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2,493 results on '"A. RUSSELL JONES"'

2. Effects of atmospheric pressure change during flight on insulin pump delivery and glycaemic control of pilots with insulin-treated diabetes: an in vitro simulation and a retrospective observational real-world study

Author

Garden, Gillian L., Fan, Ka Siu, Paterson, Megan, Shojaee-Moradie, Fariba, Borg Inguanez, Monique, Manoli, Antonios, Edwards, Victoria, Lee, Vivienne, Frier, Brian M., Hutchison, Ewan J., Maher, Declan, Mathieu, Chantal, Mitchell, Stuart J., Heller, Simon R., Roberts, Graham A., Shaw, Kenneth M., Koehler, Gerd, Mader, Julia K., King, Bruce R., and Russell-Jones, David L.

Published
2025
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3. Metastatic breast cancer cells are metabolically reprogrammed to maintain redox homeostasis during metastasis

Author

Marco Biondini, Camille Lehuédé, Sébastien Tabariès, Matthew G. Annis, Alain Pacis, Eric H. Ma, Christine Tam, Brian E. Hsu, Yannick Audet-Delage, Afnan Abu-Thuraia, Charlotte Girondel, Valerie Sabourin, Stephanie P. Totten, Mariana de Sá Tavares Russo, Gaëlle Bridon, Daina Avizonis, Marie-Christine Guiot, Julie St-Pierre, Josie Ursini-Siegel, Russell Jones, and Peter M. Siegel

Subjects
Glutathione, Breast cancer, Liver metastasis, Oxidative stress, Metabolism, Glycolysis, Medicine (General), R5-920, Biology (General), QH301-705.5
Abstract

Metabolic rewiring is essential for tumor growth and progression to metastatic disease, yet little is known regarding how cancer cells modify their acquired metabolic programs in response to different metastatic microenvironments. We have previously shown that liver-metastatic breast cancer cells adopt an intrinsic metabolic program characterized by increased HIF-1α activity and dependence on glycolysis. Here, we confirm by in vivo stable isotope tracing analysis (SITA) that liver-metastatic breast cancer cells retain a glycolytic profile when grown as mammary tumors or liver metastases. However, hepatic metastases exhibit unique metabolic adaptations including elevated expression of genes involved in glutathione (GSH) biosynthesis and reactive oxygen species (ROS) detoxification when compared to mammary tumors. Accordingly, breast-cancer-liver-metastases exhibited enhanced de novo GSH synthesis. Confirming their increased capacity to mitigate ROS-mediated damage, liver metastases display reduced levels of 8-Oxo-2′-deoxyguanosine. Depletion of the catalytic subunit of the rate-limiting enzyme in glutathione biosynthesis, glutamate-cysteine ligase (GCLC), strongly reduced the capacity of breast cancer cells to form liver metastases, supporting the importance of these distinct metabolic adaptations.Loss of GCLC also affected the early steps of the metastatic cascade, leading to decreased numbers of circulating tumor cells (CTCs) and impaired metastasis to the liver and the lungs. Altogether, our results indicate that GSH metabolism could be targeted to prevent the dissemination of breast cancer cells.

Published
2024
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7. Intrapulmonary shunting is a key contributor to hypoxia in COVID-19: An update on the pathophysiology.

Author

Nikhil Mayor, Harry Knights, Aleksandra Kotwica, Andrew Solomon Joseph Coppola, Harriet Hunter, Nathan Jeffreys, Alexander Morgan, Shivani Gupta, James Prentice, Rebecca Macfarlane, Emma Russell-Jones, Theodore Dassios, and David Russell-Jones

Subjects
Medicine, Science
Abstract

BackgroundThe pathophysiology of COVID-19 remains poorly understood. We aimed to estimate the contribution of intrapulmonary shunting and ventilation-to-perfusion (VA/Q) mismatch using a mathematical model to construct oxygen-haemoglobin dissociation curves (ODCs).MethodsODCs were constructed using transcutaneous pulse oximetry at two different fractions of inspired oxygen (FiO2). 199 patients were included from two large district general hospitals in the South East of England from 1st to 14th January 2021. The study was supported by the National Institute of Health Research (NIHR) Clinical Research Network.ResultsOverall mortality was 29%. Mean age was 68.2 years (SEM 1·2) with 46% female. Median shunt on admission was 17% (IQR 8-24.5); VA/Q was 0.61 (IQR 0.52-0.73). Shunt was 37.5% higher in deaths (median 22%, IQR 9-29) compared to survivors (16%, 8-21; p = 0.0088) and was a predictor of mortality (OR 1.04; 95% CI 1.01-1.07). Admission oxygen saturations were more strongly predictive of mortality (OR 0.91, 95% CI 0.87-0.96). There was no difference in VA/Q mismatch between deaths (0.60; IQR 0.50-0.73) and survivors (0.61; IQR 0.52-0.73; p = 0.63) and it was not predictive of mortality (OR 0.68; 95% CI 0.18-2.52; p = 0.55). Shunt negatively correlated with admission oxygen saturation (R -0.533; pInterpretationShunt, not VA/Q mismatch, was associated with worsening hypoxia, though calculating shunt was not of prognostic value. This study adds to our understanding of the pathophysiology of hypoxaemia in COVID-19. Our inexpensive and reliable technique may provide further insights into the pathophysiology of hypoxia in other respiratory diseases.

Published
2022
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9. Leveraging advances in diabetes technologies in primary care: a narrative review

Author

Bruce Bode, Aaron King, David Russell-Jones, and Liana K. Billings

Subjects
Continuous glucose monitoring, diabetes technologies, insulin delivery systems, self-measured blood glucose, time in range, Medicine
Abstract

AbstractPrimary care providers (PCPs) play an important role in providing medical care for patients with type 2 diabetes. Advancements in diabetes technologies can assist PCPs in providing personalised care that addresses each patient’s individual needs. Diabetes technologies fall into two major categories: devices for glycaemic self-monitoring and insulin delivery systems. Monitoring technologies encompass self-measured blood glucose (SMBG), where blood glucose is intermittently measured by a finger prick blood sample, and continuous glucose monitoring (CGM) devices, which use an interstitial sensor and are capable of giving real-time information. Studies show people using real-time CGM have better glucose control compared to SMBG. CGM allows for new parameters including time in range (the time spent within the desired target glucose range), which is an increasingly relevant real-time metric of glycaemic control. Insulin pens have increased the ease of administration of insulin and connected pens that can calculate and capture data on dosing are becoming available. There are a number of websites, software programs, and applications that can help PCPs and patients to integrate diabetes technology into their diabetes management schedules. In this article, we summarise these technologies and provide practical information to inform PCPs about utility in their clinical practice. The guiding principle is that use of technology should be individualised based on a patient’s needs, desires, and availability of devices. Diabetes technology can help patients improve their clinical outcomes and achieve the quality of life they desire by decreasing disease burden.KEY MESSAGESIt is important to understand the role that diabetes technologies can play in primary care to help deliver high-quality care, taking into account patient and community resources. Diabetes technologies fall into two major categories: devices for glycaemic self-monitoring and insulin delivery systems. Modern self-measured blood glucose devices are simple to use and can help guide decision making for self-management plans to improve clinical outcomes, but cannot provide “live” data and may under- or overestimate blood glucose; patients’ monitoring technique and compliance should be reviewed regularly. Importantly, before a patient is provided with monitoring technology, they must receive suitably structured education in its use and interpretation.Continuous glucose monitoring (CGM) is now standard of care for people with type 1 diabetes and people with type 2 diabetes on meal-time (prandial) insulin. Real-time CGM can tell both the patient and the healthcare provider when glucose is in the normal range, and when they are experiencing hyper- or hypoglycaemia. Using CGM data, changes in lifestyle, eating habits, and medications, including insulin, can help the patient to stay in a normal glycaemic range (70–180 mg/dL). Real-time CGM allows for creation of an ambulatory glucose profile and monitoring of time in range (the time spent within target blood glucose of 70–180 mg/dL), which ideally should be at least 70%; avoiding time above range (>180 mg/dL) is associated with reduced diabetes complications and avoiding time below range (

Published
2021
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10. The voice of the outcast : Josephine Butler's Biblical interpretation and public theology

Author

Russell-Jones, Amanda Barbara

Subjects
900, BS The Bible, BX Christian Denominations, DA Great Britain
Abstract

This thesis argues that Josephine Butler cannot be understood as a campaigner and biblical interpreter apart from her core self-understanding as 'the voice of the outcast'. Part One, 'The Making of a Prophet', demonstrates that Butler’s chosen term 'outcast' has a biblical background and explores the key influence of anti-slavery on her interpretation of Scripture. Her husband George’s biblical interpretation is shown to be an important but previously overlooked parallel to her own. The close relationship and theological affinity she had with the women of the Salvation Army is seen to result in important developments in their mutual thought and praxis. Part Two, 'The Voice of a Prophet', analyses her innovative gendered exegesis and its application to the critical issue of the day — the sexual double standard. Parallels between the interpretative techniques she employed and those of later women bible interpreters like Phyllis Trible are explored. Parallels with Womanist and Mujerista readings on behalf of the oppressed are delineated. Butler is seen to be a radical prophetic voice in the public sphere who deliberately and subversively interpreted Scripture into the culture of her day to demand inclusion of the outcast and challenge the standards of church and state.

Published
2015

12. Open data from the first and second observing runs of Advanced LIGO and Advanced Virgo

Author

Rich Abbott, Thomas D. Abbott, Sheelu Abraham, Fausto Acernese, Kendall Ackley, Carl Adams, Rana X. Adhikari, Vaishali B. Adya, Christoph Affeldt, Michalis Agathos, Kazuhiro Agatsuma, Nancy Aggarwal, Odylio D. Aguiar, Amit Aich, Lorenzo Aiello, Anirban Ain, Ajith Parameswaran, Gabrielle Allen, Annalisa Allocca, Paul A. Altin, Alex Amato, Shreya Anand, Alena Ananyeva, Stuart B. Anderson, Warren G. Anderson, Svetoslava V. Angelova, Stefano Ansoldi, Sarah Antier, Stephen Appert, Koji Arai, Melody C. Araya, Joseph S. Areeda, Marc Arène, Nicolas Arnaud, Scott M. Aronson, Kg G. Arun, Stefano Ascenzi, Gregory Ashton, Stuart M. Aston, Pia Astone, Florian Aubin, Peter Aufmuth, Kellie AultONeal, Corey Austin, Valerie Avendano, Stanislav Babak, Philippe Bacon, Francesca Badaracco, Maria K.M. Bader, Sangwook Bae, Anne M. Baer, Jonathon Baird, Francesca Baldaccini, Giulio Ballardin, Stefan W. Ballmer, Anna-marie Bals, Alexander Balsamo, Gregory Baltus, Sharan Banagiri, Deepak Bankar, Rameshwar S. Bankar, Juan C. Barayoga, Claudio Barbieri, Barry C. Barish, David Barker, Kevin Barkett, Pablo Barneo, Fabrizio Barone, Bryan Barr, Lisa Barsotti, Matteo Barsuglia, Daniel Barta, Jeffrey Bartlett, Imre Bartos, Riccardo Bassiri, Andrea Basti, Mateusz Bawaj, Joseph C. Bayley, Marco Bazzan, Bence Bécsy, Michal Bejger, Imene Belahcene, Angus S. Bell, Deeksha Beniwal, Michael G. Benjamin, Joe D. Bentley, Fabio Bergamin, Beverly K. Berger, Gerald Bergmann, Sebastiano Bernuzzi, Christopher P.L. Berry, Diego Bersanetti, Alessandro Bertolini, Joseph Betzwieser, Rohan Bhandare, Ankit V. Bhandari, Jeffrey Bidler, Edward Biggs, Igor A. Bilenko, Garilynn Billingsley, Ross Birney, Ofek Birnholtz, Sebastien Biscans, Matteo Bischi, Sylvia Biscoveanu, Aparna Bisht, Guldauren Bissenbayeva, Massimiliano Bitossi, Marieanne A. Bizouard, Kent K. Blackburn, Jonathan Blackman, Carl D. Blair, David G. Blair, Ryan M. Blair, Fabrizio Bobba, Nina Bode, Michel Boer, Yannick Boetzel, Gilles Bogaert, Francois Bondu, Edgard Bonilla, Romain Bonnand, Phillip Booker, Boris A. Boom, Rolf Bork, Valerio Boschi, Sukanta Bose, Vladimir Bossilkov, Joel Bosveld, Yann Bouffanais, Antonella Bozzi, Carlo Bradaschia, Patrick R. Brady, Alyssa Bramley, Marica Branchesi, Jim E. Brau, Matteo Breschi, Tristan Briant, Joseph H. Briggs, Francesco Brighenti, Alain Brillet, Marc Brinkmann, Patrick Brockill, Aidan F. Brooks, Jonathan Brooks, Daniel D. Brown, Sharon Brunett, Giacomo Bruno, Robert Bruntz, Aaron Buikema, Tomasz Bulik, Henk J. Bulten, Alessandra Buonanno, Damir Buskulic, Robert L. Byer, Miriam Cabero, Laura Cadonati, Giampietro Cagnoli, Craig Cahillane, Juan Calderón Bustillo, Jack D. Callaghan, Thomas A. Callister, Enrico Calloni, Jordan B. Camp, Maurizio Canepa, Kipp C. Cannon, Huy-tuong Cao, Junwei Cao, Giovanni Carapella, Franco Carbognani, Santiago Caride, Matthew F. Carney, Gregorio Carullo, Julia Casanueva Diaz, Claudio Casentini, Javier Castañeda, Sarah Caudill, Marco Cavaglià, Fabien Cavalier, Roberto Cavalieri, Giancarlo Cella, Pablo Cerdá-Durán, Elisabetta Cesarini, Oualid Chaibi, Kabir Chakravarti, Chiwai Chan, Manleong Chan, Shiuh Chao, Philip Charlton, Eve A. Chase, Eric Chassande-Mottin, Deep Chatterjee, Mayank Chaturvedi, Hsin-yu Y. Chen, Xu Chen, Yanbei Chen, Hai-ping Cheng, Chi-kit K. Cheong, Hanyu Y. Chia, Francesco Chiadini, Roberto Chierici, Andrea Chincarini, Antonino Chiummo, Gihyuk Cho, Heesuk S. Cho, Min-a Cho, Nelson Christensen, Qi Chu, Sheon Chua, Ka-wai W. Chung, Shinkee Chung, Giacomo Ciani, Pawel Ciecielag, Marek Cieślar, Alexei A. Ciobanu, Riccardo Ciolfi, Francesco Cipriano, Alessio Cirone, Filiberto Clara, James A. Clark, Patrick Clearwater, Sebastien Clesse, Frederic Cleva, Eugenio Coccia, Pierre-francois Cohadon, David Cohen, Marta Colleoni, Christophe G. Collette, Christopher Collins, Monica Colpi, Marcio Constancio Jr., Livia Conti, Sam J. Cooper, Paul Corban, Thomas R. Corbitt, Isabel Cordero-Carrión, Silvia Corezzi, Kenneth R. Corley, Neil Cornish, David Corre, Alessandra Corsi, Stefano Cortese, Cesar A. Costa, Roberto Cotesta, Michael W. Coughlin, Scott B. Coughlin, Jeanpierre Coulon, Stefan T. Countryman, Peter Couvares, Pep B. Covas, David M. Coward, Matthew J. Cowart, Dennis C. Coyne, Robert Coyne, Jolien D. E. Creighton, Teviet D. Creighton, Jonathan Cripe, Michael Croquette, Sgwynne G. Crowder, Jean-rene Cudell, Torrey J. Cullen, Alan Cumming, Rebecca Cummings, Liam Cunningham, Elena Cuoco, Malgorzata Curylo, Tito Dal Canton, Gergely Dálya, Aykutlu Dana, Lara M. Daneshgaran-Bajastani, Beatrice D’Angelo, Stefan L. Danilishin, Sabrina D’Antonio, Karsten Danzmann, Christian Darsow-Fromm, Arnab Dasgupta, Laurence E. H. Datrier, Vincenzo Dattilo, Ishant Dave, Michel Davier, Gareth S. Davies, Derek Davis, Edward J. Daw, Dan DeBra, Malathi Deenadayalan, Jerome Degallaix, Martina De Laurentis, Samuel Deléglise, Matthew Delfavero, Nicola De Lillo, Walter Del Pozzo, Lindsay M. DeMarchi, Virginia D’Emilio, Nicholas Demos, Thomas Dent, Roberto De Pietri, Rosario De Rosa, Camilla De Rossi, Riccardo DeSalvo, Omar de Varona, Sanjeev Dhurandhar, Mario C. Díaz, Mauricio Diaz-Ortiz Jr., Tim Dietrich, Luciano Di Fiore, Chiara Di Fronzo, Cinzia Di Giorgio, Fabrizio Di Giovanni, Matteo Di Giovanni, Tristano Di Girolamo, Alberto Di Lieto, Binlei Ding, Sibilla Di Pace, Irene Di Palma, Francesco Di Renzo, Atul K. Divakarla, Artemiy Dmitriev, Zoheyr Doctor, Fred Donovan, Katherine L. Dooley, Suresh Doravari, Iain Dorrington, Thomas P. Downes, Marco Drago, Jenne C. Driggers, Zhihui Du, Jean-gregoire Ducoin, Peter Dupej, Ofelia Durante, Domenico D’Urso, Sheila E. Dwyer, Paul J. Easter, Graeme Eddolls, Bruce Edelman, Tega B. Edo, Oliver Edy, Anamaria Effler, Phil Ehrens, Johannes Eichholz, Stephen S. Eikenberry, Marc Eisenmann, Robert A. Eisenstein, Aldo Ejlli, Lucianolucianikerrico Errico, Reed C. Essick, Hector Estelles, Dimitri Estevez, Zachariah B. Etienne, Todd Etzel, Matthew Evans, Tom M. Evans, Rebecca E. Ewing, Viviana Fafone, Stephen Fairhurst, Xilong Fan, Stefania Farinon, Benjamin Farr, Will M. Farr, Edward J. Fauchon-Jones, Marc Favata, Maxime Fays, Mariana Fazio, Jon Feicht, Martin M. Fejer, Fangchen Feng, Edit Fenyvesi, Deborah L. Ferguson, Alvaro Fernandez-Galiana, Isidoro Ferrante, Elvis C. Ferreira, Tabata A. Ferreira, Francesco Fidecaro, Irene Fiori, Donatella Fiorucci, Maya Fishbach, Ryan P. Fisher, Rosalba Fittipaldi, Margot Fitz-Axen, Vincenzo Fiumara, Raffaele Flaminio, Erik Floden, Eric Flynn, Heather Fong, Antonio A. Font, Perry Forsyth, Jean-daniel Fournier, Sergio Frasca, Franco Frasconi, Zsolt Frei, Andreas Freise, Raymond Frey, Valentin Frey, Peter Fritschel, Valery V. Frolov, Gabriele Fronzè, Paul Fulda, Michael Fyffe, Hunter A. Gabbard, Bhooshan U. Gadre, Sebastian M. Gaebel, Jonathan R. Gair, Shanika Galaudage, Dhruva Ganapathy, Sharad G. Gaonkar, Cecilio García-Quirós, Fabio Garufi, Bubba Gateley, Sergio Gaudio, Gayathri Gayathri, Gianluca Gemme, Eric Genin, Alberto Gennai, Daniel George, Jogy George, Laszlo Gergely, Sudarshan Ghonge, Abhirup Ghosh, Archisman Ghosh, Shaon Ghosh, Bruno Giacomazzo, Joe A. Giaime, Dwayne D. Giardina, Des R. Gibson, Chalisa Gier, Kiranjyot Gill, Jane Glanzer, Jan Gniesmer, Patrick Godwin, Evan Goetz, Ryan Goetz, Niklas Gohlke, Boris Goncharov, Gabriela González, Gopakumar Gopakumar, Sarah E. Gossan, Matthieu Gosselin, Romain Gouaty, Benjamin Grace, Aniello Grado, Massimo Granata, Alastair Grant, Slawomir Gras, Philippe Grassia, Corey Gray, Rachel Gray, Giuseppe Greco, Anna C. Green, Rhys Green, Elizabeth M. Gretarsson, Hannah L. Griggs, G. Grignani, Andrea Grimaldi, Stefan J. Grimm, Hartmut Grote, Steffen Grunewald, Pierre Gruning, Gianluca M. Guidi, Andre R. Guimaraes, Gerard Guixé, Hitesh K. Gulati, Yuefan Guo, Anuradha Gupta, Anchal Gupta, Pawan Gupta, Eric K. Gustafson, Dick Gustafson, Leila Haegel, Odysse Halim, Evan D. Hall, Eleanor Z. Hamilton, Giles Hammond, Maria Haney, Manuela M. Hanke, Jonathan Hanks, Chad Hanna, Mark D. Hannam, Otto A. Hannuksela, Travis J. Hansen, Joe Hanson, Thomas Harder, Terra Hardwick, Haris Haris, Jan Harms, Gregg M. Harry, Ian W. Harry, Raine K. Hasskew, Carl-johan Haster, Karen Haughian, Fergus J. Hayes, James Healy, Antoine Heidmann, Matthew C. Heintze, Joscha Heinze, Henrich Heitmann, Frances Hellman, Patrice Hello, Gary Hemming, Martin Hendry, Siong S. Heng, Eric Hennes, Jan-simon Hennig, Michele Heurs, Stefan Hild, Tanja Hinderer, Sarah Y. Hoback, Sven Hochheim, Elyssa Hofgard, David Hofman, Aaron M. Holgado, Nathan A. Holland, Kathy Holt, Daniel E. Holz, Paul Hopkins, Christian Horst, James Hough, Eric J. Howell, Charlie G. Hoy, Yiwen Huang, Moritz T. Hübner, Eliu A. Huerta, Dominique Huet, Brennan Hughey, Victor Hui, Sascha Husa, Sabina H. Huttner, Rachael Huxford, Tien Huynh-Dinh, Bartosz Idzkowski, Alberto Iess, Henri Inchauspe, Craig Ingram, Giuseppe Intini, Jean M. Isac, Max Isi, Bala R. Iyer, Thibaut Jacqmin, Sameer J. Jadhav, Shreejit P. Jadhav, Alasdair L. James, Karan Jani, Nagaraj N. Janthalur, Piotr Jaranowski, Deep Jariwala, Rafel Jaume, Alex C. Jenkins, Jun Jiang, Grace R. Johns, Aaron W. Jones, Ian I. Jones, Jeff D. Jones, Philip Jones, Russell Jones, Reinier J. G. Jonker, Ju Ju, Jonas Junker, Chinmay V. Kalaghatgi, Vassiliki Kalogera, Brittany Kamai, Shivaraj Kandhasamy, Gungwon Kang, Jonah B. Kanner, Shasvath J. Kapadia, Sudarshan Karki, Rahul Kashyap, Marie Kasprzack, Wolfgang Kastaun, Stavros Katsanevas, Erik Katsavounidis, William Katzman, Steffen Kaufer, Keita Kawabe, Fabien Kéfélian, David Keitel, Azadeh Keivani, Ross Kennedy, Joey S. Key, Sudiksha Khadka, Farit Y. Khalili, Imran Khan, Sebastian Khan, Zaki A. Khan, Efim A. Khazanov, Nandita Khetan, Mohammad Khursheed, Nutsinee Kijbunchoo, Chunglee Kim, Grace J. Kim, Jeongcho C. Kim, Kyungmin Kim, Won Kim, Whansun S. Kim, Young-min Kim, Charles Kimball, Peter J. King, Maya Kinley-Hanlon, Robin Kirchhoff, Jeffrey S. Kissel, Lisa Kleybolte, Sergei Klimenko, Tyler D. Knowles, Philip Koch, Sina M. Koehlenbeck, Gideon Koekoek, Soumen Koley, Veronica Kondrashov, Antonios Kontos, Nico Koper, Mikhail Korobko, William Z. Korth, Manoj Kovalam, Dan B. Kozak, Volker Kringel, Nv V. Krishnendu, Andrzej Królak, Natalie Krupinski, Gerrit Kuehn, Anil Kumar, Prayush Kumar, Rahul Kumar, Rakesh Kumar, Sumit Kumar, Ling-chi Kuo, Adam Kutynia, Benjamin D. Lackey, Danny Laghi, Emile Lalande, Lam L. Lam, Astrid Lamberts, Michael Landry, Benjamin B. Lane, Ryan N. Lang, Jacob Lange, Brian Lantz, Robert K. Lanza, Iuri La Rosa, Angelique Lartaux-Vollard, Paul D. Lasky, Michael Laxen, Albert Lazzarini, Claudia Lazzaro, Paola Leaci, Sean Leavey, Yannick K. Lecoeuche, Chang-hwan H. Lee, Hyung-mok M. Lee, Hyungwon W. Lee, Joongoo Lee, Kyung-ha Lee, Johannes Lehmann, Nicolas Leroy, Nicolas Letendre, Yuri Levin, Alvin K. Y. Li, Jin Li, Kaye li, Tjonnie G. F. Li, Xiang Li, Frank Linde, Seth D. Linker, Jethro N. Linley, Tyson B. Littenberg, Liu Liu, Xiaoshu Liu, Miquel Llorens-Monteagudo, Ka-lok Lo, Alexandra Lockwood, Lionel T. London, Alessandro Longo, Matteo Lorenzini, Vincent Loriette, Marc Lormand, Giovanni Losurdo, James D. Lough, Carlos O. Lousto, Geoffrey Lovelace, Harald Lück, Diana Lumaca, Andrew P. Lundgren, Ma Yiqiu, Ronaldas Macas, Sean Macfoy, Myron MacInnis, Duncan M. Macleod, Ian O. MacMillan, Adrian Macquet, Ignacio Magaña Hernandez, Fabian Magaña-Sandoval, Ryan M. Magee, Ettore Majorana, Ivan Maksimovic, Asmita Malik, Catherine Man, Vuk Mandic, Valentina Mangano, Georgia L. Mansell, Michael Manske, Maddalena Mantovani, Michela Mapelli, Fabio Marchesoni, Frederique Marion, Szabolcs Márka, Zsuzsanna Márka, Charalampos Markakis, Ashot S. Markosyan, Aaron Markowitz, Ed Maros, Antonio Marquina, Sylvain Marsat, Filippo Martelli, Ian W. Martin, Rodica M. Martin, Valerie Martinez, Denis V. Martynov, Hossein Masalehdan, Ken Mason, Elena Massera, Alain Masserot, Thomas J. Massinger, Mariela Masso-Reid, Simone Mastrogiovanni, Andrew Matas, Fabrice Matichard, Nergis Mavalvala, Emily Maynard, Joshua J. McCann, Richard McCarthy, David E. McClelland, Scott McCormick, Lee McCuller, Stephen C. McGuire, Connor McIsaac, Jessica McIver, David J. McManus, Terry McRae, Sean T. McWilliams, Duncan Meacher, Grant D. Meadors, Moritz Mehmet, Ajit K. Mehta, Elena Mejuto Villa, Andrew Melatos, Gregory Mendell, Adam A. Mercer, Lorenzo Mereni, Kara Merfeld, Edmond L. Merilh, Jonathan D. Merritt, Mourad Merzougui, Syd Meshkov, Chris Messenger, Cody Messick, Remi Metzdorff, Patrick M. Meyers, Fabian Meylahn, Ashish Mhaske, Andrea Miani, Haixing Miao, Ioannis Michaloliakos, Christophe Michel, Hannah Middleton, Leopoldo Milano, Andrewlawrence L. Miller, Meg Millhouse, Joseph C. Mills, Edoardo Milotti, Michael C. Milovich-Goff, Olivier Minazzoli, Yuri Minenkov, Alec Mishkin, Chandra Mishra, Timesh Mistry, Sanjit Mitra, Valery P. Mitrofanov, Guenakh Mitselmakher, Richard Mittleman, Geoffrey Mo, Kentaro Mogushi, Satyanarayan R. P. Mohapatra, Siddharth R. Mohite, Manel Molina-Ruiz, Marina Mondin, Matteo Montani, Christopher J. Moore, Dan Moraru, Filip Morawski, Gerardo Moreno, Soichiro Morisaki, Benoit Mours, Conor M. Mow-Lowry, Simone Mozzon, Federico Muciaccia, Arunava Mukherjee, Debnandini Mukherjee, Soma Mukherjee, Subroto Mukherjee, Nikhil Mukund, Adam Mullavey, Jesper Munch, Erik A. Muñiz, Peter G. Murray, Alessandro Nagar, Ilaria Nardecchia, Luca Naticchioni, Rajesh K. Nayak, Benjamin F. Neil, Joshua Neilson, Gijs Nelemans, Timothy J. N. Nelson, Marina Nery, Ansel Neunzert, Kwan-yeung Y. Ng, Sebastian Ng, Catherine Nguyen, Philippe Nguyen, David Nichols, Shania A. Nichols, Samaya Nissanke, Flavio Nocera, Minkyun Noh, Chris North, Devon Nothard, Laura K. Nuttall, Jason Oberling, Brendan D. O’Brien, Gor Oganesyan, Greg H. Ogin, John J. Oh, Sanghoon H. Oh, Frank Ohme, Hiroaki Ohta, Marcos A. Okada, Miquel Oliver, Christian Olivetto, Patrick Oppermann, Richard Oram, Brian O’Reilly, Rich G. Ormiston, Luis F. Ortega, Richard O’Shaughnessy, Serguei Ossokine, Charles Osthelder, David J. Ottaway, Harry Overmier, Ben J. Owen, Alexander E. Pace, Giulia Pagano, Michael A. Page, Giulia Pagliaroli, Archana Pai, Siddhesh A. Pai, Jordan R. Palamos, Oleg Palashov, Cristiano Palomba, Howard Pan, Pratap K. Panda, Tsun-ho Pang, Chris Pankow, Francesco Pannarale, Brijesh C. Pant, Federico Paoletti, Andrea Paoli, Abhishek Parida, William Parker, Daniela Pascucci, Antonio Pasqualetti, Roberto Passaquieti, Diego Passuello, Barbara Patricelli, Ethan Payne, Brynley L. Pearlstone, Thida C. Pechsiri, Ari J. Pedersen, Mike Pedraza, Arnaud Pele, Steven Penn, Albino Perego, Carlos J. Perez, Perigois Périgois, Antonio Perreca, Stephane Perriès, Jan Petermann, Harald P. Pfeiffer, Margot Phelps, Khun S. Phukon, Ornella J. Piccinni, Mikhael Pichot, Marco Piendibene, Francesco Piergiovanni, Vincenzo Pierro, Gabriel Pillant, Laurent Pinard, Innocenzo M. Pinto, Krzysztof Piotrzkowski, Marc Pirello, Matthew Pitkin, Wolfango Plastino, Rosa Poggiani, Yat-tung T. Pong, Sarah Ponrathnam, Pasquale Popolizio, Ed K. Porter, Jade Powell, Atul K. Prajapati, Kiran Prasai, Raghurama Prasanna, Geraint Pratten, Tanner Prestegard, Maria Principe, Giovanni A. Prodi, Leonid Prokhorov, Michele Punturo, Paola Puppo, Michael Pürrer, Hong Qi, Volker Quetschke, Pedro J. Quinonez, Fred J. Raab, Geert Raaijmakers, Hugh Radkins, Nicholas Radulesco, Peter Raffai, Hanna Rafferty, Sendhil Raja, Rajan Rajan, Binod Rajbhandari, Malik Rakhmanov, Karla E. Ramirez, Antoni Ramos-Buades, Javed Rana, Kaushik Rao, Piero Rapagnani, Vivien Raymond, Massimiliano Razzano, Jocelyn Read, Tania Regimbau, Luca Rei, Stuart Reid, David H. Reitze, Piero Rettegno, Fulvio Ricci, Colter J. Richardson, Jonathan W. Richardson, Paul M. Ricker, Gunnar Riemenschneider, Keith Riles, Monica Rizzo, Norna A. Robertson, Florent Robinet, Alessio Rocchi, Ramon D. Rodriguez-Soto, Loic Rolland, Jameson G. Rollins, Vincent J. Roma, Marco Romanelli, Rocco Romano, Chandra L. Romel, Isobel M. Romero-Shaw, Janeen H. Romie, Caitlin A. Rose, Dakota Rose, Kyle Rose, Dorota Rosińska, Shawn G. Rosofsky, Michael P. Ross, Sheila Rowan, Samuel J. Rowlinson, Palash K. Roy, Santosh Roy, Soumen Roy, Paolo Ruggi, Guntis Rutins, Kyle Ryan, Surabhi Sachdev, Travis Sadecki, Mairi Sakellariadou, Om S. Salafia, Livio Salconi, Muhammed Saleem, Anuradha Samajdar, Eduardo J. Sanchez, Luis E. Sanchez, Nicolas Sanchis-Gual, Jaclyn R. Sanders, Kevin A. Santiago, Edison Santos, Nikhil Sarin, Benoit Sassolas, B S. Sathyaprakash, Orion Sauter, Richard L. Savage, Vaibhav Savant, Disha Sawant, Sihem Sayah, Dean Schaetzl, Paul Schale, Mark Scheel, Jacob Scheuer, Patricia Schmidt, Roman Schnabel, Robert M. S. Schofield, Axel Schönbeck, Emil Schreiber, Bernd W. Schulte, Bernard F. Schutz, Otto Schwarm, Eyal Schwartz, Jamie Scott, Susan M. Scott, Ed Seidel, Danny Sellers, Anand S. Sengupta, Noah Sennett, Daniel Sentenac, Valeria Sequino, Alexander Sergeev, Yoshinta Setyawati, Daniel A. Shaddock, Thomas Shaffer, Selim S. Shahriar, A. Sharma, Priyanka Sharma, Peter Shawhan, Hongyu Shen, Minori Shikauchi, Rosalie Shink, David H. Shoemaker, Deirdre M. Shoemaker, Keerti Shukla, Shyamsundar ShyamSundar, Karelle Siellez, Magdalena Sieniawska, Daniel Sigg, Leo P. Singer, Divya Singh, Neha Singh, Ayatri Singha, Akshat Singhal, Alicia M. Sintes, Valeria Sipala, Vasileios Skliris, Bram J. J. Slagmolen, Teresa J. Slaven-Blair, Jiri Smetana, Joshua R. Smith, Rory J. E. Smith, Surendranadh Somala, Edwin J. Son, Siddharth Soni, Borja Sorazu, Viola Sordini, Fiodor Sorrentino, Tarun Souradeep, Eric Sowell, Andrew P. Spencer, Mario Spera, Amit K. Srivastava, Varun Srivastava, Kai Staats, Cosmin Stachie, Mark Standke, Daniele A. Steer, Michael Steinke, Jessica Steinlechner, Sebastian Steinlechner, Daniel Steinmeyer, Dane Stocks, David J. Stops, Madeline Stover, Ken A. Strain, Giulia Stratta, Amber Strunk, Riccardo Sturani, Amber L. Stuver, Sudhagar Sudhagar, Vivishek Sudhir, Tiffany Z. Summerscales, Ling Sun, Sunil Sunil, Ankan Sur, Jishnu Suresh, Patrick J. Sutton, Bas L. Swinkels, Marek J. Szczepańczyk, Matteo Tacca, Simon C. Tait, Colm Talbot, Andres J. Tanasijczuk, David B. Tanner, Duo Tao, Marton Tápai, Amauri Tapia, Enzo N. Tapia San Martin, Jay D. Tasson, Robert Taylor, Rodrigo Tenorio, Lukas Terkowski, Manasadevi P. Thirugnanasambandam, Michael Thomas, Patrick Thomas, Jonathan E. Thompson, Sivananda R. Thondapu, Keith A. Thorne, Eric Thrane, Calley L. Tinsman, Saravanan R. Saravanan, Shubhanshu Tiwari, Srishti Tiwari, Vaibhav Tiwari, Karl Toland, Mauro Tonelli, Zeno Tornasi, Alejandro Torres-Forné, Calum I. Torrie, Iara Tosta e Melo, Daniel Töyrä, Emily A. Trail, Flavio Travasso, Gary Traylor, Maria C. Tringali, Aashish Tripathee, Agata Trovato, Randy J. Trudeau, Ka-wa W. Tsang, Maggie Tse, Rhondale Tso, Leo Tsukada, Daichi Tsuna, Takuya Tsutsui, Margherita Turconi, Amit S. Ubhi, Koh Ueno, Dennis Ugolini, Cs S. Unnikrishnan, Alexander L. Urban, Samantha A. Usman, Andrei C. Utina, Henning Vahlbruch, Gabriele Vajente, Guillermo Valdes, Michele Valentini, M. Vallisneri, Niels van Bakel, Martin van Beuzekom, Jo F. J. van den Brand, Chris Van Den Broeck, Daniel C. Vander-Hyde, Laura van der Schaaf, Joris V. Van Heijningen, Marielle A. van Veggel, Marco Vardaro, Vijay Varma, Steve Vass, Matyas Vasúth, Alberto Vecchio, Gabriele Vedovato, John Veitch, Peter J. Veitch, Krishna Venkateswara, Gautam Venugopalan, Didier Verkindt, Doga Veske, Flavio Vetrano, Andrea Viceré, Aaron D. Viets, Serena Vinciguerra, David J. Vine, Jeanyves Vinet, Salvatore Vitale, Francisco Hernandez Vivanco, Thomas Vo, Helios Vocca, Cheryl Vorvick, Sergey P. Vyatchanin, Andrew R. Wade, Leslie E. Wade, Madeline Wade, Rob Walet, Marissa Walker, Gavin S. Wallace, Larry Wallace, Sinead Walsh, Jonathan Z. Wang, Sibo Wang, Wenhui H. Wang, Yifan F. Wang, Robert L. Ward, Zane A. Warden, Jim Warner, Michal Was, Jennifer Watchi, Betsy Weaver, Li-wei Wei, Michael Weinert, Alan J. Weinstein, Rainer Weiss, Felix Wellmann, Linqing Wen, Peter Weßels, Jonathan W. Westhouse, Karl Wette, John T. Whelan, Bernard F. Whiting, Chris Whittle, Dennis M. Wilken, Daniel Williams, Roy D. Williams, Andrew R. Williamson, Joshua L. Willis, Benno Willke, Walter Winkler, Christopher C. Wipf, Holger Wittel, Graham Woan, Janis Woehler, Jared K. Wofford, Chun-fung Wong, Jennifer L. Wright, David S. Wu, Daniel M. Wysocki, Liting Xiao, Hiro Yamamoto, Le Yang, Yang Yang, Ziyan Yang, Min-jet J. Yap, Maher Yazback, David W. Yeeles, Hang Yu, Haocun Yu, Shingheirobin Yuen, Adam K. Zadrożny, Adam Zadrożny, Michele Zanolin, Tatiana Zelenova, Jean-pierre Zendri, Michael Zevin, Jue Zhang, Liyuan Zhang, Teng Zhang, Chunnong Zhao, Guoying Zhao, Minchuan Zhou, Zifan Zhou, Xingjiang J. Zhu, Aaron B. Zimmerman, Michael E. Zucker, and John Zweizig

Subjects
GWOSC, Scientific databases, Data representation and management, Gravitational Waves, Computer software, QA76.75-76.765
Abstract

Advanced LIGO and Advanced Virgo are monitoring the sky and collecting gravitational-wave strain data with sufficient sensitivity to detect signals routinely. In this paper we describe the data recorded by these instruments during their first and second observing runs. The main data products are gravitational-wave strain time series sampled at 16384 Hz. The datasets that include this strain measurement can be freely accessed through the Gravitational Wave Open Science Center at http://gw-openscience.org, together with data-quality information essential for the analysis of LIGO and Virgo data, documentation, tutorials, and supporting software.

Published
2021
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14. Attitudes of doctors and nurses toward patient safety within emergency departments of two Saudi Arabian hospitals

Author

Naif Alzahrani, Russell Jones, and Mohamed E. Abdel-Latif

Subjects
Patient safety, Safety attitudes, Patient safety climate, Quality improvement, Team-work, Public aspects of medicine, RA1-1270
Abstract

Abstract Background A hospital culture that promotes and insures patient safety is a critical aspect for the effective delivery of hospital services and patient care. Yet there are significant patient health and safety issues in hospitals worldwide. This study aims to investigate doctors’ and nurses’ attitudes toward patient safety in the emergency departments (ED) of two Saudi hospitals. Method A cross-sectional survey using a validated Safety Attitudes Questionnaire (SAQ) was used. Total of 503 ED doctors and nurses completed SAQ. Correlation analysis, using Spearman’s Rho, was performed between the number of incidents reported and each dimension of the SAQ. Results The mean score of each SAQ dimension was

Published
2018
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18. Simultaneous evaluation of physical and social environmental correlates of physical activity in adults: A systematic review

Author

Alexia Sawyer, Marcella Ucci, Russell Jones, Lee Smith, and Abi Fisher

Subjects
Active living, Built environment, Social capital, Neighbourhood, Public aspects of medicine, RA1-1270, Social sciences (General), H1-99
Abstract

Background: Ecological models of physical activity posit that social and physical environmental features exert independent and interactive influences on physical activity, but previous research has focussed on independent influences. This systematic review aimed to synthesise the literature investigating how features of neighbourhood physical and social environments are associated with physical activity when both levels of influence are simultaneously considered, and to assess progress in the exploration of interactive effects of social and physical environmental correlates on physical activity. Methods: A systematic literature search was conducted in February 2016. Articles were included if they used an adult (≥15 years) sample, simultaneously considered at least one physical and one social environmental characteristic in a single statistical model, used self-reported or objectively-measured physical activity as a primary outcome, reported findings from quantitative, observational analyses and were published in a peer-reviewed journal. Combined measures including social and physical environment items were excluded as they didn’t permit investigation of independent and interactive social and physical effects. Forty-six studies were identified. Results: An inconsistent evidence base for independent environmental correlates of physical activity was revealed, with some support for specific physical and social environment correlates. Most studies found significant associations between physical activity and both physical and social environmental variables. There was preliminary evidence that physical and social environmental variables had interactive effects on activity, although only 4 studies examined interactive effects. Conclusions: Inconsistent evidence of independent associations between environmental variables and physical activity could be partly due to unmeasured effect modification (e.g. interactive effects) creating unaccounted variance in relationships between the environment and activity. Results supported multiple levels of environmental influence on physical activity. It is recommended that further research uses simultaneous or interaction analyses to gain insight into complex relationships between neighbourhood social and physical environments and physical activity, as there is currently limited research in this area.

Published
2017
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19. Continuous Glucose Monitoring by Insulin-Treated Pilots Flying Commercial Aircraft Within the ARA.MED.330 Diabetes Protocol: A Preliminary Feasibility Study

Author

Garden, Gillian L., primary, Shojaee-Moradie, Fariba, additional, Hutchison, Ewan J., additional, Frier, Brian M., additional, Shaw, Kenneth M., additional, Heller, Simon R., additional, Koehler, Gerd, additional, Mader, Julia K., additional, Maher, Declan, additional, Roberts, Graham A., additional, and Russell-Jones, David L., additional

Published
2023
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20. Modeling coastal flood risk and adaptation response under future climate conditions

Author

Mark Lorie, James E. Neumann, Marcus C. Sarofim, Russell Jones, Radley M. Horton, Robert E. Kopp, Charles Fant, Cameron Wobus, Jeremy Martinich, Megan O'Grady, and Lauren E. Gentile

Subjects
Sea level rise, Coastal flooding, Adaptation, Meteorology. Climatology, QC851-999
Abstract

The National Coastal Property Model (NCPM) simulates flood damages resulting from sea level rise and storm surge along the contiguous U.S. coastline. The model also projects local-level investments in a set of adaptation measures under the assumption that these measures will be adopted when benefits exceed the costs over a 30-year period. However, it has been observed that individuals and communities often underinvest in adaptive measures relative to standard cost-benefit assumptions due to financial, psychological, sociopolitical, and technological factors. This study applies an updated version of the NCPM to incorporate improved cost-benefit tests and to approximate observed sub-optimal flood risk reduction behavior. The updated NCPM is tested for two multi-county sites: Virginia Beach, VA and Tampa, FL. Sub-optimal adaptation approaches slow the implementation of adaptation measures throughout the 100-year simulation and they increase the amount of flood damages, especially early in the simulation. The net effect is an increase in total present value cost of $1.1 to $1.3 billion (2015 USD), representing about a 10% increase compared to optimal adaptation approaches. Future calibrations against historical data and incorporation of non-economic factors driving adaptation decisions could prove useful in better understanding the impacts of continued sub-optimal behavior.

Published
2020
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21. Safety Attitudes among Doctors and Nurses in an Emergency Department of an Australian Hospital

Author

Naif Alzahrani, Russell Jones, and Mohamed E Abdel-Latif

Subjects
patient safety, patient safety climate, quality improvement, team-work, Medicine
Abstract

Introduction: Safety attitudes have been investigated in a number of countries across different hospital departments, however there are few studies including Emergency Departments. Aim: To investigate doctors’ and nurses’ attitudes towards patient safety in Emergency Department in an Australian hospital. Materials and Methods: A cross-sectional research design was used. The participants included 51 doctors and nurses who completed a Safety Attitudes Questionnaire (SAQ) and reported the number of errors they had witnessed over the last year. Multivariate and univariate analysis was used to compare mean subscale scores of safety attitudes between doctors vs. nurses. Results: The findings showed doctors had comparatively positive safety attitudes compared to nurses, who rated teamwork climate, safety climate, unit management and work conditions particularly low. Both doctors and nurses had low opinions of hospital management and working conditions. Doctors and nurses with longer tenures and those who reported a higher number of medical errors had good safety attitudes. Conclusion: This study provides an insight into the safety attitudes of doctors and nurses employed in an Emergency Department in an Australian hospital. Further investigation into the relationship between safety attitudes, error rates and reporting should be performed in future studies.

Published
2019
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23. Intrapulmonary shunting is a key contributor to hypoxia in COVID-19: An update on the pathophysiology

Author

Mayor, Nikhil, primary, Knights, Harry, additional, Kotwica, Aleksandra, additional, Coppola, Andrew Solomon Joseph, additional, Hunter, Harriet, additional, Jeffreys, Nathan, additional, Morgan, Alexander, additional, Gupta, Shivani, additional, Prentice, James, additional, Macfarlane, Rebecca, additional, Russell-Jones, Emma, additional, Dassios, Theodore, additional, and Russell-Jones, David, additional

Published
2022
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25. An innovation in child health: Globally reaching out to child health professionals

Author

Russell Jones, Kathryn Currow, Mary Kwong, and Pramila Menon

Subjects
Child health, pediatrics, global health, health education, Medicine (General), R5-920
Abstract

Worldwide deaths of children younger than 5 years reduced from 12.7 million in 1990 to 6.3 million in 2013. Much of this decline is attributed to an increase in the knowledge, skills, and abilities of child health professionals. In turn this increase in knowledge, skills, and abilities has been brought about by increased child-health-focused education available to child health professionals. Therefore child-health-focused education must be part of the strategy to eliminate the remaining 6.3 million deaths and to achieve the United Nations Millennium Development Goals. This article describes a child-health-focused program that was established in 1992 and operates in 20 countries: Australia, Bangladesh, Botswana, Cambodia, China, Ethiopia, Hong Kong, India, Kenya, Malawi, Mongolia, Myanmar, Sierra Leone, the Seychelles, the Solomon Islands, Tanzania, Tonga, Vanuatu, Vietnam, and Zimbabwe. The Diploma in Child Health/International Postgraduate Paediatric Certificate (DCH/IPPC) course provides a comprehensive overview of evidence-based current best practice in pediatrics. This includes all subspecialty areas from infectious diseases and emergency medicine through to endocrinology, respiratory medicine, neurology, nutrition, and dietetics. Content is developed and presented by international medical experts in response to global child health needs. Content is provided to students via a combination of learning outcomes, webcasts, lecture notes, personalized study, tutorials, case studies, and clinical practice. One hundred eleven webcasts are provided, and these are updated annually. This article includes a brief discussion of the value and focus of medical education programs; a description of the DCH/IPPC course content, approaches to teaching and learning, course structure and the funding model; the most recent evaluation of the DCH/IPPC course; and recommendations for overcoming the challenges for implementing a multinational child-health-focused program.

Published
2016
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27. The Transcription Factors TFEB and TFE3 Link the FLCN-AMPK Signaling Axis to Innate Immune Response and Pathogen Resistance

Author

Leeanna El-Houjeiri, Elite Possik, Tarika Vijayaraghavan, Mathieu Paquette, José A. Martina, Jalal M. Kazan, Eric H. Ma, Russell Jones, Paola Blanchette, Rosa Puertollano, and Arnim Pause

Subjects
Biology (General), QH301-705.5
Abstract

Summary: TFEB and TFE3 are transcriptional regulators of the innate immune response, but the mechanisms regulating their activation upon pathogen infection are poorly elucidated. Using C. elegans and mammalian models, we report that the master metabolic modulator 5′-AMP-activated protein kinase (AMPK) and its negative regulator Folliculin (FLCN) act upstream of TFEB/TFE3 in the innate immune response, independently of the mTORC1 signaling pathway. In nematodes, loss of FLCN or overexpression of AMPK confers pathogen resistance via activation of TFEB/TFE3-dependent antimicrobial genes, whereas ablation of total AMPK activity abolishes this phenotype. Similarly, in mammalian cells, loss of FLCN or pharmacological activation of AMPK induces TFEB/TFE3-dependent pro-inflammatory cytokine expression. Importantly, a rapid reduction in cellular ATP levels in murine macrophages is observed upon lipopolysaccharide (LPS) treatment accompanied by an acute AMPK activation and TFEB nuclear localization. These results uncover an ancient, highly conserved, and pharmacologically actionable mechanism coupling energy status with innate immunity. : El-Houjeiri et al. show that loss of FLCN or pharmacological activation of AMPK induces TFEB/TFE3-dependent pro-inflammatory cytokine expression and phagocytosis in macrophages and confers pathogen resistance in C. elegans. These results uncover an ancient, highly conserved, and pharmacologically actionable mechanism coupling energy status to innate immunity. Keywords: TFEB, TFE3, FLCN, AMPK, innate immune response, pathogen resistance, autophagy, lysosomal biogenesis, phagocytosis

Published
2019
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29. Efficacy of <scp>iGlarLixi</scp> in adults with type 2 diabetes inadequately controlled ( <scp>glycated haemoglobin ≥8%,</scp> ≥64 mmol/mol) on two oral antidiabetes drugs: Post hoc analysis of the <scp>LixiLan‐O</scp> randomized trial

Author

Karen Palmer, Elisabeth Souhami, Julio Rosenstock, Elisabeth Niemoeller, Chen Ji, David Russell-Jones, Melanie J. Davies, Neil Skolnik, and Amar Ali

Subjects
medicine.medical_specialty, endocrine system diseases, Insulin glargine, business.industry, Endocrinology, Diabetes and Metabolism, nutritional and metabolic diseases, Type 2 diabetes, medicine.disease, Gastroenterology, law.invention, Metformin, Lixisenatide, chemistry.chemical_compound, Endocrinology, Postprandial, chemistry, Randomized controlled trial, law, Internal medicine, Mole, Post-hoc analysis, Internal Medicine, medicine, business, medicine.drug
Abstract

AIMS To assess the efficacy and safety of iGlarLixi (the titratable fixed-ratio combination of insulin glargine 100 U/mL [iGlar] plus lixisenatide [Lixi]), in adults with type 2 diabetes (T2D) with glycated haemoglobin (HbA1c) levels ≥8% (≥64 mmol/mol). MATERIALS AND METHODS The LixiLan-O study (NCT02058147) compared iGlarLixi with iGlar or Lixi in adults with T2D inadequately controlled on metformin ± a second oral antidiabetes drug (OAD). This exploratory analysis evaluated the LixiLan-O subgroup of participants with baseline HbA1c levels of ≥8% (≥64 mmol/mol) who were receiving metformin plus a second OAD at screening. RESULTS The mean diabetes duration was 10.0 years, and the mean duration of second OAD use was 4.5 years. iGlarLixi demonstrated greater mean reductions from baseline in HbA1c and 2-hour postprandial glucose (PPG) compared with iGlar or Lixi (HbA1c -1.9% vs. -1.6% or -1.0% [-20 vs. -17 or -10 mmol/mol; 2-hour PPG -7.2 vs. -4.6 or -5.5 mmol/L). Greater proportions of participants achieved HbA1c

Published
2021
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32. Future of offices: app vs in-person.

Author

Gorman, James, Atherton, Tim, Burn, Henry, Brennan, Nick, Stephens, Matt, Russell-Jones, Charlie, Mercer, Andrew, Saunders, Andrew, and Flaherty, Mel

Subjects
OFFICES, LEASES, GENERATIVE artificial intelligence
Abstract

This article discusses the impact of technology on the office leasing sector and the role of humans in the process. The panel of experts agrees that technology has become increasingly important in delivering customer service, but there is still a place for the human factor in finding and leasing office space. While technology can provide efficiency and data gathering capabilities, humans bring emotional understanding and subjective decision-making to the table. The experts believe that technology will continue to play a significant role in the industry, but humans will not be fully replaced. [Extracted from the article]

Published
2024

42. City-level vulnerability to temperature-related mortality in the USA and future projections: a geographically clustered meta-regression

Author

Dave M Mills, Marcus C. Sarofim, Russell Jones, Claire R Lay, Patrick L. Kinney, Alina Vodonos Zilberg, and Joel Schwartz

Subjects
Hot Temperature, Health (social science), Climate Change, Vulnerability, Medicine (miscellaneous), Climate change, 010501 environmental sciences, 01 natural sciences, Extreme heat, 03 medical and health sciences, 0302 clinical medicine, Effects of global warming, Humans, Meta-regression, 030212 general & internal medicine, Cities, Mean radiant temperature, Extreme Cold, 0105 earth and related environmental sciences, Excess mortality, Health Policy, Temperature, Public Health, Environmental and Occupational Health, Extreme Heat, United States, Geography, Demography
Abstract

Summary Background Extreme heat exposure can lead to premature death. Climate change is expected to increase the frequency, intensity, and duration of extreme heat events, resulting in many additional heat-related deaths globally, as well as changing the nature of extreme cold events. At the same time, vulnerability to extreme heat has decreased over time, probably due to a combination of physiological, behavioural, infrastructural, and technological adaptations. We aimed to account for these changes in vulnerability and avoid overstated projections for temperature-related mortality. We used the historical observed decrease in vulnerability to improve future mortality estimates. Methods We used historical mortality and temperature data from 208 US cities to quantify how observed changes in vulnerability from 1973 to 2013 affected projections of temperature-related mortality under various climate scenarios. We used geographically structured meta-regression to characterise the relationship between temperature and mortality for these urban populations over the specified time period. We then used the fitted relationships to project mortality under future climate conditions. Findings Between Oct 26, 2018, and March 9, 2020, we established that differences in vulnerability to temperature were geographically structured. Vulnerability decreased over time in most areas. US mortalities projected from a 2°C increase in mean temperature decreased by more than 97% when using 2003–13 data compared with 1973–82 data. However, these benefits declined with increasing temperatures, with a 6°C increase showing only an 84% decline in projected mortality based on 2003–13 data. Interpretation Even after accounting for adaptation, the projected effects of climate change on premature mortality constitute a substantial public health risk. Our work suggests large increases in temperature will require additional mitigation to avoid excess mortality from heat events, even in areas with high air conditioning coverage in place. Funding The US Environmental Protection Agency and Abt Associates.

Published
2021
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43. HbA1c and hypoglycaemia outcomes for people with type 1 diabetes due to the introduction of a single-day structured education programme and flash glucose monitoring

Author

Helen Griffith, David W Hunt, Karen Mackie, Roselle Herring, Gillian Garden, Beverly Tuthill, and David Russell-Jones

Subjects
medicine.medical_specialty, Type 1 diabetes, Health professionals, business.industry, Diabetes mellitus, Internal medicine, medicine, Subgroup analysis, Distress screening, General Medicine, medicine.disease, business, Structured education
Abstract

People with type 1 diabetes who met NHS England funding criteria attended an accredited, intensive one-day structured education programme and completed the online FreeStyle Libre Academy training module followed by a 30-minute healthcare professional face-to-face practical training session. HbA1c, Gold hypoglycaemia score and Diabetes Distress Screening score were documented before commencement of the intervention and at 6 months. 213 people with type 1 diabetes (52% men; average age 48 years (range 18–87)) completed the 6-month intervention. Overall mean HbA1c reduced by 6 mmol/mol (0.5%) from 62±14 mmol/mol (7.8%) to 56±12 mmol/mol (7.3%) (p

Published
2021
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45. Vitamin B12 Transporters

Author

Russell-Jones, Gregory J., Alpers, David H., Borchardt, Ronald T., editor, Amidon, Gordon L., editor, and Sadée, Wolfgang, editor

Published
2002
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47. Rationale and design of the phase 3a development programme (ONWARDS 1-6 trials) investigating once-weekly insulin icodec in diabetes

Author

Athena Philis‐Tsimikas, Harpreet S. Bajaj, Kamilla Begtrup, Roman Cailleteau, Amoolya Gowda, Ildiko Lingvay, Chantal Mathieu, David Russell‐Jones, and Julio Rosenstock

Subjects
Endocrinology, Endocrinology, Diabetes and Metabolism, Internal Medicine
Abstract

To describe the phase 3a ONWARDS clinical development programme investigating insulin icodec (icodec), a once-weekly basal insulin, including the design and rationale for each of the ONWARDS 1-6 trials.Six randomized controlled trials have been initiated in adults with type 2 diabetes (T2D) (insulin-naive: ONWARDS 1, 3 and 5; previously insulin-treated: ONWARDS 2 and 4) and type 1 diabetes (T1D) (ONWARDS 6). Each trial will investigate icodec use in a unique clinical scenario, with consideration of long-term safety and varied comparator treatments (insulin glargine U100 or U300 or insulin degludec). ONWARDS 5 will incorporate real-world elements and a digital dose titration solution to guide icodec dosing. The primary objective for each of the trials is to compare the change in HbA1c from baseline to week 26 or week 52 between icodec and comparator arms. Secondary objectives include investigating other glycaemic control and safety parameters, such as fasting glucose, time in glycaemic range and hypoglycaemia. Patient-reported outcomes will assess treatment satisfaction.The ONWARDS 1-6 trials will evaluate the efficacy and safety of once-weekly icodec compared with currently available daily basal insulin analogues in T2D and T1D. These trials will generate comprehensive evidence of icodec use in diverse populations across the spectrum of diabetes progression and treatment experience.

Published
2022

49. Effect of dapagliflozin on cardiac function and metabolic and hormonal responses to exercise

Author

Roselle A Herring, Iain Parsons, Fariba Shojaee-Moradie, Mary Stevenage, Nicola Jackson, Ralph Manders, A Margot Umpleby, Barbara A Fielding, Melanie Davies, and David L Russell-Jones

Subjects
Endocrinology, Endocrinology, Diabetes and Metabolism, Biochemistry (medical), Clinical Biochemistry, Biochemistry
Abstract

Objective This work aimed to investigate the effect of the SGLT2 inhibitor, dapagliflozin (DAPA), on cardiac function and the metabolic and hormonal response to moderate exercise in people with type 2 diabetes. Methods This was a double-blind, placebo-controlled crossover study with a 4-week washout period. Nine participants were randomly assigned to receive either 4 weeks of DAPA or 4 weeks of placebo. After each treatment, they underwent an exercise protocol with 2 consecutive 10-minute stages at a constant load corresponding to 40% and 70% maximal oxygen consumption (VO2max), coupled with hormonal and metabolic analysis. A blinded transthoracic echocardiogram was performed 3 days later. Results During the exercise protocol, glucose and lactate were lower (P < .0001 and P < .05, respectively) and β-hydroxybutyrate (BOBH) and growth hormone (GH) were higher (P < .0005 and P = .01) following DAPA treatment compared to placebo. There was a trend for lower insulin with DAPA. Adrenalin, noradrenalin, and glucagon were not different. Following DAPA participants demonstrated an increased mean peak diastolic mitral annular velocity (e’) in comparison to placebo (P = .03). The indexed left atrial volume and right ventricular e” were reduced following DAPA compared with placebo (P = .045 and P = .042, respectively). Arterial stiffness was not different between treatments (DAPA 9.35 ± 0.60 m/s; placebo 9.07 ± 0.72 m/s). Conclusion During exercise, GH may be more important than catecholamines in driving the shift from glucose to fatty acid metabolism by SGLT2 inhibitors. The 4-week crossover design showed changes in cardiac function were rapid in onset and reversible.

Published
2022

50. Radiation, Clouds, and Self-Aggregation in RCEMIP Simulations

Author

Kieran Nicholas Pope, Christopher E Holloway, Todd Russell Jones, and Thorwald Hendrik Matthias Stein

Abstract

This dataset includes the numpy arraysused inplotting the figures in the paper: "Radiation, Clouds, and Self-Aggregation in RCEMIP Simulations". Each zipped file contains the arrays used to create one figure. The units are always SI. A description of the format of each array is given below. Fig01 "_cloud_components_for_.npy" Has shape (n_cloud_types, n_CRMs) Cloud types are in the same order as displayed on the x-axis of the figure. CRMs are in order of those displayed in figure 3. DAM and MESONH are missing due to not having 3D data. Fig02 "__cloud_fraction_vs_FMSE.npy" Shape = (100, ) 100 FMSE percentiles from 0 to 99, 4 or 8 cloud types depending on the cloud scheme. Value shows fraction of cloud type at that FMSE percentile. Fig03 & Fig04 "__var_normFMSE.npy" Time series of var(hn) without any smoothing in time. First 2 days (8 time steps) are not included. Fig05 "___budget-terms.npy" Shape = (5, n_models) First dimension is var(hn) term, LW term, SW term, SEF term, Advection term. Models are in order of those shown in figures 3 and 4 depending on the model_type. "___budget-terms_ClearSky.npy" Shape = (2, n_models) First dimension is LW term, SW term. Fig06 Each subplot can be made by plotting the arrays on either the x or y axis. Fig07 & Fig08 "___.npy" shape = (4, n_models) first dimension is the cloud types: Clear, Shallow, Other, Deep models in the same order as shown in figures 3 or 4 depending on the model_type. &nbsp

Published
2022
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