232 results on '"A. Nuccorini"'
Search Results
2. Coronary Artery By-Pass Grafting in Patient With Paroxysmal Nocturnal Hemoglobinuria (Case Report)
- Author
-
A. Amendola, G. Paternoster, S. P Pascale, R. Nuccorini, M. D'Amora, G. Pittella, R. D'Ascoli, F. Prestipino, G. Luzi, and M. Pizzuti
- Subjects
paroxysmal nocturnal haemoglobinuria ,eculizumab ,thromboelastogram ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Paroxysmal nocturnal haemoglobinuria (PNH) is a clonal haematopoietic stem cell disease that presents with haemolytic anaemia, thrombosis and bone marrow failure. We report a case of a 51-year-old male with a history of PNH in treatment with Eculizumab admitted to our Hospital for acute chest pain and dyspnoea. The diagnosis was a triple vessel disease and patient was scheduled for coronary artery bypass grafting surgery. To balance the risk between thrombosis and bleeding in this particular clinical setting, we decided to use thromboelastography (TEG) as point of care solution and we used the R parameter as the target of our anticoagulant therapy. The R parameter between 11 and 14 sec can be used as a target value to balance the risk; in addition, there was no evidence of acute hemolysis during the surgery and supplemental dose of Eculizumab was administered in order to minimize any potential exacerbation of intravascular hemolysis.
- Published
- 2021
- Full Text
- View/download PDF
3. Evaluation of serological response to anti-SARS-CoV-2 mRNA vaccination in hematological patients
- Author
-
Sara Pasquina Pascale, Roberta Nuccorini, Teresa Pierri, Roberta Di Mare, Lucia Fabio, Emilia Lerose, Maria Antonietta Merlino, Pietro Schiavo, Angela Amendola, Gino Brucoli, Maria Denise Caputo, Ida Chitarrelli, Michele Cimminiello, Sabrina Coluzzi, Nunzio Biagio Filardi, Angela Matturro, Domenico Vertone, Monica Poggiaspalla, Francesco Malaspina, Gerardo Musuraca, Gennaro Coralluzzo, Clara Mannarella, Clelia Musto, Angela Pia Bellettieri, Giovanni Martinelli, Claudio Cerchione, and Michele Pizzuti
- Subjects
SARS-COV-2 ,mRNA vaccination ,anti-spike IgG ,hematological malignancies ,onco-hematology ,Immunologic diseases. Allergy ,RC581-607 - Abstract
IntroductionIn immunocompromised patients, SARS-CoV-2 mRNA vaccine has been used in Italy from the beginning of the vaccination campaign, but several studies have shown that the serological response of onco-hematological patients was reduced compared to healthy subjects, due to the state of immunosuppression because of both underlying disease and administered therapy.MethodsWe evaluated the association of anti-SARS-CoV-2 spike IgG titers in 215 hematological patients with clinical and demographic variables to verify if it was possible to identify predictive parameters of serological response, as well as using a control group, consisting of healthy health workers of San Carlo Hospital in Potenza. Anti-SARS-CoV2 IgG titers were evaluated after 30–45 days post second dose vaccine using chemiluminescent microparticle immunoassay technology.ResultsPatients with hematological malignancies, compared with the control arm, had both a mean concentration of anti-SARS-CoV-2 IgG significantly lower and a seroconversion rate numerically lower. All chronic lymphatic leukemia patients showed levels of antibody titer below the mean concentration, also in only clinical surveillance patients. Comparing serological response in hematological malignancies, only acute leukemia patients who were off therapy had the highest seroconversion rate among the patients’ cohorts and a mean antibody concentration greater than the control arm. Patients treated with steroids and rituximab showed a lower level of anti-SARS-CoV-2 spike IgG. Differences in anti-spike IgG levels among chronic myeloid leukemia patients stratified according to tyrosine kinase inhibitor therapy and molecular response were observed, and they could have interesting implications on the evaluation of the effects of these drugs on the immune system, but having not reached statistical significance at the moment. The cohort of patients who received a stem cell transplant was very heterogeneous because it included different hematological malignancies and different types of transplant; however, a mean concentration of anti-SARS-CoV2 IgG greater than the control arm was reported. Indeed, among patients who performed a transplant for over 6 months only one had a spike IgG concentration below the cutoff.ConclusionsOur data confirm reduced serological response in hematological patients after anti-SARS-CoV-2 vaccination. However, we found a great diversity of SARS-CoV-2 antibody response according to types of pathologies and therapies.
- Published
- 2022
- Full Text
- View/download PDF
4. Nilotinib in steroid-refractory cGVHD: prospective parallel evaluation of response, according to NIH criteria and exploratory response criteria (GITMO criteria)
- Author
-
Olivieri, A., Mancini, G., Olivieri, J., Marinelli Busilacchi, E., Cimminiello, M., Pascale, S. P., Nuccorini, R., Patriarca, F., Corradini, P., Bacigalupo, A., Angelini, S., Poloni, A., Grillo, G., Onida, F., Martino, M., Di Renzo, N., Nagler, A., Mordini, N., Bruno, B., Ciceri, F., and Bonifazi, F.
- Published
- 2020
- Full Text
- View/download PDF
5. Culture in the OED online Phrases and Quotations
- Author
-
Nuccorini, Stefania, primary
- Published
- 2023
- Full Text
- View/download PDF
6. Predicting failure of hematopoietic stem cell mobilization before it starts: the predicted poor mobilizer (pPM) score
- Author
-
Olivieri, Jacopo, Attolico, Immacolata, Nuccorini, Roberta, Pascale, Sara Pasquina, Chiarucci, Martina, Poiani, Monica, Corradini, Paolo, Farina, Lucia, Gaidano, Gianluca, Nassi, Luca, Sica, Simona, Piccirillo, Nicola, Pioltelli, Pietro Enrico, Martino, Massimo, Moscato, Tiziana, Pini, Massimo, Zallio, Francesco, Ciceri, Fabio, Marktel, Sarah, Mengarelli, Andrea, Musto, Pellegrino, Capria, Saveria, Merli, Francesco, Codeluppi, Katia, Mele, Giuseppe, Lanza, Francesco, Specchia, Giorgina, Pastore, Domenico, Milone, Giuseppe, Saraceni, Francesco, Di Nardo, Elvira, Perseghin, Paolo, and Olivieri, Attilio
- Published
- 2018
- Full Text
- View/download PDF
7. English dictionary criticism in two lexicographical specialist journals
- Author
-
Nuccorini, Stefania, primary
- Published
- 2017
- Full Text
- View/download PDF
8. Expression of some ATP-binding cassette transporters in acute myeloid leukemia
- Author
-
Antonella Maria Salvia, Flavia Cuviello, Sabrina Coluzzi, Roberta Nuccorini, Immacolata Attolico, Sara Pasquina Pascale, Faustino Bisaccia, Michele Pizzuti, and Angela Ostuni
- Subjects
Acute Myeloid Leukemia ,Multidrug Resistance ,ABC transporters ,ABCC6 ,Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
Hematopoietic cells express ATP binding cassette (ABC) transporters in relation to different degrees of differentiation. One of the known multidrug resistance mechanisms in acute myeloid leukemia (AML) is the overexpression of efflux pumps belonging to the superfamily of ABC transporters such as ABCB1, ABCG2 and ABCC1. Although several studies were carried out to correlate ABC transporters expression with drug resistance, little is known about their role as markers of diagnosis and progression of the disease. For this purpose we investigated the expression, by real-time PCR, of some ABC genes in bone marrow samples of AML patients at diagnosis and after induction therapy. At diagnosis, ABCG2 was always down-regulated, while an up regulated trend for ABCC1 was observed. After therapy the examined genes showed a different expression trend and approached the values of healthy subjects suggesting that this event could be considered as a marker of AML regression. The expression levels of some ABC transporters such as ABCC6, seems to be related to gender, age and to the presence of FLT3/ITD gene mutation.
- Published
- 2017
- Full Text
- View/download PDF
9. The lexicographic treatment of representative samples of English and Italian collocations
- Author
-
Stefania Nuccorini, Ersilia Incelli, Renzo Mocini, Judith Turnbull, and Nuccorini, Stefania
- Published
- 2022
10. Long-term outcome and prospective validation of NIH response criteria in 39 patients receiving imatinib for steroid-refractory chronic GVHD
- Author
-
Olivieri, Attilio, Cimminiello, Michele, Corradini, Paolo, Mordini, Nicola, Fedele, Roberta, Selleri, Carmine, Onida, Francesco, Patriarca, Francesca, Pavone, Enzo, Svegliati, Silvia, Gabrielli, Armando, Bresciani, Paola, Nuccorini, Roberta, Pascale, Sara, Coluzzi, Sabrina, Pane, Fabrizio, Poloni, Antonella, Olivieri, Jacopo, Leoni, Pietro, and Bacigalupo, Andrea
- Published
- 2013
- Full Text
- View/download PDF
11. Evaluation of serological response to anti-SARS-CoV-2 mRNA vaccination in hematological patients
- Author
-
Pascale, Sara Pasquina, primary, Nuccorini, Roberta, additional, Pierri, Teresa, additional, Di Mare, Roberta, additional, Fabio, Lucia, additional, Lerose, Emilia, additional, Merlino, Maria Antonietta, additional, Schiavo, Pietro, additional, Amendola, Angela, additional, Brucoli, Gino, additional, Caputo, Maria Denise, additional, Chitarrelli, Ida, additional, Cimminiello, Michele, additional, Coluzzi, Sabrina, additional, Filardi, Nunzio Biagio, additional, Matturro, Angela, additional, Vertone, Domenico, additional, Poggiaspalla, Monica, additional, Malaspina, Francesco, additional, Musuraca, Gerardo, additional, Coralluzzo, Gennaro, additional, Mannarella, Clara, additional, Musto, Clelia, additional, Bellettieri, Angela Pia, additional, Martinelli, Giovanni, additional, Cerchione, Claudio, additional, and Pizzuti, Michele, additional
- Published
- 2022
- Full Text
- View/download PDF
12. The didactic purposes of John Millhouse’s Italian English, English-Italian New Pronouncing and Explanatory Dictionary
- Author
-
Stefania Nuccorini and Nuccorini, Stefania
- Subjects
19th century English-Italian dictionary, didactic material, lexicographic treament - Abstract
John Millhouse published his Corso graduato e completo di lingua inglese in 1842, and a few years later his italian-english, english-italian new Pronouncing and explanatory Dictionary: vol. 1 in 1849, and vol. 2 in 1853. Though the Corso and the Dictionary were not originally meant to be used together by Italian learners of English, Millhouse soon revised his own original pronunciation system, so that both the Dictionary and the Corso would present the same sound keys. This article outlines the explanatory framework of his pronunciation system and analyses the Dictionary’s role in helping students translate from and into English, by comparing selected lexical equivalents, taken from the Corso passages, with their Dictionary equivalents, to highlight (a)symmetries between their contextualized use and their lexicographic treatment.
- Published
- 2021
13. Martina Nied Curcio / Stefania Nuccorini / Paolo Vaciago, 'Alle Wege führen nach Rom…': Der Europäische Master für Lexikographie (EMLex) zu Gast an der Università degli Studi Roma Tre
- Author
-
Stefania Nuccorini, Paolo Vaciago, and Martina Nied Curcio
- Published
- 2019
- Full Text
- View/download PDF
14. English Lexicography in Time. An Introduction
- Author
-
Stefania Nuccorini and Nuccorini, Stefania
- Subjects
History, English, Lexicography - Published
- 2020
15. English Lexicography in Time: Social and Cultural Issues. An Introduction'
- Author
-
stefania nuccorini and Nuccorini, Stefania
- Abstract
non presente
- Published
- 2020
16. Usage, Authority and Stance in the Lexicographic Management of English
- Author
-
Stefania Nuccorini and Nuccorini, Stefania
- Subjects
usage, authority, stance, descriptivism, prescriptivism, lexicography - Abstract
This paper deals with the concepts of usage, authority and stance in the field of lexicography, with special reference to the first edition of Webster’s Third New International Dictionary of the English Language (W3), the Oxford English Dictionary (OED), and different editions of learner’s dictionaries up to the latest ones. The main aim is to compare and assess different dictionary-making policies and their outcomes on the basis of the more or less overt role played by the interpretations and implementations of the above-mentioned concepts of usage, authority and stance and their interconnections with descriptivism and prescriptivism. Scholarly approaches to the concepts of usage, authority, and stance are presented in section 1 to outline the scientific background to their pervasiveness in dictionary-making policies. The definitions of the words usage, authority and stance given in W3 and in the OED, whose outstanding positions in the lexicographical field are undisputed, are then analysed in section 2. The related definitions of descriptivism and prescriptivism are compared and their application and instantiation are exemplified by the treatment of woman question (as a lexical item) in the OED, as representative of its historical perspective, and of ain’t in W3, as the symbol of its lexicographic breakthrough (section 3). Section 4 focuses on Learner’s Dictionaries and their specific pedagogical role with reference to usage, authority and stance, and on their definitions of ain’t in different editions, to see if that headword has undergone socio-cultural changes in time. A few concluding remarks are offered in section 5.
- Published
- 2020
17. Lexicographic Metalanguage as (a) Specialized Language
- Author
-
Stefania Nuccorini, Maci Stefania, Sala Michele, Spinzi Cinzia, and Nuccorini, Stefania
- Subjects
metalanguage, Learner's Dictionaries, specialised language, terminology - Abstract
l'abstract non è previto in questa pubblicazione, ma la prima parte dell'introduzione, riportata di seguito, equivale a un aabstract This contribution analyses the features that allow the conventionalized system(s) used to present and describe different types of information in lexicographic products, in particular English monolingual Learner’s Dictionaries (LDs), to qualify as metalanguage and as a particular form of specialized language. In general, the concept of metalanguage partakes of some of the constitutive elements of specialized language and of terminology, but the linguistic status and the purposes of lexicographic metalanguage present specific metalinguistic features. This article will evaluate differences and similarities in the metalanguages adopted in different editions of three LDs, namely, in alphabetical order, the Collins Cobuild English Dictionary1 (COBUILD); the Longman Dictionary of Contemporary English (LDOCE); and the Oxford Advanced Learner’s Dictionary (OALD). The main aim is to assess the extent to which their descriptive, conceptual and communicative role makes it possible to identify each of their metalanguages as (a) specialized language.
- Published
- 2020
18. Digging into a Thesaurus for Treasures: Phraseological Conceptual Maps in the Longman Language Activator
- Author
-
Stefania Nuccorini, Paola Cotta Ramusino, Fabio Mollica, Nuccorini, Stefania, and Cotta Ramusino Paola, Mollkica Fabio
- Subjects
phraseology, conceptual maps, Longman Activator, onomasiological approach ,Frame semantic fields, phraseologisms, concept-words, collocations, idioms - Abstract
The article describes how the conceptual maps of the thesaurus-like Longman Language Activator (1993, 2002) (LLA) allow semantically related phraseologisms to be identified. It analyses selected idioms and collocations taken from the LLA keyword entries WORK, BRAVE, WIN, and ANGRY that are respectively related to the FRAME-project* semantic fields “people and work”, “people and their behaviour”, “human relations” and “emotions”. The aim is to highlight main differences in their use and to show that the LLA could feature as a primary source of the English phraseologisms to be added to the FRAME database. *(FRAseologia Multilingue Elettronica - Electronic Multilin-gual Phraseology).
- Published
- 2020
19. Due esempi di lessicografia bilingue in Inghilterra e in Italia a metà del diciannovesimo secolo autore: Stefania Nuccorini
- Author
-
stefania nuccorini and Nuccorini, Stefania
- Subjects
contesti, apprendimento delle lingue, approcci linguistico-lessicali, trattamento lessicografico. contexts, language learning, linguistic and lexical approaches, lexicographical treatment - Abstract
Il dizionario di Tarver, The Royal Phraseological English-French, French-English Dictionary, in due volumi (vol. 1, 1845; vol. 2, 1849), pubblicati a Londra, e quello di Millhouse, Dizionario Italiano-Inglese, Inglese-Italiano, anch’esso in due volumi (vol. 1, 1849; vol. 2, 1853), usciti a Milano, hanno visto la luce in anni molto vicini e con obiettivi didattici parzialmente comuni: sono entrambi dizionari bilingui, in entrambi è presente la lingua inglese e sono primariamente rivolti a chi studia, rispettivamente, il francese o l’inglese come lingua straniera. Al contempo sono diversi per struttura e contenuti: il dizionario di Tarver è specialistico, come evidenziato dalla parola ‘phraseological’ fin dal titolo, mentre quello di Millhouse ha scopi generali, anche se è incentrato sulla pronuncia dell’inglese. Le differenze sono in parte dovute ai contesti in cui sono stati prodotti, legati all’insegnamento del francese in Inghilterra e a quello dell’inglese in Italia, e in parte ad approcci linguistico-lessicali e lessicografici più o meno legati alle rispettive tradizioni. La breve analisi delle voci hand e main in Tarver e di hand e mano in Millhouse evidenzia come le modalità di presentazione e di trattamento delle entrate rispondono ai rispettivi obiettivi. Tarver’s Royal Phraseological French-English, English-French Dictionary (vol. 1, 1845; vol. 2, 1849) and Milhouse’s Dizionario Italiano-Inglese, Inglese-Italiano (vol. 1, 1849; vol. 2, 1853) were published at a short distance from each another, respectively in London and in Milan. They are both two-volume bilingual dictionaries which include English, and they partly share their didactic aims: they primarily address learners of French or English respectively as a foreign language. However, their structure and contents differ. Tarver’s dictionary is specialised, as the word ‘phraseology’ shows in the title itself, while Millhouse’s dictionary is a general-purpose one, though with a special focus on English pronunciation. Differences partly depend on their production situational contexts, with reference to French learning in England as opposed to English learning in Italy, and partly on the respective linguistic, lexical, and lexicographic traditions behind their approaches. A brief comparative analysis of the entries hand and main in Tarver’s dictionary and of hand and mano in Millhouse’s one is meant to show if and how their presentation modes and treatment meet their authors’ (and prospective users’) aims.
- Published
- 2020
20. VALIDATION IN A MULTICENTER SETTING OF GITMO CRITERIA FOR IDENTIFICATION OF THE POOR MOBILIZER IN MULTIPLE MYELOMA (MM) AND LYMPHOMA PATIENTS: PRELIMINARY ANALYSIS ON 312 PATIENTS: PH-O089
- Author
-
Attolico, I., Di Nardo, E., Nuccorini, R., Chiarucci, M., Nassi, L., Mengarelli, A., Capria, S., Ciceri, F., Martino, M., Piccirillo, N., Pascale, S., Pizzuti, M., and Olivieri, A.
- Published
- 2014
21. «On le peut, je l’essaie: un plus savant le fasse». Le novità di un dizionario fraseologico inglese-francese, francese-inglese di metà ‘800
- Author
-
Nuccorini , Stefania
- Abstract
Il verso di La Fontaine, tratto da Contre ceux qui ont le goût difficile del 1668, è incluso come esergo nel frontespizio e ripetuto come motto ispiratore nella prefazione del secondo volume, francese-inglese, del Royal Phraseological English-French, French-English Dictionary, pubblicato nel 1849, quattro anni dopo il primo volume, inglese-francese. John Charles Tarver, l’autore del dizionario, docente di francese a Eton fin dal 1826, ne ha fatto un’opera innovativa nel panorama della lessicografia inglese-francese dell’epoca, basandosi sulla sua lunga esperienza didattica, sulla padronanza di entrambe le lingue e relative culture e, in particolare, sul riconoscimento del ruolo fondante della fraseologia nell’apprendimento e nell’uso effettivo di una lingua straniera. Al fine di mostrare la rilevanza del dizionario all’epoca e il suo ruolo innovativo, il contributo illustrerà il contesto in cui fu prodotto e analizzerà i tratti salienti delle combinazioni fraseologiche che ne costituiscono l’essenza e la loro modalità di presentazione in voci selezionate da entrambi i volumi., Allegretto Vivace. Omaggio a Bruna Donatelli
- Published
- 2021
- Full Text
- View/download PDF
22. SPLENIC INCREASED 18F‐FDG UPTAKE IN PET SCAN PERFORMED FOLLOWING TREATMENT WITH PEG‐GCSF LIPEFILGASTRIM
- Author
-
Fe', A., primary, Cimminiello, M., additional, Nicoletti, A., additional, Matturro, A., additional, Coralluzzo, G., additional, Pascale, S. P., additional, Nuccorini, R., additional, Fabio, L., additional, Mancino, S., additional, and Cavallo, T., additional
- Published
- 2021
- Full Text
- View/download PDF
23. Coronary Artery By-Pass Grafting in Patient With Paroxysmal Nocturnal Hemoglobinuria (Case Report)
- Author
-
A. Amendola ; Hematology and HSC Transplant Center, G. Paternoster ; Department of Cardiac Surgery and Cardiovascular Intensive Care Azienda Ospedaliera Regionale San Carlo, S. Pascale P; Hematology and HSC Transplant Center, R. Nuccorini ; Hematology and HSC Transplant Center, M. D'Amora ; Department of Cardiac Surgery and Cardiovascular Intensive Care Azienda Ospedaliera Regionale San Carlo, G. Pittella ; Department of Cardiac Surgery and Cardiovascular Intensive Care Azienda Ospedaliera Regionale San Carlo, R. D'Ascoli ; Department of Cardiac Surgery and Cardiovascular Intensive Care Azienda Ospedaliera Regionale San Carlo, F. Prestipino ; Department of Cardiac Surgery and Cardiovascular Intensive Care Azienda Ospedaliera Regionale San Carlo, G. Luzi ; Department of Cardiac Surgery and Cardiovascular Intensive Care Azienda Ospedaliera Regionale San Carlo, M. Pizzuti ; Hematology and HSC Transplant Center, А. Амендола ; Центр гематологии и трансплантации гемопоэтических стволовых клеток, Дж. Патерностер ; Областная больница Сан Карло, Отделение сердечной хирургии и сердечно-сосудистой интенсивной терапии, С. Паскале П.; Центр гематологии и трансплантации гемопоэтических стволовых клеток, Р. Нуккорини ; Центр гематологии и трансплантации гемопоэтических стволовых клеток, М. Д'Амора ; Областная больница Сан Карло, Отделение сердечной хирургии и сердечно-сосудистой интенсивной терапии, Дж. Питтелла ; Областная больница Сан Карло, Отделение сердечной хирургии и сердечно-сосудистой интенсивной терапии, Р. Д'Асколи ; Областная больница Сан Карло, Отделение сердечной хирургии и сердечно-сосудистой интенсивной терапии, Ф. Престипино ; Областная больница Сан Карло, Отделение сердечной хирургии и сердечно-сосудистой интенсивной терапии, Дж. Луци ; Областная больница Сан Карло, Отделение сердечной хирургии и сердечно-сосудистой интенсивной терапии, М. Пиццути ; Центр гематологии и трансплантации гемопоэтических стволовых клеток, A. Amendola ; Hematology and HSC Transplant Center, G. Paternoster ; Department of Cardiac Surgery and Cardiovascular Intensive Care Azienda Ospedaliera Regionale San Carlo, S. Pascale P; Hematology and HSC Transplant Center, R. Nuccorini ; Hematology and HSC Transplant Center, M. D'Amora ; Department of Cardiac Surgery and Cardiovascular Intensive Care Azienda Ospedaliera Regionale San Carlo, G. Pittella ; Department of Cardiac Surgery and Cardiovascular Intensive Care Azienda Ospedaliera Regionale San Carlo, R. D'Ascoli ; Department of Cardiac Surgery and Cardiovascular Intensive Care Azienda Ospedaliera Regionale San Carlo, F. Prestipino ; Department of Cardiac Surgery and Cardiovascular Intensive Care Azienda Ospedaliera Regionale San Carlo, G. Luzi ; Department of Cardiac Surgery and Cardiovascular Intensive Care Azienda Ospedaliera Regionale San Carlo, M. Pizzuti ; Hematology and HSC Transplant Center, А. Амендола ; Центр гематологии и трансплантации гемопоэтических стволовых клеток, Дж. Патерностер ; Областная больница Сан Карло, Отделение сердечной хирургии и сердечно-сосудистой интенсивной терапии, С. Паскале П.; Центр гематологии и трансплантации гемопоэтических стволовых клеток, Р. Нуккорини ; Центр гематологии и трансплантации гемопоэтических стволовых клеток, М. Д'Амора ; Областная больница Сан Карло, Отделение сердечной хирургии и сердечно-сосудистой интенсивной терапии, Дж. Питтелла ; Областная больница Сан Карло, Отделение сердечной хирургии и сердечно-сосудистой интенсивной терапии, Р. Д'Асколи ; Областная больница Сан Карло, Отделение сердечной хирургии и сердечно-сосудистой интенсивной терапии, Ф. Престипино ; Областная больница Сан Карло, Отделение сердечной хирургии и сердечно-сосудистой интенсивной терапии, Дж. Луци ; Областная больница Сан Карло, Отделение сердечной хирургии и сердечно-сосудистой интенсивной терапии, and М. Пиццути ; Центр гематологии и трансплантации гемопоэтических стволовых клеток
- Abstract
Paroxysmal nocturnal haemoglobinuria (PNH) is a clonal haematopoietic stem cell disease that presents with haemolytic anaemia, thrombosis and bone marrow failure. We report a case of a 51-year-old male with a history of PNH in treatment with Eculizumab admitted to our Hospital for acute chest pain and dyspnoea. The diagnosis was a triple vessel disease and patient was scheduled for coronary artery bypass grafting surgery. To balance the risk between thrombosis and bleeding in this particular clinical setting, we decided to use thromboelastography (TEG) as point of care solution and we used the R parameter as the target of our anticoagulant therapy. The R parameter between 11 and 14 sec can be used as a target value to balance the risk; in addition, there was no evidence of acute hemolysis during the surgery and supplemental dose of Eculizumab was administered in order to minimize any potential exacerbation of intravascular hemolysis., Пароксизмальная ночная гемоглобинурия (ПНГ) — клональное заболевание гемопоэтических стволовых клеток, которое проявляется гемолитической анемией, тромбозами и недостаточностью функции костного мозга. Пациент мужского пола 51 года с ПНГ в анамнезе, по поводу которой он получал лечение экулизумабом, поступил в больницу с жалобами на острую боль в грудной клетке и одышку. Поставили диагноз трехсосудистого поражения коронарного русла, по поводу чего запланировали проведение аортокоронарного шунтирования. Для того, чтобы избежать развития как тромбоза, так и кровотечения, в данном сложном клиническом случае, решили провести пациенту тромбоэластографическое исследование и использовать параметр R в качестве целевого при проведении антикоагулянтной терапии. При поддержании значений данного параметра в рамках 11-14 сек можно достичь оптимального баланса между риском тромбоза и кровотечения. Кроме того, во время оперативного вмешательства не наблюдали острого гемолиза, а для уменьшения риска развития внутрисосудистого гемолиза дополнительно назначили экулизумаб.
- Published
- 2021
24. Coronary Artery By-Pass Grafting in Patient With Paroxysmal Nocturnal Hemoglobinuria (Case Report)
- Author
-
Amendola, A., primary, Paternoster, G., additional, Pascale, S. P, additional, Nuccorini, R., additional, D'Amora, M., additional, Pittella, G., additional, D'Ascoli, R., additional, Prestipino, F., additional, Luzi, G., additional, and Pizzuti, M., additional
- Published
- 2021
- Full Text
- View/download PDF
25. Bortezomib-including mobilization and conditioning is feasible in elderly multiple myeloma patients and can achieve negativization of the minimal residual disease: P885
- Author
-
Attolico, I., Nuccorini, R., Amendola, A., Cimminiello, C., Fragasso, A., Pascale, S., Coluzzi, S., Scoca, C., Pizzuti, M., Poggiaspalla, M., Vertone, D., Filardi, N., and Olivieri, A.
- Published
- 2011
26. Talking about happiness and sadness: phraseologisms from the Longman Language Activator
- Author
-
Stefania NUCCORINI, Oana-Dana Balaş / Anamaria Gebăilă / Roxana Voicu, and Nuccorini, Stefania
- Subjects
phraseologism, emotion, Longman Language Activator, communicative values - Published
- 2019
27. 'Alle Wege führen nach Rom…': Der Europäische Master für Lexikographie (EMLex) zu Gast an der Università degli Studi Roma Tre
- Author
-
Vaciago Paolo, Nuccorini Stefania, Vaciago, Paolo, and Nuccorini, Stefania
- Subjects
Europäischer Master für Lexikographie, EMLex, Erasmus Mundus Joint Master Degree, EMJMD, Masterstudiengang, lexikographische Module, Master Europeo in Lessicografia, European Master of Lexicography - Abstract
Report of the EMLex summer term at Rome 3 University
- Published
- 2019
28. Italian phraseology
- Author
-
Nuccorini, Stefania, primary
- Published
- 2007
- Full Text
- View/download PDF
29. 7.4 Towards an ‘ideal’ Dictionary of English Collocations
- Author
-
Nuccorini, Stefania, primary
- Published
- 2003
- Full Text
- View/download PDF
30. Predicting failure of hematopoietic stem cell mobilization before it starts: the Predicted Poor Mobilizer (pPM) score
- Author
-
Nicola Piccirillo, Paolo Corradini, Domenico Pastore, Roberta Nuccorini, Giorgina Specchia, Francesco Saraceni, Massimo Martino, Massimo Pini, Sarah Marktel, Andrea Mengarelli, Pietro Pioltelli, Giuseppe Milone, Francesco Zallio, Monica Poiani, Elvira Di Nardo, Saveria Capria, Sara Pasquina Pascale, Tiziana Moscato, Gianluca Gaidano, Immacolata Attolico, Pellegrino Musto, Paolo Perseghin, Francesco Merli, Lucia Farina, Luca Nassi, Martina Chiarucci, Simona Sica, Giuseppe Mele, Jacopo Olivieri, Francesco Lanza, Attilio Olivieri, Fabio Ciceri, Katia Codeluppi, Olivieri, Jacopo, Attolico, Immacolata, Nuccorini, Roberta, Pascale, Sara Pasquina, Chiarucci, Martina, Poiani, Monica, Corradini, Paolo, Farina, Lucia, Gaidano, Gianluca, Nassi, Luca, Sica, Simona, Piccirillo, Nicola, Pioltelli, Pietro Enrico, Martino, Massimo, Moscato, Tiziana, Pini, Massimo, Zallio, Francesco, Ciceri, Fabio, Marktel, Sarah, Mengarelli, Andrea, Musto, Pellegrino, Capria, Saveria, Merli, Francesco, Codeluppi, Katia, Mele, Giuseppe, Lanza, Francesco, Specchia, Giorgina, Pastore, Domenico, Milone, Giuseppe, Saraceni, Francesco, Di Nardo, Elvira, Perseghin, Paolo, and Olivieri, Attilio
- Subjects
Oncology ,Adult ,Male ,medicine.medical_specialty ,Multivariate analysis ,Adolescent ,lymphoma ,Filgrastim ,Likelihood ratios in diagnostic testing ,NO ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Predictive Value of Tests ,Risk Factors ,Internal medicine ,medicine ,Humans ,Child ,Hematopoietic Stem Cell Mobilization ,Aged ,Retrospective Studies ,Transplantation ,Mobilization ,Receiver operating characteristic ,business.industry ,Plerixafor ,Patient Selection ,Area under the curve ,poor mobiliser ,Hematology ,Middle Aged ,stem cell mobilization, lymphoma, myeloma, poor mobiliser, oredicting clinical score ,stem cell mobilization ,Settore MED/15 - MALATTIE DEL SANGUE ,myeloma ,oredicting clinical score ,030220 oncology & carcinogenesis ,Area Under Curve ,Child, Preschool ,Female ,business ,Multiple Myeloma ,030215 immunology ,medicine.drug - Abstract
Predicting mobilization failure before it starts may enable patient-tailored strategies. Although consensus criteria for predicted PM (pPM) are available, their predictive performance has never been measured on real data. We retrospectively collected and analyzed 1318 mobilization procedures performed for MM and lymphoma patients in the plerixafor era. In our sample, 180/1318 (13.7%) were PM. The score resulting from published pPM criteria had sufficient performance for predicting PM, as measured by AUC (0.67, 95%CI: 0.63â0.72). We developed a new prediction model from multivariate analysis whose score (pPM-score) resulted in better AUC (0.80, 95%CI: 0.76â0.84, p < 0001). pPM-score included as risk factors: increasing age, diagnosis of NHL, positive bone marrow biopsy or cytopenias before mobilization, previous mobilization failure, priming strategy with G-CSF alone, or without upfront plerixafor. A simplified version of pPM-score was categorized using a cut-off to maximize positive likelihood ratio (15.7, 95%CI: 9.9â24.8); specificity was 98% (95%CI: 97â98.7%), sensitivity 31.7% (95%CI: 24.9â39%); positive predictive value in our sample was 71.3% (95%CI: 60â80.8%). Simplified pPM-score can ârule inâ patients at very high risk for PM before starting mobilization, allowing changes in clinical management, such as choice of alternative priming strategies, to avoid highly likely mobilization failure.
- Published
- 2018
31. Martina Nied Curcio / Stefania Nuccorini / Paolo Vaciago, „Alle Wege führen nach Rom…“: Der Europäische Master für Lexikographie (EMLex) zu Gast an der Università degli Studi Roma Tre
- Author
-
Curcio, Martina Nied, primary, Nuccorini, Stefania, additional, and Vaciago, Paolo, additional
- Published
- 2019
- Full Text
- View/download PDF
32. 'Collocations in English-Italian Bilingual Dictionaries', in De Giovanni, C. (ed.), Fraseologia e paremiologia: passato, presente, futuro. Milano: Franco Angeli, 124-136, ISBN: 978-88-917-5286-4
- Author
-
NUCCORINI, Stefania, De Giovanni Centelles Cosimo, and Nuccorini, Stefania
- Subjects
collocations, bilingual dictionaries, English, Italian - Published
- 2017
33. English dictionary criticism in two lexicographical specialist journals
- Author
-
Stefania Nuccorini, Bielinska M., Schierholz S., and Nuccorini, Stefania
- Subjects
dictionary criticism, reviewer, specialist, review, dictionary types, sociocultural factors - Abstract
This article analyses different typologies of dictionary criticism, with special reference to reviews of British and American English dictionaries published in Dictionaries and in the International Journal of Lexicography between 1995 and 2015. The main aims are to assess reviewers’ roles and to see if (selected) reviews achieve their two basic communicative goals: to offer information about the dictionary reviewed and advice as to how appropriate it is to the intended/potential users’ needs, and to provide lexicographers with guidelines on how to improve their works. Research questions focus on whether reviewed dictionaries are described, analysed, and recommended (or otherwise) to the reader, and on whether reviews are based on a serious examination and judgment of the reviewed dictionary. Results point to the impartiality and trustworthiness of reviews written by specialists: other types of dictionary criticism unveil social, cultural and ideological factors affecting the dictionary- making process as well as the final product.
- Published
- 2017
34. Introduzione. Fraseologia e paremiologia. Passato, presente e futuro
- Author
-
Franceschi, Temistocle, Tosi, Renzo, Trovato, Salvatore C., Med, Natalia, Blanco, Carmen Mellado, Kauffer, Maurice, Urzì, Francesco, García Page, Mario, Williams, Geoffrey, Cacia, Daniela, Frassi, Paolo, Murano, Michela, Rondinelli, Paolo, Cervini, Claudia, Gisbert, María Valero, Fajardo, Luisa A. Messina, Stracquadanio, Marina, Gil, José Enrique Gargallo, Colucciello, Mariarosaria, Bukies, Gudrun, Meloni, Ilaria, Ortu, Franca, Skuza, Sylwia, Saggiomo, Carmen, Zykova, Irina, Falcão, Cecília, Cardoso, Nazaré, Martins, Cláudia, Pérez, Ana Mansilla, Smith, Anja, Szerszunowicz, Joanna, Violet, Alice, Maso, Elena Dal, Giacoma, Luisa, Gruber, Teresa, Häußinger, Barbara, Autelli, Erica, Konecny, NUCCORINI, Stefania, AA.VV., Cosimo De Giovanni, Franceschi, Temistocle, Tosi, Renzo, Trovato, Salvatore C., Med, Natalia, Blanco, Carmen Mellado, Kauffer, Maurice, Urzì, Francesco, García Page, Mario, Williams, Geoffrey, Nuccorini, Stefania, Cacia, Daniela, Frassi, Paolo, Murano, Michela, Rondinelli, Paolo, Cervini, Claudia, Gisbert, María Valero, Fajardo, Luisa A. Messina, Stracquadanio, Marina, Gil, José Enrique Gargallo, Colucciello, Mariarosaria, Bukies, Gudrun, Meloni, Ilaria, Ortu, Franca, Skuza, Sylwia, Saggiomo, Carmen, Zykova, Irina, Falcão, Cecília, Cardoso, Nazaré, Martins, Cláudia, Pérez, Ana Mansilla, Smith, Anja, Szerszunowicz, Joanna, Violet, Alice, Maso, Elena Dal, Giacoma, Luisa, Gruber, Teresa, Häußinger, Barbara, Autelli, Erica, and Konecny
- Published
- 2017
35. Oral Sessions
- Author
-
Massimo Martino, Luca Nassi, Roberta Nuccorini, Saveria Capria, Nicola Piccirillo, Attilio Olivieri, Fabio Ciceri, S. P. Pascale, Immacolata Attolico, Martina Chiarucci, M. Pizzuti, Andrea Mengarelli, and E. Di Nardo
- Subjects
Oncology ,Transplantation ,medicine.medical_specialty ,Bone marrow transplantation ,business.industry ,Hematology ,medicine.disease ,Article ,Preliminary analysis ,Lymphoma ,Internal medicine ,medicine ,Identification (biology) ,business ,Multiple myeloma - Published
- 2014
- Full Text
- View/download PDF
36. The treatment of lexical collocations in English Collocations Dictionaries and Learners’ Dictionaries: a languaging perspective
- Author
-
NUCCORINI, Stefania, Campagna Sandra, Elana Ochse, Virginia Pulcini, Martin Solly, and Nuccorini, Stefania
- Subjects
collocation, languaging, learners' dictionaries, collocations dictionaries - Abstract
Mastering collocations is a marker of communicative competence. Knowing which words work together – and which do not, one might add – is necessary for (advanced) learners to express meaning in a fluent and natural way. To this end, collocations, as transparent, more or less fixed combinations of words, often represent a problematic issue for learners of a foreign language, especially because of the different linguistic ways languages carve and express knowledge and common experience. In the field of English as a foreign language the inclusion and treatment of collocations is one of the main characteristics of general-purpose Learners’ Dictionaries (LDs), especially of more recent, corpus-based editions. According to the Oxford Advanced Learner’s Dictionary (OALD, 2010, Foreword) “it's not enough to know the right vocabulary - students also have to know which words go together if they want to sound natural”, and according to the Macmillan English Dictionary for Advanced Learners (MED, on-line edition, Introduction) students need information not only about meaning but also about how words combine “to write natural-sounding English”. In a similar perspective and in a considerably more detailed way, specialised Collocations Dictionaries aim at helping learners of English express their ideas “naturally and convincingly” (Oxford Collocations Dictionary (OCD) 2009, back cover) and “write more natural and accurate English” (Macmillan Collocations Dictionary (MCD) 2010, back cover). This paper compares the treatment of some verb+noun collocations in the above-mentioned Dictionaries. The comparison aims at assessing their respective role in helping learners avoid collocational errors. It also envisages the possibility, to be further explored with the active involvement of learners, of connecting the role of collocations as a marker of communicative fluency with languaging, not only as the ability “to express in language, put into words; to tell, to describe, report” (OED, s.v. language verb), but also as “a dynamic, never-ending process of using language to make meaning” and “of shaping knowledge and experience through language” (Swain 2006: 96, 98). Swain further expounds on this concept in a metalinguistic direction concerning “languaging about language”, considered as “one of the ways we learn a second language to an advanced level” (2006: 96), and reports on a number of studies showing how “students were stimulated to language about language because in doing the tasks, they realised that there were things about the target language that they did not know, or were unsure of” (2006: 105). The four dictionaries are thus also analysed to see if while helping learners avoid errors they also engage them in a form of silent ‘languaging’ à la Swain1, in the sense of stimulating an interaction between what students wrongly write and what dictionaries correctly report, hopefully leading to a higher degree of awareness and to improved performance. Among the four dictionaries2 the OALD and the OCD on the one hand, and the MED and the MCD on the other, are supposed to share common sources (corpora) and similar policies regarding the definition of collocations, alongside differently tailored yet partially shared objectives. The analysis of selected entries has been based on verb+object noun collocational errors from ICLE-IT, the Italian component of the Louvain International Corpus of Learner English (Granger et al., 2009, Granger et al., 2002, Prat Zagrebelsky, 2004) as a source to identify learners’ needs. Learners’ verb+object noun productions are considered as collocational errors on the basis of the wrong choice of the verb for the object noun (Martelli 2007: 41). The semasiological approach of the two LDs and the onomasiological approach of the two collocations dictionaries (Coffey 2005) affect their respective macro- and micro-structure, and this partly explains the lexicographical and structural differences in their inclusion and treatment of the selected collocations. Yet, findings show that, alongside overlappings, the entries analysed also reveal differences, probably due to different descriptive approaches, different sources and different notions of use restrictions
- Published
- 2016
37. Phraseology and Lexicography. English and Italian Dictionaries of Collocations:1 a Comparison
- Author
-
NUCCORINI, Stefania, Elena Dal Maso , Carmen Navarro, and Nuccorini, Stefania
- Subjects
phraseology, lexicography, English Italian - Abstract
Collocations are a major part of phraselogy; independently of terminological aspects, they are a much debated linguistic, theoretical, and lexicographical issue in both English and Italian, because of their pervasiveness on the one hand, and their classification with regard to different types of phraseological units and free combinations on the other. Lexicographically, collocations are included in general dictionaries and in specialised works: crucial policies of definition, inclusion and treatment highlight moot points especially for didactic purposes. In this respect English and Italian monolingual dictionaries of collocations well represent the current development of the long-standing connections between phraseology and both general and specialised lexicography, in particular with reference to pedagogic purposes. The ultimate, long-term aim of the research project this paper is based on is to start laying the foundation for the making of a bilingual dictionary of Italian and English lexical collocations, which would take into consideration the relation between the traditionally normative role of dictionaries and the usage-based, often innovative nature of collocations. The aim of the present paper is to identify convergences and asymmetries in defining and classificatory issues and in inclusion and treatment policies in English and Italian dictionaries of collocations, to see to what extent there is common ground which would be relevant to the above mentioned lexicographical project
- Published
- 2016
38. Phraseology in Time: On the Innovative Treatment of Word Combinations in Specialised Nineteenth-Century Bilingual Dictionaries
- Author
-
Stefania Nuccorini and Nuccorini, Stefania
- Subjects
060201 languages & linguistics ,Linguistics and Language ,History ,language use ,media_common.quotation_subject ,05 social sciences ,Phraseology ,06 humanities and the arts ,050105 experimental psychology ,Language and Linguistics ,Linguistics ,Lexicography ,specialised bilingual lexicography ,0602 languages and literature ,0501 psychology and cognitive sciences ,Conversation ,nineteenth century ,prescriptivism ,media_common - Abstract
Historically, the word phraseology has been connected with lexicography (Knappe 2004), especially with bilingual dictionaries (Moon 2000) and their norm-setting role associated with foreign-language teaching and learning. Nineteenth-century specialised bilingual lexicography seems to depart from the then usual norm-based approaches and to favour the inclusion of use-related phraseological combinations. This paper analyses the treatment of word combinations which can be referred to as ante-litteram collocations in two rather different dictionaries, namely Tarver’s Royal Phraseological English–French, French–English Dictionary (1845–53) and Nutt’s English–Italian Conversation Dictionary (1894), to see to what extent nineteenth-century specialised bilingual lexicography has marked a move away from prescriptivism and affected later studies on the lexicographical treatment of collocation and changes in the use of the word phraseology.
- Published
- 2016
39. In search of ‘phraseologies’
- Author
-
Stefania Nuccorini and Nuccorini, Stefania
- Subjects
Linguistics and Language ,Literature and Literary Theory ,Language and Linguistics ,Linguistics ,Phraseology ,English-Italian contrastive analysi ,phraseological pattern ,Situated ,Cognate ,Sociology ,corpus data ,Contrastive linguistics ,Contrastive analysis ,Meaning (linguistics) - Abstract
This article is situated at the crossroads between contrastive linguistics and phraseology. Its objective is to show how some characteristic elements of the co-text of supposedly true friends in English and Italian form different phraseological patterns which account for (un)suspected semantic and pragmatic divergences in their use. Some pairs of true friends, which are supposed to share the same meaning and use in the two languages, have been analysed in two broadly comparable corpora. Findings shed new light on the web of linguistic, cultural and pragmatic relations occurring beneath the lexical level: they ultimately explain why the cognate words analysed often turn out not to be translational equivalents of each other. The same corpus-based approach could prove helpful in analysing similar phenomena in other pairs of languages.
- Published
- 2006
- Full Text
- View/download PDF
40. Predicting failure of hematopoietic stem cell mobilization before it starts: The predicted poor mobilizer (pPM) score
- Author
-
Olivieri, J., Attolico, I., Nuccorini, R., Pascale, S. P., Chiarucci, M., Poiani, M., Corradini, P., Farina, L., Gaidano, G., Nassi, L., Sica, S., Piccirillo, N., Pioltelli, P. E., Martino, M., Moscato, T., Pini, M., Zallio, F., Ciceri, F., Marktel, S., Mengarelli, A., Musto, P., Capria, S., Merli, F., Codeluppi, K., Mele, G., Lanza, F., Specchia, G., Pastore, D., Milone, G., Saraceni, F., Di Nardo, E., Perseghin, P., Olivieri, A., Sica S. (ORCID:0000-0003-2426-3465), Piccirillo N. (ORCID:0000-0002-1688-1987), Olivieri, J., Attolico, I., Nuccorini, R., Pascale, S. P., Chiarucci, M., Poiani, M., Corradini, P., Farina, L., Gaidano, G., Nassi, L., Sica, S., Piccirillo, N., Pioltelli, P. E., Martino, M., Moscato, T., Pini, M., Zallio, F., Ciceri, F., Marktel, S., Mengarelli, A., Musto, P., Capria, S., Merli, F., Codeluppi, K., Mele, G., Lanza, F., Specchia, G., Pastore, D., Milone, G., Saraceni, F., Di Nardo, E., Perseghin, P., Olivieri, A., Sica S. (ORCID:0000-0003-2426-3465), and Piccirillo N. (ORCID:0000-0002-1688-1987)
- Abstract
Predicting mobilization failure before it starts may enable patient-tailored strategies. Although consensus criteria for predicted PM (pPM) are available, their predictive performance has never been measured on real data. We retrospectively collected and analyzed 1318 mobilization procedures performed for MM and lymphoma patients in the plerixafor era. In our sample, 180/1318 (13.7%) were PM. The score resulting from published pPM criteria had sufficient performance for predicting PM, as measured by AUC (0.67, 95%CI: 0.63-0.72). We developed a new prediction model from multivariate analysis whose score (pPM-score) resulted in better AUC (0.80, 95%CI: 0.76-0.84, p < 0001). pPM-score included as risk factors: increasing age, diagnosis of NHL, positive bone marrow biopsy or cytopenias before mobilization, previous mobilization failure, priming strategy with G-CSF alone, or without upfront plerixafor. A simplified version of pPM-score was categorized using a cut-off to maximize positive likelihood ratio (15.7, 95%CI: 9.9-24.8); specificity was 98% (95%CI: 97-98.7%), sensitivity 31.7% (95%CI: 24.9-39%); positive predictive value in our sample was 71.3% (95%CI: 60-80.8%). Simplified pPM-score can "rule in" patients at very high risk for PM before starting mobilization, allowing changes in clinical management, such as choice of alternative priming strategies, to avoid highly likely mobilization failure.
- Published
- 2018
41. Plerixafor Added to Chemotherapy Plus G-CSF Is Safe and Allows Adequate PBSC Collection in Predicted Poor Mobilizer Patients with Multiple Myeloma or Lymphoma
- Author
-
Sara Pasquina Pascale, Massimo Martino, Giuseppe Milone, Maurizio Musso, Roberta Nuccorini, Pasquale Iacopino, Bernardo Rossini, Patrizia Tedeschi, Vincenzo Pavone, Elvira Di Nardo, Alessandra Crescimanno, Immacolata Attolico, Angelo Ostuni, Sabrina Coluzzi, and Attilio Olivieri
- Subjects
Adult ,Male ,Oncology ,Benzylamines ,medicine.medical_specialty ,PBSC mobilization ,Lymphoma ,Anti-HIV Agents ,medicine.medical_treatment ,Antigens, CD34 ,Autologous stem cell transplantation ,Poor mobilizers ,Cyclams ,Transplantation, Autologous ,Autologous stem-cell transplantation ,Heterocyclic Compounds ,Internal medicine ,Granulocyte Colony-Stimulating Factor ,Humans ,Medicine ,Hematopoietic Stem Cell Mobilization ,Multiple myeloma ,Aged ,Peripheral Blood Stem Cell Transplantation ,Transplantation ,Chemotherapy ,business.industry ,Plerixafor ,Recovery of Function ,Hematology ,Middle Aged ,Hematopoietic Stem Cells ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Female ,Bone marrow ,Multiple Myeloma ,business ,medicine.drug - Abstract
We evaluated the safety and efficacy of plerixafor, subsequent to disease-specific chemotherapy followed by granulocyte-colony stimulating factor (G-CSF), in 37 multiple myeloma (MM) or lymphoma patients, who were candidates for autologous stem cell transplantation (ASCT) predicted as poor mobilizers (PMs). Patients were identified as predicted PMs according to the history of a previously failed mobilization attempt or the presence of ≥1 factors predicting an unsuccessful harvest, such as advanced disease, prior extensive radiotherapy, or prolonged treatment, with stem cell poisons, advanced age, or extensive bone marrow involvement. Plerixafor (0.24 mg/kg) was administered subcutaneously for up to 3 consecutive days while continuing G-CSF for 9 to 11 hours before the planned apheresis. Plerixafor administration was safe and no significant adverse events were recorded. We observed a median 4-fold increase (range: 1.4-32) in the number of circulating CD34(+) cells following plerixafor compared with baseline CD34(+) cell concentration (from a median of 5 cells/μL, range: 1-32, to a median of 32 cells/μL, range: 6-201). Twenty-seven of the 37 patients (14 of 17 with MM and 13 of 20 with lymphoma) had ≥2×10(6) CD34(+) cells/kg collected in 1-3 apheretic procedures. Of the 27 patients rescued with plerixafor, 24 (13 MM, 11 lymphoma) have been transplanted with plerixafor-mobilized peripheral blood stem cells, showing a rapid and durable hematologic recovery. Our results suggest that the addition of plerixafor to G-CSF after disease-oriented chemotherapy is safe and allows for a satisfactory harvest in order to perform a safe ASCT, in a relevant proportion of lymphoma and MM patients considered to be PMs.
- Published
- 2012
- Full Text
- View/download PDF
42. On gifts and presents
- Author
-
NUCCORINI, Stefania, Ambrosini Richard McCourt John Terrinoni Enrico Zanotti Serenella, and Nuccorini, Stefania
- Subjects
communication ,wordplay ,semantic relation - Abstract
This paper elaborates on the use of the nouns gift and present, and on the linguistic relationships linking them. It also expounds on the morphological and semantic relationships involving the noun present, the adjective present, and the homographic, but not homophonic verb present. The collocational profiles of the nouns gift and present, with reference to the different meanings of the latter, are also considered to identify the connotative aspects of their use and their sematic prosodies. The analysis is carried out on the basis of data from the Oxford English Dictionary (OED, on-line) and from the WordBanks on-line English corpus (WB). These two totally different sources are used to identify the (etymological) linguistic features behind the creative wordplay which involves the words gift and present, as used in an advertisement, to compare their uses and to highlight how the exploitation of linguistic relationships makes manipulations possible and ultimately determines effective communication.
- Published
- 2014
43. Norm and use/usage: dichotomy, convergence or overlapping?
- Author
-
NUCCORINI, Stefania, Molino Alessandra Zanotti Serenella, and Nuccorini, Stefania
- Subjects
media ,dictionarie ,norm/usage - Abstract
The article surveys the concepts of 'norm' and 'usage' or 'use' from the lexicological and lexicographical perspective, with special reference to the English tradition. It also deals with major findings concerning the use of lexis in the media, with reference to the articles published in the same volume, which it also prefaces, in as far as it accounts for the aims of the national research project bearing the same title and for their achievement.
- Published
- 2014
44. POST INDUCTION WT1 VALUES AND WT1 ONSET/POST INDUCTION RATIO ARE USEFULL TO STRATIFY ACUTE MYELOID LEUKEMIA PATIENTS
- Author
-
Coluzzi, S., Introcaso, T, Iallorenzi, P., Di Nardo, E., Pascale, S. P., Nuccorini, R., Attolico, I., Matturro, A., Amendola, A., Cimminiello, M., Vertone, D., Filardi, N., and Pizzuti, M.
- Published
- 2016
45. Expression of some ATP-binding cassette transporters in acute myeloid leukemia
- Author
-
Salvia, Antonella Maria, primary, Cuviello, Flavia, additional, Coluzzi, Sabrina, additional, Nuccorini, Roberta, additional, Attolico, Immacolata, additional, Pascale, Sara Pasquina, additional, Bisaccia, Faustino, additional, Pizzuti, Michele, additional, and Ostuni, Angela, additional
- Published
- 2017
- Full Text
- View/download PDF
46. Usage, Authority and Stance in the Lexicographic Management of English: Webster's 3rd, OED, Learner's Dictionaries.
- Author
-
Nuccorini, Stefania
- Subjects
DEFINITIONS ,AUTHORITY ,ENGLISH language ,LEXICOGRAPHY - Abstract
This paper deals with the concepts of usage, authority and stance in the field of lexicography, with special reference to the first edition of Webster's Third New International Dictionary of the English Language (W3), the Oxford English Dictionary (OED), and different editions of learner's dictionaries up to the latest ones. The main aim is to compare and assess different dictionary-making policies and their outcomes on the basis of the more or less overt role played by the interpretations and implementations of the above-mentioned concepts of usage, authority and stance and their interconnections with descriptivism and prescriptivism. Scholarly approaches to the concepts of usage, authority, and stance are presented in section 1 to outline the scientific background to their pervasiveness in dictionary-making policies. The definitions of the words usage, authority and stance given in W3 and in the OED, whose outstanding positions in the lexicographical field are undisputed, are then analysed in section 2. The related definitions of descriptivism and prescriptivism are compared and their application and instantiation are exemplified by the treatment of woman question (as a lexical item) in the OED, as representative of its historical perspective, and of ain't in W3, as the symbol of its lexicographic breakthrough (section 3). Section 4 focuses on Learner's Dictionaries and their specific pedagogical role with reference to usage, authority and stance, and on their definitions of ain't in different editions, to see if that headword has undergone socio-cultural changes in time. A few concluding remarks are offered in section 5. [ABSTRACT FROM AUTHOR]
- Published
- 2020
47. English Lexicography in Time: Social and Cultural Issues. An Introduction.
- Author
-
Béjoint, Henri and Nuccorini, Stefania
- Subjects
LEXICOGRAPHY ,ALCOHOL drinking - Abstract
An introduction is presented in which discusses several articles in the issue on topics including lexicographical descriptivism; acquisition of English terminology in the medical field; and linguistic traces of African languages in Caribbean English.
- Published
- 2020
48. Long-term outcome and prospective validation of NIH response criteria in 39 patients receiving imatinib for steroid-refractory chronic GVHD
- Author
-
Paola Bresciani, Francesco Onida, Roberta Nuccorini, Jacopo Olivieri, Enzo Pavone, Nicola Mordini, Pietro Leoni, Andrea Bacigalupo, Francesca Patriarca, Antonella Poloni, Michele Cimminiello, Roberta Fedele, Sabrina Coluzzi, Sara Pasquina Pascale, Fabrizio Pane, Paolo Corradini, Silvia Svegliati, Attilio Olivieri, Armando Gabrielli, Carmine Selleri, Olivieri, A, Cimminiello, M, Corradini, P, Mordini, N, Fedele, R, Selleri, C, Onida, F, Patriarca, F, Pavone, E, Svegliati, S, Gabrielli, A, Bresciani, P, Nuccorini, R, Pascale, S, Coluzzi, S, Pane, Fabrizio, Poloni, A, Olivieri, J, Leoni, P, and Bacigalupo, A.
- Subjects
Male ,Time Factors ,medicine.medical_treatment ,Graft vs Host Disease ,Hematopoietic stem cell transplantation ,Biochemistry ,Gastroenterology ,Severity of Illness Index ,Piperazines ,Receptors ,Receptors, Platelet-Derived Growth Factor ,Prospective Studies ,Prospective cohort study ,Platelet-Derived Growth Factor ,Hematopoietic Stem Cell Transplantation ,Hematology ,Middle Aged ,Survival Rate ,Benzamides ,Prednisolone ,Imatinib Mesylate ,Female ,medicine.drug ,Adult ,medicine.medical_specialty ,Monitoring ,Antineoplastic Agents, Hormonal ,Immunology ,Antineoplastic Agents ,Disease-Free Survival ,Internal medicine ,Severity of illness ,medicine ,Aged ,Autoantibodies ,Chronic Disease ,Follow-Up Studies ,Humans ,Lymphoproliferative Disorders ,Monitoring, Physiologic ,Myeloproliferative Disorders ,Protein Kinase Inhibitors ,Pyrimidines ,Physiologic ,Survival rate ,Hormonal ,business.industry ,Imatinib ,Cell Biology ,Surgery ,Clinical trial ,Settore MED/15 - MALATTIE DEL SANGUE ,Imatinib mesylate ,business - Abstract
Forty adults aged 28 to 73 years were entered into a prospective trial of imatinib for the treatment of steroid-refractory chronic graft-versus-host disease (SR-cGVHD). After 6 months, intention-to-treat (ITT) analysis of 39 patients who received the drug, regardless of the duration of treatment, revealed 14 partial responses (PR), 4 minor responses (MR) with relevant steroid sparing (46%) according to Couriel criteria, and 20 ≥ PR (51.3%), as per the National Institutes of Health (NIH) criteria and NIH severity score changes. The best responses were seen in the lungs, gut, and skin (35%, 50%, and 32%, respectively). After a median follow-up of 40 months, 28 patients were alive, with a 3-year overall survival (OS) and event-free survival of 72% and 46%, respectively. The 3-year OS was 94% for patients responding at 6 months and 58% for nonresponders according to NIH response, suggesting that these criteria represent a reliable tool for predicting OS after second-line treatment. Monitoring of anti-platelet-derived growth factor receptor (PDGF-R) antibodies showed a significant decrease in PDGF-R stimulatory activity in 7 responders, whereas it remained high in 4 nonresponders. This study confirms the efficacy of imatinib against SR-cGVHD and suggests that the response at 6 months significantly predicts long-term survival.
- Published
- 2013
49. Italian EFL learners’ collocational errors and English collocations dictionaries: a case study
- Author
-
NUCCORINI, Stefania and Nuccorini, Stefania
- Subjects
word combinations ,collocations dictionarie ,collocational error - Abstract
The paper discusses selected erroneous and questionable verb+noun, noun+verb and adjective+noun combinations taken from the Italian component of the International Corpus of Learner English (ICLE-IT) (Granger et al., 2002; Granger et al., 2009; Prat Zagrebelsky, 2004), and analyses the treatment of the words they are composed of in The BBI Combinatory Dictionary of English (3rd edn., 2009) (BBI), The Oxford Collocations Dictionary for Students of English (2nd edn., 2009) (OCD), and the Macmillan Collocations Dictionary for learners of English (2010) (MCD). To assess their acceptability, learners’ productions are compared with data from the English corpus WordBanks Online and with what is recorded in the BBI, the OCD, and the MCD. The aim is to assess the assistance of these dictionaries in helping learners avoid collocational errors. Given the small number of the combinations analysed, findings cannot be generalised: however, they show that use restrictions are often not signalled in the three dictionaries and that the base-collocate relation should be revised, especially in the case of verb+noun and noun+verb combinations, so as to include both subject and object nouns in verb entries
- Published
- 2013
50. Introduction
- Author
-
NUCCORINI, Stefania, Nuccorini S, and Nuccorini, Stefania
- Subjects
data ,phraseology ,description - Published
- 2002
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.