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Abstract Fox nut (Euryale ferox) is categorized among superior quality foods because of its highly nutritious profile. It also serves as a good protein source for vegetarian diets. However, it is not widely consumed, due to soggy texture and bland flavor as compared to other nuts. In this study, we used roasting and seasoning to enhance its consumer acceptance. Furthermore, we have also compared biochemical, nutritional and physical properties of the roasted and unroasted fox nuts; and their Glycemic Index (GI) in human subjects. Results showed that roasting significantly (P ≤ 0.05) improved the minerals content (from 0.58 to 0.66%), protein content (from 11.40 to 14.57%), total phenolics (from 346.02 to 470.62 mg GAE/100 g), flavonoids (from 4.15 to 4.43 mg CE/g), 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity (from 48.54 to 79.13% inhibition) and Ferric Reducing Antioxidant Power (from 662.46 to 957.14 μmol FeSO4/g). Consumer acceptance was evaluated with and without seasoning; both salt and spice seasoned roasted nuts had greater overall acceptability as compared to plain roasted and unroasted nuts. Fox nuts also reported low GI (37%) in human subjects (ethical approval #1772/01-06-2020). Thus, roasted fox nuts can be consumed as nutrient rich and low GI snack; not only as a component of healthy diet but can also be served to patients with metabolic disorders like obesity and diabetes.

Bioelectronic medicine (BEM) is a relatively recent strategy towards discovering novel neuromodulation therapeutics for diseases that have traditionally been addressed with pharmaceuticals. Bioelectronic therapies are conceived as programmable implants that use closed-loop (CL) activation of neurons that regulate autonomic processes to address damaged autonomic responses. Such technologies are intended to track markers of the intended activity and, if a malfunction is detected, send modulatory signals to the embedded system of nerves to restore the activity to standard. The peripheral nerve system (PNS) has a great deal of potential for therapeutic treatment and regaining bodily functioning. Autonomic nerves have recently gained much attention because they govern a wide range of processes engaged in organ homeostasis and chronic condition, and they look tractable to specific regulation of single nerve unit. Ongoing pre-clinical researches have eliminated current constraints by identifying the anatomical targets, discovering novel neural technology and devising effective signal processing algorithms. In this way, the most significant clinical outcomes have been achieved by various BEM methods and the challenges of neuro-modulatory treatments have shown promising results. The existing state of knowledge and future prospects for clinical uses of neural decoding and ANS stimulation are summarized below in this study. Additionally, how the advances got translated into clinical settings have been investigated from retrospective studies and presented herewith. [ABSTRACT FROM AUTHOR]