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Tracking the dynamic modules during cancer progression is essential for studying cancer pathogenesis, diagnosis and therapy. However, current algorithms only focus on detecting dynamic modules from temporal cancer networks without integrating the heterogeneous genomic data, thereby resulting in undesirable performance. To attack this issue, a novel algorithm (aka TANMF) is proposed to detect dynamic modules in cancer temporal attributed networks, which integrates the temporal networks and gene attributes. To obtain the dynamic modules, the temporality and gene attributed are incorporated into an overall objective function, which transforms the dynamic module detection into an optimization problem. TANMF jointly decomposes the snapshots at two subsequent time steps to obtain the latent features of dynamic modules, where the attributes are fused via regulations. Furthermore, L1 constraint is imposed to improve the robustness. Experimental results demonstrate that TANMF is more accurate than state-of-the-art methods in terms of accuracy. By applying TANMF to breast cancer data, the obtained dynamic modules are more enriched by the known pathways and associated with the survival time of patients. The proposed model and algorithm provide an effective way for the integrative analysis of heterogeneous omics.

Abstract: Severe Acute Respiratory Syndrome (SARS) aka SARS-CoV spread over southern China for the first time in 2002-2003 and history repeated again since last year and took away lives of more than two million people so far. On March 11, 2020 COVID-19 outbreak was officially declared as pandemic by World Health Organization (WHO). The entire world united to fight back against this ultimate destruction. Around 90 vaccines are featured against SARS-CoV-2 and more than 300 active clinical trials are underway by several groups and individuals. So far, no drugs have been currently approved that can completely eliminate the deadly coronavirus. The promising SARS-CoV-2 antiviral drugs are favipiravir, remdesivir, lopinavir, ribavirin and avifavir. In this review, we have discussed the synthetic approaches elaborately made so far by different groups and chemical companies all around the world towards top three convincing anti-viral drugs against SARS-CoV-2, which are favipiravir, remdesivir and lopinavir.

Microgreens growing under electric (artificial) lighting in controlled environments often have short hypocotyls, which can be difficult for machine harvest. To investigate whether early-stage dark treatment can promote hypocotyl elongation without compromising microgreen yield and quality, two different seed-size species, sunflower (Helianthus annuus ‘Black oil’) and arugula (Eruca sativa ‘Rocket’), were tested. Seeds of sunflower and arugula were sown in pots, and the pots were placed inside support trays. During the first 5 days after seeding, half of the pots per species within each tray were covered with an upside-down black tray as dark treatment, and another half were kept under light. The light treatment was provided by continuous (24-h) lighting with a combination of red (85%) and blue (15%) light-emitting diodes at a photosynthetic photo flux density of around 100 μmol·m−2·s−1. After 5 days of dark treatment, the black covers were removed and the plants were grown under the above lighting treatment till harvesting. The microgreens were harvested at 7 d and 12 d after seeding for sunflower and arugula, respectively. Early-stage dark treatment promoted hypocotyl elongation by 26% and 28% for sunflower and arugula, respectively. Microgreen yield was increased by 13% for sunflower and reduced by 24% for arugula under dark treatment. Dark treatment increased cotyledon succulence by 14% for sunflower, but reduced cotyledon size by about 25% for arugula despite increases in red color and succulence of arugula hypocotyls. For both species, cotyledon color and soluble solids content were not affected by dark treatment.

In the first days of 2020, the nations of Europe could hardly imagine that their lives were going to change so drastically in a couple of months. SARS – Covid 19, aka coronavirus resulted in a great change in all societies on the globe. Most countries introduced a state of emergency and made restrictions on many aspects of people’s lives. The present paper intends to give an overview of the measures that the Hungarian government has taken so far. For this purpose, it first analyses the legal background of state of emergency that would help understand the present situation. Secondly, it describes the measures taken, and finally it evaluates how the measures affect human rights, especially free movement, freedom of enterprise and free speech.

Since 2016, all of four major U.S. operators have rolled out Wi-Fi calling services. They enable mobile users to place cellular calls over Wi-Fi networks based on the 3GPP IMS technology. Compared with conventional cellular voice solutions, the major difference lies in that their traffic traverses untrusted Wi-Fi networks and the Internet. This exposure to insecure networks can cause the Wi-Fi calling users to suffer from security threats. Its security mechanisms are similar to the VoLTE, because both of them are supported by the IMS. They include SIM-based security, 3GPP AKA, IPSec, etc. However, are they sufficient to secure Wi-Fi calling services? Unfortunately, our study yields a negative answer. We conduct the first security study on the operational Wi-Fi calling services in three major U.S. operators networks using commodity devices. We disclose that current Wi-Fi calling security is not bullet-proof and uncover three vulnerabilities. By exploiting the vulnerabilities, we devise two proof-of-concept attacks: telephony harassment or denial of voice service and user privacy leakage; both of them can bypass the existing security defenses. We have confirmed their feasibility using real-world experiments, as well as assessed their potential damages and proposed a solution to address all identified vulnerabilities.

Host-based Intrusion Detection Systems (HIDS) automatically detect events that indicate compromise by adversarial applications. HIDS are generally formulated as analyses of sequences of system events such as bash commands or system calls. Anomaly-based approaches to HIDS leverage models of normal (a.k.a. baseline) system behavior to detect and report abnormal events and have the advantage of being able to detect novel attacks. In this article, we develop a new method for anomaly-based HIDS using deep learning predictions of sequence-to-sequence behavior in system calls. Our proposed method, called the ALAD algorithm, aggregates predictions at the application level to detect anomalies. We investigate the use of several deep learning architectures, including WaveNet and several recurrent networks. We show that ALAD empowered with deep learning significantly outperforms previous approaches. We train and evaluate our models using an existing dataset, ADFA-LD, and a new dataset of our own construction, PLAID. As deep learning models are black box in nature, we use an alternate approach, allotaxonographs, to characterize and understand differences in baseline vs. attack sequences in HIDS datasets such as PLAID.

The number of Clar covers, the number of Kekule structures, and the Clar covering polynomials (aka Zhang–Zhang or ZZ polynomials) of benzenoid parallelogram chains M k m , n formed by merging k benzenoid parallelograms M m , n are characterized in terms of analogous quantities of the elementary building block, M m , n . The appropriate formulas are compactly expressed as determinants of highly structured, tridiagonal, Toeplitz k × k matrices. All the 2 k distinct parallelogram chains M k m , n ≡ M 1 M 2 … M k of constant length k , where M i ∈ R ≡ M m , n , L ≡ M n , m , share the same ZZ polynomial and consequently possess the same number of Clar covers and Kekule structures. The presented results constitute the first attempt to express the Clar theory of complex benzenoid moieties in terms of elementary benzenoids.

Acquiring expertise in a task is often thought of as an automatic process that follows inevitably with practice according to the log-log law (aka: power law) of learning. However, as Ericsson, Chase, and Faloon (1980) showed, this is not true for digit-span experts and, as we show, it is certainly not true for Tetris players at any level of expertise. Although some people may simply "twitch" faster than others, the limit to Tetris expertise is not raw keypress time but the techniques acquired by players that allow them to use the tools provided by the hardware and software to compensate for the game's relentlessly increasing drop speed. Unfortunately, these increases in drop speed between Tetris levels make performance plateaus very short and quickly followed by game death. Hence, a player's success at discovering, exploring, and practicing new techniques for the tasks of board preparation, board maintenance, optimal placement discovery, zoid rotation, lateral movement of zoids, and other tasks important to expertise in Tetris is limited. In this paper, we analyze data collected from 492 Tetris players to reveal the challenges they confronted while constructing expertise via the discovery of new techniques for gameplay at increasingly difficult levels of Tetris.

In this example, you learned how to implement two versions of the game known as memory or concentration) using programming techniques and HTML5 features. These included examples of programmer-defined functions and programmer-defined objects how to draw polygons on the canvas using moveTo and lineTo along with Math trig methods guidance on how to use a form to show information to players a method for drawing text with a specified font on the canvas instructions about how to draw images on the canvas using setTimeout to force a pause employing Date objects to compute elapsed time

The article is the result of mapping the cultural space of Gorce. Using the tools of cultural map-ping and spatial turn, the Gorce mnemotoposes were analyzed and a map of the cultural spheres of the influence of regional actors on the creation of local genius loci was developed. The research focused on the presence of memory sites related to the World War II period and the participants of partisan actions in the Gorce region. The memory of Władysław Orkan, Józef Tischner and Tomasz Chlipała aka “Bulanda” also plays an important role in shaping the cultural landscape of Gorce.

An ordered relation of structure and function has been a cornerstone in thinking about brain organization. Like the brain itself, however, this is not straightforward and is confounded both by functional intricacy and structural plasticity (many routes to a given outcome). As a striking case of putative structure–function correlation, this mini-review focuses on the relatively well-characterized pattern of cytochrome oxidase (CO) blobs (aka “patches” or “puffs”) in the supragranular layers of macaque monkey visual cortex. The pattern is without doubt visually compelling, and the semi-dichotomous array of CO+ blobs and CO− interblobs is consistent with multiple studies reporting compartment-specific preferential connectivity and distinctive physiological response properties. Nevertheless, as briefly reviewed here, the finer anatomical organization of this system is surprisingly under-investigated, and the relation to functional aspects, therefore, unclear. Microcircuitry, cell type, and three-dimensional spatiotemporal level investigations of the CO+ CO− pattern are needed and may open new views to structure–function organization of visual cortex, and to phylogenetic and ontogenetic comparisons across nonhuman primates (NHP), and between NHP and humans.

Patients frequently verbalize memory complaints that require evaluation. A brief objective screening test of short-term aka episodic memory would be useful. Assessment of verbal episodic memory is a central factor in neurocognitive status, frequently evaluated with list learning and memory tests. Currently, normed list learning tests of verbal episodic memory are mostly high demand, long, and composed of unrelated items and thus can be onerous and disinteresting for certain populations, such as those who are cognitively limited, elderly, or poorly motivated. Presented here are initial performance data for a brief, low demand, readily accepted nine-item grocery list test, derived from the Dementia Assessment Battery, including three learning trials and one delayed recall trial. With this data set, the test can thus be useful in a wide range of assessment circumstances including screening, brief evaluations, mental status evaluations, and bedside deployment.

Edgar Arceneaux, Zora Arceneaux Holding Her Vice President Kamala Harris Blue Pineapple Upside Down Cake, Studio Edgar Arceneaux, 2021 (artwork © Zora Arceneaux; photograph provided by Edgar Arcene...

While it is permissible to switch the trolley in the classic Switch case, it is not permissible to push the stranger in the classic Footbridge (aka, ‘Push’) case. But what may we do in cases that offer both a ‘switch-like’ option and a ‘push-like’ option? Surprisingly, we may choose the push-like option, provided that it has better consequences than the switch-like option. We arrive at this conclusion by taking ourselves seriously – not just as agents who might redirect threats – but as threats who might be redirected by agents.

In this paper, I investigate dānměi as a ground-breaking literary genre by means of scrutinising an illustrious male writer pseudonymed Fēitiānyèxiáng, and I propound that his works are exemplary as online writing. As a growing Chinese Internet literature, the female-oriented dānměi genre, aka Boys Love, has attracted legions of heterosexual fangirl producers and consumers as well as a meagre amount of their male counterparts. Among male dānměi writers, who are in an absolute minority, Fēitiānyèxiáng is celebrated for a wide range of innovative themes and magnificent storylines, and his fiction is replete with profound literary and historical allusions and elaborate and meticulous depictions. Furthermore, notwithstanding a non-reversible bipartite dichotomy between seme (top) and uke (bottom) roles, Fēitiānyèxiáng’s writing is not featured by feminisation of uke, which is clichéd characterisation in not only the dānměi subculture, but also classical and modern Chinese literature. More significantly, Fēitiānyèxiáng’s narratives are reality-oriented, addressing adverse circumstances in a real-world context and hence rendering characters more multi-faceted, and he does not circumvent realistic issues or create over-romanticised representation, analogous to his equivalent pseudonymed Nánkāngbáiqǐ.

Introduction: Systemic sclerosis (aka scleroderma) is an autoimmune disease with no known definitive etiology, but genetic, infectious, and non-infectious exposures have been associated with its occurrence. Previous studies have shown that systemic sclerosis can be a paraneoplastic phenomenon and may be associated with increased risk of malignancy, most commonly lung, skin, and breast cancers. The association of renal cell carcinoma with systemic sclerosis is rare. Case Description: Here, we present a case of a 75-year-old male patient with a rapidly progressive scleroderma despite the initial treatment with methotrexate and prednisone 5 mg daily. Shortly after the diagnosis of scleroderma, the patient was found to have a renal mass. The patient underwent a right partial nephrectomy revealing papillary renal cell carcinoma. The surgical margin was negative indicating complete removal of the cancer. The patient, later, developed scleroderma renal crisis and progressed to end-stage renal disease despite treatment with captopril, mycophenolate mofetil, plasmapheresis, and intravenous immunoglobulin. Conclusions: The purpose of this case report and literature review is to highlight that diffuse scleroderma can potentially be paraneoplastic from a renal cell carcinoma and to add more data to the literature given there are only a handful of reported cases. Our patient is unique in the sense that he was discovered to have renal cell carcinoma shortly after being diagnosed with scleroderma suggesting a paraneoplastic etiology yet continued to worsen despite full resection of the renal cell carcinoma. This is in contrast to the other reported cases of renal cell carcinoma associated scleroderma where scleroderma worsened around the time of the diagnosis of renal cell carcinoma and improved after nephrectomy. There also are case reports of the patients with renal cell carcinoma associated scleroderma where the patient had scleroderma for several years before the diagnosis of renal cell carcinoma, which raises the question, if scleroderma could also represent a risk factor for developing renal cell carcinoma.

Teehuteatuaonoa (or ‘Jenny’ by her English nickname) was one of 12 Polynesian women reaching Pitcairn Island with the HMS Bounty mutineers in 1790. She was the most traveled of these women and the first to return to Tahiti after 29 years away. Her journey is chronicled with Google Earth using a screenshot and caption for each waypoint. The journey included 15 links totaling 24,090 km or 60% of the Earth’s circumference. Her longest link was 7,400 km aboard the Sultan, an American ship from Boston, which brought her from Coquimbo, Chile, to The Marquesas. Jenny’s life provides an excellent example of female agency during a period controlled and reported on by men. Her life epitomized Nicholas Thomas’ understanding that islander-empire contact during the 18th and 19th Centuries involved both survival and suffering, invention and exploitation.

A study was done to describe awareness, knowledge and attitude level on Urinary Tract Infection among university students of Burapha University, Thailand. Cross-sectional study was conducted with the use of self-modified questionnaire consisting of socio-demographic questions and AKA domains. Total of 91 respondents (male students n=13 and female n=76) aged 19 years old participated. The total AKA level was found to be in high category (75.86 ± 13.81) and between the domains, Attitude (70.00 ± 13.28) is categorized as positive, followed by both Knowledge (57.24 ± 15.94) and Awareness (39.37 ± 13.01) which is categorized as moderate. Correlation between Awareness-Attitude was found significant at p=0.003. After the adjustment of covariates, female gender was found to have the strongest relationship compared to other covariates and all independent factors combined accounted 14.8% of variability in Total AKA. The sociodemographic factors’ of the students influenced the level of AKA and female gender have found to have be best predictor for Total AKA on UTI. Thus, this research has provided ample findings to further formulate an educational tool for the public.

The stereoselectivity and yield in glycosylation reactions are paramount but unpredictable. We have developed a database of acceptor nucleophilic constants (Aka) to quantify the nucleophilicity of hydroxyl groups in glycosylation influenced by the steric, electronic and structural effects, providing a connection between experiments and computer algorithms. The subtle reactivity differences among the hydroxyl groups on various carbohydrate molecules can be defined by Aka, which is easily accessible by a simple and convenient automation system to assure high reproducibility and accuracy. A diverse range of glycosylation donors and acceptors with well-defined reactivity and promoters were organized and processed by the designed software program "GlycoComputer" for prediction of glycosylation reactions without involving sophisticated computational processing. The importance of Aka was further verified by random forest algorithm, and the applicability was tested by the synthesis of a Lewis A skeleton to show that the stereoselectivity and yield can be accurately estimated.

The Ise monogatari ( The Ise Stories , aka Tales of Ise , tenth cen.) is the oldest continuously illustrated secular narrative in Japanese history. The present article explores to what extent, and how, contemporary manga artists engage with or use this rich visual tradition, examining three examples, in the seinen (young male-oriented), shōjo (young female-oriented), and gyagu (gag) genres, yet all arguably categorizable as gakushū , or educational, manga. Perhaps surprisingly, only the gag manga artist, Kurogane Hiroshi, takes advantage of the Ise ’s long visual history, and the author of the article concludes by drawing parallels with the early modern artistic practice of mitate-e , or visual parody.

This viewpoint discusses the legacy that my grandmother, Norah Dacre Fox (aka Norah Elam), left to me as a result of her political campaigning during the period 1900-1945. Norah, together with Mary...

Sweet syndrome aka acute febrile neutrophilic dermatosis is one of the serious dermatological condition which goes undiagnosed due to several reasons. Unawareness of this condition may be one of the primary factors for missing the diagnosis which may lead to inaccurate treatment which may only lead to worsening the condition in a sick individual. Very few studies have been published in this area, hence the present investigator felt the need of reviewing few literatures and creating a material which will aid in early and accurate diagnosis of the condition. About 20 literature was reviewed based on the history, presentation, diagnosis and its probable homoeopathic treatment accordingly. All the information required for accurate diagnosis and its homeopathic approach was compiled into the present paper.

At its inception in the 19th-century, the talking telegraph (AKA the telephone) was an amazing feat of engineering using analog technology. One could speak into a micro-phone in one city and be heard in another city. Accom-plishing this required a very large investment in technol-ogy. The customers were consumers of the service.

A fundamental layer of smart cities, the Internet of Vehicles (IoV) can significantly improve transportation efficiency, reduce energy consumption, and traffic accidents. However, because of the vehicle and the RoadSide Units (RSU) use wireless channels for communication, the risk of information being leaked or tampered is highly increased. Therefore, secure and reliable authentication and key agreement protocol is the masterpiece of IoV security. As most of the existing authentication protocols pertain to a centralized structure and single Trusted Authority (TA) network model, all vehicles involved can only perform mutual authentication with one TA through the intermediate node RSU, and thus, the efficiency of these centralized authentication protocols is easily affected by TA’s communication and computing resource bottlenecks. In this article, a blockchain-based authentication and key agreement protocol is designed for the multi-TA network model, moving the computing load of TA down to the RSU to improve the efficiency of authentication. In addition, blockchain technology is used for multiple TAs to manage the ledger that stores vehicle-related information, which results in vehicles that can easily achieve cross-TA authentication. Both formal and informal security analysis and simulation results from ProVerif show that the proposed protocol is secure. Comparisons with other existing work show that the proposed protocol has less computational overhead, higher authentication efficiency, and can resist various common attacks.

Numerous application domains in practice related to target- tracking, monitoring, and transportation have utilized the wide usage of Wireless Sensor Networks (WSN’s) technology. These domains use physical networking objects connecting over the Internet to collect and exchange the data. Using the advancement of cloud computing technologies and aggravation of big-data growth caused by the incorporation of the Internet of Things (IoT), secure user authentication for remote access is playing a crucial role. Since it has limited authorization and authentication privileges for mobility users, an approach of mobile-sink has been instigated for the improvisation of remote user authentication i.e. cloud-based IoT applications. As a result, this article proposes a lightweight smartcard based secure authentication (LS-BSA) approach using the mathematical assumption of bilinear-pairing/mapping, elliptic-curve cryptosystems, and fuzzy verifier. An extensive security investigation demonstrates that the proposed LS-BSA not only guarantees the AKA security properties but also prevents significant vulnerabilities. Furthermore, the proposed LS-BSA uses lightweight operations to establish a seamless data connectivity over a secure network. It maintains the compatibility standards including low-cost and low-power to mitigate the computation and communication cost of cloud-based intelligent data computing. Formal security verification of BAN-logic is introduced to show that LS-BSA offers proper mutual user authentication and secret secure-session key agreement between the real-time entities. In addition, a network scenario has been set up using the NS-3 simulator to prove that the proposed LS-BSA is more efficient than other existing schemes in terms of packet delivery ratio, end-to-end delay, and throughput rate.