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1. The PI3K-AKT-mTOR axis persists as a therapeutic dependency in KRASG12D-driven non-small cell lung cancer

Author

W. J. McDaid, L. Wilson, H. Adderley, A. Martinez-Lopez, M. J. Baker, J. Searle, L. Ginn, T. Budden, M. Aldea, A. Marinello, J. V. Aredo, A. Viros, B. Besse, H. A. Wakelee, F. Blackhall, S. Castillo-Lluva, C. R. Lindsay, and A. Malliri

Subjects
KRAS, NSCLC, PI3K-AKT-mTOR pathway, KRASG12D inhibition, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Introduction KRASG12C and KRASG12D inhibitors represent a major translational breakthrough for non-small cell lung cancer (NSCLC) and cancer in general by directly targeting its most mutated oncoprotein. However, resistance to these small molecules has highlighted the need for rational combination partners necessitating a critical understanding of signaling downstream of KRAS mutant isoforms. Methods We contrasted tumor development between Kras G12C and Kras G12D genetically engineered mouse models (GEMMs). To corroborate findings and determine mutant subtype-specific dependencies, isogenic models of Kras G12C and Kras G12D initiation and adaptation were profiled by RNA sequencing. We also employed cell line models of established KRAS mutant NSCLC and determined therapeutic vulnerabilities through pharmacological inhibition. We analysed differences in survival outcomes for patients affected by advanced KRAS G12C or KRAS G12D -mutant NSCLC. Results KRASG12D exhibited higher potency in vivo, manifesting as more rapid lung tumor formation and reduced survival of KRASG12D GEMMs compared to KRASG12C. This increased potency, recapitulated in an isogenic initiation model, was associated with enhanced PI3K-AKT-mTOR signaling. However, KRASG12C oncogenicity and downstream pathway activation were comparable with KRASG12D at later stages of tumorigenesis in vitro and in vivo, consistent with similar clinical outcomes in patients. Despite this, established KRASG12D NSCLC models depended more on the PI3K-AKT-mTOR pathway, while KRASG12C models on the MAPK pathway. Specifically, KRASG12D inhibition was enhanced by AKT inhibition in vitro and in vivo. Conclusions Our data highlight a unique combination treatment vulnerability and suggest that patient selection strategies for combination approaches using direct KRAS inhibitors should be i) contextualised to individual RAS mutants, and ii) tailored to their downstream signaling.

Published
2024
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2. SudokuSens: Enhancing Deep Learning Robustness for IoT Sensing Applications using a Generative Approach

Author

Wang, Tianshi, Li, Jinyang, Wang, Ruijie, Kara, Denizhan, Liu, Shengzhong, Wertheimer, Davis, Viros-i-Martin, Antoni, Ganti, Raghu, Srivatsa, Mudhakar, and Abdelzaher, Tarek

Subjects
Computer Science - Machine Learning
Abstract

This paper introduces SudokuSens, a generative framework for automated generation of training data in machine-learning-based Internet-of-Things (IoT) applications, such that the generated synthetic data mimic experimental configurations not encountered during actual sensor data collection. The framework improves the robustness of resulting deep learning models, and is intended for IoT applications where data collection is expensive. The work is motivated by the fact that IoT time-series data entangle the signatures of observed objects with the confounding intrinsic properties of the surrounding environment and the dynamic environmental disturbances experienced. To incorporate sufficient diversity into the IoT training data, one therefore needs to consider a combinatorial explosion of training cases that are multiplicative in the number of objects considered and the possible environmental conditions in which such objects may be encountered. Our framework substantially reduces these multiplicative training needs. To decouple object signatures from environmental conditions, we employ a Conditional Variational Autoencoder (CVAE) that allows us to reduce data collection needs from multiplicative to (nearly) linear, while synthetically generating (data for) the missing conditions. To obtain robustness with respect to dynamic disturbances, a session-aware temporal contrastive learning approach is taken. Integrating the aforementioned two approaches, SudokuSens significantly improves the robustness of deep learning for IoT applications. We explore the degree to which SudokuSens benefits downstream inference tasks in different data sets and discuss conditions under which the approach is particularly effective., Comment: Published in ACM Conference on Embedded Networked Sensor Systems (SenSys 23), November, 2023, Istanbul, Turkiye. This is the author's version of the work. It is posted here for your personal use. Not for redistribution. Publication rights licensed to the Association for Computing Machinery

Published
2024
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3. Attack-Resilient Image Watermarking Using Stable Diffusion

Author

Zhang, Lijun, Liu, Xiao, Martin, Antoni Viros, Bearfield, Cindy Xiong, Brun, Yuriy, and Guan, Hui

Subjects
Computer Science - Computer Vision and Pattern Recognition, Computer Science - Artificial Intelligence
Abstract

Watermarking images is critical for tracking image provenance and proving ownership. With the advent of generative models, such as stable diffusion, that can create fake but realistic images, watermarking has become particularly important to make human-created images reliably identifiable. Unfortunately, the very same stable diffusion technology can remove watermarks injected using existing methods. To address this problem, we present ZoDiac, which uses a pre-trained stable diffusion model to inject a watermark into the trainable latent space, resulting in watermarks that can be reliably detected in the latent vector even when attacked. We evaluate ZoDiac on three benchmarks, MS-COCO, DiffusionDB, and WikiArt, and find that ZoDiac is robust against state-of-the-art watermark attacks, with a watermark detection rate above 98% and a false positive rate below 6.4%, outperforming state-of-the-art watermarking methods. We hypothesize that the reciprocating denoising process in diffusion models may inherently enhance the robustness of the watermark when faced with strong attacks and validate the hypothesis. Our research demonstrates that stable diffusion is a promising approach to robust watermarking, able to withstand even stable-diffusion--based attack methods. ZoDiac is open-sourced and available at https://github.com/zhanglijun95/ZoDiac., Comment: 28 pages, 11 figures; NeurIPS24

Published
2024

4. High-rate, high-resolution single photon X-ray imaging: Medipix4, a large 4-side buttable pixel readout chip with high granularity and spectroscopic capabilities

Author

Sriskaran, Viros, Alozy, Jerome, Ballabriga, Rafael, Campbell, Michael, Christodoulou, Pinelopi, Heijne, Erik, Koukab, Adil, Kugathasan, Thanushan, Llopart, Xavier, Piller, Markus, Pulli, Adithya, Sallese, Jean-Michel, and Tlustos, Lukas

Subjects
Physics - Instrumentation and Detectors
Abstract

The Medipix4 chip is the latest member in the Medipix/Timepix family of hybrid pixel detector chips aimed at high-rate spectroscopic X-ray imaging using high-Z materials. It can be tiled on all 4 sides making it ideal for constructing large-area detectors with minimal dead area. The chip is designed to read out a sensor of 320 x 320 pixels with dimensions of 75 {\mu}m x 75 {\mu}m or 160 x 160 pixels with dimensions of 150 {\mu}m x 150 {\mu}m. The readout architecture features energy binning of the single photons, which includes charge sharing correction for hits with energy spread over adjacent pixels. This paper presents the specifications, architecture, and circuit implementation of the chip, along with the first electrical measurements.

Published
2023

9. Population-based evaluation of the impact of socioeconomic status on clinical outcomes in patients with heart failure in integrated care settings

Author

Capdevila Aguilera, Cristina, Vela Vallespín, Emili, Clèries Escayola, Montse, Yun Viladomat, Sergi, Fernández Solana, Coral, Alcober Morte, Laia, Monterde Prat, David, Hidalgo Quirós, Encarna, Calero Molina, Esther, José Bazán, Núria, Moliner Borja, Pedro, Piera Jiménez, Jordi, Ruiz Muñoz, Marta, Corbella Virós, Xavier, Jiménez-Marrero, Santiago, Garay Melero, Alberto, Ramos Polo, Raúl, Alcoberro Torres, Lidia, Pons Riverola, Alexandra, Enjuanes Grau, Cristina, and Comín-Colet, Josep

Published
2023
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10. Evaluación poblacional del impacto del nivel socioeconómico en los resultados clínicos en pacientes con insuficiencia cardiaca en entornos de atención integrada

Author

Capdevila Aguilera, Cristina, Vela Vallespín, Emili, Clèries Escayola, Montse, Yun Viladomat, Sergi, Fernández Solana, Coral, Alcober Morte, Laia, Monterde Prat, David, Hidalgo Quirós, Encarna, Calero Molina, Esther, José Bazán, Núria, Moliner Borja, Pedro, Piera Jiménez, Jordi, Ruiz Muñoz, Marta, Corbella Virós, Xavier, Jiménez-Marrero, Santiago, Garay Melero, Alberto, Ramos Polo, Raúl, Alcoberro Torres, Lidia, Pons Riverola, Alexandra, Enjuanes Grau, Cristina, and Comín-Colet, Josep

Published
2023
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12. Molecular characterization of fast-growing melanomas

Author

Gaudy-Marqueste, Caroline, Macagno, Nicolas, Loundou, Anderson, Pellegrino, Eric, Ouafik, L'houcine, Budden, Timothy, Mundra, Piyushkumar, Gremel, Gabriela, Akhras, Victoria, Lin, Lijing, Cook, Martin, Kumar, Rajiv, Grob, Jean-Jacques, Nagore, Eduardo, Marais, Richard, and Virós, Amaya

Published
2022
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17. Robust Image Watermarking using Stable Diffusion

Author

Zhang, Lijun, Liu, Xiao, Martin, Antoni Viros, Bearfield, Cindy Xiong, Brun, Yuriy, Guan, Hui, Zhang, Lijun, Liu, Xiao, Martin, Antoni Viros, Bearfield, Cindy Xiong, Brun, Yuriy, and Guan, Hui

Abstract

Watermarking images is critical for tracking image provenance and claiming ownership. With the advent of generative models, such as stable diffusion, able to create fake but realistic images, watermarking has become particularly important, e.g., to make generated images reliably identifiable. Unfortunately, the very same stable diffusion technology can remove watermarks injected using existing methods. To address this problem, we present a ZoDiac, which uses a pre-trained stable diffusion model to inject a watermark into the trainable latent space, resulting in watermarks that can be reliably detected in the latent vector, even when attacked. We evaluate ZoDiac on three benchmarks, MS-COCO, DiffusionDB, and WikiArt, and find that ZoDiac is robust against state-of-the-art watermark attacks, with a watermark detection rate over 98% and a false positive rate below 6.4%, outperforming state-of-the-art watermarking methods. Our research demonstrates that stable diffusion is a promising approach to robust watermarking, able to withstand even stable-diffusion-based attacks., Comment: 15 pages, 14 figures

Published
2024

19. A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity.

Author

Conde-Perez, Alejandro, Gros, Gwendoline, Longvert, Christine, Pedersen, Malin, Petit, Valérie, Aktary, Zackie, Viros, Amaya, Gesbert, Franck, Delmas, Véronique, Rambow, Florian, Bastian, Boris C, Campbell, Andrew D, Colombo, Sophie, Puig, Isabel, Bellacosa, Alfonso, Sansom, Owen, Marais, Richard, Van Kempen, Leon CLT, and Larue, Lionel

Subjects
Cell Line, Tumor, Melanocytes, Animals, Mice, Transgenic, Humans, Mice, Melanoma, Skin Neoplasms, GTP Phosphohydrolases, Glycogen Synthase Kinase 3, Cadherins, Membrane Proteins, MicroRNAs, Microscopy, Fluorescence, Blotting, Western, Prognosis, Immunohistochemistry, Proto-Oncogene Proteins c-akt, PTEN Phosphohydrolase, beta Catenin, Caveolin 1, Transcriptional Activation, Feedback, Physiological, Phosphatidylinositol 3-Kinases, Glycogen Synthase Kinase 3 beta, Cell Line, Tumor, Transgenic, Microscopy, Fluorescence, Blotting, Western, Feedback, Physiological
Abstract

Loss of the tumour suppressor PTEN is frequent in human melanoma, results in MAPK activation, suppresses senescence and mediates metastatic behaviour. How PTEN loss mediates these effects is unknown. Here we show that loss of PTEN in epithelial and melanocytic cell lines induces the nuclear localization and transcriptional activation of β-catenin independent of the PI3K-AKT-GSK3β axis. The absence of PTEN leads to caveolin-1 (CAV1)-dependent β-catenin transcriptional modulation in vitro, cooperates with NRAS(Q61K) to initiate melanomagenesis in vivo and induces efficient metastasis formation associated with E-cadherin internalization. The CAV1-β-catenin axis is mediated by a feedback loop in which β-catenin represses transcription of miR-199a-5p and miR-203, which suppress the levels of CAV1 mRNA in melanoma cells. These data reveal a mechanism by which loss of PTEN increases CAV1-mediated dissociation of β-catenin from membranous E-cadherin, which may promote senescence bypass and metastasis.

Published
2015

24. 3D-CHESS: Decentralized, Distributed, Dynamic, and Context-aware Heterogeneous Sensor Systems

Author

David, Cedric H, Ravindra, Vinay, Nag, Sreeja, Mehta, Ankur, Sun, Yizhou, Viros Martin, Antoni, Jaramillo, Alan Aguilar, Gorr, Ben, Gao, Huilin, Allen, George, and Selva, Daniel

Abstract

This paper describes the objectives and current status of the 3D-CHESS project which aims to demonstrate a new Earth observing strategy based on a context-aware Earth observing sensor web. This sensor web consists of a set of nodes with a knowledge base, heterogeneous sensors, edge computing, and autonomous decision-making capabilities. Context awareness is defined as the ability for the nodes to gather, exchange, and leverage contextual information (e.g., state of the Earth system, state and capabilities of itself and of other nodes in the network, and how those states relate to the dy- namic mission objectives) to improve decision making and planning. The current goal of the project is to demonstrate proof of concept by comparing the performance of a 3D- CHESS sensor web with that of status quo architectures in the context of a multi-sensor inland hydrologic and ecologic monitoring system.

Published
2022

26. Mechanisms of Drug Resistance in Melanoma

Author

Winder, Matthew, Virós, Amaya, Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Series Editor, Frohman, Michael A., Series Editor, Geppetti, Pierangelo, Series Editor, Hofmann, Franz B., Series Editor, Michel, Martin C., Series Editor, Page, Clive P., Series Editor, Rosenthal, Walter, Series Editor, Wang, KeWei, Series Editor, Mandalà, Mario, editor, and Romano, Emanuela, editor

Published
2018
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27. Transoral Oropharyngeal Resection Classification: Proposal of the SCORL Working Group

Author

Virós Porcuna, David, Avilés Jurado, Francisco, Pollán Guisasola, Carlos, Ramírez Ruiz, Rosa Delia, García Lorenzo, Jacinto, Tobed Secall, Marc, Vilaseca González, Isabel, Costa González, José Miguel, Soteras Olle, Josep, Casamitjana Claramunt, Francesc, Sumarroca Trouboul, Anna, Hijano Esqué, Rafael, Viscasillas Pallàs, Guillem, Mañós Pujol, Manel, and Quer Agustí, Miquel

Published
2017
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28. Clasificación de las resecciones transorales en la orofaringe: propuesta del grupo de trabajo de la Sociedad Catalana de Otorrinolaringología

Author

Virós Porcuna, David, Avilés Jurado, Francisco, Pollán Guisasola, Carlos, Ramírez Ruiz, Rosa Delia, García Lorenzo, Jacinto, Tobed Secall, Marc, Vilaseca González, Isabel, Costa González, José Miguel, Soteras Olle, Josep, Casamitjana Claramunt, Francesc, Sumarroca Trouboul, Anna, Hijano Esqué, Rafael, Viscasillas Pallàs, Guillem, Mañós Pujol, Manel, and Quer Agustí, Miquel

Published
2017
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29. Ultraviolet radiation-induced DNA damage is prognostic for outcome in melanoma

Author

Trucco, Lucas D., Mundra, Piyushkumar A., Hogan, Kate, Garcia-Martinez, Pablo, Viros, Amaya, Mandal, Amit K., and Macagno, Nicolas

Subjects
Care and treatment, Usage, Development and progression, Research, Genetic aspects, Prognosis, Ultraviolet radiation -- Usage, Gene mutation -- Research, Melanoma -- Genetic aspects -- Care and treatment -- Development and progression -- Prognosis, Cancer research, Radiation (Physics), Skin cancer, Cancer, Medical research, Genomics, Universities and colleges, DNA, Genes, Genomes, Skin, DNA damage
Abstract

Author(s): Lucas D. Trucco [sup.1] , Piyushkumar A. Mundra [sup.1] , Kate Hogan [sup.1] , Pablo Garcia-Martinez [sup.1] , Amaya Viros [sup.1] , Amit K. Mandal [sup.1] , Nicolas Macagno [...], The melanoma genome is dominated by ultraviolet radiation (UVR)-induced mutations. Their relevance in disease progression is unknown. Here we classify melanomas by mutation signatures and identify ten recurrently mutated UVR signature genes that predict patient survival. We validate these findings in primary human melanomas; in mice we show that this signature is imprinted by short-wavelength UVR and that four exposures to UVR are sufficient to accelerate melanomagenesis. Mutational signatures in melanoma are associated with prognostic features in patients and suggest distinct disease etiologies associated with the influence of different wavelengths of ultraviolet radiation.

Published
2019
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31. The PI3K-AKT-mTOR axis persists as a therapeutic dependency in KRASG12D-driven non-small cell lung cancer

Author

McDaid, W. J., primary, Wilson, L., additional, Adderley, H., additional, Baker, M. J., additional, Searle, J., additional, Ginn, L., additional, Budden, T., additional, Aldea, M., additional, Marinello, A., additional, Aredo, J., additional, Viros, A., additional, Besse, B., additional, Wakelee, H. A., additional, Blackhall, F., additional, Lindsay, C. R., additional, and Malliri, A., additional

Published
2023
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35. Supplementary Table S4 from Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma

Author

Girotti, Maria R., primary, Pedersen, Malin, primary, Sanchez-Laorden, Berta, primary, Viros, Amaya, primary, Turajlic, Samra, primary, Niculescu-Duvaz, Dan, primary, Zambon, Alfonso, primary, Sinclair, John, primary, Hayes, Andrew, primary, Gore, Martin, primary, Lorigan, Paul, primary, Springer, Caroline, primary, Larkin, James, primary, Jorgensen, Claus, primary, and Marais, Richard, primary

Published
2023
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36. Data from Application of Sequencing, Liquid Biopsies, and Patient-Derived Xenografts for Personalized Medicine in Melanoma

Author

Girotti, Maria Romina, primary, Gremel, Gabriela, primary, Lee, Rebecca, primary, Galvani, Elena, primary, Rothwell, Dominic, primary, Viros, Amaya, primary, Mandal, Amit Kumar, primary, Lim, Kok Haw Jonathan, primary, Saturno, Grazia, primary, Furney, Simon J., primary, Baenke, Franziska, primary, Pedersen, Malin, primary, Rogan, Jane, primary, Swan, Jacqueline, primary, Smith, Matthew, primary, Fusi, Alberto, primary, Oudit, Deemesh, primary, Dhomen, Nathalie, primary, Brady, Ged, primary, Lorigan, Paul, primary, Dive, Caroline, primary, and Marais, Richard, primary

Published
2023
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37. Data from Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma

Author

Girotti, Maria R., primary, Pedersen, Malin, primary, Sanchez-Laorden, Berta, primary, Viros, Amaya, primary, Turajlic, Samra, primary, Niculescu-Duvaz, Dan, primary, Zambon, Alfonso, primary, Sinclair, John, primary, Hayes, Andrew, primary, Gore, Martin, primary, Lorigan, Paul, primary, Springer, Caroline, primary, Larkin, James, primary, Jorgensen, Claus, primary, and Marais, Richard, primary

Published
2023
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39. Supplementary Figure 4 from Primary Melanoma of the CNS in Children Is Driven by Congenital Expression of Oncogenic NRAS in Melanocytes

Author

Pedersen, Malin, primary, Küsters-Vandevelde, Heidi V.N., primary, Viros, Amaya, primary, Groenen, Patricia J.T.A., primary, Sanchez-Laorden, Berta, primary, Gilhuis, Jacobus H., primary, van Engen-van Grunsven, Ilse A., primary, Renier, Willy, primary, Schieving, Jolanda, primary, Niculescu-Duvaz, Ion, primary, Springer, Caroline J., primary, Küsters, Benno, primary, Wesseling, Pieter, primary, Blokx, Willeke A.M., primary, and Marais, Richard, primary

Published
2023
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40. Supplementary Figure S1 - S3 from Application of Sequencing, Liquid Biopsies, and Patient-Derived Xenografts for Personalized Medicine in Melanoma

Author

Girotti, Maria Romina, primary, Gremel, Gabriela, primary, Lee, Rebecca, primary, Galvani, Elena, primary, Rothwell, Dominic, primary, Viros, Amaya, primary, Mandal, Amit Kumar, primary, Lim, Kok Haw Jonathan, primary, Saturno, Grazia, primary, Furney, Simon J., primary, Baenke, Franziska, primary, Pedersen, Malin, primary, Rogan, Jane, primary, Swan, Jacqueline, primary, Smith, Matthew, primary, Fusi, Alberto, primary, Oudit, Deemesh, primary, Dhomen, Nathalie, primary, Brady, Ged, primary, Lorigan, Paul, primary, Dive, Caroline, primary, and Marais, Richard, primary

Published
2023
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42. Supplementary Table S1 from Application of Sequencing, Liquid Biopsies, and Patient-Derived Xenografts for Personalized Medicine in Melanoma

Author

Girotti, Maria Romina, primary, Gremel, Gabriela, primary, Lee, Rebecca, primary, Galvani, Elena, primary, Rothwell, Dominic, primary, Viros, Amaya, primary, Mandal, Amit Kumar, primary, Lim, Kok Haw Jonathan, primary, Saturno, Grazia, primary, Furney, Simon J., primary, Baenke, Franziska, primary, Pedersen, Malin, primary, Rogan, Jane, primary, Swan, Jacqueline, primary, Smith, Matthew, primary, Fusi, Alberto, primary, Oudit, Deemesh, primary, Dhomen, Nathalie, primary, Brady, Ged, primary, Lorigan, Paul, primary, Dive, Caroline, primary, and Marais, Richard, primary

Published
2023
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43. Supplementary Figure Legends from Primary Melanoma of the CNS in Children Is Driven by Congenital Expression of Oncogenic NRAS in Melanocytes

Author

Pedersen, Malin, primary, Küsters-Vandevelde, Heidi V.N., primary, Viros, Amaya, primary, Groenen, Patricia J.T.A., primary, Sanchez-Laorden, Berta, primary, Gilhuis, Jacobus H., primary, van Engen-van Grunsven, Ilse A., primary, Renier, Willy, primary, Schieving, Jolanda, primary, Niculescu-Duvaz, Ion, primary, Springer, Caroline J., primary, Küsters, Benno, primary, Wesseling, Pieter, primary, Blokx, Willeke A.M., primary, and Marais, Richard, primary

Published
2023
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44. Supplementary Figure 2 from Primary Melanoma of the CNS in Children Is Driven by Congenital Expression of Oncogenic NRAS in Melanocytes

Author

Pedersen, Malin, primary, Küsters-Vandevelde, Heidi V.N., primary, Viros, Amaya, primary, Groenen, Patricia J.T.A., primary, Sanchez-Laorden, Berta, primary, Gilhuis, Jacobus H., primary, van Engen-van Grunsven, Ilse A., primary, Renier, Willy, primary, Schieving, Jolanda, primary, Niculescu-Duvaz, Ion, primary, Springer, Caroline J., primary, Küsters, Benno, primary, Wesseling, Pieter, primary, Blokx, Willeke A.M., primary, and Marais, Richard, primary

Published
2023
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45. Supplementary Figure 5 from Primary Melanoma of the CNS in Children Is Driven by Congenital Expression of Oncogenic NRAS in Melanocytes

Author

Pedersen, Malin, primary, Küsters-Vandevelde, Heidi V.N., primary, Viros, Amaya, primary, Groenen, Patricia J.T.A., primary, Sanchez-Laorden, Berta, primary, Gilhuis, Jacobus H., primary, van Engen-van Grunsven, Ilse A., primary, Renier, Willy, primary, Schieving, Jolanda, primary, Niculescu-Duvaz, Ion, primary, Springer, Caroline J., primary, Küsters, Benno, primary, Wesseling, Pieter, primary, Blokx, Willeke A.M., primary, and Marais, Richard, primary

Published
2023
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46. Supplementary Figure S1 from Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma

Author

Girotti, Maria R., primary, Pedersen, Malin, primary, Sanchez-Laorden, Berta, primary, Viros, Amaya, primary, Turajlic, Samra, primary, Niculescu-Duvaz, Dan, primary, Zambon, Alfonso, primary, Sinclair, John, primary, Hayes, Andrew, primary, Gore, Martin, primary, Lorigan, Paul, primary, Springer, Caroline, primary, Larkin, James, primary, Jorgensen, Claus, primary, and Marais, Richard, primary

Published
2023
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47. Supplementary Methods from Application of Sequencing, Liquid Biopsies, and Patient-Derived Xenografts for Personalized Medicine in Melanoma

Author

Girotti, Maria Romina, primary, Gremel, Gabriela, primary, Lee, Rebecca, primary, Galvani, Elena, primary, Rothwell, Dominic, primary, Viros, Amaya, primary, Mandal, Amit Kumar, primary, Lim, Kok Haw Jonathan, primary, Saturno, Grazia, primary, Furney, Simon J., primary, Baenke, Franziska, primary, Pedersen, Malin, primary, Rogan, Jane, primary, Swan, Jacqueline, primary, Smith, Matthew, primary, Fusi, Alberto, primary, Oudit, Deemesh, primary, Dhomen, Nathalie, primary, Brady, Ged, primary, Lorigan, Paul, primary, Dive, Caroline, primary, and Marais, Richard, primary

Published
2023
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48. Supplementary Figure 1 from Primary Melanoma of the CNS in Children Is Driven by Congenital Expression of Oncogenic NRAS in Melanocytes

Author

Pedersen, Malin, primary, Küsters-Vandevelde, Heidi V.N., primary, Viros, Amaya, primary, Groenen, Patricia J.T.A., primary, Sanchez-Laorden, Berta, primary, Gilhuis, Jacobus H., primary, van Engen-van Grunsven, Ilse A., primary, Renier, Willy, primary, Schieving, Jolanda, primary, Niculescu-Duvaz, Ion, primary, Springer, Caroline J., primary, Küsters, Benno, primary, Wesseling, Pieter, primary, Blokx, Willeke A.M., primary, and Marais, Richard, primary

Published
2023
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49. Supplementary Material from Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma

Author

Girotti, Maria R., primary, Pedersen, Malin, primary, Sanchez-Laorden, Berta, primary, Viros, Amaya, primary, Turajlic, Samra, primary, Niculescu-Duvaz, Dan, primary, Zambon, Alfonso, primary, Sinclair, John, primary, Hayes, Andrew, primary, Gore, Martin, primary, Lorigan, Paul, primary, Springer, Caroline, primary, Larkin, James, primary, Jorgensen, Claus, primary, and Marais, Richard, primary

Published
2023
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50. Supplementary Figure 3 from Primary Melanoma of the CNS in Children Is Driven by Congenital Expression of Oncogenic NRAS in Melanocytes

Author

Pedersen, Malin, primary, Küsters-Vandevelde, Heidi V.N., primary, Viros, Amaya, primary, Groenen, Patricia J.T.A., primary, Sanchez-Laorden, Berta, primary, Gilhuis, Jacobus H., primary, van Engen-van Grunsven, Ilse A., primary, Renier, Willy, primary, Schieving, Jolanda, primary, Niculescu-Duvaz, Ion, primary, Springer, Caroline J., primary, Küsters, Benno, primary, Wesseling, Pieter, primary, Blokx, Willeke A.M., primary, and Marais, Richard, primary

Published
2023
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