24,197 results on '"A. Zinn."'
Search Results
2. Testing the Breakdown of the Asteroseismic Scaling Relations in Luminous Red Giants
- Author
-
Ash, Amanda L., Pinsonneault, Marc H., Vrard, Mathieu, and Zinn, Joel
- Subjects
Astrophysics - Solar and Stellar Astrophysics - Abstract
Nearly all cool, evolved stars are solar-like oscillators, and fundamental stellar properties can be inferred from these oscillations with asteroseismology. Scaling relations are commonly used to relate global asteroseismic properties, the frequency of maximum power $\nu_{max}$ and the large frequency separation $\Delta \nu$, to stellar properties. Mass, radius, and age can then be inferred with the addition of stellar spectroscopy. There is excellent agreement between seismic radii and fundamental data on the lower red giant branch and red clump. However, the scaling relations appear to breakdown in luminous red giant stars. We attempt to constrain the contributions of the asteroseismic parameters to the observed breakdown. We test the $\nu_{max}$ and $\Delta \nu$ scaling relations separately, by using stars of known mass and radius in star clusters and the Milky Way's high-$\alpha$ sequence. We find evidence that the $\Delta \nu$-scaling relation contributes to the observed breakdown in luminous giants more than the $\nu_{max}$ relation. We test different methods of mapping the observed $\Delta \nu$ to the mean density via a correction factor, $F_{\Delta \nu}$ and find a $\approx 1 - 3\%$ difference in the radii in the luminous giant regime depending on the technique used to measure $F_{\Delta \nu}$. The differences between the radii inferred by these two techniques are too small on the luminous giant branch to account for the inflated seismic radii observed in evolved giant stars. Finally, we find that the $F_{\Delta \nu}$ correction is insensitive to the adopted mixing length, chosen by calibrating the models to observations of $T_{eff}$., Comment: 28 pages, 15 figures, and 5 tables in text. 4 additional pages in the appendix. Submitted to ApJ
- Published
- 2024
3. APOKASC-3: The Third Joint Spectroscopic and Asteroseismic catalog for Evolved Stars in the Kepler Fields
- Author
-
Pinsonneault, Marc H., Zinn, Joel C., Tayar, Jamie, Serenelli, Aldo, Garcia, Rafael A., Mathur, Savita, Vrard, Mathieu, Elsworth, Yvonne P., Mosser, Benoit, Stello, Dennis, Bell, Keaton J., Bugnet, Lisa, Corsaro, Enrico, Gaulme, Patrick, Hekker, Saskia, Hon, Marc, Huber, Daniel, Kallinger, Thomas, Cao, Kaili, Johnson, Jennifer A., Liagre, Bastien, Patton, Rachel A., Santos, Angela R. G., Basu, Sarbani, Beck, Paul G., Beers, Timothy C., Chaplin, William J., Cunha, Katia, Frinchaboy, Peter M., Girardi, Leo, Godoy-Rivera, Diego, Holtzman, Jon A., Jonsson, Henrik, Meszaros, Szabolcs, Reyes, Claudia, Rix, Hans-Walter, Shetrone, Matthew, Smith, Verne V., Spoo, Taylor, Stassun, Keivan G., and Wang, Ji
- Subjects
Astrophysics - Solar and Stellar Astrophysics - Abstract
In the third APOKASC catalog, we present data for the complete sample of 15,808 evolved stars with APOGEE spectroscopic parameters and Kepler asteroseismology. We used ten independent asteroseismic analysis techniques and anchor our system on fundamental radii derived from Gaia $L$ and spectroscopic $T_{\rm eff}$. We provide evolutionary state, asteroseismic surface gravity, mass, radius, age, and the spectroscopic and asteroseismic measurements used to derive them for 12,418 stars. This includes 10,036 exceptionally precise measurements, with median fractional uncertainties in \nmax, \dnu, mass, radius and age of 0.6\%, 0.6\%, 3.8\%, 1.8\%, and 11.1\% respectively. We provide more limited data for 1,624 additional stars which either have lower quality data or are outside of our primary calibration domain. Using lower red giant branch (RGB) stars, we find a median age for the chemical thick disk of $9.14 \pm 0.05 ({\rm ran}) \pm 0.9 ({\rm sys})$ Gyr with an age dispersion of 1.1 Gyr, consistent with our error model. We calibrate our red clump (RC) mass loss to derive an age consistent with the lower RGB and provide asymptotic GB and RGB ages for luminous stars. We also find a sharp upper age boundary in the chemical thin disk. We find that scaling relations are precise and accurate on the lower RGB and RC, but they become more model dependent for more luminous giants and break down at the tip of the RGB. We recommend the usage of multiple methods, calibration to a fundamental scale, and the usage of stellar models to interpret frequency spacings., Comment: 43 pages, 25 figures, submitted ApJSupp. Comments welcome. Data tables available on request from pinsonneault.1@osu.edu
- Published
- 2024
4. Stellar Models are Reliable at Low Metallicity: An Asteroseismic Age for the Ancient Very Metal-Poor Star KIC 8144907
- Author
-
Huber, Daniel, Slumstrup, Ditte, Hon, Marc, Li, Yaguang, Borsen-Koch, Victor Aguirre, Bedding, Timothy R., Joyce, Meridith, Ong, J. M. Joel, Serenelli, Aldo, Stello, Dennis, Berger, Travis, Grunblatt, Samuel K., Greklek-McKeon, Michael, Hirano, Teruyuki, Kirby, Evan N., Pinsonneault, Marc H., Puls, Arthur Alencastro, and Zinn, Joel
- Subjects
Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
Very metal-poor stars ([Fe/H]<-2) are important laboratories for testing stellar models and reconstructing the formation history of our galaxy. Asteroseismology is a powerful tool to probe stellar interiors and measure ages, but few asteroseismic detections are known in very metal-poor stars and none have allowed detailed modeling of oscillation frequencies. We report the discovery of a low-luminosity Kepler red giant (KIC 8144907) with high S/N oscillations, [Fe/H]=-2.66+/-0.08 and [alpha/Fe]=0.38+/-0.06, making it by far the most metal-poor star to date for which detailed asteroseismic modeling is possible. By combining the oscillation spectrum from Kepler with high-resolution spectroscopy we measure an asteroseismic mass and age of 0.79+/-0.02(ran)+/-0.01(sys) Msun and 12.0+/-0.6(ran)+/-0.4(sys) Gyr, with remarkable agreement across different codes and input physics, demonstrating that stellar models and asteroseismology are reliable for very metal-poor stars when individual frequencies are used. The results also provide a direct age anchor for the early formation of the Milky Way, implying that substantial star formation did not commence until redshift z~3 (if the star formed in-situ) or that the Milky Way has undergone merger events for at least ~12 Gyr (if the star was accreted by a dwarf satellite merger such as Gaia Enceladus)., Comment: 10 pages, 4 figures, accepted for publication in ApJ
- Published
- 2024
5. Bacillary hemoglobinuria in beef cattle infected with Fascioloides magna in Missouri.
- Author
-
Ierardi, Rosalie, Burnum, Annabelle, Camp, Lauren, Delaney, Lauren, Gull, Tamara, Havis, Brett, Johnson, Gayle, Kim, Dae, Kuroki, Kei, Mammone, Renata, Mitchell, William, Navarro, Mauricio, Rivero, Luis, Shapiro, Karen, Smith, Amanda, Valerio, Courtney, Williams, Fred, Zinn, Michael, and Uzal, Francisco
- Subjects
Clostridium haemolyticum ,Clostridium novyi ,Fascioloides magna ,bacillary hemoglobinuria ,cattle ,clostridial hepatitis ,fluke ,hemoglobinuria - Abstract
Bacillary hemoglobinuria (BH) is an infectious disease, mostly affecting cattle, caused by Clostridium haemolyticum (C. novyi type D), with acute hepatic necrosis and intravascular hemolysis. Cattle are typically predisposed to BH by liver injury caused by Fasciola hepatica, although cases have been reported in cattle without evidence of this parasite. Here we describe a cluster of 14 BH cases from 7 counties in north-central to central Missouri submitted to a veterinary diagnostic laboratory between December 2020 and April 2023. Postmortem examination in all cases revealed hemoglobinuria and acute hepatic necrosis with large numbers of gram-positive bacilli with terminal-to-subterminal spores. Flukes, fluke ova, and/or fluke pigment consistent with Fascioloides magna were identified in 12 of 14 cases. Sequences of the nuclear ribosomal internal transcribed spacer 1 (ITS1) from one fluke had 100% identity to F. magna. C. novyi was detected by fluorescent antibody testing of liver impression smears (11 of 12 cases) and by immunohistochemistry of liver sections (7 of 7 cases). PCR on formalin-fixed, paraffin-embedded tissues amplified the C. haemolyticum beta toxin gene in each of the 7 cases tested. To our knowledge, a confirmed cluster of BH associated with F. magna has not been reported previously in cattle.
- Published
- 2024
6. A uniform trigonometric R-matrix for the exceptional series
- Author
-
Westbury, Bruce W. and Zinn-Justin, Paul
- Subjects
Mathematics - Representation Theory ,Mathematical Physics ,Mathematics - Quantum Algebra - Abstract
We give a uniform trigonometric $R$-matrix for the adjoint representations on the exceptional series. The exceptional series is a finite list of points on a projective line with a simple Lie algebra attached to each point. This list of Lie algebras includes the five exceptional Lie algebras. For $L$ a simple Lie algebra there is a rational $R$-matrix in $\mathrm{End}_L(\otimes^2(L\oplus I))$ which has a quantum deformation to a trigonometric $R$-matrix. We construct a sixteen dimensional algebra, $A^\square(\mathit{2})$, which interpolates the quantum deformations of the algebras $\mathrm{End}_L(\otimes^2(L\oplus I))$ and a 287 dimensional algebra, $A^\square(\mathit{3})$, which interpolates the quantum deformations of the algebras $\mathrm{End}_L(\otimes^3(L\oplus I))$. Then we construct an $R$-matrix in $A^\square(\mathit{2})$ which satisfies the Yang--Baxter equation in $A^\square(\mathit{3})$ and which interpolates the trigonometric $R$-matrices for the points in the exceptional series.
- Published
- 2024
7. Instantons in $\phi^4$ Theories: Transseries, Virial Theorems and Numerical Aspects
- Author
-
Giorgini, Ludovico T., Jentschura, Ulrich D., Malatesta, Enrico M., Rizzo, Tommaso, and Zinn-Justin, Jean
- Subjects
High Energy Physics - Theory - Abstract
We discuss numerical aspects of instantons in two- and three-dimensional $\phi^4$ theories with an internal $O(N)$ symmetry group, the so-called $N$-vector model. Combining asymptotic transseries expansions for large argument with convergence acceleration techniques, we obtain high-precision values for certain integrals of the instanton that naturally occur in loop corrections around instanton configurations. Knowledge of these numerical properties are necessary in order to evaluate corrections to the large-order factorial growth of perturbation theory in $\phi^4$ theories. The results contribute to the understanding of the mathematical structures underlying the instanton configurations., Comment: 11 pages; RevTeX
- Published
- 2024
- Full Text
- View/download PDF
8. Integrability and combinatorics
- Author
-
Zinn-Justin, Paul
- Subjects
Mathematics - Combinatorics ,Mathematical Physics - Abstract
We discuss the use of methods coming from integrable systems to study problems of enumerative and algebraic combinatorics, and develop two examples: the enumeration of Alternating Sign Matrices and related combinatorial objects, and the theory of symmetric polynomials., Comment: review article for the Encyclopedia of Mathematical Physics 2nd edition
- Published
- 2024
9. A case series and review of stereotactic body radiation therapy for contiguous multilevel spine metastases
- Author
-
Adida, Samuel, Taori, Suchet, Bhatia, Shovan, Kann, Michael R., Burton, Steven A., Flickinger, John C., Olson, Adam C., Sefcik, Roberta K., Zinn, Pascal O., and Gerszten, Peter C.
- Published
- 2024
- Full Text
- View/download PDF
10. Information entropy facilitates (not impedes) lexical processing during language comprehension
- Author
-
Karimi, Hossein, Weber, Pete, and Zinn, Jaden
- Published
- 2024
- Full Text
- View/download PDF
11. Floral Ethics and Aesthetics: Understanding Professional Expertise at Work
- Author
-
Zinn, Isabelle
- Published
- 2024
- Full Text
- View/download PDF
12. Higher spin representations of the Yangian of $\mathfrak{sl}_2$ and R-matrices
- Author
-
Yang, Yaping and Zinn-Justin, Paul
- Subjects
Mathematics - Representation Theory ,Mathematical Physics ,Mathematics - Algebraic Geometry ,Primary 17B37, Secondary 55N22, 16G20 - Abstract
We study higher spin (pure and mixed spin) representations of the Yangian of $\mathfrak{sl}_2$. We provide a geometric realization in terms of the critical cohomology of representations of the quiver with potential of Bykov and Zinn-Justin [BZJ20]. When the framing dimension is 1, it recovers the evaluation pullback of the $\ell+1$-dimensional irreducible representation of $\mathfrak{sl}_2$. We introduce the lattice model and prove that its partition function coincides with the weight function constructed using the framed shuffle formula. The latter follows the approach of Rim\'anyi, Tarasov and Varchenko [RTV15].
- Published
- 2024
13. The APO-K2 Catalog. II. Accurate Stellar Ages for Red Giant Branch Stars across the Milky Way
- Author
-
Warfield, Jack T., Zinn, Joel C., Schonhut-Stasik, Jessica, Johnson, James W., Pinsonneault, Marc H., Johnson, Jennifer A., Stello, Dennis, Beaton, Rachael L., Elsworth, Yvonne, García, Rafael A., Mathur, Savita, Mosser, Benoît, Serenelli, Aldo, and Tayar, Jamie
- Subjects
Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
We present stellar age determinations for 4661 red giant branch stars in the APO-K2 catalog, derived using mass estimates from K2 asteroseismology from the K2 Galactic Archaeology Program and elemental abundances from the Apache Point Galactic Evolution Experiment survey. Our sample includes 17 of the 19 fields observed by K2, making it one of the most comprehensive catalogs of accurate stellar ages across the Galaxy in terms of the wide range of populations spanned by its stars, enabling rigorous tests of Galactic chemical evolution models. Taking into account the selection functions of the K2 sample, the data appear to support the age-chemistry morphology of stellar populations predicted by both inside-out and late-burst scenarios. We also investigate trends in age versus stellar chemistry and Galactic position, which are consistent with previous findings. Comparisons against APOKASC-3 asteroseismic ages show agreement to within ~3%. We also discuss offsets between our ages and spectroscopic ages. Finally, we note that ignoring the effects of $\alpha$-enhancement on stellar opacity (either directly or with the Salaris metallicity correction) results in an ~10% offset in age estimates for the most $\alpha$-enhanced stars, which is an important consideration for continued tests of Galactic models with this and other asteroseismic age samples.
- Published
- 2024
- Full Text
- View/download PDF
14. Nature vs. Nurture: Distinguishing Effects from Stellar Processing and Chemical Evolution on Carbon and Nitrogen in Red Giant Stars
- Author
-
Roberts, John D., Pinsonneault, Marc H., Johnson, Jennifer A., Zinn, Joel C., Weinberg, David H., Vrard, Mathieu, Tayar, Jamie, Stello, Dennis, Mosser, Benoît, Johnson, James W., Cao, Kaili, Stassun, Keivan G., Stringfellow, Guy S., Serenelli, Aldo, Mathur, Savita, Hekker, Saskia, García, Rafael A., Elsworth, Yvonne P., and Corsaro, Enrico
- Subjects
Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
The surface [C/N] ratios of evolved giants are strongly affected by the first dredge-up (FDU) of nuclear-processed material from stellar cores. C and N also have distinct nucleosynthetic origins and serve as diagnostics of mixing and mass loss. We use subgiants to find strong trends in the birth [C/N] with [Fe/H], which differ between the low-$\alpha$ and high-$\alpha$ populations. We demonstrate that these birth trends have a strong impact on the surface abundances after the FDU. This effect is neglected in current stellar models, which use solar-scaled C and N. We map out the FDU as a function of evolutionary state, mass, and composition using a large and precisely measured asteroseismic dataset in first-ascent red giant branch (RGB) and core He-burning, or red clump (RC), stars. We describe the domains where [C/N] is a useful mass diagnostic and find that the RC complements the RGB and extends the range of validity to higher mass. We find evidence for extra mixing on the RGB below [Fe/H]= -0.4, matching literature results, for high-$\alpha$ giants, but there is no clear evidence of mixing in the low-$\alpha$ giants. The predicted signal of mass loss is weak and difficult to detect in our sample. We discuss implications for stellar physics and stellar population applications., Comment: 19 pages, 19 figures
- Published
- 2024
15. La Silla-QUEST RR Lyrae Star Survey II: The Crater II Tidal Streams
- Author
-
Coppi, P. S., Zinn, R., Baltay, C., Rabinowitz, D., Girard, T., Howard, R., Ment, K., and Rahman, R.
- Subjects
Astrophysics - Astrophysics of Galaxies ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We describe photometry improvements in the La Silla--Quest RR Lyrae star (RRLS) survey that enable it to reach distances from the Sun ($d_{\odot}$) $\sim 140$ kpc. We report the results of surveying $\sim 300~ {\rm deg}^2$ of sky around the large, low-surface-brightness Crater II dwarf spheroidal galaxy. At $d_{\odot}$ $> 80$ kpc, we find a large overdensity of RRLS that extends beyond the traditional isophotal contours used for Crater II. The majority of these RRLS (34) have a linear distribution on the sky, extending over $15^{\circ}$, that runs through Crater II and is oriented along Crater II's proper motion vector. We hypothesize that this unlikely distribution traces extended tidal streams associated with Crater II. To test this, we search for other Crater II stellar populations that should be in the streams. Using Gaia proper motion data, we isolate $\approx$ 17 candidate stars outside of Crater II that are consistent with being luminous stars from the Crater II Red Giant Branch (RGB). Their spatial distribution is consistent with the RRLS one. The inferred streams are long, spanning a distance range $\sim 80 - 135$ kpc from the Galactic Centre. They are oriented at a relatively small angle relative to our line-of-sight ($\sim 25^{\circ}$), which means some stream stars are likely projected onto the main body of the galaxy. Comparing the numbers of RRLS and RGB candidate stars found in the streams to those in the main galaxy, we estimate Crater II has lost $\gtrsim 30\%$ of its stellar mass., Comment: 29 pages, 19 figures, accepted for publication in Monthly Notices of the Royal Astronomical Society
- Published
- 2024
16. A System for Human-Robot Teaming through End-User Programming and Shared Autonomy
- Author
-
Hagenow, Michael, Senft, Emmanuel, Radwin, Robert, Gleicher, Michael, Zinn, Michael, and Mutlu, Bilge
- Subjects
Computer Science - Robotics - Abstract
Many industrial tasks-such as sanding, installing fasteners, and wire harnessing-are difficult to automate due to task complexity and variability. We instead investigate deploying robots in an assistive role for these tasks, where the robot assumes the physical task burden and the skilled worker provides both the high-level task planning and low-level feedback necessary to effectively complete the task. In this article, we describe the development of a system for flexible human-robot teaming that combines state-of-the-art methods in end-user programming and shared autonomy and its implementation in sanding applications. We demonstrate the use of the system in two types of sanding tasks, situated in aircraft manufacturing, that highlight two potential workflows within the human-robot teaming setup. We conclude by discussing challenges and opportunities in human-robot teaming identified during the development, application, and demonstration of our system., Comment: Proceedings of the 2024 ACM/IEEE International Conference on Human-Robot Interaction (HRI '24), March 11 - 14, 2024, Boulder, CO, USA
- Published
- 2024
- Full Text
- View/download PDF
17. Life Histories on Transforming the Study of Racism: An Introduction
- Author
-
Andersen, Margaret L., primary and Zinn, Maxine Baca, additional
- Published
- 2024
- Full Text
- View/download PDF
18. 13 Redefining and Reclaiming Race as a Latina Sociologist
- Author
-
Zinn, Maxine Baca, primary
- Published
- 2024
- Full Text
- View/download PDF
19. Influences of a Supplemental Blend of Essential Oils Plus 25-Hydroxy-Vit-D3 and Zilpaterol Hydrochloride (β2 Agonist) on Growth Performance and Carcass Measures of Feedlot Lambs Finished under Conditions of High Ambient Temperature.
- Author
-
Estrada-Angulo, Alfredo, Verdugo-Insúa, Moisés, Escobedo-Gallegos, Lucía, Castro-Pérez, Beatriz, Urías-Estrada, Jesús, Ponce-Barraza, Elizama, Mendoza-Cortez, Daniel, Ríos-Rincón, Francisco, Monge-Navarro, Francisco, Barreras, Alberto, Zinn, Richard, Corona-Gochi, Luis, and Plascencia, Alejandro
- Subjects
carcass ,energetics ,essential oils ,feedlot lambs ,growth performance ,zilpaterol chlorhydrate - Abstract
Forty-eight Pelibuey × Katahdin male intact lambs (25.12 ± 3.79 kg LW) were used in a 70-d growing-finishing trial. Dietary treatments consisted of total mixed corn-based diet supplemented with: (1) no feed additives (Control); (2) 150 mg of essential oils blend plus 0.10 mg of 25-hydroxy-Vit-D3/kg diet offered throughout the 70-d experimental period (EOD3); (3) Control diet fed during the first 35 days and zilpaterol hydrochloride (ZH) supplementation at 6 mg/kg diet offered during the final 35 days of the experiment (32 days with ZH with a withdrawal 3-d before harvest), and (4) basal diet supplemented with EOD3 during first 35 days finishing, and EOD3 in combination with ZH (EOD3 + ZH) during the subsequent 32-days with ZH withdrawal 3 days before harvest. The temperature-humidity index during the experiment averaged 80.4 ± 3.2. There were no treatment interactions (p > 0.20) on growth performance and carcass measures. Supplemental EOD3 did not affect (p = 0.43) dry matter intake (DMI), but increased (p < 0.01) carcass adjusted average daily gain (ADG, 9.2%), gain efficiency (GF, 6.7%), and observed vs. expected dietary net energy for maintenance (NEm, 4.8%) and for gain (NEg, 6.4%). Supplemental ZH did not affect dry matter intake (DMI, p = 0.50) but increased (p < 0.01) carcass adjusted ADG (14.5%), GF (13%) and observed vs. expected dietary NEm (9%) and NEg (11.7%). Compared to control lambs, the combination of both additives increased ADG (24.9%), GF (21.2%), and observed vs. expected dietary NEm and NEg (14.2% and 18.9%, respectively). There were no treatment interactions on carcass characteristics, visceral organ mass, or on gene expression of IGF1, IGF2 and mTOR in longissimus muscle (LM). Supplemental EOD3 increased hot carcass weight (HCW; 4.0%, p < 0.01) but did not affect other carcass measures. Supplemental EOD3 decreased (3%, p = 0.03) intestine mass weight (g intestine/kg empty body weight). Supplemental ZH increased HCW (6%, p < 0.01), dressing percentage (1.7%, p = 0.04), and LM area (9.7%, p < 0.01), and decreased kidney-pelvic-fat percentage (16.2%, p < 0.01), fat thickness (14.7%, p = 0.03), and visceral fat. Compared to controls, the combination of EOD3 with ZH increased HCW (10.2%). It is concluded that growth performance responses to supplemental EOD3 and ZH are additive. Both supplements can be fed in combination without detrimental effects on expected benefits when fed separately. In addition, ZH supplementation improves carcass traits.
- Published
- 2024
20. Confirmation of Skywalker Hoolock Gibbon (Hoolock tianxing) in Myanmar Extends Known Geographic Range of an Endangered Primate
- Author
-
Aung, Pyae Phyo, Lwin, Ngwe, Aung, Tin Htun, Htike, Thura Soe Min, Thompson, Carolyn, Roos, Christian, Zaw, Sa Myo, Lum, L. Zawng, Oo, Win Naing, Sau, Zung, Turvey, Samuel T., Thein, Wai Zinn, Maw, Min Thein, Win, Ye Tun, Oo, Zaw Min, Van Rompay, Koen K. A., Gilardi, Kirsten V., Tremeu-Bravard, Alex, Momberg, Frank, Fan, Peng-Fei, Cheyne, Susan M., and Smiley Evans, Tierra
- Published
- 2024
- Full Text
- View/download PDF
21. Microtube self-assembly leads to conformational freezing point depression
- Author
-
Komarova, Tatiana, Zinn, Thomas, Narayanan, Theyencheri, Petukhov, Andrei V., and Landman, Jasper
- Subjects
Condensed Matter - Soft Condensed Matter ,Physics - Chemical Physics - Abstract
Concentric microtubes of $\beta$-cyclodextrin and SDS grow from the outside in and melt from the inside out, we observe using in situ small angle X-ray scattering. We find that the conformation of the crystalline bilayer affects the saturation concentration, providing an example of a phenomenon we call conformational freezing point depression. We propose a model based on freezing point depression, well known from undergraduate physics, and use it to explain the energetics of this hierarchical system, and giving access to material properties without free parameters.
- Published
- 2023
22. [11C]Paraoxon: Radiosynthesis, Biodistribution and In Vivo Positron Emission Tomography Imaging in Rat.
- Author
-
Hayes, Thomas, Chao, Chih-Kai, Huynh, Tony, VanBrocklin, Henry, Zinn, Kurt, Gerdes, John, Thompson, Charles, and Blecha, Joseph
- Subjects
Rats ,Animals ,Paraoxon ,Tissue Distribution ,Acetylcholinesterase ,Positron-Emission Tomography ,Organophosphorus Compounds ,Carbon Radioisotopes - Abstract
Synthesis of the acetylcholinesterase inhibitor paraoxon (POX) as a carbon-11 positron emission tomography tracer ([11C]POX) and profiling in live rats is reported. Naïve rats intravenously injected with [11C]POX showed a rapid decrease in parent tracer to ∼1%, with an increase in radiolabeled serum proteins to 87% and red blood cells (RBCs) to 9%. Protein and RBC leveled over 60 minutes, reflecting covalent modification of proteins by [11C]POX. Ex vivo biodistribution and imaging profiles in naïve rats had the highest radioactivity levels in lung followed by heart and kidney, and brain and liver the lowest. Brain radioactivity levels were low but observed immediately after injection and persisted over the 60-minute experiment. This showed for the first time that even low POX exposures (∼200 ng tracer) can rapidly enter brain. Rats given an LD50 dose of nonradioactive paraoxon at the LD50 20 or 60 minutes prior to [11C]POX tracer revealed that protein pools were blocked. Blood radioactivity at 20 minutes was markedly lower than naïve levels due to rapid protein modification by nonradioactive POX; however, by 60 minutes the blood radioactivity returned to near naïve levels. Live rat tissue imaging-derived radioactivity values were 10%-37% of naïve levels in nonradioactive POX pretreated rats at 20 minutes, but by 60 minutes the area under the curve (AUC) values had recovered to 25%-80% of naïve. The live rat imaging supported blockade by nonradioactive POX pretreatment at 20 minutes and recovery of proteins by 60 minutes. SIGNIFICANCE STATEMENT: Paraoxon (POX) is an organophosphorus (OP) compound and a powerful prototype and substitute for OP chemical warfare agents (CWAs) such as sarin, VX, etc. To study the distribution and penetration of POX into the central nervous system (CNS) and other tissues, a positron emission tomography (PET) tracer analog, carbon-11-labeled paraoxon ([11C]POX), was prepared. Blood and tissue radioactivity levels in live rats demonstrated immediate penetration into the CNS and persistent radioactivity levels in tissues indicative of covalent target modification.
- Published
- 2024
23. Influence of metabolizable protein and methionine supplementation on growth-performance of Holstein steer calves during the initial 112-d feedlot growing phase.
- Author
-
Salinas-Chavira, Jaime, Carvalho, Pedro, Latack, Brooke, Ferraz, Marcos, Montano, Martin, and Zinn, Richard
- Subjects
Holstein ,feedlot ,growth performance ,metabolizable amino acids - Abstract
The objective was to examine the effects of metabolizable protein (MP) and ruminal-protected methionine supplementation on growth performance of Holstein steer calves during the initial feedlot growing phase (112 d). One hundred eighty Holstein steer calves (122 ± 7 kg) were blocked by weight and assigned to 30 pens (6 steers per pen). Five treatments were applied: 1) control, a diet based on steam-flaked corn containing urea and dry distillers grains plus solubles as supplemental N sources with no amino acid addition; 2) control diet plus blood meal supplementation; 3) diet from treatment 2, with 0.064% Smartamine M (70% methionine; Adisseo, Alpharetta, GA) supplementation; 4) diet from treatment 2 with 0.096% Smartamine M supplementation; 5) diet from treatment 2 with 0.128% Smartamine M supplementation. All diets were formulated to exceed the estimated MP requirements. The estimated metabolizable lysine, as well as methionine, was deficient in the control diet. Blood meal was added to the control diet to meet estimated lysine requirements (diet 2), the other diets had increasing concentrations of supplemental methionine. Supplemental MP enhanced (10%, P 0.10). Supplemental MP did not affect (P > 0.10) dry matter intake (DMI) during the first 56-d period; however, it tended to increase (P = 0.08) DMI during the subsequent 56-d period. Overall, supplemental MP or methionine had no appreciable effect (P > 0.10) on DMI. Supplemental MP improved (P 0.10) gain efficiency during the second 56-d period, although it tended to enhance (P = 0.08) estimated dietary NE. Supplemental methionine did not appreciably affect (P > 0.10) gain efficiency or estimated dietary NE. Therefore, adding MP to cover the estimated limiting amino acid supply in diets may enhance the gain efficiency and dietary energetics of growing Holstein calves. However, amino acid addition supplementation beyond the requirements may not produce extra productive performance of steer calves.
- Published
- 2024
24. Large language models can outperform humans in social situational judgments
- Author
-
Mittelstädt, Justin M., Maier, Julia, Goerke, Panja, Zinn, Frank, and Hermes, Michael
- Published
- 2024
- Full Text
- View/download PDF
25. Prognostic significance of pretreatment PET parameters in inoperable, node-positive NSCLC patients with poor prognostic factors undergoing hypofractionated radiotherapy: a single-institution retrospective study
- Author
-
Zinn, Annemarie Barbara, Kenndoff, Saskia, Holzgreve, Adrien, Käsmann, Lukas, Guggenberger, Julian Elias, Hering, Svenja, Mansoorian, Sina, Schmidt-Hegemann, Nina-Sophie, Reinmuth, Niels, Tufman, Amanda, Dinkel, Julien, Manapov, Farkhad, Belka, Claus, and Eze, Chukwuka
- Published
- 2024
- Full Text
- View/download PDF
26. Targeted RT study: results on early toxicity of targeted therapies and radiotherapy
- Author
-
Konnerth, Dinah, Gaasch, Aurelie, Westphalen, C. Benedikt, Heinrich, Kathrin, Niyazi, Maximilian, Eze, Chukwuka, Rogowski, Paul, Marschner, Sebastian, Zinn, Annemarie, Belka, Claus, Corradini, Stefanie, and Schönecker, Stephan
- Published
- 2024
- Full Text
- View/download PDF
27. Author Correction: Characterization of neural mechanotransduction response in human traumatic brain injury organoid model
- Author
-
Beltrán, Susana M., Bobo, Justin, Habib, Ahmed, Kodavali, Chowdari V., Edwards, Lincoln, Mamindla, Priyadarshini, Taylor, Rebecca E., LeDuc, Philip R., and Zinn, Pascal O.
- Published
- 2024
- Full Text
- View/download PDF
28. Fluorescence-guided resection of intradural spinal tumors: a systematic review and meta-analysis
- Author
-
Albalkhi, Ibrahem, Shafqat, Areez, Bin-Alamer, Othman, Abou Al-Shaar, Abdul Rahman, Mallela, Arka N., Fernández-de Thomas, Ricardo J., Zinn, Pascal O., Gerszten, Peter C., Hadjipanayis, Constantinos G., and Abou-Al-Shaar, Hussam
- Published
- 2024
- Full Text
- View/download PDF
29. Challenges in the treatment of soft-tissue plasmacytoma: a retrospective analysis of 120 patients with extramedullary multiple myeloma
- Author
-
Zolnowski, Dominik, Karp, Simone, Warncke, Paul, Zinn, Jessica, Pannach, Marcel, Herbst, Regina, Hänel, Annette, Morgner, Anke, Ibach, Stefan, Fricke, Stephan, and Hänel, Mathias
- Published
- 2024
- Full Text
- View/download PDF
30. Cultivation driven transcriptomic changes in the wild-type and mutant strains of Rhodospirillum rubrum
- Author
-
Katerina Jureckova, Marketa Nykrynova, Eva Slaninova, Hugo Fleuriot-Blitman, Véronique Amstutz, Kristyna Hermankova, Matej Bezdicek, Katerina Mrazova, Kamila Hrubanova, Manfred Zinn, Stanislav Obruca, and Karel Sedlar
- Subjects
Rhodospirillum rubrum ,RNA-Seq ,Transcriptome ,Genome ,Depolymerase knock-out ,Gene ontology ,Biotechnology ,TP248.13-248.65 - Abstract
Purple photosynthetic bacteria (PPB) are versatile microorganisms capable of producing various value-added chemicals, e.g., biopolymers and biofuels. They employ diverse metabolic pathways, allowing them to adapt to various growth conditions and even extreme environments. Thus, they are ideal organisms for the Next Generation Industrial Biotechnology concept of reducing the risk of contamination by using naturally robust extremophiles. Unfortunately, the potential of PPB for use in biotechnology is hampered by missing knowledge on regulations of their metabolism. Although Rhodospirillum rubrum represents a model purple bacterium studied for polyhydroxyalkanoate and hydrogen production, light/chemical energy conversion, and nitrogen fixation, little is known regarding the regulation of its metabolism at the transcriptomic level. Using RNA sequencing, we compared gene expression during the cultivation utilizing fructose and acetate as substrates in case of the wild-type strain R. rubrum DSM 467T and its knock-out mutant strain that is missing two polyhydroxyalkanoate synthases PhaC1 and PhaC2. During this first genome-wide expression study of R. rubrum, we were able to characterize cultivation-driven transcriptomic changes and to annotate non-coding elements as small RNAs.
- Published
- 2024
- Full Text
- View/download PDF
31. Large language models can outperform humans in social situational judgments
- Author
-
Justin M. Mittelstädt, Julia Maier, Panja Goerke, Frank Zinn, and Michael Hermes
- Subjects
Medicine ,Science - Abstract
Abstract Large language models (LLM) have been a catalyst for the public interest in artificial intelligence (AI). These technologies perform some knowledge-based tasks better and faster than human beings. However, whether AIs can correctly assess social situations and devise socially appropriate behavior, is still unclear. We conducted an established Situational Judgment Test (SJT) with five different chatbots and compared their results with responses of human participants (N = 276). Claude, Copilot and you.com’s smart assistant performed significantly better than humans in proposing suitable behaviors in social situations. Moreover, their effectiveness rating of different behavior options aligned well with expert ratings. These results indicate that LLMs are capable of producing adept social judgments. While this constitutes an important requirement for the use as virtual social assistants, challenges and risks are still associated with their wide-spread use in social contexts.
- Published
- 2024
- Full Text
- View/download PDF
32. Prognostic significance of pretreatment PET parameters in inoperable, node-positive NSCLC patients with poor prognostic factors undergoing hypofractionated radiotherapy: a single-institution retrospective study
- Author
-
Annemarie Barbara Zinn, Saskia Kenndoff, Adrien Holzgreve, Lukas Käsmann, Julian Elias Guggenberger, Svenja Hering, Sina Mansoorian, Nina-Sophie Schmidt-Hegemann, Niels Reinmuth, Amanda Tufman, Julien Dinkel, Farkhad Manapov, Claus Belka, and Chukwuka Eze
- Subjects
Baseline PET ,Hypofractionation ,NSCLC ,Poor prognostic factors ,tMTV ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract Background Node-positive non-small cell lung cancers (NSCLCs) present a challenge for treatment decisions, particularly in patients ineligible for concurrent chemoradiotherapy (CRT) due to poor performance status and compromised lung function. We aimed to investigate the prognostic value of pretreatment positron emission tomography (PET) parameters in high-risk patients undergoing hypofractionated radiotherapy. Methods A retrospective analysis was conducted on 42 consecutive patients with inoperable node-positive NSCLC, who underwent hypofractionated radiotherapy between 2014 and 2021 at a single institution. Clinical, treatment-related, and [18F]FDG PET-based parameters were correlated with progression-free survival (PFS) and overall survival (OS). Median dichotomisation was performed to establish risk groups. Statistical analyses included univariable and multivariable Cox regression and Kaplan-Meier survival analyses. Results After a median follow-up of 47.1 months (range: 0.5-101.7), the median PFS and OS were 11.5 months (95% CI: 7.4-22.0), and 24.3 months (95% CI: 14.1-31.8). In univariable Cox regression analysis, significant predictors of PFS included receipt of salvage systemic treatment (p=0.007), SUVmax (p=0.032), and tMTV (p=0.038). Similarly, ECOG-PS (p=0.014), Histology (p=0.046), and tMTV (p=0.028) were significant predictors of OS. Multivariable Cox regression analysis (MVA) identified SUVmax as a significant predictor for PFS [HR: 2.29 (95% CI: 1.02-5.15); p=0.044]. For OS, ECOG-PS remained a significant prognosticator [HR: 3.53 (95% CI: 1.49-8.39); p=0.004], and tMTV approached significance [HR: 2.24 (95% CI: 0.95-5.26); p=0.065]. Furthermore, the high tMTV group exhibited a median PFS of 5.3 months [95% CI: 2.8-10.4], while the low tMTV group had a PFS of 15.2 months [95% CI: 10.1-33.5] (p=0.038, log-rank test). Median OS was 33.5 months [95% CI: 18.3-56.8] for tMTV ≤ 36.6 ml vs. 14.1 months [95% CI: 8.1-27.2] for tMTV > 36.6 ml (p=0.028, log-rank test). Conclusion Pretreatment PET parameters, especially tMTV, hold promise as prognostic indicators in NSCLC patients undergoing hypofractionated radiotherapy. The study highlights the potential of PET metrics as biomarkers for patient stratification.
- Published
- 2024
- Full Text
- View/download PDF
33. The effect of the adiabatic assumption on asteroseismic scaling relations for luminous red giants
- Author
-
Zinn, Joel C., Pinsonneault, Marc H., Bildsten, Lars, and Stello, Dennis
- Subjects
Astrophysics - Solar and Stellar Astrophysics - Abstract
Although stellar radii from asteroseismic scaling relations agree at the percent level with independent estimates for main sequence and most first-ascent red giant branch stars, the scaling relations over-predict radii at the tens of percent level for the most luminous stars ($R \gtrsim 30 R_{\odot}$). These evolved stars have significantly superadiabatic envelopes, and the extent of these regions increase with increasing radius. However, adiabaticity is assumed in the theoretical derivation of the scaling relations as well as in corrections to the large frequency separation. Here, we show that a part of the scaling relation radius inflation may arise from this assumption of adiabaticity. With a new reduction of Kepler asteroseismic data, we find that scaling relation radii and Gaia radii agree to within at least $2\%$ for stars with $R \lesssim 30 R_{\odot}$, when treated under the adiabatic assumption. The accuracy of scaling relation radii for stars with $50 R_{\odot} \lesssim R \lesssim 100 R_{\odot}$, however, is not better than $10\%-15\%$ using adiabatic large frequency separation corrections. We find that up to one third of this disagreement for stars with $R \approx 100 R_{\odot}$ could be caused by the adiabatic assumption, and that this adiabatic error increases with radius to reach $10\%$ at the tip of the red giant branch. We demonstrate that, unlike the solar case, the superadiabatic gradient remains large very deep in luminous stars. A large fraction of the acoustic cavity is also in the optically thin atmosphere. The observed discrepancies may therefore reflect the simplified treatment of convection and atmospheres., Comment: Published in MNRAS
- Published
- 2023
- Full Text
- View/download PDF
34. Constraining stellar and orbital co-evolution through ensemble seismology of solar-like oscillators in binary systems -- A census of oscillating red-giants and main-sequence stars in Gaia DR3 binaries
- Author
-
Beck, P. G., Grossmann, D. H., Steinwender, L., Schimak, L. S., Muntean, N., Vrard, M., Patton, R. A., Merc, J., Mathur, S., Garcia, R. A., Pinsonneault, M. H., Rowan, D. M., Gaulme, P., Prieto, C. Allende, Arellano-Córdova, K. Z., Cao, L., Corsaro, E., Creevey, O., Hambleton, K. M., Hanslmeier, A., Holl, B., Johnson, J., Mathis, S., Godoy-Rivera, D., Símon-Díaz, S., and Zinn, J.
- Subjects
Astrophysics - Solar and Stellar Astrophysics - Abstract
Binary systems constitute a valuable astrophysics tool for testing our understanding of stellar structure and evolution. Systems containing a oscillating component are interesting as asteroseismology offers independent parameters for the oscillating component that aid the analysis. About 150 of such systems are known in the literature. To enlarge the sample of these benchmark objects, we crossmatch the Two-Body-Orbit Catalogue (TBO) of Gaia DR3, with catalogs of confirmed solar-like oscillators on the main-sequence and red-giant phase from NASA Kepler and TESS. We obtain 954 new binary system candidates hosting solar-like oscillators, of which 45 and 909 stars are on the main sequence and red-giant, resp., including 2 new red giants in eclipsing systems. 918 oscillators in potentially long-periodic systems are reported. We increase the sample size of known solar-like oscillators in binary systems by an order of magnitude. We present the seismic properties of the full sample and conclude that the grand majority of the orbital elements in the TBO is physically reasonable. 82% of all TBO binary candidates with multiple times with APOGEE are confirmed from radial-velocity measurement. However, we suggest that due to instrumental noise of the TESS satellite the seismically inferred masses and radii of stars with $\nu_\textrm{max}$$\lesssim$30$\mu$Hz could be significantly overestimated. For 146 giants the seismically inferred evolutionary state has been determined and shows clear differences in their distribution in the orbital parameters, which are accounted the accumulative effect of the equilibrium tide acting in these evolved binary systems. For other 146 systems hosting oscillating stars values for the orbital inclination were found in the TBO. From testing the TBO on the SB9 catalogue, we obtain a completeness factor of 1/3., Comment: accepted for publication in Astronomy&Astrophysics (23 pages + 4 pages of appendix, 21 figures, 33 pages of tables in the Appendix)
- Published
- 2023
35. Asteroseismology with the Roman Galactic Bulge Time-Domain Survey
- Author
-
Huber, Daniel, Pinsonneault, Marc, Beck, Paul, Bedding, Timothy R., Bland-Hawthorn, Joss, Breton, Sylvain N., Bugnet, Lisa, Chaplin, William J., Garcia, Rafael A., Grunblatt, Samuel K., Guzik, Joyce A., Hekker, Saskia, Kawaler, Steven D., Mathis, Stephane, Mathur, Savita, Metcalfe, Travis, Mosser, Benoit, Ness, Melissa K., Piro, Anthony L., Serenelli, Aldo, Sharma, Sanjib, Soderblom, David R., Stassun, Keivan G., Stello, Dennis, Tayar, Jamie, van Belle, Gerard T., and Zinn, Joel C.
- Subjects
Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
Asteroseismology has transformed stellar astrophysics. Red giant asteroseismology is a prime example, with oscillation periods and amplitudes that are readily detectable with time-domain space-based telescopes. These oscillations can be used to infer masses, ages and radii for large numbers of stars, providing unique constraints on stellar populations in our galaxy. The cadence, duration, and spatial resolution of the Roman galactic bulge time-domain survey (GBTDS) are well-suited for asteroseismology and will probe an important population not studied by prior missions. We identify photometric precision as a key requirement for realizing the potential of asteroseismology with Roman. A precision of 1 mmag per 15-min cadence or better for saturated stars will enable detections of the populous red clump star population in the Galactic bulge. If the survey efficiency is better than expected, we argue for repeat observations of the same fields to improve photometric precision, or covering additional fields to expand the stellar population reach if the photometric precision for saturated stars is better than 1 mmag. Asteroseismology is relatively insensitive to the timing of the observations during the mission, and the prime red clump targets can be observed in a single 70 day campaign in any given field. Complementary stellar characterization, particularly astrometry tied to the Gaia system, will also dramatically expand the diagnostic power of asteroseismology. We also highlight synergies to Roman GBTDS exoplanet science using transits and microlensing., Comment: Roman Core Community Survey White Paper, 3 pages, 4 figures
- Published
- 2023
36. STEM Career Choices for K–12 Students and the Influencing Factors—A Comparison of Students in Different Support Programs
- Author
-
Bahr, Tobias, Brändle, Marcus, and Zinn, Bernd
- Published
- 2024
- Full Text
- View/download PDF
37. Effect of high laser scanning speed on microstructure and mechanical properties of additively manufactured 316L
- Author
-
Berghaus, Michael, Florian, Steffen, Solanki, Keyur, Zinn, Carolin, Wang, Hongcai, Butz, Benjamin, Apmann, Hilmar, and von Hehl, Axel
- Published
- 2024
- Full Text
- View/download PDF
38. The role of spine stereotactic radiosurgery for patients with breast cancer metastases
- Author
-
Taori, Suchet, Adida, Samuel, Tang, Anthony, Rajan, Akshath, Sefcik, Roberta K., Burton, Steven A., Flickinger, John C., Zinn, Pascal O., and Gerszten, Peter C.
- Published
- 2024
- Full Text
- View/download PDF
39. Data-driven prediction of the surface layer state in hard-turning for optimization of component quality
- Author
-
Wittich, Felix, Wegener, Thomas, Liehr, Alexander, Zinn, Wolfgang, Niendorf, Thomas, and Kroll, Andreas
- Published
- 2024
- Full Text
- View/download PDF
40. Understanding the biases to sepsis surveillance and quality assurance caused by inaccurate coding in administrative health data
- Author
-
Schwarzkopf, Daniel, Rose, Norman, Fleischmann-Struzek, Carolin, Boden, Beate, Dorow, Heike, Edel, Andreas, Friedrich, Marcus, Gonnert, Falk A., Götz, Jürgen, Gründling, Matthias, Heim, Markus, Holbeck, Kirill, Jaschinski, Ulrich, Koch, Christian, Künzer, Christian, Le Ngoc, Khanh, Lindau, Simone, Mehlmann, Ngoc B., Meschede, Jan, Meybohm, Patrick, Ouart, Dominique, Putensen, Christian, Sander, Michael, Schewe, Jens-Christian, Schlattmann, Peter, Schmidt, Götz, Schneider, Gerhard, Spies, Claudia, Steinsberger, Ferdinand, Zacharowski, Kai, Zinn, Sebastian, and Reinhart, Konrad
- Published
- 2024
- Full Text
- View/download PDF
41. Schubert puzzles and integrability III: separated descents
- Author
-
Knutson, Allen and Zinn-Justin, Paul
- Subjects
Mathematics - Combinatorics - Abstract
In paper I of this series we gave positive formulae for expanding the product $\mathfrak S^\pi \mathfrak S^\rho$ of two Schubert polynomials, in the case that both $\pi,\rho$ had shared descent set of size $\leq 3$. Here we introduce and give positive formulae for two new classes of Schubert product problems: separated descent in which $\pi$'s last descent occurs at (or before) $\rho$'s first, and almost separated descent in which $\pi$'s last two descents occur at (or before) $\rho$'s first two respectively. In both cases our puzzle formulae extend to $K$-theory (multiplying Grothendieck polynomials), and in the separated descent case, to equivariant $K$-theory. The two formulae arise (via quantum integrability) from fusion of minuscule quantized loop algebra representations in types $A$, $D$ respectively.
- Published
- 2023
42. Handheld Haptic Device with Coupled Bidirectional Input
- Author
-
Doshi, Megh Vipul, Hagenow, Michael, Radwin, Robert, Gleicher, Michael, Mutlu, Bilge, and Zinn, Michael
- Subjects
Electrical Engineering and Systems Science - Systems and Control ,Computer Science - Human-Computer Interaction ,Computer Science - Robotics - Abstract
Handheld kinesthetic haptic interfaces can provide greater mobility and richer tactile information as compared to traditional grounded devices. In this paper, we introduce a new handheld haptic interface which takes input using bidirectional coupled finger flexion. We present the device design motivation and design details and experimentally evaluate its performance in terms of transparency and rendering bandwidth using a handheld prototype device. In addition, we assess the device's functional performance through a user study comparing the proposed device to a commonly used grounded input device in a set of targeting and tracking tasks., Comment: 7 pages, 7 figures, World Haptics Conference 2023 Preprint
- Published
- 2023
- Full Text
- View/download PDF
43. The APO-K2 Catalog. I. 7,673 Red Giants with Fundamental Stellar Parameters from APOGEE DR17 Spectroscopy and K2-GAP Asteroseismology
- Author
-
Schonhut-Stasik, Jessica, Zinn, Joel C., Stassun, Keivan G., Pinsonneault, Marc, Johnson, Jennifer A., Warfield, Jack T., Stello, Dennis, Elsworth, Yvonne, Garcia, Rafael A., Marhur, Savita, Mosser, Benoit, Tayar, Jamie, Stringfellow, Guy S., Beaton, Rachael L., Jonsson, Henrik, and Minniti, Dante
- Subjects
Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
We present a catalog of fundamental stellar properties for 7,673 evolved stars, including stellar radii and masses, determined from the combination of spectroscopic observations from the Apache Point Observatory Galactic Evolution Experiment (APOGEE), part of the Sloan Digital Sky Survey IV (SDSS), and asteroseismology from K2. The resulting APO-K2 catalog provides spectroscopically derived temperatures and metallicities, asteroseismic global parameters, evolutionary states, and asteroseismically-derived masses and radii. Additionally, we include kinematic information from \textit{Gaia}. We investigate the multi-dimensional space of abundance, stellar mass, and velocity with an eye toward applications in Galactic archaeology. The APO-K2 sample has a large population of low metallicity stars ($\sim$288 at [M/H] $\leq$ $-$1), and their asteroseismic masses are larger than astrophysical estimates. We argue that this may reflect offsets in the adopted fundamental temperature scale for metal-poor stars rather than metallicity-dependent issues with interpreting asteroseismic data. We characterize the kinematic properties of the population as a function of $\alpha$-enhancement and position in the disk and identify those stars in the sample that are candidate components of the \textit{Gaia-Enceladus} merger. Importantly, we characterize the selection function for the APO-K2 sample as a function of metallicity, radius, mass, $\nu_{\mathrm{max}}$, color, and magnitude referencing Galactic simulations and target selection criteria to enable robust statistical inferences with the catalog., Comment: 28 Pages, 14 Figures, 1 Table. Full table and selection function data available at https://github.com/Jesstella/APO-K2. Submitted April 18th 2023 with AJ, awaiting review
- Published
- 2023
44. Targeted RT study: results on early toxicity of targeted therapies and radiotherapy
- Author
-
Dinah Konnerth, Aurelie Gaasch, C. Benedikt Westphalen, Kathrin Heinrich, Maximilian Niyazi, Chukwuka Eze, Paul Rogowski, Sebastian Marschner, Annemarie Zinn, Claus Belka, Stefanie Corradini, and Stephan Schönecker
- Subjects
Medical physics. Medical radiology. Nuclear medicine ,R895-920 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Purpose/objective Currently, there are few prospective data on the tolerability of combining targeted therapies (TT) with radiation therapy (RT). The objective of this prospective study was to assess the feasibility and toxicity of pairing RT with concurrent TT in cancer patients. The aim was to enhance the existing evidence base for the simultaneous administration of targeted substances together with radiotherapy. Methods Prospective study enrollment was conducted at a single institution between March 1, 2020, and December 31, 2021, for all patients diagnosed with histologically confirmed cancer who underwent external beam radiotherapy in combination with targeted therapy. The study, known as the “targeted RT study,” was registered in the German Clinical Trials Register under DRKS00026193. Systematic documentation of the toxicity profiles of different targeted therapies was performed, and the assessment of acute toxicity followed the guidelines of the National Cancer Institute Common Terminology Criteria for Adverse Events Version v5.0. Results A total of 334 patients underwent 683 radiation therapy series. During the course of RT, 51 different TT substances were concurrently administered. External beam radiotherapy was employed for various anatomical sites. The combination of RT and concurrent TT administration was generally well tolerated, with no instances of severe acute toxicity observed. The most commonly reported toxicity was fatigue, ranging from mild to moderate Common Terminology Criteria for Adverse Events (CTCAE) °I-°III. Other frequently observed toxicities included dermatitis, dyspnea, dysphagia, and dry cough. No toxicity greater than moderate severity was recorded at any point. In only 32 patients (4.7% of evaluated RT series), the concurrent substance administration was discontinued due to side effects. However, these side effects did not exceed mild severity according to CTCAE, suggesting that discontinuation was a precautionary measure. Only one patient receiving Imatinib treatment experienced a severe CTCAE °III side effect, leading to discontinuation of the concurrent substance due to the sudden occurrence of melaena during RT. Conclusion In conclusion, the current study did not demonstrate a significant increase or additional toxicity when combining radiotherapy and concurrent targeted therapy. However, additional research is required to explore the specific toxicity profiles of the various substances that can be utilized in this context. Trial registration number DRKS00026193. Date of registration 12/27/2022 (retrospectively registered).
- Published
- 2024
- Full Text
- View/download PDF
45. Effect of Combining the Ionophore Monensin with Natural Antimicrobials Supplemented in the Last Phase of Finishing of Lambs: Growth Performance, Dietary Energetics, and Carcass Characteristics.
- Author
-
Estrada-Angulo, Alfredo, Escobedo-Gallegos, Lucía, Arteaga-Wences, Yesica, Ramos-Méndez, Jorge, Quezada-Rubio, Jesús, Vizcarra-Chávez, Claudia, Valdés-García, Yissel, Barreras, Alberto, Plascencia, Alejandro, and Zinn, Richard
- Subjects
carcass ,energetics ,growth-performance ,lambs ,monensin ,natural additives - Abstract
With the aim of evaluating the effect of combining an antibiotic ionophore with plant extracts and probiotics on the productive efficiency (performance and carcass) during the last phase of lamb fattening, 24 Pelibuey × Katahdin male lambs (38.47 ± 3.92 kg, initial weight) were fed with a high-energy diet during for 56 days, and assigned, under a complete randomized block design experiment to one of the following supplement treatments: (1) 28 mg of monensin/kg diet DM supplemented alone (MON), (2) combination of MON plus 2 g/kg diet of a product contained Bacillus subtilis 2.2 × 108 CFU kg diet DM (MON + BS), (3) combination of MON + BS plus 300 mg essential oils/kg diet DM (MON + BS + EO), and (4) BS alone. At the end of the feeding trial (56-d), lambs were slaughtered and carcass variables were measured. Compared to the rest of the treatments, combining MON with BS improved dietary NE by 3.4% and the efficiency of utilization of dietary energy consumed. Inclusion of EO in the MON + BS combination resulted in a similar average daily weight gain (ADG) and feed efficiency (GF) when compared with MON + BS, but showed a lower dietary net energy (NE), hot carcass weight, and dressing percentage. Lambs receiving BS alone showed greater average ADG and dry matter intake (DMI) than lambs receiving MON + BS + EO, but similar feed GF and dietary NE. There were no treatment effects on tissue composition, whole cut, or visceral organ mass. It was concluded that combining probiotics with the ionophore monensin can improve the efficiency of dietary energy utilization in the last phase of finishing. Probiotics supplemented alone result in greater ADG without a difference in dietary energy efficiency when compared with MON alone. Inclusion of EO in the MON + BS combination did not show advantages; on the contrary, it reduced carcass weight and dressing percentage. It is necessary to further research the potential complementary effects of combining diverse sources of natural additives with synthetic antibiotics.
- Published
- 2023
46. Essential Oils Combined with Vitamin D3 or with Probiotic as an Alternative to the Ionophore Monensin Supplemented in High-Energy Diets for Lambs Long-Term Finished under Subtropical Climate.
- Author
-
Escobedo-Gallegos, Lucía, Estrada-Angulo, Alfredo, Castro-Pérez, Beatriz, Urías-Estrada, Jesús, Calderón-Garay, Elizabeth, Ramírez-Santiago, Laura, Valdés-García, Yissel, Barreras, Alberto, Plascencia, Alejandro, and Zinn, Richard
- Subjects
carcass ,energetics ,growth-performance ,lambs ,monensin ,natural additives - Abstract
Supplementation with natural additives such as essential oils (EO) or probiotics has resulted in comparable growth performance to that of supplemental monensin in fattening lambs in hot environments. Supra-supplementation levels of vitamin D3 improved the carcass weight and dressing percentage of steers fattened under tropical conditions. We hypothesized that certain combinations of these natural additives could be complementary. For this reason, a feeding trial was carried out using 48 Pelibuey × Katahdin non-castrated male lambs (107 ± 14 d age; 17.9 ± 2.51 kg LW). Lambs were fed an 88:12 concentrate to forage ratio basal diet supplemented (dry matter basis, DMI) with: (1) no additive (CON); (2) 28 mg monensin/kg diet (MON); (3) 150 mg of essential oils containing a combination of thymol, eugenol, vanillin, guaiac, and limonene plus 0.12 mg vitamin D3 (EO + D3)/kg diet; and (4) 300 mg of essential oils containing a combination of carvacrol and cynamaldehyde plus 2 g probiotic (2.2 × 108 CFU of bacillus subtilis/kg diet, EO + BS). Lambs were grouped by initial weight and assigned within six weight groupings to 24 pens (2 lambs/pen, 6 replicas per treatment) in a randomized complete block design. The experiment lasted 121 days. Daily maximal THI exceeded the 80 danger or emergency range for 119 days of the 121 days of the trial. Lambs supplemented with MON had similar DMI, growth performance, and dietary energetics to those of CON lambs. Lambs supplemented with EO + BS had a greater (9.2%, p ≤ 0.05) average daily gain (ADG) than the CON and MON groups due to enhanced (10.2%, p ≤ 0.05) dry matter intake. Thus, gain efficiency (GF) and estimated dietary energy were similar for CON, MON, and EO + BS. Lambs receiving EO + D3 had similar (0.254 vs. 0.262 kg/d) ADG but a lower DMI (8%, p < 0.05) compared with EO + BS lambs. Consequently, GF and estimated dietary net energy were greater (4.9 and 3.7%, respectively; p ≤ 0.05) for EO + D3 lambs. Even when ambient heat load was elevated, the efficiency of utilization of dietary energy (observed-to-expected dietary net energy) was close to 1.00 (0.992) expected for EO + D3 lambs. In contrast, efficiency of energy utilization was depressed by -4.4% for lambs on the other treatments. Compared with the other treatments, lambs receiving EO + D3 had greater longissimus muscle area (5.6%, p < 0.05) and lower kidney pelvic fat (21.8%, p ≤ 0.05). There were no treatment effects on shoulder tissue composition or whole cuts (expressed as % of cold carcass weight). Compared to CON, lambs that were fed with natural additives showed 3.5% lower (p ≤ 0.05) intestine mass. All supplemental additives decreased visceral fat mass, which was minimal with EO + D3 treatment. Combinations of essential oils with vitamins or probiotics were superior to antibiotic monensin in finishing diets for feedlot lambs. Combining EO with probiotics promoted DM intake and gain but not gain efficiency, while combining EO with vitamin D3 supra-supplementation increased dietary energy efficiency and improved some carcass characteristics in lambs fattening under high ambient heat loads.
- Published
- 2023
47. Correction to: A case series and review of stereotactic body radiation therapy for contiguous multilevel spine metastases
- Author
-
Adida, Samuel, Taori, Suchet, Bhatia, Shovan, Kann, Michael R., Burton, Steven A., Flickinger, John C., Olson, Adam C., Sefcik, Roberta K., Zinn, Pascal O., and Gerszten, Peter C.
- Published
- 2024
- Full Text
- View/download PDF
48. Coordinated Multi-Robot Shared Autonomy Based on Scheduling and Demonstrations
- Author
-
Hagenow, Michael, Senft, Emmanuel, Orr, Nitzan, Radwin, Robert, Gleicher, Michael, Mutlu, Bilge, Losey, Dylan P., and Zinn, Michael
- Subjects
Computer Science - Robotics - Abstract
Shared autonomy methods, where a human operator and a robot arm work together, have enabled robots to complete a range of complex and highly variable tasks. Existing work primarily focuses on one human sharing autonomy with a single robot. By contrast, in this paper we present an approach for multi-robot shared autonomy that enables one operator to provide real-time corrections across two coordinated robots completing the same task in parallel. Sharing autonomy with multiple robots presents fundamental challenges. The human can only correct one robot at a time, and without coordination, the human may be left idle for long periods of time. Accordingly, we develop an approach that aligns the robot's learned motions to best utilize the human's expertise. Our key idea is to leverage Learning from Demonstration (LfD) and time warping to schedule the motions of the robots based on when they may require assistance. Our method uses variability in operator demonstrations to identify the types of corrections an operator might apply during shared autonomy, leverages flexibility in how quickly the task was performed in demonstrations to aid in scheduling, and iteratively estimates the likelihood of when corrections may be needed to ensure that only one robot is completing an action requiring assistance. Through a preliminary study, we show that our method can decrease the scheduled time spent sanding by iteratively estimating the times when each robot could need assistance and generating an optimized schedule that allows the operator to provide corrections to each robot during these times., Comment: IEEE Robotics and Automation Letters (RA-L)
- Published
- 2023
49. Transient Hemodynamics Prediction Using an Efficient Octree-Based Deep Learning Model
- Author
-
Maul, Noah, Zinn, Katharina, Wagner, Fabian, Thies, Mareike, Rohleder, Maximilian, Pfaff, Laura, Kowarschik, Markus, Birkhold, Annette, and Maier, Andreas
- Subjects
Computer Science - Machine Learning ,68T07 (Primary), 92C50, 92C35 (Secondary) ,I.2.1 ,J.3 - Abstract
Patient-specific hemodynamics assessment could support diagnosis and treatment of neurovascular diseases. Currently, conventional medical imaging modalities are not able to accurately acquire high-resolution hemodynamic information that would be required to assess complex neurovascular pathologies. Therefore, computational fluid dynamics (CFD) simulations can be applied to tomographic reconstructions to obtain clinically relevant information. However, three-dimensional (3D) CFD simulations require enormous computational resources and simulation-related expert knowledge that are usually not available in clinical environments. Recently, deep-learning-based methods have been proposed as CFD surrogates to improve computational efficiency. Nevertheless, the prediction of high-resolution transient CFD simulations for complex vascular geometries poses a challenge to conventional deep learning models. In this work, we present an architecture that is tailored to predict high-resolution (spatial and temporal) velocity fields for complex synthetic vascular geometries. For this, an octree-based spatial discretization is combined with an implicit neural function representation to efficiently handle the prediction of the 3D velocity field for each time step. The presented method is evaluated for the task of cerebral hemodynamics prediction before and during the injection of contrast agent in the internal carotid artery (ICA). Compared to CFD simulations, the velocity field can be estimated with a mean absolute error of 0.024 m/s, whereas the run time reduces from several hours on a high-performance cluster to a few seconds on a consumer graphical processing unit., Comment: 13 pages, 5 figures
- Published
- 2023
50. Blended think-pair-share with SpeakUp as inclusive and engaging pedagogical activity
- Author
-
Zinn, Isabelle, primary and Holzer, Adrian, additional
- Published
- 2024
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.