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22 results on '"AKI, NANAKO"'

9. Fermented soy food and inflammatory makers

Author

Yang, Xiaolin, Nakamoto, Mariko, Shuto, Emi, Hata, Akiko, Aki, Nanako, Shikama, Yosuke, Bando, Yukiko, Ichihara, Takako, Minagawa, Takako, Kuwamura, Yumi, Tamura, Ayako, Uemura, Hirokazu, Arisawa, Kokichi, Funaki, Makoto, and Sakai, Tohru

Subjects
Soy, Inflammation, Interleukin-6, digestive, oral, and skin physiology, Fermented soy food
Abstract

Epidemiological investigations have shown that consumption of soybeans or soy foods reduces the risk of the development of cardiovascular disease, cancer and osteoporosis. The aim of this study was to determine the associations between different soy foods and inflammatory markers, including high-sensitivity C-reactive protein (hs-CRP), interleukin (IL)-6, and IL-18, in Japanese workers. The cross-sectional study included 1,426 Japanese workers (1,053 men and 373 women) aged 20 to 64 years. Intake of 12 soy foods was estimated by a validated food frequency questionnaire. Associations of total soy foods, fermented soy food, non-fermented soy food, soy isoflavone with hs-CRP, IL-6, and IL-18 levels were examined by general linear model regression analysis. We found that total fermented soy food intake was inversely associated with multivariable-adjusted geometric concentration of IL-6 in men (Q1 : 1.03 pg/mL, Q5 : 0.94 pg/mL ; P for trend = 0.031). Furthermore, it was shown that IL-6 concentrations were inversely associated with miso intake (β= -0.068 ; p = 0.034) and soy sauce intake in men (β= -0.074 ; p = 0.018). This study suggests that intake of total fermented soy food, miso and soy sauce be associated with IL-6 concentrations in Japanese men.

Published
2018

11. Dietary diversity and characteristics of lifestyle and awareness of health in Japanese workers : a cross-sectional study

Author

Nakamoto, Mariko, primary, Yun, Yuna, additional, Omine, Mariko, additional, Mori, Sarasa, additional, Shuto, Emi, additional, Nakamoto, Akiko, additional, Hata, Akiko, additional, Aki, Nanako, additional, Shikama, Yosuke, additional, Bando, Yukiko, additional, Ichihara, Takako, additional, Minagawa, Takako, additional, Tamura, Ayako, additional, Kuwamura, Yumi, additional, Funaki, Makoto, additional, and Sakai, Tohru, additional

Published
2020
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13. Associations between intake of dietary fermented soy food and concentrations of inflammatory markers: a cross‐sectional study in Japanese workers

Author

Yang, Xiaolin, primary, Nakamoto, Mariko, additional, Shuto, Emi, additional, Hata, Akiko, additional, Aki, Nanako, additional, Shikama, Yosuke, additional, Bando, Yukiko, additional, Ichihara, Takako, additional, Minamigawa, Takako, additional, Kuwamura, Yumi, additional, Tamura, Ayako, additional, Uemura, Hirokazu, additional, Arisawa, Kokichi, additional, Funaki, Makoto, additional, and Sakai, Tohru, additional

Published
2018
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15. Cut-Off Value of Total Adiponectin for Managing Risk of Developing Metabolic Syndrome in Male Japanese Workers

Author

Hata, Akiko, primary, Yonemoto, Koji, additional, Shikama, Yosuke, additional, Aki, Nanako, additional, Kosugi, Chisato, additional, Tamura, Ayako, additional, Ichihara, Takako, additional, Minagawa, Takako, additional, Kuwamura, Yumi, additional, Miyoshi, Masashi, additional, Nakao, Takayuki, additional, and Funaki, Makoto, additional

Published
2015
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18. Diabetic Conditions Differentially Affect the Endothelial Function, Arterial Stiffness and Carotid Atherosclerosis

Author

Kinouchi, Mizuho, primary, Aihara, Ken-ichi, additional, Fujinaka, Yuichi, additional, Yoshida, Sumiko, additional, Ooguro, Yukari, additional, Kurahashi, Kiyoe, additional, Kondo, Takeshi, additional, Aki, Nanako, additional, Kuroda, Akio, additional, Endo, Itsuro, additional, Matsuhisa, Munehide, additional, and Matsumoto, Toshio, additional

Published
2014
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19. Singlet Oxygen Induced Products of Linoleates, 10- and 12-(Z,E)-Hydroxyoctadecadienoic Acids (HODE), Can Be Potential Biomarkers for Early Detection of Type 2 Diabetes

Author

Umeno, Aya, primary, Shichiri, Mototada, additional, Ishida, Noriko, additional, Hashimoto, Yoshiko, additional, Abe, Kaori, additional, Kataoka, Masatoshi, additional, Yoshino, Kohzoh, additional, Hagihara, Yoshihisa, additional, Aki, Nanako, additional, Funaki, Makoto, additional, Asada, Yasuhiko, additional, and Yoshida, Yasukazu, additional

Published
2013
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20. Period between Dinner and Bedtime Is Related to Hypertension

Author

Nakamoto, Mariko, primary, Sakai, Tohru, additional, Shuto, Emi, additional, Aki, Nanako, additional, Kosugi, Chisato, additional, Hata, Akiko, additional, Shinoda, Kaori, additional, Kuwamura, Yumi, additional, Minamigawa, Takako, additional, Ichihara, Takako, additional, Tamura, Ayako, additional, and Funaki, Makoto, additional

Published
2013
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21. Palmitate-Stimulated Monocytes Induce Adhesion Molecule Expression in Endothelial Cells via IL-1 Signaling Pathway.

Author

Shikama, Yosuke, Aki, Nanako, Hata, Akiko, Nishimura, Miho, Oyadomari, Seiichi, and Funaki, Makoto

Subjects
*TYPE 2 diabetes risk factors, *VASCULAR endothelial cells, *CARDIOVASCULAR diseases risk factors, *CELL adhesion molecules, *GENE expression, *MONOCYTES
Abstract

Increased intake of saturated fatty acids (SFAs), such as palmitate (Pal), is linked to a higher risk of type 2 diabetes and cardiovascular disease. Although recent studies have investigated the direct effects of SFAs on inflammatory responses in vascular endothelial cells, it remains unknown whether SFAs also induce these responses mediated by circulating cells. In this study, especially focused on adhesion molecules and monocytes, we investigated the indirect effects of Pal on expression and release of ICAM-1 and E-selectin in vascular endothelial cells. Phorbol 12-myristate 13-acetate (PMA)-treated THP-1 (pTHP-1) cells and human monocytes were stimulated with various free fatty acids (FFAs). SFAs, but not unsaturated fatty acids (UFAs), increased interleukin (IL)-1β secretion and decreased IL-1 receptor antagonist (IL-1Ra) secretion, resulting in an increase in the IL-1β/IL-1Ra secretion ratio. UFAs dose-dependently inhibited the increase in IL-1β secretion and decrease in IL-1Ra secretion induced by Pal. Moreover, in human aortic and vein endothelial cells, expression and release of ICAM-1 and E-selectin were induced by treatment with conditioned medium collected from Pal-stimulated pTHP-1 cells and human monocytes, but not by Pal itself. The up-regulated expression and release of adhesion molecules by the conditioned medium were mostly abolished by recombinant human IL-1Ra supplementation. These results suggest that the Pal-induced increase in the ratio of IL-1β/IL-1Ra secretion in monocytes up-regulates endothelial adhesion molecules, which could enhance leukocyte adhesion to endothelium. This study provides further evidence that IL-1β neutralization through receptor antagonism may be useful for preventing the onset and development of cardiovascular disease. J. Cell. Physiol. 230: 732-742, 2015. © 2014 Wiley Periodicals, Inc., A Wiley Company [ABSTRACT FROM AUTHOR]

Published
2015
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