Search

This paper deals with a problem of tactical planning of production activities. It considers the case of the world's largest phosphate production site, with several mines, several washing plants, and a drying plant, with transport of merchantable phosphate ores (MOs) by rail or pipeline. The tightening of product quality requirements by customers prevents from continuing to plan its production with the current rules. Currently, the plants are managed quite independently, source ores (SOs) are pre-assigned to the MOs for blending, and the MO production routings in the washing plants are predetermined. We propose a model that ensures flexibility in the production of MOs through the choice of dynamic blends and routings. Our approach goes beyond any pre-allocation of resources and aims at synchronising the flows of the washing plants. This specific problem of blending production and planning has not been addressed in the literature. Still, it is widely encountered in many mining industries and offers perspectives for the application of the approach proposed. Numerous tests show that this model ensures the quality constraints related to the composition of several chemical components, with a generalised use of the most economical routings while ensuring horizontal and vertical alignment of decisions. [ABSTRACT FROM AUTHOR]

Liquid chromatography-high-resolution mass spectrometry (LC-HRMS), as applied to untargeted metabolomics, enables the simultaneous detection of thousands of small molecules, generating complex datasets. Alignment is a crucial step in data processing pipelines, whereby LC-MS features derived from common ions are assembled into a unified matrix amenable to further analysis. Variability in the analytical factors that influence liquid chromatography separations complicates data alignment. This is prominent when aligning data acquired in different laboratories, generated using non-identical instruments, or between batches from large-scale studies. Previously, we developed metabCombiner for aligning disparately acquired LC-MS metabolomics datasets. Here, we report significant upgrades to metabCombiner that enable the stepwise alignment of multiple untargeted LC-MS metabolomics datasets, facilitating inter-laboratory reproducibility studies. To accomplish this, a "primary" feature list is used as a template for matching compounds in "target" feature lists. We demonstrate this workflow by aligning four lipidomics datasets from core laboratories generated using each institution's in-house LC-MS instrumentation and methods. We also introduce batchCombine, an application of the metabCombiner framework for aligning experiments composed of multiple batches. metabCombiner is available as an R package on Github and Bioconductor, along with a new online version implemented as an R Shiny App.

Over the past few decades, instrumentation and techniques for total knee arthroplasty have evolved from conventional manual tools to a wide range of technologies, including calibrated guides for accurate bone cuts and alignment, smart tools, dynamic intraoperative sensors for soft tissue balancing, patient-specific guides, computer navigation, and robotics. This review is intended to provide an overview of the latest advancements in total knee arthroplasty technology, address potential challenges and solutions related to the application of these technologies, and explore their limitations. [ABSTRACT FROM AUTHOR]

Both participation and argumentation (OECD, 2022) are important keywords in educational contexts. While participation is seen as a crucial prerequisite for education and collaborative learning in general, argumentation as a discursive practice serves to convey and negotiate—also school-specific—knowledge. This paper explores repetition in argumentative events as a technique of establishing—or even hindering—participation in terms of alignment and affiliation. It can serve as a strategy for participation by signalling responsiveness and thematic coherence—and thus inclusion. At the same time, however, studies show that repetition can also signal contradiction and rejection—and thus exclusion. So far, we know little about how exactly these functional differences are produced—especially in younger children. Therefore, the paper explores how children use repetition as a resource for negotiating participation in argumentative events. Using authentic data in the form of observations and transcriptions of audio and video recordings from child-child-interactions of 15 Hebrew- and 31 German-speaking children aged 3–6 years, we identify oral argumentative events and investigate different forms of repetitions and their respective relevance for enabling participation. Our results show that, on the one hand, minimal and partial repetitions are used by the children in an inclusive way, creating closeness between the participants. On the other hand, children use complete repetitions more as an excluding technique, displaying misalignment and disaffiliation, in order to challenge and mock each other. The findings suggest that this line of research has significant potential to provide new insights into the formation of social relationships between peers, into the prevention or establishment of participation, which itself is a prerequisite for joint learning, as well as insights into the acquisition of argumentative competence. [ABSTRACT FROM AUTHOR]

In recent years, Conversational Analysis (CA) has seen an increasing interest in longitudinal studies (Deppermann & Pekarek Doehler, 2021). The recurrent experience of interactional practices leads interactants to develop routines that may sediment into entrenched patterns over time (Dreyer, 2022). Longitudinal CA thus aims to track the emergence and sedimentation of interactional practices over time. In this contribution, we analyse interactional practices of participation in play-situations. Participation in joint activities is a universal form of human sociality (Goodwin & Goodwin, 2005). Here, we focus on how children perform their own agentive participant's work and how mothers support their children in doing so. Investigating a longitudinal data set of mother-child play-interactions at ages 1 and 5, we ask whether participation patterns emerge as early as in the first year and are sedimented in the fifth year, as well as whether the synchronisation of embodied action provides crucial resources for the achievement of active participation in joint activities. [ABSTRACT FROM AUTHOR]

Purpose: To investigate the risk factors for varus progression after arthroscopic medial meniscal posterior root tear (MMPRT) repair and to compare the clinical outcomes between two groups: one with more varus progression and the other with less varus progression. Methods: Patients who underwent isolated arthroscopic repair of MMPRT between 2015 and 2020 were enroled, and 2‐year follow‐up data were collected. Participants were categorized into two groups based on preoperative values of the weight‐bearing line (WBL) ratio: group A with <5.9% increase and group B with ≥5.9% increase. Various factors, including demographic features and radiological findings, were analysed and compared between the two groups. Intra‐meniscal signal intensity, meniscal healing, medial meniscal extrusion (MME), and articular cartilage grade were assessed preoperatively and 1‐year postoperatively using coronal magnetic resonance imaging. Results: The final cohort consisted of 34 patients in group A and 46 in group B, with a mean age of 55.8 ± 11.2 and 59.8 ± 6.6 years, respectively. Preoperative WBL ratio and cartilage lesions in the medial compartment did not differ between the groups. Preoperative MME were significantly lower in group A than those in group B (2.6 ± 0.6 mm in group A and 3.5 ± 0.7 mm in group B, p < 0.05). Patient‐reported outcomes at the 2‐year follow‐up did not differ between the two groups (n. s.). In a logistic analysis, the odds ratio of MME was 2.1 (p < 0.05), and the cutoff value of MME was 3.02 mm. Conclusion: Preoperative MME is a risk factor for varus progression. However, no differences in patient‐reported outcomes were observed at 2‐year follow‐up, even in the group with greater varus progression. Level of Evidence: Level IV. [ABSTRACT FROM AUTHOR]

This paper examines the importance of, and variations in, political alignment within African regimes. Political alignment is how leaders establish sufficient political support across elites: we posit that formal appointments are the primary way that leaders manipulate political coalitions in order to secure their collective authority and tenure. Appointments, individually and collectively, can take on multiple characteristics: they can create inclusive or exclusive coalitions, transactional or loyal support, volatile or stable elite networks. Appointment powers have greater salience since governments institutionalized and formalized in governance systems across democratic and autocratic states. Manipulating who holds and secures power at the subnational and national levels, rather than repressive control or state capacity, underpins the stability, security, and survival of modern African regimes. [ABSTRACT FROM AUTHOR]

In recent years, the involvement of the compensation ability of the subtalar joint in lower extremity alignment has been reported. We previously showed that hindfoot alignment angle (HAA) is an indicator of compensation ability of the subtalar joint. The abnormal compensation ability of the subtalar joint was defined by the mobility of the subtalar joint, and evaluation of the mobility of the subtalar joint may help to further clarify the pathophysiology of abnormal compensation ability of the subtalar joint. This study was performed to evaluate the mobility of the subtalar joint and clarify the pathophysiology of abnormal compensation ability of the subtalar joint in the varus knee. Seventy-two knees of 72 patients aged ≥40 years with varus knee were included in this study. Preoperative radiographs were used for measurement of this study parameters. Based on our previous study, we defined HAA of ≥15.9°as abnormal compensation ability of the subtalar joint. The patients were divided into an abnormal group (A-group) and normal group (N-group). All measurement parameters were compared between the groups, and correlations between the HAA and each measurement parameter were analyzed. The weight-bearing hindfoot angle (WBHA) (p < 0.001) and non-weight-bearing hindfoot angle (non-WBHA) (p = 0.003), were significantly greater in the A-group than in the N-group. Conversely, the ratio of change in hindfoot alignment (p = 0.006), were significantly smaller in the A-group than in the N-group. The HAA was positively correlated with WBHA (r = 0.66) and non-WBHA (r = 0.43) and negatively correlated with the ratio of change in hindfoot alignment (r = −0.32). The pathophysiology of abnormal compensation ability of the subtalar joint in the varus knee is thought to involve a state of increased valgus of hindfoot alignment and an inability to move into normal hindfoot alignment. Level Ⅲ, retrospective study. [ABSTRACT FROM AUTHOR]

Machine learning (ML) applications in medical artificial intelligence (AI) systems have shifted from traditional and statistical methods to increasing application of deep learning models. This survey navigates the current landscape of multimodal ML, focusing on its profound impact on medical image analysis and clinical decision support systems. Emphasizing challenges and innovations in addressing multimodal representation, fusion, translation, alignment, and co-learning, the paper explores the transformative potential of multimodal models for clinical predictions. It also highlights the need for principled assessments and practical implementation of such models, bringing attention to the dynamics between decision support systems and healthcare providers and personnel. Despite advancements, challenges such as data biases and the scarcity of "big data" in many biomedical domains persist. We conclude with a discussion on principled innovation and collaborative efforts to further the mission of seamless integration of multimodal ML models into biomedical practice. [ABSTRACT FROM AUTHOR]

Copyright of Zeitschrift für Angewandte Linguistik is the property of De Gruyter and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

AbstractA rank test for Latin square data is derived. Forms are given for when there are no ties, for when ties occur and mid-ranks are used, and for when ties occur in general. These adjustments are akin to those for the Kruskal-Wallis, Friedman, and Durbin tests. Since substantial block effects may affect ranking, alignment is recommended. The ANOVA F test on the ranks, the rank transform test, is a competitor test. We designate this test, where the data are aligned before ranking, the FART test. The proposed test, implemented as a permutation test, is designated the permutation aligned RL test: the PARL. We also give an approximation to the sampling distribution using the χ2 distribution, and call this test the CARL. An indicative simulation study assuming the usual parametric model and testing the null hypothesis that the treatment parameter is zero shows that the CARL, PARL, FART, and the F test on the raw data all control their type I errors well and have comparable powers. [ABSTRACT FROM AUTHOR]

A three‐dimensional (3D) microstructural volume is reconstructed from a stack of two‐dimensional sections which was obtained by serial sectioning coupled with electron back scattering diffraction (EBSD) mapping of a 316L austenitic stainless steel. A new alignment algorithm named linear translation by minimising the indicator (LTMI) is proposed to reduce the translational misalignments between adjacent sections by referencing to coherent twin boundaries which are flat and lying on {111} planes. The angular difference between the measured orientation of a flat twin boundary and that of the {111} plane is used as an indicator of the accuracy of the alignment operations. This indicator is minimised through linear translations of the centroids of triangular facets, which constitute grain boundaries at a distance not restricted by the in‐plane step size of the EBSD maps. And hence the systematic trend in the translational misalignments can be effectively reduced. The LTMI alignment procedure proposed herein effectively corrects the misalignments remained by other methods on a 3D‐EBSD data prepared using serial sectioning methods. The accuracy in distinguishing between coherent and incoherent twin boundaries is significantly improved. [ABSTRACT FROM AUTHOR]

Individuals with neuromuscular pathologies are often prescribed an ankle-foot orthosis (AFO) to improve their gait mechanics by decreasing pathological movements of the ankle and lower limb. AFOs can resist or assist excessive or absent muscular forces that lead to tripping, instability, and slow inefficient gait. However, selecting the appropriate AFO with mechanical characteristics, which limit pathological ankle motion in certain phases of the gait cycle while facilitating effective ankle movement during other phases, requires careful clinical decision-making. The aim of this study is to propose an explicit methodology for the adjustment of multi-function articulated AFOs in clinical settings. A secondary aim is to outline the evidence supporting this methodology and to identify gaps in the literature as potential areas for future research. An emerging class of AFO, the multi-function articulated AFO, offers features that permit more comprehensive, iterative, and reversible adjustments of AFO ankle alignment and resistance to ankle motion. However, no standard method exists for the application and optimization of these therapeutic devices in the clinical setting. Here we propose an evidence-guided methodology applicable to the adjustment of multi-function articulated AFOs in the clinical setting. Characteristic load-deflection curves are given to illustrate the idealized yet complex resistance-angle behavior of multi-function articulated AFOs. Research is cited to demonstrate how these mechanical characteristics can help mitigate specific pathologic ankle and knee kinematics and kinetics. Evidence is presented to support the effects of systematic adjustment of high resistance, alignable, articulated AFOs to address many typical pathomechanical patterns observed in individuals with neuromuscular disorders. The published evidence supporting most decision points of the algorithm is presented with identified gaps in the evidence. In addition, two hypothetical case examples are given to illustrate the application of the method in optimizing multi-function articulated AFOs for treating specific gait pathomechanics. This method is proposed as an evidence-guided systematic approach for the adjustment of multi-function articulated AFOs. It utilizes observed gait deviations mapped to specific changes in AFO alignment and resistance settings as a clinical tool in orthotic treatment for individuals with complex neuromuscular gait disorders. [ABSTRACT FROM AUTHOR]

The rapid development of active safety systems in the automotive industry and research in autonomous driving requires reliable, high-precision sensors that provide rich information about the surrounding environment and the behaviour of other road users. In practice, there is always some non-zero mounting misalignment, i.e., angular inaccuracy in a sensor's mounting on a vehicle. It is essential to accurately estimate and compensate for this misalignment further programmatically (in software). In the case of radars, imprecise mounting may result in incorrect/inaccurate target information, problems with the tracking algorithm, or a decrease in the power reflected from the target. Sensor misalignment should be mitigated in two ways: through the correction of an inaccurate alignment angle via the estimated value of the misalignment angle or alerting other components of the system of potential sensor degradation if the misalignment is beyond the operational range. This work analyses misalignment's influences on radar sensors and other system components. In the mathematically proven example of a vertically misaligned radar, pedestrian detectability dropped to one-third of the maximum range. In addition, mathematically derived heading estimation errors demonstrate the impact on data association in data fusion. The simulation results presented show that the angle of misalignment exponentially increases the risk of false track splitting. Additionally, the paper presents a comprehensive review of radar alignment techniques, mostly found in the patent literature, and implements a baseline algorithm, along with suggested key performance indicators (KPIs) to facilitate comparisons for other researchers. [ABSTRACT FROM AUTHOR]

Degenerative diseases of the lumbar spine decrease lumbar lordosis (LL). Anterior lumbar interbody fusion (ALIF) at the L5-S1 disc space improves segmental lordosis, LL, and sagittal balance. This study investigated reciprocal changes in spinopelvic alignment after L5-S1 ALIF. A retrospective chart review identified patients who underwent L5-S1 ALIF with or without posterior fixation at a single institution (November 1, 2016 to October 1, 2021). Changes in pelvic tilt, sacral slope, proximal LL (L1-L4), distal LL (L4-S1), total LL (L1-S1), segmental lordosis, pelvic incidence–LL mismatch, thoracic kyphosis, cervical lordosis, and sagittal vertical axis were measured on preoperative and postoperative radiographs. Forty-eight patients were identified. Immediate postoperative radiographs were obtained at a mean (SD) of 17 (20) days after surgery; delayed radiographs were obtained 184 (82) days after surgery. After surgery, patients had significantly decreased pelvic tilt (15.71° [7.25°] vs. 17.52° [7.67°], P = 0.003) and proximal LL (11.86° [10.67°] vs. 16.03° [10.45°], P < 0.001) and increased sacral slope (39.49° [9.27°] vs. 36.31° [10.39°], P < 0.001), LL (55.35° [13.15°] vs. 51.63° [13.38°], P = 0.001), and distal LL (43.17° [9.33°] vs. 35.80° [8.02°], P < 0.001). Segmental lordosis increased significantly at L5-S1 and decreased significantly at L2-3, L3-4, and L4-5. Lordosis distribution index increased from 72.55 (19.53) to 81.38 (22.83) (P < 0.001). L5-S1 ALIF was associated with increased L5-S1 segmental lordosis accompanied by pelvic anteversion and a reciprocal decrease in proximal LL. These changes may represent a reversal of compensatory mechanisms, suggesting an overall relaxation of spinopelvic alignment after L5-S1 ALIF. [ABSTRACT FROM AUTHOR]

Timing is an important interactional resource for coordinating mobile and digital interactions, and for signalling interest and involvement in an exchange. This article breaks new ground in exploring conversational rhythm as a 'disconnective' resource through which people suspend, or withdraw from, interactions as a way of asserting agency and autonomy. Focusing on mobile-messaging apps such as WhatsApp, it develops an innovative 'day-in-the-life' methodological approach for exploring how individuals manage multiple online and offline encounters through combining interviews, time-use diaries and messaging data. Interactional analysis of selected extracts involving British women in their 40s and 50s points to an emerging interactive practice of 'suspended alignment' which enables connection-building through alignment while simultaneously keeping interlocutors at a desired distance. Suspended alignment is an increasingly accepted pragmatic norm through which adults maintain key relationships while managing the multiple demands on their time. • Day-in-the-life approach enables insights into how people manage parallel online/offline encounters. • Desire to connect through mobile messaging while maintaining autonomy prompts practice of suspended alignment. • Suspended alignment involves harnessing conversational rhythm to suspend mobile conversations. [ABSTRACT FROM AUTHOR]

Medical image registration has become pivotal in recent years with the integration of various imaging modalities like X-ray, ultrasound, MRI, and CT scans, enabling comprehensive analysis and diagnosis of biological structures. This paper provides a comprehensive review of registration techniques for medical images, with an in-depth focus on 2D-2D image registration methods. While 3D registration is briefly touched upon, the primary emphasis remains on 2D techniques and their applications. This review covers registration techniques for diverse modalities, including unimodal, multimodal, interpatient, and intra-patient. The paper explores the challenges encountered in medical image registration, including geometric distortion, differences in image properties, outliers, and optimization convergence, and discusses their impact on registration accuracy and reliability. Strategies for addressing these challenges are highlighted, emphasizing the need for continual innovation and refinement of techniques to enhance the accuracy and reliability of medical image registration systems. The paper concludes by emphasizing the importance of accurate medical image registration in improving diagnosis. [ABSTRACT FROM AUTHOR]

Subjective well-being (SWB) is a multidimensional construct with three components (i.e., life satisfaction, positive affect, and negative affect) comprising the tripartite model. Yet, despite numerous studies in the field of SWB, the cross-cultural validity of the tripartite structure is still largely unknown. The present study evaluated competing models of SWB’s structure across 16 countries (N = 8860 undergraduate students; age range = 18–29 years; 63.6% female) and examined its measurement invariance using both exact and approximate approaches. The exploratory structural equation model (ESEM) of tripartite SWB that allowed small cross-loadings provided the best fit to the data in the majority of countries, and it demonstrated a high level of approximate invariance, which allows for a comparison of means across countries. A bifactor model with an omitted Positive Affect factor also fit well in all samples making the measurement of the general SWB possible; however, it was less robust for cross-cultural comparisons. The correlations between the three latent SWB factors were consistent across most countries, with a few meaningful exceptions. We conclude that ESEM model represents the tripartite structure of SWB robustly both within and across countries. [ABSTRACT FROM AUTHOR]

Purpose: The aim of this study was to evaluate the role of leg alignment on long‐term clinical outcome after matrix‐associated autologous chondrocyte implantation (M‐ACI) and to define an individualized target range to optimize clinical outcome. Methods: The present study examined patients who underwent M‐ACI of the femoral condyle. The Knee Injury and Osteoarthritis Outcome Score (KOOS) and Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) were used to assess the results. Clinical outcomes were related to Patient Acceptable Symptomatic State (PASS). For intra‐ and interobserver reliability of mechanical tibiofemoral angle, mechanical medial proximal tibial angle and mechanical lateral distal femoral angle, we calculated intraclass correlation coefficients using a two‐way mixed model with absolute agreement. A regression model and receiver‐operating characteristics curve were used to identify an individual range of alignment where a favourable clinical outcome could be expected in the long term. Results: Additional osteotomy was performed in 50% of patients with similar clinical outcomes as physiologically aligned patients (p > 0.05). The curve‐fitting regression model identified a target range of −2.5° valgus to 4.5° varus for ideal postoperative alignment (R2 = 0.12, p = 0.01). Patients within this range were more likely to achieve PASS (70% vs. 27%, p = 0.001). In medially treated defects, a refined range of −2.5° valgus to 4° varus alignment was found (R2 = 0.15, p = 0.01). These patients were more likely to achieve PASS (67% vs. 30%, p = 0.01) and showed favourable postoperative KOOS and MOCART scores (p = 0.02). Patients with lateral defects were more likely to achieve PASS within a range of −2° valgus and 0.5° varus (90% vs. 45%, p = 0.03) and showed favourable postoperative KOOS and MOCART scores (p = not significant). Conclusions: An individual range of leg alignment—whether achieved by osteotomy or physiologic alignment—should be respected in M‐ACI treatment. A neutral to slightly undercorrected alignment favours the postoperative outcome after M‐ACI. When planning surgery for patients with focal cartilage defects of the femoral condyle, these ranges should be recognized as critical factors. Level of Evidence: Level III. [ABSTRACT FROM AUTHOR]

Varus deformity is common in medial compartment knee osteoarthritis (OA). This coronal plane malalignment is compensated for by static and dynamic adjustments in the position of the adjacent joints, principally in the hindfoot & ankle. Varus knee OA can be treated in selected patients with high tibial osteotomy (HTO) and stabilised with a fixed angle plate or circular frame, which may reverse these compensatory adjustments. The aim of this systematic review is to determine the evidence available for static and dynamic compensations with the main objectives being to improve deformity planning and optimise patient outcomes. A systematic review with meta-analysis was designed using the PRISMA template to meet the research aims & objectives. A total of 1006 patients (1020 knees) with acombined mean age of 54.5 years, female:male ratio of 0.9:1 were extracted from 19 included studies. The methodologies of the majority of studies were at high risk of bias according to the Newcastle-Ottawa Scale demonstrating significant heterogeneity. The combined mean change in the HKA axis was 7.7°; MPTA 7.4°; TT, 0.21°; TI 4.56° & AJLO 4° valgus. Preoperative hindfoot valgus compensation reverts towards neutral post-HTO. There is limited evidence available for a direct relationship between static alignment and dynamic gait parameters. An inverse relationship between ankle and hindfoot alignment in varus deformity of the knee forms the basis of this compensation theory. In cases with a stiff hindfoot which may not revert postoperatively, the reconstructive orthopaedic surgeon may consider angulation with translation HTO, in order to optimise joint alignment and minimise transference of symptoms to the foot and ankle. [ABSTRACT FROM AUTHOR]

Inclusive education is vital for creating a nurturing learning environment for students with disabilities, but disparities in attitudes and practices among school administrators can hinder its effective implementation. This study explores the attitudes of school administrators and teachers toward inclusion across three dimensions: resources, training, and general attitudes. Emphasizing the need for alignment, the study proposes a targeted training program to guide educators in optimizing teaching for students with special needs. The study assesses the acceptability of this training initiative, aiming for a unified approach to inclusive education. In a quantitative, non-experimental study, 343 public school administrators and 5040 teachers were surveyed using a carefully tailored instrument with high reliability (Cronbach's alpha = 0.93). Data analysis employing an average weighted mean and a t-test reveals a significant difference in attitudes between teachers and administrators. A proposed training program aligning with the Minnesota Department of Education's mission is informed by these findings. Table 6 confirms high acceptability among participants, substantiating the program's feasibility and potential positive impact on inclusive education practices in public schools. Collectively, Tables 3, 4, 5, and 6 provide a comprehensive snapshot of attitudes, perceptions, and responses toward inclusive education. Public school teachers exhibit a generally positive inclination toward inclusion, while administrators strongly support inclusive education principles. However, Table 5 signals a significant difference between teacher and administrator attitudes, necessitating alignment. Table 6 underscores the proposed training program's high acceptability, emphasizing the importance of addressing attitude discrepancies and implementing targeted training for a unified and effective approach to inclusive education in schools. [ABSTRACT FROM AUTHOR]

Aramid nanofibers (ANFs) are a strong and heat‐resistant nanomaterial that can be isolated from commercial para‐aramid fibers, which allow a bottom‐up self‐assembly to form ordered macroscale structures like ANF films. However, the anisotropic nature of high aspect ratio ANFs is not fully exploited when fabricating ANF films for the optimal mechanical properties. In this research, direct ink writing (DIW) is applied to produce ANF‐assembled films with arbitrary shapes, and the shear‐induced alignment of ANFs can follow the printing path direction. Therefore, controlled alignment of ANFs following the computer‐programmed printing pattern is achieved by DIW, which provides a path for the application of topology and nanofiber alignment optimization in nanofiber‐assembled films. In addition, the resulting DIW ANF films exhibit outstanding Young's modulus of 8.39 GPa, tensile strength of 198 MPa, and tensile toughness of 19.4 MJ m−3 in the alignment direction, together with a wide working temperature range up to 440 °C without losing 50% of its room temperature storage modulus. Moreover, the demonstrated self‐joining ability, rollability, and lamination processability of the DIW ANF films expand their potential applications toward high‐temperature ultrathin tubes, substrates for flexible printed circuit boards, and three‐dimensional all‐ANF lightweight structural parts in extreme environments. [ABSTRACT FROM AUTHOR]

The ability to manipulate the absorption, scattering, or reflectivity of light using synthetic materials has inspired innovations in nano‐ and micro‐materials for applications ranging from geoengineering to display optics. Asymmetric materials, like Janus particles, offer one solution to meet the needs of such technologies, as composition and geometry can be optimized to maximize directional optical properties in response to magnetic and/or electric fields, light, or electrostatic charge. In this work, a gram‐scale synthesis is applied to generate Janus matchstick particles comprising a gold head with a silica rod. Conditions are explored and optimized to elicit rotation of these matchstick particles under an alternating current (AC) electric field with varying field strength and frequency to maximize particle alignment. While only modest changes in transmission (≈8%) are observed over the visible spectral region with a bare silica rod, the application of an absorbing element increased transmission changes up to ≈23% demonstrating their utility as color‐changing materials. Experimental results are supported by theory and computation and highlight an important first step in activating directional optical effects in these materials which can be optimized for future adaptive technologies. [ABSTRACT FROM AUTHOR]

A hybrid chitosan-based nanocomposite was fabricated by chitin nanowhiskers coupled with silanized Fe3O4 nanoparticles as a polyelectrolyte membrane for direct methanol fuel cells (DMFCs). The morphological evaluations articulated that the magnetite nanoparticles were uniformly attached to the chitin nanowhiskers. After characterization of the synthesized nanowhiskers, they were incorporated into the chitosan, as a polycationic electrolyte, to investigate the performance of nanocomposite for DMFC applications. An external magnetic field was applied to the magnetic chitin nanowhiskers to induce alignment, and the effects of aligned nanowhiskers, as well as random ones, were also studied. The magnetic chitin nanowhiskers positively influenced the water uptake and proton conductivity due to the formation of hydrogen bonds between the surface functional groups of nanowhiskers and free water molecules. On the other hand, methanol permeation of the chitosan nanocomposites was reduced regarding the tortuous pathways and narrower transportation channels by the presence of nanowhiskers. [ABSTRACT FROM AUTHOR]

The management and processing of synchrotron and neutron computed tomography data can be a complex, labor‐intensive and unstructured process. Users devote substantial time to both manually processing their data (i.e. organizing data/metadata, applying image filters etc.) and waiting for the computation of iterative alignment and reconstruction algorithms to finish. In this work, we present a solution to these problems: TomoPyUI, a user interface for the well known tomography data processing package TomoPy. This highly visual Python software package guides the user through the tomography processing pipeline from data import, preprocessing, alignment and finally to 3D volume reconstruction. The TomoPyUI systematic intermediate data and metadata storage system improves organization, and the inspection and manipulation tools (built within the application) help to avoid interrupted workflows. Notably, TomoPyUI operates entirely within a Jupyter environment. Herein, we provide a summary of these key features of TomoPyUI, along with an overview of the tomography processing pipeline, a discussion of the landscape of existing tomography processing software and the purpose of TomoPyUI, and a demonstration of its capabilities for real tomography data collected at SSRL beamline 6‐2c. [ABSTRACT FROM AUTHOR]

In the process of transtibial prosthetic fitting, alignment is the process of positioning the prosthetic foot relative to the residual limb. Changes in frontal plane alignment can impact knee moments during walking, which can either cause or, when aligned properly, prevent injuries. However, clinical evaluation of dynamic knee moments is challenging, limiting prosthetists' insights into dynamic joint loading. Typically, knee joint loading is assessed in static stance using the knee moment arm as a proxy for subsequent dynamic alignment. It remains uncertain if static alignment accurately represents actual dynamics during walking. Is the frontal knee moment arm in stance predictive for the knee moment arm and external knee adduction moment during gait in transtibial bone-anchored prosthesis users? In this cross-sectional study, twenty-seven unilateral transtibial bone-anchored prosthesis users underwent data acquisition on the M-Gait instrumented treadmill. Static and dynamic measurements were conducted, and knee moment arm and external knee adduction moment were calculated. Pearson's correlation and linear regression analyses were performed to examine relationships between static and dynamic knee moment arms and external knee adduction moments. The static knee moment arm showed significant associations with dynamic knee moment arm at the ground reaction force peaks (First: r=0.60, r2=35%, p<0.001; Second: r=0.62, r2=38%, p=0.001) and knee adduction moment (First: r=0.42, r2=17%, p=0.030; Second: r=0.59, r2=35%, p=0.001). A 1 mm between-subject difference in static knee moment arm corresponded, on average, with a 0.9% difference in knee adduction moment at the first peak and a 1.5% difference at the second peak of the ground reaction force. While static alignment is important to optimize adduction moments during stance it may only partly mitigate excessive moments during gait. The fair correlation and limited percentage of explained variance underscores the importance of dynamic alignment in optimizing the body's dynamic load during walking. • Static KMA has a fair to good correlation to dynamic KMA in transtibial amputees. • KMA has a very good to excellent correlation to the external knee adduction moment. • There is a limited explained variance of static KMA to the dynamic parameters. • A 1 mm static KMA shift causes a 1% dynamic adduction moment change. [ABSTRACT FROM AUTHOR]

Introduction: Spinopelvic mobility drives functional acetabular position, influencing dislocation risk after total hip arthroplasty (THA). Patients have been described as "stuck sitting" or "stuck standing" based on pelvic tilt (PT). We hypothesised that some patients are "stuck in the middle," meaning their PT changes minimally from sitting to standing – increasing their risk of dislocation. Methods: We reviewed 195 patients with standing and sitting whole body radiographs prior to THA. Standing anterior pelvic plane tilt (APPT) and standing and sitting sacral slope (SS) were measured and used to calculate sitting APPT. Normal standing and sitting were defined as APPT >−10° and <−20°, respectively. Spinal stiffness was classified as <10° change in sacral slope between sitting and standing. Patients were categorised as: (A) able to fully sit and stand; (B) "stuck sitting" - able to fully sit; unable to fully stand; (C) "stuck standing" - able to fully stand; unable to fully sit; or (D) "stuck in the middle" - unable to sit or stand fully. Results: 84 patients could sit and stand normally (A), 22 patients were stuck sitting (B), 76 patients were stuck standing (C), and 13 patients were stuck in the middle (D). While 111 patients (56.9%) were considered stuck, only 58 patients (29.7%) met criteria for spinal stiffness. Discussion: We identified a subset of patients with stiff spines and abnormal PT in both sitting and standing, including 37.1% of patients who would be classified as "stuck sitting" based only on standing radiographs. Placing acetabular components in less than anatomic anteversion in these patients may increase posterior dislocation risk. [ABSTRACT FROM AUTHOR]

Recent years have seen a dramatic increase in the number of canine genome assemblies available. Duplications are an important source of evolutionary novelty and are also prone to misassembly. We explored the duplication content of nine canine genome assemblies using both genome self-alignment and read-depth approaches. We find that 8.58% of the genome is duplicated in the canFam4 assembly, derived from the German Shepherd Dog Mischka, including 90.15% of unplaced contigs. Highlighting the continued difficulty in properly assembling duplications, less than half of read-depth and assembly alignment duplications overlap, but the mCanLor1.2 Greenland wolf assembly shows greater concordance. Further study shows the presence of multiple segments that have alignments to four or more duplicate copies. These high-recurrence duplications correspond to gene retrocopies. We identified 3,892 candidate retrocopies from 1,316 parental genes in the canFam4 assembly and find that ∼8.82% of duplicated base pairs involve a retrocopy, confirming this mechanism as a major driver of gene duplication in canines. Similar patterns are found across eight other recent canine genome assemblies, with metrics supporting a greater quality of the PacBio HiFi mCanLor1.2 assembly. Comparison between the wolf and other canine assemblies found that 92% of retrocopy insertions are shared between assemblies. By calculating the number of generations since genome divergence, we estimate that new retrocopy insertions appear, on average, in 1 out of 3,514 births. Our analyses illustrate the impact of retrogene formation on canine genomes and highlight the variable representation of duplicated sequences among recently completed canine assemblies. [ABSTRACT FROM AUTHOR]

Purpose: When planning and delivering total knee arthroplasty (TKA), there are multiple coronal alignment strategies such as functional alignment (FA), kinematic alignment (KA), mechanical and adjusted mechanical alignment (MA, aMA). Recent three‐dimensional and robotic‐assisted surgery (RAS) studies have demonstrated that KA potentially better restores the trochlear anatomy than MA. The purpose of this study was to compare the restoration of the native trochlear orientation in patients undergoing RAS TKA using four different alignment strategies. It was hypothesised that FA would result in the lowest number of outliers. Methods: This is a prospective study of 200 patients undergoing RAS‐TKA with a single implant. All patients were analysed for MA and KA prebalancing, and 157 patients received aMA and 43 patients FA with intraoperative balancing. Preoperative transverse computed tomography scans were used to determine the posterior condylar axis (PCA), lateral trochlear inclination (LTI) angle, sulcus angle (SA) and anterior trochlear line (ATL) angle. Implant measurements were obtained using a photographic analysis. Intraoperative software data combined with implant data and preoperative measurements were used to calculate the differences. Outliers were defined as ≥3° of alteration. Trochlea dysplasia was defined as LTI < 12°. Results: Native transepicondylar PCA had a median of 2°, LTI 18°, SA 137°, ATL 4°. LTI outliers were observed in 47%–60% of cases, with KA < FA < aMA < MA. For ATL, the range of outliers was 40.5%–85%, KA < FA < aMA < MA. SA produced 81% of outliers. Of all median angle values, only LTI when using KA was not significantly altered compared to the native knee. Conclusion: There is a significant alteration of trochlear orientation after TKA, regardless of the alignment strategy used. KA produced the lowest, but a substantial, number of outliers. The uniform design of implants causes the surgeon to compromise on balance in flexion versus trochlear position. The clinical relevance of this compromise requires further clinical investigations. Level of Evidence: Level II, prospective cohort study. [ABSTRACT FROM AUTHOR]

Why have most Latin American countries – traditionally pro‐Atlantic and staunch defenders of non‐intervention – remained conspicuously neutral during the Ukraine War? We argue that in an increasingly bipolar context, fence‐sitting produces clear strategic gains through partner‐diversification and bargaining power. However, this strategy becomes riskier with polarisation and, at a certain point, these risks may upset benefits. We formalise this argument and examine the foreign policy trajectories of several Latin American countries in the context of the Ukraine War to illustrate how their room for diplomatic flexibility has shrunk with polarisation. As a corollary, we think of scenarios where the costs of fence‐sitting can outweigh its advantages, forcing the region to align. [ABSTRACT FROM AUTHOR]

Introduction: There are numerous ways to transfer the alignment of a lower-limb prosthesis that have been used and adapted over the last several decades. The proposed glass tracing alignment method (GTAM) allows for a convenient and rapid transfer of prosthetic alignment in the coronal and sagittal planes with minimal equipment requirements. Objective: The aim of this article is to share a novel method for coronal and sagittal plane prosthetic alignment transfer, which may be done with minimal time, materials, and expense. Materials and Methods: Prosthetic alignment may be transferred in part or in whole by tracing the prosthesis in both the coronal and sagittal planes. The prosthesis must first be stabilized on a surface that allows for the prosthetic foot to be traced and is adjacent to a wall surface that allows for tracing of the prosthesis proximal to the foot. The line of progression (LOP) of the prosthesis should be parallel to the edge of the table it is traced upon and in a vertical orientation when tracing the entire prosthesis in the sagittal plane. When tracing the coronal plane alignment, the foot should be oriented vertically and placed in the LOP. Sagittal and coronal tracings should include as much of the prosthesis as possible to insure the most accurate alignment transfer of components. The GTAM was developed to be a clinical complement to traditional alignment transfer methods, which may include use a vertical or horizontal prosthetic alignment transfer jig. Results: Use of the described alignment tracing technique allows for the rapid alignment transfer of prosthetic componentry for a variety of applications. Conclusions: The GTAM proposed is an easy way for a busy practitioner to certify that alignment transfers have been performed correctly or to preserve alignment when replacing elements of a prosthesis for clinical and/or research applications. [ABSTRACT FROM AUTHOR]

The aim of this article was to identify the embedded Sustainability Development Goals (SDGs) in undergraduate business sustainability programs curricula. A purposive sample of 23 programs was analyzed. The sources of data were the secondary data published by the universities about the program curricula, together with the course descriptions. Course descriptions were analyzed. This study revealed that the most aligned SDG is goal 12: responsible consumption and production. The programs were clustered according to the sustainability dimensions of the embedded SDGs in three general clusters. The courses differed in their alignment with the SDGs. This is one of the few studies investigating the degree of alignment between the undergraduate curricula of business sustainability programs and the SDGs. [ABSTRACT FROM AUTHOR]

Distal extremity misalignment may give rise to pelvic floor dysfunctions (PFDs). This study aimed to compare pelvic floor muscle strength (PFMS) and dysfunctions in women with and without pes planus. Women with (pes planus group, n = 30) and without pes planus (control group, n = 30) were included. The presence of PFDs questioned. Pes planus with the Feiss Line Test, PFMS with the Modified Oxford Scale, and the severity of PFDs with the Pelvic Floor Distress Inventory-20 (PFDI-20), including three subscales (Pelvic Organ Distress Inventory-6 (POPDI-6) for pelvic organ prolapse, Colorectal-Anal Distress Inventory-8 (CRADI-8) for colorecto-anal symptoms, and Urinary Distress Inventory-6 (UDI-6) for urinary symptoms, were assessed. It was seen that no difference was found between groups in terms of PFMS (p > 0.05). However, urinary incontinence and anal incontinence were higher in women with pes planus than in women without pes planus (p < 0.05). Only the PFDI-20, CRADI-8, and UDI-6 scores were higher in women with pes planus compared to controls (p < 0.05). There was no difference was found between groups in terms of POPDI-6 scores (p > 0.05). The PFMS did not change according to the presence of pes planus. However, the prevalence of PFDs and their severity were higher in women with pes planus in comparison to controls. Posture assessments of individuals with PFDs, especially examination of foot posture, and pelvic floor assessments of individuals with posture disorders should be considered. [ABSTRACT FROM AUTHOR]

Background: Pressure distribution in the ankle joint is known to be dependent on various factors, including hindfoot alignment. We seek to evaluate how hindfoot alignment affects contact pressures in the ankle joint in the setting of supination external rotation (SER) type ankle fractures. Methods: SER fractures were created in 10 human cadaver lower extremity specimens, simulating progressive stages of injury: without fracture (step 0), SER fracture and intact deltoid ligament (step 1), superficial deltoid ligament disruption (step 2), and deep deltoid ligament disruption (step 3). At each step, varus and valgus alignment was simulated by displacing the calcaneal tuberosity 7 mm medial or lateral. Each limb was axially loaded following each osteotomy at a static load of 350 N. The center of force (COF), contact area (CA), and peak contact pressure (PP) under load were measured, and radiographs of the ankle mortise were taken to analyze the medial clear space (MCS) and talar tilt (TT). Results: The COF (5.3 mm, P =.030) and the CA (−188.4 mm2, P =.015) changed in step 3 in the valgus hindfoot alignment compared to baseline parameters, indicating the importance of deep deltoid ligament integrity in maintaining normal ankle joint contact stress in the valgus hindfoot. These changes were not seen in the setting of varus alignment (COF: 2.3 mm, P =.059; CA −121 mm2, P =.133). PP were found to not change significantly in either varus or valgus (varus: −4.9 N, P =.132; valgus: −4 N, P =.464). The MCS demonstrated widening in step 3 compared to step 2 (0.7 mm, P =.020) in both varus and valgus hindfoot. The TT increased significantly in step 3 in the valgus hindfoot (2.8 degrees, P =.020) compared to step 0. Conclusion: SER-IV fractures with valgus hindfoot alignment showed significant changes in pressure distribution and radiographic parameters when compared to SER-IV fractures with varus hindfoot alignment. Clinical Relevance: Based on this cadaver modeling study, patients with SERIV fracture with varus hindfoot alignment and complete deltoid ligament lesion may not need fracture fixation, whereas those with valgus hindfoot alignment likely need fracture fixation. [ABSTRACT FROM AUTHOR]

Copyright of Acta Materiae Compositae Sinica is the property of Acta Materiea Compositae Sinica Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Overlay accuracy, one of the three fundamental indicators of lithography, is directly influenced by alignment precision. During the alignment process based on the Moiré fringe method, a slight angular misalignment between the mask and wafer will cause the Moiré fringes to tilt, thereby affecting the alignment accuracy. This paper proposes a leveling strategy based on the DQN (Deep Q-Network) algorithm. This strategy involves using four consecutive frames of wafer tilt images as the input values for a convolutional neural network (CNN), which serves as the environment model. The environment model is divided into two groups: the horizontal plane tilt environment model and the vertical plane tilt environment model. After convolution through the CNN and training with the pooling operation, the Q-value consisting of n discrete actions is output. In the DQN algorithm, the main contributions of this paper lie in three points: the adaptive application of environmental model input, parameter optimization of the loss function, and the possibility of application in the actual environment to provide some ideas. The environment model input interface can be applied to different tilt models and more complex scenes. The optimization of the loss function can match the leveling of different tilt models. Considering the application of this strategy in actual scenarios, motion calibration and detection between the mask and the wafer provide some ideas. To verify the reliability of the algorithm, simulations were conducted to generate tilted Moiré fringes resulting from tilt angles of the wafer plate, and the phase of the tilted Moiré fringes was subsequently calculated. The angle of the wafer was automatically adjusted using the DQN algorithm, and then various angles were measured. Repeated measurements were also conducted at the same angle. The angle deviation accuracy of the horizontal plane tilt environment model reached 0.0011 degrees, and the accuracy of repeated measurements reached 0.00025 degrees. The angle deviation accuracy of the vertical plane tilt environment model reached 0.0043 degrees, and repeated measurements achieved a precision of 0.00027 degrees. Moreover, in practical applications, it also provides corresponding ideas to ensure the determination of the relative position between the mask and wafer and the detection of movement, offering the potential for its application in the industry. [ABSTRACT FROM AUTHOR]

Multi-modal fusion technology gradually become a fundamental task in many fields, such as autonomous driving, smart healthcare, sentiment analysis, and human-computer interaction. It is rapidly becoming the dominant research due to its powerful perception and judgment capabilities. Under complex scenes, multi-modal fusion technology utilizes the complementary characteristics of multiple data streams to fuse different data types and achieve more accurate predictions. However, achieving outstanding performance is challenging because of equipment performance limitations, missing information, and data noise. This paper comprehensively reviews existing methods based on multi-modal fusion techniques and completes a detailed and in-depth analysis. According to the data fusion stage, multi-modal fusion has four primary methods: early fusion, deep fusion, late fusion, and hybrid fusion. The paper surveys the three major multi-modal fusion technologies that can significantly enhance the effect of data fusion and further explore the applications of multi-modal fusion technology in various fields. Finally, it discusses the challenges and explores potential research opportunities. Multi-modal tasks still need intensive study because of data heterogeneity and quality. Preserving complementary information and eliminating redundant information between modalities is critical in multi-modal technology. Invalid data fusion methods may introduce extra noise and lead to worse results. This paper provides a comprehensive and detailed summary in response to these challenges. [ABSTRACT FROM AUTHOR]

Abstract: Convergence science is an intrepid form of interdisciplinarity defined by the US National Research Council as ‘the coming together of insights and approaches from originally distinct fields’ to strategically address grand challenges. Despite its increasing relevance to science policy and institutional design, there is still no practical framework for measuring convergence. We address this gap by developing a measure of disciplinary distance based upon disciplinary boundaries delineated by hierarchical ontologies. We apply this approach using two widely used ontologies—the Classification of Instructional Programs and the Medical Subject Headings—each comprised of thousands of entities that facilitate classifying two distinct research dimensions, respectively. The social dimension codifies the disciplinary pedigree of individual scholars, connoting core expertise associated with traditional modes of mono-disciplinary graduate education. The conceptual dimension codifies the knowledge, methods, and equipment fundamental to a given target problem, which together may exceed the researchers’ core expertise. Considered in tandem, this decomposition facilitates measuring social-conceptual alignment and optimizing team assembly around domain-spanning problems—a key aspect that eludes other approaches. We demonstrate the utility of this framework in a case study of the human brain science (HBS) ecosystem, a relevant convergence nexus that highlights several practical considerations for designing, evaluating, institutionalizing, and accelerating convergence. Econometric analysis of 655,386 publications derived from 9,121 distinct HBS scholars reveals a 11.4% article-level citation premium attributable to research featuring full topical convergence, and an additional 2.7% citation premium if the social (disciplinary) configuration of scholars is maximally aligned with the conceptual (topical) configuration of the research.

Abstract Objective This study aims to quantitatively assess the relationship between the patella alignment and morphology and knee osteoarthritis (KOA), as well as the kinematics and kinetics of the knee, using gait analysis. Methods Eighty age-matched patients with KOA and control subjects were evaluated. Incident radiographic osteoarthritis (iROA) was identified using a Kellgren-Lawrence (KL) grade of ≥ 2. The modified Insall-Salvati ratio (Mod-ISR), patellar tilt angle (PTA), and patella index (PI) were utilized to evaluate the sagittal and transverse alignment of the patella and its morphology, respectively. Regression analyses were conducted to explore associations between patellar measurements and KOA, iROA, kinematics, and kinetics. Results Significant differences were observed between the control and KOA groups in terms of KL grade, patella alta, abduction angle, and reaction force to the ground (P 0.05, respectively). Conclusion This study provides further evidence that proper alignment and morphology of the patella might be associated with maintaining normal biomechanical function. In addition, intervention measures targeting relevant patellar parameters, such as Mod-ISR, PTA, and PI, may positively impact KOA treatment outcomes.

Abstract Minimizing negative impacts of Artificial Intelligent (AI) systems on human societies without human supervision requires them to be able to align with human values. However, most current work only addresses this issue from a technical point of view, e.g., improving current methods relying on reinforcement learning from human feedback, neglecting what it means and is required for alignment to occur. Here, we propose to distinguish strong and weak value alignment. Strong alignment requires cognitive abilities (either human-like or different from humans) such as understanding and reasoning about agents’ intentions and their ability to causally produce desired effects. We argue that this is required for AI systems like large language models (LLMs) to be able to recognize situations presenting a risk that human values may be flouted. To illustrate this distinction, we present a series of prompts showing ChatGPT’s, Gemini’s and Copilot’s failures to recognize some of these situations. We moreover analyze word embeddings to show that the nearest neighbors of some human values in LLMs differ from humans’ semantic representations. We then propose a new thought experiment that we call “the Chinese room with a word transition dictionary”, in extension of John Searle’s famous proposal. We finally mention current promising research directions towards a weak alignment, which could produce statistically satisfying answers in a number of common situations, however so far without ensuring any truth value.

Abstract Background Spatial transcriptomics (ST) is advancing our understanding of complex tissues and organisms. However, building a robust clustering algorithm to define spatially coherent regions in a single tissue slice and aligning or integrating multiple tissue slices originating from diverse sources for essential downstream analyses remains challenging. Numerous clustering, alignment, and integration methods have been specifically designed for ST data by leveraging its spatial information. The absence of comprehensive benchmark studies complicates the selection of methods and future method development. Results In this study, we systematically benchmark a variety of state-of-the-art algorithms with a wide range of real and simulated datasets of varying sizes, technologies, species, and complexity. We analyze the strengths and weaknesses of each method using diverse quantitative and qualitative metrics and analyses, including eight metrics for spatial clustering accuracy and contiguity, uniform manifold approximation and projection visualization, layer-wise and spot-to-spot alignment accuracy, and 3D reconstruction, which are designed to assess method performance as well as data quality. The code used for evaluation is available on our GitHub. Additionally, we provide online notebook tutorials and documentation to facilitate the reproduction of all benchmarking results and to support the study of new methods and new datasets. Conclusions Our analyses lead to comprehensive recommendations that cover multiple aspects, helping users to select optimal tools for their specific needs and guide future method development.

The management and processing of synchrotron and neutron computed tomography data can be a complex, labor-intensive and unstructured process. Users devote substantial time to both manually processing their data (i.e. organizing data/metadata, applying image filters etc.) and waiting for the computation of iterative alignment and reconstruction algorithms to finish. In this work, we present a solution to these problems: TomoPyUI, a user interface for the well known tomography data processing package TomoPy. This highly visual Python software package guides the user through the tomography processing pipeline from data import, preprocessing, alignment and finally to 3D volume reconstruction. The TomoPyUI systematic intermediate data and metadata storage system improves organization, and the inspection and manipulation tools (built within the application) help to avoid interrupted workflows. Notably, TomoPyUI operates entirely within a Jupyter environment. Herein, we provide a summary of these key features of TomoPyUI, along with an overview of the tomography processing pipeline, a discussion of the landscape of existing tomography processing software and the purpose of TomoPyUI, and a demonstration of its capabilities for real tomography data collected at SSRL beamline 6-2c.

Patients with knee osteoarthritis and varus knee deformity have impaired postural balance, resulting in decreased walking performance and an increased risk of falls. This study aimed to investigate the early changes in the postural balance following inverted V-shaped high tibial osteotomy (HTO). Fifteen patients with medial knee osteoarthritis were recruited. Postural balance was assessed using the center-of-pressure (COP) data during single-leg standing before and 6 weeks after inverted V-shaped HTO. The maximum range, mean velocity, and area of COP movements in the anteroposterior and mediolateral directions were analyzed. Preoperative and postoperative visual analog scale for knee pain was assessed. The maximum range of COP in the mediolateral direction decreased (P =.017), whereas the mean velocity of COP in the anteroposterior direction increased 6 weeks postoperatively (P =.011). The visual analog scale score for knee pain significantly improved at 6 weeks postoperatively (P =.006). Valgus correction with inverted V-shaped HTO resulted in improved postural balance in the mediolateral direction and good short-term clinical outcomes early following surgery. Early rehabilitation after inverted V-shaped HTO should focus on postural balance in the anteroposterior direction. [ABSTRACT FROM AUTHOR]