and “anti-vax” (VS and AV) by considering their attitude as the result of the psychological mechanism of denial, understood in a psychodynamic manner. To that effect, we draw on a secondary account of our clinical experience in two hospital units (psychiatry and intensive care unit), and on openly available media material. First, we lay out how VS and AV can be understood as the result from fetishist risk denial, a specific psychological transaction with an object by which VS and AV people feel intimately protected; this object is viewed as so powerful that its protection makes the vaccine appear irrelevant. Second, we show how this mechanism can explain the specific content of the blame frequently addressed to VS and AV, who are reproached with being selfish by vaccinated people and caregivers. We contend that, contrary to common belief, they are thus blamed because they force others (and especially caregivers) to compensate their lack of self-protection and preservation, which derives from their exclusive relation to an almighty object. While such a relation accounts for the unwillingness to consider vaccination, it also explains the harshness of the blame voiced by caregivers, who feel helpless in most situations as they cannot effectively force VS and AV to take care of themselves and others.
Published: 2022

33. MoS2 Defect Healing for High-Performance Chemical Sensing of Polycyclic Aromatic Hydrocarbons

Author: Fernando Jiménez Urbanos, Paolo Samorì, Sara Gullace, Institut de Science et d'ingénierie supramoléculaires (ISIS), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), univOAK, Archive ouverte, ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), European Project: 833707,SUPRA2DMAT, European Project: 881603,H2020,H2020-SGA-FET-GRAPHENE-2019, GrapheneCore3(2020), and European Project: 813036,ULTIMATE
Subjects: [CHIM.MATE] Chemical Sciences/Material chemistry, General Engineering, General Physics and Astronomy, General Materials Science, [CHIM.MATE]Chemical Sciences/Material chemistry
Abstract: International audience; The increasing population and industrial development are responsible for environmental pollution. Among toxic chemicals, polycyclic aromatic hydrocarbons (PAHs) are highly carcinogenic contaminants resulting from the incomplete combustion of organic materials. Two-dimensional materials, such as transition metal dichalcogenides (TMDCs), are ideal sensory scaffolds, combining high surface-to-volume ratio with physical and chemical properties that are strongly susceptible to environmental changes. TMDCs can be integrated in field-effect transistors (FETs), which can operate as high-performance chemical detectors of (non)covalent interaction with small molecules. Here, we have developed MoS2-based FETs as platforms for PAHs sensing, relying on the affinity of the planar polyaromatic molecules for the basal plane of MoS2 and the structural defects in its lattice. X-ray photoelectron spectroscopy analysis, photoluminescence measurements, and transfer characteristics showed a notable reduction in the defectiveness of MoS2 and a p-type doping upon exposure to PAHs solutions, with a magnitude determined by the correlation between the ionization energies (EI) of the PAH and that of MoS2. Naphthalene, endowed with the higher EI among the studied PAHs, exhibited the highest output. We observed a log–log correlation between MoS2 doping and naphthalene concentration in water in a wide range (10–9–10–6 M), as well as a reversible response to the analyte. Naphthalene concentrations as low as 0.128 ppb were detected, being below the limits imposed by health regulations for drinking water. Furthermore, our MoS2 devices can reversibly detect vapors of naphthalene with both an electrical and optical readout, confirming that our architecture could operate as a dual sensing platform.
Published: 2022

34. The Human SCN9AR185H Point Mutation Induces Pain Hypersensitivity and Spontaneous Pain in Mice

Author: Yaping Xue, Mélanie Kremer, Maria del Mar Muniz Moreno, Celeste Chidiac, Romain Lorentz, Marie-Christine Birling, Michel Barrot, Yann Herault, Claire Gaveriaux-Ruff, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut des Neurosciences Cellulaires et Intégratives (INCI), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Institut Clinique de la Souris (ICS), CELPHEDIA, Centre National de la Recherche Scientifique (CNRS), French National Infrastructure for Mouse Phenogenomics (PHENOMIN), Biotechnologie et signalisation cellulaire (BSC), Université de Strasbourg (UNISTRA)-Institut de recherche de l'Ecole de biotechnologie de Strasbourg (IREBS)-Centre National de la Recherche Scientifique (CNRS), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), ANR-10-LABX-0030,INRT,Integrative Biology : Nuclear dynamics- Regenerative medicine - Translational medicine(2010), ANR-17-EURE-0022,EURIDOL,Ecole Universitaire de Recherche Interdisciplinaire sur la Douleur(2017), and European Project: 721841
Subjects: Gdaphen, [SDV.GEN]Life Sciences [q-bio]/Genetics, Science & Technology, SCN9A, statistical modeling, spontaneous pain, data analysis, Aucun, Neurosciences, SODIUM-CHANNELS, NA(V)1.7, SMALL FIBER NEUROPATHY, VARIANTS, Cellular and Molecular Neuroscience, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], pain, Neurosciences & Neurology, nociception, Life Sciences & Biomedicine, NEURONS, Molecular Biology, sodium channel, gdaphen
Abstract: The voltage-gated sodium channel Nav1.7 is encoded by SCN9A gene and plays a critical role in pain sensitivity. Several SCN9A gain-of-function (GOF) mutations have been found in patients with small fiber neuropathy (SFN) having chronic pain, including the R185H mutation. However, for most of these variants, their involvement in pain phenotype still needs to be experimentally elucidated. In order to delineate the impact of R185H mutation on pain sensitivity, we have established the Scn9aR185H mutant mouse model using the CRISPR/Cas9 technology. The Scn9aR185H mutant mice show no cellular alteration in the dorsal root ganglia (DRG) containing cell bodies of sensory neurons and no alteration of growth or global health state. Heterozygous and homozygous animals of both sexes were investigated for pain sensitivity. The mutant mice were more sensitive than the wild-type mice in the tail flick and hot plate tests, acetone, and von Frey tests for sensitivity to heat, cold, and touch, respectively, although with sexual dimorphic effects. The newly developed bioinformatic pipeline, Gdaphen is based on general linear model (GLM) and random forest (RF) classifiers as well as a multifactor analysis of mixed data and shows the qualitative and quantitative variables contributing the most to the pain phenotype. Using Gdaphen, tail flick, Hargreaves, hot plate, acetone, cold plate, and von Frey tests, sex and genotype were found to be contributing most to the pain phenotype. Importantly, the mutant animals displayed spontaneous pain as assessed in the conditioned place preference (CPP) assay. Altogether, our results indicate that Scn9aR185H mice show a pain phenotype, suggesting that the SCN9AR185H mutation identified in patients with SFN having chronic pain contributes to their symptoms. Therefore, we provide genetic evidence for the fact that this mutation in Nav1.7 channel plays an important role in nociception and in the pain experienced by patients with SFN who have this mutation. These findings should aid in exploring further pain treatments based on the Nav1.7 channel.
Published: 2022
Full Text: View/download PDF

35. Room temperature optoelectronic devices operating with spin crossover nanoparticles

Author: Marlène Palluel, Bernard Doudin, Jean-Francois Dayen, Nikita Konstantinov, Guillaume Chastanet, Nathalie Daro, Bohdan Kundys, Mohamed Soliman, Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), Université de Strasbourg (UNISTRA)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Institut de Chimie de la Matière Condensée de Bordeaux (ICMCB), Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), The financial support from the Agence Nationale de la Recherche (HEROES ANR-17-CE09-0010-01, MIXES ANR-19-CE09-0028) is acknowledged as well as that from the CNRS, University of Bordeaux, and Nouvelle Aquitaine Region. This work of the Interdisciplinary Thematic Institute QMat, as part of the ITI 2021 2028 program of the University of Strasbourg, CNRS and Inserm, was supported by IdEx Unistra (ANR 10 IDEX 0002), and by SFRI STRAT’US project (ANR 20 SFRI 0012) and EUR QMat ANR-18-EUR-0016 under the framework of the French Investments for the Future Program. The Institut Universitaire de France (IUF) for financial support., ANR-17-CE09-0010,HEROES,Nanomatériaux hybrides pour une commutation photo-thermique contrôlée(2017), ANR-19-CE09-0028,MIXES,Hétérostructures de van der Waals à dimensions mixtes pour l'électronique et la spintronique(2019), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), ANR-20-SFRI-0012,STRAT'US,Façonner les talents en formation et en recherche à l'Université de Strasbourg(2020), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Toulin, Stéphane, Nanomatériaux hybrides pour une commutation photo-thermique contrôlée - - HEROES2017 - ANR-17-CE09-0010 - AAPG2017 - VALID, Hétérostructures de van der Waals à dimensions mixtes pour l'électronique et la spintronique - - MIXES2019 - ANR-19-CE09-0028 - AAPG2019 - VALID, Initiative d'excellence - Par-delà les frontières, l'Université de Strasbourg - - UNISTRA2010 - ANR-10-IDEX-0002 - IDEX - VALID, and Façonner les talents en formation et en recherche à l'Université de Strasbourg - - STRAT'US2020 - ANR-20-SFRI-0012 - SFRI - VALID
Subjects: Materials science, Spin states, Spin transition, Nanoparticle, 02 engineering and technology, Conductivity, 010402 general chemistry, 01 natural sciences, law.invention, Spin crossover, law, Metastability, Molecule, General Materials Science, Electrical and Electronic Engineering, [CHIM.MATE] Chemical Sciences/Material chemistry, business.industry, Graphene, Process Chemistry and Technology, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Mechanics of Materials, Optoelectronics, 0210 nano-technology, business
Abstract: International audience; Molecular systems can exhibit multi-stimuli switching of their properties, with spin crossover materials having unique magnetic transition triggered by temperature and light, among others. Light-induced room temperature operation is however elusive, as optical changes between metastable spin states require cryogenic temperatures. Furthermore, electrical detection is hampered by the intrinsic low conductivity properties of these materials. We show here how a graphene underlayer reveals the light-induced heating that triggers a spin transition, paving the way for using these molecules for room temperature optoelectronic applications.
Published: 2021

36. Nuclear pore complex acetylation regulates mRNA export and cell cycle commitment in budding yeast

Author: Mercè Gomar‐Alba, Vasilisa Pozharskaia, Bogdan Cichocki, Celia Schaal, Arun Kumar, Basile Jacquel, Gilles Charvin, J Carlos Igual, Manuel Mendoza, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de Génétique et de Biologie Microbiennes (IGBM), Université de Lausanne = University of Lausanne (UNIL), Barcelona Institute of Science and Technology (BIST), Universitat Pompeu Fabra [Barcelona] (UPF), Universitat de València (UV), ANR-10-LABX-0030,INRT,Integrative Biology : Nuclear dynamics- Regenerative medicine - Translational medicine(2010), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), Mendoza, Manuel, Integrative Biology : Nuclear dynamics- Regenerative medicine - Translational medicine - - INRT2010 - ANR-10-LABX-0030 - LABX - VALID, and Initiative d'excellence - Par-delà les frontières, l'Université de Strasbourg - - UNISTRA2010 - ANR-10-IDEX-0002 - IDEX - VALID
Subjects: Saccharomyces cerevisiae Proteins, General Immunology and Microbiology, [SDV]Life Sciences [q-bio], General Neuroscience, Cell Cycle, Active Transport, Cell Nucleus, Acetylation, Saccharomyces cerevisiae, General Biochemistry, Genetics and Molecular Biology, Histone Deacetylases, [SDV] Life Sciences [q-bio], Nuclear Pore Complex Proteins, Saccharomycetales, Nuclear Pore, RNA, Messenger, Molecular Biology, ComputingMilieux_MISCELLANEOUS, Histone Acetyltransferases
Abstract: Nuclear pore complexes (NPCs) mediate communication between the nucleus and the cytoplasm, and regulate gene expression by interacting with transcription and mRNA export factors. Lysine acetyltransferases (KATs) promote transcription through acetylation of chromatin-associated proteins. We find that Esa1, the KAT subunit of the yeast NuA4 complex, also acetylates the nuclear pore basket component Nup60 to promote mRNA export. Acetylation of Nup60 recruits the mRNA export factor Sac3, the scaffolding subunit of the Transcription and Export 2 (TREX-2) complex, to the nuclear basket. The Esa1-mediated nuclear export of mRNAs in turn promotes entry into S phase, which is inhibited by the Hos3 deacetylase in G1 daughter cells to restrain their premature commitment to a new cell division cycle. This mechanism is not only limited to G1/S-expressed genes but also inhibits the expression of the nutrient-regulated GAL1 gene specifically in daughter cells. Overall, these results reveal how acetylation can contribute to the functional plasticity of NPCs in mother and daughter yeast cells. In addition, our work demonstrates dual gene expression regulation by the evolutionarily conserved NuA4 complex, at the level of transcription and at the stage of mRNA export by modifying the nucleoplasmic entrance to nuclear pores.
Published: 2022

37. A Magnetocaloric Glass from an Ionic‐Liquid Gadolinium Complex

Author: Seda Kartal, Guillaume Rogez, Jérôme Robert, Benoît Heinrich, Athanassios K. Boudalis, Institut de Chimie de Strasbourg, Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), University hospital of Zurich [Zurich], ANR-11-LABX-0058,NIE,Nanostructures en Interaction avec leur Environnement(2011), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), European Project: 746060,CHIRALQUBIT, and Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et nanosciences d'Alsace (FMNGE)
Subjects: Aucun, Physical and Theoretical Chemistry, [CHIM.INOR]Chemical Sciences/Inorganic chemistry, Atomic and Molecular Physics, and Optics
Abstract: International audience
Published: 2022

38. A comparative methylome analysis reveals conservation and divergence of DNA methylation patterns and functions in vertebrates

Author: Hala Al Adhami, Anaïs Flore Bardet, Michael Dumas, Elouan Cleroux, Sylvain Guibert, Patricia Fauque, Hervé Acloque, Michael Weber, Biotechnologie et signalisation cellulaire (BSC), Université de Strasbourg (UNISTRA)-Institut de recherche de l'Ecole de biotechnologie de Strasbourg (IREBS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Biologie de la reproduction CECOS - [CHU de Dijon], Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Génétique Animale et Biologie Intégrative (GABI), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), ANR-20-SFRI-0012,STRAT'US,Façonner les talents en formation et en recherche à l'Université de Strasbourg(2020), ANR-10-INBS-0009,France-Génomique,Organisation et montée en puissance d'une Infrastructure Nationale de Génomique(2010), and European Project: 615371,EC:FP7:ERC,ERC-2013-CoG,TRANSMETH(2014)
Subjects: Genomic imprinting, Swine, Physiology, Germline genes, Plant Science, General Biochemistry, Genetics and Molecular Biology, Epigenome, Mice, Dogs, Structural Biology, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Animals, Ecology, Evolution, Behavior and Systematics, Mammals, Genome, [SDV.BA]Life Sciences [q-bio]/Animal biology, 5mC, Cell Biology, DNA Methylation, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], Germ Cells, Vertebrates, CpG island, Cattle, CpG Islands, Female, Rabbits, General Agricultural and Biological Sciences, Developmental Biology, Biotechnology
Abstract: Background Cytosine DNA methylation is a heritable epigenetic mark present in most eukaryotic groups. While the patterns and functions of DNA methylation have been extensively studied in mouse and human, their conservation in other vertebrates remains poorly explored. In this study, we interrogated the distribution and function of DNA methylation in primary fibroblasts of seven vertebrate species including bio-medical models and livestock species (human, mouse, rabbit, dog, cow, pig, and chicken). Results Our data highlight both divergence and conservation of DNA methylation patterns and functions. We show that the chicken genome is hypomethylated compared to other vertebrates. Furthermore, compared to mouse, other species show a higher frequency of methylation of CpG-rich DNA. We reveal the conservation of large unmethylated valleys and patterns of DNA methylation associated with X-chromosome inactivation through vertebrate evolution and make predictions of conserved sets of imprinted genes across mammals. Finally, using chemical inhibition of DNA methylation, we show that the silencing of germline genes and endogenous retroviruses (ERVs) are conserved functions of DNA methylation in vertebrates. Conclusions Our data highlight conserved properties of DNA methylation in vertebrate genomes but at the same time point to differences between mouse and other vertebrate species.
Published: 2022

39. Signaling Induced by Chronic Viral Hepatitis: Dependence and Consequences

Author: Zakaria Boulahtouf, Alessia Virzì, Thomas F. Baumert, Eloi R. Verrier, Joachim Lupberger, Institut de Recherche sur les Maladies Virales et Hépatiques (IVH), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'hépato-gastroentérologie, CHU Strasbourg-Hopital Civil, Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), ANR-21-CE15-0035,DELTArget,Caractérisation de facteur cellulaires impliqués dans l'infection par le virus de l'hépatite D pour la caractérisation de nouvelles cibles antivirales(2021), ANR-10-IAHU-0002,MIX-Surg,Institut de Chirurgie Mini-Invasive guidée par l'Image(2010), ANR-10-LABX-0028,HepSys,Functional genomics of viral hepatitis and liver disease(2010), ANR-20-SFRI-0012,STRAT'US,Façonner les talents en formation et en recherche à l'Université de Strasbourg(2020), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), ANR-17-EURE-0023,IMCBio,Integrative Molecular and Cellular Biology(2017), European Project: 671231,H2020,ERC-2014-ADG,HEPCIR(2016), European Project: 667273,H2020,H2020-PHC-2015-two-stage,HEP-CAR(2016), and European Project: 862551,HEPCAN
Subjects: Hepatitis B virus, Carcinoma, Hepatocellular, Hepatitis, Viral, Human, viruses, Sciences du Vivant [q-bio]/Médecine humaine et pathologie, liver, HBV HCV HDV liver inflammation oxidative stress metabolic disease fibrosis cancer, Catalysis, Inorganic Chemistry, HDV, HBV, oxidative stress, cancer, Humans, Physical and Theoretical Chemistry, Molecular Biology, Spectroscopy, Hepatitis, Chronic, fibrosis, Organic Chemistry, Liver Neoplasms, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, General Medicine, Chlamydia Infections, metabolic disease, Hepatitis B, Computer Science Applications, inflammation, HCV, pathology, Hepatitis Delta Virus
Abstract: Chronic viral hepatitis is a main cause of liver disease and hepatocellular carcinoma. There are striking similarities in the pathological impact of hepatitis B, C, and D, although these diseases are caused by very different viruses. Paired with the conventional study of protein-host interactions, the rapid technological development of -omics and bioinformatics has allowed highlighting the important role of signaling networks in viral pathogenesis. In this review, we provide an integrated look on the three major viruses associated with chronic viral hepatitis in patients, summarizing similarities and differences in virus-induced cellular signaling relevant to the viral life cycles and liver disease progression. journal article review 2022 Mar 03 2022 03 03 imported
Published: 2022

40. Vector Fields and Genus in Dimension 3

Author: Pierre Dehornoy, Ana Rechtman, Institut Fourier (IF), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Institut de Recherche Mathématique Avancée (IRMA), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), UMI LaSol, ANR-15-IDEX-02,UGA,IDEX UGA(2016), ANR-11-LABX-0025-01,PERSYVAL-lab,Systèmes et Algorithmes Pervasifs au confluent des mondes physique et numérique(2011), ANR-10-IDEX-0002-02/10-IDEX-0002,UNISTRA,UNISTRA(2010), ANR-15-IDEX-0002,UGA,IDEX UGA(2015), ANR-11-LABX-0025,PERSYVAL-lab,Systemes et Algorithmes Pervasifs au confluent des mondes physique et numérique(2011), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), Institut Fourier [1973-2019] (IF [1973-2019]), and Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])
Subjects: General Mathematics, [MATH.MATH-DS]Mathematics [math]/Dynamical Systems [math.DS], 010102 general mathematics, Mathematical analysis, Geometric Topology (math.GT), Dynamical Systems (math.DS), 01 natural sciences, Homology sphere, Helicity, 010101 applied mathematics, Mathematics - Geometric Topology, symbols.namesake, Transverse plane, [MATH.MATH-GT]Mathematics [math]/Geometric Topology [math.GT], Euler characteristic, FOS: Mathematics, symbols, Ergodic theory, Vector field, Invariant measure, Mathematics - Dynamical Systems, 0101 mathematics, Invariant (mathematics), Mathematics
Abstract: Given a vector field on a 3D rational homology sphere, we give a formula for the Euler characteristic of its transverse surfaces, in terms of boundary data only. This provides a formula for the genus of a transverse surface, and in particular, of a Birkhoff section. As an application, we show that for a right-handed flow with an ergodic invariant measure, the genus is an asymptotic invariant of order 2 proportional to helicity.
Published: 2020

41. Structural basis of transcription-translation coupling and collision in bacteria

Author: Michael W. Webster, Albert Weixlbaumer, Maria Takacs, Vita Vidmar, Ayesha Dinshaw Eduljee, Chengjin Zhu, Mo’men Abdelkareem, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), ANR-10-LABX-0030,INRT,Integrative Biology : Nuclear dynamics- Regenerative medicine - Translational medicine(2010), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), and European Project: 653706,H2020,H2020-INFRAIA-2014-2015,iNEXT(2015)
Subjects: 0303 health sciences, Messenger RNA, Multidisciplinary, biology, Cryo-electron microscopy, Chemistry, 030302 biochemistry & molecular biology, RNA, biology.organism_classification, Ribosome, Cell biology, Future study, 03 medical and health sciences, chemistry.chemical_compound, Ribosome Subunits, Transcription (biology), RNA polymerase, Protein biosynthesis, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Transcription factor, Bacteria, 030304 developmental biology
Abstract: Prokaryotic messenger RNAs (mRNAs) are translated as they are transcribed. The pioneering ribosome potentially contacts RNA polymerase (RNAP), forming a supramolecular complex known as the expressome. The basis of expressome assembly and its consequences for transcription and translation are poorly understood. Here we present a series of structures representing uncoupled, coupled and collided expressome states determined by electron cryomicroscopy. A bridge between the ribosome and RNAP can be formed by the transcription factor NusG, stabilizing an otherwise variable interaction interface. Shortening of the intervening mRNA causes a substantial rearrangement that aligns the ribosome entrance-channel to the RNAP exit-channel. In this collided complex, NusG-linkage is no longer possible.These structures reveal mechanisms of coordination between transcription and translation and provide a framework for future study.One Sentence SummaryStructures of the molecular assembly executing gene expression shed light on transcription translation coupling.
Published: 2020

42. Pby1 is a direct partner of the Dcp2 decapping enzyme

Author: Loreline Cosson, Bertrand Séraphin, Clément Charenton, Claudine Gaudon-Plesse, Nathalie Ulryck, Régis Back, Marc Graille, Arnoux, Aurélien, BLANC - Mécanisme de clivage de la coiffe des ARNm eucaryotes - - Decapping2011 - ANR-11-BSV8-0009 - BLANC - VALID, Initiative d'excellence - Par-delà les frontières, l'Université de Strasbourg - - UNISTRA2010 - ANR-10-IDEX-0002 - IDEX - VALID, Laboratoire de Biologie Structurale de la Cellule (BIOC), École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Ligue Contre le Cancer (Equipe Labellisée 2020), Ecole Polytechnique, Centre National pour la Recherche Scientifique, CERBM-IGBMC, INSERM, ANR-11-BSV8-0009,Decapping,Mécanisme de clivage de la coiffe des ARNm eucaryotes(2011), and ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010)
Subjects: Models, Molecular, Saccharomyces cerevisiae Proteins, AcademicSubjects/SCI00010, Mutant, Protein domain, Saccharomyces cerevisiae, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Plasma protein binding, Biology, [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Ligases, 03 medical and health sciences, Adenosine Triphosphate, 0302 clinical medicine, Protein Domains, Structural Biology, Catalytic Domain, Endopeptidases, Endoribonucleases, Genetics, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, 030304 developmental biology, Organelles, chemistry.chemical_classification, 0303 health sciences, Messenger RNA, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Translation (biology), Cell biology, DNA-Binding Proteins, Decapping complex, Enzyme, chemistry, RNA splicing, Holoenzymes, 030217 neurology & neurosurgery, Protein Binding, Transcription Factors
Abstract: Most eukaryotic mRNAs harbor a characteristic 5′ m7GpppN cap that promotes pre-mRNA splicing, mRNA nucleocytoplasmic transport and translation while also protecting mRNAs from exonucleolytic attacks. mRNA caps are eliminated by Dcp2 during mRNA decay, allowing 5′-3′ exonucleases to degrade mRNA bodies. However, the Dcp2 decapping enzyme is poorly active on its own and requires binding to stable or transient protein partners to sever the cap of target mRNAs. Here, we analyse the role of one of these partners, the yeast Pby1 factor, which is known to co-localize into P-bodies together with decapping factors. We report that Pby1 uses its C-terminal domain to directly bind to the decapping enzyme. We solved the structure of this Pby1 domain alone and bound to the Dcp1–Dcp2–Edc3 decapping complex. Structure-based mutant analyses reveal that Pby1 binding to the decapping enzyme is required for its recruitment into P-bodies. Moreover, Pby1 binding to the decapping enzyme stimulates growth in conditions in which decapping activation is compromised. Our results point towards a direct connection of Pby1 with decapping and P-body formation, both stemming from its interaction with the Dcp1–Dcp2 holoenzyme.
Published: 2020

43. Design, synthesis, and biological evaluation of a multifunctional neuropeptide-Y conjugate for selective nuclear delivery of radiolanthanides

Author: Chastel, Adrien, Worm, Dennis, Alves, Isabel, Vimont, Delphine, Petrel, Melina, Fernandez, Samantha, Garrigue, Philippe, Fernandez, Philippe, Hindié, Elif, Beck-Sickinger, Annette, Morgat, Clément, Institut de Neurosciences cognitives et intégratives d'Aquitaine (INCIA), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-SFR Bordeaux Neurosciences-Centre National de la Recherche Scientifique (CNRS), Universität Leipzig [Leipzig], Chimie et Biologie des Membranes et des Nanoobjets (CBMN), École Nationale d'Ingénieurs des Travaux Agricoles - Bordeaux (ENITAB)-Institut de Chimie du CNRS (INC)-Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Bordeaux Imaging Center (BIC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut François Magendie-Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Centre Européen de Recherche en Imagerie médicale (CERIMED), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-École Centrale de Marseille (ECM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Centre National de la Recherche Scientifique (CNRS), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-SFR Bordeaux Neurosciences-Centre National de la Recherche Scientifique (CNRS), Universität Leipzig, Université de Bordeaux (UB)-École Nationale d'Ingénieurs des Travaux Agricoles - Bordeaux (ENITAB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Université de Bordeaux (UB)-Institut François Magendie-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Sub-cellular delivery, lcsh:Medical physics. Medical radiology. Nuclear medicine, Breast cancer, [SDV]Life Sciences [q-bio], lcsh:R895-920, 161Tb, Neuropeptide-Y, Auger-emitter, Tb-161, Original Research
Abstract: International audience; Background Targeting G protein-coupled receptors on the surface of cancer cells with peptide ligands is a promising concept for the selective tumor delivery of therapeutically active cargos, including radiometals for targeted radionuclide therapy (TRT). Recently, the radiolanthanide terbium-161 (Tb-161) gained significant interest for TRT application, since it decays with medium-energy beta-radiation but also emits a significant amount of conversion and Auger electrons with short tissue penetration range. The therapeutic efficiency of radiometals emitting Auger electrons, like Tb-161, can therefore be highly boosted by an additional subcellular delivery into the nucleus, in order to facilitate maximum dose deposition to the DNA. In this study, we describe the design of a multifunctional, radiolabeled neuropeptide-Y (NPY) conjugate, to address radiolanthanides to the nucleus of cells naturally overexpressing the human Y-1 receptor (hY(1)R). By using solid-phase peptide synthesis, the hY(1)R-preferring [F-7,P-34]-NPY was modified with a fatty acid, a cathepsin B-cleavable linker, followed by a nuclear localization sequence (NLS), and a DOTA chelator (compound pb12). In this proof-of-concept study, labeling was performed with either native terbium-159 (Tb-nat), as surrogate for Tb-161, or with indium-111 (In-111). Results [Tb-nat]Tb-pb12 showed a preserved high binding affinity to endogenous hY(1)R on MCF-7 cells and was able to induce receptor activation and internalization similar to the hY(1)R-preferring [F-7,P-34]-NPY. Specific internalization of the In-111-labeled conjugate into MCF-7 cells was observed, and importantly, time-dependent nuclear uptake of In-111 was demonstrated. Study of metabolic stability showed that the peptide is insufficiently stable in human plasma. This was confirmed by injection of [In-111]In-pb12 in nude mice bearing MCF-7 xenograft which showed specific uptake only at very early time point. Conclusion The multifunctional NPY conjugate with a releasable DOTA-NLS unit represents a promising concept for enhanced TRT with Auger electron-emitting radiolanthanides. Our research is now focusing on improving the reported concept with respect to the poor plasmatic stability of this promising radiopeptide.
Published: 2020

44. Defect Engineering Strategies Toward Controlled Functionalization of Solution-Processed Transition Metal Dichalcogenides

Author: Paolo Samorì, Stefano Ippolito, Institut de Science et d'ingénierie supramoléculaires (ISIS), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), ANR-10-LABX-0026,CSC,Center of Chemistry of Complex System(2010), ANR-11-LABX-0058,NIE,Nanostructures en Interaction avec leur Environnement(2011), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), European Project: 833707,SUPRA2DMAT, European Project: 881603,H2020,H2020-SGA-FET-GRAPHENE-2019, GrapheneCore3(2020), and univOAK, Archive ouverte
Subjects: [CHIM.MATE] Chemical Sciences/Material chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry
Abstract: International audience; Solution-processed transition metal dichalcogenides (TMDs) are attracting unceasing attention owing to their wide-ranging portfolio of physicochemical properties, making them prime candidates for low-cost and real-life applications in (opto)electronics, (bio)sensing, and energy-related technologies. The performance of TMD-based devices is strictly interconnected with the inherent features and quality of the materials, which should be tuned in view of their ultimate application. In this regard, the device performance is hitherto undermined by the presence of structural defects inherited from both the bulk systems and the exfoliation procedures. To overcome this limitation, a notable research effort has been devoted to the development of molecular strategies taking advantage of the defective nature of solution-processed TMDs, in order to meticulously tailor their physicochemical properties and expand the range of applicability. In this perspective, some of the most enlightening advances regarding the functionalization approaches exploiting TMD structural defects are presented, introducing the typical “imperfections” encountered in 2D crystal lattices (with different dimensionality, ranging from 0D to 2D) as well as discussing their in situ/ex situ generation methods. Finally, we highlight the future directions, challenges, and opportunities of defect engineering in TMDs by offering guidelines to boost the progress of 2D materials science and related technology.
Published: 2022

45. Hepatocellular carcinoma chemoprevention by targeting the angiotensin-converting enzyme and EGFR transactivation

Author: Emilie Crouchet, Shen Li, Mozhdeh Sojoodi, Simonetta Bandiera, Naoto Fujiwara, Hussein El Saghire, Shijia Zhu, Tongqi Qian, Fahmida Akter Rasha, Fabio Del Zompo, Stephen C. Barrett, Eugénie Schaeffer, Marine A. Oudot, Clara Ponsolles, Sarah C. Durand, Sarani Ghoshal, Gunisha Arora, Fabio Giannone, Raymond T. Chung, Nevena Slovic, Nicolaas Van Renne, Emanuele Felli, Patrick Pessaux, Joachim Lupberger, Nathalie Pochet, Catherine Schuster, Kenneth K. Tanabe, Yujin Hoshida, Bryan C. Fuchs, Thomas F. Baumert, Institut de Recherche sur les Maladies Virales et Hépatiques (IVH), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Harvard Medical School [Boston] (HMS), University of Texas Southwestern Medical Center [Dallas], Les Hôpitaux Universitaires de Strasbourg (HUS), L'Institut hospitalo-universitaire de Strasbourg (IHU Strasbourg), Institut National de Recherche en Informatique et en Automatique (Inria)-l'Institut de Recherche contre les Cancers de l'Appareil Digestif (IRCAD)-Les Hôpitaux Universitaires de Strasbourg (HUS)-La Fédération des Crédits Mutuels Centre Est (FCMCE)-L'Association pour la Recherche contre le Cancer (ARC)-La société Karl STORZ, Massachusetts General Hospital [Boston], Massachusetts Institute of Technology (MIT), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), ANR-17-EURE-0023,IMCBio,Integrative Molecular and Cellular Biology(2017), ANR-20-SFRI-0012,STRAT'US,Façonner les talents en formation et en recherche à l'Université de Strasbourg(2020), European Project: 667273,H2020,H2020-PHC-2015-two-stage,HEP-CAR(2016), European Project: 862551,HEPCAN, European Project: 101021417,FIBCAN, and European Project: 671231,H2020,ERC-2014-ADG,HEPCIR(2016)
Subjects: Liver Cirrhosis, Transcriptional Activation, Captopril, Carcinoma, Hepatocellular, Hepatology, Carcinogenesis, Liver Neoplasms, Angiotensin-Converting Enzyme Inhibitors, General Medicine, Sciences du Vivant [q-bio]/Médecine humaine et pathologie, Peptidyl-Dipeptidase A, Fibrosis, Chemoprevention, Rats, ErbB Receptors, Disease Progression, Animals, Liver cancer, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Hepatocellular carcinoma (HCC) is a leading cause of death among cirrhotic patients, for which chemopreventive strategies are lacking. Recently, we developed a simple human cell-based system modeling a clinical prognostic liver signature (PLS) predicting liver disease progression and HCC risk. In a previous study, we applied our cell-based system for drug discovery and identified captopril, an approved angiotensin converting enzyme (ACE) inhibitor, as a candidate compound for HCC chemoprevention. Here, we explored ACE as a therapeutic target for HCC chemoprevention. Captopril reduced liver fibrosis and effectively prevented liver disease progression toward HCC development in a diethylnitrosamine (DEN) rat cirrhosis model and a diet-based rat model for nonalcoholic steatohepatitis–induced (NASH-induced) hepatocarcinogenesis. RNA-Seq analysis of cirrhotic rat liver tissues uncovered that captopril suppressed the expression of pathways mediating fibrogenesis, inflammation, and carcinogenesis, including epidermal growth factor receptor (EGFR) signaling. Mechanistic data in liver disease models uncovered a cross-activation of the EGFR pathway by angiotensin. Corroborating the clinical translatability of the approach, captopril significantly reversed the HCC high-risk status of the PLS in liver tissues of patients with advanced fibrosis. Captopril effectively prevents fibrotic liver disease progression toward HCC development in preclinical models and is a generic and safe candidate drug for HCC chemoprevention.
Published: 2022

46. Retinoic Acid Receptor Alpha Is Essential in Postnatal Sertoli Cells but Not in Germ Cells

Author: Diana Condrea, Sirine Souali-Crespo, Betty Féret, Muriel Klopfenstein, Sylvain Faisan, Manuel Mark, Norbert B. Ghyselinck, Nadège Vernet, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), ANR-17-CE14-0010,CoRNuSperm,Corégulateurs des récepteurs nucléaires dans la spermatogenèse(2017), ANR-20-CE14-0022,ARDIGERM,Acide rétinoïque dans la différenciation des cellules germinales et la méiose(2020), ANR-10-LABX-0030,INRT,Integrative Biology : Nuclear dynamics- Regenerative medicine - Translational medicine(2010), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), GHYSELINCK, Norbert B., and Corégulateurs des récepteurs nucléaires dans la spermatogenèse - - CoRNuSperm2017 - ANR-17-CE14-0010 - AAPG2017 - VALID
Subjects: Male, [SDV.BDD.GAM] Life Sciences [q-bio]/Development Biology/Gametogenesis, endocrine system, tamoxifen-inducible Cre recombinase, Sertoli Cells, Retinoic Acid Receptor alpha, anti-RARA antibodies for IHC, mouse, retinoic acid, Sertoli cell, seminiferous epithelium, Sox9-CreERT2, spermatogenesis, Stra8-Cre, synchronization factor, testis, Tretinoin, General Medicine, Retinoic Acid Receptor, Spermatogonia, Animals, Sexual Maturation, [SDV.BDD.GAM]Life Sciences [q-bio]/Development Biology/Gametogenesis
Abstract: International audience; Retinoic acid signaling is indispensable for the completion of spermatogenesis. It is known that loss of retinoic acid nuclear receptor alpha (RARA) induces male sterility due to seminiferous epithelium degeneration. Initial genetic studies established that RARA acts in Sertoli cells, but a recent paper proposed that RARA is also instrumental in germ cells. In the present study, we have re-assessed the function of RARA in germ cells by genetically ablating the Rara gene in spermatogonia and their progenies using a cell-specific conditional mutagenesis approach. We show that loss of Rara in postnatal male germ cells does not alter the histology of the seminiferous epithelium. Furthermore, RARA-deficient germ cells differentiate normally and give rise to normal, living pups. This establishes that RARA plays no crucial role in germ cells. We also tested whether RARA is required in Sertoli cells during the fetal period or after birth. For this purpose, we deleted the Rara gene in Sertoli cells at postnatal day 15 (PN15), i.e., after the onset of the first spermatogenic wave. To do so, we used temporally controlled cell-specific mutagenesis. By comparing the testis phenotypes generated when Rara is lost either at PN15 or at embryonic day 13, we show that RARA exerts all of its functions in Sertoli cells not at the fetal stage but from puberty.
Published: 2022

47. PARP3 supervises G9a-mediated repression of adhesion and hypoxia-responsive genes in glioblastoma cells

Author: Leonel Nguekeu-Zebaze, Najat Hanini, Aurélia Noll, Nadège Wadier, Jean-Christophe Amé, Lisa Roegel, Françoise Dantzer, Biotechnologie et signalisation cellulaire (BSC), Université de Strasbourg (UNISTRA)-Institut de recherche de l'Ecole de biotechnologie de Strasbourg (IREBS)-Centre National de la Recherche Scientifique (CNRS), ANR-13-BSV6-0003,ARREPRESS,Bases moléculaires et impact physiologique de la répression des gènes par les récepteurs de l'acide rétinoïque(2013), ANR-13-BSV2-0017,ARGONADS,Acide rétinoique et devenir des cellules germinales(2013), ANR-10-LABX-0030,INRT,Integrative Biology : Nuclear dynamics- Regenerative medicine - Translational medicine(2010), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), ANR-10-INBS-0007,PHENOMIN,INFRASTRUCTURE NATIONALE EN PHENOGENOMIQUE SOURIS(2010), and European Project: 331687,EC:FP7:PEOPLE,FP7-PEOPLE-2012-IEF,INVIVO_RA_NONCANON(2013)
Subjects: Multidisciplinary, Brain Neoplasms, Lysine, Tumor Suppressor Proteins, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Cell Cycle Proteins, [SDV.CAN]Life Sciences [q-bio]/Cancer, Methyltransferases, Complement C9, Histones, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Basic Helix-Loop-Helix Transcription Factors, Humans, Poly(ADP-ribose) Polymerases, Glioblastoma, Hypoxia
Abstract: In breast cancer, Poly(ADP-ribose) polymerase 3 (PARP3) has been identified as a key driver of tumor aggressiveness exemplifying its selective inhibition as a promising surrogate for clinical activity onto difficult-to-treat cancers. Here we explored the role of PARP3 in the oncogenicity of glioblastoma, the most aggressive type of brain cancer. The absence of PARP3 did not alter cell proliferation nor the in vivo tumorigenic potential of glioblastoma cells. We identified a physical and functional interaction of PARP3 with the histone H3 lysine 9 methyltransferase G9a. We show that PARP3 helps to adjust G9a-dependent repression of the adhesion genes Nfasc and Parvb and the hypoxia-responsive genes Hif-2α, Runx3, Mlh1, Ndrg1, Ndrg2 and Ndrg4. Specifically for Nfasc, Parvb and Ndrg4, PARP3/G9a cooperate for an adjusted establishment of the repressive mark H3K9me2. While examining the functional consequence in cell response to hypoxia, we discovered that PARP3 acts to maintain the cytoskeletal microtubule stability. As a result, the absence of PARP3 markedly increases the sensitivity of glioblastoma cells to microtubule-destabilizing agents providing a new therapeutic avenue for PARP3 inhibition in brain cancer therapy.
Published: 2022

48. Deep-UV laser direct writing of photoluminescent ZnO submicron patterns: an example of nanoarchitectonics concept

Author: Quentin Kirscher, Samar Hajjar-Garreau, Fabien Grasset, Dominique Berling, Olivier Soppera, Institut de Science des Matériaux de Mulhouse (IS2M), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), National Institute for Materials Science (NIMS), Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratory for Innovative Key Materials and Structures (LINK), SAINT-GOBAIN-National Institute of Materials Science-Centre National de la Recherche Scientifique (CNRS), ANR-18-CE08-0022,DUVNANO,Fabrication de couches minces fonctionnelle en combinant les procédés de nanolithographie UV profonds et la chimie colloïdale des nanocristaux(2018), ANR-20-SFRI-0012,STRAT'US,Façonner les talents en formation et en recherche à l'Université de Strasbourg(2020), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), Jonchère, Laurent, APPEL À PROJETS GÉNÉRIQUE 2018 - Fabrication de couches minces fonctionnelle en combinant les procédés de nanolithographie UV profonds et la chimie colloïdale des nanocristaux - - DUVNANO2018 - ANR-18-CE08-0022 - AAPG2018 - VALID, Façonner les talents en formation et en recherche à l'Université de Strasbourg - - STRAT'US2020 - ANR-20-SFRI-0012 - SFRI - VALID, Initiative d'excellence - Par-delà les frontières, l'Université de Strasbourg - - UNISTRA2010 - ANR-10-IDEX-0002 - IDEX - VALID, and Saint-Gobain-National Institute of Materials Science-Centre National de la Recherche Scientifique (CNRS)
Subjects: Photolithography, [CHIM] Chemical Sciences, ZnO, [CHIM]Chemical Sciences, General Materials Science, Optical coatings, Photoluminescence, Nanoarchitectonics, Nanocrystals
Abstract: International audience; Micro- and nanopatterning of metal oxide materials is an important process to develop electronic or optoelectronic devices. ZnO is a material of choice for its semiconducting and photoluminescence properties. In the frame of the nanoarchitectonics concept, we have developed and investigated a new process that relies on direct writing laser patterning in the Deep-UV (DUV) range to prepare photoluminescent microstructures of ZnO at room temperature, under air. This process is based on a synthesis of colloidal ZnO nanocrystals (NCs) with a careful choice of the ligands on the surface to obtain an optimal (i) stability of the colloids, (ii) redissolution of the non-insolated parts and (iii) cross-linking of the DUV-insolated parts. The mechanisms of photocrosslinking are studied by different spectroscopic methods. This room temperature process preserves the photoluminescence properties of the NCs and the wavelength used in DUV allows to reach a sub-micrometer resolution, which opens new perspectives for the integration of microstructures on flexible substrates for optoelectronic applications.
Published: 2022
Full Text: View/download PDF

49. One-Step Generation of Alginate-Based Hydrogel Foams Using CO2 for Simultaneous Foaming and Gelation

Author: Imene Ben Djemaa, Sébastien Andrieux, Stéphane Auguste, Leandro Jacomine, Malgorzata Tarnowska, Wiebke Drenckhan-Andreatta, Drenckhan-Andreatta, Wiebke, Institut Charles Sadron (ICS), Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Laboratoires URGO - Recherche innovation et développement, Laboratoires URGO, URGO, CIFRE ANRT (agreement n°2019/1150), Interdisciplinary Institute HiFunMat, as part of the ITI 2021‐2028 programof the University of Strasbourg, CNRS, and Inserm, IdEx Unistra (ANR‐10‐IDEX‐0002) and SFRI (STRAT’US project, ANR‐20‐SFRI‐0012), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), ANR-20-SFRI-0012,STRAT'US,Façonner les talents en formation et en recherche à l'Université de Strasbourg(2020), and European Project: 819511,METAFOAM
Subjects: liquid foam templating, [CHIM.POLY] Chemical Sciences/Polymers, Polymers and Plastics, Organic Chemistry, Bioengineering, hydrogel foams liquid foam templating alginate hydrogels gas-initiated cross-linking interfacial rheology, [PHYS.PHYS.PHYS-CHEM-PH] Physics [physics]/Physics [physics]/Chemical Physics [physics.chem-ph], Biomaterials, gas-initiated cross-linking, [CHIM.POLY]Chemical Sciences/Polymers, interfacial rheology, [PHYS.PHYS.PHYS-CHEM-PH]Physics [physics]/Physics [physics]/Chemical Physics [physics.chem-ph], alginate hydrogels, hydrogel foams
Abstract: International audience; The reliable generation of hydrogel foams remains a challenge in a wide range of sectors, including food, cosmetic, agricultural, and medical applications. Using the example of calcium alginate foams, we introduce a novel foam generation method that uses CO2 for the simultaneous foaming and pH reduction of the alginate solution to trigger gelation. We show that gelled foams of different gas fractions can be generated in a simple one-step process. We macroscopically follow the acidification using a pH-responsive indicator and investigate the role of CO2 in foam ageing via foam stability measurements. Finally, we demonstrate the utility of interfacial rheology to provide evidence for the gelation process initiated by the dissolution of the CO2 from the dispersed phase. Both approaches, gas-initiated gelation and interfacial rheology for its characterization, can be readily transferred to other types of gases and formulations.
Published: 2022

50. MANGO: Low-Cost Open Source Needle Guidance

Author: Galvao da Mata, Joao Victor, Krumb, Henry, Mishra, Utkarsh, Mukhopadhay, Anirban, Essert, Caroline, Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Technische Universität Darmstadt - Technical University of Darmstadt (TU Darmstadt), Indian Institute of Technology [BHU Varanasi] (IIT BHU), ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), and ANR-20-SFRI-0012,STRAT'US,Façonner les talents en formation et en recherche à l'Université de Strasbourg(2020)
Subjects: Informatique [cs]/Traitement des images [eess.IV], [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV], Biomedical Engineering, Computational Mechanics, Radiology, Nuclear Medicine and imaging, Computer Science Applications
Published: 2022

Catalog

Books, media, physical & digital resources

See catalog results

Searchworks

Select search scope, currently: Articles Catalog books, media & more in Jio Institute collections Articles journal articles & other e-resources

Search

Search Constraints

Refine your results

Search Limiters

Topic

Publication Year Range

Language

Journal

Database

Publisher

207 results on '"ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010)"'

Search Results

Catalog

Select search scope, currently: Articles

Catalog

books, media & more in Jio Institute collections

Articles

journal articles & other e-resources