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Investigations were carried out at the multistage hybrid Ti:sapphire–KrF laser facility GARPUN-MTW on the direct amplification of TW-power picosecond UV laser pulses in e-beam-pumped KrF amplifiers and propagation along a 100 m laboratory air pass. The experiments identified the main nonlinear effects and their impact on the amplification efficiency, amplifier optics degradation, beam quality and focusability, and the evolution of radiation spectra. The research was performed towards an implementation of the shock-ignition concept of inertial-confinement fusion using krypton fluoride laser drivers.

Experiments at the GARPUN KrF laser facility and 2D simulations using the NUTCY code were performed to study the irradiation of metal and polymethyl methacrylate (PMMA) targets by 100 ns UV pulses at intensities up to 5 × 1012 W cm−2. In both targets, a deep crater of length 1 mm was produced owing to the 2D geometry of the supersonic propagation of the ablation front in condensed matter that was pushed sideways by a conical shock wave. Small-scale filamentation of the laser beam caused by thermal self-focusing of radiation in the crater-confined plasma was evidenced by the presence of a microcrater relief on the bottom of the main crater. In translucent PMMA, with a penetration depth for UV light of several hundred micrometers, a long narrow channel of length 1 mm and diameter 30 μm was observed emerging from the crater vertex. Similar channels with a length-to-diameter aspect ratio of ∼1000 were produced by a repeated-pulse KrF laser in PMMA and fused silica glass at an intensity of ∼109 W cm−2. This channel formation is attributed to the effects of radiation self-focusing in the plasma and Kerr self-focusing in a partially transparent target material after shallow-angle reflection by the crater wall. Experimental modeling of the initial stage of inertial confinement fusion-scale direct-drive KrF laser interaction with subcritical coronal plasmas from spherical and cone-type targets using crater-confined plasmas seems to be feasible with increased laser intensity above 1014 W cm−2.

We study a problem about the number of lattice plane tilings by the given area centrosymmetrical polyominoes. A polyomino is a connected plane geomatric figure formed by joiining a finite number of unit squares edge to edge. At present, various combinatorial enumeration problems connected to the polyomino are actively studied. There are some interesting problems on enuneration of various classes of polyominoes and enumeration of tilings of finite regions or a plane by polyominoes. In particular, the tiling is a lattice tiling if each tile can be mapped to any other tile by a translation which maps the whole tiling to itself. Earlier we proved that, for the number T(n) of a lattice plane tilings by polyominoes of an area n, holds the inequalities 2n−3 + 2[ n−3 2 ] ≤ T(n) ≤ C(n + 1)3 (2, 7)n+1 . In the present work we prove a similar estimate for the number of lattice tilings with an additional central symmetry. Let Tc(n) be a number of lattice plane tilings by a given area centrosymmetrical polyominoes such that its translation lattice is a sublattice of Z 2 . It is proved that C1( √ 2)n ≤ Tc(n) ≤ C2n 2 ( √ 2.68)n . In the proof of a lower bound we give an explicit construction of required lattice plane tilings. The proof of an upper bound is based on a criterion of the existence of lattice plane tiling by polyominoes, and on the theory of self-avoiding walks on a square lattice.

We study a problem of a number of lattice plane tilings by given area polyominoes. A polyomino is a connected plane geometric figure formed by joining edge to edge a finite number of unit squares. A tiling is a lattice tiling if each tile can be mapped to any other tile by translation which maps the whole tiling to itself. Let T(n) be a number of lattice plane tilings by given area polyominoes such that its translation lattice is a sublattice of Z². It is proved that 2n−3 + 2[ n−3 2 ] ≤ T(n) ≤ C(n + 1)3 (2.7)n+1. In the proof of a lower bound we give an explicit construction of required lattice plane tilings. The proof of an upper bound is based on a criterion of the existence of lattice plane tiling by polyomino and on the theory of self-avoiding walk. Also, it is proved that almost all polyominoes that give lattice plane tilings have sufficiently large perimeters.

BACKGROUND: Electrocardiography is one of the simplest, most widely used, inexpensive, and informative methods in functional diagnostics; yet, if performed poorly, its diagnostic value is sharply reduced. Several attempts were made to systematize errors and deviations in electrode application, but all concerned the most common options (rearrangement of red and yellow electrodes, yellow and green electrodes, and chest electrodes above or below the standard scheme). AIM: To create an electrocardiogram dataset with different options for transpositions and dispositions of electrodes during electrocardiogram recording. MATERIALS AND METHODS: The study included patients aged 1875 years (27 males and 22 females). All patients provided informed consent for electrocardiogram registration. During one visit, the cardiogram was recorded on the device Modular system for recording and remote transmission of electrocardiograms (EASY ECG) for each patient. RESULTS: In all, 488 electrocardiograms were recorded in 49 patients. The results obtained indicate a significant variability of the electrocardiogram pattern. Visual analysis of the electrocardiograms revealed no difficulties in determining the transposition associated with rearranging the leads on the arms (RY) in the thoracic C1C2. The placement of thoracic electrodes in contact cheek-to-cheek dispositions with the transfer of thoracic leads above or below two intercostals was reliably determined compared with the Wilson scheme. The transpositions of the yellow and green limb electrodes and the change in the position of the thoracic ones when they are lined up in a straight line, bullied between the ribs (curved), and confused in places C5 and C6 are difficult to determine even when comparing two cardiograms next to each other, with the correct and transpositional superposition of the electrodes. The initial changes on the electrocardiograms, physique type, breast size, or the presence of an implant most likely determine it. CONCLUSION: An electrocardiography dataset was obtained using various electrode dislocation variants. The dataset consists of a series of electrocardiograms obtained for each patient with several electrode placement options and contains both normal and pathological electrocardiograms.

Abstract First physics results of the BM@N experiment at the Nuclotron/NICA complex are presented on π + and K + meson production in interactions of an argon beam with fixed targets of C, Al, Cu, Sn and Pb at 3.2 A GeV. Transverse momentum distributions, rapidity spectra and multiplicities of π + and K + mesons are measured. The results are compared with predictions of theoretical models and with other measurements at lower energies.

Clinical physiology involves a complete, comprehensive, multilateral study of the functions of both affected and healthy organs, which allows us to assess the compensatory capabilities of the body. Artificial intelligence is increasingly being used in medicine, including in clinical physiology. This is facilitated by the increase in computing processing power, development of cloud services and datasets, and numerous scientific articles demonstrating the effectiveness and viability of such intelligent solutions. Although the approach to medical dataset development is generally similar, there are a number of key features and significant differences in clinical physiology. Artificial intelligence systems in clinical physiology may be effectively trained and applied in practice by following the recommendations in this study. The national standard of the Russian Federation GOST R 59921.9-2022, which has entered into force, is included in the set of standards Artificial Intelligence systems in clinical medicine and establishes additional requirements for data analysis algorithms and test methods of artificial intelligence systems used in the field of clinical physiology. A crucial feature of the created standard is its qualimetric type (i.e., it has a mandatory set of demonstration data). Russia is one of the first countries to start developing quasi-metric standards worldwide, and 15 industry standards in the field of artificial intelligence (2 of them in medicine) will come into force this year.

Abstract The main male hormone, testosterone is obtained from cheap and readily available phytosterol using the strains of Mycolicibacterium neoaurum VKM Ac-1815D, or Ac-1816D. During the first “oxidative” stage, phytosterol (5–10 g/L) was aerobically converted by Ac-1815D, or Ac-1816D to form 17-ketoandrostanes: androstenedione, or androstadienedione, respectively. At the same bioreactor, the 17-ketoandrostanes were further transformed to testosterone due to the presence of 17β-hydroxysteroid dehydrogenase activity in the strains (“reductive” mode). The conditions favorable for “oxidative” and “reductive” stages have been revealed to increase the final testosterone yield. Glucose supplement and microaerophilic conditions during the “reductive” mode ensured increased testosterone production by mycolicibacteria cells. Both strains effectively produced testosterone from phytosterol, but highest ever reported testosterone yield was achieved using M. neoaurum VKM Ac-1815D: 4.59 g/l testosterone was reached from 10 g/l phytosterol thus corresponding to the molar yield of over 66%. The results contribute to the knowledge on phytosterol bioconversion by mycolicibacteria, and are of significance for one-pot testosterone bioproduction from phytosterol bypassing the intermediate isolation of the 17-ketoandrostanes. Graphical Abstract

Introduction. Major projects in the oil refining industry require the involvement of contractors. Cooperation with qualified and responsible contractors can be considered as a competitive advantage, allowing timely delivery of objects with the proper level of quality and safety.Significant injury rates in contracting organizations operating at oil refining facilities attract attention. This leads to an interest in safety of working conditions in the industry. One of the approaches to solving the problem is to use the occupational health and safety management system in the interactions of the customer and the contractor.Problem Statement. The objective of this study is to improve the mechanism of rating contractors from the point of view of occupational and industrial safety.Theoretical Part. The paper uses the official statistical reports on injuries and the data on injuries of employees of contracting organizations at an oil refinery of a large Russian company. A mechanism for rating contractors in this area has been developed. It includes three sections with their own criteria and weight coefficients. The automatically generated and periodically updated rating is proposed to be placed in open access on the website of the Federal Service for Labor and Employment.Conclusions. The use of the proposed rating will allow customers working in the field of oil refining to reasonably judge the risks generated by the industrial safety system of potential contractors.

The hydrodynamics of plasma formed in the interaction of 100 ns UV KrF laser pulses with foam targets with volume densities from 5 to 500 mg/cm3 was studied. Initial and dynamic transmittance at 248 nm wavelength were measured. At intensities of about 1012 W/cm2, the propagation rates of radiation through foam targets reached 80 km/s, while plasma stream velocities from both the front and rear sides of targets were approximately the same, ~ 75 km/s, which confirms a volumetric absorption of radiation within the target thickness and the explosive nature of the plasma formation and expansion.

Abstract A comprehensive set of azimuthal single-spin and double-spin asymmetries in semi-inclusive leptoproduction of pions, charged kaons, protons, and antiprotons from transversely polarized protons is presented. These asymmetries include the previously published HERMES results on Collins and Sivers asymmetries, the analysis of which has been extended to include protons and antiprotons and also to an extraction in a three-dimensional kinematic binning and enlarged phase space. They are complemented by corresponding results for the remaining four single-spin and four double-spin asymmetries allowed in the one-photon-exchange approximation of the semi-inclusive deep-inelastic scattering process for target-polarization orientation perpendicular to the direction of the incoming lepton beam. Among those results, significant non-vanishing cos (ϕ−ϕ S ) modulations provide evidence for a sizable worm-gear (II) distribution, g 1 T q x p T 2 $$ {g}_{1\mathrm{T}}^q\left(x,{\mathrm{p}}_T^2\right) $$ . Most of the other modulations are found to be consistent with zero with the notable exception of large sin (ϕ S ) modulations for charged pions and K +.

A new insight into capillary channel formation with a high aspect ratio in the translucent matter by nanosecond UV laser pulses is discussed based on our experiments on KrF laser multi-pulse drilling of polymethyl methacrylate and K8 silica glass. The proposed mechanism includes self-consistent laser beam filamentation along a small UV light penetration depth caused by a local refraction index increase due to material densification by both UV and ablation pressure, followed by filamentation-assisted ablation. A similar mechanism was shown to be realized in highly transparent media, i.e., KU-1 glass with a multiphoton absorption switched on instead of linear absorption. Waveguide laser beam propagation in long capillary channels was considered for direct electron acceleration by high-power laser pulses and nonlinear compression of excimer laser pulses into the picosecond range.

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Chronic kidney disease is a common medical problem. It is characterized by a peculiar course leading to renal osteodystrophy resulting in increased risk of fractures and joint lesions with the concomitant need for major joints arthroplasty. Moreover, a wide spectrum of organ and metabolic deteriorations due to renal insufficiency causes a more complicated postoperative period with higher mortality and frequent infectious, cardiovascular, hemorrhagic, thrombotic and surgical complications. The highest risks are noted in patients on long lasting hemodialysis.To improve the arthroplasty outcomes an adequate correction of anemia, bone-mineral and electrolyte disorders, arterial hypertension and optimization of dialytic modalities must be ensured.

The influence of epoxy active diluents, 1,4-butanediol diglycidyl ether (BD) and furfuryl glycidyl ether (FUR), in the mixtures with benzoxazine monomer based on bisphenol A, formaldehyde and m-toluidine (BA-mt), on the properties of a matrix was disclosed in this work. Resins were modified to achieve good tackiness at room temperature and reduced viscosity. The influence of mono- and difunctional modifiers on the process of curing was studied by way of differential scanning calorimetry and oscillatory rheology. The addition of BD and FUR shifted the curing peak to higher temperatures and significantly reduced viscosity. Preferable tackiness at ambient temperature was achieved with 10 phr of epoxy components in mixtures. However, cured blends with difunctional epoxy BD had an advantage over monofunctional FUR in enhanced tensile strength with remaining glass transition temperature at the level of neat benzoxazine (217 °C).

It was previously shown that polycaprolactone (PCL)-based electrospun-produced paclitaxel (PTX)-enriched matrices exhibit long-term drug release kinetics and can be used as coatings for drug-eluting stents (DES). The installation of vascular stents involves a twofold increase in stent diameter and, therefore, an elongation of the matrices covering the stents, as well as the arterial wall in a stented area. We studied the influence of matrix elongation on its structure and PTX release using three different electrospun-produced matrices. The data obtained demonstrate that matrix elongation during stent installation does not lead to fiber breaks and does not interfere with the kinetics of PTX release. To study PTX diffusion through the expanded artery wall, stents coated with 5%PCL/10%HSA/3%DMSO/PTX and containing tritium-labeled PTX were installed into the freshly obtained iliac artery of a rabbit. The PTX passing through the artery wall was quantified using a scintillator β-counter. The artery retained the PTX and decreased its release from the coating. The retention of PTX by the arterial wall was more efficient when incubated in blood plasma in comparison with PBS. The retention/accumulation of PTX by the arterial wall provides a prolonged drug release and allows for the reduction in the dose of the drugs in electrospun-produced stent coatings.

To reveal the effect of chlorine substituents in the ring of aromatic amine on the synthesis process of benzoxazine monomer and on its polymerization ability, as well as to develop a fire-resistant material, a previously unreported benzoxazine monomer based on 3,3′-dichloro-4,4′-diaminodiphenylmethane was obtained in toluene and mixture toluene/isopropanol. The resulting benzoxazine monomers were thermally cured for 2 h at 180 °C, 4 h at 200 °C, 2 h at 220 °C. A comparison between the rheological, thermal and fire-resistant properties of the benzoxazines based on 3,3′-dichloro-4,4′-diaminodiphenylmethane and, for reference, 4,4′-diaminodimethylmethane was made. The effect of the reaction medium on the structure of the oligomeric fraction and the overall yield of the main product were studied and the toluene/ethanol mixture was found to provide the best conditions; however, in contrast to most known diamine-based benzoxazines, synthesis in the pure toluene is also possible. The synthesized monomers can be used as thermo- and fire-resistant binders for polymer composite materials, as well as hardeners for epoxy resins. Chlorine-containing polybenzoxazines require more severe conditions for polymerization but have better fire resistance.

We develop theoretical background for the new nonlinear optical phenomenon of narrowly directed monochromatic IR conical emission which has been recently observed when 248-nm UV filaments propagate in xenon (V. D. Zvorykin, et al., Laser Phys. Lett. 13, 125404 (2016)). We treat it as coherent stimulated four-wave mixing process in which two pump KrF laser photons are converted into the coupled pair of resonance IR(828 nm) and VUV (147 nm) photons through 5p5(2P3/2)6p[1/2]0→5p5(2P3/2)6s[3/2]1o and 5p5(2P3/2)6s[3/2]1o→1S0 transitions. We explore the coherent interaction regime which proceeds at a time scale shorter than transverse relaxation time T2. The momentum and energy conservation laws determine the characteristic angle of conical emission. We find that the threshold of this coherent process is determined by the KrF laser pump pulse area.

A novel type of phosphazene containing an additive that acts both as a catalyst and as a flame retardant for benzoxazine binders is presented in this study. The synthesis of a derivative of hexachlorocyclotriphosphazene (HCP) and meta-toluidine was carried out in the medium of the latter, which made it possible to achieve the complete substitution of chlorine atoms in the initial HCP. Thermal and flammability characteristics of modified compositions were investigated. The modifier catalyzes the process of curing and shifts the beginning of reaction from 222.0 °C for pure benzoxazine to 205.9 °C for composition with 10 phr of modifier. The additive decreases the glass transition temperature of compositions. Achievement of the highest category of flame resistance (V-0 in accordance with UL-94) is ensured both by increasing the content of phenyl residues in the composition and by the synergistic effect of phosphorus and nitrogen. A brief study of the curing kinetics disclosed the complex nature of the reaction. An accurate two-step model is obtained using the extended Prout–Tompkins equation for both steps.

The influence of epoxycyclophosphazene modifier on the process of epoxy-amine curing was studied by differential scanning calorimetry (DSC). The study revealed that the curing process of epoxyphosphazene binders with 4′4′diaminodiphenylsulfone (DDS) provides more complete curing of the formulations in comparison with ones applying low molecular-weight polyamide curing agent (L-20). The isothermal kinetics of curing was described by means of model fitting and the isoconversional approach (Friedman method). Accurate n-order approximation was obtained for all systems under study. In particular, the 2-order equation fits well with the main part of curing excluding high degrees of conversion. The process of curing could be distinguished into three zones. The transition from zone 2 to zone 3 correlates with gelation. According to the isoconversional analysis by Friedman method, the diffusion-controlled mechanism is found at final stage of curing.