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Previous studies indicated colorectal cancer (CRC) is the third leading cause of cancer in the world and the second in terms of mortality, CRC is spread between men and women, CRC spreads in different location of the colon and rectum, . Colorectal cancer affects in different age and the number of CRC patient has increased in the past two decades, especially within the younger age. Molecular studies indicated, many changes in genetic, epigenetic and gene expression in many genes contributed to the emergence and development of colorectal cancer. This study aimed to measure the gene expression for CYP24A1 and AHR genes in iraqi patients with CRC, and study age groups and locations of CRC within the colon and rectum. The results showed an overexpression of CYP24A1 gene (6.1) fold change and AHR expression had(1.8) fold change,and males are more likely to develop colon rectal cancer than women's, and most patient colorectal cancer ranged between 45 to 68 years old . [ABSTRACT FROM AUTHOR]

Colorectal cancer (CRC) is one of the most common malignancies of the digestive system worldwide with the incidence has being increased significantly over the past three decades. CRC could present as sporadic (70%), more than half (55%) of all CRCs are attributable to lifestyle factors, including an unhealthy diet. Some studies refer higher circulating vitamin D ( 25(OH)D )was related to a statistically significant, substantially lower colorectal cancer risk, and other studies proposed the total calcium intake was inversely associated with the risk of developing colorectal cancer and other studies showed high total oxidant status ( TOS) are involved in the occurrence and development of malignant tumors. This study aims to investigate the change in the levels of calcium, vitamin D and total oxidant status levels in colorectal Patients. The results showed significance increased in total oxidant status in colorectal cancer patients but not for benign tumor and healthy peoples. Calcium levels were within the ideal limits for all groups and had not relationship with colorectal cancer. While vitamin D levels were below the normal level for all groups and Vitamin D levels was lower in the colorectal cancer group. Found inverse relationship between vitamin D levels and total oxidant status. [ABSTRACT FROM AUTHOR]