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584 results on '"ACOSTA, Juan Carlos"'

1. The second Latin American catheter ablation registry (“II LAHRS EP registry”)

Author

Rojel Martinez, Ulises, Llorente, José, López Cabanillas, Nestor, Mondragon, Luis Ignacio, Scanavacca, Mauricio Ibrahim, Zerpa Acosta, Juan Carlos, Bautista Vargas, William Fernando, Santillan, María Eugenia, García Frias, Dulce María, Perez Silva, Armando, Onetto, Leonardo, Dal Forno, Alexander, Morales Molina, Hermes Leonel, Abello, Mauricio, Monjes, Enrique, Soto Becerra, Richard, Alfie, Alberto, Diaz Martinez, Juan Carlos, Rodríguez Guerrero, Diego Andres, Patete Ayala, Manuel Felipe, Mêo Neto, Januário de Pardo, Diangelo, Silvano, Jaber, Jefferson, Wayar Caballero, Luis Alberto, Rodriguez Salazar, Edgardo Alfredo, Tortajada, Gustavo, Hardy, Carina, Vidal Bett, Fernando, Fernandez Prado, Hael Lizandro, Chavez Gonzalez, Elibet, Pava, Luis Fernando, Vives Rodríguez, José Enrique, Contreras, Mauricio, Bulnes Garcia, Lenin Rene, Karabut, Eric, Requena Dugun, Ramón Antonio, and Keegan, Roberto

Published
2024
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5. Global availability of parenteral nutrition: Pre- and post-COVID-19 pandemic surveys

Author

Klek, Stanislaw, del Rio Requejo, Isabel Martinez, Hardy, Gil, Francisco, Liza Mei P., Abbasoglu, Osman, Acosta, Juan Carlos Ayala, Granados, Luis Miguel Becerra, Boeykens, Kurt, Carey, Sharon, Chourdakis, Michael, Compher, Charlene, De Cloet, Joeri, Dubrov, Sergiej, Fuentes, Catalina, Sámano, Ana Karina García, Velasquez, María Eloisa García, Goos, Cezanne, Reyes, José Guillermo Gutierrez, Joon, Lee V, Klimasauskas, Andrius, Komsa, Regina, Krznaric, Zeljko, Ljubas, Dina, Moscoso, Claudia P. Maza, Larreategui, Rosa, Mirea, Liliana, Meier, Remy, Nyulasi, Ibolya, Oivind, Irtun, Panisic-Sekeljic, Marina, Poulia, Kalliopi Anna, Rasmussen, Henrik Højgaard, Savino, Patricia, Singer, Pierre, Tamasi, Peter, Uyar, Mehmet, Thu, Nguyen Viet Quynh, Waitzberg, Dan, Weimann, Arved, Wong, Theodoric, Yu, Jianchun, Wojcik, Paulina, and Schneider, Stephane

Published
2024
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7. Author Correction: mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

Author

Herranz, Nicolás, Gallage, Suchira, Mellone, Massimiliano, Wuestefeld, Torsten, Klotz, Sabrina, Hanley, Christopher J., Raguz, Selina, Acosta, Juan Carlos, Innes, Andrew J., Banito, Ana, Georgilis, Athena, Montoya, Alex, Wolter, Katharina, Dharmalingam, Gopuraja, Faull, Peter, Carroll, Thomas, Martínez-Barbera, Juan Pedro, Cutillas, Pedro, Reisinger, Florian, Heikenwalder, Mathias, Miller, Richard A., Withers, Dominic, Zender, Lars, Thomas, Gareth J., and Gil, Jesús

Published
2024
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9. Discovery of senolytics using machine learning

Author

Smer-Barreto, Vanessa, Quintanilla, Andrea, Elliott, Richard J. R., Dawson, John C., Sun, Jiugeng, Campa, Víctor M., Lorente-Macías, Álvaro, Unciti-Broceta, Asier, Carragher, Neil O., Acosta, Juan Carlos, and Oyarzún, Diego A.

Published
2023
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13. Current threats faced by amphibian populations in the southern cone of South America

Author

Kacoliris, Federico Pablo, Berkunsky, Igor, Acosta, Juan Carlos, Acosta, Rodrigo, Agostini, María Gabriela, Akmentins, Mauricio Sebastián, Arellano, María Luz, Azat, Claudio, Bach, Nadia Carla, Blanco, Graciela Mirta, Calvo, Rodrigo, Charrier, Andrés, Corbalán, Valeria, Correa, Claudio, Cuello, María Elena, Deutsch, Camila, Di-Pietro, Diego, Gastón, María Soledad, Gómez-Alés, Rodrigo, Kass, Camila, Kass, Nicolás, Lobos, Gabriel, Martínez, Tomás Agustín, Martínez-Aguirre, Tomás, Mora, Marta, Nieva-Cocilio, Rodrigo, Pastore, Hernán, Pérez-Iglesias, Juan Manuel, Piaggio-Kokot, Lía, Rabanal, Felipe, Rodriguez-Muñoz, Melina Jesús, Sanchez, Laura Cecilia, Tala, Charif, Úbeda, Carmen, Vaira, Marcos, Velasco, Melina Alicia, Vidal, Marcela, and Williams, Jorge Daniel

Published
2022
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15. MYC sensitises cells to apoptosis by driving energetic demand

Author

Edwards-Hicks, Joy, Su, Huizhong, Mangolini, Maurizio, Yoneten, Kubra K., Wills, Jimi, Rodriguez-Blanco, Giovanny, Young, Christine, Cho, Kevin, Barker, Heather, Muir, Morwenna, Guerrieri, Ania Naila, Li, Xue-Feng, White, Rachel, Manasterski, Piotr, Mandrou, Elena, Wills, Karen, Chen, Jingyu, Abraham, Emily, Sateri, Kianoosh, Qian, Bin-Zhi, Bankhead, Peter, Arends, Mark, Gammoh, Noor, von Kriegsheim, Alex, Patti, Gary J., Sims, Andrew H., Acosta, Juan Carlos, Brunton, Valerie, Kranc, Kamil R., Christophorou, Maria, Pearce, Erika L., Ringshausen, Ingo, and Finch, Andrew J.

Published
2022
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16. General Ecology of Patagonian Lizards

Author

Acosta, Juan Carlos, Gómez Alés, Rodrigo, Blanco, Graciela, Escudero, Paula C., Avila, Luciano J., Quintana, Flavio, Series Editor, Avila, Luciano J., Series Editor, González-José, Rolando, Series Editor, Bucci, Sandra J., Series Editor, and Morando, Mariana, editor

Published
2020
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18. Unrevealing Lithium Repositioning in the Hallmarks of Cancer: Effects of Lithium Salts (LiCl and Li 2 CO 3) in an In Vitro Cervical Cancer Model.

Author

García-Acosta, Juan Carlos, Castillo-Montoya, Alejando Israel, Rostro-Alonso, Gareth Omar, Villegas-Vázquez, Edgar Yebrán, Quintas-Granados, Laura Itzel, Sánchez-Sánchez, Luis, López-Muñóz, Hugo, Cariño-Calvo, Lizbeth, López-Reyes, Israel, Bustamante-Montes, Lilia Patricia, Leyva-Gómez, Gerardo, Cortés, Hernán, Jacobo-Herrera, Nadia Judith, García-Aguilar, Rosario, Reyes-Hernández, Octavio Daniel, and Figueroa-González, Gabriela

Subjects
*LITHIUM cells, *THERAPEUTIC use of lithium, *CELL cycle, *PSYCHIATRIC treatment, *GENTIAN violet
Abstract

Lithium, a natural element, has been employed as a mental stabilizer in psychiatric treatments; however, some reports indicate it has an anticancer effect, prompting the consideration of repurposing lithium for cancer treatment. The potential anticancer use of lithium may depend on its form (salt type) and the type of cancer cells targeted. Little is known about the effects of Li2CO3 or LiCl on cancer cells, so we focused on exploring their effects on proliferation, apoptosis, migration, and cell cycle as part of the hallmarks of cancer. Firstly, we established the IC50 values on HeLa, SiHa, and HaCaT cells with LiCl and Li2CO3 and determined by crystal violet that cell proliferation was time-dependent in the three cell lines (IC50 values for LiCl were 23.43 mM for SiHa, 23.14 mM for HeLa, and 15.10 mM for HaCaT cells, while the IC50 values for Li2CO3 were 20.57 mM for SiHa, 11.52 mM for HeLa, and 10.52 mM for HaCaT cells.) Our findings indicate that Li2CO3 and LiCl induce DNA fragmentation and caspase-independent apoptosis, as shown by TUNEL, Western Blot, and Annexin V/IP assay by flow cytometry. Also, cell cycle analysis showed that LiCl and Li2CO3 arrested the cervical cancer cells at the G1 phase. Moreover, lithium salts displayed an anti-migratory effect on the three cell lines observed by the wound-healing assay. All these findings imply the viable anticancer effect of lithium salts by targeting several of the hallmarks of cancer. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Cacalol Acetate as Anticancer Agent: Antiproliferative, Pro-Apoptotic, Cytostatic, and Anti-Migratory Effects.

Author

Rostro-Alonso, Gareth Omar, Castillo-Montoya, Alejandro Israel, García-Acosta, Juan Carlos, Aguilar-Llanos, Erick Fernando, Quintas-Granados, Laura Itzel, Villegas-Vazquez, Edgar Yebrán, García-Aguilar, Rosario, Porras-Vázquez, Samantha Andrea, Bustamante-Montes, Lilia Patricia, Alvarado-Sansininea, Jesús J., Jiménez-Estrada, Manuel, Cariño-Calvo, Lizbeth, Carmen, Manuel González-del, Cortés, Hernán, Leyva-Gómez, Gerardo, Figueroa-González, Gabriela, and Reyes-Hernández, Octavio Daniel

Published
2024
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25. Identification of a P62-TIF-IA axis that drives nucleolar fusion and the senescence associated secretory phenotype

Author

Thoms, Hazel C, primary, Brant, Tyler, additional, Duckett, Katie, additional, Yang, Yizheng, additional, Dong, Jinxi, additional, Wang, Hongfei, additional, Derby, Freya, additional, Akeke, Tumi, additional, Mann, Derek, additional, Millar, Fraser R, additional, Von Kriegsheim, Alex, additional, Acosta, Juan Carlos, additional, Oakley, Fiona, additional, and Stark, Lesley A, additional

Published
2023
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35. Radiología intervencionista en cálculos biliares ¿qué hay de nuevo?

Author

Ramírez Márquez, Sergio Daniel, primary, Arraut Gámez, Rafael Eduardo, additional, Valencia Zapata, Laura Victoria, additional, Casas Ochoa, Kelvin Andres, additional, Sarmiento Herazo, Bryan, additional, Olivera Ochoa, Jose Luis, additional, Causil Vega, Raùl, additional, and Rivera Acosta, Juan Carlos, additional

Published
2023
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41. Biliary senescence affects the transcriptomic landscape of murine hepatocytes

Author

Ferreira, Marisa, Kilpatrick, Alastair, Rodrigo Torres, Daniel, Ferreira-Gonzalez, Sofía, Man, Janet, Aird, Rhona, Gadd, Victoria, Ashmore-Harris, Candice, Esser, Hannah, Macmillan, Mark, Lu, Wei-Yu, Acosta, Juan Carlos, Boulter, Luke, and Forbes, Stuart J

Abstract

Background and Aims: Biliary diseases are often characterised by biliary epithelial cell (BEC) senescence which, together with its senescence-associated secretory phenotype (SASP), is proposed to regulate liver injury. However, the effects of BEC senescence and its SASP on the modulation of hepatocyte biology remain unexplored. Here, we aimed to generate an in vitro model of BEC senescence and study its impact on hepatocyte transcription dynamics.Method: A murine primary BEC line (Ep-CAM+CD24+CD133+) was treated with etoposide (a DNA topoisomerase inhibitor) to induce senescence, which was assessed via microscopy and RT-qPCR. Conditioned medium from senescent BECs was subsequently added to naïve BECs to confirm transmitted BEC senescence.A non-contact insert-based system was then used to co-culture senescent BECs and naïve primary hepatocytes. Bulk RNA-seq and transcriptomic analysis were performed to assess the effects of the BEC SASP in hepatocytes.Results: Senescence and SASP in etoposide-treated BECs were confirmed by a significant increase of senescence-associated beta-galactosidase activity and gene expression of Cdkn1a, Trp53bp1, Il6, Ccl2, Cxcl2, Cx3cl1, Serpine1, Vegfa and Pdgfa. These were accompanied by a decrease in proliferation (EdU fluorescence and Mki67 gene expression).The secretome of senescent BECs promoted secondary senescence and SASP-related gene expression in naïve BECs, including significantly increased Cdkn1a, Cdkn1b, Cx3cl1 and Vegfa. Differential expression and gene set enrichment analyses of RNA-seq data from treated BEC donors confirmed the presence of senescence and SASP-related factors.In hepatocytes exposed to senescent BECs, differential expression of RNA-seq data revealed a significant increase of the SASP-related factor Vcam1. Functional enrichment analysis using the STRING database retrieved the highest enriched terms (false discovery rate [FDR] < 0.0001): (1) decreased “fatty acid omega-oxidation” (enrichment score [ES] 7.65); (2) increased “neutrophil extravasation, and myeloperoxidase” (ES 6.16); and (3) increased “cathelicidin, and neutrophil aggregation” (ES 5.56).Additional terms (FDR < 0.01) included decreased “drug metabolism - cytochrome P450” (ES 4.01); increased “leukocyte migration involved in inflammatory response” (ES 2.58); and increased “regulation of chemokine production” (ES 1.57).Conclusion: Murine BEC senescence was modelled in vitro. In our experimental setting, senescent BECs present SASP features typical of human biliary diseases. Our model revealed several BEC-dependent SASP-induced changes in hepatocytes that reflect structural, metabolic and functional alterations.Together, this data suggests that, in the context of biliary disease, hepatocytes exposed to senescent BECs display decreased metabolism and enhanced immunomodulatory abilities.

Published
2023

43. De la recolección a los agroecosistemas: Soberanía alimentaria y conservación de la biodiversidad

Author

Aguilar Meléndez, Araceli, additional, Peralta de Legarreta, Alberto, additional, Rodríguez Campos, Edmundo, additional, Roma Ardón, Ronny, additional, Felipe, Fulgencio Manuel, additional, Perfecto, Eleuterio Manuel, additional, González, Fidel Eduardo, additional, Escalona Aguilar, Miguel Ángel, additional, Domínguez González, Nancy, additional, Abato Zárate, Marycruz, additional, Zequeira Larios, Carolina, additional, Ogata, Nisao, additional, Contreras Hernández, Armando, additional, Osorio Rosales, María Luisa, additional, Ortega-Argueta, Alejandro, additional, Vázquez Karnstedt, Ana Paulina, additional, Krömer, Thorsten, additional, Acebey, Amparo R., additional, Toledo-Aceves, Tarin, additional, Mac Swiney González, M. Cristina, additional, López-Acosta, Juan Carlos, additional, Velázquez-Rosas, Noé, additional, Rodríguez-Luna, Ernesto, additional, Muñoz-Robles, Carlos, additional, Zamora Pedraza, Gregoria, additional, López-Binnqüist, Citlalli, additional, Sánchez Sánchez, Odilón, additional, Menchaca García, Rebeca A., additional, Lozano Rodríguez, Miguel A., additional, Guillaumín Tostado, Arturo, additional, Hernández Colorado, Ma. Reyna, additional, Silva Rivera, Evodia, additional, Martínez Valdés, Valentina, additional, Rodríguez Luna, Ernesto, additional, and Lascurain Rangel, Maite, additional

Published
2018
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44. Thermal biology and locomotor performance of the Andean lizard Liolaemus fitzgeraldi (Liolaemidae) in Argentina.

Author

Valdez Ovallez, Franco M., Gómez Alés, Rodrigo, Astudillo, Vanesa, Córdoba, Mariela, Fava, Gustavo, Acosta, Rodrigo, Blanco, Graciela, Villavicencio, José, and Acosta, Juan Carlos

Subjects
LIOLAEMUS, BODY temperature, COLD-blooded animals, LIZARDS, BIOLOGY, CLIMATE change
Abstract

Ectotherms thermoregulate to maintain their body temperature within the optimal range needed for performing vital functions. The effect of climate change on lizards has been studied as regards the sensitivity of locomotor performance to environmental temperatures. We studied thermoregulatory efficiency and locomotor performance for Liolaemus fitzgeraldi in the Central Andes of Argentina. We determined body temperature, micro‐environmental temperatures and operative temperatures in the field. In the laboratory, we measured preferred temperatures and calculated the index of thermoregulatory efficiency. We estimated the thermal sensitivity of locomotion by measuring sprint speed (initial velocity and long sprint) and endurance at five different body temperatures. Body temperature was not associated with either micro‐environmental temperature, nor did it show differences with preferred temperatures. Thermoregulatory efficiency was moderate (0.61). Initial velocity and long sprint trials showed differences at different temperatures; however, endurance did not. Moreover, the optimal temperatures for the performance trials showed no significant differences among themselves. We conclude that Liolaemus fitzgeraldi has thermal sensitivity in locomotor performance with respect to body temperature and that it is an eurythermic lizard that experiences a large variation in body temperature and that has thermal flexibility in the cold. [ABSTRACT FROM AUTHOR]

Published
2023
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45. Supplementary Data from In Vivo Modeling of Patient Genetic Heterogeneity Identifies New Ways to Target Cholangiocarcinoma

Author

Younger, Nicholas T., primary, Wilson, Mollie L., primary, Martinez Lyons, Anabel, primary, Jarman, Edward J., primary, Meynert, Alison M., primary, Grimes, Graeme R., primary, Gournopanos, Konstantinos, primary, Waddell, Scott H., primary, Tennant, Peter A., primary, Wilson, David H., primary, Guest, Rachel V., primary, Wigmore, Stephen J., primary, Acosta, Juan Carlos, primary, Kendall, Timothy J., primary, Taylor, Martin S., primary, Sproul, Duncan, primary, Mill, Pleasantine, primary, and Boulter, Luke, primary

Published
2023
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46. Data from In Vivo Modeling of Patient Genetic Heterogeneity Identifies New Ways to Target Cholangiocarcinoma

Author

Younger, Nicholas T., primary, Wilson, Mollie L., primary, Martinez Lyons, Anabel, primary, Jarman, Edward J., primary, Meynert, Alison M., primary, Grimes, Graeme R., primary, Gournopanos, Konstantinos, primary, Waddell, Scott H., primary, Tennant, Peter A., primary, Wilson, David H., primary, Guest, Rachel V., primary, Wigmore, Stephen J., primary, Acosta, Juan Carlos, primary, Kendall, Timothy J., primary, Taylor, Martin S., primary, Sproul, Duncan, primary, Mill, Pleasantine, primary, and Boulter, Luke, primary

Published
2023
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