147,190 results on '"A. Vernon"'
Search Results
2. Teacher Salary Raises and Turnover: Evidence from the First Year of the Arkansas LEARNS Act. EdWorkingPaper No. 24-972
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Annenberg Institute for School Reform at Brown University, University of Arkansas, Department of Education Reform, Arkansas Department of Education, Gema Zamarro, Andrew Camp, Josh McGee, Taylor Wilson, and Miranda Vernon
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Attracting and retaining high-quality teachers is a pressing policy concern. Increasing teacher salaries and creating more attractive compensation packages are often proposed as a potential solution. Signed into law in March 2023, the LEARNS Act increased Arkansas's minimum teacher salary from $36,000 to $50,000, guaranteed all teachers a minimum raise of $2,000, and added flexibility allowing school districts to deviate from seniority-based traditional salary schedules. To study school districts' adjustments to the new legislation, we collected information about districts' teacher compensation policies one year before and the first year of implementation. We also integrated this data with teachers' administrative records to study patterns of teacher retention and mobility. Our results reveal a more equitable distribution of starting teacher salaries across districts, with minimal variation. The LEARNS Act notably increased funding for rural and high-poverty districts, mitigating the negative association between starting salaries and district poverty rates. However, the initial effects on teacher retention and mobility were modest. While some positive trends emerged, such as reduced probabilities of teachers transitioning to non-instructional roles and increased new teacher placement in geographic areas of shortage, broader impacts on retention and mobility were limited in the first year of implementation.
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- 2024
3. Barriers and facilitators to continuous quality improvement engagement among rural physicians in British Columbia, Canada: A mixed-methods study
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Born, Dawson, Lynn, Brenna M, Bluman, Bob, Markham, Ray, and Curran, Vernon
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- 2024
4. Spectrum Analysis with the Prime Factor Algorithm on Embedded Systems
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Vernon, Josh and Perera, D. G.
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Computer Science - Hardware Architecture - Abstract
This paper details the purpose, difficulties, theory, implementation, and results of developing a Fast Fourier Transform (FFT) using the prime factor algorithm on an embedded system. Many applications analyze the frequency content of signals, which is referred to as spectral analysis. Some of these applications include communication systems, radar systems, control systems, seismology, speech, music, sonar, finance, image processing, and neural networks. For many real-time applications, the speed at which the spectral analysis is performed is crucial. In order to perform spectral analysis, a Fourier transform is employed. For embedded systems, where spectral analysis is done digitally, a discrete Fourier transform (DFT) is employed. The main goal for this project is to develop an FFT for a 36-point DFT on the Nuvoton Nu-LB-NUC140V2. In this case, the prime factor algorithm is utilized to compute a fast DFT., Comment: 15 pages, 8 Figures
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- 2025
5. Nesterov Acceleration for Ensemble Kalman Inversion and Variants
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Vernon, Sydney, Bach, Eviatar, and Dunbar, Oliver R. A.
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Mathematics - Optimization and Control ,Computer Science - Machine Learning ,Statistics - Computation - Abstract
Ensemble Kalman inversion (EKI) is a derivative-free, particle-based optimization method for solving inverse problems. It can be shown that EKI approximates a gradient flow, which allows the application of methods for accelerating gradient descent. Here, we show that Nesterov acceleration is effective in speeding up the reduction of the EKI cost function on a variety of inverse problems. We also implement Nesterov acceleration for two EKI variants, unscented Kalman inversion and ensemble transform Kalman inversion. Our specific implementation takes the form of a particle-level nudge that is demonstrably simple to couple in a black-box fashion with any existing EKI variant algorithms, comes with no additional computational expense, and with no additional tuning hyperparameters. This work shows a pathway for future research to translate advances in gradient-based optimization into advances in gradient-free Kalman optimization.
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- 2025
6. Performance Optimization of Ratings-Based Reinforcement Learning
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Rose, Evelyn, White, Devin, Wu, Mingkang, Lawhern, Vernon, Waytowich, Nicholas R., and Cao, Yongcan
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence - Abstract
This paper explores multiple optimization methods to improve the performance of rating-based reinforcement learning (RbRL). RbRL, a method based on the idea of human ratings, has been developed to infer reward functions in reward-free environments for the subsequent policy learning via standard reinforcement learning, which requires the availability of reward functions. Specifically, RbRL minimizes the cross entropy loss that quantifies the differences between human ratings and estimated ratings derived from the inferred reward. Hence, a low loss means a high degree of consistency between human ratings and estimated ratings. Despite its simple form, RbRL has various hyperparameters and can be sensitive to various factors. Therefore, it is critical to provide comprehensive experiments to understand the impact of various hyperparameters on the performance of RbRL. This paper is a work in progress, providing users some general guidelines on how to select hyperparameters in RbRL., Comment: Accepted to the Collaborative AI and Modeling of Humans Bridge Program at AAAI 2025
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- 2025
7. RbRL2.0: Integrated Reward and Policy Learning for Rating-based Reinforcement Learning
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Wu, Mingkang, White, Devin, Lawhern, Vernon, Waytowich, Nicholas R., and Cao, Yongcan
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence - Abstract
Reinforcement learning (RL), a common tool in decision making, learns policies from various experiences based on the associated cumulative return/rewards without treating them differently. On the contrary, humans often learn to distinguish from different levels of performance and extract the underlying trends towards improving their decision making for best performance. Motivated by this, this paper proposes a novel RL method that mimics humans' decision making process by differentiating among collected experiences for effective policy learning. The main idea is to extract important directional information from experiences with different performance levels, named ratings, so that policies can be updated towards desired deviation from these experiences with different ratings. Specifically, we propose a new policy loss function that penalizes distribution similarities between the current policy and failed experiences with different ratings, and assign different weights to the penalty terms based on the rating classes. Meanwhile, reward learning from these rated samples can be integrated with the new policy loss towards an integrated reward and policy learning from rated samples. Optimizing the integrated reward and policy loss function will lead to the discovery of directions for policy improvement towards maximizing cumulative rewards and penalizing most from the lowest performance level while least from the highest performance level. To evaluate the effectiveness of the proposed method, we present results for experiments on a few typical environments that show improved convergence and overall performance over the existing rating-based reinforcement learning method with only reward learning., Comment: Accepted to the Collaborative AI and Modeling of Humans Bridge Program at AAAI 2025
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- 2025
8. Non-linear bistability in pulsed optical traps
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Vernon, Alex J., Rodríguez-Fortuño, Francisco J., and Zayats, Anatoly V.
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Physics - Optics - Abstract
Optical trapping, also known as optical tweezing or optical levitation, is a technique that uses highly focused laser beams to manipulate micro- and nanoscopic particles. In optical traps driven by high-energy pulses, material non-linearity can result in unusual opto-mechanical effects, such as displaced equilibrium points. However, existing theoretical models of non-linear optical force on small particles consider smooth material dependence on the incident field strength alone, and not the feedback between the particle permittivity and internal field strength, which is, in turn, a function of the permittivity. The hysteresis effects of optical bistability in pulsed optical traps therefore elude existing optical force models. Here, we investigate a bistable optical trap, set up by counter-propagating ultrashort pulses, in which the optical force exerted on a particle depends not only on the field at the particle's current location, but on the particle's historic trajectory in the trap. The developed formalism will be important for designing optical traps and nanoparticle manipulation in pulsed field for various applications, including potentially time crystal demonstrations.
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- 2025
9. Spectroscopic and X-ray Modeling of the Strong Lensing Galaxy Cluster MACS J0138.0-2155
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Flowers, Abigail, O'Donnell, Jackson H., Jeltema, Tesla E., Wetzell, Vernon, and Roberts, M. Grant
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We model the total mass and galactic substructure in the strong lensing galaxy cluster MACS J0138.0-2155 using a combination of Chandra X-ray data, Multi-Unit Spectroscopic Explorer (MUSE) spectroscopy, and Hubble Space Telescope imaging. MACS J0138.0-2155 lenses a source galaxy at z=1.95 which hosts two strongly lensed supernovae, Requiem and Encore. We find MACS J0138.0-2155 to have an X-ray temperature of 6.7 +/- 0.4 keV and a velocity dispersion of cluster member galaxies of 718^{+132}_{-182} km/s, which indicate a cluster mass of ~5 x 10^{14} solar masses. The round morphology of the X-ray emission indicates that this cluster is relaxed with an ellipticity within the lensing region of e=0.12 +/- 0.03. Using 18 of the brightest, non-blended, quiescent galaxies, we fit the cluster specific Faber-Jackson relation, including a set of 81 variations in the analysis choices to estimate the systematic uncertainties in our results. We find a slope of alpha = 0.26 +/- 0.06 (stat.) +/- 0.03 (sys.) with an intrinsic scatter of 31^{+8}_{-6} (stat.) +/- 4 (sys.) km/s at a reference velocity dispersion of ~220 km/s. We also report on significant galaxies along the line-of-sight potentially impacting the lens modeling, including a massive galaxy with stellar velocity dispersion of 291 +/- 3 km/s$ which lies close in projection to the central cluster galaxy. This galaxy is part of a small group at a slightly higher redshift than the cluster., Comment: submitted to Open Journal of Astrophysics
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- 2024
10. Implications of Higgs mass for hidden sector SUSY breaking
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Baer, Howard, Barger, Vernon, Bolich, Jessica, and Zhang, Kairui
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High Energy Physics - Phenomenology - Abstract
Hidden sector SUSY breaking where charged hidden sector fields obtain SUSY breaking vevs once seemed common in dynamical SUSY breaking (DSB). In such a case, scalars can obtain large masses but gauginos and A-terms gain loop-suppressed anomaly-mediated contributions which may be smaller by factors of 1/16\pi^2 ~1/160. This situation leads to models such as PeV or mini-split supersymmetry with m(scalars)~ 160 m(gauginos). In order to generate a light Higgs mass m_h~ 125 GeV, the scalar mass terms are required in the 10-100 TeV range, leading to large, unnatural contributions to the weak scale. Alternatively, in gravity mediation with singlet hidden sector fields, then m(scalars)~ m(gauginos)~ A-terms and the large A-terms lift m_h ->125 GeV even for natural values of m(stop1)~ 1-3 TeV. Requiring naturalness, which is probabilistically preferred by the string landscape, then the measured Higgs mass seems to favor singlets in the hidden sector, which can be common in metastable and retrofitted DSB models., Comment: 18 pages with 8 .png figures
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- 2024
11. Stabilizing Reinforcement Learning in Differentiable Multiphysics Simulation
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Xing, Eliot, Luk, Vernon, and Oh, Jean
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Robotics - Abstract
Recent advances in GPU-based parallel simulation have enabled practitioners to collect large amounts of data and train complex control policies using deep reinforcement learning (RL), on commodity GPUs. However, such successes for RL in robotics have been limited to tasks sufficiently simulated by fast rigid-body dynamics. Simulation techniques for soft bodies are comparatively several orders of magnitude slower, thereby limiting the use of RL due to sample complexity requirements. To address this challenge, this paper presents both a novel RL algorithm and a simulation platform to enable scaling RL on tasks involving rigid bodies and deformables. We introduce Soft Analytic Policy Optimization (SAPO), a maximum entropy first-order model-based actor-critic RL algorithm, which uses first-order analytic gradients from differentiable simulation to train a stochastic actor to maximize expected return and entropy. Alongside our approach, we develop Rewarped, a parallel differentiable multiphysics simulation platform that supports simulating various materials beyond rigid bodies. We re-implement challenging manipulation and locomotion tasks in Rewarped, and show that SAPO outperforms baselines over a range of tasks that involve interaction between rigid bodies, articulations, and deformables.
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- 2024
12. Emma-X: An Embodied Multimodal Action Model with Grounded Chain of Thought and Look-ahead Spatial Reasoning
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Sun, Qi, Hong, Pengfei, Pala, Tej Deep, Toh, Vernon, Tan, U-Xuan, Ghosal, Deepanway, and Poria, Soujanya
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Computer Science - Robotics ,Computer Science - Artificial Intelligence ,Computer Science - Computation and Language ,Computer Science - Computer Vision and Pattern Recognition - Abstract
Traditional reinforcement learning-based robotic control methods are often task-specific and fail to generalize across diverse environments or unseen objects and instructions. Visual Language Models (VLMs) demonstrate strong scene understanding and planning capabilities but lack the ability to generate actionable policies tailored to specific robotic embodiments. To address this, Visual-Language-Action (VLA) models have emerged, yet they face challenges in long-horizon spatial reasoning and grounded task planning. In this work, we propose the Embodied Multimodal Action Model with Grounded Chain of Thought and Look-ahead Spatial Reasoning, Emma-X. Emma-X leverages our constructed hierarchical embodiment dataset based on BridgeV2, containing 60,000 robot manipulation trajectories auto-annotated with grounded task reasoning and spatial guidance. Additionally, we introduce a trajectory segmentation strategy based on gripper states and motion trajectories, which can help mitigate hallucination in grounding subtask reasoning generation. Experimental results demonstrate that Emma-X achieves superior performance over competitive baselines, particularly in real-world robotic tasks requiring spatial reasoning., Comment: https://github.com/declare-lab/Emma-X, https://huggingface.co/declare-lab/Emma-X
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- 2024
13. Assessing the Role of Volumetric Brain Information in Multiple Sclerosis Progression
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Shen, Andy A., McLoughlin, Aidan, Vernon, Zoe, Lin, Jonathan, Carano, Richard A. D., Bickel, Peter J., Song, Zhuang, and Huang, Haiyan
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Statistics - Applications - Abstract
Multiple sclerosis is a chronic autoimmune disease that affects the central nervous system. Understanding multiple sclerosis progression and identifying the implicated brain structures is crucial for personalized treatment decisions. Deformation-based morphometry utilizes anatomical magnetic resonance imaging to quantitatively assess volumetric brain changes at the voxel level, providing insight into how each brain region contributes to clinical progression with regards to neurodegeneration. Utilizing such voxel-level data from a relapsing multiple sclerosis clinical trial, we extend a model-agnostic feature importance metric to identify a robust and predictive feature set that corresponds to clinical progression. These features correspond to brain regions that are clinically meaningful in MS disease research, demonstrating their scientific relevance. When used to predict progression using classical survival models and 3D convolutional neural networks, the identified regions led to the best-performing models, demonstrating their prognostic strength. We also find that these features generalize well to other definitions of clinical progression and can compensate for the omission of highly prognostic clinical features, underscoring the predictive power and clinical relevance of deformation-based morphometry as a regional identification tool.
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- 2024
14. Course Correction: Navigating Equity in Ninth-Grade Advanced Placement
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Sarah R. Morris, Sarah C. McKenzie, and Miranda G. Vernon
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This robust mixed-methods study examines ninth-grade advanced course placement in Arkansas, revealing disparities rooted in race and socioeconomic status. Utilizing a logit analysis for a five-year pooled sample (n = 163,616), we find persistent enrollment gaps for Black ninth-grade students after controlling for prior academic achievement, highlighting systemic barriers to access to advanced courses. Socioeconomic divides are also evident in our analysis. Qualitative findings from counselor interviews highlight the importance of parental involvement in course placement decisions, particularly for students from lower socioeconomic backgrounds. Overall, we find through these interviews that districts consider a myriad of factors when considering course placement for ninth-grade courses. We recommend systemic changes for districts, including local norm-based placement systems and automatic enrollment policies to enhance fairness in advanced course placement.
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- 2025
- Full Text
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15. ZIC1 is a context-dependent medulloblastoma driver in the rhombic lip.
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Lee, John, Tao, Ran, You, Zhen, Haldipur, Parthiv, Erickson, Anders, Farooq, Hamza, Hendriske, Liam, Abeysundara, Namal, Richman, Cory, Wang, Evan, Das Gupta, Neha, Hadley, Jennifer, Batts, Melissa, Mount, Christopher, Wu, Xiaochong, Rasnitsyn, Alex, Bailey, Swneke, Cavalli, Florence, Morrissy, Sorana, Garzia, Livia, Michealraj, Kulandaimanuvel, Visvanathan, Abhi, Fong, Vernon, Palotta, Jonelle, Suarez, Raul, Livingston, Bryn, Liu, Miao, Luu, Betty, Daniels, Craig, Loukides, James, Bendel, Anne, French, Pim, Kros, Johan, Korshunov, Andrey, Kool, Marcel, Chico Ponce de León, Fernando, Perezpeña-Diazconti, Mario, Lach, Boleslaw, Singh, Sheila, Leary, Sarah, Cho, Byung-Kyu, Kim, Seung-Ki, Wang, Kyu-Chang, Lee, Ji-Yeoun, Tominaga, Teiji, Weiss, William, Phillips, Joanna, Dai, Shizhong, Zadeh, Gelareh, Saad, Ali, Bognár, László, Klekner, Almos, Pollack, Ian, Hamilton, Ronald, Ra, Young-Shin, Grajkowska, Wieslawa, Perek-Polnik, Marta, Thompson, Reid, Kenney, Anna, Cooper, Michael, Mack, Stephen, Jabado, Nada, Lupien, Mathieu, Gallo, Marco, Ramaswamy, Vijay, Suva, Mario, Suzuki, Hiromichi, Millen, Kathleen, Huang, L, Northcott, Paul, and Taylor, Michael
- Abstract
Transcription factors are frequent cancer driver genes, exhibiting noted specificity based on the precise cell of origin. We demonstrate that ZIC1 exhibits loss-of-function (LOF) somatic events in group 4 (G4) medulloblastoma through recurrent point mutations, subchromosomal deletions and mono-allelic epigenetic repression (60% of G4 medulloblastoma). In contrast, highly similar SHH medulloblastoma exhibits distinct and diametrically opposed gain-of-function mutations and copy number gains (20% of SHH medulloblastoma). Overexpression of ZIC1 suppresses the growth of group 3 medulloblastoma models, whereas it promotes the proliferation of SHH medulloblastoma precursor cells. SHH medulloblastoma ZIC1 mutants show increased activity versus wild-type ZIC1, whereas G4 medulloblastoma ZIC1 mutants exhibit LOF phenotypes. Distinct ZIC1 mutations affect cells of the rhombic lip in diametrically opposed ways, suggesting that ZIC1 is a critical developmental transcriptional regulator in both the normal and transformed rhombic lip and identifying ZIC1 as an exquisitely context-dependent driver gene in medulloblastoma.
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- 2025
16. Stage at diagnosis and cancer-specific survival for stomach, lung, colorectal, and bladder cancers among Armenians in California
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Movsisyan Vernon, Ani S, Fejerman, Laura, Hoch, Jeffrey S, and Keegan, Theresa H
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Epidemiology ,Public Health ,Health Sciences ,Colo-Rectal Cancer ,Lung ,Cancer ,Behavioral and Social Science ,Digestive Diseases ,Clinical Research ,Armenia ,California ,Early detection ,Insurance ,Stage ,Survival ,Human Movement and Sports Sciences ,Public Health and Health Services ,Public health - Abstract
ObjectiveTo observe stage at diagnosis and cancer-specific survival for common cancers among Armenians in California.MethodsWe used the Armenian Surname List and birthplace information in the California Cancer Registry to identify Armenians with stomach, lung, colorectal, and bladder cancers diagnosed during 1988-2019. We used multivariable logistic regression models to calculate odds of late-stage diagnoses among Armenian and non-Armenian, non-Hispanic White patients and examine the association of sociodemographic factors with late-stage diagnoses among the Armenian patient population. We used Cox proportional hazards models to calculate cancer-specific survival among Armenian patients compared to non-Armenian, non-Hispanic White patients.ResultsOf the 639,224 cancer diagnoses identified, 6642 were among Armenian patients. Armenian individuals were more likely to be diagnosed with late-stage colorectal (OR = 1.12, 95 % CI = 1.03-1.22), lung (OR = 1.26, 95 % CI = 1.12-1.42), and stomach (OR = 1.43, 95 % CI = 1.17-1.74) cancers. Among Armenian patients, low nSES and public insurance were associated with late-stage diagnoses. Armenian individuals had better survival than non-Armenian, non-Hispanic White individuals for stomach (HR = 0.85, 95 % CI = 0.76-0.94), lung (HR = 0.86, 95 % CI = 0.82-0.91), colorectal (HR = 0.82, 95 % CI = 0.77-0.88), and bladder (HR = 0.87, 95 % CI = 0.76-0.99) cancers.ConclusionWhile Armenian patients were at greater risk of late-stage diagnoses of colorectal, lung, and stomach cancers, they had better survival compared to non-Armenian, non-Hispanic White patients. Further research is needed to understand factors impacting survival in Armenian individuals, including genetic, behavioral, and social factors. Our findings of lower nSES and public health insurance associated with late-stage diagnoses suggest a need for increased access to care and cancer screening among the Armenian population in California.
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- 2024
17. Living dangerously with decoupled first/second generation scalars: SUSY prospects at the LHC
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Baer, Howard, Barger, Vernon, and Zhang, Kairui
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High Energy Physics - Phenomenology ,High Energy Physics - Theory - Abstract
The string landscape statistical draw to large scalar soft masses leads to a mixed quasi-degeneracy/decoupling solution to the SUSY flavor and CP problems where first/second generation matter scalars lie in the 20-40 TeV range. With increasing first/second generation scalars, SUSY models actually become more natural due to two-loop RG effects which suppress the corresponding third generation soft masses. This can also lead to substantial parameter space regions which are forbidden by the presence of charge and/or color breaking (CCB) minima of the scalar potential. We outline the allowed SUSY parameter space for the gravity-mediated three extra-parameter-non-universal Higgs model NUHM3. The natural regions with m_h~ 125 GeV, \Delta_{EW}<~ 30 and decoupled first/second generation scalar are characterized by rather heavy gluinos and EW gauginos, but with rather small \mu and top-squarks not far beyond LHC Run 2 limits. This scenario also explains why SUSY has so far eluded discovery at LHC in that the parameter space with small scalar and gaugino masses is all excluded by the presence of CCB minima., Comment: 18 pages with 11 .png figures
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- 2024
18. Electromagnetic symmetry dislocations
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Vernon, Alex J., Golat, Sebastian, and Rodríguez-Fortuño, Francisco J.
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Physics - Optics - Abstract
Singular optics aims to understand and manipulate light's topological defects, pioneered by the discovery that phase vortex lines, strands of destructive interference, naturally occur in scalar wave fields. Monochromatic electromagnetic fields, however, are described by complex three-dimensional vectors that make individual scalar phase vortices in their vector components, which depend on the choice of co-ordinate basis, less meaningful. Instead, polarisation singularities can capture the vector texture of complicated, even non-paraxial light, with separate spatial descriptions for the electric $\mathbf{E}$ and magnetic $\mathbf{H}$ fields. But polarisation textures, too, are basis-dependent, because the laws of electromagnetism can be expressed not only by separate $\mathbf{E}$ and $\mathbf{H}$ fields, but by linear combinations of the two. We instead propose fundamental, basis-independent topological features generic in monochromatic electromagnetic fields: one- and two-dimensional structures that relate to time-averaged symmetries, including parity, duality and time-reversal, held locally by the combined electric and magnetic field polarisation geometry.
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- 2024
19. Cortical Dynamics of Neural-Connectivity Fields
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Cooray, Gerald K., Cooray, Vernon, and Friston, Karl J.
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Quantitative Biology - Neurons and Cognition - Abstract
Macroscopic studies of cortical tissue reveal a prevalence of oscillatory activity, that reflect a fine tuning of neural interactions. This research extends neural field theories by incorporating generalized oscillatory dynamics into previous work on conservative or semi-conservative neural field dynamics. Prior studies have largely assumed isotropic connections among neural units; however, this study demonstrates that a broad range of anisotropic and fluctuating connections can still sustain oscillations. Using Lagrangian field methods, we examine different types of connectivity, their dynamics, and potential interactions with neural fields. From this theoretical foundation, we derive a framework that incorporates Hebbian and non-Hebbian learning, i.e., plasticity, into the study of neural fields via the concept of a connectivity field., Comment: 31 pages, 4 figures
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- 2024
20. Not All Votes Count! Programs as Verifiers Improve Self-Consistency of Language Models for Math Reasoning
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Toh, Vernon Y. H., Ghosal, Deepanway, and Poria, Soujanya
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Computer Science - Computation and Language - Abstract
Large language models (LLMs) have shown increasing competence in solving mathematical reasoning problems. However, many open-source LLMs still struggle with errors in calculation and semantic understanding during intermediate reasoning steps. In this work, we introduce Prove, a simple yet effective framework that leverages translated programs derived from natural language solutions as a verification mechanism to filter out potentially incorrect reasoning paths before aggregating final answers. Unlike vanilla majority voting, our approach filters out solutions whose corresponding program output is inconsistent with the generated solution, aggregating only those that pass verification. We conducted extensive experiments using 13 open-source LLMs from various model families and sizes, ranging from 0.5B to 13B parameters, across eight mathematical benchmarks. Our results show that Prove consistently outperforms vanilla majority voting as a heuristic for solving mathematical reasoning tasks across all model sizes and datasets, achieving improvements of up to 18% on GSM8K and 8% on MATH-500. Our codes are available at https://github.com/declare-lab/prove.
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- 2024
21. Socialization, Education, and Learning for the Internet (SELFI): A Pilot RCT of a Social Media Skills Group Program for Autistic Adults
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Anthony Osuna, Katie Sabini, Eryca Yamane, Jaqueline Flores, Naomi Pierce, Jocelyn Lemus-Valle, and Ty Vernon
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Many autistic adults report preference for computer-mediated communication and social media use. Despite many benefits to online socialization, there are many challenges including anxiety and cyber-victimization. To date, support is limited related to helping autistic adults with safe and effective internet use. The purpose of this study was to evaluate the feasibility, acceptability, and preliminary efficacy of the novel SELFI program. This pilot study utilized a randomized controlled trial design. A total of 25 autistic adults enrolled in the study and were randomized to the nine-week SELFI program or a waitlist control condition. Feasibility assessed enrollment, attrition, and fidelity of delivery. Acceptability examined attendance and feedback from participants and peer mentors. Efficacy evaluated change in Facebook activity, social media utility/anxiety, and individualized goals. Regarding feasibility, the recruitment goal was met within one month, there was limited attrition, and therapists delivered the program with high fidelity. Participants attended a majority of scheduled sessions and feedback from participants reflected high levels of agreement with several facets of the program. Compared to the control group, more participants assigned to the SELFI condition were perceived by autistic and non-autistic raters as having improved Facebook activity. SELFI participants also reported reduced difficulty meeting their individualized goal. Findings support the piloted SELFI program as feasible and acceptable with signals of preliminary efficacy. This study establishes an exciting foundation regarding an innovative social media skills program, however more research is necessary.
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- 2024
- Full Text
- View/download PDF
22. Risk-stratified treatment for drug-susceptible pulmonary tuberculosis
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Chang, Vincent K, Imperial, Marjorie Z, Phillips, Patrick PJ, Velásquez, Gustavo E, Nahid, Payam, Vernon, Andrew, Kurbatova, Ekaterina V, Swindells, Susan, Chaisson, Richard E, Dorman, Susan E, Johnson, John L, Weiner, Marc, Sizemore, Erin E, Whitworth, William, Carr, Wendy, Bryant, Kia E, Burton, Deron, Dooley, Kelly E, Engle, Melissa, Nsubuga, Pheona, Diacon, Andreas H, Nhung, Nguyen Viet, Dawson, Rodney, and Savic, Radojka M
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Biomedical and Clinical Sciences ,Clinical Sciences ,Emerging Infectious Diseases ,Infectious Diseases ,Patient Safety ,Clinical Research ,Tuberculosis ,Prevention ,Rare Diseases ,Clinical Trials and Supportive Activities ,Lung ,Orphan Drug ,6.1 Pharmaceuticals ,Infection ,Good Health and Well Being ,Humans ,Rifampin ,Tuberculosis ,Pulmonary ,Male ,Female ,Adult ,Middle Aged ,Antitubercular Agents ,Moxifloxacin ,Risk Factors ,Treatment Outcome ,Mycobacterium tuberculosis ,Drug Therapy ,Combination ,Young Adult ,AIDS Clinical Trial Group ,Tuberculosis Trials Consortium - Abstract
The Phase 3 randomized controlled trial, TBTC Study 31/ACTG A5349 (NCT02410772) demonstrated that a 4-month rifapentine-moxifloxacin regimen for drug-susceptible pulmonary tuberculosis was safe and effective. The primary efficacy outcome was 12-month tuberculosis disease free survival, while the primary safety outcome was the proportion of grade 3 or higher adverse events during the treatment period. We conducted an analysis of demographic, clinical, microbiologic, radiographic, and pharmacokinetic data and identified risk factors for unfavorable outcomes and adverse events. Among participants receiving the rifapentine-moxifloxacin regimen, low rifapentine exposure is the strongest driver of tuberculosis-related unfavorable outcomes (HR 0.65 for every 100 µg∙h/mL increase, 95%CI 0.54-0.77). The only other risk factors identified are markers of higher baseline disease severity, namely Xpert MTB/RIF cycle threshold and extent of disease on baseline chest radiography (Xpert: HR 1.43 for every 3-cycle-threshold decrease, 95%CI 1.07-1.91; extensive disease: HR 2.02, 95%CI 1.07-3.82). From these risk factors, we developed a simple risk stratification to classify disease phenotypes as easier-, moderately-harder, or harder-to-treat TB. Notably, high rifapentine exposures are not associated with any predefined adverse safety outcomes. Our results suggest that the easier-to-treat subgroup may be eligible for further treatment shortening while the harder-to-treat subgroup may need higher doses or longer treatment.
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- 2024
23. Investigating Complex HPV Dynamics Using Emulation and History Matching
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Iskauskas, Andrew, Cohen, Jamie A., Scarponi, Danny, Vernon, Ian, Goldstein, Michael, Klein, Daniel, White, Richard G., and McCreesh, Nicky
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Statistics - Applications ,Statistics - Computation - Abstract
The study of transmission and progression of human papillomavirus (HPV) is crucial for understanding the incidence of cervical cancers, and has been identified as a priority worldwide. The complexity of the disease necessitates a detailed model of HPV transmission and its progression to cancer; to infer properties of the above we require a careful process that can match to imperfect or incomplete observational data. In this paper, we describe the HPVsim simulator to satisfy the former requirement; to satisfy the latter we couple this stochastic simulator to a process of emulation and history matching using the R package hmer. With these tools, we are able to obtain a comprehensive collection of parameter combinations that could give rise to observed cancer data, and explore the implications of the variability of these parameter sets as it relates to future health interventions., Comment: 21 pages, 15 figures; submitted to Epidemics
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- 2024
24. Ionization potential of radium monofluoride
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Wilkins, S. G., Perrett, H. A., Udrescu, S. M., Kyuberis, A. A., Pašteka, L. F., Au, M., Belošević, I., Berger, R., Binnersley, C. L., Bissell, M. L., Borschevsky, A., Breier, A. A., Brinson, A. J., Chrysalidis, K., Cocolios, T. E., Cooper, B. S., de Groote, R. P., Dorne, A., Eliav, E., Field, R. W., Flanagan, K. T., Franchoo, S., Ruiz, R. F. Garcia, Gaul, K., Geldhof, S., Giesen, T. F., Gustafsson, F. P., Hanstorp, D., Heinke, R., Koszorús, Á., Kujanpää, S., Lalanne, L., Neyens, G., Nichols, M., Reilly, J. R., Ricketts, C. M., Rothe, S., Sunaga, A., Borne, B. van den, Vernon, A. R., Wang, Q., Wessolek, J., Wienholtz, F., Yang, X. F., Zhou, Y., and Zülch, C.
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Physics - Atomic Physics ,Nuclear Experiment ,Physics - Chemical Physics ,Physics - Computational Physics - Abstract
The ionization potential (IP) of radium monofluoride (RaF) was measured to be 4.969(2)[10] eV, revealing a relativistic enhancement in the series of alkaline earth monofluorides. The results are in agreement with a relativistic coupled-cluster prediction of 4.969[7] eV, incorporating up to quantum electrodynamics corrections. Using the same computational methodology, an improved calculation for the dissociation energy ($D_{0}$) of 5.54[5] eV is presented. This confirms that radium monofluoride joins the small group of diatomic molecules for which $D_{0}>\mathrm{IP}$, paving the way for precision control and interrogation of its Rydberg states.
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- 2024
25. Ferret: Faster and Effective Automated Red Teaming with Reward-Based Scoring Technique
- Author
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Pala, Tej Deep, Toh, Vernon Y. H., Bhardwaj, Rishabh, and Poria, Soujanya
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Computer Science - Computation and Language - Abstract
In today's era, where large language models (LLMs) are integrated into numerous real-world applications, ensuring their safety and robustness is crucial for responsible AI usage. Automated red-teaming methods play a key role in this process by generating adversarial attacks to identify and mitigate potential vulnerabilities in these models. However, existing methods often struggle with slow performance, limited categorical diversity, and high resource demands. While Rainbow Teaming, a recent approach, addresses the diversity challenge by framing adversarial prompt generation as a quality-diversity search, it remains slow and requires a large fine-tuned mutator for optimal performance. To overcome these limitations, we propose Ferret, a novel approach that builds upon Rainbow Teaming by generating multiple adversarial prompt mutations per iteration and using a scoring function to rank and select the most effective adversarial prompt. We explore various scoring functions, including reward models, Llama Guard, and LLM-as-a-judge, to rank adversarial mutations based on their potential harm to improve the efficiency of the search for harmful mutations. Our results demonstrate that Ferret, utilizing a reward model as a scoring function, improves the overall attack success rate (ASR) to 95%, which is 46% higher than Rainbow Teaming. Additionally, Ferret reduces the time needed to achieve a 90% ASR by 15.2% compared to the baseline and generates adversarial prompts that are transferable i.e. effective on other LLMs of larger size. Our codes are available at https://github.com/declare-lab/ferret.
- Published
- 2024
26. Minding the gap: testing natural anomaly-mediated SUSY breaking at high luminosity LHC
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Baer, Howard, Barger, Vernon, Bolich, Jessica, Dutta, Juhi, and Sengupta, Dibyashree
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High Energy Physics - Phenomenology - Abstract
While the minimal anomaly-mediated SUSY breaking model (mAMSB) seems ruled out by constraints on Higgs mass, naturalness and wino dark matter, a slightly generalized version dubbed natural AMSB (nAMSB) remains both viable and compelling. Like mAMSB, nAMSB features winos as the lightest gauginos, but unlike mAMSB, nAMSB allows a small mu parameter so that higgsinos are the lightest of electroweakinos (EWinos). nAMSB spectra depend on the input value of gravitino mass m_{3/2}, where the lower range of m_{3/2} is excluded by LHC gluino pair searches while a higher m_{3/2} band is excluded by LHC limits on wino pair production followed by boosted hadronic wino decays. A remaining intermediate gap in m_{3/2} values remains allowed by present LHC searches, but appears to be completely explorable by high luminosity ugrades of LHC (HL-LHC). We explore a variety of compelling discovery channels that may allow one to close the intermediate gap in m_{3/2} values: 1. same-sign diboson +MET (SSdB) production arising from wino pair production, leading to same-sign dileptons plus MET, 2. trilepton production arising from wino pair production and 3. soft dilepton plus jet events from higgsino pair production, 4. top-squark pair production. From our signal-to-background analysis along a nAMSB model line, we expect HL-LHC to either discover or rule out the nAMSB model with 3000 fb^{-1} of integrated luminosity., Comment: 25 pages with 10 figures
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- 2024
27. Decoding the gaugino code, naturally, at high-lumi LHC
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Baer, Howard, Barger, Vernon, and Zhang, Kairui
- Subjects
High Energy Physics - Phenomenology ,High Energy Physics - Theory - Abstract
Natural supersymmetry with light higgsinos is most likely to emerge from the string landscape since the volume of scan parameter space shrinks to tiny volumes for electroweak unnatural models. Rather general arguments favor a landscape selection of soft SUSY breaking terms tilted to large values, but tempered by the atomic principle: that the derived value of the weak scale in each pocket universe lie not too far from its measured value in our universe. But that leaves (at least) three different paradigms for gaugino masses in natural SUSY models: unified (as in nonuniversal Higgs models), anomaly-mediation form (as in natural AMSB) and mirage mediation form (with comparable moduli- and anomaly-mediated contributions). We perform landscape scans for each of these, and show they populate different, but overlapping, positions in m(\ell\bar{\ell}) and m(wino) space. The first of these may be directly measurable at high-lumi LHC via the soft opposite-sign dilepton plus jets plus MET signature arising from higgsino pair production while the second of these could be extracted from direct wino pair production leading to same-sign diboson production., Comment: 17 pages with 3 .png figures
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- 2024
28. Integrating White and Black Box Techniques for Interpretable Machine Learning
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Vernon, Eric M., Masuyama, Naoki, and Nojima, Yusuke
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Computer Science - Machine Learning - Abstract
In machine learning algorithm design, there exists a trade-off between the interpretability and performance of the algorithm. In general, algorithms which are simpler and easier for humans to comprehend tend to show worse performance than more complex, less transparent algorithms. For example, a random forest classifier is likely to be more accurate than a simple decision tree, but at the expense of interpretability. In this paper, we present an ensemble classifier design which classifies easier inputs using a highly-interpretable classifier (i.e., white box model), and more difficult inputs using a more powerful, but less interpretable classifier (i.e., black box model)., Comment: This paper was presented at ICICT2024 and will be published in conference proceedings by Springer LNNS. ISSN: 2367-3370, Series
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- 2024
29. VR-NRP: A Virtual Reality Simulation for Training in the Neonatal Resuscitation Program
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Aydin, Mustafa Yalin, Curran, Vernon, White, Susan, Pena-Castillo, Lourdes, and Meruvia-Pastor, Oscar
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Computer Science - Human-Computer Interaction ,Computer Science - Graphics ,I.3.8 ,I.6.3 - Abstract
The use of Virtual Reality (VR) technologies has been extensively researched in surgical and anatomical education. VR provides a lifelike and interactive environment where healthcare providers can practice and refresh their skills in a safe environment. VR has been shown to be as effective as traditional medical education teaching methods, with the potential to provide more cost-effective and convenient means of curriculum delivery, especially in rural and remote areas or in environments with limited access to hands-on training. In this sense, VR offers the potential to be used to support resuscitation training for healthcare providers such as the Neonatal Resuscitation Program (NRP). The NRP program is an evidence-based and standardized approach for training healthcare providers on the resuscitation of the newborn. In this article, we describe a VR simulation environment that was designed and developed to refresh the skills of NRP providers. To validate this platform, we compared the VR-NRP simulation with exposure to 360-degree immersive video. We found that both VR technologies were positively viewed by healthcare professionals and performed very similarly to each other. However, the VR simulation provided a significantly increased feeling of presence. Furthermore, participants found the VR simulation more useful, leading to improved experiential learning outcomes. Also, participants using VR simulation reported higher confidence in certain NRP skills, such as proper mask placement and newborn response evaluation. This research represents a step forward in understanding how VR and related extended reality (XR) technologies can be applied for effective, immersive medical education, with potential benefits for remote and rural healthcare providers.
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- 2024
30. Ruby Teaming: Improving Quality Diversity Search with Memory for Automated Red Teaming
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Han, Vernon Toh Yan, Bhardwaj, Rishabh, and Poria, Soujanya
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Computer Science - Computation and Language - Abstract
We propose Ruby Teaming, a method that improves on Rainbow Teaming by including a memory cache as its third dimension. The memory dimension provides cues to the mutator to yield better-quality prompts, both in terms of attack success rate (ASR) and quality diversity. The prompt archive generated by Ruby Teaming has an ASR of 74%, which is 20% higher than the baseline. In terms of quality diversity, Ruby Teaming outperforms Rainbow Teaming by 6% and 3% on Shannon's Evenness Index (SEI) and Simpson's Diversity Index (SDI), respectively.
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- 2024
31. Hierarchical Bayesian Emulation of the Expected Net Present Value Utility Function via a Multi-Model Ensemble Member Decomposition
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Owen, Jonathan and Vernon, Ian
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Statistics - Methodology ,Statistics - Applications - Abstract
Computer models are widely used to study complex real world physical systems. However, there are major limitations to their direct use including: their complex structure; large numbers of inputs and outputs; and long evaluation times. Bayesian emulators are an effective means of addressing these challenges providing fast and efficient statistical approximation for computer model outputs. It is commonly assumed that computer models behave like a ``black-box'' function with no knowledge of the output prior to its evaluation. This ensures that emulators are generalisable but potentially limits their accuracy compared with exploiting such knowledge of constrained or structured output behaviour. We assume a ``grey-box'' computer model and establish a hierarchical emulation framework encompassing structured emulators which exploit known constrained and structured behaviour of constituent computer model outputs. This achieves greater physical interpretability and more accurate emulator predictions. This research is motivated by and applied to the commercially important TNO OLYMPUS Well Control Optimisation Challenge from the petroleum industry. We re-express this as a decision support under uncertainty problem. First, we reduce the computational expense of the analysis by identifying a representative subset of models using an efficient multi-model ensemble subsampling technique. Next we apply our hierarchical emulation methodology to the expected Net Present Value utility function with well control decision parameters as inputs., Comment: 41 pages, 14 figures
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- 2024
32. The Road to Freedom: Economics and the Good Society
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Smith, Vernon L.
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Economics ,Political science ,Social sciences - Abstract
* The Road to Freedom: Economics and the Good Society By Joseph E. Stiglitz New York: W. W. Norton, 2024. Pp. 356. $29.99 hardcover. Joseph Stiglitz has written a book [...]
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- 2024
33. Adjuvant Pembrolizumab in Stage II Melanoma: Outcomes by Primary Tumor Location in the Randomized, Double-Blind, Phase III KEYNOTE-716 Trial: KEYNOTE-716 Outcomes by Tumor Location
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Yoon, Charles H., Ross, Merrick I., Gastman, Brian R., Luke, Jason J., Ascierto, Paolo A., Long, Georgina V., Rutkowski, Piotr, Khattak, Muhammad, Del Vecchio, Michele, de la Cruz Merino, Luis, Mackiewicz, Jacek, Chiarion-Sileni, Vanna, Schadendorf, Dirk, Carlino, Matteo S., Zhao, Yujie, Fukunaga-Kalabis, Mizuho, Krepler, Clemens, Eggermont, Alexander M. M., Gershenwald, Jeffrey E., and Sondak, Vernon K.
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- 2025
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34. Scaling and networking a modular photonic quantum computer
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Aghaee Rad, H., Ainsworth, T., Alexander, R. N., Altieri, B., Askarani, M. F., Baby, R., Banchi, L., Baragiola, B. Q., Bourassa, J. E., Chadwick, R. S., Charania, I., Chen, H., Collins, M. J., Contu, P., D’Arcy, N., Dauphinais, G., De Prins, R., Deschenes, D., Di Luch, I., Duque, S., Edke, P., Fayer, S. E., Ferracin, S., Ferretti, H., Gefaell, J., Glancy, S., González-Arciniegas, C., Grainge, T., Han, Z., Hastrup, J., Helt, L. G., Hillmann, T., Hundal, J., Izumi, S., Jaeken, T., Jonas, M., Kocsis, S., Krasnokutska, I., Larsen, M. V., Laskowski, P., Laudenbach, F., Lavoie, J., Li, M., Lomonte, E., Lopetegui, C. E., Luey, B., Lund, A. P., Ma, C., Madsen, L. S., Mahler, D. H., Mantilla Calderón, L., Menotti, M., Miatto, F. M., Morrison, B., Nadkarni, P. J., Nakamura, T., Neuhaus, L., Niu, Z., Noro, R., Papirov, K., Pesah, A., Phillips, D. S., Plick, W. N., Rogalsky, T., Rortais, F., Sabines-Chesterking, J., Safavi-Bayat, S., Sazhaev, E., Seymour, M., Rezaei Shad, K., Silverman, M., Srinivasan, S. A., Stephan, M., Tang, Q. Y., Tasker, J. F., Teo, Y. S., Then, R. B., Tremblay, J. E., Tzitrin, I., Vaidya, V. D., Vasmer, M., Vernon, Z., Villalobos, L. F. S. S. M., Walshe, B. W., Weil, R., Xin, X., Yan, X., Yao, Y., Zamani Abnili, M., and Zhang, Y.
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- 2025
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35. Incidence and Prevalence of Post-COVID-19 Myalgic Encephalomyelitis: A Report from the Observational RECOVER-Adult Study: Post-COVID-19 ME/CFS
- Author
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Vernon, Suzanne D., Zheng, Tianyu, Do, Hyungrok, Marconi, Vincent C., Jason, Leonard A., Singer, Nora G., Natelson, Benjamin H., Sherif, Zaki A., Bonilla, Hector Fabio, Taylor, Emily, Mullington, Janet M., Ashktorab, Hassan, Laiyemo, Adeyinka O., Brim, Hassan, Patterson, Thomas F., Akintonwa, Teresa T., Sekar, Anisha, Peluso, Michael J., Maniar, Nikita, Bateman, Lucinda, Horwitz, Leora I., and Hess, Rachel
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- 2025
- Full Text
- View/download PDF
36. ZIC1 is a context-dependent medulloblastoma driver in the rhombic lip
- Author
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Lee, John J. Y., Tao, Ran, You, Zhen, Haldipur, Parthiv, Erickson, Anders W., Farooq, Hamza, Hendriske, Liam D., Abeysundara, Namal, Richman, Cory M., Wang, Evan Y., Das Gupta, Neha, Hadley, Jennifer, Batts, Melissa, Mount, Christopher W., Wu, Xiaochong, Rasnitsyn, Alex, Bailey, Swneke, Cavalli, Florence M. G., Morrissy, Sorana, Garzia, Livia, Michealraj, Kulandaimanuvel Antony, Visvanathan, Abhi, Fong, Vernon, Palotta, Jonelle, Suarez, Raul, Livingston, Bryn G., Liu, Miao, Luu, Betty, Daniels, Craig, Loukides, James, Bendel, Anne, French, Pim J., Kros, Johan M., Korshunov, Andrey, Kool, Marcel, Chico Ponce de León, Fernando, Perezpeña-Diazconti, Mario, Lach, Boleslaw, Singh, Sheila K., Leary, Sarah E. S., Cho, Byung-Kyu, Kim, Seung-Ki, Wang, Kyu-Chang, Lee, Ji-Yeoun, Tominaga, Teiji, Weiss, William A., Phillips, Joanna J., Dai, Shizhong, Zadeh, Gelareh, Saad, Ali G., Bognár, László, Klekner, Almos, Pollack, Ian F., Hamilton, Ronald L., Ra, Young-shin, Grajkowska, Wieslawa A., Perek-Polnik, Marta, Thompson, Reid C., Kenney, Anna M., Cooper, Michael K., Mack, Stephen C., Jabado, Nada, Lupien, Mathieu, Gallo, Marco, Ramaswamy, Vijay, Suva, Mario L., Suzuki, Hiromichi, Millen, Kathleen J., Huang, L. Frank, Northcott, Paul A., and Taylor, Michael D.
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- 2025
- Full Text
- View/download PDF
37. Annals of Surgical Oncology Practice Guidelines Series: Adjuvant and Neoadjuvant Therapy for Melanoma
- Author
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Farma, Jeffrey M., Olszanski, Anthony J., Messina, Jane L., and Sondak, Vernon K.
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- 2025
- Full Text
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38. Linear system identification of the UC San Diego Geisel Library building under ambient vibration
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Sun, Lin, Conte, Joel P., Todd, Michael D., Astroza, Rodrigo, Bock, Yehuda, Offield, Glen, and Vernon, Frank
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- 2024
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39. New Perspectives for the Deep Learning Based Photography Aesthetics Assessment
- Author
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Asuncion, Vernon, Zhang, Yan, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Gong, Mingming, editor, Song, Yiliao, editor, Koh, Yun Sing, editor, Xiang, Wei, editor, and Wang, Derui, editor
- Published
- 2025
- Full Text
- View/download PDF
40. Data and Analytics in Introductory Managerial Accounting Courses
- Author
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Shan, Yuxin, author and Richardson, Vernon J., author
- Published
- 2024
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41. The electromagnetic symmetry sphere: a framework for energy, momentum, spin and other electromagnetic quantities
- Author
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Golat, Sebastian, Vernon, Alex J., and Rodríguez-Fortuño, Francisco J.
- Subjects
Physics - Optics - Abstract
Electromagnetic quantities such as energy density, momentum, spin, and helicity bring meaning and intuition to electromagnetism and possess intricate interrelations, particularly prominent in complex non-paraxial near-fields. These quantities are conventionally expressed using electric and magnetic field vectors, yet the electric-magnetic basis is one among other often overlooked alternatives, including parallel-antiparallel and right-left-handed helicity bases, related to the parity and duality symmetries of electromagnetism. Projecting time-harmonic electromagnetic fields into a variety of bases allows re-interpreting established quantities and reveals underlying mathematical structures: a Bloch sphere which describes asymmetries in electromagnetic energy, a systematic path to unify and uncover relations between electromagnetic quantities, and the unlocking of symmetry-driven equations in light-matter interaction., Comment: 6 pages, 2 figures, 3 tables
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- 2024
42. System and Method to Determine ME/CFS and Long COVID Disease Severity Using a Wearable Sensor
- Author
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Sun, Yifei, Vernon, Suzanne D., and Roundy, Shad
- Subjects
Quantitative Biology - Quantitative Methods ,Computer Science - Computers and Society ,Statistics - Applications - Abstract
Objective: We present a simple parameter, calculated from a single wearable sensor, that can be used to objectively measure disease severity in people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) or Long COVID. We call this parameter UpTime. Methods: Prior research has shown that the amount of time a person spends upright, defined as lower legs vertical with feet on the floor, correlates strongly with ME/CFS disease severity. We use a single commercial inertial measurement unit (IMU) attached to the ankle to calculate the percentage of time each day that a person spends upright (i.e., UpTime) and number of Steps/Day. As Long COVID shares symptoms with ME/CFS, we also apply this method to determine Long COVID disease severity. We performed a trial with 55 subjects broken into three cohorts, healthy controls, ME/CFS, and Long COVID. Subjects wore the IMU on their ankle for a period of 7 days. UpTime and Steps/Day were calculated each day and results compared between cohorts. Results: UpTime effectively distinguishes between healthy controls and subjects diagnosed with ME/CFS ($\mathbf{p = 0.00004}$) and between healthy controls and subjects diagnosed with Long COVID ($\mathbf{p = 0.01185}$). Steps/Day did distinguish between controls and subjects with ME/CFS ($\mathbf{p = 0.01}$) but did not distinguish between controls and subjects with Long COVID ($\mathbf{p = 0.3}$). Conclusion: UpTime is an objective measure of ME/CFS and Long COVID severity. UpTime can be used as an objective outcome measure in clinical research and treatment trials. Significance: Objective assessment of ME/CFS and Long COVID disease severity using UpTime could spur development of treatments by enabling the effect of those treatments to be easily measured.
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- 2024
43. Stau pairs from natural SUSY at high luminosity LHC
- Author
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Baer, Howard, Barger, Vernon, and Zhang, Kairui
- Subjects
High Energy Physics - Phenomenology - Abstract
Natural supersymmetry (SUSY) with light higgsinos is perhaps the most plausible of all weak scale SUSY models while a variety of motivations point to (right) tau sleptons as the lightest of all the sleptons. We examine a SUSY model line with rather light right-staus embedded within natural SUSY. For light stau_1 of a few hundred GeV, then the decays stau_1 -> \tau\tchi_{1,2}^0 and \nu_\tau\tchi_1^- occur at comparable rates where the (higgsino-like) \tchi_1^\pm and \tchi_2^0 release only small visible energy: in this case, the expected \tau^+\tau^- +\eslt signature is diminished from usual expectations due to the presence of the nearly invisible decay mode \ttau_1 -> \nu_\tau\tchi_1^-. However, once m_{\ttau_1}> ~m(bino), then decays to binos such as \ttau_1 -> \tau\tchi_3^0 open up where \tchi_3^0 decays to higgsinos plus W^\pm, Z^0 and h at comparable rates. For these heavier staus, then stau pair production gives rise to diboson+\eslt events which may contain 0, 1 or 2 additional hard \tau leptons. From these considerations, we examine the potential for future discovery of tau-slepton pair production at high-luminosity LHC. While we do not find a 5\sigma HL-LHC discovery reach for 3000 fb^{-1}, we do find a 95\% CL exclusion reach, ranging between m_{\ttau_1}:100-450 GeV for m_{\tchi_1^0}~ 100 GeV. This latter reach disappears for m_{\tchi_1^0}>~ 200 GeV., Comment: 20 pages including 7 .png figures; version 2 should coincide with published version and fixes several typos
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- 2024
44. PuzzleVQA: Diagnosing Multimodal Reasoning Challenges of Language Models with Abstract Visual Patterns
- Author
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Chia, Yew Ken, Han, Vernon Toh Yan, Ghosal, Deepanway, Bing, Lidong, and Poria, Soujanya
- Subjects
Computer Science - Computer Vision and Pattern Recognition - Abstract
Large multimodal models extend the impressive capabilities of large language models by integrating multimodal understanding abilities. However, it is not clear how they can emulate the general intelligence and reasoning ability of humans. As recognizing patterns and abstracting concepts are key to general intelligence, we introduce PuzzleVQA, a collection of 2000 puzzle instances based on abstract patterns. With this dataset, we evaluate large multimodal models with abstract patterns based on fundamental concepts, including colors, numbers, sizes, and shapes. Through our experiments on state-of-the-art large multimodal models, we find that they are not able to generalize well to simple abstract patterns. Notably, GPT-4V achieves a score of 46.4% on single-concept puzzles, which shows that state-of-the-art models struggle on our dataset. To diagnose the reasoning challenges in large multimodal models, we progressively guide the models with our ground truth reasoning explanations for visual perception, inductive reasoning, and deductive reasoning. Our systematic analysis finds that the main bottlenecks of GPT-4V are weaker visual perception and inductive reasoning abilities. Through this work, we hope to shed light on the limitations of large multimodal models and how they can better emulate human cognitive processes in the future. Our data and code are available at https://puzzlevqa.github.io, Comment: ACL 2024 Camera Ready
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- 2024
45. Are Language Models Puzzle Prodigies? Algorithmic Puzzles Unveil Serious Challenges in Multimodal Reasoning
- Author
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Ghosal, Deepanway, Han, Vernon Toh Yan, Ken, Chia Yew, and Poria, Soujanya
- Subjects
Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Artificial Intelligence - Abstract
This paper introduces the novel task of multimodal puzzle solving, framed within the context of visual question-answering. We present a new dataset, AlgoPuzzleVQA designed to challenge and evaluate the capabilities of multimodal language models in solving algorithmic puzzles that necessitate both visual understanding, language understanding, and complex algorithmic reasoning. We create the puzzles to encompass a diverse array of mathematical and algorithmic topics such as boolean logic, combinatorics, graph theory, optimization, search, etc., aiming to evaluate the gap between visual data interpretation and algorithmic problem-solving skills. The dataset is generated automatically from code authored by humans. All our puzzles have exact solutions that can be found from the algorithm without tedious human calculations. It ensures that our dataset can be scaled up arbitrarily in terms of reasoning complexity and dataset size. Our investigation reveals that large language models (LLMs) such as GPT4V and Gemini exhibit limited performance in puzzle-solving tasks. We find that their performance is near random in a multi-choice question-answering setup for a significant number of puzzles. The findings emphasize the challenges of integrating visual, language, and algorithmic knowledge for solving complex reasoning problems.
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- 2024
46. Does light slowdown in dielectric media?
- Author
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Cooray, Vernon, Cooray, Gerald, Rachidi, Farhad, and Rubinstein, Marcos
- Subjects
Physics - Optics ,Physics - Classical Physics - Abstract
Observations and theoretical principles suggest that electromagnetic waves, including light, travel more slowly in dielectric media than in vacuum. Maxwell's equations, incorporating material dependent permittivity and permeability, elegantly capture this effect. Previous studies indicate that the observed slower speed is due to interference effects, with the actual electromagnetic fields in the dielectric propagating at the speed of light in vacuum. However, these studies did not provide explicit expressions for the field components moving at this speed. The aim of the present study is to address this gap by analysing the structure of the electromagnetic field components within the dielectric. We examine how these components, each traveling at the speed of light in vacuum, interact to produce a net field that appears to propagate more slowly. Our findings show that the observed slower propagation in dielectric media results from interference between two types of waves: a forward moving incident wave and a set of secondary waves, moving both in the forward and backward directions, and induced by the interaction of the incident wave with the dielectric medium. Both the incident wave and the secondary waves travel at the speed of light in vacuum. Importantly, we observe that the reflected wave caused by the impedance discontinuity at the boundary of the dielectric medium arises from secondary waves moving in the direction opposite to the incident wave., Comment: 12 pages, 4 figures
- Published
- 2024
47. Early rhombic lip Protogenin+ve stem cells in a human-specific neurovascular niche initiate and maintain group 3 medulloblastoma.
- Author
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Visvanathan, Abhirami, Saulnier, Olivier, Chen, Chuan, Haldipur, Parthiv, Orisme, Wilda, Delaidelli, Alberto, Shin, Seungmin, Millman, Jake, Bryant, Andrew, Abeysundara, Namal, Wu, Xujia, Hendrikse, Liam, Patil, Vikas, Bashardanesh, Zahedeh, Golser, Joseph, Livingston, Bryn, Nakashima, Takuma, Funakoshi, Yusuke, Ong, Winnie, Rasnitsyn, Alexandra, Aldinger, Kimberly, Richman, Cory, Van Ommeren, Randy, Lee, John, Ly, Michelle, Vladoiu, Maria, Kharas, Kaitlin, Balin, Polina, Erickson, Anders, Fong, Vernon, Zhang, Jiao, Suárez, Raúl, Wang, Hao, Huang, Ning, Pallota, Jonelle, Douglas, Tajana, Haapasalo, Joonas, Razavi, Ferechte, Silvestri, Evelina, Sirbu, Olga, Worme, Samantha, Kameda-Smith, Michelle, Wu, Xiaochong, Daniels, Craig, MichaelRaj, Antony, Bhaduri, Aparna, Schramek, Daniel, Suzuki, Hiromichi, Garzia, Livia, Ahmed, Nabil, Kleinman, Claudia, Stein, Lincoln, Dirks, Peter, Dunham, Christopher, Jabado, Nada, Rich, Jeremy, Li, Wei, Sorensen, Poul, Wechsler-Reya, Robert, Weiss, William, Millen, Kathleen, Ellison, David, Dimitrov, Dimiter, and Taylor, Michael
- Subjects
brain development ,brain tumor immunotherapy ,cancer genomics ,group 3 medulloblastoma ,perivascular niche ,rhombic lip ,Humans ,Medulloblastoma ,Animals ,Neoplastic Stem Cells ,Mice ,Rhombencephalon ,Cerebellar Neoplasms ,Endothelial Cells ,Stem Cell Niche ,Stem Cells ,Coculture Techniques ,Embryonic Structures ,Metencephalon - Abstract
We identify a population of Protogenin-positive (PRTG+ve) MYChigh NESTINlow stem cells in the four-week-old human embryonic hindbrain that subsequently localizes to the ventricular zone of the rhombic lip (RLVZ). Oncogenic transformation of early Prtg+ve rhombic lip stem cells initiates group 3 medulloblastoma (Gr3-MB)-like tumors. PRTG+ve stem cells grow adjacent to a human-specific interposed vascular plexus in the RLVZ, a phenotype that is recapitulated in Gr3-MB but not in other types of medulloblastoma. Co-culture of Gr3-MB with endothelial cells promotes tumor stem cell growth, with the endothelial cells adopting an immature phenotype. Targeting the PRTGhigh compartment of Gr3-MB in vivo using either the diphtheria toxin system or chimeric antigen receptor T cells constitutes effective therapy. Human Gr3-MBs likely arise from early embryonic RLVZ PRTG+ve stem cells inhabiting a specific perivascular niche. Targeting the PRTGhigh compartment and/or the perivascular niche represents an approach to treat children with Gr3-MB.
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- 2024
48. The San Francisco Health Systems Collaborative: Public Health and Health Care Delivery Systems Response to the Covid-19 Pandemic.
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Mercer, Mary, Day, Lukejohn, Ansari, Maria, Kwan, Elizabeth, Kotis, Desi, Caplan, Valerie, Nguyen, Trang, Lee, Christopher, Smith, Matthew, Tenner, Andrea, Sangha, Baljeet, Rivera, Tiffany, Saelee, Kenpou, Horton, Claire, Green, Adrienne, Giang, Vernon, Ovbiagele, Bruce, Quock, Justin, LeVine, Todd, Sears, Jonathan, Chow, Amabel, Schafer, Ellie, Morse, Eleanor, Brown, John, Connelly, Elizabeth, Marks, Jim, Enanoria, Wayne, Ehrlich, Susan, Philip, Susan, Bobba, Naveena, and Colfax, Grant
- Abstract
The Covid-19 pandemic challenged health care delivery systems worldwide. Many acute care hospitals in communities that experienced surges in cases and hospitalizations had to make decisions such as rationing scarce resources. Hospitals serving low-income communities, communities of color, and those in other historically marginalized or vulnerable groups reported the greatest operational impacts of surges. However, cross-institutional collaborations within jurisdictions offer unique opportunities to prevent or mitigate health disparities in resource utilization and access to care. In January 2020, in response to the emerging coronavirus epidemic, the San Francisco Department of Public Health (SFDPH) and local hospital and health systems partners convened to align and coordinate medical surge planning and response. Adopting a governance structure of mutual accountability and transparency, the San Francisco Health Systems Collaborative guided local medical and public health response in the areas of medical surge, vaccination administration, testing, and therapeutics. Four principles guided the collaborative response: (1) shared priorities, (2) clear governance and accountability, (3) data transparency, and (4) operational coordination. High-level priorities established included protecting vulnerable people, protecting health care workers, and maintaining health system capacity. The governance structure consisted of three layers: local hospital and health systems CEOs coordinating with SFDPH executives; hospital chief medical and nursing officers coordinating high-level surge capacity assessments and mitigation plans; and local clinical operational managers working with public health response operational leaders to coordinate scarce resource utilization. Fluctuating with the tempo of the disease indicators and medical surge, governance and coordination were maintained through a tiered meeting and reporting system. Data visibility and transparency were key principles facilitating operational decision-making and executive-level coordination of resources, including identifying additional surge bed capacity for use systemwide, as well as ensuring efficient and equitable vaccine distribution through implementation of five mass-vaccination sites with prioritized access for vulnerable communities. Applying these four principles of shared priorities, accountability, transparency, and operational coordination and pragmatism helped the public health and individual hospital systems make contributions to the overall response that were aligned with their unique strengths and resources. Publication here represents the first official public use of the name San Francisco Health Systems Collaborative (which had served as the term used internally to refer to the group) and the first time codifying this structure. Through this coordination, San Francisco achieved one of the lowest Covid-19 death rates and had one of the highest vaccination and booster rates, compared with rates across California or the United States. Similar principles and implementation methods can be adopted by other health jurisdictions for future emergency outbreak response.
- Published
- 2024
49. AMPED study: Protocol for a randomized controlled trial of different doses of aerobic exercise training.
- Author
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Stine, Jonathan, Hummer, Breianna, Smith, Nataliya, Tressler, Heather, Heinle, J, VanKirk, Kyra, Harris, Sara, Moeller, Matthew, Luzier, Gavin, DiJoseph, Kara, Hussaini, Zeba, Jackson, Ryan, Rodgers, Brandon, Schreibman, Ian, Stonesifer, Elizabeth, Tondt, Justin, Sica, Chris, Nighot, Prashant, Chinchilli, Vernon, Loomba, Rohit, Sciamanna, Christopher, Schmitz, Kathryn, and Kimball, Scot
- Subjects
Humans ,Middle Aged ,Adult ,Aged ,Exercise ,Adolescent ,Male ,Female ,Young Adult ,Exercise Therapy ,Liver ,Magnetic Resonance Imaging ,Non-alcoholic Fatty Liver Disease ,Biomarkers ,Quality of Life - Abstract
Recently renamed, metabolic dysfunction-associated steatotic liver disease remains a leading cause of chronic liver disease worldwide. Regular physical activity is recommended as a treatment for all with this condition because it is highly efficacious, especially when exercise training is undertaken with a specific goal in mind. Despite decades of research demonstrating exercises efficacy, key questions remain about the mechanism of benefit and most efficacious dose, as well as the independent impact on liver histology. To answer these questions, we present the design of a 16-week randomized controlled clinical trial of 45 adults aged 18-69 years with metabolic dysfunction-associated steatohepatitis. The primary aim of this study is to better understand the dose required and mechanisms to explain how exercise impacts multiple clinical end points in metabolic dysfunction-associated steatohepatitis. The primary outcome is MRI-measured liver fat. Secondary outcomes include other biomarkers of liver fibroinflammation, liver histology, and mechanistic pathways, as well as cardiometabolic risk and quality of life. This is the first study to compare different doses of exercise training to determine if there is a differential impact on imaging and serum biomarkers as well as liver histology.
- Published
- 2024
50. Allele-specific dysregulation of lipid and energy metabolism in early-stage hypertrophic cardiomyopathy
- Author
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Vaniya, Arpana, Karlstaedt, Anja, Gulkok, Damla, Thottakara, Tilo, Liu, Yamin, Fan, Sili, Eades, Hannah, Vakrou, Styliani, Fukunaga, Ryuya, Vernon, Hilary J, Fiehn, Oliver, and Abraham, M Roselle
- Subjects
Medical Biochemistry and Metabolomics ,Biological Sciences ,Biomedical and Clinical Sciences ,Genetics ,Pediatric ,Cardiovascular ,Nutrition ,Pediatric Cardiomyopathy ,Heart Disease ,Rare Diseases ,2.1 Biological and endogenous factors ,Untargeted metabolomics ,Lipidomics ,Hypertrophic cardiomyopathy ,RNAseq ,HCM mouse models - Abstract
IntroductionHypertrophic cardiomyopathy (HCM) results from pathogenic variants in sarcomeric protein genes that increase myocyte energy demand and lead to cardiac hypertrophy. However, it is unknown whether a common metabolic trait underlies cardiac phenotype at the early disease stage. To address this question and define cardiac biochemical pathology in early-stage HCM, we studied two HCM mouse models that express pathogenic variants in cardiac troponin T (Tnt2) or myosin heavy chain (Myh6) genes, and have marked differences in cardiac imaging phenotype, mitochondrial function at early disease stage.MethodsWe used a combination of echocardiography, transcriptomics, mass spectrometry-based untargeted metabolomics (GC-TOF, HILIC, CSH-QTOF), and computational modeling (CardioNet) to examine cardiac structural and metabolic remodeling at early disease stage (5 weeks of age) in R92W-TnT+/- and R403Q-MyHC+/- mutant mice. Data from mutants was compared with respective littermate controls (WT).ResultsAllele-specific differences in cardiac phenotype, gene expression and metabolites were observed at early disease stage. LV diastolic dysfunction was prominent in TnT mutants. Differentially-expressed genes in TnT mutant hearts were predominantly enriched in the Krebs cycle, respiratory electron transport, and branched-chain amino acid metabolism, whereas MyHC mutants were enriched in mitochondrial biogenesis, calcium homeostasis, and liver-X-receptor signaling. Both mutant hearts demonstrated significant alterations in levels of purine nucleosides, trisaccharides, dicarboxylic acids, acylcarnitines, phosphatidylethanolamines, phosphatidylinositols, ceramides and triglycerides; 40.4 % of lipids and 24.7 % of metabolites were significantly different in TnT mutants, whereas 10.4 % of lipids and 5.8 % of metabolites were significantly different in MyHC mutants. Both mutant hearts had a lower abundance of unsaturated long-chain acyl-carnitines (18:1, 18:2, 20:1), but only TnT mutants showed enrichment of FA18:0 in ceramide and cardiolipin species. CardioNet predicted impaired energy substrate metabolism and greater phospholipid remodeling in TnT mutants than in MyHC mutants.ConclusionsOur systems biology approach revealed marked differences in metabolic remodeling in R92W-TnT and R403Q-MyHC mutant hearts, with TnT mutants showing greater derangements than MyHC mutants, at early disease stage. Changes in cardiolipin composition in TnT mutants could contribute to impairment of energy metabolism and diastolic dysfunction observed in this study, and predispose to energetic stress, ventricular arrhythmias under high workloads such as exercise.
- Published
- 2024
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