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Relevance. Over the past decade, manufacturers of oral care products have expanded the possibilities of solving the problem of hypersensitivity of teeth due to a variety of new modern technologies, which provides an opportunity to increase the effectiveness of active oral care product components. The study aimed to investigate desensitizing, remineralizing and anti-caries effectiveness of Asepta Extra Sensitive toothpaste to confirm the toothpaste properties stated by the manufacturer. Material and methods. Forty-nine people, aged from 24 to 58 years, participated in the clinical testing of the toothpaste. The study used the Orekhova – Ulitovskiy tooth sensitivity index to evaluate the desensitizing toothpaste and determined the severity of dental hyperesthesia using diagnostic tests. We objectively assessed the functional state of the enamel using the Okushko – Kosareva enamel resistance test. The study evaluated the electrical conductivity of the dentin hypersensitivity to investigate the anti-caries effect.Result. The desensitizing effectiveness increased to 64.59 ± 5.72% by the end of the study, according to the Orekhova – Ulitovskiy sensitivity index. The dentin hypersensitivity hypersensitivity decreased, according to the diagnostic tests. The tooth sensitivity reduction effectiveness increased – 62.22 ± 6.84%, according to the tooth tactile sensitivity assessment by linear advancement of the probe along the tooth surface. The analysis of the remineralizing parameter showed positive changes in the enamel resistance test. The remineralizing parameter value amounted to 21.49 ± 1.91%, and the remineralizing effectiveness reached 61.05 ± 2.98%. The values of anti-caries action and anti-caries effectiveness were 3.31 ± 0.52 mA and 29.72 ± 1.92%, respectively, according to the method of dentin hypersensitivity electrical conductivity evaluation with Asepta Extra Sensitive toothpaste. The desensitizing, remineralizing and anti-caries results of Asepta Extra Sensitive toothpaste use were high.Conclusion. The development of dental health strengthening measures determines the significance of oral care products in tooth sensitivity prevention in the population, which plays a leading role in planning individual programs to prevent major dental diseases.

Relevance. Odontogenic infection is one of the most important problems of dental science. The variety of anti-inflammatory oral hygiene products determines the need for targeted selection of preventive toothpastes and rinses, balms, foams, elixirs, as well as monitoring and training the algorithm of hygienic measures for a patient with an odontogenic infection. The aim of the study was to study the hygienic status of the adult population for the selection of individual oral hygiene products for odontogenic infection, taking into account social and hygienic factors.Materials and methods. The study examined the prevalence of odontogenic infection in the adult population to determine the need for professional care and dental education. The study involved 198 people without somatic pathology, who were allocated into four groups according to the performed oral care and taking into account the dental status and the intensity of oral microbiota formation in the adult population. The patients were followed-up every week for one month. The study examined the simplified oral hygiene index by GreenVermillion (OHI-S), PMA index and Mühlemann and Son sulcus bleeding index, which allowed calculating the effectiveness of oral care products.Results. The preventive care effectiveness evaluation showed an increase in the cleansing effect in the adult population over the entire study period. The anti-inflammatory effectiveness analysis demonstrated positive changes: by the end of the study, the PMA index was 51.52 ± 3.40% in group 1; it increased by a factor of 3 and amounted to 44.17 ± 2.77% in group 2; 56.51 ± 4.61% – in group 3, 48.95 ± 3.60% – in group 4. The Mühlemann and Son sulcus bleeding index demonstrated the changes in the periodontal tissue condition and amounted to 52.78 ± 3.62% in group 1, 44.11 ± 3.54% in group 2, 54.97 ± 3.98% in group 3, 47.78 ± 2.73% in group 4.Conclusions. The development of oral health promotion measures determines the significance of oral care products for the prevention of odontogenic infection in the adult population, which plays a crucial role in the individual program planning for the main dental disease prevention.

Major transformations have taken place throughout history, radically changing people's way of life. This can be noted in particular in the area of employment. In just the last few centuries, it has gone from predominantly agrarian employment, manual work and natural specialization to the technology-based image of the service-sector worker. The purpose of the article is to comprehend and conceptualize the process of forming a new employment paradigm through the prism of global challenges. The hypothesis is that in the modern world, employment is becoming increasingly blurred, combining features of different eras, which results in an intensification of social stratification and labor market segmentation. The research is based on the methodological principles of compiling a systematic review and consists of the following steps: goal setting and study design, selection of relevant literature according to the defined criteria, generalization and analytical review of selected sources, presentation of results. The analysis highlights the key trends in the field of employment at the current stage of social development. Among them are concentration of the labor force in the tertiary sector, destandardization and increased flexibility of employment, changes in the economy's requirements for human capital, etc. Special attention is paid to the influence of global challenges on the future of work under single-factor and complex scenarios of its development. The authors provide an analytical review of international experience in overcoming the negative consequences of employment transformation. The paper concludes by offering conceptual understanding of the emerging paradigm of employment and highlighting its cognitive features. The results obtained contribute to the development of the discussion on the future of work, related opportunities and threats. The practical significance of the study lies in identifying promising directions of state policy to regulate employment in the face of modern challenges.

В статье раскрывается понятие рекламы и его эволюция, значение рекламы в рыночной экономике, её положительные и негативные стороны, особенности интернет-рекламы. Также рассмотрена динамика российского рекламного рынка.

The purpose of the article was to study the influence of the COVID-19 pandemic on the sustainability of workers. The paper analyses relevant domestic and foreign publications in the field of labour and employment. There is no single point of view regarding remote employment as one of the most effective ways to preserve health of workers. Among the main disadvantages of remote employment are the lack of live communication and contacts with colleagues, difficulties with organizing the workflow in the technological aspect, as well as the difficulty of combining work and household responsibilities. Researchers have an unambiguous position on reducing the number of working hours, fears of losing jobs or earnings – such risks are increasing in many regions of the world, and part of the population has already directly faced such problems. At the same time, for example, fears of losing a job largely depend on the form of ownership, the specifics of the organization’s activities, etc. The study pays particular attention to the situation of certain categories of workers and vulnerable segments of society in the labour market. The authors outline the prospects for remote employment and maintaining the sustainability of the position of workers in the new socio-economic reality.Keywords: coronavirus pandemic, COVID-19, employment, labor market, labor relations, non-standard employment, remote employment, transformation of employment, unemployment

Background The COVID-19 pandemic has dramatically influenced healthcare systems as well as the training environment worldwide. Numerous concerns have been raised about the disruption of cardiology training due to the social and physical distancing. We aimed to characterize the changes made in cardiology training in response to the COVID-19 pandemic and the personal perception of the new educational realities amongst first-year residents of the university clinic of the national medical research centre. Methods The institutional educational program underwent urgent and significant adaptation. Functions of the e-learning platform were extended in the purpose of the accumulation of the recorded lectures, online discussions, meetings, case-based clinical scenarios, virtual simulations, and regular virtual clinical rounds 2 times per week. Using an online 7-items survey, we analyzed the practical experience of 33 clinical cardiology trainees who worked within “red” and “green” zones and their personal perception of the distance educational technologies. Results At the peak of the pandemic outbreak, 40.6% of the residents have transferred into facilities restructured for COVID-19 patients for a median of 3 (1; 4) months. According to the responses they did not experience changes in the direct supervision time by their trainers and have achieved a higher level of independence in the procedural activity (arterial and central venous catheterization, CPR, performing intubation and invasive ventilation), decision making (such as prescription of anticoagulants and antibiotics, treatment of comorbid conditions), interpretation of the laboratory (acid-base balance, markers of myocardial, kidney and liver damage) and instrumental findings (ECG, echocardiography, coronary tomography). Despite the challenges, 75% of the trainees positively assessed their training in infectious settings. Due to the accidental contacts with COVID-19 patients and the associated need for 14-days quarantine residents who remained in the “green” zone experienced a reduction in direct supervision time from 57 to 17 hours per week (−70%) and were lack of procedural skills improvement. However, using the wide range of the educational resources provided in demand resulted in an increase in their learning time (plus 8 hours per week) with improvement in cardiology knowledge. Positive feedback was received from 85% of these residents with mention of the improvement of self-management. Conclusions Despite worldwide adoption of the educational program to the distant learning cardiology residents can experience different educational scenarios in the different setting due to COVID-19 cases surge. Combination of direct supervision, teaching remotely with staff support, case-based discussions, wider use of simulation, telemedicine, and social media engagement are urgently needed for adaptation of the educational programs in order to reduce the continuing shortage of specialists. Funding Acknowledgement Type of funding sources: None.

The existing problems of rolls handling facilities, as in the case of PJSC "Magnitogorsk Iron and Steel Works" Long products shop were considered in terms of a proposition to have them solved by means of introduction of an automated information system for accounting and management. A review of literary sources on issues of information technology, management, logistics and organization of rolls handling facilities was performed. The basic provisions of automated information system have been developed, and the issue of rolls handling facilities management on its basis is considered.

Drawing is the basic operation of wire manufacturing. At drawing a wire contacts with a die resulting in decrease of its diameter. During this interaction wire microstructure changes, especially on the contact area between a die and a wire. Specificity of microstructure changing on outer surface of carbon steel wire at drawing and its combination with torsion is presented in the paper. Using optical microscopy, it was found out that in the outer surface of carbon steel wire a narrow layer of highly deformed grains is formed. It is shown that thickness of this layer depends on the deformational processing intensity and is very specific depending on carbon content of the wire.

Статья посвящена влиянию информационно-коммуникационных технологий на процесс обучения. Авторы отмечают, что использование информационных технологий значительно повысит качество образовательного процесса.

The paper presents the analysis of the results of application of monofilament suture based on polyhydroxyalkanoates (PHAs) in comparison with suture materials "Vicryl" and "Kaprofil" in experiment with Chinchilla rabbits. It was proved that the use of the PHA-based suture is accompanied by minimally pronounced local tissue response.

The paper presents the results of clinical trials of wound dressing based on cellulose in comparison with wound dressing "Gidrokoll" in patients with acute purulent soft tissue infections. It is proved that the wound covering based on cellulose more efficient, contribute to the rapid and intensive purification and epithelialization of infected wounds.

The article deals with the role and directions of the social innovations’ impact on regional development. In retrospect, the author considers the essence of social innovations. The functional features of social innovations have been highlighted. A conceptual model of the social innovations’ impact on regional development has been proposed. The results obtained made it possible to formulate the main vectors of social innovation development as a factor of social progress and economic growth of a region.

Objectives: the aim of the study was to investigate clinical features of thyroid function in pregnant woman in the region of natural iodine deficiency. Methods: serum thyroid stimulating hormone (TSH), free thyroxin (fT4) concentrations, urine excretion of iodine were measured. The structure and volume of thyroid gland were defined by palpation and ultrasonography. The 150 pregnant women (50 in every trimester) were included in study. Results: median of urine iodine excretion was 72.5 mkg/l, that confirm mild iodine deficiency in the region. During pregnancy median of urine excretion of iodine is significantly lower in third trimester (51.0 mkg/l), than in first (93.0 mkg/l) and in second (86.1 mkg/l). The goiter was registered more often in third trimester of pregnancy. The level of fT4 was decreased in third trimester of pregnancy. Key words: iodine deficiency, goiter, hypothyroidism pregnancy.

Based on a generalization of the method of Sturmian expansions to the case of many-electron systems, a fundamentally new approach was developed for the construction of a complete set of intermediate states in many-body perturbation theory thereby avoiding integration over states of the continuous spectrum. A complete system of eigenfunctions of the generalized eigenvalue problem for the one-electron Hartree-Fock equation with a factor before the energy operator and fixed values of the Lagrange multipliers is used as a basis of single-particle virtual orbitals for an initial approximation to the eigenfunctions of the Hartree-Fock self-consistent field method. In the case of bound states, the spectrum of the effective operator is purely discrete, thus permitting one to completely eliminate integration over continuum virtual orbitals in applying methods of many-body perturbation theory to atomic and molecular calculations for a number of cases. As a consequence, one manages to avoid a number of the technical difficulties associated with inclusion of such states. The possibilities of the developed approach are illustrated in application to the investigation of the interaction of many-electron atoms with external fields.