4,353 results on '"A. Sánchez-Díaz"'
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2. Loss Allocation in Submarine Armored Three-core HVAC Power Cables
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del-Pino-López, Juan Carlos, Cruz-Romero, Pedro, and Sánchez-Díaz, Luis Carlos
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Electrical Engineering and Systems Science - Systems and Control - Abstract
Loss allocation of the three different components (conductor, sheaths and armor) of solidly bonded three-core separated lead-sheathed armored cables, frequently employed in offshore wind farms, is challenging due to the lack of accurate enough analytical expressions in the IEC standard. Also, loss allocation through experimental tests leads to inaccurate results since it is based on questionable assumptions. This paper improves both the IEC formulae and experimental methods by means of different analytical corrections in the conductor and sheath loss expressions. To this aim, an ad hoc application interface (Virtual Lab) based on 3D numerical simulations (finite element method) has been developed. This tool virtualizes and automates different test setups to emulate, in few seconds, the most employed experimental procedures in this type of cable. The analytical corrections have been derived from an in-depth analysis of a first set of 368 cables, ranging from 30 to 275 kV. The new loss expressions were successfully applied to a second set of 645 armored cables of quite diverse features (voltages from 10 to 275 kV, sections and dimensional parameters), hence bringing a general framework for any kind of three-core armored cable.
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- 2024
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3. Flexible Ansatz for N-body Perturbation Theory
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Miranda-Quintana, Ramón Alain, Kim, Taewon D., Lokhande, Rugwed A., Richer, M., Sánchez-Díaz, Gabriela, Gaikwad, Pratiksha B., and Ayers, Paul W.
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Physics - Chemical Physics - Abstract
We propose a new Perturbation Theory framework that can be used to help with the projective solution of the Schr\"odinger equation for arbitrary wavefunctions. This Flexible Ansatz for N-body Perturbation Theory (FANPT) is based on our previously proposed Flexible Ansatz for N-body Configuration Interaction (FANCI). We derive recursive FANPT expressions including arbitrary orders in the perturbation hierarchy. We show that the FANPT equations are well-behaved across a wide range of conditions, including static correlation-dominated configurations and highly non-linear wavefunctions.
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- 2023
4. Coupled Cluster-Inspired Geminal Wavefunctions
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Gaikwad, Pratiksha B., Kim, Taewon D., Richer, M., Lokhande, Rugwed A., Sánchez-Díaz, Gabriela, Limacher, Peter A., Ayers, Paul W., and Miranda-Quintana, Ramón Alain
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Physics - Chemical Physics - Abstract
Electron pairs have an illustrious history in chemistry, from powerful concepts to understanding structural stability and reactive changes, to the promise of serving as building blocks of quantitative descriptions of the electronic structure of complex molecules and materials. However, traditionally, two-electron wavefunctions (geminals), have not enjoyed the popularity and widespread use of the more standard single-particle methods. This has changed recently, with a renewed interest in the development of geminal wavefunctions as an alternative to describing strongly-correlated phenomena. Hence, there is a need to find geminal methods that are accurate, computationally-tractable, and do not demand significant input from the user (particularly, via cumbersome and often ill-behaved orbital optimization steps). Here we propose new families of geminal wavefunctions, inspired by the pair Coupled Cluster (pCCD) ansatz. We present a new hierarchy of two-electron wavefunctions that extend the one-reference orbital idea to other geminals. Moreover, we show how to incorporate single-like excitations in this framework, without leaving the quasiparticle picture. We explore the role of imposing seniority restrictions on these wavefunctions, and benchmark these new methods on model strongly-correlated systems.
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- 2023
5. A Comparison between Frame-based and Event-based Cameras for Flapping-Wing Robot Perception
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Tapia, Raul, Rodríguez-Gómez, Juan Pablo, Sanchez-Diaz, Juan Antonio, Gañán, Francisco Javier, Rodríguez, Iván Gutierrez, Luna-Santamaria, Javier, Dios, José Ramiro Martínez-de, and Ollero, Anibal
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Computer Science - Robotics - Abstract
Perception systems for ornithopters face severe challenges. The harsh vibrations and abrupt movements caused during flapping are prone to produce motion blur and strong lighting condition changes. Their strict restrictions in weight, size, and energy consumption also limit the type and number of sensors to mount onboard. Lightweight traditional cameras have become a standard off-the-shelf solution in many flapping-wing designs. However, bioinspired event cameras are a promising solution for ornithopter perception due to their microsecond temporal resolution, high dynamic range, and low power consumption. This paper presents an experimental comparison between frame-based and an event-based camera. Both technologies are analyzed considering the particular flapping-wing robot specifications and also experimentally analyzing the performance of well-known vision algorithms with data recorded onboard a flapping-wing robot. Our results suggest event cameras as the most suitable sensors for ornithopters. Nevertheless, they also evidence the open challenges for event-based vision on board flapping-wing robots.
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- 2023
6. Peptidylarginine deiminase 3 modulates response to neratinib in HER2 positive breast cancer
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Inés Romero-Pérez, Elena Díaz-Rodríguez, Laura Sánchez-Díaz, Juan Carlos Montero, and Atanasio Pandiella
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Neratinib is a tyrosine kinase inhibitor that is used for the therapy of patients with HER2+ breast tumors. However, despite its clinical benefit, resistance to the drug may arise. Here we have created cellular models of neratinib resistance to investigate the mechanisms underlying such resistance. Chronic neratinib exposure of BT474 human HER2+ breast cancer cells resulted in the selection of several clones resistant to the antiproliferative action of the drug. The clones were characterized biochemically and biologically using a variety of techniques. These clones retained HER2 levels similar to parental cells. Knockdown experiments showed that the neratinib-resistant clones retained oncogenic dependence on HER2. Moreover, the tyrosine phosphorylation status of BT474 and the resistant clones was equally sensitive to neratinib. Transcriptomic and Western analyses showed that peptidylarginine deiminase 3 was overexpressed in the three neratinib-resistant clones studied but was undetectable in BT474 cells. Experiments performed in the neratinib-resistant clones showed that reduction of PADI3 or inhibition of its function restored sensitivity to the antiproliferative action of neratinib. Moreover, overexpression of FLAG-tagged PADI3 in BT474 cells provoked resistance to the antiproliferative action of neratinib. Together, these results uncover a role of PADI3 in the regulation of sensitivity to neratinib in breast cancer cells overexpressing HER2 and open the possibility of using PADI3 inhibitors to fight resistance to neratinib.
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- 2024
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7. Antibiotic Nanoparticles-Loaded Wound Dressings Against Pseudomonas aeruginosa’s Skin Infection: A Systematic Review
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Quiñones-Vico MI, Ubago-Rodríguez A, Fernández-González A, Sanabria-de la Torre R, Sierra-Sánchez Á, Montero-Vilchez T, Sánchez-Díaz M, Arias JL, and Arias-Santiago S
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hydrogel ,nanoparticles ,p.aeruginosa ,skin infection ,wound dressing. ,Medicine (General) ,R5-920 - Abstract
María I Quiñones-Vico,1– 4,* Ana Ubago-Rodríguez,1– 3,* Ana Fernández-González,1– 3 Raquel Sanabria-de la Torre,2,5 Álvaro Sierra-Sánchez,1– 3,5 Trinidad Montero-Vilchez,2,6 Manuel Sánchez-Díaz,2,6 José L Arias,2,7,8 Salvador Arias-Santiago1– 4,6 1Cell Production and Tissue Engineering Unit, Virgen de las Nieves University Hospital, Granada, 18014, Spain; 2Instituto de Investigación Biosanitaria Granada ibs.GRANADA, Granada, 18014, Spain; 3Andalusian Network of Design and Translation of Advanced Therapies, Sevilla, 41092, Spain; 4Medicine Department, School of Medicine, University of Granada, Granada, 18016, Spain; 5Department of Biochemistry and Molecular Biology IIi and Immunology, School of Medicine, University of Granada, Granada, 18016, Spain; 6Dermatology Department, Virgen de las Nieves University Hospital, Granada, 18014, Spain; 7Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Granada, Granada, 18071, Spain; 8Institute of Biopathology and Regenerative Medicine (IBIMER), Center of Biomedical Research (CIBM), University of Granada, Granada, 18100, Spain*These authors contributed equally to this workCorrespondence: Ana Fernández-González, Email ana.fernandez.gonzalez@juntadeandalucia.esAbstract: Pseudomonas aeruginosa (P. aeruginosa) is a common nosocomial pathogen that can cause severe infections in critically ill patients. Due to its resistance to multiple drugs, it is challenging to treat, which can result in serious illness and death. Conventional treatments for infected wounds often involve the topical or systemic application of antibiotics, which can lead to systemic toxicity and the development of drug resistance. The combination of wound dressings that promote wound healing with nanoparticles (NPs) represents a revolutionary strategy for optimizing the safety and efficacy of antibiotics. This review assesses a systematic search to identify the latest approaches where the evaluation of wound dressings loaded with antibiotic NPs is conducted. The properties of NPs, the features of wound dressings, the antimicrobial activity and biocompatibility of the different strategies are analyzed. The results indicate that most research in this field is focused on dressings loaded with silver NPs (57.1%) or other inorganic materials (22.4%). Wound dressings loaded with polymeric NPs and carbon-based NPs represent 14.3% and 6.1% of the evaluated studies, respectively. Nevertheless, there are no clinical trials that have evaluated the efficacy of NPs-loaded wound dressings in patients. Further research is required to ensure the safety of these treatments and to translate the findings from the bench to the bedside. Keywords: hydrogel, skin infection, wound dressing, P. aeruginosa, nanoparticles
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- 2024
8. Access and Participation: The Use of Technologies as Tools for Inclusion by Spanish University Lecturers
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María Nieves Sánchez-Díaz, Beatriz Morgado, and Jane Seale
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Spanish face-to-face universities experience constant challenges that threaten the inclusion of students with disabilities. Adopting inclusive pedagogies can support universities to develop a more inclusive approach. This paper explores the extent to which the use of technology influences the inclusive pedagogies of Spanish university lecturers. In particular, we focus on how lecturers use technologies to promote student participation and accessibility in Spanish institution. A qualitative methodology involving semi-structured in-depth interviews with 42 Spanish face-to-face universities experience constant challenges that threaten the inclusion of students with disabilities. Adopting inclusive pedagogies can support universities to develop a more inclusive approach. This paper explores the extent to which the use of technology influences the inclusive pedagogies of Spanish university lecturers. In particular, we focus on how lecturers use technologies to promote student participation and accessibility in Spanish institution. A qualitative methodology involving semi-structured in-depth interviews with 42 Spanish university lecturers regarding their inclusive practices and use of technology was employed. The results contribute four fundamental findings: (a) Lecturers who practise inclusive pedagogy can be differentiated as proactive or reactive; (b) University lecturers place greater emphasis on the use of technology as a promoter of accessibility rather than as a tool to promote participation; (c) There is a disconnect between knowledge of universal design for learning and the use of the technologies; and (d) The full transformative potential of technologies to facilitate the inclusion of learners with disabilities is not being harnessed. All these results allow us to highlight some key points about the use of technological tools in the application of inclusive pedagogy in university classrooms.
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- 2024
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9. Teaching for All: Profile of Faculty Members Who Facilitate the Success and Inclusion of Students with Disability
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Beatriz Morgado and María Nieves Sánchez-Díaz
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The presence of students with disability in university classrooms is a current reality, which implies the need to develop inclusive teaching practices. The purpose of this study was to analyze the beliefs, attitudes, and characteristics of faculty members towards students with disability. A total of 42 participants were recruited since they had been previously selected as inclusive faculty members by students with disability. All participants taught at the faculties of education and belonged to 6 Spanish public universities. The biographic-narrative methodology was used, and the analysis of the data was defined by its narrative nature. The results indicate that the majority of faculty members are either from the social model of disability or from inclusive education approaches. They value their attitude towards students with disabilities as positive. Among their personal characteristics, empathy, closeness, involvement, and vocation are highlighted; and regarding their professional characteristics, they point out their commitment to their work, flexibility, the use of participative methodologies, or their role as a guide in the teaching and learning process, among others. These results have clear implications for teacher training plans with the aim of promoting inclusive pedagogy in higher education.
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- 2024
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10. Peptidylarginine deiminase 3 modulates response to neratinib in HER2 positive breast cancer
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Romero-Pérez, Inés, Díaz-Rodríguez, Elena, Sánchez-Díaz, Laura, Montero, Juan Carlos, and Pandiella, Atanasio
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- 2024
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11. Comparing patient-reported outcomes and lifestyle factors before and after the COVID-19 pandemic among Black and Hispanic breast cancer survivors in New Jersey
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Sánchez-Díaz, Carola T., Zeinomar, Nur, Iyer, Hari S., Perlstein, Marley, Gonzalez, Brian D., Hong, Chi-Chen, Bandera, Elisa V., and Qin, Bo
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- 2024
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12. Implementation feasibility of animal-assisted therapy in a pediatric intensive care unit: effectiveness on reduction of pain, fear, and anxiety
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López-Fernández, Eduardo, Palacios-Cuesta, Alba, Rodríguez-Martínez, Alicia, Olmedilla-Jodar, Marta, Fernández-Andrade, Rocío, Mediavilla-Fernández, Raquel, Sánchez-Díaz, Juan Ignacio, and Máximo-Bocanegra, Nuria
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- 2024
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13. 'Buen vivir es estar en paz y armonía con todo lo que nos rodea': estudio cualitativo sobre el buen vivir en el pueblo indígena Kankuamo de Colombia
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Catharina van der Boor, Giovanna Catalina Sánchez-Díaz, Luisa Juliana Guevara-Morales, Carlos Iván Molina-Bulla, Diana Marcela Agudelo-Ortiz, Adolfo José Montero-Villazón, Mario de Jesús Villazón-Rodríguez, Lilibeth Maestre-Arias, and Diego Mauricio Aponte-Canencio
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Pueblos Indígenas ,Salud Mental ,Autodeterminación ,Calidad de Vida ,Medicine ,Public aspects of medicine ,RA1-1270 - Abstract
Resumen: El pueblo Kankuamo es uno de los 102 pueblos originarios de Colombia, que se encuentran en el proceso de desarrollo de estrategias para la autogestión de salud individual y colectiva. Este artículo tiene como objetivo investigar, identificar y analizar, de forma colaborativa e intercultural, los factores que influyen en el bienestar del pueblo Kankuamo, utilizando el Enfoque de Capacidades propuesto por Amartya Sen. Con este fin, se llevaron a cabo tres grupos focales con la participación de 37 personas de las 15 comunidades del resguardo Kankuamo. Las transcripciones fueron analizadas mediante un análisis temático. De los grupos focales surgieron tres temas centrales para el bienestar de los Kankuamo: (i) armonía entre la naturaleza y los seres humanos, (ii) convivencia social y (iii) autodeterminación. Estos temas reflejan los principios y valores fundamentales que guían a la comunidad hacia el bienestar, la expansión de sus capacidades, la armonía y el desarrollo integral. Los resultados sugieren que los aspectos materiales desempeñan un papel secundario en el concepto de bienestar de la comunidad Kankuamo, y además confirman que es fundamental considerar una visión colectiva de capacidades, no solo individuales, en contextos indígenas. Estudios como este pueden contribuir al desarrollo de enfoques más contextualmente apropiados para evaluar y medir la calidad de vida y el bienestar de las comunidades indígenas, incluyendo el pueblo Kankuamo.
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- 2024
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14. Regularized Feature Selection Landscapes: An Empirical Study of Multimodality.
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Xavier F. C. Sánchez-Díaz, Corentin Masson, and Ole Jakob Mengshoel
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- 2024
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15. Estimating the Number of Local Optima in Multimodal Pseudo-Boolean Functions: Validation via Landscapes of Triangles.
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Xavier F. C. Sánchez-Díaz and Ole Jakob Mengshoel
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- 2024
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16. Regularized Feature Selection Landscapes: An Empirical Study of Multimodality
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Sánchez-Díaz, Xavier F. C., Masson, Corentin, Mengshoel, Ole Jakob, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Affenzeller, Michael, editor, Winkler, Stephan M., editor, Kononova, Anna V., editor, Trautmann, Heike, editor, Tušar, Tea, editor, Machado, Penousal, editor, and Bäck, Thomas, editor
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- 2024
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17. PyCI: A Python-scriptable library for arbitrary determinant CI.
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Richer, Michelle, Sánchez-Díaz, Gabriela, Martínez-González, Marco, Chuiko, Valerii, Kim, Taewon David, Tehrani, Alireza, Wang, Shuoyang, Gaikwad, Pratiksha B., de Moura, Carlos E. V., Masschelein, Cassandra, Miranda-Quintana, Ramón Alain, Gerolin, Augusto, Heidar-Zadeh, Farnaz, and Ayers, Paul W.
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DENSITY matrices , *QUANTUM chemistry , *COMPUTER software development , *NONLINEAR functions , *C++ - Abstract
PyCI is a free and open-source Python library for setting up and running arbitrary determinant-driven configuration interaction (CI) computations, as well as their generalizations to cases where the coefficients of the determinant are nonlinear functions of optimizable parameters. PyCI also includes functionality for computing the residual correlation energy, along with the ability to compute spin-polarized one- and two-electron (transition) reduced density matrices. PyCI was originally intended to replace the ab initio quantum chemistry functionality in the HORTON library but emerged as a standalone research tool, primarily intended to aid in method development, while maintaining high performance so that it is suitable for practical calculations. To this end, PyCI is written in Python, adopting principles of modern software development, including comprehensive documentation, extensive testing, continuous integration/delivery protocols, and package management. Computationally intensive steps, notably operations related to generating Slater determinants and computing their expectation values, are delegated to low-level C++ code. This article marks the official release of the PyCI library, showcasing its functionality and scope. [ABSTRACT FROM AUTHOR]
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- 2024
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18. ModelHamiltonian: A Python-scriptable library for generating 0-, 1-, and 2-electron integrals.
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Chuiko, Valerii, Richards, Addison D. S., Sánchez-Díaz, Gabriela, Martínez-González, Marco, Sanchez, Wesley, B. Da Rosa, Giovanni, Richer, Michelle, Zhao, Yilin, Adams, William, Johnson, Paul A., Heidar-Zadeh, Farnaz, and Ayers, Paul W.
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GRAPHICAL user interfaces ,ISING model ,LIBRARY design & construction ,HEISENBERG model ,QUANTUM chemistry ,PYTHON programming language - Abstract
ModelHamiltonian is a free, open source, and cross-platform Python library designed to express model Hamiltonians, including spin-based Hamiltonians (Heisenberg and Ising models) and occupation-based Hamiltonians (Pariser–Parr–Pople, Hubbard, and Hückel models) in terms of 1- and 2-electron integrals, so that these systems can be easily treated by traditional quantum chemistry software programs. ModelHamiltonian was originally intended to facilitate the testing of new electronic structure methods using HORTON but emerged as a stand-alone research tool that we recognize has wide utility, even in an educational context. ModelHamiltonian is written in Python and adheres to modern principles of software development, including comprehensive documentation, extensive testing, continuous integration/delivery protocols, and package management. While we anticipate that most users will use ModelHamiltonian as a Python library, we include a graphical user interface so that models can be built without programming, based on connectivity/parameters inferred from, for example, a SMILES string. We also include an interface to ChatGPT so that users can specify a Hamiltonian in plain language (without learning ModelHamiltonian's vocabulary and syntax). This article marks the official release of the ModelHamiltonian library, showcasing its functionality and scope. [ABSTRACT FROM AUTHOR]
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- 2024
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19. Calidad de vida profesional en dermatología: impacto de la pandemia y propuestas de mejora
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A. Soto-Moreno, C. Ureña-Paniego, T. Montero-Vílchez, M. Sánchez-Díaz, P. Díaz-Calvillo, J.A. Rodríguez-Pozo, A. Molina-Leyva, A. Martínez-López, A. Buendía-Eisman, and S. Arias-Santiago
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Quality of life ,Work satisfaction ,Dermatology ,COVID-19 ,RL1-803 ,Internal medicine ,RC31-1245 - Abstract
Resumen: Antecedentes y objetivo: La calidad de vida profesional se define como el bienestar derivado del equilibrio entre las exigencias del ámbito laboral y los recursos para afrontarlas, el deterioro de la calidad de vida profesional puede contribuir en el síndrome de burnout o del profesional quemado. El objetivo de este estudio consiste en evaluar mediante cuestionario validado la calidad de vida profesional de los dermatólogos españoles. Material y métodos: Se diseñó un estudio transversal que incluyó dermatólogos españoles que respondieran a un formulario autoadministrado enviado a través de aplicaciones de mensajería online. El formulario incluyó datos sociodemográficos, 3 preguntas de respuestas abiertas y el Cuestionario de Calidad de Vida Profesional (CVP-35). Resultados: Se incluyó a 106 participantes en este estudio, siendo un 58% (62/106) mujeres. La edad media fue de 41 años (intervalo de confianza [IC] del 95%: 43,3-38,8). Las puntuaciones para el dominio «carga de trabajo» de CVP-35 fueron superiores en las mujeres (p = 0,02) y en los jefes de servicio (p = 0,005). La presión asistencial fue el tema tratado con más frecuencia como factor limitante de la calidad de vida laboral, y el principal cambio identificado tras la pandemia de COVID-19. Conclusiones: En nuestro estudio las mujeres refirieron una mayor carga de trabajo. El incremento de carga asistencial y de trabajo a distancia fueron los principales cambios por la pandemia de COVID-19. La presión asistencial es una gran limitante de la calidad de vida profesional de nuestros compañeros, reducirla mejoraría la satisfacción diaria y la calidad asistencial. Abstract: Background and objective: Quality of professional life (QPL) is defined as a sense of well-being derived from a balance between the challenges of work and the resources available to deal with them. Impaired QPL can contribute to burnout. The aim of this study was to evaluate QPL in Spanish dermatologists using a validated questionnaire. Material and methods: We designed a cross-sectional study in which Spanish dermatologists were invited to complete an online questionnaire sent out by messaging applications. The dermatologists were asked to provide sociodemographic information, answer 3 open questions, and complete the 35-item Spanish QPL questionnaire (Spanish abbreviation, CVP-35). Results: We analyzed the information submitted by 106 dermatologists (62 women, 58%) with a mean age of 41 years (95% CI, 43.3-38.8 years). Women and department heads scored significantly higher in the workload domain of the questionnaire (P = .02 and P = .005, respectively). A heavy caseload was mentioned as the main factor contributing to impaired QPL and the main change in the wake of the COVID-19 pandemic. Conclusions: Female dermatologists reported heavier workloads. Heavy caseloads and more remote work were the main changes identified after the COVID-19 pandemic. Heavy caseloads have a significant impact on the QPL of dermatologists in Spain. Reducing caseloads would improve general job satisfaction and quality of care provision.
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- 2024
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20. Impact of COVID-19 Pandemic on Cutaneous Squamous Cell Carcinoma: A Single-Centre Study of Epidemiologic, Clinic and Histopathological Factors
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P. Díaz-Calvillo, M. Sánchez-Díaz, J.Á. Rodríguez-Pozo, V. Martínez-Ruiz, A. Martínez-López, and S. Arias-Santiago
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COVID-19 ,Cáncer de piel ,Carcinoma de células escamosas ,Dermatology ,RL1-803 ,Internal medicine ,RC31-1245 - Abstract
Background: The COVID-19 pandemic may have adversely affected the early diagnosis of skin cancer. Objective: To compare epidemiological, clinical and histopathological characteristics in patients undergoing cutaneous squamous cell carcinoma (SCC) surgery before and after the beginning of the pandemic. Material & methods: We conducted a cross-sectional study including two case series: (1) patients operated on for SCC in the year after the first state of alarm in Spain (15 March 2020), and (2) patients with SCC operated on in the previous year. Epidemiological, clinical and histopathological variables, tumour stage and risk grade were collected. Results: 248 patients were included (127 undergoing surgery before the pandemic and 121 after the pandemic). After the beginning of the pandemic, the percentage of high-risk SCC significantly increased from 35.3% to 46.2% (p = 0.011). However, no significant differences were found in thickness, perineural invasion or metastases. Conclusions: Although there has not been a significant reduction in the number of SCC operated on after the pandemic, there has been a significant increase in high-risk SCC. All this could lead to an increase in skin cancer mortality in the future. Resumen: Antecedentes: La pandemia de COVID-19 ha podido afectar negativamente el diagnóstico precoz del cáncer de piel. Objetivo: Comparar las características epidemiológicas, clínicas e histopatológicas en los pacientes intervenidos de carcinoma de células escamosas (CCE) cutáneo antes de la pandemia y después del inicio de la pandemia. Material y métodos: Se diseñó un estudio transversal que incluía 2 series de pacientes: 1) pacientes intervenidos de CCE el año posterior a la declaración del confinamiento general en España (15 de marzo de 2020), y 2) pacientes intervenidos de CCE el año previo. Se recogieron variables epidemiológicas, clínicas e histopatológicas, así como el estadio tumoral y el grado de riesgo. Resultados: Se incluyeron 248 pacientes (127 intervenidos antes de la pandemia y 121 intervenidos después de la pandemia). Tras el inicio de la pandemia, el porcentaje de CCE de alto riesgo aumentó significativamente de 32,3 a 45,5% (p = 0,011). No obstante, no se encontraron diferencias significativas en el grosor tumoral, la invasión perineural o la presencia de metástasis. Conclusiones: Aunque no se produjo una reducción significativa en el número de CCE intervenidos después de la pandemia, ha habido un incremento significativo en los CCE de alto riesgo. Todo ello puede conllevar un incremento en la mortalidad por cáncer de piel en el futuro.
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- 2024
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21. Condicionantes de acceso a nuevos medicamentos dermatológicos en España: resultados del proyecto EQUIDAD
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M. Sánchez-Díaz, Á. Flórez, M. Ara-Martín, S. Arias-Santiago, R. Botella-Estrada, J. Cañueto, G. Carretero-Hernández, P. Coto-Segura, E. de Eusebio-Murillo, F.J. García-Latasa de Araníbar, V. García-Patos Briones, J. Gardeazabal García, C. Gómez-Fernández, S. Hernández-Ostiz, R. Izu Belloso, A. López-Ávila, P. Manchado López, A. Martín-Santiago, I. Martinez de Espronceda Ezquerro, A. Mateu-Puchades, P. Mercader-García, J. Notario Rosa, L. Palacio Aller, C. Pérez-Hortet, L. Quintana-Castanedo, R. Rivera, V. Rocamora Duran, I.M. Rodríguez-Nevado, R. Ruiz-Villaverde, J. Suárez, L. Trasobares-Marugán, C. Vizán-de Uña, I. Yanguas, A. Zulaica-Garate, I. García-Doval, M.Á. Descalzo, M. Grau-Pérez, and J.M. Carrascosa-Carrillo
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Equity ,Drugs ,Psoriasis ,Atopic dermatitis ,Oncology ,Spain ,Dermatology ,RL1-803 ,Internal medicine ,RC31-1245 - Abstract
Resumen: Antecedentes: En España, aunque el Ministerio de Sanidad elabora el informe de posicionamiento terapéutico (IPT) y las condiciones de reembolso de los fármacos, las Comunidades Autónomas (CC. AA.) gestionan los servicios de salud y deciden sobre las condiciones de prescripción en su ámbito territorial. El objetivo del estudio EQUIDAD fue describir los condicionantes para la prescripción de los nuevos fármacos en Dermatología en las CC. AA. y sus posibles diferencias. Material y métodos: Estudio transversal realizado en abril-mayo del 2023. Dos dermatólogos con responsabilidades directivas de cada Comunidad Autónoma (C. A.) informaron sobre los condicionantes autonómicos y locales en la prescripción de los fármacos cuyo IPT para el tratamiento de enfermedades dermatológicas fue publicado en los años 2016-2022. Los datos fueron recogidos mediante un cuestionario online. Resultados: Un total de 33 investigadores de 17 CC. AA. participaron en el estudio. Se observaron inequidades entre CC. AA. para el acceso a los nuevos fármacos. Existieron condicionantes autonómicos adicionales al IPT en psoriasis en el 64,7% de las CC. AA., siendo este porcentaje menor en dermatitis atópica (35,3%) o melanoma (11,8%). El más frecuente fue el requisito de un orden de prescripción previo para el uso del fármaco. En algunas CC. AA. se detectaron además variaciones y condicionantes locales (diferencias entre centros de una misma C. A.). Conclusiones: Existe una multiplicidad de criterios tanto a nivel autonómico como local que añade restricciones adicionales a las establecidas por los IPT y que plantean una situación de inequidad entre los pacientes y los profesionales de las diferentes CC. AA. en el acceso a los nuevos fármacos. Abstract: Background: Although the Spanish Ministry of Health prepares national therapeutic positioning reports (TPRs) and drug reimbursement policies, each of the country's 17 autonomous communities (ACs) is responsible for health care services and prescription requirements in its territory. The aim of the EQUIDAD study was to describe and explore potential differences in prescription requirements for new dermatology drugs across the autonomous communities. Material and methods: Cross-sectional study conducted in April and May, 2023. Two dermatologists with management responsibilities from each autonomous community reported on territorial and more local prescription requirements for drugs covered by national TPRs issued between 2016 and 2022. Results: Thirty-three researchers from 17 autonomous communities participated. The data submitted revealed between-community inequities in access to new drugs. Overall, 64.7% of the regions imposed additional prescription requirements to those mentioned in the TPRs for psoriasis. This percentage was lower for atopic dermatitis (35.3%) and melanoma (11.8%). The most common requirement for accessing a new drug was a previous prescription for another drug. Differences and additional requirements were also detected atthe local level (i.e., differences between hospitals within the same autonomous community). Conclusions: Spain's autonomous communities have multiple regional and local prescription requirements that are not aligned with national TPR recommendations. These differences result in inequitable access to new drugs for both patients and practitioners across Spain.
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- 2024
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22. Corrigendum to 'Propensity-Score Analysis Reveals that Sex is Not a Prognostic Factor for Mortality in Intensive Care Unit-Admitted Patients with Septic Bacteremia' [International Journal of Infectious Diseases, volume 110 (2021) pages 36-44]
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Manuel Ponce-Alonso, Borja M. Fernández-Félix, Ana Halperin, Mario Rodríguez-Domínguez, Ana M. Sánchez-Díaz, Rafael Cantón, Alfonso Muriel, Javier Zamora, and Rosa del Campo
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Infectious and parasitic diseases ,RC109-216 - Published
- 2024
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23. The limited impact of free college policies
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Ferreyra, Maria Marta, Garriga, Carlos, Martin-Ocampo, Juan David, and Sanchez-Diaz, Angelica Maria
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- 2024
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24. The value added of short-cycle higher education programs to student outcomes: Evidence from Colombia
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Dinarte-Diaz, Lelys, Ferreyra, Maria Marta, Melguizo, Tatiana, and Sanchez-Diaz, Angelica
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- 2024
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25. Are accessory spleen screening and resection in refractory immune cytopenia an effective strategy or a waste of resources?
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Rodríguez-Rodríguez, Sergio, Álvarez-Blanco, José Miguel, Sánchez-Díaz, Susana, Rangel-Patiño, Juan, Sierra-Salazar, Ana, Apodaca-Chávez, Elia, and Demichelis-Gómez, Roberta
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- 2023
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26. Association of Physical Activity and/or Diet with Sleep Quality and Duration in Adolescents: A Scoping Review
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Jon Cruz, Iñaki Llodio, Aitor Iturricastillo, Javier Yanci, Silvia Sánchez-Díaz, and Estibaliz Romaratezabala
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exercise ,sport ,diet ,nutrition ,sleep ,insomnia ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Background: Sleep is essential for health, especially during adolescence. However, most adolescents do not obtain the recommended 8 to 10 h of sleep, and their health is significantly affected. While both physical activity (PA) and diet have been shown to help improve the sleep quality and duration, the combined association of these two factors with sleep has yet to be analysed. Objectives: Therefore, the main objective of this study was to assess the evidence on the combined association of PA and diet with the quality and duration of sleep in adolescents. Secondary objectives were to analyse the evidence on the single association of PA with the quality and duration of sleep in adolescents and to analyse the single association of diet with the quality and duration of sleep in adolescents. Methods: To this end, a scoping review was conducted with a structured search in four online databases (PubMed, Scopus, Web of Science and ERIC). Results: The findings suggest that the amount of PA (time/week) and healthy dietary patterns, characterised by meal regularity and high consumption of fruits and vegetables, favour a better quality and a longer duration of sleep. Conversely, less weekly PA and the intake of less healthy foods, such as ultra-processed foods, are associated with decreasing the sleep quality and duration. Conclusions: In conclusion, the results underscore the importance of considering PA and diet as an appropriate approach to investigating sleep quality and duration in adolescents. Studies analysing the interplay between PA, diet and sleep in adolescents are scarce.
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- 2024
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27. GBasis: A Python library for evaluating functions, functionals, and integrals expressed with Gaussian basis functions.
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Kim, Taewon David, Pujal, Leila, Richer, Michelle, van Zyl, Maximilian, Martínez-González, Marco, Tehrani, Alireza, Chuiko, Valerii, Sánchez-Díaz, Gabriela, Sanchez, Wesley, Adams, William, Huang, Xiaomin, Kelly, Braden D., Vöhringer-Martinez, Esteban, Verstraelen, Toon, Heidar-Zadeh, Farnaz, and Ayers, Paul W.
- Abstract
GBasis is a free and open-source Python library for molecular property computations based on Gaussian basis functions in quantum chemistry. Specifically, GBasis allows one to evaluate functions expanded in Gaussian basis functions (including molecular orbitals, electron density, and reduced density matrices) and to compute functionals of Gaussian basis functions (overlap integrals, one-electron integrals, and two-electron integrals). Unique features of GBasis include supporting evaluation and analytical integration of arbitrary-order derivatives of the density (matrices), computation of a broad range of (screened) Coulomb interactions, and evaluation of overlap integrals of arbitrary numbers of Gaussians in arbitrarily high dimensions. For circumstances where the flexibility of GBasis is less important than high performance, a seamless Python interface to the Libcint C package is provided. GBasis is designed to be easy to use, maintain, and extend following many standards of sustainable software development, including code-quality assurance through continuous integration protocols, extensive testing, comprehensive documentation, up-to-date package management, and continuous delivery. This article marks the official release of the GBasis library, outlining its features, examples, and development. [ABSTRACT FROM AUTHOR]
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- 2024
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28. Shortest-length and coarsest-granularity constructs vs. reducts: An experimental evaluation
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Lazo-Cortés, Manuel S., Sanchez-Diaz, Guillermo, and Almanza Ortega, Nelva N.
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- 2024
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29. Neighborhood Archetypes and Cardiovascular Health in Black Breast Cancer Survivors
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Sánchez-Díaz, Carola T., Babel, Riddhi A., Iyer, Hari S., Goldman, Noreen, Zeinomar, Nur, Rundle, Andrew G., Omene, Coral O., Pawlish, Karen S., Ambrosone, Christine B., Demissie, Kitaw, Hong, Chi-Chen, Lovasi, Gina S., Bandera, Elisa V., and Qin, Bo
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- 2024
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30. Effects of freight curbside management on sustainable cities: Evidence and paths forward
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Castrellon, Juan Pablo and Sanchez-Diaz, Ivan
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- 2024
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31. Caracterización clínico-epidemiológica de los pacientes con COVID persistente en México
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Luis Del Carpio-Orantes, Daniela Trelles-Hernández, Sergio García-Méndez, Jesús S. Sánchez-Díaz, Andrés Aguilar-Silva, and Ener R. López-Vargas
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COVID persistente. Disautonomías. Fatiga. ,Public aspects of medicine ,RA1-1270 ,Internal medicine ,RC31-1245 - Abstract
Antecedentes: El COVID persistente se define como la persistencia de síntomas de COVID-19 después de cuatro semanas de cursar con un cuadro agudo, según la definición más reciente de los Centers for Disease Control and Prevention. Se estima que existen 65 millones de personas afectadas por esta entidad, aunque algunos reportes indican 200 millones. Objetivo: Caracterizar a la población afectada por COVID persistente en México. Material y métodos: Se incluyeron pacientes mayores de 18 años que consintieron responder a una encuesta en línea y que cumplían los criterios de COVID persistente. Resultados: Se incluyeron los datos de 203 sujetos. Se identificó que 138 (68.0 %) contestaron ser del sexo femenino, con una media de edad de 41.8 años; 29.6 % presentó enfermedad grave y 70.4 %, enfermedad leve a moderada; 89.7 % había recibido vacunas previas para COVID-19: 6.9 %, una dosis; 31.5 %, dos dosis; y 51.2 %, tres o más dosis. Los principales factores de riesgo fueron diabetes, sobrepeso u obesidad e hipertensión arterial sistémica. El principal síntoma reportado fue fatiga, seguido de otras manifestaciones neuropsiquiátricas. Conclusión: Es importante caracterizar a la población para generar protocolos de diagnóstico y tratamiento.
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- 2024
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32. El cómic como historia de vida de personas sordas: una propuesta pedagógica visual
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Karina Muñoz-Vilugrón, Jéssica Aliaga-Rojas, and Gabriel Sánchez-Díaz
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cómic ,sordo ,lectura ,escritura ,Education ,Education (General) ,L7-991 - Abstract
La orientación para profesionales que se vinculan con la educación de las personas sordas debe considerar especialistas competentes en la lengua de señas y el diseño de materiales visuales. Por lo tanto, este artículo de investigación tiene como objetivo explorar el valor de las historias de personas sordas líderes para la construcción de un prototipo pedagógico visual (PPV) que contribuya al desarrollo de la lectura y la escritura en educación primaria. La investigación se aborda desde un enfoque cualitativo y considera las epistemologías de los sordos con un diseño narrativo. De esta forma, se recopilaron historias de vida por medio de entrevistas semiestructuradas a 6 adultos líderes sordos de 3 ciudades de Chile. La información fue codificada con el software Atlas ti. La categoría central es el prototipo pedagógico visual, que engloba 4 subcategorías: identidad sorda, comunidad sorda, comunicación y aprendizaje. Estas conforman el sustento para el diseño del cómic Cata Plum-Cata Plam, cuya historia pone de relieve elementos desde las experiencias lingüístico-culturales de los participantes con su entorno familiar y escolar, que visibilizan la importancia de la lengua de señas chilena, así como la lectura y escritura a través de un material significativo.
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- 2024
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33. [Artículo traducido] Impacto de la pandemia COVID-19 en el carcinoma de células escamosas cutáneo: un estudio unicéntrico de los factores epidemiológicos, clínicos e histopatológicos
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P. Díaz-Calvillo, M. Sánchez-Díaz, J.Á. Rodríguez-Pozo, V. Martínez-Ruiz, A. Martínez-López, and S. Arias-Santiago
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COVID-19 ,Skin cancer ,Squamous cell carcinoma ,Dermatology ,RL1-803 ,Internal medicine ,RC31-1245 - Abstract
Resumen: Antecedentes: La pandemia de COVID-19 ha podido afectar negativamente el diagnóstico precoz del cáncer de piel. Objetivo: Comparar las características epidemiológicas, clínicas e histopatológicas en los pacientes intervenidos de carcinoma de células escamosas (CCE) cutáneo antes de la pandemia y después del inicio de la pandemia. Material y métodos: Se diseñó un estudio transversal que incluía 2 series de pacientes: 1) pacientes intervenidos de CCE el año posterior a la declaración del confinamiento general en España (15 de marzo de 2020), y 2) pacientes intervenidos de CCE el año previo. Se recogieron variables epidemiológicas, clínicas e histopatológicas, así como el estadio tumoral y el grado de riesgo. Resultados: Se incluyeron 248 pacientes (127 intervenidos antes de la pandemia y 121 intervenidos después de la pandemia). Tras el inicio de la pandemia, el porcentaje de CCE de alto riesgo aumentó significativamente de 32,3 a 45,5% (p = 0,011). No obstante, no se encontraron diferencias significativas en el grosor tumoral, la invasión perineural o la presencia de metástasis. Conclusiones: Aunque no se produjo una reducción significativa en el número de CCE intervenidos después de la pandemia, ha habido un incremento significativo en los CCE de alto riesgo. Todo ello puede conllevar un incremento en la mortalidad por cáncer de piel en el futuro. Abstract: Background: The COVID-19 pandemic may have adversely affected the early diagnosis of skin cancer. Objective: To compare epidemiological, clinical and histopathological characteristics in patients undergoing cutaneous squamous cell carcinoma (SCC) surgery before and after the beginning of the pandemic. Material & methods: We conducted a cross-sectional study including two case series: (1) patients operated on for SCC in the year after the first state of alarm in Spain (15 March 2020), and (2) patients with SCC operated on in the previous year. Epidemiological, clinical and histopathological variables, tumour stage and risk grade were collected. Results: 248 patients were included (127 undergoing surgery before the pandemic and 121 after the pandemic). After the beginning of the pandemic, the percentage of high-risk SCC significantly increased from 35.3% to 46.2% (p = 0.011). However, no significant differences were found in thickness, perineural invasion or metastases. Conclusions: Although there has not been a significant reduction in the number of SCC operated on after the pandemic, there has been a significant increase in high-risk SCC. All this could lead to an increase in skin cancer mortality in the future.
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- 2024
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34. [Translated article] Quality of Professional Life Among Dermatologists: Impact of the COVID-19 Pandemic and Suggestions for Improvement
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A. Soto-Moreno, C. Ureña-Paniego, T. Montero-Vílchez, M. Sánchez-Díaz, P. Díaz-Calvillo, J.A. Rodríguez-Pozo, A. Molina-Leyva, A. Martínez-López, A. Buendía-Eisman, and S. Arias-Santiago
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Calidad de vida ,Satisfacción laboral ,Dermatología ,COVID-19 ,Dermatology ,RL1-803 ,Internal medicine ,RC31-1245 - Abstract
Background and objective: Quality of professional life (QPL) is defined as a sense of well-being derived from a balance between the challenges of work and the resources available to deal with them. Impaired QPL can contribute to burnout. The aim of this study was to evaluate QPL in Spanish dermatologists using a validated questionnaire. Material and methods: We designed a cross-sectional study in which Spanish dermatologists were invited to complete an online questionnaire sent out by messaging applications. The dermatologists were asked to provide sociodemographic information, answer 3 open questions, and complete the 35-item Spanish QPL questionnaire (Spanish abbreviation, CVP-35). Results: We analyzed the information submitted by 106 dermatologists (62 women, 58%) with a mean age of 41 years (95% CI, 43.3-38.8 years). Women and department heads scored significantly higher in the workload domain of the questionnaire (P = .02 and P = .005, respectively). A heavy caseload was mentioned as the main factor contributing to impaired QPL and the main change in the wake of the COVID-19 pandemic. Conclusions: Female dermatologists reported heavier workloads. Heavy caseloads and more remote work were the main changes identified after the COVID-19 pandemic. Heavy caseloads have a significant impact on the QPL of dermatologists in Spain. Reducing caseloads would improve general job satisfaction and quality of care provision. Resumen: Antecedentes y objetivo: La calidad de vida profesional se define como el bienestar derivado del equilibrio entre las exigencias del ámbito laboral y los recursos para afrontarlas, el deterioro de la calidad de vida profesional puede contribuir en el síndrome de burnout o del profesional quemado. El objetivo de este estudio consiste en evaluar mediante cuestionario validado la calidad de vida profesional de los dermatólogos españoles. Material y métodos: Se diseñó un estudio transversal que incluyó dermatólogos españoles que respondieran a un formulario autoadministrado enviado a través de aplicaciones de mensajería online. El formulario incluyó datos sociodemográficos, 3 preguntas de respuestas abiertas y el Cuestionario de Calidad de Vida Profesional (CVP-35). Resultados: Se incluyó a 106 participantes en este estudio, siendo un 58% (62/106) mujeres. La edad media fue de 41 años (intervalo de confianza [IC] del 95%: 43,3-38,8). Las puntuaciones para el dominio «carga de trabajo» de CVP-35 fueron superiores en las mujeres (p = 0,02) y en los jefes de servicio (p = 0,005). La presión asistencial fue el tema tratado con más frecuencia como factor limitante de la calidad de vida laboral, y el principal cambio identificado tras la pandemia de COVID-19. Conclusiones: En nuestro estudio las mujeres refirieron una mayor carga de trabajo. El incremento de carga asistencial y de trabajo a distancia fueron los principales cambios por la pandemia de COVID-19. La presión asistencial es una gran limitante de la calidad de vida profesional de nuestros compañeros, reducirla mejoraría la satisfacción diaria y la calidad asistencial.
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- 2024
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35. [Translated article] Requirements for Accessing New Dermatology Drugs in Spain: Results of the EQUIDAD Study
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M. Sánchez-Díaz, Á. Flórez, M. Ara-Martín, S. Arias-Santiago, R. Botella-Estrada, J. Cañueto, G. Carretero-Hernández, P. Coto-Segura, E. de Eusebio-Murillo, F.J. García-Latasa de Araníbar, V. García-Patos Briones, J. Gardeazabal García, C. Gómez-Fernández, S. Hernández-Ostiz, R. Izu Belloso, A. López-Ávila, P. Manchado López, A. Martín-Santiago, I. Martinez de Espronceda Ezquerro, A. Mateu-Puchades, P. Mercader-García, J. Notario Rosa, L. Palacio Aller, C. Pérez-Hortet, L. Quintana-Castanedo, R. Rivera, V. Rocamora Duran, I.M. Rodríguez-Nevado, R. Ruiz-Villaverde, J. Suárez, L. Trasobares-Marugán, C. Vizán-de Uña, I. Yanguas, A. Zulaica-Garate, I. García-Doval, M.Á. Descalzo, M. Grau-Pérez, and J.M. Carrascosa-Carrillo
- Subjects
Equidad ,Fármacos ,Psoriasis ,Dermatitis atópica ,Oncología ,España ,Dermatology ,RL1-803 ,Internal medicine ,RC31-1245 - Abstract
Background: Although the Spanish Ministry of Health prepares national therapeutic positioning reports (TPRs) and drug reimbursement policies, each of the country's 17 autonomous communities (ACs) is responsible for health care services and prescription requirements in its territory. The aim of the EQUIDAD study was to describe and explore potential differences in prescription requirements for new dermatology drugs across the autonomous communities. Material and methods: Cross-sectional study conducted in April and May, 2023. Two dermatologists with management responsibilities from each autonomous community reported on territorial and more local prescription requirements for drugs covered by national TPRs issued between 2016 and 2022. Results: Thirty-three researchers from 17 autonomous communities participated. The data submitted revealed between-community inequities in access to new drugs. Overall, 64.7% of the regions imposed additional prescription requirements to those mentioned in the TPRs for psoriasis. This percentage was lower for atopic dermatitis (35.3%) and melanoma (11.8%). The most common requirement for accessing a new drug was a previous prescription for another drug. Differences and additional requirements were also detected at the local level (i.e., differences between hospitals within the same autonomous community). Conclusions: Spain's autonomous communities have multiple regional and local prescription requirements that are not aligned with national TPR recommendations. These differences result in inequitable access to new drugs for both patients and practitioners across Spain. Resumen: Antecedentes: En España, aunque el Ministerio de Sanidad elabora el informe de posicionamiento terapéutico (IPT) y las condiciones de reembolso de los fármacos, las Comunidades Autónomas (CC. AA.) gestionan los servicios de salud y deciden sobre las condiciones de prescripción en su ámbito territorial. El objetivo del estudio EQUIDAD fue describir los condicionantes para la prescripción de los nuevos fármacos en Dermatología en las CC. AA. y sus posibles diferencias. Material y métodos: Estudio transversal realizado en abril-mayo del 2023. Dos dermatólogos con responsabilidades directivas de cada Comunidad Autónoma (C. A.) informaron sobre los condicionantes autonómicos y locales en la prescripción de los fármacos cuyo IPT para el tratamiento de enfermedades dermatológicas fue publicado en los años 2016-2022. Los datos fueron recogidos mediante un cuestionario online. Resultados: Un total de 33 investigadores de 17 CC. AA. participaron en el estudio. Se observaron inequidades entre CC. AA. para el acceso a los nuevos fármacos. Existieron condicionantes autonómicos adicionales al IPT en psoriasis en el 64,7% de las CC. AA., siendo este porcentaje menor en dermatitis atópica (35,3%) o melanoma (11,8%). El más frecuente fue el requisito de un orden de prescripción previo para el uso del fármaco. En algunas CC. AA. se detectaron además variaciones y condicionantes locales (diferencias entre centros de una misma C. A.). Conclusiones: Existe una multiplicidad de criterios tanto a nivel autonómico como local que añade restricciones adicionales a las establecidas por los IPT y que plantean una situación de inequidad entre los pacientes y los profesionales de las diferentes CC. AA. en el acceso a los nuevos fármacos.
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- 2024
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36. A long-term survey of Serratia spp. bloodstream infections revealed an increase of antimicrobial resistance involving adult population
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Blanca Pérez-Viso, Marta Hernández-García, Concepción M. Rodríguez, Miguel D. Fernández-de-Bobadilla, María Isabel Serrano-Tomás, Ana María Sánchez-Díaz, José Avendaño-Ortiz, Teresa M. Coque, Patricia Ruiz-Garbajosa, Rosa del Campo, and Rafael Cantón
- Subjects
bacteremia ,bloodstream infections ,Serratia spp. ,retrospective study ,whole genome sequencing ,Microbiology ,QR1-502 - Abstract
ABSTRACTSerratia spp. is a well-recognized pathogen in neonates; however, limited data are available in adults. We studied microbiological and clinical characteristics of Serratia spp. causing bloodstream infections (BSI) in our institution (January 2005–July 2020). Overall, 141 BSI episodes affecting 139 patients were identified and medical records reviewed. Antimicrobial susceptibility was recovered from our informatics system and 118 isolates from 116 patients were available for further microbiological studies. Whole genome sequencing (WGS) was completed in 107 isolates. Incidence of Serratia BSI was 0.3/1000 overall admissions (range 0.12–0.60), with maximum prevalence (27 episodes, 19.1%) during 2017–2018. Relevant patients’ clinical characteristics were 71.9% ≥60 years (n = 100), with high comorbidity rates (49%, ≥2), 23 (74.2%) of them died within 1 month of the BSI episode. WGS identified all isolates as Serratia marcescens when Kraken bioinformatics taxonomic tool was used despite some which were identified as Serratia nematodiphila (32/118) or Serratia ureilytica (5/118) by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Nevertheless, when using MASH distance, Serratia nevei (63/107), S. ureilytica (38/107), and S. marcescens (6/107) were assigned. Carbapenemase (blaVIM-1) and extended-spectrum β-lactases (ESBL) (blaSHV-12) genes were found in seven and three isolates, respectively, one of them expressing both genes. The worldwide-disseminated IncL/M scaffold plasmid was identified in six VIM producers. Four genotypes were established based on their virulence factors and resistome. Serratia spp. emerged as a relevant nosocomial pathogen causing BSI in elderly patients in our hospital, particularly in recent years with a remarkable increase in antibiotic resistance. ESBL and carbapenemases production related to plasmid dissemination are particularly noteworthy.IMPORTANCESerratia spp. is the third most frequent pathogen involved in outbreaks at neonatal facilities and is primarily associated with bacteremia episodes. In this study, we characterized all causing bloodstream infection (BSI) in patients admitted to our hospital during a 16-year period (2005–2020). Despite having no neonatal intensive care unit in our hospital, this study revealed that Serratia spp. is a relevant pathogen causing BSI in elderly patients with high comorbidity rates. A significant increase of antimicrobial resistance was detected over time, particularly in 2020 and coinciding with the coronavirus disease (COVID-19) pandemic and nosocomial spread of multidrug-resistant Serratia spp. isolates. extended-spectrum β-lactases and carbapenemases genes associated with plasmid dissemination, typically detected in other Enterobacterales species, were also identified, reinforcing the role of Serratia spp. in the antimicrobial resistance landscape. Additionally, this work highlights the need to reclassify the species of Serratia, since discrepancies were observed in the identification when using different tools.
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- 2024
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37. Small-sided game-related physical performance is not influenced by the sprint and power performance of youth male soccer players
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Daniel Castillo, Diego Marqués-Jiménez, Silvia Sánchez-Díaz, and Javier Raya-González
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demands ,football ,strength ,velocity ,youth ,Medicine (General) ,R5-920 - Abstract
The aim of this study was to analyse the effects of sprint and power performance on physical fitness and small-sided game-related physical performance in youth male soccer players, using a median split analysis to separate faster and slower players, and powerful and weaker ones. Thirty youth male soccer players (age = 16.9 ± 1.4 years; height = 174.1 ± 7.1 cm; body mass = 63.1 ± 7.9 kg; % body fat = 15.5 ± 3.2) completed the following physical tests: 40 m linear sprint test, repeated sprint ability (RSA) test, countermovement jump (CMJ), horizontal jump (HJ) and a half-squat (HS) power test. In addition, players completed a 4 vs. 4 with goalkeepers small-sided game while external loads were recorded. According to their sprint and HS power performance, players were divided into fast and slow, and powerful and weak. Faster players performed better in 5 m sprint (p = 0.004, Effect Size (ES) = −1.158), 10 m sprint (p < 0.001, ES = −1.722), 40 m sprint (p < 0.001, ES = −3.268), RSAbest (p < 0.001, ES = −2.415), RSAtotal (p < 0.001, ES = −2.785), CMJ height (p = 0.032, ES = 0.823) and HJ distance (p < 0.001, ES = 1.589), but no significant differences (p > 0.05) were found in external loads during small-side games (SSG). In addition, no significant differences (p > 0.05) were observed between powerful and weaker players in the fitness tests and SSG-related physical performance. These results highlight the importance of grouping youth soccer players by their sprinting capacity to design specific and individualized training strategies and suggest that SSG-related physical performance is not influenced by their sprint or power performance.
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- 2023
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38. Alactic base excess predicts the use of renal replacement therapy in patients with septic shock
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Jesús S. Sánchez Díaz, Karla Gabriela Peniche Moguel, Fabiola Buelna Gaxiola, José M. Reyes Ruiz, Orlando R. Pérez Nieto, and María V. Calyeca Sánchez
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Alactic base excess ,Renal replacement therapy ,Septic shock ,Acute kidney injury ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Abstract Background Alactic base excess (ABE) is a novel biomarker that estimates the renal capability of handling acid–base alterations during the sepsis. Hence, the aim of this study was to evaluate the use of ABE to predict the renal replacement therapy (RRT) in patients with septic shock. Methods A total of 164 patients admitted to the intensive care units with a diagnosis of septic shock according to the third international consensus on sepsis and septic shock (Sepsis-3) were included. This study was retrospective, single center, and conducted between January 1, 2016, and December 31, 2020. The individuals were stratified in patients who did [n = 68] or did not [n = 96] receive the RRT. The diagnostic performed of the variables for the classification into patients who required RRT was evaluated by receiver operating characteristic (ROC) analysis and area under curve (AUC) was calculated. Univariate and multivariate logistic regression models were used to identify risk factors for RRT. Results The median age of the patients was 59 years and female sex (51.8%) predominated. ABE (odds ratio [OR] 1.2270, [95% confidence interval [CI] 1.0453–1.4403], p = 0.0124) and urea (OR 1.0114, [95% CI 1.0053–1.0176], p = 0.0002) were associated with risk of RRT. HCO3− (OR 0.6967, [95% CI 0.5771–0.8410], p = 0.0002) was a protective factor of RRT. ABE (AUC = 0.649, p 75 mg/dL, respectively. Conclusion Although HCO3− is associated with low risk, ABE and urea are independent risk factors for RRT in the patients with septic shock.
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- 2023
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39. Design methodology and simulation analysis of hybrid fuel cell and battery systems for powering unmanned aircraft systems
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Marqués, Raúl, Montero, Álvaro, Sánchez-Diaz, Carlos, and Quintanilla, Israel
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- 2024
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40. Smart loading zones. A data analytics approach for loading zones network design
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Castrellon, Juan Pablo, Sanchez-Diaz, Ivan, and Gil, Jorge
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- 2024
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41. [Translated article] Requirements for Accessing New Dermatology Drugs in Spain: Results of the EQUIDAD Study
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Sánchez-Díaz, M., Flórez, Á., Ara-Martín, M., Arias-Santiago, S., Botella-Estrada, R., Cañueto, J., Carretero-Hernández, G., Coto-Segura, P., de Eusebio-Murillo, E., García-Latasa de Araníbar, F.J., García-Patos Briones, V., Gardeazabal García, J., Gómez-Fernández, C., Hernández-Ostiz, S., Izu Belloso, R., López-Ávila, A., Manchado López, P., Martín-Santiago, A., Martinez de Espronceda Ezquerro, I., Mateu-Puchades, A., Mercader-García, P., Notario Rosa, J., Palacio Aller, L., Pérez-Hortet, C., Quintana-Castanedo, L., Rivera, R., Rocamora Duran, V., Rodríguez-Nevado, I.M., Ruiz-Villaverde, R., Suárez, J., Trasobares-Marugán, L., Vizán-de Uña, C., Yanguas, I., Zulaica-Garate, A., García-Doval, I., Descalzo, M.Á., Grau-Pérez, M., and Carrascosa-Carrillo, J.M.
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- 2024
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42. [Translated article] Quality of Professional Life Among Dermatologists: Impact of the COVID-19 Pandemic and Suggestions for Improvement
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Soto-Moreno, A., Ureña-Paniego, C., Montero-Vílchez, T., Sánchez-Díaz, M., Díaz-Calvillo, P., Rodríguez-Pozo, J.A., Molina-Leyva, A., Martínez-López, A., Buendía-Eisman, A., and Arias-Santiago, S.
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- 2024
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43. [Artículo traducido] Impacto de la pandemia COVID-19 en el carcinoma de células escamosas cutáneo: un estudio unicéntrico de los factores epidemiológicos, clínicos e histopatológicos
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Díaz-Calvillo, P., Sánchez-Díaz, M., Rodríguez-Pozo, J.Á., Martínez-Ruiz, V., Martínez-López, A., and Arias-Santiago, S.
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- 2024
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44. Condicionantes de acceso a nuevos medicamentos dermatológicos en España: resultados del proyecto EQUIDAD
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Sánchez-Díaz, M., Flórez, Á., Ara-Martín, M., Arias-Santiago, S., Botella-Estrada, R., Cañueto, J., Carretero-Hernández, G., Coto-Segura, P., de Eusebio-Murillo, E., García-Latasa de Araníbar, F.J., García-Patos Briones, V., Gardeazabal García, J., Gómez-Fernández, C., Hernández-Ostiz, S., Izu Belloso, R., López-Ávila, A., Manchado López, P., Martín-Santiago, A., Martinez de Espronceda Ezquerro, I., Mateu-Puchades, A., Mercader-García, P., Notario Rosa, J., Palacio Aller, L., Pérez-Hortet, C., Quintana-Castanedo, L., Rivera, R., Rocamora Duran, V., Rodríguez-Nevado, I.M., Ruiz-Villaverde, R., Suárez, J., Trasobares-Marugán, L., Vizán-de Uña, C., Yanguas, I., Zulaica-Garate, A., García-Doval, I., Descalzo, M.Á., Grau-Pérez, M., and Carrascosa-Carrillo, J.M.
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- 2024
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45. Calidad de vida profesional en dermatología: impacto de la pandemia y propuestas de mejora
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Soto-Moreno, A., Ureña-Paniego, C., Montero-Vílchez, T., Sánchez-Díaz, M., Díaz-Calvillo, P., Rodríguez-Pozo, J.A., Molina-Leyva, A., Martínez-López, A., Buendía-Eisman, A., and Arias-Santiago, S.
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- 2024
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46. Impact of COVID-19 Pandemic on Cutaneous Squamous Cell Carcinoma: A Single-Centre Study of Epidemiologic, Clinic and Histopathological Factors
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Díaz-Calvillo, P., Sánchez-Díaz, M., Rodríguez-Pozo, J.Á., Martínez-Ruiz, V., Martínez-López, A., and Arias-Santiago, S.
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- 2024
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47. Fanpy: A Python Library for Prototyping Multideterminant Methods in Ab Initio Quantum Chemistry
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Kim, Taewon David, Richer, Michael, Sánchez-Díaz, Gabriela, Heidar-Zadeh, Farnaz, Verstraelen, Toon, Miranda-Quintana, Ramón Alain, and Ayers, Paul W.
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Physics - Chemical Physics ,Condensed Matter - Strongly Correlated Electrons - Abstract
Fanpy is a free and open-source Python library for developing and testing multideterminant wavefunctions and related ab initio methods in electronic structure theory. The main use of Fanpy is to quickly prototype new methods by making it easier to transfer the mathematical conception of a new wavefunction ans\"{a}tze to a working implementation. Fanpy uses the framework of our recently introduced Flexible Ansatz for N-electron Configuration Interaction (FANCI), where multideterminant wavefunctions are represented by their overlaps with Slater determinants of orthonormal spin-orbitals. In the simplest case, a new wavefunction ansatz can be implemented by simply writing a function for evaluating its overlap with an arbitrary Slater determinant. Fanpy is modular in both implementation and theory: the wavefunction model, the system's Hamiltonian, and the choice of objective function are all independent modules. This modular structure makes it easy for users to mix and match different methods and for developers to quickly try new ideas. Fanpy is written purely in Python with standard dependencies, making it accessible for most operating systems; it adheres to principles of modern software development, including comprehensive documentation, extensive testing, and continuous integration and delivery protocols. This article is considered to be the official release notes for the Fanpy library.
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- 2021
48. Loss Allocation in Submarine Armored Three-core HVAC Power Cables.
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Juan Carlos Del-Pino-López, Pedro Cruz-Romero, and Luis Carlos Sánchez-Díaz
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- 2024
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49. Waveguide Amplifiers and Lasers Based on FASnI3 Perovskite Thin Films.
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Isaac Suárez, Hamid Pashai Adl, Vladimir S. Chirvony, Jesús Sánchez-Díaz, Rafael S. Sánchez, Iván Mora-Seró, and Juan P. Martínez-Pastor
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- 2023
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50. Comparing Metaheuristic Optimization Algorithms for Ambulance Allocation: An Experimental Simulation Study.
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Magnus Eide Schjølberg, Nicklas Paus Bekkevold, Xavier F. C. Sánchez-Díaz, and Ole Jakob Mengshoel
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- 2023
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