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English language teaching in Indonesia continues to improve the communicative ability of students. To support English language mastery, school subjects such as mathematics, science, and technology are taught in English. However, the main problem faced by prospective science teachers is their limited English proficiency which leads to limited English communication. Therefore, a tool called "Science Instruction in English Audiobook" was seen as one of the media which can help prospective science teachers to practice the teaching skills in English. Hence, this study aims to develop and evaluate a "Science Instruction in English Audiobook" to help prospective science teachers improve their science teaching skills in English. The skills of science teaching in English were then observed to find out the effectiveness of the audiobook. The subjects were 65 prospective science teachers. The research design was Research and Development consisting of problem analysis, literature study, product design, product validation, revision, trial, revision, application, and revision. The "Science Instruction in English Audiobook" product has been successfully developed. The product is a sound recording in .mp3 format with a duration of almost 1 hour 3 minutes 43 seconds. The audiobook contains science vocabulary material (physics, chemistry, and biology) and teaching skills in English. Following the research design steps, the product has been validated by material, media, and language experts. Based on the validation from the experts, it can be stated that the audiobook product is valid with an accumulated percentage of 98% which means it is feasible to be used as a learning resource to develop the English skills of prospective science teachers. Moreover, it has been found that audiobooks can help prospective science teachers to practice effective science teaching skills in English.

AbstractChronic pain affects more than 50 million Americans. Treatments remain inadequate, in large part, because the pathophysiological mechanisms underlying the development of chronic pain remain poorly understood. Pain biomarkers could potentially identify and measure biological pathways and phenotypical expressions that are altered by pain, provide insight into biological treatment targets, and help identify at-risk patients who might benefit from early intervention. Biomarkers are used to diagnose, track, and treat other diseases, but no validated clinical biomarkers exist yet for chronic pain. To address this problem, the National Institutes of Health Common Fund launched the Acute to Chronic Pain Signatures (A2CPS) program to evaluate candidate biomarkers, develop them into biosignatures, and discover novel biomarkers for chronification of pain after surgery. This article discusses candidate biomarkers identified by A2CPS for evaluation, including genomic, proteomic, metabolomic, lipidomic, neuroimaging, psychophysical, psychological, and behavioral measures. Acute to Chronic Pain Signatures will provide the most comprehensive investigation of biomarkers for the transition to chronic postsurgical pain undertaken to date. Data and analytic resources generatedby A2CPS will be shared with the scientific community in hopes that other investigators will extract valuable insights beyond A2CPS's initial findings. This article will review the identified biomarkers and rationale for including them, the current state of the science on biomarkers of the transition from acute to chronic pain, gaps in the literature, and how A2CPS will address these gaps.

The aim of this study was to evaluate the influence of different pressures of homogenization on whole milk powder with crystallized lactose on free fat content and particle size. Three homogenization pressure levels were applied. The powder produced at homogenization pressure of 75/5 MPa presented a smaller number of particles in the region < 1 μm (39.28%) and higher free fat content (13.78%) when compared to the powder produced at conventional homogenization pressure (15/5 MPa), which presented 59.40% particles in the region < 1 μm and 5.03% of free fat. Milk powder produced at 0/0 MPa presented the lowest number of particles in the region < 1 μm (24.60%) and the highest free fat content (19.39%). This study showed that the powder produced at a homogenization pressure of 15/5 MPa, which is commonly used in the industry, produces a crystallized milk powder with less suitable properties than the one obtained without homogenization.

EVALUATION AND COMPARISON OF COLOIDAL SYSTEMS OF UHT MILK MARKETED IN THE SOUTH AND SOUTHEAST REGIONS OF BRAZIL. Ultra high temperature (UHT) milk has great relevance in the Brazilian dairy market. Thermal processing, physical-chemical and compositional properties have relevant impact on the quality of milk processed via UHT. The emergence of new categories of this product makes the production scenario even more challenging. The aim of this study was to investigate UHT milk and the effect of food additives on it, from a colloidal perspective, in the main consumer regions. The colloidal systems of samples with or without addition of stabilizers and with or without addition of tricalcium phosphate were evaluated based on analyses of ionic calcium concentration, pH, sedimentation, HCT (heat coagulation time), ethanol stability, particle size (D90) and zeta potential. The results indicated a relevant colloidal stability for this type of matrix, in addition to an efficient industrial homogenization process. The samples that received stabilizers addition showed lower ionic calcium, higher HCT and greater ethanol stability. There was no significant difference in sediment mass and pH. The samples that received Ca3(PO4)2 addition showed higher sedimentation and lower stability to ethanol. There were no significant differences regarding ionic calcium, pH and HCT.

Colorectal cancer is, and continues to be, one of the most important global health burdens due to its notorious high mortality rate and continuous resilience to traditional modes of treatment, specifically chemotherapeutic agents such as oxaliplatin. The resistance is mediated through specified genes highly involved in survival and resistant mechanisms in cancerous cells, like ABCG2 and UPF1 genes. Given the challenge, this study focuses on the coriander leaf extract as a new strategy for overcoming oxaliplatin resistance in colorectal cancer. In the present study, the authors examined the anticancer activities of the extracts from coriander leaves, which exerted inhibitory activity toward ABCG2 and UPF1 proteins believed to be involved in chemoresistance. Molecular docking analysis was done by PyRx software to evaluate the binding properties of the target genes with the 31 compounds in coriander leaf extract to find the best compound that may give an efficient way of overcoming resistance against oxaliplatin. Out of all the compounds screened, rutin came out to be the potential candidate. The binding affinities were highly impressive, about -8.4 kcal/mol for UPF1 and -7.8 kcal/mol for ABCG2. These values are especially important because they exceed the conventional affinity of known chemotherapy inhibitors, such as Ko143 and actinomycin D, which served as positive controls in this study. The higher binding affinity of rutin indicates that it may potentiate chemotherapy by specifically targeting ABCG2 and UPF1 in colorectal cancer cells. This strategic approach could limit the resistance to oxaliplatin and increase the treatment success rate in colorectal cancer patients. The observations of this work open up new perspectives in the study of natural products as adjuvants or alternatives to traditional chemotherapy that, in the future, could give rise to more efficient and less toxic strategies against colorectal cancer.

Most large carnivores feed on prey infrequently and may expend large amounts of energy to locate, capture and kill their prey. This makes them probabilistically vulnerable to fluctuating rates of energy acquisition over time, especially within the increasingly human-altered landscapes that dominate their remaining range. Consequently, quantifying their hunting behaviors and success rates is critical, yet direct observation of these events is rarely feasible. We theorized that we could determine prey pursuit and capture in African wild dogs (Lycaon pictus) using a mechanistic approach by constructing Boolean algorithms applied to accelerometer data derived from collar-mounted tags. Here, we used this method and then iteratively improved algorithms by testing them on observed hunts and kills of collared packs. Using this approach on 47 days of acceleration from three wild dogs in three packs, we identified 29 hunts with 10 kills, all of which were confirmed by direct observation except for a single kill. Our results demonstrate that hunting effort and success can largely be determined from acceleration data using a mechanistic approach. This is particularly valuable when such behaviors are rarely quantified and offers a template for research on foraging in canid species, while also contributing to the expanding body of literature that employs similar methods to quantify hunting in large carnivores.

Kebugaran Jasmani mengacu pada seberapa baik dan buruknya sesesiswa menjaga kebugaran fisiknya. Ini merupakan ukuran dari kemampuan sesesiswa untuk menjalani aktivitas fisik dengan baik tanpa kesulitan berarti. Tujuan melaksanakan penelitian ini untuk mengetahui tingkat kebugaran jasmani jasmani siswa putra kelas VIII di SMP Negeri 01 Sukadana Kabupaten Kayong Utara. Penelitian ini menggunakan metode deskriptif kuantitatif dengan menggunakan variable tunggal atau jumlah keseluruhan siswa putera kelas VIII yang berjumlah 81 siswa. Hasil penelitian terdapat pengkategorian kebugaran jasmani siswa putera kelas VIII dengan kategori baik sekali 3 siswa (3,7%), kategori Baik 12 siswa (14,8%), kategori Sedang 33 siswa (40,7%), kategori Kurang 28 siswa (34,6%), dan yang kategori Kurang Sekali 5 siswa (6,2%). Setelah pelaksanaan penelitian dapat disimpulkan kebugaran jasmani pada siswa putra kelas VIII di SMP Negeri 1 Sukadana Kabupaten Kayong Utara yang paling banyak adalah kategori Sedang yaitu 40,7% dari total seluruh 81 siswa

Background: Generalized pustular psoriasis (GPP) is a rare skin disease characterized by episodes of widespread sterile pustules. Methods: A retrospective cohort study using data from the US IBM MarketScan Commercial and Optum Clinformatics Data Mart databases between October 1, 2015 and March 31, 2020 was performed to describe adherence and persistence to biologics in patients with GPP. Patients were aged ≥18 years with newly diagnosed GPP (International Classification of Diseases code L40.1) and had ≥1 inpatient or ≥2 outpatient claims. Results: Biologics were dispensed to 110 of 502 (22%) and 73 of 528 (14%) patients from MarketScan and Optum databases, respectively. The mean proportion of days covered (PDC) (range) was similar in both databases (MarketScan, 65% [8%-100%]; Optum, 59% [8%-99%]), and good adherence (≥80% PDC) was uncommon (MarketScan, 36%; Optum, 24%). Mean (standard deviation) persistence was similar in both databases (MarketScan, 287 [122] days; Optum, 261 [134] days). In Optum, the mean PDC was similar between age categories; good adherence was more common in patients aged 18 to 64 years (28%) versus ≥65 years (13%). Mean persistence was longer in patients aged 18 to 64 years (267 days) versus ≥65 years (242 days). Conclusions: Overall, adherence and persistence were generally poor and varied according to the biologic class, database, and age. Improving adherence may help improve GPP treatment outcomes.

STEAM é um acrônimo para Ciências, Tecnologia, Engenharia, Artes e Matemática, promovendo uma aprendizagem significativa e colaborativa. Essa abordagem reconhece a importância da criatividade e inovação no desenvolvimento dos alunos. A Aprendizagem Baseada em Projetos (ABP) é fundamental para o STEAM, pois promove a transdisciplinaridade e conecta conceitos escolares com problemas reais. Projetos STEAM devem ser integrados e contextualizados, evitando a fragmentação do conhecimento e incentivando a investigação, criatividade e pensamento crítico. A formação docente é essencial para a implementação eficaz dessa abordagem, promovendo autonomia e autoria nos professores. Isso é crucial para formar cidadãos mais humanos, socialmente justos e preparados para os desafios. Este artigo relata um exemplo prático de formação promovido pelo Grupo de Pesquisa em Educação, Tecnologias e Cultura Digital (GRUPETeC) em uma escola técnica. Professores de diversas áreas participaram de atividades teóricas e práticas para desenvolver projetos interdisciplinares baseados na abordagem STEAM.

O estudo avaliou a substituição parcial do cimento Portland CP IV – 32 RS por pó de vidro lapidado, com aditivo plastificante, visando reduzir emissões de CO₂ e melhorar a resistência do concreto. Foram testados blocos com 0%, 3%, 5% e 7% de substituição por pó de vidro, apresentando resistências médias de 24,87 MPa, 28,64 MPa, 30,23 MPa e 32,23 MPa, respectivamente. Os resultados indicaram aumentos de resistência de 15%, 21,4% e 29,5% para as substituições de 3%, 5% e 7%, superando as expectativas. Conclui-se que essa substituição é viável e sustentável, melhorando a resistência do concreto e reduzindo seu impacto ambiental.

Background: The actual prognostic impact of prior lupus nephritis (LN) diagnosis on end-stage kidney disease (ESKD) patients remains questionable, especially in relation to outcomes of kidney transplantation (KTx) We aim to determine the survival of the graft and recipient after the KTx procedure among patients with ESKD due to LN in comparison to non-LN. Methods: This meta-analysis included retrospective studies from the last two decades, focusing on the KTx’s outcomes among ESKD due to LN in comparison to non-LN. We establish the graft/recipient survival rate at different follow-up intervals as the primary outcome, and acute graft rejection and pooled graft failure rate as secondary outcomes. All analyses were performed with the random-effect model (REM) and were presented as odd ratio (OR; within 95% confidence interval (CI)). The protocol of this study was registered in PROSPERO: CRD42023394310. Results: A total of 1,299 KTx (368 LN patients) from 10 studies with >10 years of follow-up were thoroughly reviewed. All checkpoints (at 1-, 5-, 10, and 15-year post-KTx) on graft survival rate demonstrated comparable outcomes in either LN or non-LN (e.g., at 10-year follow up (OR, 1.08 [0.40, 2.91]; p = 0.88). Similar findings at all checkpoints for recipient survival rate were also observed without statistically significant difference between LN and non-LN arm (e.g., at 10-year checkpoint; OR, 0.99 [0.68, 1.46]; p = 0.98). Both of our secondary analyses also presented insignificant differences (p = 0.70 and = 0.16, respectively). Conclusions: Our findings suggested that prognosis of ESKD due to complicated LN is equal compared to ESKD associated with non-LN etiologies, suggesting the impact of LN as the inducing cause of ESKD on KTx outcome is relatively neglectable.