21 results on '"A. V. Prosvetov"'
Search Results
2. Investigation of the thiol-disulfide system state of rats with encephalopathy caused by the effect of antituberculous drugs
- Author
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A. V. Levich, N. O. Skorokhodova, D. H. Zhyvytsia, and Yu. V. Prosvetov
- Subjects
resistance tuberculosis ,anti-tuberculosis drugs ,adverse drug reactions ,neurotoxicity ,glutathione ,Pathology ,RB1-214 - Abstract
Objective. To determine in an experimental study the nature of changes in the status of the thiol-disulfide system of rats with encephalopathy, due to the influence of complex of anti-tuberculosis drugs for the treatment of chemoresistant tuberculosis and the possibility of their drug correction with the use of ademetionine 1,4-butanedisulfonate. Materials and methods. The study was conducted on 30 Wistar rats, which were divided into 3 groups: 10 – intact group, 10 – control group (treated with antituberculosis drugs) and 10 – main group (treated with antituberculosis drugs and ademetionine as means of correcting toxic effects). The state of the glutathione system and the content of homocysteine and nitrotyrosine were investigated. Results. Experimental therapy with ademetionine in rats treated with antituberculosis drugs helps to reduce the intensity of chronic oxidative stress in nerve tissue. The introduction of ademetionine establishes the most optimal ratio between the levels of reduced and oxidized thiol groups, as well as glutathione, which indicates the active mobilization of the thiol-disulfide system and the neutralization of products of free-radical oxidation. Under the conditions of nitrosative and oxidative stress, the studied agents increase the resistance of nervous tissue to the manifestations of intoxication. Thus, one of the links of the neuroprotective effect of ademetionin was its ability to stabilize the thiol-disulfide equilibrium. Conclusions. In the functioning of the glutathione-dependent enzymatic system in the tissues of the brain of rats treated with anti-tuberculosis drugs, there was decreased activity of glutathione s-transferase, glutathione peroxidase and glutathione reductase by 2.0, 1.7 and 2.4 times, respectively. Under the conditions of ademetionin therapy, there was increase by 1.7 times in the reduced intermediates of the thiol-disulfide system – SH-group, and an increase of the level of reduced glutathione by 1.9 times, against the background of a significant decrease in the content of its oxidized form – 1.4 times. The use of ademetionin also led to a decrease of the content of potentially neurotoxic compounds - nitrotyrosine and homocysteine by 1.4 and 1.5 times, respectively in the brain tissues, which increases the resistance of nervous tissue to the effects of intoxication.
- Published
- 2019
- Full Text
- View/download PDF
3. Diagnostic difficulties in tuberculosis hospital at the bacterial excretion absence
- Author
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А. Yu. Gusarova, Yu. V. Prosvetov, and О. A. Kovalenko
- Subjects
tuberculosis ,cancer ,diagnostics ,Medicine - Abstract
A clinical case of conducting a diagnostic searching a patient with suspected recurrence of pulmonary tuberculosis in the absence of bacterial excretion is presented in the article.
- Published
- 2019
- Full Text
- View/download PDF
4. Unknown Siberian Poems by Vasily Yan
- Author
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Moscow As Rus Media and I. V. Prosvetov
- Subjects
Literature ,business.industry ,media_common.quotation_subject ,Art ,business ,media_common - Abstract
The first publication of poems by the Soviet writer-historian, 1st degree Stalin Prize laureate Vasily Yan (Yanchevetsky), composed in 1920–1923, when he lived and worked in Siberia. Source – handwritten miscellany “Poems of Wanderings”, recently discovered in the Yanchevetskys’ family archive. The publication is accompanied by detailed biographical comments. In the civil war, V. Yanchevetsky took part on the side of the whites as one of the main propagandists of the Kolchak army – the head of the Informative Department of the Special Chancellery of the Supreme Commander’s Staff, editor of the front newspaper “Vperyod”. After the collapse of the white movement, V. Yanchevetsky had to hide his past, changing occupations and places of residence (Achinsk, Uyuk, Minusinsk). The Siberian po- etic cycle, created at this time, makes it possible to understand not only the mood of the author in the last years of the turning point in Russian history, but also literary searches, and the atmosphere of the time in general. The main themes are homeland, revolution, freedom, atheism, building a new life, preserving the personality in the face of political upheavals. Obviously, the influence on the poetic style of the author of such trends as symbolism and futurism, which he was interested in. In Omsk V. Yanchevetsky closely communicated with the writer, poet and avant-garde artist Anton Sorokin, attended his literary evenings at home. Probably, as a result, some of the Siberian poems were written in free verse, to which V. Yanchevetsky had never used before.
- Published
- 2021
- Full Text
- View/download PDF
5. ASTHMA AND TOBACCO SMOKING: DIFFICULTIES OF TREATMENT AND PROSPECTS FOR SOLVING THE PROBLEM
- Author
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S. S. Barinov, Y. V. Prosvetov, O. V. Yatsenko, and S. S. Boev
- Subjects
medicine.medical_specialty ,business.industry ,Family medicine ,medicine ,medicine.disease ,business ,Asthma - Published
- 2019
- Full Text
- View/download PDF
6. Morphology of the Light Curves for the X-ray Novae H1743-322 and GX339-4 during their Outbursts in 2005-2019
- Author
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Ilya A. Mereminskiy, Yu. A. Dvorkovich, A. V. Prosvetov, A. S. Grebenev, V. S. Knyazeva, S. A. Grebenev, and K. D. Ostashenko
- Subjects
Physics ,High Energy Astrophysical Phenomena (astro-ph.HE) ,Morphology (linguistics) ,010308 nuclear & particles physics ,Astrophysics::High Energy Astrophysical Phenomena ,X-ray ,FOS: Physical sciences ,Astronomy and Astrophysics ,Astrophysics ,Light curve ,01 natural sciences ,Accretion disc ,Space and Planetary Science ,0103 physical sciences ,Astrophysics::Solar and Stellar Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena ,010303 astronomy & astrophysics - Abstract
Based on long-term SWIFT, RXTE, and MAXI observations of the X-ray novae H1743-322 (IGR J17464-3213) and GX339-4, we have investigated the morphology and classified the light curves of their X-ray outbursts. In particular, we have confirmed the existence of two radically different types of outbursts, soft (S) and hard (H), in both sources and revealed their varieties, ultrabright (U) and intermediate (I). The properties and origin of the differences in the light curves of these outbursts are discussed in terms of the truncated accretion disk model., 19 pages, 14 figures, 2 tables
- Published
- 2020
7. Investigation of the thiol-disulfide system state of rats with encephalopathy caused by the effect of antituberculous drugs
- Author
-
Yu. V. Prosvetov, N. O. Skorokhodova, A. V. Levich, and D. H. Zhyvytsia
- Subjects
chemistry.chemical_classification ,adverse drug reactions ,Homocysteine ,Chemistry ,resistance tuberculosis ,Nitrotyrosine ,Glutathione peroxidase ,Nervous tissue ,Glutathione reductase ,Glutathione ,Pharmacology ,medicine.disease_cause ,food.food ,chemistry.chemical_compound ,food ,medicine.anatomical_structure ,anti-tuberculosis drugs ,neurotoxicity ,lcsh:Pathology ,medicine ,glutathione ,Ademetionine ,Oxidative stress ,lcsh:RB1-214 - Abstract
Objective. To determine in an experimental study the nature of changes in the status of the thiol-disulfide system of rats with encephalopathy, due to the influence of complex of anti-tuberculosis drugs for the treatment of chemoresistant tuberculosis and the possibility of their drug correction with the use of ademetionine 1,4-butanedisulfonate. Materials and methods. The study was conducted on 30 Wistar rats, which were divided into 3 groups: 10 – intact group, 10 – control group (treated with antituberculosis drugs) and 10 – main group (treated with antituberculosis drugs and ademetionine as means of correcting toxic effects). The state of the glutathione system and the content of homocysteine and nitrotyrosine were investigated. Results. Experimental therapy with ademetionine in rats treated with antituberculosis drugs helps to reduce the intensity of chronic oxidative stress in nerve tissue. The introduction of ademetionine establishes the most optimal ratio between the levels of reduced and oxidized thiol groups, as well as glutathione, which indicates the active mobilization of the thiol-disulfide system and the neutralization of products of free-radical oxidation. Under the conditions of nitrosative and oxidative stress, the studied agents increase the resistance of nervous tissue to the manifestations of intoxication. Thus, one of the links of the neuroprotective effect of ademetionin was its ability to stabilize the thiol-disulfide equilibrium. Conclusions. In the functioning of the glutathione-dependent enzymatic system in the tissues of the brain of rats treated with anti-tuberculosis drugs, there was decreased activity of glutathione s-transferase, glutathione peroxidase and glutathione reductase by 2.0, 1.7 and 2.4 times, respectively. Under the conditions of ademetionin therapy, there was increase by 1.7 times in the reduced intermediates of the thiol-disulfide system – SH-group, and an increase of the level of reduced glutathione by 1.9 times, against the background of a significant decrease in the content of its oxidized form – 1.4 times. The use of ademetionin also led to a decrease of the content of potentially neurotoxic compounds - nitrotyrosine and homocysteine by 1.4 and 1.5 times, respectively in the brain tissues, which increases the resistance of nervous tissue to the effects of intoxication.
- Published
- 2019
- Full Text
- View/download PDF
8. Nocturnal Lights: object-oriented catalog of the nighttime Earth light sources
- Author
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Alexey Poyda, Artem V. Prosvetov, Mikhail Zhizhin, Grigory M. Trifonov, and Alexandr A. Andreev
- Subjects
Object-oriented programming ,Computer science ,Multispectral image ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,0211 other engineering and technologies ,Infrared spectroscopy ,02 engineering and technology ,0202 electrical engineering, electronic engineering, information engineering ,Radiance ,General Earth and Planetary Sciences ,020201 artificial intelligence & image processing ,021101 geological & geomatics engineering ,General Environmental Science ,Remote sensing - Abstract
Various technogenic and natural objects and events produce enough radiance in the visible and infrared spectra to be observable from space. This paper presents a system aiming to become a near-real time catalog of such objects and events. The system is using publicly available VIIRS multispectral sensor nighttime imagery data provided by Suomi-NPP and NOAA-20 satellites. The described system gathers multiple imagery processing algorithms providing the means to extend the algorithm collection and organize it’s execution on both receiving stations and computational clusters.
- Published
- 2018
- Full Text
- View/download PDF
9. Type I X-ray Bursts Detected by the JEM-X Telescope Onboard the INTEGRAL Observatory in 2003–2015
- Author
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I. V. Chelovekov, A. V. Prosvetov, S. A. Grebenev, and Ilya A. Mereminskiy
- Subjects
Physics ,education.field_of_study ,010308 nuclear & particles physics ,Astrophysics::High Energy Astrophysical Phenomena ,Population ,X-ray ,Astronomy and Astrophysics ,Astrophysics ,Light curve ,01 natural sciences ,Luminosity ,law.invention ,Telescope ,Accretion rate ,Neutron star ,Space and Planetary Science ,Observatory ,law ,0103 physical sciences ,education ,010303 astronomy & astrophysics - Abstract
We present the results of our analysis of the JEM-X/INTEGRAL data obtained from January 2003 to January 2015 aimed at searching for type I X-ray bursts from known and new bursters. Such bursts are caused by thermonuclear explosions on the surface of a neutron star. We have searched for bursts in the records of the count rate of the JEM-X detectors in the 3–20 keV energy band. We have separately reconstructed and analyzed the light curves of 104 X-ray bursters known to date based on the JEM-X data. A similar search for bursts was previously carried out in the 15–25 keV data from the IBIS/ISGRI telescope onboard the INTEGRAL observatory obtained in 2003–2009. We have continued to analyze the data from this telescope up until the observations in January 2015. The joint catalog of bursts detected by the two instruments includes 2201 events; their basic parameters are given. The large size of the sample of bursts makes it one of the most representative of the existing one and allows various statistical studies of bursts to be performed. In particular, we have constructed the dependence of the mean rate of type I bursts from bursters on the luminosity (accretion rate), revealed an appreciable burst rate from sources with a near-Eddington luminosity, and investigated the population of multiple bursts with a recurrence time much shorter than the time it takes for a critical mass of matter required for the initiation of an explosion to be accumulated on the neutron star surface. Almost all of the detected bursts are associated with already known bursters,we have found only one previously unknown burster, IGRJ17380-3749, in the archival data, and one more known, but poorly studied source, AX J1754.2-2754, has been identified as a burster. Several similar sources have previously been identified as bursters directly during the INTEGRAL observations.
- Published
- 2017
- Full Text
- View/download PDF
10. X-ray nova MAXI J1828-249. Evolution of the broadband spectrum during its 2013–2014 outburst
- Author
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A. V. Prosvetov, S. A. Grebenev, A. Mescheryakov, Roman Krivonos, and R. A. Burenin
- Subjects
High Energy Astrophysical Phenomena (astro-ph.HE) ,Physics ,Infrared ,Astrophysics::High Energy Astrophysical Phenomena ,FOS: Physical sciences ,Synchrotron radiation ,Astronomy and Astrophysics ,Nova (laser) ,Astrophysics ,Radiation ,01 natural sciences ,law.invention ,Telescope ,Corona (optical phenomenon) ,Astrophysical jet ,Space and Planetary Science ,law ,0103 physical sciences ,Black-body radiation ,Astrophysics::Earth and Planetary Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena ,010306 general physics ,010303 astronomy & astrophysics ,Astrophysics::Galaxy Astrophysics - Abstract
Based on data from the SWIFT, INTEGRAL, MAXI/ISS orbital observatories, and the ground-based RTT-150 telescope, we have investigated the broadband (from the optical to the hard X-ray bands) spectrum of the X-ray nova MAXI J1828-249 and its evolution during the outburst of the source in 2013-2014. The optical and infrared emissions from the nova are shown to be largely determined by the extension of the power-law component responsible for the hard X-ray emission. The contribution from the outer cold regions of the accretion disk, even if the X-ray heating of its surface is taken into account, turns out to be moderate during the source's "high" state (when a soft blackbody emission component is observed in the X-ray spectrum) and is virtually absent during its "low" ("hard") state. This result suggests that much of the optical and infrared emissions from such systems originates in the same region of main energy release where their hard X-ray emission is formed. This can be the Compton or synchro-Compton radiation from a high-temperature plasma in the central accretion disk region puffed up by instabilities, the synchrotron radiation from a hot corona above the disk, or the synchrotron radiation from its relativistic jets., 18 pages, 8 figures
- Published
- 2016
- Full Text
- View/download PDF
11. Low-Frequency Quasi-Periodic Oscillations in the X-ray Nova MAXI J1535-571 at the Initial Stage of Its 2017 Outburst
- Author
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Andrey Semena, S. A. Grebenev, A. V. Prosvetov, and I. A. Mereminskiy
- Subjects
Physics ,High Energy Astrophysical Phenomena (astro-ph.HE) ,Emission flux ,010308 nuclear & particles physics ,Infrasound ,Astrophysics::High Energy Astrophysical Phenomena ,X-ray ,Spectral density ,FOS: Physical sciences ,Astronomy and Astrophysics ,Astrophysics ,Nova (laser) ,Low frequency ,01 natural sciences ,Space and Planetary Science ,0103 physical sciences ,Stage (hydrology) ,Quasi periodic ,Astrophysics - High Energy Astrophysical Phenomena ,010303 astronomy & astrophysics - Abstract
We report the discovery of low-frequency quasi-periodic oscillations (QPOs) in the power spectrum of the X-ray nova MAXI J1535-571 at the initial stage of its outburst in September 2017. Based on data from the SWIFT and INTEGRAL instruments, we have traced the evolution of the QPO parameters (primarily their frequency) with time and their correlation with changes in the X-ray spectrum of the source (changes in the emission flux and hardness). We place constraints on the theoretical QPO generation models., 12 pages, 7 figures
- Published
- 2018
12. QPO and LFN in the power spectrum of rapid variability for the X-ray nova SWIFT J174510.8-262411
- Author
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A. V. Prosvetov and S. A. Grebenev
- Subjects
Physics ,Oscillation ,Astrophysics::High Energy Astrophysical Phenomena ,Spectral density ,Astronomy ,Astronomy and Astrophysics ,Astrophysics ,Radius ,Nova (laser) ,Light curve ,Black hole ,Amplitude ,Space and Planetary Science ,Noise (radio) - Abstract
Results of the study of the X-ray nova SWIFT J174510.8-262411 by the INTEGRAL, SWIFT, and VLA observatories in September–October 2012 at the early outburst phase are presented. Attention is focused on analyzing the power spectrum of X-ray flux fluctuations of the source in which a powerful quasi-periodic oscillation (QPO) peak has been detected. The evolution of the QPO peak parameters with time has been traced; a correlation between the QPO frequency, low-frequency noise (LFN) parameters, X-ray and radio fluxes, and fractional polarization of radio emission has been revealed. The fractal properties of the source’s light curves in the standard X-ray band (
- Published
- 2015
- Full Text
- View/download PDF
13. Fractal analysis of light curves for the microquasar GX 339-4
- Author
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S. A. Grebenev and A. V. Prosvetov
- Subjects
Physics ,Accretion (meteorology) ,Astrophysics::High Energy Astrophysical Phenomena ,Binary number ,Astronomy and Astrophysics ,Function (mathematics) ,Astrophysics ,Light curve ,Fractal analysis ,Fractal dimension ,symbols.namesake ,Accretion disc ,Space and Planetary Science ,Fourier analysis ,symbols ,Astrophysics::Earth and Planetary Astrophysics ,Astrophysics::Galaxy Astrophysics - Abstract
Results of a fractal analysis of the X-ray light curves from accreting black holes in low-mass binary systems are presented for the object GX 339-4 as an example. The fractal dimension of the light curves is shown to be strongly dependent on the presence of quasi-periodic oscillations (QPOs) in the observations. A correlation between the fractal dimension of the light curves and the frequency of the QPO peak has been revealed. A method supplementary to a Fourier analysis that allows the pattern of accretion disk emission as a function of time scales to be investigated is proposed. The results of this analysis can be explained if the accretion disk is separated by the QPO region into two zones with different emission parameters.
- Published
- 2014
- Full Text
- View/download PDF
14. Broadband spectrum of the X-ray nova SWIFT J174510.8-262411 at the decaying phase of its outburst
- Author
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S. A. Grebenev, R. A. Burenin, and A. V. Prosvetov
- Subjects
Physics ,Accretion (meteorology) ,Infrared ,Astrophysics::High Energy Astrophysical Phenomena ,Astronomy ,Flux ,Synchrotron radiation ,Astronomy and Astrophysics ,Nova (laser) ,Astrophysics ,Black hole ,Astrophysical jet ,Space and Planetary Science ,Astrophysics::Solar and Stellar Astrophysics ,Black-body radiation - Abstract
Results of quasi-simultaneous SWIFT and RTT-150 observations for the X-ray nova SWIFT J174510.8-262411 in May–June 2013 at the decaying phase of its outburst are presented. It is shown that the nova spectrum can be fitted in a very wide energy range (from the infrared z and i bands to hard X-rays) by a single power law attenuated due to absorption but without any traces of the presence of a soft (blackbody) component. The presence of such a component is suggested by the generally accepted models of disk accretion onto a black hole in a binary system. The observation of a single power-law spectrum may imply that synchrotron radiation from the source’s relativistic jets makes a major contribution to its flux or that the accretion disk is everywhere hot, optically thin, and radiates nonthermally.
- Published
- 2014
- Full Text
- View/download PDF
15. GAN for Recommendation System
- Author
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A. V. Prosvetov
- Subjects
History ,Artificial neural network ,business.industry ,Computer science ,Recommender system ,Machine learning ,computer.software_genre ,Field (computer science) ,Computer Science Applications ,Education ,Adversarial system ,Work (electrical) ,Artificial intelligence ,business ,computer ,High potential ,Generative grammar - Abstract
In our day there are many approaches for recommendation generation, however several unsolved problems still exist. In our work we study the potential of Generative Adversarial Networks to generate relevant recommendations and compare the proposed approach with another recommendations system based on neural networks. We found that recommendation system based on GANs can successively compete with state-of-the-art network in the field of recommendation generation and suggest, that GAN recommendation system have high potential.
- Published
- 2019
- Full Text
- View/download PDF
16. Second outburst of the black hole candidate MAXI J1836-194 from SWIFT and INTEGRAL observations
- Author
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A. V. Prosvetov, S. A. Grebenev, and R. A. Sunyaev
- Subjects
Physics ,Swift ,Jet (fluid) ,Range (particle radiation) ,Astrophysics::High Energy Astrophysical Phenomena ,Astronomy ,Astronomy and Astrophysics ,Astrophysics ,Black hole ,Accretion disc ,Space and Planetary Science ,Black-body radiation ,Binary system ,Optical emission spectroscopy ,computer ,computer.programming_language - Abstract
Details of the observations of a new (second) outburst of the X-ray transientMAXI J1836-194 discovered late in August 2011, a suspected black hole in a low-mass binary system, with the instruments of the SWIFT and INTEGRAL orbiting observatories are presented. The outburst was weaker than the first one; the source had a power-law spectrum in a wide X-ray (0.3–400 keV) energy range without any clear evidence for the presence of a soft (blackbody) component related to the emission from the outer accretion disk regions. This shows that the outburst was a “failed” one: the source did not pass through the sequence of spectral states characteristic of X-ray novae. The observed optical emission from the source whose variability was strongly correlated with its X-ray variability seems to have also been an extension of the power-law spectrum. Spectrum uniformity is, on the whole, unusual for other sources containing a black hole and raises the question about the nature of the emission from MAXI J1836-194 (disk or jet).
- Published
- 2013
- Full Text
- View/download PDF
17. [A decline in the efficacy of hyposensitization due to the adverse effects of antitubercular agents against a background of immuno-correction]
- Author
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Iu V, Prosvetov, O G, Spesivtsev, and L D, Gal'chanskaia
- Subjects
Adult ,Male ,Adjuvants, Immunologic ,Desensitization, Immunologic ,Antitubercular Agents ,Humans ,Female ,Middle Aged ,Tuberculosis, Pulmonary - Published
- 1990
18. Investigation of the evaporation process and sonic limits in sodium heat pipes
- Author
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V. P. Sorokin, B. A. Chulkov, I. V. Yagodkin, M. N. Ivanovskii, and V. V. Prosvetov
- Subjects
Materials science ,Critical heat flux ,Mechanical Engineering ,General Chemical Engineering ,education ,General Engineering ,Thermodynamics ,Condensed Matter Physics ,Heat pipe ,Heat flux ,Heat spreader ,Heat transfer ,Micro-loop heat pipe ,Micro heat exchanger ,Composite material ,Copper in heat exchangers - Abstract
The maximum heat fluxes in the heating zone and the sonic limits of power transfer in sodium heat pipes and vapor chambers with composite (channel) wicks are investigated experimentally.
- Published
- 1977
- Full Text
- View/download PDF
19. [Excretion of catecholamines and DOPA in the urine of patients with pulmonary tuberculosis during chemotherapy]
- Author
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Iu V, Prosvetov
- Subjects
Adult ,Male ,Norepinephrine ,Catecholamines ,Epinephrine ,Dopamine ,Antitubercular Agents ,Humans ,Female ,Drug Tolerance ,Middle Aged ,Tuberculosis, Pulmonary ,Dihydroxyphenylalanine - Abstract
The results of the study on urine excretion of catecholamines such as adrenaline, noradrenaline, dopamine and their precursor DOPA in 59 patients with active tuberculosis of the lung and varying tolerance of the chemotherapeutics are presented. After adverse reactions have developed to the drugs, there are changes in monoamine excretion, which remained for long periods after elimination of clinical signs of intoxication. The changes were indicative of overstrain of the sympathetic-adrenal system which might be the cause of drug intolerance relapsing after a new start of the chemotherapy. Such patients should be registered in risk groups. They require long-term nonspecific hyposensitization.
- Published
- 1989
20. [Use of splenin in the combined treatment of pulmonary tuberculosis patients]
- Author
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O G, Spesivtsev, L D, Gal'chanskaia, L I, Sobolevskaia, and Iu V, Prosvetov
- Subjects
Adult ,Male ,Thymus Hormones ,Adjuvants, Immunologic ,Antitubercular Agents ,Drug Evaluation ,Humans ,Thymopoietins ,Drug Therapy, Combination ,Female ,Middle Aged ,Tuberculosis, Pulmonary ,Spleen - Published
- 1985
21. The comparison of autoencoder architectures in improving of prediction models.
- Author
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A. V. Prosvetov
- Published
- 2018
- Full Text
- View/download PDF
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