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5 results on '"AIEOP ITP STUDY, Group"'

1. Management strategies for newly diagnosed immune thrombocytopenia in Italian AIEOP Centres: do we overtreat? Data from a multicentre, prospective cohort study

Author

Emilia Parodi 1, Giovanna Russo 2, Piero Farruggia 3, Lucia D Notarangelo 4, Maria T Giraudo 5, Margherita Nardi 6, Fiorina Giona 7, Paola Giordano 8, Ugo Ramenghi 1, 'AIEOP-ITP Study Group' (Appendix 1), Angelica Barone 9, Gianluca Boscarol 10, Simone Cesaro 11, Francesca Fioredda 12, Saverio Ladogana 13, Maria Licciardello 14, Francesca Rossi, Laura Rubert 16, Marco Spinelli 17, Fabio Tucci 1, 1, Emilia Parodi, 2, Giovanna Russo, 3, Piero Farruggia, D Notarangelo 4, Lucia, T Giraudo 5, Maria, 6, Margherita Nardi, 7, Fiorina Giona, 8, Paola Giordano, 1, Ugo Ramenghi, Study Group' (Appendix 1), 'AIEOP-ITP, 9, Angelica Barone, Boscarol 10, Gianluca, Cesaro 11, Simone, Fioredda 12, Francesca, Ladogana 13, Saverio, Licciardello 14, Maria, Rossi, Francesca, Rubert 16, Laura, Spinelli 17, Marco, and 1, Fabio Tucci

Abstract

Background: The aim of the present study was to assess management strategies for immune thrombocytopenia (ITP) among Italian paediatric haematologists, and to compare these with those of recent international guidelines. Predictors of early remission or disease chronicity were also evaluated. Materials and methods: During a period of 1 year, 205 children (age: 1 month-18 years) with newly diagnosed ITP were prospectively enrolled by 16 centres belonging to the Italian Association of Paediatric Haematology and Oncology (AIEOP). We collected the subjects demographic data, history, clinical symptoms, platelet count and treatment at presentation and at subsequent visits. Results: Of the 205 patients, 47 (23%) were initially managed with a wait-and-see approach. Compared to these patients, children administered platelet-enhancing therapies were significantly younger (median age: 4.75 vs 7.96 years; p

Published
2020

2. Management of Chronic Childhood Immune Thrombocytopenic Purpura: AIEOP Consensus Guidelines

Author

De Mattia D, Del Vecchio GC, Russo G, De Santis A, Ramenghi U, Notarangelo L, Jankovic M, Molinari AC, Zecca M, Nobili B, Giordano P, AIEOP ITP Study Group, Acquaviva A, Amendola G, Baronci C, Binda S, Bisogno G, Bussetti C, Ciliberti A, Citterio M, Del Principe D, Farruggia P, Ladogana S, Magro S, Masera G, Menichelli A, Nardi M, Parodi E, Tucci F, Vimercati C., PESSION, ANDREA, DE MATTIA, D, DEL VECCHIO, Gc, Russo, G, DE SANTIS, A, Ramenghi, U, Notarangelo, L, Jankovic, M, Molinari, Ac, Zecca, M, Nobili, Bruno, Giordano, P, AIEOP ITP STUDY, Group, De Mattia D, Del Vecchio GC, Russo G, De Santis A, Ramenghi U, Notarangelo L, Jankovic M, Molinari AC, Zecca M, Nobili B, Giordano P, and AIEOP-ITP Study Group,Acquaviva A, Amendola G, Baronci C, Binda S, Bisogno G, Bussetti C, Ciliberti A, Citterio M, Del Principe D, Farruggia P, Ladogana S, Magro S, Masera G, Menichelli A, Nardi M, Parodi E, Pession A, Tucci F, Vimercati C.

Subjects
Pediatrics, medicine.medical_specialty, Platelet count, Adolescent, Consensus Development Conferences as Topic, Prednisolone, Rho(D) Immune Globulin, medicine.medical_treatment, conta piastrinica, Splenectomy, Platelet Transfusion, management of pediatric thrombocytopenia, idiopathic thrombocytopenic purpura, platelet count, trattamento della piastrinopenia pediatrica, porpora trombocitopenica idiopatica, Immune system, immune system diseases, hemic and lymphatic diseases, medicine, Pediatric thrombocytopenia, Humans, Platelet, Idiopathic thrombocytopenic purpura, Management of pediatric thrombocytopenia, Thrombocytopenia, Child, Purpura, Thrombocytopenic, Idiopathic, biology, business.industry, Immunoglobulins, Intravenous, Infant, Hematology, General Medicine, medicine.disease, Thrombocytopenic purpura, Purpura, Chronic disease, Platelet transfusion, Child, Preschool, Chronic Disease, biology.protein, Antibody, medicine.symptom, business, Idiopathic thrombocytopenic purpura, Management of pediatric thrombocytopenia, Pediatric thrombocytopenia, Platelet count, Thrombocytopenia
Abstract

Background/Objective: The management of chronic childhood idiopathic thrombocytopenic purpura (ITP) is distinct from acute ITP. Similar to the publication on acute ITP guidelines, the AIEOP (Associazione Italiana di Ematologia e Oncologia Pediatrica) considered it appropriate to develop consensus guidelines for chronic childhood ITP to provide useful and shared information for physicians, healthcare professionals, parents and patients. Design/Methods: A preliminary, evidence-based document issued by a select group of AIEOP pediatric hematologists was discussed, modified and approved during a Consensus Conference according to procedures previously validated by the AIEOP Board. Results: The guidelines give prominence to the periodical reevaluation of all the etiological hypotheses of thrombocytopenia in relation to its clinical condition. The majority of chronic ITP children do not require treatment, especially if bleeding is absent or minimal. The treatment decision depends on several factors other than the platelet count, and treatment options are suggested in relation to the therapeutic scenarios. Recommendations are given regarding support for surgery, particular hemorrhagic conditions, daily activities/sports, as well as for vaccines and drugs. Experimental treatments are also discussed.

Published
2010

3. Effect of eradication of Helicobacter pylori in children with chronic immune thrombocytopenia: a prospective, controlled, multicenter study

Author

RUSSO G, MIRAGLIA V, BRANCIFORTE F, MATARESE SM, ZECCA M, BISOGNO G, PARODI E, AMENDOLA G, GIORDANO P, JANKOVIC M, CORTI A, NARDI M, FARRUGGIA P, BATTISTI L, BARONCI C, PALAZZI G, TUCCI F, CEPPI S, RAMENGHI U, DE MATTIA D, NOTARANGELO L, AIEOP ITP STUDY GROUP, NOBILI, Bruno, Russo, G, Miraglia, V, Branciforte, F, Matarese, Sm, Zecca, M, Bisogno, G, Parodi, E, Amendola, G, Giordano, P, Jankovic, M, Corti, A, Nardi, M, Farruggia, P, Battisti, L, Baronci, C, Palazzi, G, Tucci, F, Ceppi, S, Nobili, Bruno, Ramenghi, U, DE MATTIA, D, Notarangelo, L, and AIEOP ITP STUDY, Group

Published
2011

4. Management of acute childhood idiopathic thrombocytopenic purpura according to AIEOP consensus guidelines:assessment of Italian experience

Author

DEL VECCHIO GC, DE SANTIS A, GIORDANO P, AMENDOLA G, BARONCI C, DEL PRINCIPE D, JANKOVIC M, RAMENGHI U, RUSSO G, ZECCA M, DE MATTIA D. AND AIEOP ITP STUDY GROUP, NOBILI, Bruno, DEL VECCHIO, Gc, DE SANTIS, A, Giordano, P, Amendola, G, Baronci, C, DEL PRINCIPE, D, Nobili, Bruno, Jankovic, M, Ramenghi, U, Russo, G, Zecca, M, and DE MATTIA D., AND AIEOP ITP STUDY GROUP

Published
2008

5. Effect of eradication of Helicobacter pylori in children with chronic immune thrombocytopenia: A prospective, controlled, multicenter study

Author

Russo, G, Miraglia, V, Branciforte, F, Matarese, Sm, Zecca, M, Bisogno, G, Parodi, Emilia, Amendola, G, Giordano, P, Jankovic, M, Corti, A, Nardi, M, Farruggia, P, Battisti, L, Baronci, C, Palazzi, G, Tucci, F, Ceppi, S, Nobili, B, Ramenghi, Ugo, De Mattia, D, Notarangelo, L, and the AIEOP‐ITP Study Group

Subjects
Blood Platelets, Male, medicine.medical_specialty, Adolescent, porpora trombocitopenica immune cronica, Spontaneous remission, macromolecular substances, helicobacter pylori, chronic immune thrombocytopenic purpura, children, bambini, Gastroenterology, Children, chronic ITP, Helicobacter pylori, Helicobacter Infections, Internal medicine, Clarithromycin, medicine, Humans, Child, Omeprazole, Purpura, Thrombocytopenic, Idiopathic, biology, business.industry, Platelet Count, Amoxicillin, Hematology, biology.organism_classification, Anti-Ulcer Agents, Immune thrombocytopenia, Surgery, Anti-Bacterial Agents, Clinical trial, Oncology, Multicenter study, Pediatrics, Perinatology and Child Health, Chronic Disease, Female, business, medicine.drug
Abstract

Background The eradication of Helicobacter pylori has been associated with remission of immune thrombocytopenia (ITP) in approximately half of eradicated patients. Data on children are limited to small case series. Procedure Children from 16 centers in Italy, who were less than 18 years of age and diagnosed with chronic ITP (cITP), were screened for H. pylori infection. Positive patients underwent standard triple therapy with amoxicillin, clarithromycin, and omeprazole. The eradication response was defined as follows: complete response, platelet (PLT) count ≥150 × 109/L; partial response, PLT count of at least 50 × 109/L; no response, PLT count

Published
2011

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