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The shape of a liquid-air interface advancing on a heterogeneous surface was studied experimentally, together with the force induced by the pinning of the contact line to surface defects. Different surfaces were considered with circular defects introduced as arrays of cocoa butter patches or small circular holes. These heterogeneous surfaces were submerged into aqueous ethanol solutions, while measuring the additional force arising from the deformation of the advancing contact line and characterising the interface shape and its pinning on the defects. Initially, the submersion force is linear with submerged depth, suggesting a constant defect-induced stiffness. This regime ends when the contact line de pins from the defects. A simple scaling is proposed to describe the depinning force and the depinning energy. We find that, as the defect separation increases, the interface stiffness increases too, with a weak dependency on the defect radius. This interaction between defects cannot be captured by the simple scaling, but can be well predicted by a theory considering the interface deformation in presence of periodic arrays of holes. Creating a 4-phase contact line, by including solid defects (cocoa butter) reduced pinning forces. The radius of the defect had a nonlinear effect on the depinning depth. The 4-phase contact line resulted in depinning before the defects are fully submerged. These experimental results and the associated theory help understanding quantitatively the extent to which surface heterogeneities can slow down wetting. This in turn paves the way to tailor the design of heterogeneous surfaces, towards desired wetting performances.

The development of novel texture adaptations for the management of swallowing disorders could be accelerated if reliable in vitro tests were made available. This study addresses some of the limitations of swallowing in vitro models, by introducing a soft robotic actuator inspired by the tongue. The wettability of the soft-robotic actuator was engineered to achieve physiologically relevant contact angles to allow comparing dry and lubricated conditions. The actuator design and the control algorithm are designed to offer flexibility in the swallowing patterns to consider different scenarios, including poor lingual coordination. In vitro swallowing tests with shear thinning liquids were performed as a proof of concept and showed physiologically relevant oral transit time, bolus velocity and palatal pressure. Both the bolus rheology and the coordination of the peristaltic contractions influenced the temporal evolution of the bolus velocity and the bolus transit time. This novel soft robotic tongue, its integration in an in vitro oral cavity and its flexible control can therefore contribute to developing better solutions to manage swallowing disorders.

Swallowing disorders deteriorate significantly the quality of life and can be lifethreatening. Texture modification using shear thinning food thickeners have proven effective in the management of dysphagia. Some studies have recently considered the positive role of cohesiveness, but there is still an insufficient understanding of the effect of the rheological properties of the liquid bolus on the dynamics of bolus transport, particularly when elasticity and extensional properties are combined with a shear thinning behaviour. This study combines steady shear, SAOS and capillary breakage extensional rheometry with an in vitro method to characterize the oral transport of elastic liquids. Bolus velocity and bolus length were measured from in vitro experiments using image analysis and related to the shear and extensional properties. A theory describing the bolus dynamics shows that the elastic and extensional properties do not influence significantly the oral transit dynamics. Conversely, in vitro results suggest that the extensional properties can affect the transition from the oral to the pharyngeal phase of swallowing, where thin, viscoelastic liquids lead to a fast transit, lower oral post-swallow residues and more compact bolus with a smoother surface, which may suggest a lower risk of fragmentation. This mechanistic explanation suggests that the benefit of the extensional properties of thin viscoelastic liquids in the management of dysphagia should be further evaluated in clinical trials.

Mixing grains with different properties is a remarkably challenging process, relevant to many industrial applications. Rotating drums have been used extensively as model systems to study granular media flow and mixing and segregation. Numerous studies considered the mixing of grains with different sizes, but only few studies considered shape and elongation, which have been already identified as important characteristics affecting packing and inducing segregation. In this contribution, the mixing of binary mixtures of grains having the same volume, but different elongations was studied experimentally. The mixing dynamics of a layered granular medium was characterized in a rotating drum, highlighting the impact of the grain shape, of the drum angular speed and of the drum filling ratio. A mixed or segregated state is reached very rapidly, but experiments are continued to verify that the state reached is a steady state. The experiments demonstrated that below a critical difference of elongation, the grains can be mixed effectively. Conversely, when grain elongations are very different, a central core is formed, rich in the more elongated grains. In this case only limited mixing can be achieved. These results can guide the formulation of mixtures of grains with different elongations.

Interest for in silico modelling of the absorption of xenobiotics into the skin has been growing in the last years, owing to their lower cost compared to experimental alternatives, and the desire to avoid animal experimentation. This review presents an overview of Physiologically-Based Pharmacokinetic (PBPK) models and focuses on recent, modelling approaches, such as Finite Element and Lattice Boltzmann. These methods allow for a detailed geometric representation of the skin microstructure, in contrast to classic QSPR and compartmental models. Morphological features of the skin such as the bricks and mortar description of the stratum corneum, hair follicles, and the pilosebaceous unit can therefore be represented more accurately, allowing a better description of the interaction of cosmetics with the skin. This review also highlights several perspectives to further develop these models in directions relevant to industry.

Flexible dosing and ease of swallowing are key factors when designing oral drug delivery systems for paediatric and geriatric populations. Multi-particulate oral dosage forms can offer significant benefits over conventional capsules and tablets. This study proposes the use of an in vitro model to quantitatively investigate the swallowing dynamics in presence of multi-particulates. In vitro results were compared against sensory tests that considered the attributes of ease of swallowing and post-swallow residues. Water and hydrocolloids were considered as suspending vehicles, while the suspended phase consisted of cellulose pellets of two different average sizes. Both in vivo and in vitro tests reported easier swallow for smaller multi-particulates. Besides, water thin liquids appeared not optimal for complete oral clearance of the solids. The sensory study did not highlight significant differences between the levels of thickness of the hydrocolloids. Conversely, more discriminant results were obtained from in vitro tests, suggesting that a minimum critical viscosity is necessary to enable a smooth swallow, but increasing too much the carrier concentration affects swallowing negatively. These results highlight the important interplay of particle size and suspending vehicle rheology and the meaningful contribution that in vitro methods can provide to pre-screening multi-particulate oral drug delivery systems before sensory evaluation.