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1. Zika vector competence data reveals risks of outbreaks: the contribution of the European ZIKAlliance project

Author

Thomas Obadia, Gladys Gutierrez-Bugallo, Veasna Duong, Ana I. Nuñez, Rosilainy S. Fernandes, Basile Kamgang, Liza Hery, Yann Gomard, Sandra R. Abbo, Davy Jiolle, Uros Glavinic, Myrielle Dupont-Rouzeyrol, Célestine M. Atyame, Nicolas Pocquet, Sébastien Boyer, Catherine Dauga, Marie Vazeille, André Yébakima, Michael T. White, Constantianus J. M. Koenraadt, Patrick Mavingui, Anubis Vega-Rua, Eva Veronesi, Gorben P. Pijlman, Christophe Paupy, Núria Busquets, Ricardo Lourenço-de-Oliveira, Xavier De Lamballerie, and Anna-Bella Failloux

Subjects
Science
Abstract

Zika virus (ZIKV), the causative agent of virus-induced brain damage in newborns, is transmitted by mosquitoes, mainly Aedes aegypti, and secondarily, Aedes albopictus. Here, Obadia et al. characterize ZIKV vector competence of 50 mosquito populations from six species collected in 12 different countries to inform about epidemic risk. They find that African ZIKV strain shows higher transmission efficiency compared to American and Asian ZIKV strains and that Ae. aegypti mosquitoes have highest susceptibility to infections, while Culexmosquitoes are largely non-susceptible.

Published
2022
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3. GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 5: Entomological aspects

Author

Brasil, P., Busch, M., Diamond, M.S., Drebot, M.A., Gallian, P., Jaenisch, T., LaBeaud, A.D., Lecuit, M., Neyts, J., Reusken, C.B., Ribeiro, G.S., Rios, M., Rodriguez-Morales, A.J., Sall, A., Simmons, G., Simon, F., Siqueira, A.M., Pezzi, L., Diallo, M., Rosa-Freitas, M.G., Vega-Rua, A., Ng, L.F.P., Boyer, S., Drexler, J.F., Vasilakis, N., Lourenco-de-Oliveira, R., Weaver, S.C., Kohl, A., de Lamballerie, X., and Failloux, A.-B.

Published
2020
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5. GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 2: Epidemiological distribution of o'nyong-nyong virus

Author

Boyer, S., Brasil, P., Busch, M., Diamond, M.S., Drebot, M.A., Kohl, A., Lecuit, M., Lourenço-de-Oliveira, R., Neyts, J., Lfp, Ng, Ribeiro, G.S., Rios, M., Rodriguez-Morales, A.J., Rosa-Freitas, M.G., Simmons, G., Siqueira, A.M., Vega Rua, A., Pezzi, L., LaBeaud, A.D., Reusken, C.B., Drexler, J.F., Vasilakis, N., Diallo, M., Simon, F., Jaenisch, T., Gallian, P., Sall, A., Failloux, A.B., Weaver, S.C., and de Lamballerie, X.

Published
2019
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6. GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 3: Epidemiological distribution of Mayaro virus

Author

Boyer, S., Busch, M., Diallo, M., Diamond, M.S., Drebot, M.A., Kohl, A., Neyts, J., Ng, L.F.P., Rios, M., Sall, A., Simmons, G., Pezzi, L., Rodriguez-Morales, A.J., Reusken, C.B., Ribeiro, G.S., LaBeaud, A.D., Lourenço-de-Oliveira, R., Brasil, P., Lecuit, M., Failloux, A.B., Gallian, P., Jaenisch, T., Simon, F., Siqueira, A.M., Rosa-Freitas, M.G., Vega Rua, A., Weaver, S.C., Drexler, J.F., Vasilakis, N., and de Lamballerie X

Published
2019
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7. GloPID-R report on Chikungunya, O'nyong-nyong and Mayaro virus, part I: Biological diagnostics

Author

Boyer, S., Brasil, P., Diallo, M., Failloux, A.B., Jaenisch, T., Lourenço-de-Oliveira, R., Neyts, J., Rios, M., Rodriguez-Morales, A.J., Rosa-Freitas, M.G., Sall, A., Simmons, G., Simon, F., Vega Rua, A., Pezzi, L., Reusken, C.B., Weaver, S.C., Drexler, J.F., Busch, M., LaBeaud, A.D., Diamond, M.S., Vasilakis, N., Drebot, M.A., Siqueira, A.M., Ribeiro, G.S., Kohl, A., Lecuit, M., Ng, L.F.P., Gallian, P., and de Lamballerie, X.

Published
2019
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9. First Report of Natural Wolbachia Infections in Mosquitoes from Cuba

Author

Ruiz Esquivel, Armando Miguel, primary, Gutierrez-Bugallo, Gladys, additional, Rodriguez-Roche, Rosmari, additional, Perez, Lissette, additional, Gonzales-Broche, Raul, additional, Piedra, Luis, additional, Martinez, Liss Claudia, additional, Menendez, Zulema, additional, Vega-Rua, Anubis, additional, and Bisset, Juan Andres, additional

Published
2023
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12. Zika vector competence data reveals risks of outbreaks: the contribution of the European ZIKAlliance project

Author

Obadia, Thomas, primary, Gutierrez-Bugallo, Gladys, additional, Duong, Veasna, additional, Nuñez, Ana I., additional, Fernandes, Rosilainy S., additional, Kamgang, Basile, additional, Hery, Liza, additional, Gomard, Yann, additional, Abbo, Sandra R., additional, Jiolle, Davy, additional, Glavinic, Uros, additional, Dupont-Rouzeyrol, Myrielle, additional, Atyame, Célestine M., additional, Pocquet, Nicolas, additional, Boyer, Sébastien, additional, Dauga, Catherine, additional, Vazeille, Marie, additional, Yébakima, André, additional, White, Michael T., additional, Koenraadt, Constantianus J. M., additional, Mavingui, Patrick, additional, Vega-Rua, Anubis, additional, Veronesi, Eva, additional, Pijlman, Gorben P., additional, Paupy, Christophe, additional, Busquets, Núria, additional, Lourenço-de-Oliveira, Ricardo, additional, De Lamballerie, Xavier, additional, and Failloux, Anna-Bella, additional

Published
2022
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13. Differential Susceptibilities of Aedes aegypti and Aedes albopictus from the Americas to Zika Virus.

Author

Thais Chouin-Carneiro, Anubis Vega-Rua, Marie Vazeille, André Yebakima, Romain Girod, Daniella Goindin, Myrielle Dupont-Rouzeyrol, Ricardo Lourenço-de-Oliveira, and Anna-Bella Failloux

Subjects
Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270
Abstract

BACKGROUND:Since the major outbreak in 2007 in the Yap Island, Zika virus (ZIKV) causing dengue-like syndromes has affected multiple islands of the South Pacific region. In May 2015, the virus was detected in Brazil and then spread through South and Central America. In December 2015, ZIKV was detected in French Guiana and Martinique. The aim of the study was to evaluate the vector competence of the mosquito spp. Aedes aegypti and Aedes albopictus from the Caribbean (Martinique, Guadeloupe), North America (southern United States), South America (Brazil, French Guiana) for the currently circulating Asian genotype of ZIKV isolated from a patient in April 2014 in New Caledonia. METHODOLOGY/PRINCIPAL FINDINGS:Mosquitoes were orally exposed to an Asian genotype of ZIKV (NC-2014-5132). Upon exposure, engorged mosquitoes were maintained at 28° ± 1 °C, a 16h:8h light:dark cycle and 80% humidity. 25-30 mosquitoes were processed at 4, 7 and 14 days post-infection (dpi). Mosquito bodies (thorax and abdomen), heads and saliva were analyzed to measure infection, dissemination and transmission, respectively. High infection but lower disseminated infection and transmission rates were observed for both Ae. aegypti and Ae. albopictus. Ae. aegypti populations from Guadeloupe and French Guiana exhibited a higher dissemination of ZIKV than the other Ae. aegypti populations examined. Transmission of ZIKV was observed in both mosquito species at 14 dpi but at a low level. CONCLUSIONS/SIGNIFICANCE:This study suggests that although susceptible to infection, Ae. aegypti and Ae. albopictus were unexpectedly low competent vectors for ZIKV. This may suggest that other factors such as the large naïve population for ZIKV and the high densities of human-biting mosquitoes contribute to the rapid spread of ZIKV during the current outbreak.

Published
2016
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14. Zika vector competence data reveals risks of outbreaks: the contribution of the European ZIKAlliance project

Author

Obadia, Thomas, Gutierrez-Bugallo, Gladys, Duong, Veasna, Nuñez, Ana I., Fernandes, Rosilainy S., Kamgang, Basile, Hery, Liza, Gomard, Yann, Abbo, Sandra R., Jiolle, Davy, Glavinić, Uroš, Dupont-Rouzeyrol, Myrielle, Atyame, Célestine M., Pocquet, Nicolas, Boyer, Sébastien, Dauga, Catherine, Vazeille, Marie, Yébakima, André, White, Michael T., Koenraadt, Constantianus J. M., Mavingui, Patrick, Vega-Rua, Anubis, Veronesi, Eva, Pijlman, Gorben P., Paupy, Christophe, Busquets, Núria, Lourenço-de-Oliveira, Ricardo, De Lamballerie, Xavier, Failloux, Anna-Bella, Obadia, Thomas, Gutierrez-Bugallo, Gladys, Duong, Veasna, Nuñez, Ana I., Fernandes, Rosilainy S., Kamgang, Basile, Hery, Liza, Gomard, Yann, Abbo, Sandra R., Jiolle, Davy, Glavinić, Uroš, Dupont-Rouzeyrol, Myrielle, Atyame, Célestine M., Pocquet, Nicolas, Boyer, Sébastien, Dauga, Catherine, Vazeille, Marie, Yébakima, André, White, Michael T., Koenraadt, Constantianus J. M., Mavingui, Patrick, Vega-Rua, Anubis, Veronesi, Eva, Pijlman, Gorben P., Paupy, Christophe, Busquets, Núria, Lourenço-de-Oliveira, Ricardo, De Lamballerie, Xavier, and Failloux, Anna-Bella

Abstract

First identified in 1947, Zika virus took roughly 70 years to cause a pandemic unusually associated with virus-induced brain damage in newborns. Zika virus is transmitted by mosquitoes, mainly Aedes aegypti, and secondarily, Aedes albopictus, both colonizing a large strip encompassing tropical and temperate regions. As part of the international project ZIKAlliance initiated in 2016, 50 mosquito populations from six species collected in 12 countries were experimentally infected with different Zika viruses. Here, we show that Ae. aegypti is mainly responsible for Zika virus transmission having the highest susceptibility to viral infections. Other species play a secondary role in transmission while Culex mosquitoes are largely non-susceptible. Zika strain is expected to significantly modulate transmission efficiency with African strains being more likely to cause an outbreak. As the distribution of Ae. aegypti will doubtless expand with climate change and without new marketed vaccines, all the ingredients are in place to relive a new pandemic of Zika.

Published
2022

15. Chemoecological Study of Trophic Interaction Between Pseudosphinx Tetrio L. Larvae and Allamanda Cathartica L.

Author

MATIGNON, LINDA, primary, LO, MAME E MARIETOU, additional, VICENTINI, MAURO, additional, VALENCIA, DROCHS PETRI, additional, PALMEIRA-MELLO, MARCOS V., additional, SYLVESTRE, MURIEL, additional, PASSE-COUTRIN, NADY, additional, VEGA-RUA, ANUBIS, additional, Domenech, Antonio, additional, BENFODDA, ZOHRA, additional, Meffre, Patrick, additional, and Cebrián-Torrejón, Gerardo, additional

Published
2021
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17. High efficiency of temperate Aedes albopictus to transmit chikungunya and dengue viruses in the Southeast of France.

Author

Anubis Vega-Rua, Karima Zouache, Valerie Caro, Laure Diancourt, Pascal Delaunay, Marc Grandadam, and Anna-Bella Failloux

Subjects
Medicine, Science
Abstract

BACKGROUND: Since 2005, cases of chikungunya (CHIK) were caused by an unusual vector, Aedes albopictus. This mosquito, present in Europe since 1979, has gained importance since its involvement in the first CHIK outbreak in Italy in 2007. The species is capable of transmitting experimentally 26 arboviruses. However, the vectorial status of its temperate populations has remained little investigated. In 2010, autochthonous cases of CHIK and dengue (DEN) were reported in southeastern France. We evaluated the potential of a French population of Ae. albopictus in the transmission of both viruses. METHODOLOGY AND PRINCIPAL FINDINGS: We used two strains of each virus, CHIK AND DEN: one strain was isolated from an imported case, and one from an autochthonous case. We used as controls Aedes aegypti from India and Martinique, the source of the imported cases of CHIK and DEN, respectively. We showed that Ae. albopictus from Cagnes-sur-Mer (AL-CSM) was as efficient as the typical tropical vector Ae. aegypti from India to experimentally transmit both CHIK strains isolated from patients in Fréjus, with around 35-67% of mosquitoes delivering up to 14 viral particles at day 3 post-infection (pi). The unexpected finding came from the high efficiency of AL-CSM to transmit both strains of DENV-1 isolated from patients in Nice. Almost 67% of Ae. albopictus AL-CSM which have ensured viral dissemination were able to transmit at day 9 pi when less than 21% of the typical DEN vector Ae. aegypti from Martinique could achieve transmission. CONCLUSIONS/SIGNIFICANCE: Temperate Ae. albopictus behaves differently compared to its counterpart from tropical regions, where recurrent epidemic outbreaks occur. Its potential responsibility for outbreaks in Europe should not be minimized.

Published
2013
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19. Natural Variation in Physicochemical Profiles and Bacterial Communities Associated withAedes aegyptiBreeding Sites and Larvae on Guadeloupe and French Guiana

Author

Hery, Lyza, Guidez, Amandine, Durand, Audrey-anne, Delannay, Christelle, Normandeux-guimond, Josiann, Reynaud, Yann, Issaly, Jean, Goindin, Daniella, Legrave, Gregory, Gustave, Joel, Raffestin, Stephanie, Breurec, Sebastien, Constant, Philippe, Dusfour, Isabelle, Guertin, Claude, Vega-rua, Anubis, Hery, Lyza, Guidez, Amandine, Durand, Audrey-anne, Delannay, Christelle, Normandeux-guimond, Josiann, Reynaud, Yann, Issaly, Jean, Goindin, Daniella, Legrave, Gregory, Gustave, Joel, Raffestin, Stephanie, Breurec, Sebastien, Constant, Philippe, Dusfour, Isabelle, Guertin, Claude, and Vega-rua, Anubis

Abstract

Aedes aegyptidevelop in aquatic habitats in which mosquito larvae are exposed to physicochemical elements and microorganisms that may influence their life cycle and their ability to transmit arboviruses. Little is known about the natural bacterial communities associated withA. aegyptior their relation to the biotic and abiotic characteristics of their aquatic habitats. We characterized the physicochemical properties and bacterial microbiota ofA. aegyptibreeding sites and larvae on Guadeloupe and in French Guiana. In addition, we explored whether geographic location, the type of breeding site and physicochemical parameters influenced the microbiota associated with this mosquito species. We used large-scale 16S rRNA gene sequencing of 160 breeding sites and 147 pools ofA. aegyptilarvae and recorded 12 physicochemical parameters at the sampled breeding sites. Ordination plots and multiple linear regression were used to assess the influence of environmental factors on the bacterial microbiota of water and larvae. We found territory-specific differences in physicochemical properties (dissolved oxygen, conductivity) and the composition of bacterial communities inA. aegyptibreeding sites that influenced the relative abundance of several bacteria genera (e.g.,Methylobacterium,Roseoccocus) on the corresponding larvae. A significant fraction of the bacterial communities identified on larvae, dominated byHerbiconiuxandMicrovirgagenera, were consistently enriched in mosquitoes regardless the location. In conclusion, territory-specific differences observed in the biotic and abiotic properties ofA. aegyptibreeding sites raise concern about the impact of these changes on pathogen transmission by differentA. aegyptipopulations.

Published
2021
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20. GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 5: Entomological aspects

Author

Pezzi, L., primary, Diallo, M., additional, Rosa-Freitas, M.G., additional, Vega-Rua, A., additional, Ng, L.F.P., additional, Boyer, S., additional, Drexler, J.F., additional, Vasilakis, N., additional, Lourenco-de-Oliveira, R., additional, Weaver, S.C., additional, Kohl, A., additional, de Lamballerie, X., additional, Failloux, A.-B., additional, Brasil, P., additional, Busch, M., additional, Diamond, M.S., additional, Drebot, M.A., additional, Gallian, P., additional, Jaenisch, T., additional, LaBeaud, A.D., additional, Lecuit, M., additional, Neyts, J., additional, Reusken, C.B., additional, Ribeiro, G.S., additional, Rios, M., additional, Rodriguez-Morales, A.J., additional, Sall, A., additional, Simmons, G., additional, Simon, F., additional, and Siqueira, A.M., additional

Published
2020
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21. Experimental assesment of Zika virus mechanical transmission by Aedes aegypti

Author

A., Boullis, Cordel, N, Cecile, Herrmann-Strock, Vega Rua, Anubis, Service de Dermatologie et Médecine Interne, CHU Pointe-à-Pitre/Abymes [Guadeloupe], and Gros, Olivier

Subjects
[SDE.BE] Environmental Sciences/Biodiversity and Ecology, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2019

22. Intrinsic ability of cuban Aedes aedypti populations to transmit Dengue, Chikungunya and Zika viruses

Author

Gutierrez, G., Boullis, Antoine, Martínez, Y., Hery, Lyza, Rodriguez, M.M., Bisset, J.A., Vega Rua, Anubis, Instituto de Medicina Tropical «Pedro Kouri» Cuba, Institut Pasteur de la Guadeloupe, Réseau International des Instituts Pasteur (RIIP), and Gros, Olivier

Subjects
[SDE.BE] Environmental Sciences/Biodiversity and Ecology, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2019

23. GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 2: Epidemiological distribution of o'nyong-nyong virus

Author

M. G. Rosa-Freitas, Sébastien Boyer, A. J. Rodriguez-Morales, Jan Felix Drexler, Thomas Jaenisch, Patrícia Brasil, Johan Neyts, François Simon, Anna-Bella Failloux, de Lamballerie X, Lisa F. P. Ng, Michael A. Drebot, Pierre Gallian, Guilherme S. Ribeiro, Maria Rios, Amadou A. Sall, Chantal Reusken, Marc Lecuit, Scott C. Weaver, Michael P. Busch, Nikos Vasilakis, André Siqueira, A. Vega Rua, Angelle Desiree LaBeaud, Mawlouth Diallo, Michael S. Diamond, Alain Kohl, Ricardo Lourenço-de-Oliveira, Laura Pezzi, Graham Simmons, Unité des Virus Emergents (UVE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Virologie [UNIV Corse-Inserm] (EA7310), Université Pascal Paoli (UPP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Stanford School of Medicine [Stanford], Stanford Medicine, Stanford University-Stanford University, National Institute for Public Health and the Environment [Bilthoven] (RIVM), Erasmus University Medical Center [Rotterdam] (Erasmus MC), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Humboldt University Of Berlin, Berlin Institute of Health (BIH), The University of Texas Medical Branch (UTMB), Institut Pasteur de Dakar, Réseau International des Instituts Pasteur (RIIP), Hôpital d'Instruction des Armées Laveran, Service de Santé des Armées, Heidelberg University Hospital [Heidelberg], Etablissement Français du Sang - Alpes-Méditerranée (EFS - Alpes-Méditerranée), Etablissement Français du Sang, Arbovirus et Insectes Vecteurs - Arboviruses and Insect Vectors, Institut Pasteur [Paris] (IP), Institut Pasteur du Cambodge, Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ), University of California [San Francisco] (UC San Francisco), University of California (UC), Washington University in Saint Louis (WUSTL), Public Health Agency of Canada, MRC - University of Glasgow Centre for Virus Research, Université Paris Descartes - Paris 5 (UPD5), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Biologie des Infections - Biology of Infection, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Agency for science, technology and research [Singapore] (A*STAR), Universidade Federal da Bahia (UFBA), U.S. Food and Drug Administration (FDA), Universidad Tecnológica de Pereira [Colombie] (UTP), Institut Pasteur de la Guadeloupe, Publication fees were covered by the Global Research Collaboration for Infectious Disease Preparedness (GloPID-R)., Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pascal Paoli (UPP), Humboldt-Universität zu Berlin, Institut Pasteur [Paris], Fundação Oswaldo Cruz (FIOCRUZ), University of California [San Francisco] (UCSF), University of California, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Virology, and DEMESLAY GOUGAM, MARIE

Subjects
0301 basic medicine, GloPID-R chikungunya, o'nyong-nyong and Mayaro virus Working Group, Genes, Viral, Iron, 030106 microbiology, Prevalence, Alphavirus, medicine.disease_cause, Disease Outbreaks, 03 medical and health sciences, Seroepidemiologic Studies, Virology, Environmental health, medicine, Seroprevalence, Animals, Humans, O'nyong-nyong Virus, Serologic Tests, Chikungunya, Phylogeny, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Pharmacology, Molecular epidemiology, Alphavirus Infections, Outbreak, 3. Good health, 030104 developmental biology, Geography, Infectious disease (medical specialty), [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Africa, Chikungunya Fever, Chikungunya virus
Abstract

The GloPID-R (Global Research Collaboration for Infectious Disease Preparedness) chikungunya (CHIKV), o'nyong-nyong (ONNV) and Mayaro virus (MAYV) Working Group has been established to identify gaps of knowledge about the natural history, epidemiology and medical management of infection by these viruses, and to provide adapted recommendations for future investigations. Here, we present a report dedicated to ONNV epidemiological distribution. Two large-scale ONNV outbreaks have been identified in Africa in the last 60 years, interspersed with sporadic serosurveys and case reports of returning travelers. The assessment of the real scale of ONNV circulation in Africa remains a difficult task and surveillance studies are necessary to fill this gap. The identification of ONNV etiology is made complicated by the absence of multiplex tools in co-circulation areas and that of reference standards, as well as the high cross-reactivity with related pathogens observed in serological tests, in particular with CHIKV. This is a specific obstacle for seroprevalence studies, that necessitate an improvement of serological tools to provide robust results. The scarcity of existent genetic data currently limits molecular epidemiology studies. ONNV epidemiology would also benefit from reinforced entomological and environmental surveillance. Finally, the natural history of the disease deserves to be further investigated, with a specific attention paid to long-term complications. Considering our incomplete knowledge on ONNV distribution, GloPID-R CHIKV, ONNV and MAYV experts recommend that a major effort should be done to fill existing gaps. ispartof: ANTIVIRAL RESEARCH vol:172 ispartof: location:Netherlands status: published

Published
2019
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24. GloPID-R report on Chikungunya, O'nyong-nyong and Mayaro virus, part I: Biological diagnostics

Author

A. J. Rodriguez-Morales, M. G. Rosa-Freitas, Guilherme S. Ribeiro, Nikos Vasilakis, Lisa F. P. Ng, Mariama Dalanda Diallo, Scott C. Weaver, Patrícia Brasil, Jan Felix Drexler, Johan Neyts, Anna-Bella Failloux, François Simon, Alain Kohl, A. Vega Rua, Maria Rios, Michael P. Busch, Michael S. Diamond, André Siqueira, Michael A. Drebot, P. Gallian, Sébastien Boyer, Ricardo Lourenço-de-Oliveira, Chantal Reusken, Angelle Desiree LaBeaud, Thomas Jaenisch, Marc Lecuit, Laura Pezzi, X. de Lamballerie, Graham Simmons, Amadou A. Sall, Unité des Virus Emergents (UVE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Virologie [UNIV Corse-Inserm] (EA7310), Université Pascal Paoli (UPP)-Institut National de la Santé et de la Recherche Médicale (INSERM), National Institute for Public Health and the Environment [Bilthoven] (RIVM), Erasmus University Medical Center [Rotterdam] (Erasmus MC), The University of Texas Medical Branch (UTMB), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Humboldt University Of Berlin, Berlin Institute of Health (BIH), German Centre for Infection Research (DZIF), University of California [San Francisco] (UC San Francisco), University of California (UC), Stanford School of Medicine [Stanford], Stanford Medicine, Stanford University-Stanford University, Washington University in Saint Louis (WUSTL), Public Health Agency of Canada, Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP), Universidade Federal da Bahia (UFBA), University of Glasgow, Biologie des Infections - Biology of Infection, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Imagine - Institut des maladies génétiques (IMAGINE - U1163), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Descartes - Paris 5 (UPD5), Agency for science, technology and research [Singapore] (A*STAR), Etablissement Français du Sang - Alpes-Méditerranée (EFS - Alpes-Méditerranée), Etablissement Français du Sang, Institut Pasteur du Cambodge, Institut Pasteur de Dakar, Arbovirus et Insectes Vecteurs - Arboviruses and Insect Vectors, Institut Pasteur [Paris] (IP), Heidelberg University Hospital [Heidelberg], Rega Institute for Medical Research [Leuven, België], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), U.S. Food and Drug Administration (FDA), Universidad Tecnológica de Pereira [Colombie] (UTP), Hôpital d'Instruction des Armées Laveran, Service de Santé des Armées, Institut Pasteur de la Guadeloupe, Publication fees were covered by the Global Research Collaboration for Infectious Disease Preparedness (GloPID-R)., Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pascal Paoli (UPP), Humboldt-Universität zu Berlin, University of California [San Francisco] (UCSF), University of California, Fundação Oswaldo Cruz (FIOCRUZ), Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pasteur [Paris], Virology, Charité - Universitätsmedizin Berlin / Charite - University Medicine Berlin, Humboldt Universität zu Berlin, Stanford University School of Medicine [Stanford], Stanford University [Stanford], Washington University in St Louis, Federal University of Bahia, Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Arbovirus et Insectes Vecteurs, and Rega Institute for Medical Research

Subjects
0301 basic medicine, medicine.medical_specialty, Genes, Viral, 030106 microbiology, Disease, Alphavirus, Mosquito Vectors, Cross Reactions, medicine.disease_cause, Antibodies, Viral, Communicable Diseases, Emerging, Virus, 03 medical and health sciences, Seroepidemiologic Studies, Virology, O'nyong-nyong, Epidemiology, medicine, Animals, Humans, O'nyong-nyong Virus, Chikungunya, Pathology, Molecular, Diagnostics, Phylogeny, Pharmacology, biology, business.industry, Alphavirus Infections, Outbreak, biology.organism_classification, Mayaro virus, 3. Good health, 030104 developmental biology, Cryoglobulinemia, Infectious disease (medical specialty), Preparedness, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Chikungunya Fever, business, Chikungunya virus
Abstract

The GloPID-R (Global Research Collaboration for Infectious Disease Preparedness) Chikungunya (CHIKV), O'nyong-nyong (ONNV) and Mayaro virus (MAYV) Working Group is investigating the natural history, epidemiology and medical management of infection by these viruses, to identify knowledge gaps and to propose recommendations for direct future investigations and rectification measures. Here, we present the first report dedicated to diagnostic aspects of CHIKV, ONNV and MAYV. Regarding diagnosis of the disease at the acute phase, molecular assays previously described for the three viruses require further evaluation, standardized protocols and the availability of international standards representing the genetic diversity of the viruses. Detection of specific IgM would benefit from further investigations to clarify the extent of cross-reactivity among the three viruses, the sensitivity of the assays, and the possible interfering role of cryoglobulinaemia. Implementation of reference panels and external quality assessments for both molecular and serological assays is necessary. Regarding sero-epidemiological studies, there is no reported high-throughput assay that can distinguish among these different viruses in areas of potential co-circulation. New specific tools and/or improved standardized protocols are needed to enable large-scale epidemiological studies of public health relevance to be performed. Considering the high risk of future CHIKV, MAYV and ONNV outbreaks, the Working Group recommends that a major investigation should be initiated to fill the existing diagnostic gaps. ispartof: ANTIVIRAL RESEARCH vol:166 pages:66-81 ispartof: location:Netherlands status: published

Published
2019
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25. GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 5: Entomological aspects

Author

Pezzi, L., Diallo, M., Rosa-Freitas, M. G., Vega-Rua, A., Ng, L. F. P., Boyer, S., Drexler, J. F., Vasilakis, N., Lourenco-de-Oliveira, R., Weaver, S. C., Kohl, A., de Lamballerie, X., Failloux, A-B, Brasil, P., Busch, M., Diamond, M. S., Drebot, M. A., Gallian, P., Jaenisch, T., LaBeaud, A. D., Lecui, M., Neyts, J., Reusken, C. B., Ribeiro, G. S., Rios, M., Rodriguez-Morales, A. J., Sall, A., Simmons, G., Simon, F., Siqueira, A. M., Pezzi, L., Diallo, M., Rosa-Freitas, M. G., Vega-Rua, A., Ng, L. F. P., Boyer, S., Drexler, J. F., Vasilakis, N., Lourenco-de-Oliveira, R., Weaver, S. C., Kohl, A., de Lamballerie, X., Failloux, A-B, Brasil, P., Busch, M., Diamond, M. S., Drebot, M. A., Gallian, P., Jaenisch, T., LaBeaud, A. D., Lecui, M., Neyts, J., Reusken, C. B., Ribeiro, G. S., Rios, M., Rodriguez-Morales, A. J., Sall, A., Simmons, G., Simon, F., and Siqueira, A. M.

Abstract

The GloPID-R (Global Research Collaboration for Infectious Disease Preparedness) chikungunya (CHIKV), o'nyong-nyong (ONNV) and Mayaro virus (MAYV) Working Group has been established to investigate natural history, epidemiology and clinical aspects of infection by these viruses. Here, we present a report dedicated to entomological aspects of CHIKV, ONNV and MAYV. Recent global expansion of chikungunya virus has been possible because CHIKV established a transmission cycle in urban settings using anthropophilic vectors such as Aedes albopictus and Aedes aegypti. MAYV and ONNV have a more limited geographic distribution, being confined to Africa (ONNV) and central-southern America (MAYV). ONNV is probably maintained through an enzootic cycle that has not been characterized yet, with Anopheles species as main vectors and humans as amplification hosts during epidemics. MAYV is transmitted by Haemagogus species in an enzootic cycle using non-human primates as the main amplification and maintenance hosts, and humans becoming sporadically infected when venturing in or nearby forest habitats. Here, we focused on the transmission cycle and natural vectors that sustain circulation of these viruses in their respective locations. The knowledge of the natural ecology of transmission and the capacity of different vectors to transmit these viruses is crucial to understand CHIKV emergence, and to assess the risk that MAYV and ONNV will expand on wide scale using anthropophilic mosquito species not normally considered primary vectors. Finally, the experts identified knowledge gaps and provided adapted recommendations, in order to address future entomological investigations in the right direction.

Published
2020

26. GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 5: Entomological aspects

Author

Pezzi, L. (L.), Diallo, M. (M.), Rosa-Freitas, M.G. (M. G.), Vega-Rua, A. (A.), Ng, L.F.P. (L. F.P.), Boyer, S. (S.), Drexler, J.-F. (Jan-Felix), Vasilakis, N. (Nikos), Lourenco-de-Oliveira, R. (R.), Weaver, S.C. (S. C.), Kohl, A. (A.), de Lamballerie, X. (X.), Failloux, A.-B. (A. B.), Brasil, P. (P.), Busch, M. (M.), Diamond, M.S. (M. S.), Drebot, M.A. (M. A.), Gallian, P. (P.), Jaenisch, T. (T.), LaBeaud, A.D. (A. D.), Lecuit, M. (M.), Neyts, J. (J.), Reusken, C.B.E.M. (Chantal), Ribeiro, G.S. (G. S.), Rios, M. (M.), Rodriguez-Morales, A.J. (A. J.), Sall, A. (A.), Simmons, G. (G.), Simon, F. (F.), Siqueira, A.M. (A. M.), Pezzi, L. (L.), Diallo, M. (M.), Rosa-Freitas, M.G. (M. G.), Vega-Rua, A. (A.), Ng, L.F.P. (L. F.P.), Boyer, S. (S.), Drexler, J.-F. (Jan-Felix), Vasilakis, N. (Nikos), Lourenco-de-Oliveira, R. (R.), Weaver, S.C. (S. C.), Kohl, A. (A.), de Lamballerie, X. (X.), Failloux, A.-B. (A. B.), Brasil, P. (P.), Busch, M. (M.), Diamond, M.S. (M. S.), Drebot, M.A. (M. A.), Gallian, P. (P.), Jaenisch, T. (T.), LaBeaud, A.D. (A. D.), Lecuit, M. (M.), Neyts, J. (J.), Reusken, C.B.E.M. (Chantal), Ribeiro, G.S. (G. S.), Rios, M. (M.), Rodriguez-Morales, A.J. (A. J.), Sall, A. (A.), Simmons, G. (G.), Simon, F. (F.), and Siqueira, A.M. (A. M.)

Abstract

The GloPID-R (Global Research Collaboration for Infectious Disease Preparedness) chikungunya (CHIKV), o'nyong-nyong (ONNV) and Mayaro virus (MAYV) Working Group has been established to investigate natural history, epidemiology and clinical aspects of infection by these viruses. Here, we present a report dedicated to entomological aspects of CHIKV, ONNV and MAYV. Recent global expansion of chikungunya virus has been possible because CHIKV established a transmission cycle in urban settings using anthropophilic vectors such as Aedes albopictus and Aedes aegypti. MAYV and ONNV have a more limited geographic distribution, being confined to Africa (ONNV) and central-southern America (MAYV). ONNV is probably maintained through an enzootic cycle that has not been characterized yet, with Anopheles species as main vectors and humans as amplification hosts during epidemics. MAYV is transmitted by Haemagogus species in an enzootic cycle using non-human primates as the main amplification and maintenance hosts, and humans becoming sporadically infected when venturing

Published
2020
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28. In vivo Zika virus detection in human skin

Author

Vivien Hébert, A. Vega Rua, C. Herrmann-Storck, N. Cordel, CHU Pointe-à-Pitre/Abymes [Guadeloupe], Physiopathologie, Autoimmunité, maladies Neuromusculaires et THErapies Régénératrices (PANTHER), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université des Antilles (Pôle Guadeloupe), Université des Antilles (UA), Service de Dermatologie [Rouen], Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Normandie Université (NU), Institut Pasteur de la Guadeloupe, Réseau International des Instituts Pasteur (RIIP), We are grateful to Nikki Sabourin‐Gibbs, Rouen University Hospital, for her help in editing the manuscript., and We thank all of the patients involved for granting permission to explore a part of their skin biopsy specimen virologically and to publish the resulting data.

Subjects
0301 basic medicine, Sexual transmission, Aedes albopictus, [SDV]Life Sciences [q-bio], education, MESH: Skin/virology, MESH: Zika Virus/isolation & purification, Viremia, Dermatology, Aedes aegypti, Zika virus, 03 medical and health sciences, 0302 clinical medicine, MESH: RNA, Viral/isolation & purification, medicine, 030212 general & internal medicine, MESH: Zika Virus Infection/diagnosis, ComputingMilieux_MISCELLANEOUS, MESH: Skin Diseases, Viral/diagnosis, Tropism, MESH: Humans, MESH: Middle Aged, biology, Transmission (medicine), virus diseases, MESH: Adult, biology.organism_classification, medicine.disease, Virology, MESH: Male, 3. Good health, Flavivirus, 030104 developmental biology, Immunology, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, [SDV.IMM]Life Sciences [q-bio]/Immunology, MESH: Female
Abstract

Zika virus (ZIKAV) a Flavivirus mainly transmitted by Aedes aegypti and Aedes albopictus mosquitoes has been responsible for an extensive epidemic affecting people in more than 56 countries since its emergence in Brazil in 2015 (1). Evidence of the neuroinvasiveness and the tropism of ZIKAV for placenta trophoblasts has turned an infection, originally known for its mildness, into a major world public health concern due to the severity and dissemination of associated disorders (i.e.: congenital Zika syndrome and Guillain Barre syndrome) (2). Despite a commonly short viremia of low intensity the spread of ZIKAV infection is primarily due to vectorial transmission rather than to vertical or sexual transmission which have recently been evidenced (3-5). This article is protected by copyright. All rights reserved.

Published
2017
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29. Influence of breeding sites bacterial communities on Aedes aegypti microbiome and vector competence for dengue and Zika viruses

Author

Hery, Lyza, Boullis, Antoine, Dollin, Christelle, Breurec, Sebastien, Vega Rua, Anubis, Gros, Olivier, Institut Pasteur de la Guadeloupe, Réseau International des Instituts Pasteur (RIIP), and CHU Pointe-à-Pitre/Abymes [Guadeloupe]

Subjects
[SDE.BE] Environmental Sciences/Biodiversity and Ecology, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2019

30. GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 3: Epidemiological distribution of Mayaro virus

Author

Pezzi, L., Rodriguez-Morales, A.J., Reusken, C.B., Ribeiro, G.S., Labeaud, A.D., Lourenço-De-Oliveira, R., Brasil, P., Lecuit, M., Failloux, Anna-Bella, Gallian, P., Jaenisch, T., Simon, F., Siqueira, A.M., Rosa-Freitas, M.G., Vega Rua, A., Weaver, S.C., Drexler, J.F., Vasilakis, N., de Lamballerie, Xavier, Boyer, Sébastien, Busch, M., Diallo, M., Diamond, M.S., Drebot, M.A., Kohl, A., Neyts, J., Ng, L.F.P., Rios, M., Sall, A., Simmons, G., Virology, Unité des Virus Emergents (UVE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Virologie [UNIV Corse-Inserm] (EA7310), Université Pascal Paoli (UPP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Universidad Tecnológica de Pereira [Colombie] (UTP), National Institute for Public Health and the Environment [Bilthoven] (RIVM), Erasmus University Medical Center [Rotterdam] (Erasmus MC), Universidade Federal da Bahia (UFBA), Stanford School of Medicine [Stanford], Stanford Medicine, Stanford University-Stanford University, Fundação Oswaldo Cruz (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP), Biologie des Infections - Biology of Infection, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Descartes - Paris 5 (UPD5), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Arbovirus et Insectes Vecteurs - Arboviruses and Insect Vectors, Institut Pasteur [Paris] (IP), Etablissement Français du Sang - Alpes-Méditerranée (EFS - Alpes-Méditerranée), Etablissement Français du Sang, Heidelberg University Hospital [Heidelberg], Hôpital d'Instruction des Armées Laveran, Service de Santé des Armées, Institut Pasteur de la Guadeloupe, The University of Texas Medical Branch (UTMB), German Center for Infection Research - partner site Hannover-Braunschweig (DZIF), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Humboldt University Of Berlin, Berlin Institute of Health (BIH), Institut Pasteur du Cambodge, University of California [San Francisco] (UC San Francisco), University of California (UC), Institut Pasteur de Dakar, Washington University in Saint Louis (WUSTL), Public Health Agency of Canada, MRC - University of Glasgow Centre for Virus Research, Laboratory of Virology and Chemotherapy [KU Leuven], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven)-Rega Institute of Medical Research [Leuven, Belgium], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Agency for science, technology and research [Singapore] (A*STAR), U.S. Food and Drug Administration (FDA), Publication fees were covered by the Global Research Collaboration for Infectious Disease Preparedness (GloPID-R)., DEMESLAY GOUGAM, MARIE, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pascal Paoli (UPP), Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Institut Pasteur [Paris], Humboldt-Universität zu Berlin, University of California [San Francisco] (UCSF), University of California, and Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ)

Subjects
Primates, GloPID-R chikungunya, o'nyong-nyong and Mayaro virus Working Group, 030231 tropical medicine, Alphavirus, Genome, Viral, Mosquito Vectors, Disease Outbreaks, 03 medical and health sciences, 0302 clinical medicine, Seroepidemiologic Studies, Virology, Zoonoses, Animals, Humans, O'nyong-nyong Virus, Serologic Tests, 030212 general & internal medicine, Pathology, Molecular, ComputingMilieux_MISCELLANEOUS, Phylogeny, Disease Reservoirs, Pharmacology, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Alphavirus Infections, 3. Good health, Caribbean Region, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Chikungunya Fever, Americas, Chikungunya virus
Abstract

ispartof: ANTIVIRAL RESEARCH vol:172 ispartof: location:Netherlands status: published

Published
2019
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31. Aedes aegypti mosquitoes from Guadeloupe (French West Indies) are able to transmit yellow fever virus

Author

Pei-Shi Yen, Fadila Amraoui, Anna-Bella Failloux, Anubis Vega Rua, Arbovirus et Insectes Vecteurs - Arboviruses and Insect Vectors, Institut Pasteur [Paris] (IP), Institut Pasteur de la Guadeloupe, Réseau International des Instituts Pasteur (RIIP), ABF was funded by French Government’s Investissement d’Avenir program, Laboratoire d’Excellence 'Integrative Biology of Emerging Infectious Diseases' (grant n°ANR-10-LABX-62-IBEID), AVR was funded by FEDER grant that financed by the European Union and Guadeloupe Region, Programme Opérationnel FEDER-Guadeloupe-Conseil Régional 2014-2020 (Grant number 2015-FED-192). P-SY was supported by the Institut Pasteur and the National Health Research Institutes in Taiwan., We thank Laurence Mousson and Marie Vazeille for technical help, Cédric Ramdini and Joel Gustave for their support during mosquito sampling campaigns, and Pedro Fernando da Costa Vasconselos for providing the viral strain., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), European Project: 2015-FED-192,FEDER-Guadeloupe, and Institut Pasteur [Paris]

Subjects
0301 basic medicine, Viral vectors, Veterinary medicine, Physiology, lcsh:Medicine, Mosquito saliva, Disease Vectors, Mosquitoes, Geographical locations, 0302 clinical medicine, Aedes aegypti, Aedes, Medicine and Health Sciences, lcsh:Science, Guadeloupe, West indies, Multidisciplinary, biology, Yellow fever, Eukaryota, 3. Good health, Body Fluids, Insects, Infectious Diseases, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Anatomy, Yellow fever virus, Brazil, Research Article, Arthropoda, 030231 tropical medicine, education, Microbiology, Virus, 03 medical and health sciences, Caribbean region, Virology, Yellow Fever, medicine, Vector-borne diseases, Animals, Humans, Saliva, Caribbean, lcsh:R, fungi, Organisms, Outbreak, Biology and Life Sciences, South America, biology.organism_classification, medicine.disease, Invertebrates, Insect Vectors, Species Interactions, 030104 developmental biology, North America, lcsh:Q, People and places, Viral Transmission and Infection
Abstract

International audience; The recent yellow fever epidemic in Brazil has raised the concern of outbreaks in neighboring countries, particularly in the Caribbean region where the vector Aedes aegypti is predominant. This threat comes from the past when in the Americas, this disease caused devastating urban epidemics. We report the vector competence of Ae. aegypti from Guade-loupe for yellow fever virus by determining different parameters describing virus infection, dissemination, and transmission. The results indicate that Ae. aegypti Guadeloupe are susceptible to yellow fever virus with viral particles detected in mosquito saliva at 14 and 21 days post-infection. Local authorities and more broadly, international organizations should maintain the active surveillance of Aedes mosquitoes and the spreading of human cases from South America.

Published
2018
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32. GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 2: Epidemiological distribution of o'nyong-nyong virus

Author

Pezzi, L., primary, LaBeaud, A.D., additional, Reusken, C.B., additional, Drexler, J.F., additional, Vasilakis, N., additional, Diallo, M., additional, Simon, F., additional, Jaenisch, T., additional, Gallian, P., additional, Sall, A., additional, Failloux, A.B., additional, Weaver, S.C., additional, de Lamballerie, X., additional, Boyer, S., additional, Brasil, P., additional, Busch, M., additional, Diamond, M.S., additional, Drebot, M.A., additional, Kohl, A., additional, Lecuit, M., additional, Lourenço-de-Oliveira, R., additional, Neyts, J., additional, Lfp, Ng, additional, Ribeiro, G.S., additional, Rios, M., additional, Rodriguez-Morales, A.J., additional, Rosa-Freitas, M.G., additional, Simmons, G., additional, Siqueira, A.M., additional, and Vega Rua, A., additional

Published
2019
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33. GloPID-R report on Chikungunya, O'nyong-nyong and Mayaro virus, part I: Biological diagnostics

Author

Pezzi, L., primary, Reusken, C.B., additional, Weaver, S.C., additional, Drexler, J.F., additional, Busch, M., additional, LaBeaud, A.D., additional, Diamond, M.S., additional, Vasilakis, N., additional, Drebot, M.A., additional, Siqueira, A.M., additional, Ribeiro, G.S., additional, Kohl, A., additional, Lecuit, M., additional, Ng, L.F.P., additional, Gallian, P., additional, de Lamballerie, X., additional, Boyer, S., additional, Brasil, P., additional, Diallo, M., additional, Failloux, A.B., additional, Jaenisch, T., additional, Lourenço-de-Oliveira, R., additional, Neyts, J., additional, Rios, M., additional, Rodriguez-Morales, A.J., additional, Rosa-Freitas, M.G., additional, Sall, A., additional, Simmons, G., additional, Simon, F., additional, and Vega Rua, A., additional

Published
2019
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34. GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 3: Epidemiological distribution of Mayaro virus

Author

Pezzi, L. (L.), Rodriguez-Morales, A.J. (A. J.), Reusken, C.B.E.M. (Chantal), Ribeiro, G.S. (G. S.), LaBeaud, A.D. (A. D.), Lourenço-de-Oliveira, R. (R.), Brasil, P. (P.), Lecuit, M. (M.), Failloux, A.B. (A. B.), Gallian, P. (P.), Jaenisch, T. (T.), Simon, F. (F.), Siqueira, A.M. (A. M.), Rosa-Freitas, M.G. (M. G.), Vega Rua, A. (A.), Weaver, S.C. (S. C.), Drexler, J.-F. (Jan-Felix), Vasilakis, N. (Nikos), de Lamballerie X, (), Boyer, S. (S.), Busch, M. (M.), Diallo, M. (M.), Diamond, M.S. (M. S.), Drebot, M.A. (M. A.), Kohl, A. (A.), Neyts, J. (J.), Ng, L.F.P. (L. F.P.), Rios, M. (M.), Sall, A. (A.), Simmons, G. (G.), Pezzi, L. (L.), Rodriguez-Morales, A.J. (A. J.), Reusken, C.B.E.M. (Chantal), Ribeiro, G.S. (G. S.), LaBeaud, A.D. (A. D.), Lourenço-de-Oliveira, R. (R.), Brasil, P. (P.), Lecuit, M. (M.), Failloux, A.B. (A. B.), Gallian, P. (P.), Jaenisch, T. (T.), Simon, F. (F.), Siqueira, A.M. (A. M.), Rosa-Freitas, M.G. (M. G.), Vega Rua, A. (A.), Weaver, S.C. (S. C.), Drexler, J.-F. (Jan-Felix), Vasilakis, N. (Nikos), de Lamballerie X, (), Boyer, S. (S.), Busch, M. (M.), Diallo, M. (M.), Diamond, M.S. (M. S.), Drebot, M.A. (M. A.), Kohl, A. (A.), Neyts, J. (J.), Ng, L.F.P. (L. F.P.), Rios, M. (M.), Sall, A. (A.), and Simmons, G. (G.)

Published
2019
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35. GloPID-R report on chikungunya, o'nyong-nyong and Mayaro virus, part 2: Epidemiological distribution of o'nyong-nyong virus

Author

Pezzi, L. (L.), LaBeaud, A.D. (A. D.), Reusken, C.B.E.M. (Chantal), Drexler, J.-F. (Jan-Felix), Vasilakis, N. (Nikos), Diallo, M. (M.), Simon, F. (F.), Jaenisch, T. (T.), Gallian, P. (P.), Sall, A. (A.), Failloux, A.B. (A. B.), Weaver, S.C. (S. C.), de Lamballerie, X. (Xavier), Boyer, S. (S.), Brasil, P. (P.), Busch, M. (M.), Diamond, M.S. (M. S.), Drebot, M.A. (M. A.), Kohl, A. (A.), Lecuit, M. (M.), Lourenço-de-Oliveira, R. (R.), Neyts, J. (J.), Lfp, N. (Ng), Ribeiro, G.S. (G. S.), Rios, M. (M.), Rodriguez-Morales, A.J. (A. J.), Rosa-Freitas, M.G. (M. G.), Simmons, G. (G.), Siqueira, A.M. (A. M.), Vega Rua, A. (A.), Pezzi, L. (L.), LaBeaud, A.D. (A. D.), Reusken, C.B.E.M. (Chantal), Drexler, J.-F. (Jan-Felix), Vasilakis, N. (Nikos), Diallo, M. (M.), Simon, F. (F.), Jaenisch, T. (T.), Gallian, P. (P.), Sall, A. (A.), Failloux, A.B. (A. B.), Weaver, S.C. (S. C.), de Lamballerie, X. (Xavier), Boyer, S. (S.), Brasil, P. (P.), Busch, M. (M.), Diamond, M.S. (M. S.), Drebot, M.A. (M. A.), Kohl, A. (A.), Lecuit, M. (M.), Lourenço-de-Oliveira, R. (R.), Neyts, J. (J.), Lfp, N. (Ng), Ribeiro, G.S. (G. S.), Rios, M. (M.), Rodriguez-Morales, A.J. (A. J.), Rosa-Freitas, M.G. (M. G.), Simmons, G. (G.), Siqueira, A.M. (A. M.), and Vega Rua, A. (A.)

Abstract

The GloPID-R (Global Research Collaboration for Infectious Disease Preparedness) chikungunya (CHIKV), o'nyong-nyong (ONNV) and Mayaro virus (MAYV) Working Group has been established to identify gaps of knowledge about the natural history, epidemiology and medical management of infection by these viruses, and to provide adapted recommendations for future investigations. Here, we present a report dedicated to ONNV epidemiological distribution. Two large-scale ONNV outbreaks have been identified in Africa in the last 60 years, interspersed with sporadic serosurveys and case reports of returning travelers. The assessment of the real scale of ONNV circulation in Africa remains a difficult task and surveillance studies are necessary to fill this gap. The identification of ONNV etiology is made complicated by the absence of multiplex tools in co-circulatio

Published
2019
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36. Additional file 2: of Levels of insecticide resistance to deltamethrin, malathion, and temephos, and associated mechanisms in Aedes aegypti mosquitoes from the Guadeloupe and Saint Martin islands (French West Indies)

Author

Goindin, Daniella, Delannay, Christelle, Andric Gelasse, Ramdini, Cédric, Gaude, Thierry, Faucon, Frédéric, Jean-Philippe David, Gustave, Joël, Anubis Vega-Rua, and Fouque, Florence

Abstract

Set of primers used for the expression and amplification of detoxification enzymes q-PCR. (DOCX 14 kb)

Published
2017
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37. Additional file 1: of Levels of insecticide resistance to deltamethrin, malathion, and temephos, and associated mechanisms in Aedes aegypti mosquitoes from the Guadeloupe and Saint Martin islands (French West Indies)

Author

Goindin, Daniella, Delannay, Christelle, Andric Gelasse, Ramdini, Cédric, Gaude, Thierry, Faucon, Frédéric, Jean-Philippe David, Gustave, Joël, Anubis Vega-Rua, and Fouque, Florence

Abstract

s in the six official working languages of the United Nations. (PDF 760 kb)

Published
2017
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38. Differential Susceptibilities of Aedes aegypti and Aedes albopictus From the Americas to Zika Virus

Author

Chouin-Carneiro, Thais and Vega-Rua, Anubis

Abstract

Since the major outbreak in 2007 in the Yap Island, Zika virus (ZIKV) causing dengue-like syndromes has affected multiple islands of the South Pacific region. In May 2015, the virus was detected in Brazil and then spread through South and Central America. In December 2015, ZIKV was detected in French Guiana and Martinique. The aim of the study was to evaluate the vector competence of the mosquito spp. Aedes aegypti and Aedes albopictus from the Caribbean (Martinique, Guadeloupe), North America (southern United States), South America (Brazil, French Guiana) for the currently circulating Asian genotype of ZIKV isolated from a patient in April 2014 in New Caledonia.

Published
2016

40. Levels of insecticide resistance to deltamethrin, malathion, and temephos, and associated mechanisms in Aedes aegypti mosquitoes from the Guadeloupe and Saint Martin islands (French West Indies)

Author

Goindin, Daniella, primary, Delannay, Christelle, additional, Gelasse, Andric, additional, Ramdini, Cédric, additional, Gaude, Thierry, additional, Faucon, Frédéric, additional, David, Jean-Philippe, additional, Gustave, Joël, additional, Vega-Rua, Anubis, additional, and Fouque, Florence, additional

Published
2017
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41. Chikungunya virus emergence in the Americas and Europe

Author

Vega Rua, Anubis, STAR, ABES, Arbovirus et Insectes Vecteurs - Arboviruses and Insect Vectors, Institut Pasteur [Paris], Université Pierre et Marie Curie - Paris VI, Anna-Bella Failloux, and Institut Pasteur [Paris] (IP)

Subjects
Europe, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Aedes aegypti, Compétence vectorielle, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Chikungunya, Amériques, Aedes albopictus, Chikungunya virus, Vector competence
Abstract

Chikungunya virus (CHIKV), transmitted mainly by the mosquitoes Aedes aegypti and Aedes albopictus, is a major public health problem. Since 2004, CHIKV epidemics have been reported in Africa, Asia, the Indian Ocean Islands, and Europe. Only the Americas seemed spared despite high densities of mosquitoes and multiple introductions of the virus to the continent by travelers returning from countries where CHIKV was circulating. We have assessed the risk of CHIKV emergence in the Americas by evaluating the vector competence of 35 local populations of Ae. aegypti and Ae. albopictus infected with different strains of CHIKV. These populations were shown to be susceptible to CHIKV infection, highlighting the predominant role of salivary glands as a "filter" of transmission. Genotyping of Ae. albopictus from the Americas using microsatellites allowed the identification of a genetic cluster of populations characterized by a low transmission of CHIKV strains of the East-Central-South-African genotype. In October 2013, Asian strains of CHIKV began circulating in the Caribbean. Thus, we evaluated the susceptibility of 11 populations of Ae. aegypti and Ae. albopictus to the Asian CHIKV genotype and showed that the two species were sufficiently competent to ensure dissemination of the virus throughout the continent. Furthermore, we showed that Ae. albopictus was likely to facilitate the spread of CHIKV to Europe. However, the vector competence of French Ae. albopictus to the Asian CHIKV genotype was negatively affected by temperatures lower than those usually found in tropical countries., Le virus chikungunya (CHIKV), transmis par les moustiques Aedes aegypti et Aedes albopictus, constitue un problème majeur de santé publique. Depuis 2004, des épidémies de CHIKV ont été rapportées en Afrique, en Asie, dans les îles de l'Océan Indien, et en Europe. Seule l'Amérique semblait épargnée malgré la présence de fortes densités de moustiques vecteurs et de multiples importations du virus dans le continent par des voyageurs de retour de pays où le virus circulait. Nous avons abordé dans cette thèse le risque d'émergence du CHIKV en Amérique à partir d'une évaluation de la compétence vectorielle de 35 populations d'Ae. aegypti et Ae. albopictus locaux avec différentes souches de CHIKV. Ces populations sont compétentes vis-à-vis du CHIKV avec un rôle des glandes salivaires comme "filtre" de la transmission. De plus, le génotypage des Ae. albopictus d'Amérique par microsatellites a permis d'identifier un cluster génétique de populations se caractérisant par une faible transmission des souches de CHIKV de génotype Est-Centre-Sud-africain. En octobre 2013, des souches asiatiques de CHIKV ont été signalées dans la Caraïbe. Nous avons alors évalué la réceptivité de 11 populations d'Ae. aegypti et Ae. albopictus d'Amérique vis-à-vis de CHIKV de génotype asiatique et avons mis en évidence que les deux espèces étaient compétents pour assurer la diffusion du virus sur le continent. On note aussi qu'Ae. albopictus peut faciliter la propagation du CHIKV vers l'Europe. Néanmoins, la compétence vectorielle d'Ae. albopictus de France vis-à-vis de CHIKV asiatique est affectée négativement par des températures plus basses que celles habituellement observées dans les pays tropicaux.

Published
2015

44. Aedes aegypti from temperate regions of South America are highly competent to transmit dengue virus

Author

Darío Vezzani, Marie Vazeille, Laurence Mousson, Ricardo Lourenço-de-Oliveira, Anna-Bella Failloux, Anubis Vega Rua, Gabriela Willat, Laboratório de Mosquitos Transmissores de Hematozoários [Rio de Janeiro], Instituto Oswaldo Cruz / Oswaldo Cruz Institute [Rio de Janeiro] (IOC), Fundação Oswaldo Cruz (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Fundação Oswaldo Cruz (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Arbovirus et Insectes Vecteurs - Arboviruses and Insect Vectors, Institut Pasteur [Paris], Instituto de Ecología, Genética y Evolución de Buenos Aires (IEGEBA), Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET)-Facultad de Ciencias Exactas y Naturales [Buenos Aires] (FCEyN), Universidad de Buenos Aires [Buenos Aires] (UBA)-Universidad de Buenos Aires [Buenos Aires] (UBA), Unidad de Zoonosis y Vectores, Dirección General de la Salud, Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ), and Institut Pasteur [Paris] (IP)

Subjects
Male, Veterinary medicine, viruses, Dengue virus, medicine.disease_cause, Dengue fever, purl.org/becyt/ford/1 [https], Dengue, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Aedes, 0303 health sciences, ARGENTINA, biology, Transmission (medicine), Temperature, Zoología, Ornitología, Entomología, Etología, Viral Load, 3. Good health, Infectious Diseases, EXPERIMENTAL INFECTIONS, Female, CIENCIAS NATURALES Y EXACTAS, Research Article, DENGUE, 030231 tropical medicine, Argentina, Aedes aegypti, Ciencias Biológicas, 03 medical and health sciences, stomatognathic system, URUGUAY, parasitic diseases, medicine, Temperate climate, Animals, purl.org/becyt/ford/1.6 [https], 030304 developmental biology, Outbreak, Dengue Virus, biology.organism_classification, medicine.disease, Virology, VECTOR COMPETENCE, Insect Vectors, Vector (epidemiology), Experimental infections, Uruguay, Virología, Vector competence
Abstract

International audience; Background Aedes aegypti is extensively spread throughout South America where it has been responsible for large dengue epidemics during the last decades. Intriguingly, dengue transmission has not been reported in Uruguay and is essentially prevalent in subtropical northern Argentina which borders Uruguay.MethodsWe assessed vector competence for dengue virus (DENV) of Ae. aegypti populations collected in subtropical Argentina (Corrientes) as well as temperate Uruguay (Salto) and Argentina (Buenos Aires) in 2012 using experimental oral infections with DENV-2. Mosquitoes were incubated at 28°C and examined at 14 and 21 days p.i. to access viral dissemination and transmission. Batches of the Buenos Aires mosquitoes were also incubated at 15°C and 20°C.ResultsAlthough mosquitoes from temperate Uruguay and Argentina were competent to transmit DENV, those from subtropical Argentina were more susceptible, displaying the highest virus titters in the head and presenting the highest dissemination of infection and transmission efficiency rates when incubated at 28°C. Interestingly, infectious viral particles could be detected in saliva of mosquitoes from Buenos Aires exposed to 15°C and 20°C.ConclusionsThere is a potential risk of establishing DENV transmission in Uruguay and for the spread of dengue outbreaks to other parts of subtropical and temperate Argentina, notably during spring and summer periods.

Published
2013
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45. <italic>In vivo</italic> Zika virus detection in human skin.

Author

Cordel, N., Hébert, V., Vega Rua, A., and Herrmann‐Storck, C.

Subjects
ZIKA virus infections, REVERSE transcriptase, POLYMERASE chain reaction, BIOPSY, TISSUE wounds
Abstract

The article offers information on a study on zika virus detection in human skin. It mentions amplification plots of Zika virus quantitative reverse-transcriptase polymerase chain reaction in both skin and serum for patients. it also mentions absence of control biopsies from unaffected skin, along with biopsies from lesional skin.

Published
2018
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46. High Efficiency of Temperate Aedes albopictus to Transmit Chikungunya and Dengue Viruses in the Southeast of France.

Author

Vega-Rua, Anubis, Zouache, Karima, Caro, Valerie, Diancourt, Laure, Delaunay, Pascal, Grandadam, Marc, and Failloux, Anna-Bella

Subjects
AEDES albopictus, CHIKUNGUNYA, DENGUE viruses, EPIDEMICS, ARBOVIRUSES, VIRUS diseases, HOST-parasite relationships
Abstract

Background: Since 2005, cases of chikungunya (CHIK) were caused by an unusual vector, Aedes albopictus. This mosquito, present in Europe since 1979, has gained importance since its involvement in the first CHIK outbreak in Italy in 2007. The species is capable of transmitting experimentally 26 arboviruses. However, the vectorial status of its temperate populations has remained little investigated. In 2010, autochthonous cases of CHIK and dengue (DEN) were reported in southeastern France. We evaluated the potential of a French population of Ae. albopictus in the transmission of both viruses. Methodology and Principal Findings: We used two strains of each virus, CHIK and DEN: one strain was isolated from an imported case, and one from an autochthonous case. We used as controls Aedes aegypti from India and Martinique, the source of the imported cases of CHIK and DEN, respectively. We showed that Ae. albopictus from Cagnes-sur-Mer (AL-CSM) was as efficient as the typical tropical vector Ae. aegypti from India to experimentally transmit both CHIK strains isolated from patients in Fréjus, with around 35–67% of mosquitoes delivering up to 14 viral particles at day 3 post-infection (pi). The unexpected finding came from the high efficiency of AL-CSM to transmit both strains of DENV-1 isolated from patients in Nice. Almost 67% of Ae. albopictus AL-CSM which have ensured viral dissemination were able to transmit at day 9 pi when less than 21% of the typical DEN vector Ae. aegypti from Martinique could achieve transmission. Conclusions/Significance: Temperate Ae. albopictus behaves differently compared to its counterpart from tropical regions, where recurrent epidemic outbreaks occur. Its potential responsibility for outbreaks in Europe should not be minimized. [ABSTRACT FROM AUTHOR]

Published
2013
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47. Aedes aegypti from temperate regions of South America are highly competent to transmit dengue virus.

Author

Lourenço-de-Oliveira, Ricardo, Vega Rua, Anubis, Vezzani, Darío, Willat, Gabriela, Vazeille, Marie, Mousson, Laurence, and Bella Failloux, Anna

Subjects
*AEDES aegypti, *DENGUE, *DENGUE viruses, *MOSQUITOES, *DISEASE susceptibility, *EPIDEMICS, *INFECTIOUS disease transmission
Abstract

Background Aedes aegypti is extensively spread throughout South America where it has been responsible for large dengue epidemics during the last decades. Intriguingly, dengue transmission has not been reported in Uruguay and is essentially prevalent in subtropical northern Argentina which borders Uruguay. Methods We assessed vector competence for dengue virus (DENV) of Ae. aegypti populations collected in subtropical Argentina (Corrientes) as well as temperate Uruguay (Salto) and Argentina (Buenos Aires) in 2012 using experimental oral infections with DENV-2. Mosquitoes were incubated at 28°C and examined at 14 and 21 days p.i. to access viral dissemination and transmission. Batches of the Buenos Aires mosquitoes were also incubated at 15°C and 20°C. Results Although mosquitoes from temperate Uruguay and Argentina were competent to transmit DENV, those from subtropical Argentina were more susceptible, displaying the highest virus titters in the head and presenting the highest dissemination of infection and transmission efficiency rates when incubated at 28°C. Interestingly, infectious viral particles could be detected in saliva of mosquitoes from Buenos Aires exposed to 15°C and 20°C. Conclusion There is a potential risk of establishing DENV transmission in Uruguay and for the spread of dengue outbreaks to other parts of subtropical and temperate Argentina, notably during spring and summer periods. [ABSTRACT FROM AUTHOR]

Published
2013
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