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The study proposes a novel machine learning (ML) paradigm for cardiovascular disease (CVD) detection in individuals at medium to high cardiovascular risk using data from a Greek cohort of 542 individuals with rheumatoid arthritis, or diabetes mellitus, and/or arterial hypertension, using conventional or office-based, laboratory-based blood biomarkers and carotid/femoral ultrasound image-based phenotypes. Two kinds of data (CVD risk factors and presence of CVD—defined as stroke, or myocardial infarction, or coronary artery syndrome, or peripheral artery disease, or coronary heart disease) as ground truth, were collected at two-time points: (i) at visit 1 and (ii) at visit 2 after 3 years. The CVD risk factors were divided into three clusters (conventional or office-based, laboratory-based blood biomarkers, carotid ultrasound image-based phenotypes) to study their effect on the ML classifiers. Three kinds of ML classifiers (Random Forest, Support Vector Machine, and Linear Discriminant Analysis) were applied in a two-fold cross-validation framework using the data augmented by synthetic minority over-sampling technique (SMOTE) strategy. The performance of the ML classifiers was recorded. In this cohort with overall 46 CVD risk factors (covariates) implemented in an online cardiovascular framework, that requires calculation time less than 1 s per patient, a mean accuracy and area-under-the-curve (AUC) of 98.40% and 0.98 (p < 0.0001) for CVD presence detection at visit 1, and 98.39% and 0.98 (p < 0.0001) at visit 2, respectively. The performance of the cardiovascular framework was significantly better than the classical CVD risk score. The ML paradigm proved to be powerful for CVD prediction in individuals at medium to high cardiovascular risk. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

11 pages, 10 figures.-- PACS nrs.: 25.60.Dz, 25.60.Gc, 25.60.Bx, 21.10.Gv, 27.20.+n.-- 2nd version of the pre-print: Submitted on 18 Jul 2005 (v1), last revised 17 Nov 2005 (this version, v2), minor corrections made.-- Published in: Nuclear Physics A, Vol.765, Issues 3-4, pages 294-306 (6 February 2006).-- et al., Quasi-elastic scattering of 6He at E_lab=27 MeV from 197Au has been measured in the angular range of 6-72 degrees in the laboratory system employing LEDA and LAMP detection systems. These data, along with previously analysed data of 6He + 208Pb at the same energy, are analyzed using Optical Model calculations. The role of Coulomb dipole polarizability has been investigated. Large imaginary diffuseness parameters are required to fit the data. This result is an evidence for long range absorption mechanisms in 6He induced reactions., The authors thank the staff at the Cyclotron Research Centre accelerator facility in Louvain-la-Neuve, Belgium, for providing us with an intense and good quality radioactive beam. ORK acknowledges a grant from the Iranian government and support from the University of Sevilla for his stay at this university. PJW, TD, ACS, AL, ADP and WBS would like to acknowledge support from the British EPSRC. AMSB, IMB, MVA, AM, MAGA and JGC would like to acknowledge support from the Spanish MCyT under projects FPA2003-05958 and FPA2005-04460. AMSB acknowledges a research grant from the Spanish MCyT.

Elastic scattering of He-6 at E-lab = 27 MeV with Pb-208 has been measured in the angular range of 6degrees-72degrees in the laboratory system employing LEDA and LAMP detection systems. Optical Model calculations have been performed using dynamic polarisation potential. The role of Coulomb dipole polarisability has been investigated. Large values of the imaginary diffuseness parameter are required in order to fit the data. (C) 2003 Elsevier B.V. All rights reserved.

Transfer reactions are verified to be an important tool for the study of light unbound nuclei. We have studied the proton-rich unbound nuclei 15 F and 11 N, 10 N respectively through the 16 O( 14 N, 15 C) 15 F and 12 C( 14 N, 15 C) 11 N, 10 B( 14 N, 13 B) 11 N, 10 B( 14 N, 14 B) 10 N reactions. Resonance energies and width were obtained.

In order to obtain information on a possible two-neutron component in the 6He wavefunction, we investigated the 4He( 6He, 6He) 4He elastic scattering at beam energies of 29.1, 29.6 and 40 MeV and at center-of-mass angles between 20 and 163 degrees. The experiments were performed at the ARENAS Radioactive Ion Beam Facility in Louvain-La-Neuve. We used a 4He-implanted aluminium foil as a target. A 4He thickness of about 2-3 * 10 17 particlescm 2 was obtained implanting 4He nuclei at energies between 20 and 80 keV in 0.7- mu m-thick foils. Data collected in a larger angular range than previous measurements give additional evidence for the 2n-transfer process to take place in the 4He( 6He, 6He) 4He scattering. Our results demonstrate the possibility of using a 4He-implanted target in experiments with low-intensity beams, like radioactive beams, where deterioration of the target is irrelevant.

We discuss the design and implementation of the Louvain-Edinburgh Detector Array: a charged particle detector array composed of silicon-strip detectors which is used for the study of nuclear astrophysics and nuclear physics using radioactive nuclear beams at the Louvain-1a-Neuve radioactive nuclear beam facility. (C) 2000 Elsevier Science B.V. All rights reserved.

The ground state of the proton-rich, unbound nucleus ${}^{11}\mathrm{N}$ was observed, together with six excited states using the multinucleon transfer reaction ${}^{10}\mathrm{B}{(}^{14}\mathrm{N}{,}^{13}\mathrm{B}{)}^{11}\mathrm{N}$ at $30A$ MeV incident energy at Grand Acc\'el\'erateur National d'Ions Lourds. Levels of ${}^{11}\mathrm{N}$ are observed as well defined resonances in the spectrum of the ${}^{13}\mathrm{B}$ ejectiles. They are localized at 1.63(5), 2.16(5), 3.06(8), 3.61(5), 4.33(5), 5.98(10), and 6.54(10) MeV above the ${}^{10}\mathrm{C}+p$ threshold. The ground-state resonance has a mass excess of 24.618(50) MeV; the experimental width is smaller than theoretical predictions.

The elastic scattering He-4(He-6,He-6)He-4 has been investigated at center-of-mass energies of 11.6 and 15.9 MeV. Differential cross sections are determined using a post-accelerated He-6 (T-1/2 = 0.807 s) beam in the center-of-mass angular range between 50 and 140 degrees. The comparison of the measured data with calculations using a double folding potential shows evidence for the 2n-transfer process in the He-4(He-6,He-6)He-4 elastic scattering. (C) 1999 Published by Elsevier Science B.V, All rights reserved.

The reaction Ne-18(alpha, p)Na-21, of importance to nuclear astrophysics, has been studied directly using the postaccelerated radioactive Ne-18 beam available at Louvain-la-Neuve and a gaseous helium target. This: study covered the energy region from 2.04 to 3.01 MeV in the center of mass, and identified various levels in the compound nucleus Mg-22. The stellar reaction rate due to these states has been deduced. The experimental rate shows good agreement with theoretical predictions [J. Gorres, M. Wiescher, and F. K. Thielemann, Phys. Rev. C 51, 392 (1995)] above 2.5 GK. [S0556-2813(99)02906-4].

Reactions such as 18 Ne(α, p) 21 Na of importance to Nuclear Astrophysics may be studied directly through the use of a radioactive beam and a gaseous helium target. A system to study such reactions has been developed and tested using the 13 N beam available at the Radioactive Ion Beam facility (RIB) at Louvain-la-Neuve. This ( α , p ) reaction was chosen as previous studies of the inverse reaction 16 O(p, α) 13 N allowed the resonance strength of a strong resonance at 8.07 MeV (Tilley et al., Nucl. Phys. A 564 (1993) 139) in the compound nucleus 17 F to be calculated and compared with that obtained through experiment. These resonance strengths showed good agreement and so validated the technique for further work.

The He-6 + He-4 elastic scattering cross section was measured at E-c.m.=11.6 MeV using a He-6 radioactive beam and a He-4-implanted Al foil as target. The use of the thin implanted target allowed to enlarge the angular range in which the data were collected, with respect to a previous measurement at the same center-of-mass energy. The new and previous data are compared with several calculations. The inclusion of a description for the 2n-transfer process, either with a parity-dependent term, or with a distorted-wave Born approximation transfer amplitude, is crucial to reproduce the increase of the cross section at large angles, thus assessing the contribution of the 2n-transfer process to the reaction. At the present energy, the complicated nature of the transfer process and the possible role played by the coupling to other channels, in particular, the breakup, require sophisticated reaction models in order to extract the relevant information on the peculiar He-6 nucleus. The quality of the data is such that the differences between He-6 and the similar Li-6 system should be identified by such calculations.

Neutron‐deficient nuclei with Tz equals to −3/2 and −2 have been produced at the GANIL/LISE3 facility in fragmentation reactions of a 95 MeV/u 36Ar primary beam in a 12C target. For the first time, β‐delayed proton and β‐γ emission has been simultaneously observed in the decay of 21Mg, 25Si and 26P. The decay scheme of the latter is proposed and the Gamow‐Teller strength distribution in its β decay is compared to shell‐model calculations based on the USD interaction. The B(GT) values derived from the absolute measurement of the β‐branching ratios are in agreement with the quenching factor of about 60% obtained for allowed Gamow‐Teller transitions in this mass region. A precise half‐life of 43.7 (6) ms was determined for 26P, the β‐2p emission of which was studied. The expected contribution of spectroscopic studies of neutron‐rich nuclei is discussed with respect to the mirror asymmetry phenomenon occuring in analogous β decays.

The 15O(α,γ)19Ne reaction is generally considered as a potential breakout reaction from the hot CNO cycle. Under nova conditions, the reaction rate is dominated by a single sub-Coulomb resonance at Ec.m.=504 keV which corresponds to a 19Ne excitation energy of ER=4.033 MeV. Results from a d(18Ne,19Ne)p experiment show that states of astrophysical interest are populated in this reaction. An upper limit for the α-branching ratio of the 4.033 MeV state was identified and branching ratios for other states in 19Ne were found to be in good agreement with stable beam based results.

For the first time evidence of the ground state of the proton-rich, unbound nucleus ${}^{10}\mathrm{N}$ has been found in the multinucleon transfer reaction ${}^{10}\mathrm{B}{(}^{14}\mathrm{N}{,}^{14}\mathrm{B}{)}^{10}\mathrm{N}.$ The observed resonance of ${}^{10}\mathrm{N}$ has a mass excess of 38.8(4) MeV and a width of $\ensuremath{\Gamma}=2.3(16) \mathrm{MeV},$ close to the Audi-Wapstra estimation of 38.5(4) MeV. ${}^{10}\mathrm{N}$ is the last missing $A=10$ multiplet partner.

The 15 O( α , γ ) 19 Ne reaction is generally considered as the potential breakout reaction from the hot-CNO cycle. Under nova conditions, the reaction depends dominantly on a single sub-Coulomb resonance at E c.m. =504 keV which corresponds to a 19 Ne excitation energy of E R =4.033 MeV. It is possible to model the 15 O( α , γ ) 19 Ne reaction rate, if the branching ratio Γ α / Γ and the total resonance width Γ of this state are known. Results from an exploratory 18 Ne(d,p) experiment performed in inverse kinematics at E lab =44.1 MeV and 10 6 pps beam intensity show that the 4.033 MeV state—among other resonances of astrophysical interest—is populated in this reaction ( d σ/ d Ω=0.5±0.2 mb / sr at θ lab =138°). The determination of Γ α / Γ =0.28±0.13 for another 19 Ne resonance at E R =4.600 MeV found to be in good agreement with a stable beam based result shows the feasibility of this radioactive nuclear beam based approach provided that higher 18 Ne beam intensities become available.

Low-energy post-accelerated radioactive ion beams have been used to study nuclear reactions addressing important nuclear structure and nuclear astrophysics questions. A high-granularity, large-solid-angle silicon strip detector array has been used to account for the low reaction products' yields. First experiments using a He-6 beam on thin C-12 targets show the feasibility of direct reaction studies with good angular resolution and a detection limit in access of 0.1 mb sr(-1) cross sections. The measurement of the six alpha-decay channel in a N-13-induced reaction on a B-11 target shows the capabilities of this experimental technique even for sophisticated reaction studies. The study of stellar properties in ground-based experiments, in particular break-out reactions from the hot-CNO, i.e. O-15(alpha, gamma) Ne-19, can be pursued using these beams. Experiments are being performed to study these reactions by measurement of d(Ne-18, p) Ne-19*(alpha)O-15 and alpha(Ne-18, p), which might provide an alternative breakout route.