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The purpose of the study: to establish gender and age characteristics of the prevalence and risk of developing hypertension (AH) among outpatients living in the city of Tambov, according to electronic medical records (EMR).The information from the EMC of 47,113 people aged 20-99 living in Tambov was used. The prevalence rate (per 100 people) and the relative risk of developing (RR) hypertension in different sex and age groups were calculated.The prevalence of hypertension among people aged 20-99 was 45.7 cases, in women it is higher than in men by 23% (50.1 vs 38.4 cases). With age, there is an increase in the prevalence of hypertension from 1.7% in 20-24 to 86.8% in 70-74 years old people. In the transition from a smaller age group to a larger one, the increase in the prevalence of hypertension among the female cohort averaged 22.5%, among the male cohort - an average of 17.2%. The RR for the development of hypertension among the female cohort aged 20-99 years is 1.2 times higher compared to the male cohort of the same age. At the age of 25-34, the OR for the development of hypertension prevails among the male cohort, at 45-89 years old - among the female cohort.The high level and established differences in the prevalence and risk of developing hypertension determine the need to develop recommendations for hypertension screening among the population, stratification into risk groups, prevention and treatment, focused on different age and gender groups.

Taking into account gender- and age-related features, to examine the structure of comorbidity in outpatients with essential hypertension residing in the city of Tambov. Material and Methods — This research was an observational cross-sectional study based on data extracted from 47,113 electronic medical records (EMRs) of patients 20-99 years of age residing in Tambov. The study included 29,282 (62.2%) women and 17831 (37.8%) men. Results — Essential hypertension is habitually associated with osteochondrosis (41.5% of patients with hypertension), cerebrovascular diseases (35.1%), arthrosis (28.3%), ischemic heart disease (IHD) (28.7%), menopausal disorders (17.5%), pancreatic diseases (15.4%), diabetes mellitus (14.7%), benign mammary dysplasia (14.2%), retinal diseases (12.9%), disorders of lipoprotein metabolism (12.4%), senile cataract (10.6%), gastritis and duodenitis (10.7%), varicose veins (10.1%), and thyroid diseases (10.0%). IHD is more common among men with hypertension, while other comorbidities are more characteristic for women. The most striking gender-related difference was associated with the finding that women with hypertension had varicose veins as a comorbidity (RR=1.398; 95% CI 1.376-1.422), while the smallest difference between genders related to retinal diseases (RR=1.065; 95% CI 1.038-1.092). IHD was strongly associated with the male gender (RR=1.101; 95% CI 1.056-1.148). Three diseases were more often associated with hypertension in the age range of 80-89 years (cerebrovascular disease, IHD, osteochondrosis); some of the diseases had the highest incidence in the age range of 60-69 years, and other disorders occurred in the age range of 40-59 years. Conclusion — The gender- and age-related features of comorbid pathology associated with essential hypertension among urban residents revealed in this study are extremely important in the clinical practice of a local general practitioner for developing optimal patient-oriented treatment plans.

One of the determinants of the birth rate trends is value system and attitudes of the population, especially young people. Increasingly building a successful career, achieving high social status and financial independence become the priorities of modern youth. The presence of children in this case could considered being a hindrance in achieving these goals. The emergence of the childfree phenomenon indicates the processes of changing the family-value orientations of the population. With the aim to analyze the attitude of the medical university students to the childfree phenomenon in dynamics, we conducted surveys among Sechenov University students in 2009 and 2019. A comparative analysis of the survey results allowed us to make conclusions about a decrease in the number of students with chronic diseases (54.0% and 63.9% respectively deny the presence of chronic diseases), a decrease in the number of students with bad habits (31.0% and 14.5% of students smoke, 16.0% and 9.2% drink alcohol, respectively), a decrease in the number of students with children from 20.0% to 2.3%, as well as an increase in the number of students who are not ready for independent childrearing from 59.0% to 76.2%. In addition, our findings show an increase in number of students aware about childfree phenomenon (from 36.0% to 84.8%) and a more loyal attitude towards it among students (3.0% in 2009 and 18.5% of students in 2019).

The inclusion of public health and health care measures in labor functions of professional standards of medical specialists increased significance of mastering of these standards by students during specialty training, since on this depends their successful completion of primary accreditation of specialists and implementation of job descriptions in the course of daily activities. The purpose of the study was to analyze factors determining qualitative of mastering the discipline "Public health and Health Care" by students of medical educational organizations. The analytical, logical, statistical, questionnaire survey and direct ranking methods were applied. The sampling of 316 students of the Sechenov University was involved in survey using questionnaire of 17 closed questions. The study established that the determining factors effecting quality of mastering by students the discipline "Public health and Health Care" are the need to use by physicians this knowledge in the course of their daily activities; the need of students to pass profile exam; the determination of up to 40% of trainees to work as heads of structural units or professionals of health care and public health; the dedication of student; organization of educational process at the Chair; the professionalism of faculty; the application of active learning methods in classroom; organization of career guidance among students.

The recovering of reproductive health of women is one of prospective means to stabilize fertility. The purpose of the study is to investigate medical, demographic and social risk factors of discontinuing screening and treatment of infertility in women of the Tambov Oblast. The materials and methods. The comparative data analysis of women who discontinued infertility screening and treatment prior to referral to auxiliary reproductive technologies (n = 239) and women who were factually referred to these technologies (n = 206). The results of the study. The risk factors for women of discontinuing screening and treatment of infertility included age (OR = 1.070; 95% CI 1,035-1,105; p

Information on the main indicators of the Pandemic COVID-19 is published daily for each subject of the Russian Federation. Of interest is the comparative ranking of regions in terms of new cases, active cases that have recovered from COVID-19, the allocation of homogeneous groups of regions in terms of the distribution of COVID-19. Since several indicators, respectively, the ranking of regions can be several options: the same regions with a high level of morbidity can be characterized by lower mortality from COVID-19 and vice versa, which will shift their position in the overall rating assessment. Such a state complicates the perception of the situation with the COVID-19 pandemic in the spatial-territorial context. In this regard, it makes sense to develop a certain latent integral indicator for assessing the COVID-19 pandemic process, which will allow comparing the subjects of the Russian Federation with each other in order to develop practical recommendations.

Moscow State Medical University» (Sechenov University) of Minzdrav of Russia, 119991, Moscow, Russia The young generation aged 16-24 years is the main demographic national reserve for coming decades. Hence, the purpose of the study is to investigate attitude of modern youth exemplified by students of medical university to establishing family, marriage and birth of children, and also their awareness about issues of reproductive health and training of couple to birth of healthy progeny considering modern approaches of personalized “4P Medicine”.The survey of medical students was carried out on the basis of sampling of 193 students in November 2019 to February 2020. The survey data was processed using software SPSS 21. The indices of descriptive and analytical statistics were calculated to analyze study results.The low awareness of medical students on issues of pregravid training and modern approaches of personalized «4P Medicine» was established. Despite the fact that significant number of students understand importance of improving their awareness of reproductive health and pregravid training from positions of “4P Medicine”, about quarter of all respondents never pondered about these issues. The majority of respondents lead healthy life-style and understand its importance for their health, including reproductive health. The students have positive attitudes to establishment of family and birth of children.It is necessary to improve awareness of medical students of reproductive health, pregravid training and main principles of personalized “4P Medicine”.

The integrated approach to diagnosis and dispensary monitoring of women with high risk for breast cancer, the active detection of combined pathology of endometrium are promising directions in prevention and timely diagnosis of breast and uterus malignant neoplasms. The study established that particular correction of measures of secondary prevention of breast cancer is needed, including formation of risk group and organization of dynamic monitoring of women with high risk of breast cancer development. The comprehensive examination of reproductive system organs, including evaluation of risk factors, combined use of mammography and sonography methods to examine mammary glands and condition of endometrium, can to increase accuracy of differential diagnosis and to avoid unneeded invasive interventions with mammary glands and early diagnosis of endometrial pathology.

The study substantiates possibility of using data retrieved from electronic medical records (EMR) for analyzing comorbidity under diseases of the eye and its adnexa. The purpose of the study is to analyze prevalence and evaluate risk of development of comorbidity in patients with ophthalmologic pathology, based on the data presented in EMR. The total number of patients included into comprised 12 120 individuals. The 653 diagnoses were established and 122 703 requests for medical care were registered. The calculation was applied concerning prevalence, comorbidity index, relative risk of comorbidity. The study established prevalence and level of relative risk of development of opportunistic diseases characteristic for senile cataract and glaucoma. The obtained data on comorbidity may testify in-depth mechanisms of interaction of diseases at cellular, protein or genetic levels. The understanding of mechanisms of interaction of main and concomitant diseases can result in development of new methods of diagnostic, treatment and prevention of diseases. Thus, establishment of glaucoma diagnosis can induce physician to look for possible presence or high probability of development of prostate neoplasm that implies periodic control of prostate-specific antigen. The presented results demonstrate how EMR data can be used to identify, estimate prevalence and risk of comorbidity and also reveals pathogenic mechanisms of interaction between primary and recurrent diseases that can be applied in clinical practice.

In quality of life research, it is very important to understand the concept and methodology of its implementation. The quality of life study should be organized in accordance with standard generally accepted requirements. In order to obtain comparable data and to apply it in clinical practice, standard quality of life assessment tools should be implemented. The questionnaires are common as the tools assessing quality of life. In the United States and Europe, as well as in Russia, special centers are organized to develop such questionnaires. There are General questionnaires that can be used to assess quality of life in case of various diseases and special questionnaires targeted to specific group of diseases. Currently, more than 400 special questionnaires are used in practice. In Russia, due to urgency of increasing propagation of socially significant non-communicable diseases, especially in elderly population, particular attention is focused on research in the area of quality of life in field of palliative medicine, assigned to alleviate suffering of incurable patient. Its main goal is to maintain optimal quality of life of patient.

International audience; Staphylococcus aureus hibernation promoting factor (SaHPF) is responsible for the formation of 100S ribosome dimers, which in turn help this pathogen to reduce energy spent under unfavorable conditions. Ribosome dimer formation strongly depends on the dimerization of the C-terminal domain of SaHPF (CTDSaHPF). In this study, we solved the crystal structure of CTDSaHPF at 1.6 Å resolution and obtained a precise arrangement of the dimer interface. Residues Phe160, Val162, Thr171, Ile173, Tyr175, Ile185 andThr187 in the dimer interface of SaHPF protein were mutated and the effects were analyzed for the formation of 100S disomes of ribosomes isolated from S. aureus. It was shown that substitution of any of single residues Phe160, Val162, Ile173, Tyr175 and Ile185 in the SaHPF homodimer interface abolished the ribosome dimerization in vitro.

Ribosome binding factor A (RbfA) is a 14.9 kDa adaptive protein of cold shock, which is important for bacterial growth at low temperatures. RbfA can bind to the free 30S ribosomal subunit and interacts with the 5'-terminal helix (helix I) of 16S rRNA. RbfA is important for the efficient processing of 16S rRNA and for the maturation (assembly) of 30S ribosomal subunits. Here we report backbone and side chains