Search

Your search keyword '"AITA, KIYOSHI"' showing total 15 results
Start Over Author "AITA, KIYOSHI"
15 results on '"AITA, KIYOSHI"'

9. A role for apoptosis induced by acute herpes simplex virus infection in mice

Author

A. Hajime Koyama, Aita Kiyoshi, and Hiroshi Irie

Subjects
Genes, Viral, viruses, Immunology, Myenteric Plexus, Ovary, Apoptosis, Herpesvirus 1, Human, Biology, Protein Serine-Threonine Kinases, medicine.disease_cause, Virus, Mice, Viral Proteins, Immune system, Adrenal Glands, medicine, Immunology and Allergy, Animals, Myenteric plexus, Adrenal cortex, Macrophages, Brain, Herpes Simplex, Virology, medicine.anatomical_structure, Herpes simplex virus, Viral replication, Pituitary Gland, Female
Abstract

Acute herpes simplex virus (HSV) infection causes apoptosis in the adrenal cortex and myenteric plexus of the gut, ovary, pituitary gland, and liver of mice. Apoptosis of infected cells is increased in immunosuppressed regions of the adrenal cortex and liver of macrophage-depleted mice. HSV carries the US3 gene which interferes with host cell apoptosis. When the livers of macrophage-depleted mice are infected with a US3-null virus, apoptosis occurs in the narrow areas of inflammatory cell infiltration, restricting viral replication and spread. Thus, these data suggest that apoptosis may function as a primitive immune response to HSV infection in mice.

Published
2003

12. Herpes encephalitis complicated during the recovery stage of fluminant hepatitis

Author

HANAWA, Naoko, primary, NAGAYAMA, Ryozo, additional, KURIHARA, Hiroko, additional, TAKAYANAGI, Motoe, additional, TACHIZAWA, Hidetaka, additional, TAKAMORI, Yoriyuki, additional, TAKIKAWA, Hajime, additional, FUKUSHIMA, Jun-ichi, additional, FUKUSATO, Toshio, additional, SHIGA, Junji, additional, AITA, Kiyoshi, additional, and NAKANO, Imaharu, additional

Published
2004
Full Text
View/download PDF

15. The Role of Donor CD4+ T Cells in the Reconstitution of Oral Immunity by Herpes Simplex Virus Type 1 in Severe Combined Immunodeficiency Mice.

Author

Irie, Hiroshi, Aita, Kiyoshi, Koyama, A. Hajime, Fukuda, Akio, Yoshida, Takeshi, and Shiga, Junji

Subjects
*HERPES simplex virus, *SPLEEN, *CYTOLOGY
Abstract

Severe combined immunodeficiency (SCID) mice with ill-developed Peyer's patches develop neither antibodies nor protection against lethal herpes simplex virus type 1 (HSV-1) infection by oral immunization. However, SCID mice carrying spleen cells from immunocompetent BALB/c mice had serum anti-HSV-1 antibody; anti-HSV-1 IgA antibody was detected in eye wash samples, and the mice were protected against lethal HSV-1 infection (88% survival rate). Western blotting showed that antibodies in SCID mice carrying spleen cells from BALB/c mice recognized 60-kDa HSV-1. The effector cells in transferred spleen cells were CD4+, not CD8+, T cells. Donor T cells were detected in the submucosal layer of the gut in SCID mice 1 day after transfer. Rapid movement of donor T cells to the gut may have a role in mucosal immunity to HSV-1. Thus, the normal environment for mucosal immunity develops in SCID mice without prior presence of CD4+ T cells. [ABSTRACT FROM AUTHOR]

Published
2002
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results