1. First-episode psychosis is associated with oxidative stress: Effects of short-term antipsychotic treatment
- Author
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Uludağ Üniversitesi/Tıp Fakültesi/Psikiyatri Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Klinik Biyokimya Anabilim Dalı., Sarandöl, Aslı, Sarandöl, Emre, Açıkgöz, Hacer Ebru, Eker, Salih Saygın, Akkaya, Cengiz, Dirican, Melahat, ABE-1716-2020, and Q-9477-2019
- Subjects
Male ,Erythrocytes ,Antipsychotic agents ,ALB protein, human ,Serum albumin ,Carboxylesterase ,Low-density-lipoprotein ,Plasma ,Malondialdehyde ,Antioxidant defense ,Vitamin E ,Disease ,Arylesterase ,Protein blood level ,Enzyme activity ,Psychiatry ,Psychotic disorders ,Neuroleptic agent ,Malonaldehyde ,Drug-naive patients ,APOB protein, human ,First-episode psychosis ,Erythrocyte ,Blood ,Clinical neurology ,Apolipoprotein B-100 ,Female ,Antioxidant ,Apolipoprotein B ,Human ,Vitamin blood level ,Adult ,Clinical article ,Case control study ,Case-control studies ,Superoxide dismutase ,Patient care ,Neurosciences & neurology ,Pathophysiology ,Article ,Oxidation ,Carboxylic ester hydrolases ,Humans ,Clinical evaluation ,Lipid peroxide ,Onset ,Oxidative Stress ,Acetylcysteine ,Bipolar Disorder ,Drug effects ,Aryldialkylphosphatase ,Albumin ,Neurosciences ,Alpha tocopherol ,Bilirubin ,Psychosis ,Affective disorders ,Oxidation-reduction ,Young adult ,Metabolism ,Sschizophrenia ,Oxidative stress ,Susceptibility ,Short course therapy ,Schizophrenia ,Glutathione peroxidase ,Apolipoprotein B100 ,Oxidation reduction reaction ,Uric acid ,Controlled study ,Enzyme blood level - Abstract
AimsIn the present study, our aim was to investigate the oxidative-antioxidative systems in unmedicated first-episode psychosis (FEP) patients at the beginning and after short-term treatment. MethodsThis study consisted of 29 patients who experienced an FEP and 25 control subjects. In order to investigate the oxidative status, we determined plasma malondialdehyde (MDA) levels, oxidizability of red blood cells, oxidation and oxidizability of apolipoprotein B-containing lipoproteins (apo B-basal MDA and apo B-MDA). In order to evaluate the antioxidative defense, we measured serum total antioxidative capacity, uric acid, albumin, total bilirubin and vitamin E levels and serum paraoxonase/arylesterase, whole blood glutathione peroxidase (GPx) and red blood cell superoxide dismutase activities before and after 6 weeks of treatment in patients with FEP. ResultsPlasma MDA and apo B-basal MDA levels and red blood cell superoxide dismutase activity were significantly higher and serum arylesterase and whole blood-GPx activities were lower in the FEP group than those of the healthy control group. There were not any significant changes in the oxidative and antioxidative system parameters (except increased vitamin E levels) after treatment. ConclusionsThe results of this study suggest that FEP is accompanied by oxidative stress. However, further studies are needed to clarify the role of oxidative stress in the physiopathologic mechanisms of FEP, so that oxidative and antioxidative system parameters can be used in the management of these patients. In accordance with psychiatric evaluation, for a better management, patients with FEP may require a multidisciplinary approach, including oxidative and antioxidative system parameters.
- Published
- 2015