1. The effects of systemic hormonal replacement therapy on the skin of postmenopausal women
- Author
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Paulo Hilário Nascimento Saldiva, Vicente Renato Bagnoli, A.V.D. Sauerbronn, Angela Maggio da Fonseca, and J.A. Pinotti
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Urology ,Placebo ,law.invention ,chemistry.chemical_compound ,Double-Blind Method ,Randomized controlled trial ,law ,Internal medicine ,Humans ,Medicine ,Prospective Studies ,Cyproterone Acetate ,Prospective cohort study ,Skin ,Chemotherapy ,Estradiol ,Progesterone Congeners ,medicine.diagnostic_test ,business.industry ,Estrogen Replacement Therapy ,Obstetrics and Gynecology ,Cyproterone acetate ,General Medicine ,Middle Aged ,medicine.disease ,Postmenopause ,Menopause ,Endocrinology ,chemistry ,Skin biopsy ,Female ,Collagen ,business ,Hormone - Abstract
Objective: The aim of this study was to determine the effects of hormonal replacement therapy on the skin of postmenopausal women. Method: Forty-one postmenopausal women were randomly allocated to receive either hormonal replacement (valerate estradiol — 2 mg/day for 21 days and cyproterone acetate — 1 mg/day for 10 days) or placebo, both in a cyclic scheme for 6 months. Neither patients nor investigators were aware of the group allocation. Histologic changes were evaluated by skin biopsy of the left upper arm at baseline and after 6 months of treatment, utilizing computerized image analysis to assess the ratio area of epidermis/basement membrane length (AE/BML), ratio area of keratin/basement membrane length (AK/BML) and collagen and elastic fibers content. Result: Collagen content of the left upper arm increased after 6 months of treatment only in the hormonal group (+6.49%; P
- Published
- 1999