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1. A Review of Existing Sources for the Design of an Archaeological Underwater Cultural Heritage Database of Puglia Region (Italy)

Author

A. Spreafico, E. Colucci, F. Chiabrando, and R. Auriemma

Subjects
Technology, Engineering (General). Civil engineering (General), TA1-2040, Applied optics. Photonics, TA1501-1820
Abstract

Underwater cultural heritage (UCH) in Italy is under-documented despite its significance. Creating a comprehensive UCH database is essential but faces challenges, such as complex documentation processes, data interoperability, and international standard adherence. This paper examines data models, standards, and the use of webGIS and databases for underwater cultural heritage documentation in Italy and globally. International documents like the 1996 ICOMOS Charter and the 2001 UNESCO Convention emphasize in-situ preservation. However, documentation efforts remain scattered, lacking a unified database. GIS technologies are vital for managing and analyzing UCH data but are underutilized for public access and tourism. Projects like Andar per Mare and Archim3des in the Puglia region aim to promote underwater cultural heritage using webGIS platforms. However, existing sources like CartaPulia face limitations, including a lack of standardization, specialized fields for underwater cultural heritage characteristics, and language barriers. The proposed solution involves creating a new data model based on standards, resulting in a bilingual geodatabase. This geodatabase will support scientific and tourism-focused webGIS applications, enhancing accessibility and promoting Italy's underwater cultural heritage. A unified database will prevent duplication, facilitate discoveries, and promote Italy's cultural heritage.

Published
2024
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2. An Archival Framework for Sharing of Cultural Heritage 3D Survey Data: OpenHeritage3D.org

Author

S. McAvoy, B. Tanduo, A. Spreafico, F. Chiabrando, D. Rissolo, J. Ristevski, and F. Kuester

Subjects
Technology, Engineering (General). Civil engineering (General), TA1-2040, Applied optics. Photonics, TA1501-1820
Abstract

Photogrammetry and LiDAR have become increasingly accessible methods for documentation of Cultural Heritage sites. Academic and government agencies recognize the utility of high-resolution 3D models supporting long-term asset management through visualization, conservation planning, and change detection. Though detailed models can be created with increasing ease, their potential for future use can be constrained by a lack of accompanying topographic data, data collector skill level, and incomplete recording of the key metadata and paradata which make such survey data useful to future endeavors. In this paper, informed by various international survey organizations and data archives, we present a framework to record and communicate Cultural Heritage - focusing on architectures based on 3D metric survey - to first describe the data and metadata which should be included by surveyors to enable data usage and to communicate the expected utility of this data.

Published
2024
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3. Robotics for Heritage Surveying: preliminary test on Leica BLK ARC & Spot® toward autonomous 3D mapping

Author

G. Sammartano, A. Spreafico, B. Tanduo, and F. Chiabrando

Subjects
Technology, Engineering (General). Civil engineering (General), TA1-2040, Applied optics. Photonics, TA1501-1820
Abstract

Today, robotics technologies are revolutionizing surveying and construction in AEC fields, enhancing precision, safety, and efficiency and also in the realm of Cultural Heritage knowledge and protection, the integration of cutting-edge technologies is reshaping consolidated surveying methods for documentation, especially in risk scenarios. One such innovation making waves is the use of mobile mapping systems, where automation and expediency are the determining factors in technological development, both in the direction of in indoor positioning (visual/LiDAR SLAM, UWB, etc.) and 3D mapping of known and unknown spaces. The BLK ARC by Leica, equipping the Agile Mobile Robot Spot® by Boston Dynamics, as a dynamic sensing platform, is here presented and discussed. BLK ARC is part of a diverse landscape of mobile mapping systems, each offering unique features and specifications tailored to different surveying needs, from handheld devices and wearable systems, to vehicle-mounted systems, the options vary in dimension, weight, price, and technical capabilities and the recent companies and research are largely focusing on them. A preliminary evaluation takes into consideration the dual dynamic-static 3D data-types, considering local and global accuracy of the 3D data delivered from the first experimental tests in a case study. Different metrics have been considered including acquisition time, precision, resolution, density, accuracy, roughness, and completeness of the acquired data.

Published
2024
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4. 3D WEBGIS APPLICATIONS FOR DIGITAL HUMANITIES STUDIES: THE TURIN 1911 PROJECT

Author

A. Spreafico, F. Chiabrando, and C. Della Coletta

Subjects
Technology, Engineering (General). Civil engineering (General), TA1-2040, Applied optics. Photonics, TA1501-1820
Abstract

Documentation of CH is paramount to preserve its memory and allow its study, especially when CH is meant to be dismantled, as for the architectures of World’s Fairs. Very few efforts are undertaken to achieve this goal and national and international institutions rarely adopt innovative digital technologies. Digital technologies and products like 3D digital models are successfully and largely applied in CH domains, while webGIS is less explored for CH. Nevertheless, 3D digital models are rarely adopted to accompany digital archives and Digital Humanities studies. Very few cases use 3D models for World’s Fairs’ study and documentation. WebGIS is not used for World’s Fairs, and are scarcely adopted and not fully exploited by Digital Humanities and digital archives for sharing data and information about CH. Turin 1911 is the first digital project aimed to virtually document, recreate, and study an entire World’s Fair. Combining digital technologies (geo-DB, 3D digital reconstruction, and 3D webGIS) with cataloging standards, Turin 1911 is a pioneering initiative that applies these innovations to Digital Humanities in order to share information online. In this paper, dedicated webGIS applications are developed for the Turin 1911 needs, reporting the designed procedure, challenges in the development phase, and potentialities for Digital Humanities research. Finally, BIM models are also integrated in webGIS apps, making visible no more visible architectures. The paper discusses how webGIS apps could become a way for sharing information and data, but also a working environment for Digital Humanities studies where the research takes place in 3D environments.

Published
2023
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5. Inclusive Electron Scattering in the Resonance Region off a Hydrogen Target with CLAS12

Author

Klimenko, V., Carman, D. S., Gothe, R. W., Joo, K., Markov, N., Mokeev, V. I., Niculescu, G., Achenbach, P., Alvarado, J. S., Armstrong, W., Atac, H., Avakian, H., Baashen, L., Baltzell, N. A., Barion, L., Bashkanov, M., Battaglieri, M., Benmokhtar, F., Bianconi, A., Biselli, A. S., Boiarinov, S., Bossu, F., Brinkmann, K. -Th., Briscoe, W. J., Brooks, W. K., Burkert, V. D., Bueltmann, S., Capobianco, R., Carvajal, J., Celentano, A., Chatagnon, P., Ciullo, G., Angelo, A. D, Dashyan, N., Defurne, M., De Vita, R., Deur, A., Diehl, S., Dilks, C., Djalali, C., Dupre, R., Egiyan, H., Alaoui, A. El, Fassi, L. El, Elouadrhiri, L., Fegan, S., Fernando, I. P., Filippi, A., Gavalian, G., Gilfoyle, G. P., Glazier, D. I., Hafidi, K., Hakobyan, H., Hattawy, M., Hauenstein, F., Hayward, T. B., Heddle, D., Blin, A. N. Hiller, Hobart, A., Holtrop, M., Ilieva, Y., Ireland, D. G., Isupov, E. L., Jiang, H., Jo, H. S., Joosten, S., Kageya, T., Keller, D., Kim, A., Kim, W., Klest, H. T., Kripko, A., Kubarovsky, V., Kuhn, S. E., Lanza, L., Lee, S., Lenisa, P., Livingston, K., MacGregor, I. J. D., Marchand, D., Martiryan, D., Mascagna, V., Matamoris, D., McKinnon, B., Mineeva, T., Mirazita, M., Camacho, C. Munoz, Turonski, P. Nadel, Nagorna, T., Neupane, K., Niccolai, S., Osipenko, M., Paolone, M., Pappalardo, L. L., Paremuzyan, R., Pasyuk, E., Paul, S. J., Phelps, W., Pilleux, N., Rafael, S. Polcher, Price, J. W., Prok, Y., Raue, B. A., Richards, J., Ripani, M., Ritman, J., Rossi, P., Rusova, A. A., Salgado, C., Schadmand, S., Schmidt, A., Sharabian, Y. G., Shirokov, E. V., Shrestha, S., Sparveris, N., Spreafico, M., Stepanyan, S., Strakovsky, I. I., Strauch, S., Tan, J. A, Tenorio, M., Trotta, N., Tyson, R., Ungaro, M., Vallarino, S., Venturelli, L., Vittorini, T., Voskanyan, H., Voutier, E., Watts, D. P., Weerasinghe, U., Wei, X., Wood, M. H., Xu, L., Zachariou, N., Zhao, Z. W., Zurek, M., and Shresth, S.

Subjects
High Energy Physics - Experiment
Abstract

Inclusive electron scattering cross sections off a hydrogen target at a beam energy of 10.6 GeV have been measured with data collected from the CLAS12 spectrometer at Jefferson Laboratory. These first absolute cross sections from CLAS12 cover a wide kinematic area in invariant mass W of the final state hadrons from the pion threshold up to 2.5 GeV for each bin in virtual photon four-momentum transfer squared $Q^2$ from 2.55 to 10.4~GeV$^2$ owing to the large scattering angle acceptance of the CLAS12 detector. Comparison of the cross sections with the resonant contributions computed from the CLAS results on the nucleon resonance electroexcitation amplitudes has demonstrated a promising opportunity to extend the information on their $Q^2$ evolution up to 10 GeV$^2$. Together these results from CLAS and CLAS12 offer good prospects for probing the nucleon parton distributions at large fractional parton momenta $x$ for $W$ < 2.5 GeV, while covering the range of distances where the transition from the strongly coupled to the perturbative regimes is expected.

Published
2025

6. Combinatorial Approach on the Recurrence Sequences: An Evolutionary Historical Discussion about Numerical Sequences and the Notion of the Board

Author

Francisco Regis Vieira Alves, Paula Maria Machado Cruz Catarino, Renata Passos Machado Vieira, and Elen Viviani Pereira Spreafico

Abstract

The tradition of studies involving the combinatorial approach to recurring numerical sequences has accumulated a few decades of tradition, and several problems continue to attract the interest of mathematicians in several countries. This work specifically discusses the Fibonacci, Pell, and Jacobsthal sequences, focusing on Mersenne sequences. The often-used definition of board involves considering how to fill a specific regular surface--the board--with a limited quantity of regularly shaped tiles. On the other hand, an analogous problem can be generalized and exemplifies current research developments. Finally, the examples covered constitute unexpected ways of exploring visualization and other skills in mathematics teachers' learning, consequently inspiring them for their teaching context.

Published
2024

7. THE IPAD PRO BUILT-IN LIDAR SENSOR: 3D RAPID MAPPING TESTS AND QUALITY ASSESSMENT

Author

A. Spreafico, F. Chiabrando, L. Teppati Losè, and F. Giulio Tonolo

Subjects
Technology, Engineering (General). Civil engineering (General), TA1-2040, Applied optics. Photonics, TA1501-1820
Abstract

The main goal of this ongoing research is the evaluation of the iPad Pro built-in LiDAR sensor for large scale 3D rapid mapping. Different aspects have been considered from the architectural surveying perspective and several analyses were carried out focusing on the acquisition phase and the definition of best practices for data collection, the quantitative analysis on the acquired data and their 3D positional accuracy assessment, and the qualitative analysis of the achievable metric products. Despite this paper is a preliminary analysis and deeper studies in various application environment are necessary, the availability of a LiDAR sensor embedded in a tablet or mobile phone, appears promising for rapid surveying purposes. According to test outcomes, the sensor is able to rapidly acquire reliable 3D point clouds suitable for 1:200 architectural rapid mapping; the iPad Pro could represent an interesting novelty also thanks to its price (compared to standard surveying instruments), portability and limited time required both for data acquisition and processing.

Published
2021
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8. Measurement of the nucleon spin structure functions for 0.01<$Q^2$<1 GeV$^2$ using CLAS

Author

Deur, A., Kuhn, S. E., Ripani, M., Zheng, X., Acar, A. G., Achenbach, P., Adhikari, K. P., Alvarado, J. S., Amaryan, M. J., Armstrong, W. R., Atac, H., Avakian, H., Baashen, L., Baltzell, N. A., Barion, L., Bashkanov, M., Battaglieri, M., Benkel, B., Benmokhtar, F., Bianconi, A., Biselli, A. S., Booth, W. A., ossu, F. B, Bosted, P., Boiarinov, S., Brinkmann, K. Th., Briscoe, W. J., Bueltmann, S., Burkert, V. D., Carman, D. S., Chatagnon, P., Chen, J. P., Ciullo, G., Cole, P. L., Contalbrigo, M., Crede, V., D'Angelo, A., Dashyan, N., De Vita, R., Defurne, M., Diehl, S., Djalali, C., Drozdov, V. A., Dupre, R., Egiyan, H., Alaoui, A. El, Fassi, L. El, Elouadrhiri, L., Eugenio, P., Faggert, J. C., Fegan, S., Fersch, R., Filippi, A., Gates, K., Gavalian, G., Gilfoyle, G. P., Gothe, R. W., Guo, L., Hakobyan, H., Hattawy, M., Hauenstein, F., Heddle, D., Hobart, A., Holtrop, M., Ireland, D. G., Isupov, E. L., Jiang, H., Jo, H. S., Joosten, S., Kang, H., Keith, C., Khandaker, M., Kim, W., Klein, F. J., Klimenko, V., Konczykowski, P., Kovacs, K., Kripko, A., Kubarovsky, V., Lanza, L., Lee, S., Lenisa, P., Li, X., Long, E., MacGregor, I. J. D., Marchand, D., Mascagna, V., Matamoros, D., McKinnon, B., Meekins, D., Migliorati, S., Mineeva, T., Mirazita, M., Mokeev, V., Munoz-Camacho, C., Nadel-Turonski, P., Nagorna, T., Neupane, K., Niccolai, S., Osipenko, M., Ostrovidov, A. I., Pandey, P., Paolone, M., Pappalardo, L. L., Paremuzyan, R., Pasyuk, E., Paul, S. J., Phelps, W., Phillips, S. K., Pierce, J., Pilleux, N., Pokhrel, M., Price, J. W., Prok, Y., Radic, A., Reed, T., Richards, J., Rosner, G., Rossi, P., Rusova, A. A., Salgado, C., Schmidt, A., Schumacher, R. A., Sharabian, Y. G., Shirokov, E. V., Shrestha, U., Sirca, S., Sparveris, N., Spreafico, M., Stepanyan, S., Strakovsky, I. I., Strauch, S., Sulkosky, V., Tan, J. A., Tenorio, M., Trotta, N., Tyson, R., Ungaro, M., Upton, D. W., Vallarino, S., Venturelli, L., Voskanyan, H., Voutier, E., Watts, D. P., Wei, X., Wood, M. H., Zachariou, N., Zhang, J., and Zurek, M.

Subjects
Nuclear Experiment
Abstract

The spin structure functions of the proton and the deuteron were measured during the EG4 experiment at Jefferson Lab in 2006. Data were collected for longitudinally polarized electron scattering off longitudinally polarized NH$_3$ and ND$_3$ targets, for $Q^2$ values as small as 0.012 and 0.02 GeV$^2$, respectively, using the CEBAF Large Acceptance Spectrometer (CLAS). This is the archival paper of the EG4 experiment that summaries the previously reported results of the polarized structure functions $g_1$, $A_1F_1$, and their moments $\overline \Gamma_1$, $\overline \gamma_0$, and $\overline I_{TT}$, for both the proton and the deuteron. In addition, we report on new results on the neutron $g_1$ extracted by combining proton and deuteron data and correcting for Fermi smearing, and on the neutron moments $\overline \Gamma_1$, $\overline \gamma_0$, and $\overline I_{TT}$ formed directly from those of the proton and the deuteron. Our data are in good agreement with the Gerasimov-Drell-Hearn sum rule for the proton, deuteron, and neutron. Furthermore, the isovector combination was formed for $g_1$ and the Bjorken integral $\overline \Gamma_1^{p-n}$, and compared to available theoretical predictions. All of our results provide for the first time extensive tests of spin observable predictions from chiral effective field theory ($\chi$EFT) in a $Q^2$ range commensurate with the pion mass. They motivate further improvement in $\chi$EFT calculations from other approaches such as the lattice gauge method., Comment: 33 pages. 26 figures. Data table provided as supplementary material (30 pages latex and csv tables)

Published
2024

9. FROM ARCHIVE DOCUMENTATION TO ONLINE 3D MODEL VISUALIZATION OF NO LONGER EXISTING STRUCTURES: THE TURIN 1911 PROJECT

Author

D. Einaudi, A. Spreafico, F. Chiabrando, and C. Della Coletta

Subjects
Technology, Engineering (General). Civil engineering (General), TA1-2040, Applied optics. Photonics, TA1501-1820
Abstract

Rebuilding the past of cultural heritage through digitization, archiving and visualization by means of digital technology is becoming an emerging issue to ensure the transmission of physical and digital documentation to future generations as evidence of culture, but also to enable present generation to enlarge, facilitate and cross relate data and information in new ways. In this global effort, the digital 3D documentation of no longer existing cultural heritage can be essential for the understanding of past events and nowadays, various digital techniques and tools are developing for multiple purposes.In the present research the entire workflow, starting from archive documentation collection and digitization to the 3D models metrically controlled creation and online sharing, is considered. The technical issues to obtain a detail 3D model are examined stressing limits and potentiality of 3D reconstruction of disappeared heritage and its visualization exploiting three complexes belonging to 1911 Turin World’s Fair.

Published
2020
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11. State of the Art on the Leonardo Sequence: An Evolutionary Study of the Epistemic-Mathematical Field

Author

Milena Carolina dos Santos Mangueira, Francisco Regis Vieira Alves, Paula Maria Machado Cruz Catarino, and Elen Viviani Pereira Spreafico

Abstract

This work is a segment of an ongoing doctoral research in Brazil. The Leonardo numbers and the Leonardo sequence have gained attention from mathematicians and the academic community. Despite being a relatively new sequence within mathematical literature, its discussion has intensified over the past five years, giving rise to other branches, with contributions and associations to other topics in mathematics. Thus, the aim of this study was to construct and present the state of the art of the Leonardo sequence, considering its historical aspects and highlighting works on its evolutionary process in the epistemic-mathematical field, regarding its generalization, complexification, hyper complexification, and combinatorial model during the last five years (2019-2023). The methodology used was a bibliographic study, where the state of the art was carried out through the mapping of publications on the subject. Twenty-four research works related to the key descriptors "Leonardo sequence", "Leonardo numbers", "complexification", "generalization", "hybrids", and "combinatorial model" were found, cataloged, and discussed. From the analysis of these studies, it is noted that its development in pure mathematics has advanced to other branches and discoveries, and that, albeit timidly, research on the subject has emerged directed towards the field of education, especially in the initial teacher training and, particularly, in Brazil.

Published
2024

12. A NEW HANDHELD SCANNER FOR 3D SURVEY OF SMALL ARTIFACTS: THE STONEX F6

Author

G. Patrucco, F. Rinaudo, and A. Spreafico

Subjects
Technology, Engineering (General). Civil engineering (General), TA1-2040, Applied optics. Photonics, TA1501-1820
Abstract

Movable heritage preserved in our museums are an invaluable evidence of our past. In order to properly respond to the need of 3D documentation of these significant assets, in the last few years both range-based and image-based solutions have been developed by researchers operating in the framework of Geomatics with a special focus on reaching a high level of detail and on texture radiometric quality, taking into consideration the intrinsic fragility of these kinds of objects which during the survey require a contactless approach. During the presented research a collection of architectural models representing ancient Nubian temples from “Museo Egizio di Torino” had been digitalized using different techniques; in particular, the wooden maquette of the temple of El-Hilla has been acquired using a new structured light handheld laser scanner, the Stonex F6 SR, and applying a close-range photogrammetric approach. In this paper a comparison between the two approaches is proposed as regards acquisition workflow, final results and suitability as regards digitisation of objects belonging to movable heritage and museum collections.

Published
2019
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13. MULTI-SOURCE APPROACHES FOR COMPLEX ARCHITECTURE DOCUMENTATION: THE 'PALAZZO DUCALE' IN GUBBIO (PERUGIA, ITALY)

Author

G. Patrucco, F. Rinaudo, and A. Spreafico

Subjects
Technology, Engineering (General). Civil engineering (General), TA1-2040, Applied optics. Photonics, TA1501-1820
Abstract

Nowadays, the employment of rapid mapping solutions for architectural survey is more and more considered, not only for the strong reduction of the primary data acquisition times, but also thanks to their adaptability to various contexts, especially in the framework of Cultural Heritage documentation where tailored solutions are required. The combined use of Mobile Mapping Systems (MMS), Unmanned Aerial Vehicles (UAV) for close range aerial image acquisition, and Terrestrial Laser Scanning (TLS) seems to be an effective solution for the architectonic scale compliant to the level of detail and accuracy of 1 : 200, and 1 : 100 scales. The present research tries to evaluate the use of a handheld MMS, the ZEB-Revo RT by Geoslam, an UAV, the DJI Mavic Pro, and a LiDAR system, the Faro Focus3D S 120 by CAM2. The complex case of the documentation metric survey of Palazzo Ducale in Gubbio, the Montefeltro’s Palace, now hosting the museum of itself, allows the comparison of the effectiveness of the used technologies.

Published
2019
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14. First Measurement of Deeply Virtual Compton Scattering on the Neutron with Detection of the Active Neutron

Author

CLAS Collaboration, Hobart, A., Niccolai, S., Čuić, M., Kumerički, K., Achenbach, P., Alvarado, J. S., Armstrong, W. R., Atac, H., Avakian, H., Baashen, L., Baltzell, N. A., Barion, L., Bashkanov, M., Battaglieri, M., Benkel, B., Benmokhtar, F., Bianconi, A., Biselli, A. S., Boiarinov, S., Bondi, M., Booth, W. A., Bossù, F., Brinkmann, K. -Th., Briscoe, W. J., Brooks, W. K., Bueltmann, S., Burkert, V. D., Cao, T., Capobianco, R., Carman, D. S., Chatagnon, P., Ciullo, G., Cole, P. L., Contalbrigo, M., D'Angelo, A., Dashyan, N., De Vita, R., Defurne, M., Deur, A., Diehl, S., Dilks, C., Djalali, C., Dupre, R., Egiyan, H., Alaoui, A. El, Fassi, L. El, Elouadrhiri, L., Fegan, S., Filippi, A., Fogler, C., Gates, K., Gavalian, G., Gilfoyle, G. P., Glazier, D., Gothe, R. W., Gotra, Y., Guidal, M., Hafidi, K., Hakobyan, H., Hattawy, M., Hauenstein, F., Heddle, D., Holtrop, M., Ilieva, Y., Ireland, D. G., Isupov, E. L., Jiang, H., Jo, H. S., Joo, K., Kageya, T., Kim, A., Kim, W., Klimenko, V., Kripko, A., Kubarovsky, V., Kuhn, S. E., Lanza, L., Leali, M., Lee, S., Lenisa, P., Li, X., MacGregor, I. J. D., Marchand, D., Mascagna, V., Maynes, M., McKinnon, B., Meziani, Z. E., Migliorati, S., Milner, R. G., Mineeva, T., Mirazita, M., Mokeev, V., Camacho, C. Muñoz, Nadel-Turonski, P., Naidoo, P., Neupane, K., Niculescu, G., Osipenko, M., Pandey, P., Paolone, M., Pappalardo, L. L., Paremuzyan, R., Pasyuk, E., Paul, S. J., Phelps, W., Pilleux, N., Pokhrel, M., Rafael, S. Polcher, Poudel, J., Price, J. W., Prok, Y., Reed, T., Richards, J., Ripani, M., Ritman, J., Rossi, P., Golubenko, A. A., Salgado, C., Schadmand, S., Schmidt, A., Scott, Marshall B. C., Seroka, E. M., Sharabian, Y. G., Shirokov, E. V., Shrestha, U., Sparveris, N., Spreafico, M., Stepanyan, S., Strakovsky, I. I., Strauch, S., Tan, J. A., Trotta, N., Tyson, R., Ungaro, M., Vallarino, S., Venturelli, L., Tommaso, V., Voskanyan, H., Voutier, E., Watts, D. P, Wei, X., Williams, R., Wood, M. H., Xu, L., Zachariou, N., Zhang, J., Zhao, Z. W., and Zurek, M.

Subjects
High Energy Physics - Experiment, Nuclear Experiment
Abstract

Measuring Deeply Virtual Compton Scattering on the neutron is one of the necessary steps to understand the structure of the nucleon in terms of Generalized Parton Distributions (GPDs). Neutron targets play a complementary role to transversely polarized proton targets in the determination of the GPD $E$. This poorly known and poorly constrained GPD is essential to obtain the contribution of the quarks' angular momentum to the spin of the nucleon. DVCS on the neutron was measured for the first time selecting the exclusive final state by detecting the neutron, using the Jefferson Lab longitudinally polarized electron beam, with energies up to 10.6 GeV, and the CLAS12 detector. The extracted beam-spin asymmetries, combined with DVCS observables measured on the proton, allow a clean quark-flavor separation of the imaginary parts of the GPDs $H$ and $E$., Comment: 7 pages, 6 figures

Published
2024

15. Hallmark discoveries in the biology of non-Wilms tumour childhood kidney cancers

Author

Perotti, Daniela, O’Sullivan, Maureen J., Walz, Amy L., Davick, Jonathan, Al-Saadi, Reem, Benedetti, Daniel J., Brzezinski, Jack, Ciceri, Sara, Cost, Nicholas G., Dome, Jeffrey S., Drost, Jarno, Evageliou, Nicholas, Furtwängler, Rhoikos, Graf, Norbert, Maschietto, Mariana, Mullen, Elizabeth A., Murphy, Andrew J., Ortiz, Michael V., van der Beek, Justine N., Verschuur, Arnauld, Wegert, Jenny, Williams, Richard, Spreafico, Filippo, Geller, James I., van den Heuvel-Eibrink, Marry M., and Hong, Andrew L.

Published
2025
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17. 'TORINO 1911' PROJECT: A CONTRIBUTION OF A SLAM-BASED SURVEY TO EXTENSIVE 3D HERITAGE MODELING

Author

F. Chiabrando, C. Della Coletta, G. Sammartano, A. Spanò, and A. Spreafico

Subjects
Technology, Engineering (General). Civil engineering (General), TA1-2040, Applied optics. Photonics, TA1501-1820
Abstract

In the framework of the digital documentation of complex environments the advanced Geomatics researches offers integrated solution and multi-sensor strategies for the 3D accurate reconstruction of stratified structures and articulated volumes in the heritage domain. The use of handheld devices for rapid mapping, both image- and range-based, can help the production of suitable easy-to use and easy-navigable 3D model for documentation projects. These types of reality-based modelling could support, with their tailored integrated geometric and radiometric aspects, valorisation and communication projects including virtual reconstructions, interactive navigation settings, immersive reality for dissemination purposes and evoking past places and atmospheres. The aim of this research is localized within the “Torino 1911” project, led by the University of San Diego (California) in cooperation with the PoliTo. The entire project is conceived for multi-scale reconstruction of the real and no longer existing structures in the whole park space of more than 400,000 m2, for a virtual and immersive visualization of the Turin 1911 International “Fabulous Exposition” event, settled in the Valentino Park. Particularly, in the presented research, a 3D metric documentation workflow is proposed and validated in order to integrate the potentialities of LiDAR mapping by handheld SLAM-based device, the ZEB REVO Real Time instrument by GeoSLAM (2017 release), instead of TLS consolidated systems. Starting from these kind of models, the crucial aspects of the trajectories performances in the 3D reconstruction and the radiometric content from imaging approaches are considered, specifically by means of compared use of common DSLR cameras and portable sensors.

Published
2018
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18. Positivity violations in marginal structural survival models with time-dependent confounding: a simulation study on IPTW-estimator performance

Author

Spreafico, Marta

Subjects
Statistics - Methodology
Abstract

In longitudinal observational studies, marginal structural models (MSMs) are a class of causal models used to analyse the effect of an exposure on the (time-to-event) outcome of interest, while accounting for exposure-affected time-dependent confounding. In the applied literature, inverse probability of treatment weighting (IPTW) has been widely adopted to estimate MSMs. An essential assumption for IPTW-based MSMs is the positivity assumption, which ensures that, for any combination of measured confounders among individuals, there is a non-zero probability of receiving each possible treatment strategy. Positivity is crucial for valid causal inference through IPTW-based MSMs, but is often overlooked compared to confounding bias. Positivity violations may also arise due to randomness, in situations where the assignment to a specific treatment is theoretically possible but is either absent or rarely observed in the data, leading to near violations. These situations are common in practical applications, particularly when the sample size is small, and they pose significant challenges for causal inference. This study investigates the impact of near-positivity violations on estimates from IPTW-based MSMs in survival analysis. Two algorithms are proposed for simulating longitudinal data from hazard-MSMs, accommodating near-positivity violations, a time-varying binary exposure, and a time-to-event outcome. Cases of near-positivity violations, where remaining unexposed is rare within certain confounder levels, are analysed across various scenarios and weight truncation (WT) strategies. This work aims to serve as a critical warning against overlooking the positivity assumption or naively applying WT in causal studies using longitudinal observational data and IPTW.

Published
2024

21. Smoking and alcohol by HPV status in head and neck cancer: a Mendelian randomization study

Author

Thakral, Abhinav, Lee, John JW., Hou, Tianzhichao, Hueniken, Katrina, Dudding, Tom, Gormley, Mark, Virani, Shama, Olshan, Andrew, Diergaarde, Brenda, Ness, Andrew R., Waterboer, Tim, Smith-Byrne, Karl, Brennan, Paul, Hayes, D. Neil, Sanderson, Eleanor, Brown, M. Catherine, Huang, Sophie, Bratman, Scott V., Spreafico, Anna, De Almeida, John, Davies, Joel C., Bierut, Laura, Macfarlane, Gary J., Lagiou, Pagona, Lagiou, Areti, Polesel, Jerry, Agudo, Antonio, Alemany, Laia, Ahrens, Wolfgang, Healy, Claire M., Conway, David I., Nygard, Mari, Canova, Cristina, Holcatova, Ivana, Richiardi, Lorenzo, Znaor, Ariana, Goldstein, David P., Hung, Rayjean J., Xu, Wei, Liu, Geoffrey, and Espin-Garcia, Osvaldo

Published
2024
Full Text
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23. Secondary beams at high-intensity electron accelerator facilities

Author

Battaglieri, Marco, Bianconi, Andrea, Bondí, Mariangela, De Vita, Raffaella, Fulci, Antonino, Gosta, Giulia, Grazzi, Stefano, Jo, Hyon-Suk, Lee, Changhui, Mandaglio, Giuseppe, Mascagna, Valerio, Nagorna, Tetiana, Pilloni, Alessandro, Spreafico, Marco, Tagliapietra, Luca J, Venturelli, Luca, and Vittorini, Tommaso

Subjects
Physics - Accelerator Physics, High Energy Physics - Experiment, Nuclear Experiment
Abstract

The interaction of a high-current $O$(100~\textmu A), medium energy $O$(10\,GeV) electron beam with a thick target $O$(1m) produces an overwhelming shower of standard matter particles in addition to hypothetical Light Dark Matter particles. While most of the radiation (gamma, electron/positron, and neutron) is contained in the thick target, deep penetrating particles (muons, neutrinos, and light dark matter particles) propagate over a long distance, producing high-intense secondary beams. Using sophisticated Monte Carlo simulations based on FLUKA and GEANT4, we explored the characteristics of secondary muons and neutrinos and (hypothetical) dark scalar particles produced by the interaction of Jefferson Lab 11 GeV intense electron beam with the experimental Hall-A beam dump. Considering the possible beam energy upgrade, this study was repeated for a 20 GeV CEBAF beam.

Published
2023
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24. Joint modelling of recurrent and terminal events with discretely-distributed non-parametric frailty: application on re-hospitalizations and death in heart failure patients

Author

Masci, Chiara, Spreafico, Marta, and Ieva, Francesca

Subjects
Statistics - Methodology
Abstract

In the context of clinical and biomedical studies, joint frailty models have been developed to study the joint temporal evolution of recurrent and terminal events, capturing both the heterogeneous susceptibility to experiencing a new episode and the dependence between the two processes. While discretely-distributed frailty is usually more exploitable by clinicians and healthcare providers, existing literature on joint frailty models predominantly assumes continuous distributions for the random effects. In this article, we present a novel joint frailty model that assumes bivariate discretely-distributed non-parametric frailties, with an unknown finite number of mass points. This approach facilitates the identification of latent structures among subjects, grouping them into sub-populations defined by a shared frailty value. We propose an estimation routine via Expectation-Maximization algorithm, which not only estimates the number of subgroups but also serves as an unsupervised classification tool. This work is motivated by a study of patients with Heart Failure (HF) receiving ACE inhibitors treatment in the Lombardia region of Italy. Recurrent events of interest are hospitalizations due to HF and terminal event is death for any cause.

Published
2023

25. Beam Charge Asymmetries for Deeply Virtual Compton Scattering on the Proton at CLAS12

Author

Voutier, E., Burkert, V., Niccolai, S., Paremuzyan, R., Afanasev, A., Alvarado-Galeano, J. -S., Atoui, M., Barion, L., Battaglieri, M., Bernauer, J., Bianconi, A., Bondi, M., Briscoe, W., Camsonne, A., Capobianco, R., Celentano, A., Chatagnon, P., Chetry, T., Ciullo, G., Cole, P., Contalbrigo, M., Costantini, G., Defurne, M., Deur, A., De Vita, R., Diehl, S., Dupré, R., Elouadrhiri, L., Fernando, I., Filippi, A., Forest, T., Girod, F. -X., Gosta, G., Grames, J., Gueye, P., Habet, S., Hattawy, M., Higinbotham, D., Hobart, A., Hyde, C., Joo, K., Kim, A., Klimenko, V., Kubarovsky, V., Leali, M., Lenisa, P., Marchand, D., Marsicano, L., Mascagna, V., Matamoros, D., McCaughan, M., McKinnon, B., Migliorati, S., Mitra, H. S., Movsisyan, A., Muñoz-Camacho, C., Osipenko, M., Ouillon, M., Pappalardo, L., Pasquini, B., Pasyuk, E., Pilleux, N., Poelker, M., Raue, B., Ripani, M., Santos, R., Schmidt, A., Singh, R., Sokhan, D., Spreafico, M., Stoler, P., Strakovsky, I., Taiuti, M., Venturelli, L., Wang, P. -K., Wei, X., Zhao, Z., Collaboration, the CLAS, and Group, the Jefferson Lab Positron Working

Subjects
Nuclear Experiment, High Energy Physics - Experiment
Abstract

The parameterization of the nucleon structure through Generalized Parton Distributions (GPDs) shed a new light on the nucleon internal dynamics. For its direct interpretation, Deeply Virtual Compton Scattering (DVCS) is the golden channel for GPDs investigation. The DVCS process interferes with the Bethe-Heitler (BH) mechanism to constitute the leading order amplitude of the $eN \to eN\gamma$ process. The study of the $ep\gamma$ reaction with polarized positron and electron beams gives a complete set of unique observables to unravel the different contributions to the $ep \gamma$ cross section. This separates the different reaction amplitudes, providing a direct access to their real and imaginary parts which procures crucial constraints on the model dependences and associated systematic uncertainties on GPDs extraction. The real part of the BH-DVCS interference amplitude is particularly sensitive to the $D$-term which parameterizes the Gravitational Form Factors of the nucleon. The separation of the imaginary parts of the interference and DVCS amplitudes provides insights on possible higher-twist effects. We propose to measure the unpolarized and polarized Beam Charge Asymmetries (BCAs) of the $\vec{e}^{\pm}p \to e^{\pm}p \gamma$ process on an unpolarized hydrogen target with {\tt CLAS12}, using polarized positron and electron beams at 10.6 GeV. The azimuthal and $t$-dependences of the unpolarized and polarized BCAs will be measured over a large $(x_B,Q^2)$ phase space using a 100 day run with a luminosity of 0.66$\times 10^{35}$cm$^{-2}\cdot$s$^{-1}$., Comment: Proposal to the Jefferson Lab Program Advisory Committee (PAC51)

Published
2023

26. Prospective manipulation of the gut microbiome with microbial ecosystem therapeutic 4 (MET4) in HPV-related locoregionally-advanced oropharyngeal cancer squamous cell carcinoma (LA-OPSCC) undergoing primary chemoradiation: ROMA2 study

Author

Oliva, Marc, Heirali, Alya, Watson, Geoffrey, Rooney, Ashley M., Cochrane, Kyla, Jennings, Sarah, Taylor, Rachel, Xu, Minge, Hosni, Ali, Hope, Andrew, Bratman, Scott V., Chepeha, Douglas, Weinreb, Ilan, Perez-Ordonez, Bayardo, Nin, Ricard Mesia, Waldron, John, Xu, Wei, Hansen, Aaron R., Siu, Lillian L., Coburn, Bryan, and Spreafico, Anna

Published
2024
Full Text
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27. Beam Spin Asymmetry Measurements of Deeply Virtual $\pi^0$ Production with CLAS12

Author

Kim, A., Diehl, S., Joo, K., Kubarovsky, V., Achenbach, P., Akbar, Z., Alvarado, J. S., Armstrong, Whitney R., Atac, H., Avakian, H., Gayoso, C. Ayerbe, Barion, L., Battaglieri, M., Bedlinskiy, I., Benkel, B., Bianconi, A., Biselli, A. S., Bondi, M., Bossù, F., Boiarinov, S., Brinkmann, K. T., Briscoe, W. J., Brooks, W. K., Bueltmann, S., Burkert, V. D., Capobianco, R., Carman, D. S., Carvajal, J. C., Celentano, A., Charles, G., Chatagnon, P., Chesnokov, V., Chetry, T., Ciullo, G., Clary, B., Clash, G., Cole, P. L., Contalbrigo, M., Costantini, G., Crede, V., D'Angelo, A., Dashyan, N., DeVita, R., Defurne, M., Deur, A., Dilks, C., Djalali, C., Dupre, R., Egiyan, H., Ehrhart, M., ElAlaoui, A., ElFassi, L., Fegan, S., Filippi, A., Fogler, C., Gavalian, G., Gilfoyle, G. P., Gosta, G., Girod, F. X., Glazier, D. I., Golubenko, A. A., Gothe, R. W., Guo, L., Hafidi, K., Hakobyan, H., Hattawy, M., Hauenstein, F., Hayward, T. B., Heddle, D., Hobart, A., Holtrop, M., Hung, Yu-Chun, Ilieva, Y., Ireland, D. G., Isupov, E., Jo, H. S., Johnston, R., Joosten, S., Khachatryan, M., Khanal, A., Kim, W., Klimenko, V., Kripko, A., Kuhn, S. E., Lanza, L., Leali, M., Kabir, M. L., Lee, S., Lenisa, P., Li, X., MacGregor, I . J . D., Marchand, D., Mascagna, V., McKinnon, B., Matamoros, D., Migliorati, S., Mineeva, T., Mirazita, M., Mokeev, V., Moran, P., MunozCamacho, C., Naidoo, P., Neupane, K., Nguyen, D., Niccolai, S., Niculescu, G., Osipenko, M., Ouillon, M., Pandey, P., Paolone, M., Pappalardo, L. L., Paremuzyan, R., Pasyuk, E., Paul, S. J., Phelps, W., Pilleux, N., Pokhrel, M., Poudel, J., Price, J. W., Prok, Y., Radic, A., Ramasubramanian, N., Reed, Trevor, Richards, J., Ripani, M., Ritman, J., Rossi, P., Sabatié, F., Salgado, C., Schadmand, S., Schmidt, A., Sharabian, Y. G., Shirokov, E. V., Shrestha, U., Sokhan, D., Sparveris, N., Spreafico, M., Stepanyan, S., Strakovsky, I. I., Strauch, S., Tan, J., Trotta, N., Tyson, R., Ungaro, M., Vallarino, S., Venturelli, L., Voskanyan, H., Voutier, E., Watts, D. P., Wei, X., Wishart, R., Wood, M. H., Yurov, M., Zachariou, N., Zhang, J., Ziegler, V., and Zurek, M.

Subjects
Nuclear Experiment
Abstract

The new experimental measurements of beam spin asymmetry were performed for the deeply virtual exclusive $\pi^0$ production in a wide kinematic region with the photon virtualities $Q^2$ up to 8 GeV$^2$ and the Bjorken scaling variable $x_B$ in the valence regime. The data were collected by the CEBAF Large Acceptance Spectrometer (CLAS12) at Jefferson Lab with longitudinally polarized 10.6 GeV electrons scattered on an unpolarized liquid-hydrogen target. Sizable asymmetry values indicate a substantial contribution from transverse virtual photon amplitudes to the polarized structure functions.The interpretation of these measurements in terms of the Generalized Parton Distributions (GPDs) demonstrates their sensitivity to the chiral-odd GPD $\bar E_T$, which contains information on quark transverse spin densities in unpolarized and polarized nucleons and provides access to the proton's transverse anomalous magnetic moment. Additionally, the data were compared to a theoretical model based on a Regge formalism that was extended to the high photon virtualities., Comment: arXiv admin note: substantial text overlap with arXiv:2210.14557

Published
2023

28. Strong Interaction Physics at the Luminosity Frontier with 22 GeV Electrons at Jefferson Lab

Author

Accardi, A., Achenbach, P., Adhikari, D., Afanasev, A., Akondi, C. S., Akopov, N., Albaladejo, M., Albataineh, H., Albrecht, M., Almeida-Zamora, B., Amaryan, M., Androić, D., Armstrong, W., Armstrong, D. S., Arratia, M., Arrington, J., Asaturyan, A., Austregesilo, A., Avagyan, H., Averett, T., Gayoso, C. Ayerbe, Bacchetta, A., Balantekin, A. B., Baltzell, N., Barion, L., Barry, P. C., Bashir, A., Battaglieri, M., Bellini, V., Belov, I., Benhar, O., Benkel, B., Benmokhtar, F, Bentz, W., Bertone, V., Bhatt, H., Bianconi, A., Bibrzycki, L., Bijker, R., Binosi, D., Biswas, D., Boër, M., Boeglin, W., Bogacz, S. A., Boglione, M., Bondí, M., Boos, E. E., Bosted, P., Bozzi, G., Brash, E. J., Briceño, R. A., Brindza, P. D., Briscoe, W. J., Brodsky, S. J, Brooks, W. K., Burkert, V. D., Camsonne, A., Cao, T., Cardman, L. S., Carman, D. S., Carpinelli, M, Cates, G. D., Caylor, J., Celentano, A., Celiberto, F. G., Cerutti, M., Chang, Lei, Chatagnon, P., Chen, C., Chen, J-P, Chetry, T., Christopher, A., Christy, E., Chudakov, E., Cisbani, E., Cloët, I. C., Cobos-Martinez, J. J., Cohen, E. O., Colangelo, P., Cole, P. L., Constantinou, M., Contalbrigo, M., Costantini, G., Cosyn, W., Cotton, C., Courtoy, A., Dusa, S. Covrig, Crede, V., Cui, Z. -F., D'Angelo, A., Döring, M., Dalton, M. M., Danilkin, I., Davydov, M., Day, D., De Fazio, F., De Napoli, M., De Vita, R., Dean, D. J., Defurne, M., Deur, A., Devkota, B., Dhital, S., Di Nezza, P., Diefenthaler, M., Diehl, S., Dilks, C., Ding, M., Djalali, C., Dobbs, S., Dupré, R., Dutta, D., Edwards, R. G., Egiyan, H., Ehinger, L., Eichmann, G., Elaasar, M., Elouadrhiri, L., Alaoui, A. El, Fassi, L. El, Emmert, A., Engelhardt, M., Ent, R., Ernst, D. J, Eugenio, P., Evans, G., Fanelli, C., Fegan, S., Fernández-Ramírez, C., Fernandez, L. A., Fernando, I. P., Filippi, A., Fischer, C. S., Fogler, C., Fomin, N., Frankfurt, L., Frederico, T., Freese, A., Fu, Y., Gamberg, L., Gan, L., Gao, F., Garcia-Tecocoatzi, H., Gaskell, D., Gasparian, A., Gates, K, Gavalian, G., Ghoshal, P. K., Giachino, A., Giacosa, F., Giannuzzi, F., Gilfoyle, G. -P., Girod, F-X, Glazier, D. I., Gleason, C., Godfrey, S., Goity, J. L., Golubenko, A. A., Gonzàlez-Solís, S., Gothe, R. W., Gotra, Y., Griffioen, K., Grocholski, O., Grube, B., Guèye, P., Guo, F. -K., Guo, Y., Guo, L., Hague, T. J., Hammoud, N., Hansen, J. -O., Hattawy, M., Hauenstein, F., Hayward, T., Heddle, D., Heinrich, N., Hen, O., Higinbotham, D. W., Higuera-Angulo, I. M., Blin, A. N. Hiller, Hobart, A., Hobbs, T., Holmberg, D. E, Horn, T., Hoyer, P., Huber, G. M., Hurck, P., Hutauruk, P. T. P., Ilieva, Y., Illari, I., Ireland, D. G, Isupov, E. L., Italiano, A., Jaegle, I., Jarvis, N. S., Jenkins, DJ, Jeschonnek, S., Ji, C-R., Jo, H. S., Jones, M., Jones, R. T., Jones, D. C., Joo, K., Junaid, M., Kageya, T., Kalantarians, N., Karki, A., Karyan, G., Katramatou, A. T., Kay, S. J. D, Kazimi, R., Keith, C. D., Keppel, C., Kerbizi, A., Khachatryan, V., Khanal, A., Khandaker, M., Kim, A., Kinney, E. R., Kohl, M., Kotzinian, A., Kriesten, B. T., Kubarovsky, V., Kubis, B., Kuhn, S. E., Kumar, V., Kutz, T., Leali, M., Lebed, R. F., Lenisa, P., Leskovec, L., Li, S., Li, X., Liao, J., Lin, H. -W., Liu, L., Liuti, S., Liyanage, N., Lu, Y., MacGregor, I. J. D., Mack, D. J., Maiani, L, Mamo, K. A., Mandaglio, G., Mariani, C., Markowitz, P., Marukyan, H., Mascagna, V., Mathieu, V., Maxwell, J., Mazouz, M., McCaughan, M., McKeown, R. D., McKinnon, B., Meekins, D., Melnitchouk, W., Metz, A., Meyer, C. A., Meziani, Z. -E., Mezrag, C., Michaels, R., Miller, G. A., Mineeva, T., Miramontes, A. S., Mirazita, M., Mizutani, K., Mkrtchyan, H., Mkrtchyan, A., Moffit, B., Mohanmurthy, P., Mokeev, V. I., Monaghan, P., Montaña, G., Montgomery, R., Moretti, A., Chàvez, J. M. Morgado, Mosel, U., Movsisyan, A., Musico, P., Nadeeshani, S. A, Nadolsky, P. M., Nakamura, S. X., Nazeer, J., Nefediev, A. V., Neupane, K., Nguyen, D., Niccolai, S., Niculescu, I., Niculescu, G., Nocera, E. R., Nycz, M., Olness, F. I., Ortega, P. G., Osipenko, M., Pace, E., Pandey, B, Pandey, P., Papandreou, Z., Papavassiliou, J., Pappalardo, L. L., Paredes-Torres, G., Paremuzyan, R., Park, S., Parsamyan, B., Paschke, K. D., Pasquini, B., Passemar, E., Pasyuk, E., Patel, T., Paudel, C., Paul, S. J., Peng, J-C., Pentchev, L., Perrino, R., Perry, R. J., Peters, K., Petratos, G. G., Phelps, W., Piasetzky, E., Pilloni, A., Pire, B., Pitonyak, D., Pitt, M. L., Polosa, A. D., Pospelov, M., Postuma, A. C., Poudel, J., Preet, L., Prelovsek, S., Price, J. W., Prokudin, A., Puckett, A. J. R., Pybus, J. R., Qin, S. -X., Qiu, J. -W., Radici, M., Rashidi, H., Rathnayake, A. D, Raue, B. A., Reed, T., Reimer, P. E., Reinhold, J., Richard, J. -M., Rinaldi, M., Ringer, F., Ripani, M., Ritman, J., West, J. Rittenhouse, Rivero-Acosta, A., Roberts, C. D., Rodas, A., Rodini, S., Rodríguez-Quintero, J., Rogers, T. C., Rojo, J., Rossi, P., Rossi, G. C., Salmè, G., Santiesteban, S. N., Santopinto, E., Sargsian, M., Sato, N., Schadmand, S., Schmidt, A., Schmidt, S. M, Schnell, G., Schumacher, R. A., Schweitzer, P., Scimemi, I., Scott, K. C, Seay, D. A, Segovia, J., Semenov-Tian-Shansky, K., Seryi, A., Sharda, A. S, Shepherd, M. R., Shirokov, E. V., Shrestha, S., Shrestha, U., Shvedunov, V. I., Signori, A., Slifer, K. J., Smith, W. A., Somov, A., Souder, P., Sparveris, N., Spizzo, F., Spreafico, M., Stepanyan, S., Stevens, J. R., Strakovsky, I. I., Strauch, S., Strikman, M., Su, S., Sumner, B. C. L., Sun, E., Suresh, M., Sutera, C., Swanson, E. S., Szczepaniak, A. P, Sznajder, P., Szumila-Vance, H., Szymanowski, L., Tadepalli, A. -S., Tadevosyan, V., Tamang, B., Tarasov, V. V., Thiel, A., Tong, X. -B., Tyson, R., Ungaro, M., Urciuoli, G. M., Usman, A., Valcarce, A., Vallarino, S., Vaquera-Araujo, C. A., Venturelli, L., Vera, F., Vladimirov, A., Vossen, A., Wagner, J., Wei, X., Weinstein, L. B., Weiss, C., Williams, R., Winney, D., Wojtsekhowski, B., Wood, M. H., Xiao, T., Xu, S. -S., Ye, Z., Yero, C., Yuan, C. -P., Yurov, M., Zachariou, N., Zhang, Z., Zhao, Z. W., Zhao, Y., Zheng, X., Zhou, X., Ziegler, V., Zihlmann, B., de Paula, W, and de Téramond, G. F.

Subjects
Nuclear Experiment, High Energy Physics - Experiment, High Energy Physics - Phenomenology, Nuclear Theory
Abstract

This document presents the initial scientific case for upgrading the Continuous Electron Beam Accelerator Facility (CEBAF) at Jefferson Lab (JLab) to 22 GeV. It is the result of a community effort, incorporating insights from a series of workshops conducted between March 2022 and April 2023. With a track record of over 25 years in delivering the world's most intense and precise multi-GeV electron beams, CEBAF's potential for a higher energy upgrade presents a unique opportunity for an innovative nuclear physics program, which seamlessly integrates a rich historical background with a promising future. The proposed physics program encompass a diverse range of investigations centered around the nonperturbative dynamics inherent in hadron structure and the exploration of strongly interacting systems. It builds upon the exceptional capabilities of CEBAF in high-luminosity operations, the availability of existing or planned Hall equipment, and recent advancements in accelerator technology. The proposed program cover various scientific topics, including Hadron Spectroscopy, Partonic Structure and Spin, Hadronization and Transverse Momentum, Spatial Structure, Mechanical Properties, Form Factors and Emergent Hadron Mass, Hadron-Quark Transition, and Nuclear Dynamics at Extreme Conditions, as well as QCD Confinement and Fundamental Symmetries. Each topic highlights the key measurements achievable at a 22 GeV CEBAF accelerator. Furthermore, this document outlines the significant physics outcomes and unique aspects of these programs that distinguish them from other existing or planned facilities. In summary, this document provides an exciting rationale for the energy upgrade of CEBAF to 22 GeV, outlining the transformative scientific potential that lies within reach, and the remarkable opportunities it offers for advancing our understanding of hadron physics and related fundamental phenomena., Comment: Updates to the list of authors; Preprint number changed from theory to experiment; Updates to sections 4 and 6, including additional figures

Published
2023

29. Strong interaction physics at the luminosity frontier with 22 GeV electrons at Jefferson Lab

Author

Accardi, A., Achenbach, P., Adhikari, D., Afanasev, A., Akondi, C. S., Akopov, N., Albaladejo, M., Albataineh, H., Albrecht, M., Almeida-Zamora, B., Amaryan, M., Androić, D., Armstrong, W., Armstrong, D. S., Arratia, M., Arrington, J., Asaturyan, A., Austregesilo, A., Avakian, H., Averett, T., Gayoso, C. Ayerbe, Bacchetta, A., Balantekin, A. B., Baltzell, N., Barion, L., Barry, P. C., Bashir, A., Battaglieri, M., Bellini, V., Belov, I., Benhar, O., Benkel, B., Benmokhtar, F., Bentz, W., Bertone, V., Bhatt, H., Bianconi, A., Bibrzycki, L., Bijker, R., Binosi, D., Biswas, D., Boër, M., Boeglin, W., Bogacz, S. A., Boglione, M., Bondí, M., Boos, E. E., Bosted, P., Bozzi, G., Brash, E. J., Briceño, R. A., Brindza, P. D., Briscoe, W. J., Brodsky, S. J., Brooks, W. K., Burkert, V. D., Camsonne, A., Cao, T., Cardman, L. S., Carman, D. S., Carpinelli, M., Cates, G. D., Caylor, J., Celentano, A., Celiberto, F. G., Cerutti, M., Chang, L., Chatagnon, P., Chen, C., Chen, J.-P., Chetry, T., Christopher, A., Christy, E., Chudakov, E., Cisbani, E., Cloët, I. C., Cobos-Martinez, J. J., Cohen, E. O., Colangelo, P., Cole, P. L., Constantinou, M., Contalbrigo, M., Costantini, G., Cosyn, W., Cotton, C., Courtoy, A., Dusa, S. Covrig, Crede, V., Cui, Z.-F., D’Angelo, A., Döring, M., Dalton, M. M., Danilkin, I., Davydov, M., Day, D., De Fazio, F., De Napoli, M., De Vita, R., Dean, D. J., Defurne, M., de Paula, W., de Téramond, G. F., Deur, A., Devkota, B., Dhital, S., Di Nezza, P., Diefenthaler, M., Diehl, S., Dilks, C., Ding, M., Djalali, C., Dobbs, S., Dupré, R., Dutta, D., Edwards, R. G., Egiyan, H., Ehinger, L., Eichmann, G., Elaasar, M., Elouadrhiri, L., Alaoui, A. El, Fassi, L. El, Emmert, A., Engelhardt, M., Ent, R., Ernst, D. J., Eugenio, P., Evans, G., Fanelli, C., Fegan, S., Fernández-Ramírez, C., Fernandez, L. A., Fernando, I. P., Filippi, A., Fischer, C. S., Fogler, C., Fomin, N., Frankfurt, L., Frederico, T., Freese, A., Fu, Y., Gamberg, L., Gan, L., Gao, F., Garcia-Tecocoatzi, H., Gaskell, D., Gasparian, A., Gates, K., Gavalian, G., Ghoshal, P. K., Giachino, A., Giacosa, F., Giannuzzi, F., Gilfoyle, G.-P., Girod, F.-X., Glazier, D. I., Gleason, C., Godfrey, S., Goity, J. L., Golubenko, A. A., Gonzàlez-Solís, S., Gothe, R. W., Gotra, Y., Griffioen, K., Grocholski, O., Grube, B., Guèye, P., Guo, F.-K., Guo, Y., Guo, L., Hague, T. J., Hammoud, N., Hansen, J.-O., Hattawy, M., Hauenstein, F., Hayward, T., Heddle, D., Heinrich, N., Hen, O., Higinbotham, D. W., Higuera-Angulo, I. M., Hiller Blin, A. N., Hobart, A., Hobbs, T., Holmberg, D. E., Horn, T., Hoyer, P., Huber, G. M., Hurck, P., Hutauruk, P. T. P., Ilieva, Y., Illari, I., Ireland, D. G., Isupov, E. L., Italiano, A., Jaegle, I., Jarvis, N. S., Jenkins, D. J., Jeschonnek, S., Ji, C.-R., Jo, H. S., Jones, M., Jones, R. T., Jones, D. C., Joo, K., Junaid, M., Kageya, T., Kalantarians, N., Karki, A., Karyan, G., Katramatou, A. T., Kay, S. J. D., Kazimi, R., Keith, C. D., Keppel, C., Kerbizi, A., Khachatryan, V., Khanal, A., Khandaker, M., Kim, A., Kinney, E. R., Kohl, M., Kotzinian, A., Kriesten, B. T., Kubarovsky, V., Kubis, B., Kuhn, S. E., Kumar, V., Kutz, T., Leali, M., Lebed, R. F., Lenisa, P., Leskovec, L., Li, S., Li, X., Liao, J., Lin, H.-W., Liu, L., Liuti, S., Liyanage, N., Lu, Y., MacGregor, I. J. D., Mack, D. J., Maiani, L., Mamo, K. A., Mandaglio, G., Mariani, C., Markowitz, P., Marukyan, H., Mascagna, V., Mathieu, V., Maxwell, J., Mazouz, M., McCaughan, M., McKeown, R. D., McKinnon, B., Meekins, D., Melnitchouk, W., Metz, A., Meyer, C. A., Meziani, Z.-E., Mezrag, C., Michaels, R., Miller, G. A., Mineeva, T., Miramontes, A. S., Mirazita, M., Mizutani, K., Mkrtchyan, A., Mkrtchyan, H., Moffit, B., Mohanmurthy, P., Mokeev, V. I., Monaghan, P., Montaña, G., Montgomery, R., Moretti, A., Chàvez, J. M. Morgado, Mosel, U., Movsisyan, A., Musico, P., Nadeeshani, S. A., Nadolsky, P. M., Nakamura, S. X., Nazeer, J., Nefediev, A. V., Neupane, K., Nguyen, D., Niccolai, S., Niculescu, I., Niculescu, G., Nocera, E. R., Nycz, M., Olness, F. I., Ortega, P. G., Osipenko, M., Pace, E., Pandey, B., Pandey, P., Papandreou, Z., Papavassiliou, J., Pappalardo, L. L., Paredes-Torres, G., Paremuzyan, R., Park, S., Parsamyan, B., Paschke, K. D., Pasquini, B., Passemar, E., Pasyuk, E., Patel, T., Paudel, C., Paul, S. J., Peng, J.-C., Pentchev, L., Perrino, R., Perry, R. J., Peters, K., Petratos, G. G., Phelps, W., Piasetzky, E., Pilloni, A., Pire, B., Pitonyak, D., Pitt, M. L., Polosa, A. D., Pospelov, M., Postuma, A. C., Poudel, J., Preet, L., Prelovsek, S., Price, J. W., Prokudin, A., Puckett, A. J. R., Pybus, J. R., Qin, S.-X., Qiu, J.-W., Radici, M., Rashidi, H., Rathnayake, A. D., Raue, B. A., Reed, T., Reimer, P. E., Reinhold, J., Richard, J.-M., Rinaldi, M., Ringer, F., Ripani, M., Ritman, J., West, J. Rittenhouse, Rivero-Acosta, A., Roberts, C. D., Rodas, A., Rodini, S., Rodríguez-Quintero, J., Rogers, T. C., Rojo, J., Rossi, P., Rossi, G. C., Salmè, G., Santiesteban, S. N., Santopinto, E., Sargsian, M., Sato, N., Schadmand, S., Schmidt, A., Schmidt, S. M., Schnell, G., Schumacher, R. A., Schweitzer, P., Scimemi, I., Scott, K. C., Seay, D. A., Segovia, J., Semenov-Tian-Shansky, K., Seryi, A., Sharda, A. S., Shepherd, M. R., Shirokov, E. V., Shrestha, S., Shrestha, U., Shvedunov, V. I., Signori, A., Slifer, K. J., Smith, W. A., Somov, A., Souder, P., Sparveris, N., Spizzo, F., Spreafico, M., Stepanyan, S., Stevens, J. R., Strakovsky, I. I., Strauch, S., Strikman, M., Su, S., Sumner, B. C. L., Sun, E., Suresh, M., Sutera, C., Swanson, E. S., Szczepaniak, A. P., Sznajder, P., Szumila-Vance, H., Szymanowski, L., Tadepalli, A.-S., Tadevosyan, V., Tamang, B., Tarasov, V. V., Thiel, A., Tong, X.-B., Tyson, R., Ungaro, M., Urciuoli, G. M., Usman, A., Valcarce, A., Vallarino, S., Vaquera-Araujo, C. A., Venturelli, L., Vera, F., Vladimirov, A., Vossen, A., Wagner, J., Wei, X., Weinstein, L. B., Weiss, C., Williams, R., Winney, D., Wojtsekhowski, B., Wood, M. H., Xiao, T., Xu, S.-S., Ye, Z., Yero, C., Yuan, C.-P., Yurov, M., Zachariou, N., Zhang, Z., Zhao, Y., Zhao, Z. W., Zheng, X., Zhou, X., Ziegler, V., and Zihlmann, B.

Published
2024
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30. Hodge de Rham theory and analytic torsion for spaces with horn type singularities

Author

Spreafico, Mauro

Subjects
Mathematics - Functional Analysis
Abstract

We study the global analytic properties of a space $X$ with a horn type singularity. In particular, we introduce some de Rham complex of square integrable forms and we describe its homology and the spectral properties of the associated Hodge Laplace operator. All this is applied to produce a suitable description of the analytic torsion of $X$ and to prove an extension of the Cheeger M\"{u}ller theorem.

Published
2023

31. Localised analytic torsion and relative analytic torsion for non compact Lie groups of type I

Author

Della Vedova, A. and Spreafico, M.

Subjects
Mathematics - Functional Analysis, Mathematics - Differential Geometry, Mathematics - Representation Theory
Abstract

Let $G$ be a (non compact) connected simply connected locally compact second countable Lie group, either abelian or unimodular of type I, and $\rho$ an irreducible unitary representation of $G$. Then, we define the analytic torsion of $G$ localised at the representation $\rho$. Next, let $\Gamma$ a discrete cocompact subgroup of $G$. We use the localised analytic torsion to define the relative analytic torsion of the pair $(G,\Gamma)$, and we prove that it coincides with the Lott $L^2$ analytic torsion of a covering space. We illustrate these constructions analysing in some details two examples: the abelian case, and the case $G=H$, the Heisenberg group.

Published
2023

32. First measurement of hard exclusive $\pi^- \Delta^{++}$ electroproduction beam-spin asymmetries off the proton

Author

Diehl, S., Trotta, N., Joo, K., Achenbach, P., Akbar, Z., Armstrong, W. R., Atac, H., Avakian, H., Baashen, L., Baltzell, N. A., Barion, L., Bashkanov, M., Battaglieri, M., Bedlinskiy, I., Benmokhtar, F., Bianconi, A., Biselli, A. S., Bossu, F., Brinkmann, K. -T., Briscoe, W. J., Bulumulla, D., Burkert, V., Capobianco, R., Carman, D. S., Carvajal, J. C., Celentano, A., Charles, G., Chatagnon, P., Chesnokov, V., Ciullo, G., Cole, P. L., Contalbrigo, M., Costantini, G., Crede, V., D'Angelo, A., Dashyan, N., De Vita, R., Deur, A., Djalali, C., Dupre, R., Ehrhart, M., Alaoui, A. El, Fassi, L. El, Elouadrhiri, L., Fegan, S., Filippi, A., Gavalian, G., Glazier, D. I., Golubenko, A. A., Gosta, G., Gothe, R. W., Gotra, Y., Griffioen, K., Hafidi, K., Hakobyan, H., Hattawy, M., Hayward, T. B., Heddle, D., Hobart, A., Holtrop, M., Illari, I., Ireland, D. G., Isupov, E. L., Jo, H. S., Johnston, R., Keller, D., Khachatryan, M., Khanal, A., Kim, A., Kim, W., Klimenko, V., Kripko, A., Kubarovsky, V., Kuhn, S. E., Lagerquist, V., Lanza, L., Leali, M., Lee, S., Lenisa, P., Li, X., MacGregor, I . J . D., Marchand, D., Mascagna, V., Matousek, G., McKinnon, B., McLauchlin, C., Meziani, Z. E., Migliorati, S., Milner, R. G., Mineeva, T., Mirazita, M., Mokeev, V., Moran, P., Camacho, C. Munoz, Naidoo, P., Neupane, K., Niccolai, S., Niculescu, G., Osipenko, M., Pandey, P., Paolone, M., Pappalardo, L. L., Paremuzyan, R., Paul, S. J., Phelps, W., Pilleux, N., Pokhrel, M., Poudel, J., Price, J. W., Prok, Y., Radic, A., Raue, B. A., Reed, T., Richards, J., Ripani, M., Ritman, J., Rossi, P., Sabatie, F., Salgado, C., Schadmand, S., Schmidt, A., Sharabian, Y. G., Shrestha, U., Sokhan, D., Sparveris, N., Spreafico, M., Stepanyan, S., Strakovsky, I., Strauch, S., Turisini, M., Tyson, R., Ungaro, M., Vallarino, S., Venturelli, L., Voskanyan, H., Voutier, E., Watts, D. P., Wei, X., Williams, R., Wishart, R., Wood, M. H., Yurov, M., Zachariou, N., Zhao, Z. W., and Zurek, M.

Subjects
High Energy Physics - Experiment
Abstract

The polarized cross section ratio $\sigma_{LT'}/\sigma_{0}$ from hard exclusive $\pi^{-} \Delta^{++}$ electroproduction off an unpolarized hydrogen target has been extracted based on beam-spin asymmetry measurements using a 10.2 GeV / 10.6 GeV incident electron beam and the CLAS12 spectrometer at Jefferson Lab. The study, which provides the first observation of this channel in the deep-inelastic regime, focuses on very forward-pion kinematics in the valence regime, and photon virtualities ranging from 1.5 GeV$^{2}$ up to 7 GeV$^{2}$. The reaction provides a novel access to the $d$-quark content of the nucleon and to $p \rightarrow \Delta^{++}$ transition generalized parton distributions. A comparison to existing results for hard exclusive $\pi^{+} n$ and $\pi^{0} p$ electroproduction is provided, which shows a clear impact of the excitation mechanism, encoded in transition generalized parton distributions, on the asymmetry.

Published
2023
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33. Anabolic effects and inhibition of interleukin 6 production induced by neridronate on human osteoblasts

Author

S. Niccolini, F. Chellini, F. Baldi, P. Ferrata, D. Gambera, C. Capperucci, B. Frediani, A. Spreafico, L. Bocchi, and R. Marcolongo

Subjects
Medicine, Internal medicine, RC31-1245
Abstract

Bisphosphonates (BPs) are pharmacological compounds widely used in the treatment of a variety of bone-related diseases, particularly where the bone-turnover is skewed in favour of osteolysis. The mechanisms by which BPs reduce bone-resorption directly acting on osteoclasts (OCs) are now largely clarified even at molecular level. The researches concerning the BPs effects on osteoblasts (OBs) have instead shown variable results. Objectives: We have investigated the efficacy of neridronate (NER), an amino-BP, as anabolic agent on human OBs. Moreover, we have tried to verify if NER is able to negatively modulate the production of IL-6 on OBs stimulated or not by the pro-inflammatory cytokine Il-1b. Methods: We have tested if different concentrations of NER (from 10-11M to 10-3M), added to primary human OB cultures, could affect the cells number, the endogenous cellular alkaline phosphatase (ALP) activity, the collagen I (COLI) synthesis, the formation of mineralized nodules and the IL-6 production. Our experimental approach was performed testing a wide range of NER concentrations because, under physiological conditions, OBs seems to be exposed to variable and transient levels of the drug. Results: Our results show that NER doesn’t negatively affect in vitro the viability, proliferation and cellular activity of human OBs, even after 20 days of exposure to concentrations ²10-5 M (therapeutic dose). In addition, NER seems to enhance the differentiation of cultured OBs in mature bone-forming cells. A maximum increase of COL-I synthesis (+25% after 4 days; p

Published
2011
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34. Topological phases of graphene-Kagome systems

Author

de Souza, A. B. Felix, Spreafico, L., Faria, D., and Latgé, A.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

The growing skill in the synthesis processes of new materials has intensified the interest in exploring the properties of systems modeled by more complex lattices. Two-dimensional super-honeycomb lattices, have been investigated in metallic organic frameworks. They turned out as a significant route to the emergence of localized electronic responses, manifested as flat bands in their structure with topological isolating behavior. A natural inquiry is a complete analysis of their topological phases in the presence of electronic correlation effects. Here we analyse of the electron-electron correlation effects via Hubbard mean-field approximation on the topological phases of 2D and quasi-1D graphene-Kagome lattices. The 2D spin conductivity phase's diagrams describe metallic, trivial and topological insulating behaviors, considering different energy coupling and electronic occupations. Our results pave the way to smart-engineered nanostructured devices with relevant applications in spintronics and transport responses., Comment: Article submitted to Physical Review B, 6 pages, 8 figures

Published
2023

35. Tonic TNF conditioning of macrophages safeguards stimulus‐specific inflammatory responses

Author

Luecke, Stefanie, Adelaja, Adewunmi, Guo, Xiaolu, Sen, Supriya, Spreafico, Roberto, Singh, Apeksha, Liu, Yi, Taylor, Brooks, Diaz, Jessica, Cheng, Quen, and Hoffmann, Alexander

Subjects
Genetics, Aetiology, Underpinning research, 1.1 Normal biological development and functioning, 2.1 Biological and endogenous factors, Inflammatory and immune system, Pathogen-Associated Molecular Pattern Molecules, Tumor Necrosis Factor-alpha, Signal Transduction, NF-kappa B, Macrophages, epigenome integrity, immune sentinel cells, inflammation, NF kappa B dynamics, tonic TNF, NFκB dynamics, Biochemistry and Cell Biology, Developmental Biology
Abstract

Tumor necrosis factor (TNF) is a key inflammatory cytokine that warns recipient cells of a nearby infection or tissue damage. Acute exposure to TNF activates characteristic oscillatory dynamics of the transcription factor NFκB and induces a characteristic gene expression program; these are distinct from the responses of cells directly exposed to pathogen-associated molecular patterns (PAMPs). Here, we report that tonic TNF exposure is critical for safeguarding TNF's specific functions. In the absence of tonic TNF conditioning, acute exposure to TNF causes (i) NFκB signaling dynamics that are less oscillatory and more like PAMP-responsive NFκB dynamics, (ii) immune gene expression that is more similar to the Pam3CSK4 response program, and (iii) broader epigenomic reprogramming that is characteristic of PAMP-responsive changes. We show that the absence of tonic TNF signaling effects subtle changes to TNF receptor availability and dynamics such that enhanced pathway activity results in non-oscillatory NFκB. Our results reveal tonic TNF as a key tissue determinant of the specific cellular responses to acute paracrine TNF exposure, and their distinction from responses to direct exposure to PAMPs.

Published
2023

36. Diagnostic magnetic resonance imaging characteristics of congenital mesoblastic nephroma: a retrospective multi-center International Society of Pediatric Oncology-Renal Tumor Study Group (SIOP-RTSG) radiology panel study

Author

van der Beek, Justine N., Schenk, Jens-Peter, Morosi, Carlo, Watson, Tom A., Coma, Ana, Graf, Norbert, Chowdhury, Tanzina, Ramírez-Villar, Gema L., Spreafico, Filippo, Welter, Nils, Dzhuma, Kristina, van Tinteren, Harm, de Krijger, Ronald R., van den Heuvel-Eibrink, Marry M., and Littooij, Annemieke S.

Published
2024
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37. Multimodal detection of molecular residual disease in high-risk locally advanced squamous cell carcinoma of the head and neck

Author

Sanz-Garcia, Enrique, Zou, Jinfeng, Avery, Lisa, Spreafico, Anna, Waldron, John, Goldstein, David, Hansen, Aaron, Cho, B. C. John, de Almeida, John, Hope, Andrew, Hosni, Ali, Hahn, Ezra, Perez-Ordonez, Bayardo, Zhao, Zhen, Smith, Christopher, Zheng, Yangqiao, Singaravelan, Nitthusha, Bratman, Scott V., and Siu, Lillian L.

Published
2024
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40. First CLAS12 measurement of DVCS beam-spin asymmetries in the extended valence region

Author

CLAS Collaboration, Christiaens, G., Defurne, M., Sokhan, D., Achenbach, P., Akbar, Z., Amaryan, M. J., Atac, H., Avakian, H., Gayoso, C. Ayerbe, Baashen, L., Baltzell, N. A., Barion, L., Bashkanov, M., Battaglieri, M., Bedlinskiy, I., Benkel, B., Benmokhtar, F., Bianconi, A., Biselli, A. S., Bondi, M., Booth, W. A., Bossù, F., Boiarinov, S., Brinkmann, K. -Th., Briscoe, W. J., Bueltmann, S., Bulumulla, D., Burkert, V. D., Cao, T., Carman, D. S., Carvajal, J. C., Celentano, A., Chatagnon, P., Chesnokov, V., Chetry, T., Ciullo, G., Clash, G., Cole, P. L., Contalbrigo, M., Costantini, G., D'Angelo, A., Dashyan, N., De Vita, R., Deur, A., Diehl, S., Dilks, C., Djalali, C., Dupre, R., Egiyan, H., Ehrhart, M., Alaoui, A. El, Fassi, L. El, Elouadrhiri, L., Fegan, S., Filippi, A., Gates, K., Gavalian, G., Ghandilyan, Y., Gilfoyle, G. P., Girod, F. X., Glazier, D. I., Golubenko, A. A., Gosta, G., Gothe, R. W., Gotra, Y., Griffioen, K. A., Guidal, M., Hafidi, K., Hakobyan, H., Hattawy, M., Hauenstein, F., Hayward, T. B., Heddle, D., Hobart, A., Holmberg, D. E., Holtrop, M., Ilieva, Y., Ireland, D. G., Isupov, E. L., Jo, H. S., Kabir, M. L., Keller, D., Khachatryan, M., Khanal, A., Kim, W., Kripko, A., Kubarovsky, V., Kuhn, S. E., Lagerquist, V., Lanza, L., Leali, M., Lee, S., Lenisa, P., Li, X., Livingston, K., MacGregor, I . J . D., Marchand, D., Mascagna, V., Matousek, G., McKinnon, B., McLauchlin, C., Meziani, Z. E., Migliorati, S., Milner, R. G., Mineeva, T., Mirazita, M., Mokeev, V., Molina, E., Camacho, C. Munoz, Nadel-Turonski, P., Naidoo, P., Neupane, K., Niccolai, S., Nicol, M., Niculescu, G., Osipenko, M., Ouillon, M., Pandey, P., Paolone, M., Pappalardo, L. L., Paremuzyan, R., Pasyuk, E., Paul, S. J., Phelps, W., Pilleux, N., Pokhrel, M., Poudel, J., Price, J. W., Prok, Y., Radic, A., Ramasubramanian, N., Raue, B. A., Reed, T., Richards, J., Ripani, M., Ritman, J., Rossi, P., Sabatié, F., Salgado, C., Schadmand, S., Schmidt, A., Scott, M. B. C., Sharabian, Y. G., Shirokov, E. V., Shrestha, U., Simmerling, P., Sparveris, N., Spreafico, M., Stepanyan, S., Strakovsky, I. I., Strauch, S., Tan, J. A., Trotta, N., Turisini, M., Tyson, R., Ungaro, M., Vallarino, S., Venturelli, L., Voskanyan, H., Voutier, E., Watts, D. P., Wei, X., Williams, R., Wishart, R., Wood, M. H., Zachariou, N., Zhang, J., Zhao, Z. W., Ziegler, V., and Zurek, M.

Subjects
High Energy Physics - Experiment
Abstract

Deeply virtual Compton scattering (DVCS) allows one to probe Generalized Parton Distributions (GPDs) describing the 3D structure of the nucleon. We report the first measurement of the DVCS beam-spin asymmetry using the CLAS12 spectrometer with a 10.2 and 10.6 GeV electron beam scattering from unpolarised protons. The results greatly extend the $Q^2$ and Bjorken-$x$ phase space beyond the existing data in the valence region and provide over 2000 new data points measured with unprecedented statistical uncertainty, setting new, tight constraints for future phenomenological studies., Comment: Revised Figure 4 and discussion around the number of effective ANNs after Bayesian reweighting

Published
2022

41. On the anomaly terms in Cheeger-M\'uller theorem on spaces with conical singularities

Author

Hartmann, Luiz and Spreafico, Mauro

Subjects
Mathematics - Differential Geometry, Mathematics - Algebraic Topology, Mathematics - Spectral Theory, 58J52, 11M36, 57Q10
Abstract

We prove that the anomaly term appearing in the ratio between Reidemeister torsion and analytic torsion for a space with a conical singularity vanishes in the smooth case. Moreover, we show that such anomaly term is non trivial for the cone over a torus.

Published
2022

43. On Leonardo Numbers and Fibonacci Fundamental System

Author

Spreafico, Elen Viviani Pereira, Catarino, Paula Maria Machado Cruz, Gayoso Martínez, Víctor, editor, Yilmaz, Fatih, editor, Queiruga-Dios, Araceli, editor, Rasteiro, Deolinda M.L.D., editor, Martín-Vaquero, Jesús, editor, and Mierluş-Mazilu, Ion, editor

Published
2024
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44. Prospective Life Cycle Assessment Based on Patent Analysis to Support Eco-design

Author

Spreafico, Christian, Landi, Daniele, Russo, Davide, Chaari, Fakher, Series Editor, Gherardini, Francesco, Series Editor, Ivanov, Vitalii, Series Editor, Haddar, Mohamed, Series Editor, Cavas-Martínez, Francisco, Editorial Board Member, di Mare, Francesca, Editorial Board Member, Kwon, Young W., Editorial Board Member, Trojanowska, Justyna, Editorial Board Member, Xu, Jinyang, Editorial Board Member, Carfagni, Monica, editor, Furferi, Rocco, editor, Di Stefano, Paolo, editor, and Governi, Lapo, editor

Published
2024
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45. A first-in-human phase 1/2 dose-escalation study of MAK683 (EED inhibitor) in patients with advanced malignancies

Author

Ribrag, Vincent, Iglesias, Lara, De Braud, Filippo, Ma, Brigette, Yokota, Tomoya, Zander, Thomas, Spreafico, Anna, Subbiah, Vivek, Illert, Anna L., Tan, Daniel, Santoro, Armando, Munster, Pamela N., Suehiro, Youko, Wang, Yongsheng, Ji, Dong-Mei, Chen, Shuqi, Beltz, Karen, Suenaga, Naoko, Ramkumar, Thiruvamoor, Luo, Fangjun, Lai, Clinton, and Wainberg, Zev A.

Published
2025
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46. International benchmarking of stage at diagnosis for six childhood solid tumours (the BENCHISTA project): a population-based, retrospective cohort study

Author

Aitken, Joanne, O'Neill, Leisa, Youlden, Danny, Hackl, Monika, Ladenstein, Ruth, Van Eycken, Elizabeth, Van Damme, Nancy, Frazier, Lindsay, De Camargo, Beatriz, de Oliveira Santos, Marceli, Lima, Carlos A., Ramos, Walmiro, Cabral Formigosa, Lucrecia Aline, Ferreira dos Santos, Luciana, Casale, Claudina Agnese, Patrus Pena, Gil, Natívio, Juliana, Asturian Laporte, Cyntia, Santos de Menezes Miranda, Cristiana, Bastos Daniel, Cristiane, Nonata de Paulo, Raimunda, Veneziano, Donaldo B., Pontes de Aquino, Angela, Fernandes de Souza, Paulo Cesar, Valentim Leite, Rebeca, Valerianova, Zdravka, Konstantinov, Dobrin, Gupta, Sumit, Pole, Jason D., Sekerija, Mario, Stary, Jan, Sterba, Jaroslav, Hjalgrim, Lisa L., Falck Winther, Jeanette, Paapsi, Keiu, Lacour, Brigitte, Desandes, Emmanuel, Clavel, Jacqueline, Poulalhon, Claire, Ressing, Meike, Truebenbach, Claudia, Spix, Claudia, Petridou, Eleni T., Bouka, Evdoxia, Jakab, Zsuzsanna, Garami, Miklos, Galasso, Rocco, Sampietro, Giuseppe, Vetrano, Francesco, Sessa, Marcella, Maule, Milena M., Sacerdote, Carlotta, Ballotari, Paola, De Santis, Emilia, Ferrante, Margherita, Ragusa, Rosalia, Mian, Michael, Boni, Luca, Rognoni, Magda, Amodio, Rosalba, Boschetti, Lorenza, Cuccaro, Francesco, Bruno, Danila, Russo, Antonio G., Gervasi, Federico, Gambino, Maria L., Borciani, Elisabetta, Michiara, Maria, Mangone, Lucia, Spagnoli, Gianbattista, Ferretti, Stefano, Falcini, Fabio, Spata, Eugenia, Manasse, Sonia, Coccia, Paola, Bella, Francesca, Caldarella, Adele, Intrieri, Teresa, Scuderi, Tiziana, Rizzello, Roberto V., Zorzi, Manuel, Guzzinati, Stefano, Murray, Deirdre, Matsuda, Tomohiro, Nakata, Kayo, Azzopardi, Miriam J., Børge Johannesen, Tom, Dahlen, Aina H., Zeller, Bernward, Kowalczyk, Jerzy, Raciborska, Anna, Ferreira, Ana M., Caldas, Gabriela, Bucurenci, Mihaela, Coza, Dana, Zadnik, Vesna, Lopez de Munain, Arantza, Almela-Vich, Fernando, Jeghalef-El Karoui, Noura, Marcos-Gragera, Rafael, José Sanchez, Maria, Aragonés, Nuria, Parra-Blázquez, David, Chirlaque, Maria Dolores, Guevara, Marcela, Pardo, Elena, Peris-Bonet, Rafael, Cañete Nieto, Adela, Carulla, Marià, Lähteenmäki, Päivi, Kuehni, Claudia E., Redmond, Shelagh M., Visser, Otto, Karim-Kos, Henrike, Stevens, Sarah, Irvine, Lucy, Stiller, Charles, Gavin, Anna, Fitzpatrick, Deirdre, Bennet, Damien, Morrison, David S., Smith, Karen, Huws, Dyfed Wyn, Smits, Stephanie, Gaspar, Nathalie, Spreafico, Filippo, Bailey, Simon, Klein, Méric, Di Cataldo, Andrea, Capocaccia, Riccardo, Polanco, Angela, Green, Giles, Botta, Laura, Didonè, Fabio, Lopez-Cortes, Angela, Nieto, Adela Cañete, Hjalgrim, Lisa L, Stiller, Charles A, Gatta, Gemma, and Pritchard-Jones, Kathy

Published
2025
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47. Development of a prediction model for tube feeding dependence in HPV-associated oropharyngeal cancer patients undergoing chemoradiotherapy

Author

Dietrich, Nicholas, Watson, Erin, Tadic, Tony, Martino, Rosemary, Bratman, Scott, Cho, John, de Almeida, John, Eng, Lawson, Goldstein, David, Hahn, Ezra, Hope, Andrew, Hosni, Ali, Kim, John, Malik, Nauman, O’Sullivan, Brian, Garcia, Enrique Sanz, Siu, Lillian, Spreafico, Anna, Su, Susie, Tsai, Jillian, Waldron, John, Yao, Christopher MKL., Huang, Shao Hui, and McPartlin, Andrew J.

Published
2025
Full Text
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