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5 results on '"ACAR, EMİNE MANOLYA"'

1. Beş Yaş Altı Çocuklarda Akut Otitis Media Tanısı ile Antibiyotik Tercihi ve Antibiyotik Kullanımı Sonrası Gastrointestinal Sistem Yan Etkileri Çok Merkezli Prospektif Gözlemsel Çalışma

Author

TEZER, HASAN, ÇULLAS İLARSLAN, NİSA EDA, KARBUZ, ADEM, ÖZ, FATMA NUR, SÖNMEZ, GÜLSÜM, ÖZDEMİR, HALİL, ALBAYRAK, EDA, TURAL KARA, TUĞÇE, ÇELEBİ, SOLMAZ, KARA, SONER SERTAN, SALİ, ENES, ACAR, EMİNE MANOLYA, KAYA, CEMİL, BOZDEMİR, ŞEFİKA ELMAS, SÜTÇÜ, MURAT, BÜYÜKÇAM, AYŞE, SOMER, AYPER, KARA, ATEŞ, ÇİFTCİ, ERGİN, KARAKAŞLILAR, SABAHAT, ALABAZ, DERYA, and BEDİR, TUĞBA

Published
2018

2. Beş yaş Altı Çocuklarda Akut Otitis Media’xxda Kulak Ağrısında Lokal Lidokaininin Etkinliği ve Güvenirliği Çalışma Pediotal III Ön Sonuçları

Author

SOMER, AYPER, KAYA, CEMİL, ALBAYRAK, EDA, TEZER, HASAN, BEDİR DEMİRDAĞ, TUĞBA, SÖNMEZ, GÜLSÜM, BÜYÜKCAM, AYŞE, KARA, ATEŞ, KARA, SONER SERTAN, ACAR, EMİNE MANOLYA, Öz, FATMA NUR, BOZDEMİR, ŞEFİKA, SÜTÇÜ, MURAT, KARBUZ, ADEM, ÇİFTCİ, ERGİN, ÇULLAS İLARSLAN, NİSA EDA, KARALAŞLILAR, SABAHAT, ÇELEBİ, SOLMAZ, ÖZDEMİR, HALİL, and SALI, ENES

Published
2017

4. Besin alerjisi hastalarında proinflamatuar ve antiinflamatuar belirteçlerin tedavi öncesinde ve sonrasında değerlendirilmesi

Author

Acar, Emine Manolya, Çokuğraş, Aliye Fügen, and Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı

Subjects
Calprotectin, Food hypersensitivity, Interleukin 10, Tumor necrosis factors, Hypersensitivity, Interleukin 6, Allergens, Çocuk Sağlığı ve Hastalıkları, Child Health and Diseases
Abstract

Amaç: Besin alerjisinde tedavi öncesi (TÖ) ve tedavi sonrası (TS) serum TNF-?, IL-6, IL-10 düzeylerini ve dışkı kalprotektin (DK) seviyelerini inceleyerek, bu belirteçlerin hastalıkların tanı ve izlemindeki rolünü değerlendirmek.Hastalar ve yöntem: Çalışma grubuna 0-36 ay arası 60 yeni hasta alındı. 37'si f1 ya da f2 değerlerinden en az biri pozitif saptanan IgE aracılı grubu oluşturan hastalardı. 23'ü ise spesifik IgE değerlerinin negatif olmasına rağmen, eliminasyon diyeti ile bulguları gerileyen olgular olup, IgE aracılı olmayan hasta grubuna dahil edildi. Kontrol grubuna 0-36 ay arası, 24 sağlam çocuk alındı. Hasta ve kontrol grubuna tam kan sayımı, total IgE, serum TNF-?, IL-6, IL-10 ve DK çalışıldı. Hasta grubunda, tedavi uygulandıktan 4 hafta sonra TNF-?, IL-6, IL-10 ve DK tekrarlandı.Bulgular: Hasta grubunda TÖ DK, kontrol grubuna göre yüksek bulundu (p=0.024). IgE aracılı grupta TÖ serum IL-6, IgE aracılı olmayan gruba ve kontrol grubuna göre yüksek bulundu (p değeri sırasıyla 0.021 ve 0.027). Hasta grubunda ve IgE aracılı grupta, TS serum TNF-?, IL-6 ve DK, TÖ serum TNF-?, IL-6 ve DK'ye göre düşüş gösterdi (p değeri sırasıyla hasta grubu için; 0.005, 0.018

Published
2013

5. [Management and treatment difficulties of multi-drug resistant pulmonary tuberculosis in a pediatric case].

Author

Hançerli Törün S, Acar EM, Somer A, Erköse G, Şatana D, Bayramoğlu Z, Çalışkan E, and Kılıçaslan Z

Subjects
Adult, Female, Humans, Infant, Isoniazid pharmacology, Isoniazid therapeutic use, Pyrazinamide pharmacology, Pyrazinamide therapeutic use, Rifampin pharmacology, Rifampin therapeutic use, Treatment Outcome, Antitubercular Agents pharmacology, Antitubercular Agents therapeutic use, Mycobacterium tuberculosis drug effects, Tuberculosis, Multidrug-Resistant drug therapy, Tuberculosis, Pulmonary drug therapy
Abstract

Tuberculosis continues to be a major health problem worldwide. Multidrug resistant tuberculosis (MDR-TB) infection that occurs in childhood is caused by adult MDR-TB agents which are in circulation and resistant to primary drugs. In this case report a 17-month-old child with MDR-TB who was cured after a 24-month therapy regimen was presented. Physical examination of a 17-month-old girl admitted to the hospital with the cause of recurrent pneumonia revealed a rubbery lymphadenopathy less than 2 cm in the right upper cervical region. Crepitant rales were detected in the right basal on auscultation of the lung. Interferon gamma release assay (IGRA) and tuberculin skin (TST) tests were negative. Computed tomography (CT) scan of the chest showed mediastinal conglomerate pathologic lymphadenopathy and air bronchograms were detected near the lower lobe of the left lung. Treatment of isoniazid, rifampicin, pyrazinamide with the diagnosis of epituberculosis was started by taking a sample of gastric aspirate culture sample. In the sixth month of the treatment patient was admitted to our clinic with enlarged cervical rubbery lymphadenopathy. It was determined that microbiological test of gastric aspirate culture specimen was positive for M.tuberculosis complex resistant to isoniazid, rifampin, ethambutol, streptomycin, ethionamide and rifabutin. Control CT showed residual peribronchial infiltrations and hilar calcific lymph nodes. Hearing test, vision control and, thyroid function tests were performed and treatment of moxifloxacin, amikacin, para-amino salicylic acid, protionamide and pyrazinamide was started based on minor drug susceptibility results of M.tuberculosis isolate which was still growing in gastric aspirate culture. Gastric aspirate culture for M.tuberculosis was still positive after 3 months of treatment and the current treatment was continued. Amikacin was stopped after 6 months. Therapy regimen was stopped after 24-months. Over the course of a follow-up period of more than 3 years, the clinical and radiological resultsof the patient has improved significantly. The clinical presentation of TB in children is often nonspecific and differs from the patterns seen in adults. MDR-TB cases can be seen in this age group since tuberculosis in children is mainly caused by transmission of drug-resistant strains from adults. This situation is particularly problematic due to the long-term treatment and the lack of specific drug formulations for children.

Published
2018
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