Search

Your search keyword '"ANASTROZOLE"' showing total 6,246 results
Start Over Descriptor "ANASTROZOLE"
6,246 results on '"ANASTROZOLE"'

22. ETHAN - ET for Male BC

Author

Eli Lilly and Company, Translational Breast Cancer Research Consortium (TBCRC), and Jose Pablo Leone, Principal Investigator

Published
2024

24. Pulmonary Hypertension and Anastrozole Trial (PHANTOM)

Author

National Heart, Lung, and Blood Institute (NHLBI), Johns Hopkins University, University of Colorado, Denver, Rhode Island Hospital, Stanford University, Vanderbilt University, and Washington University School of Medicine

Published
2024

25. Combination clomiphene citrate and anastrozole duotherapy improves semen parameters in a multi-institutional, retrospective cohort of infertile men.

Author

Osadchiy, Vadim, Munoz-Lopez, Carlos, Jiang, Tommy, Naelitz, Bryan, Parekh, Neel, Vij, Sarah, Mills, Jesse, Lundy, Scott, and Eleswarapu, Sriram

Subjects
Clomiphene, anastrozole, idiopathic infertility, semen analysis parameters (SA parameters), total motile sperm count (TMSC)
Abstract

In men with impaired semen parameters, empiric medical therapies such as clomiphene citrate, a selective estrogen receptor modulator (SERM), and anastrozole, a selective aromatase inhibitor, are often employed. The effects of jointly administering these agents on semen parameters are not well understood. Here, we describe the findings of our multi-center, retrospective cohort study of men with idiopathic primary or secondary infertility. Twenty-one men were treated with combination therapy (anastrozole and clomiphene) and 69 men were treated with monotherapy (anastrozole). Patients with pre-treatment normozoospermia and recent or current exogenous testosterone therapy were excluded. Baseline and post-treatment semen and sex hormone parameters were compared among groups. The median follow-up duration was 91 days [interquartile range (IQR), 64-117 days]. Following treatment, 43% of men in the combination therapy group demonstrated normozoospermia, compared to 25% in the monotherapy group. Furthermore, men in the combined group demonstrated marked improvements in total motile sperm count (TMSC) [11.3 vs. 2.1 million (M), P=0.03]. There were no significant differences in hormone levels among the two groups following treatment. Combination therapy with clomiphene citrate and anastrozole was associated with modest benefits in post-treatment semen parameters, when compared to anastrozole monotherapy. These benefits may contribute to improvements in pregnancy outcomes with less invasive assisted reproductive technologies, such as intrauterine insemination (IUI). Future investigations with larger sample sizes and prospective study designs are necessary.

Published
2024

46. Prediction of Treatment Efficacy of the Combination of Palbociclib/(Letrozole or Anastrozole) in First Line Metastatic Women With Luminal, HER2 Negative Advanced Breast Cancer, Using Infrared Laser Spectroscopy Analysis on Liquid Biopsies. (ICRG0201)

Author

King Saud University Medical City, Riyadh, Saudi Arabia, Max-Planck-Institut für Quantenoptik (MPQ), and Faculty of Physics at Ludwig-Maximilians-Universität München (LMU), Garching, Germany, and King Abdallah University for Science and Technology (KAUST), Thuwal, Saudi Arabia.

Published
2024

Catalog

Books, media, physical & digital resources
See catalog results