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7 results on '"AMADORE, D."'

1. Preterm birth: incidence, risk factors and second trimester cervical length in a single center population. A two-year retrospective study

Author

Granese, R., Mantegna, S., Stefania Mondello, Amadore, D., Imbesi, G., Calagna, G., Marci, R., Magro Malosso, E. R., Triolo, O., Granese, R, Mantegna, S, Mondello, S, Amadore, D, Imbesi, G, Calagna, G, Marci, R, Magro Malosso, E R, and Triolo, O

Subjects
Adult, Incidence, Cervical length, Preterm birth, Risk factors of preterm birth, Transvaginal ultrasound, Pharmacology (medical), Socio-culturale, Gestational Age, Cervix Uteri, Cohort Studies, Preterm birth, Risk factors of preterm birth, Cervical length, Transvaginal ultrasound, Italy, Cervical Length Measurement, Pregnancy, Risk Factors, Pregnancy Trimester, Second, Humans, Premature Birth, Female, Retrospective Studies, Ultrasonography
Abstract

To report the incidence and the major risk factors (RFs) associated with preterm birth (PTB), combining both maternal RFs and cervical length (CL), and to understand if cervical length measurement is really useful in all the patients.The study population consisted of 2048 women admitted to the Department of Obstetrics and Gynecology, University Hospital of Messina, over a 2-year period. Preterm cases represented approximately 8.64% of our total population and, exactly, 65% were late preterm, 32% were preterm, and 3% were extremely preterm.An analysis of PTB sub-categories based on gestational age showed a stronger correlation between gestational age and CL among preterm and extremely preterm, while no correlation was found among late preterm. Between preterm cases and controls, there was a significant difference in pre-pregnancy weight and Body Mass Index (BMI). Moreover, a significant association between PTB and uterine anomalies, poli-oligodramnios and hypertension was found.We strongly suggest adding a transvaginal ultrasound CL universal screening to all pregnant women at the time of the second trimester ultrasound. We encourage further studies to identify new RFs of PTB and to define the mechanisms by which risk factors are related to PTB.

Published
2017

3. Preterm birth: seven-year retrospective study in a single centre population

Author

Ilaria Fazzolari, Eloisa Gitto, Gloria Calagna, Giovanni Corsello, Donatella Amadore, Raffaele Falsaperla, Roberta Granese, Roberta Grasso, Onofrio Triolo, Gabriella D'Angelo, and Granese R, Gitto E, D'Angelo G, Falsaperla R, Corsello G, Amadore D, Calagna G, Fazzolari I, Grasso R, Triolo O

Subjects
Adult, medicine.medical_specialty, Population, Oligohydramnios, Trans-vaginal cervical screening, Single Center, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Thinness, Obstetrics and gynaecology, Pregnancy, 030225 pediatrics, medicine, Humans, Obesity, 030212 general & internal medicine, education, Retrospective Studies, Birth, Cervical length, Prematurity, Risk factors, Trans-vaginal cervical screening, Pediatrics, Perinatology and Child Health, education.field_of_study, Marital Status, business.industry, Obstetrics, Research, Incidence (epidemiology), Infant, Newborn, lcsh:RJ1-570, Retrospective cohort study, lcsh:Pediatrics, General Medicine, medicine.disease, Pregnancy Complications, Italy, Risk factors, Cervical Length Measurement, Cohort, Premature Birth, Female, Risk factor, Underweight, medicine.symptom, business, Prematurity, Cervical length
Abstract

Preterm birth is a health and social problem, considered the leading cause of neonatal mortality worldwide. It is associated with higher rates of neurodevelopmental morbidity, sensorineural impairments and other complications. The aim of the study was to describe the incidence and the major risk factors associated with preterm birth. METHODS: We performed a single center, observational and retrospective Cohort study in the Division of Obstetrics and Gynaecology, University Hospital "G. Martino", Messina. Clinical records of all pregnant women who delivered from 1st January 2010 to 31 of December 2016 were collected. RESULTS: In the 7 years considered, a total of 7954 pregnant women were included in our study. The majority of all preterm births were due to infants born late preterm (71.83%), 26.45% were due to preterm and 1.72% to extremely preterm. The preterm cohort had a higher proportion of history of preterm delivery (p

Published
2019

4. Hysteroscopic Evaluation of Endometrial Changes in Breast Cancer Women with or without Hormone Therapies: Results from a Large Multicenter Cohort Study

Author

Enrico Vizza, Silvia Di Angelo Antonio, Onofrio Triolo, Alessandro Favilli, Gloria Calagna, Gaspare Cucinella, Vittorio Palmara, Ivano Mazzon, Roberta Granese, Donatella Amadore, Salvatore Giovanni Vitale, Giuseppe Vocaturo, Marianna Maranto, Benito Chiofalo, Antonio Simone Laganà, Fabio Ghezzi, Isabella Sperduti, Chiofalo B., Mazzon I., Di Angelo Antonio S., Amadore D., Vizza E., Lagana A.S., Vocaturo G., Calagna G., Favilli A., Palmara V., Maranto M., Vitale S.G., Cucinella G., Granese R., Ghezzi F., Sperduti I., and Triolo O.

Subjects
Biopsy, Aromatase inhibitors, Breast cancer, Endometrial cancer, Endometrial pathologies, Tamoxifen, Adult, Aged, Aged, 80 and over, Antineoplastic Agents, Hormonal, Biopsy, Breast Neoplasms, Cohort Studies, Endometrial Hyperplasia, Endometrial Neoplasms, Endometrium, Female, Humans, Hysteroscopy, Incidence, Middle Aged, Polyps, Precancerous Conditions, Pregnancy, Retrospective Studies, Tamoxifen, Uterine Diseases, Uterine Neoplasms, Cohort Studies, Endometrium, 0302 clinical medicine, Breast cancer, Endometrial cancer, Pregnancy, Aromatase inhibitors, Endometrial pathologies, Tamoxifen, Aged, 80 and over, Uterine Diseases, 030219 obstetrics & reproductive medicine, medicine.diagnostic_test, Incidence, Obstetrics and Gynecology, Middle Aged, Hysteroscopy, 030220 oncology & carcinogenesis, Endometrial Hyperplasia, Uterine Neoplasms, Female, medicine.drug, Aromatase inhibitors, Breast cancer, Endometrial cancer, Endometrial pathologies, Tamoxifen, Adult, medicine.medical_specialty, Antineoplastic Agents, Hormonal, Breast Neoplasms, 03 medical and health sciences, Polyps, medicine, Endometrial Polyp, Humans, Aged, Retrospective Studies, Gynecology, business.industry, Cancer, Retrospective cohort study, medicine.disease, Endometrial Neoplasms, business, Precancerous Conditions, Endometrial biopsy
Abstract

Study Objective The primary aim of our study was to investigate the incidence of endometrial pathologies, especially endometrial cancer, in women with breast cancer treated with tamoxifen (TAM), aromatase inhibitors (AIs), or receiving no treatment (NT). The secondary aim was to identify, in this cohort, ultrasonographic findings that represent robust indications for hysteroscopy and endometrial biopsy, to avoid unnecessary second-level diagnostic procedures. Design Multicenter retrospective cohort study (Clinical Trial ID: NCT03898947). Setting Data were collected from different Italian centers: Regina Elena National Cancer Institute of Rome, Arbor Vitae Centre of Rome, Gaetano Martino University Hospital of Messina, and Villa Sofia-Cervello Hospital of Palermo. Patients We selected and consecutively included patients with a history of breast cancer who had undergone hysteroscopy for ultrasonographic or clinical indications between January 2007 and December 2016. Interventions Diagnostic hysteroscopy with endometrial biopsy or operative hysteroscopy, when clinically indicated. Measurements and Main Results A higher percentage of patients in the TAM and AI groups had a normal endometrium compared with those in the NT group, whereas the incidence of endometrial polyps was higher in the NT group than in the others; no significant differences were observed among the 3 groups for other benign conditions or for premalignant and malignant uterine diseases, such as endometrial atypical hyperplasia and adenocarcinoma. Conclusion TAM treatment does not seem to be associated with a higher rate of endometrial cancer in women with breast cancer compared with women treated with AIs or NT.

Published
2020

5. Hysteroscopic Evaluation of Endometrial Changes in Breast Cancer Women with or without Hormone Therapies: Results from a Large Multicenter Cohort Study.

Author

Chiofalo B, Mazzon I, Di Angelo Antonio S, Amadore D, Vizza E, Laganà AS, Vocaturo G, Calagna G, Favilli A, Palmara V, Maranto M, Vitale SG, Cucinella G, Granese R, Ghezzi F, Sperduti I, and Triolo O

Subjects
Adult, Aged, Aged, 80 and over, Biopsy, Breast Neoplasms drug therapy, Breast Neoplasms epidemiology, Breast Neoplasms pathology, Cohort Studies, Endometrial Hyperplasia diagnosis, Endometrial Hyperplasia epidemiology, Endometrial Hyperplasia pathology, Endometrial Neoplasms diagnosis, Endometrial Neoplasms epidemiology, Endometrial Neoplasms pathology, Endometrium pathology, Female, Humans, Hysteroscopy methods, Hysteroscopy statistics & numerical data, Incidence, Middle Aged, Polyps diagnosis, Polyps epidemiology, Polyps pathology, Precancerous Conditions diagnosis, Precancerous Conditions epidemiology, Precancerous Conditions pathology, Pregnancy, Retrospective Studies, Tamoxifen therapeutic use, Uterine Diseases pathology, Uterine Neoplasms diagnosis, Uterine Neoplasms epidemiology, Uterine Neoplasms pathology, Antineoplastic Agents, Hormonal therapeutic use, Breast Neoplasms diagnostic imaging, Endometrium diagnostic imaging, Uterine Diseases diagnosis, Uterine Diseases epidemiology
Abstract

Study Objective: The primary aim of our study was to investigate the incidence of endometrial pathologies, especially endometrial cancer, in women with breast cancer treated with tamoxifen (TAM), aromatase inhibitors (AIs), or receiving no treatment (NT). The secondary aim was to identify, in this cohort, ultrasonographic findings that represent robust indications for hysteroscopy and endometrial biopsy, to avoid unnecessary second-level diagnostic procedures., Design: Multicenter retrospective cohort study (Clinical Trial ID: NCT03898947)., Setting: Data were collected from different Italian centers: Regina Elena National Cancer Institute of Rome, Arbor Vitae Centre of Rome, Gaetano Martino University Hospital of Messina, and Villa Sofia-Cervello Hospital of Palermo., Patients: We selected and consecutively included patients with a history of breast cancer who had undergone hysteroscopy for ultrasonographic or clinical indications between January 2007 and December 2016., Interventions: Diagnostic hysteroscopy with endometrial biopsy or operative hysteroscopy, when clinically indicated., Measurements and Main Results: A higher percentage of patients in the TAM and AI groups had a normal endometrium compared with those in the NT group, whereas the incidence of endometrial polyps was higher in the NT group than in the others; no significant differences were observed among the 3 groups for other benign conditions or for premalignant and malignant uterine diseases, such as endometrial atypical hyperplasia and adenocarcinoma., Conclusion: TAM treatment does not seem to be associated with a higher rate of endometrial cancer in women with breast cancer compared with women treated with AIs or NT., (Copyright © 2019 AAGL. Published by Elsevier Inc. All rights reserved.)

Published
2020
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6. Preterm birth: seven-year retrospective study in a single centre population.

Author

Granese R, Gitto E, D'Angelo G, Falsaperla R, Corsello G, Amadore D, Calagna G, Fazzolari I, Grasso R, and Triolo O

Subjects
Adult, Cervical Length Measurement, Cohort Studies, Female, Humans, Infant, Newborn, Italy epidemiology, Marital Status, Obesity epidemiology, Pregnancy, Pregnancy Complications epidemiology, Retrospective Studies, Risk Factors, Thinness epidemiology, Premature Birth epidemiology
Abstract

Background: Preterm birth is a health and social problem, considered the leading cause of neonatal mortality worldwide. It is associated with higher rates of neurodevelopmental morbidity, sensorineural impairments and other complications. The aim of the study was to describe the incidence and the major risk factors associated with preterm birth., Methods: We performed a single center, observational and retrospective Cohort study in the Division of Obstetrics and Gynaecology, University Hospital "G. Martino", Messina. Clinical records of all pregnant women who delivered from 1st January 2010 to 31 of December 2016 were collected., Results: In the 7 years considered, a total of 7954 pregnant women were included in our study. The majority of all preterm births were due to infants born late preterm (71.83%), 26.45% were due to preterm and 1.72% to extremely preterm. The preterm cohort had a higher proportion of history of preterm delivery (p < 0.0001), and unmarried (p = 0.003) and underweight or obese patients (p < 0.0001). In addition, prematurity was associated with presence of uterine anomalies (p < 0.0001), vaginal/urinary infections (p = 0.02), poli/oligohydramnios (p < 0.0001), maternal diabetes (p = 0.004), hypertension (p < 0.0001), short cervical length (p < 0.0001)., Conclusions: We suggest prompt identification of all risk factors associated with preterm birth to apply immediate and appropriate specific interventions.

Published
2019
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7. Preterm birth: incidence, risk factors and second trimester cervical length in a single center population. A two-year retrospective study.

Author

Granese R, Mantegna S, Mondello S, Amadore D, Imbesi G, Calagna G, Marci R, Magro Malosso ER, and Triolo O

Subjects
Adult, Cervix Uteri, Cohort Studies, Female, Gestational Age, Humans, Incidence, Italy, Pregnancy, Pregnancy Trimester, Second, Retrospective Studies, Risk Factors, Ultrasonography, Cervical Length Measurement, Premature Birth diagnostic imaging, Premature Birth epidemiology
Abstract

Objective: To report the incidence and the major risk factors (RFs) associated with preterm birth (PTB), combining both maternal RFs and cervical length (CL), and to understand if cervical length measurement is really useful in all the patients., Patients and Methods: The study population consisted of 2048 women admitted to the Department of Obstetrics and Gynecology, University Hospital of Messina, over a 2-year period. Preterm cases represented approximately 8.64% of our total population and, exactly, 65% were late preterm, 32% were preterm, and 3% were extremely preterm., Results: An analysis of PTB sub-categories based on gestational age showed a stronger correlation between gestational age and CL among preterm and extremely preterm, while no correlation was found among late preterm. Between preterm cases and controls, there was a significant difference in pre-pregnancy weight and Body Mass Index (BMI). Moreover, a significant association between PTB and uterine anomalies, poli-oligodramnios and hypertension was found., Conclusions: We strongly suggest adding a transvaginal ultrasound CL universal screening to all pregnant women at the time of the second trimester ultrasound. We encourage further studies to identify new RFs of PTB and to define the mechanisms by which risk factors are related to PTB.

Published
2017

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