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In the article, the author presents a theoretical analysis of the social functions of self-employment in modern Russia during a pandemic, sanctions, and isolation based on a sociological study. The public sector, which has dominated Russia for a little less than a century, has practically given way to the private sector, forcing a new attitude to many facts, such as self-employment. The shadow market of the self-employed turns out for Russia, first of all, in huge, incomparable budget losses. The shadow labour market of self-employed citizens makes representatives of small and medium-sized businesses engaged in similar activities uncompetitive. Self-employment and this is a fact, is inextricably linked with corruption. At the same time, it should be noted that self-employment also performs positive social functions. First of all, self-employment regulates the labour market, does not allow unemployment to grow, and contributes to the survival of a large stratum of our citizens who, for various reasons, due to various life circumstances, found themselves below the poverty line. For several years now, thanks to self-employment in our society, the gap between the poor and the super-rich has been narrowing. Self-employment has played a significant role and will certainly continue to play in the context of the pandemic. The historic events of February 24 this year, related to the special operation in Ukraine, showed that thanks to the efforts of the leader of our country, the Russian army has already gained the ability to ensure the security of our Motherland for many years to come. And this is very important. Tough sanctions, an attempt at an economic blockade, and isolation of our state will allow us to create a model of a new economy based on our strengths. Now the key task for Vladimir Putin is precisely the solution to the issue of economic independence. Self-employment should again play a positive role in the abundance of sanctions and isolation, when tens of thousands, hundreds of thousands, and possibly millions of our fellow citizens have lost and continue to lose their means of subsistence in an instant.

The article provides a theoretical analysis of the launch of a prospective investment cycle “Greater Siberia” in the Russian Federation. The study is based primarily on the growing debate in addressing the issue of creating new scientific, industrial, and economic centers in Siberia, which should serve new cities with a population of 300 thousand to one million inhabitants. In other words, these are distinctive clusters with developed infrastructure, research centers, and breakthrough technologies, not only in the extractive industries but primarily in the processing industries.

The chapter presents a new approach to determining the strength of masonry reinforced with transverse meshes in mortar joints. The method consists of using the values of the modulus of elasticity and limiting deformations of the stone material, mortar for joints, and both steel and composite reinforcements. An analytical notation is proposed that integrally takes into account the characteristics of the initial materials. The results of physical tests of centrally loaded masonry pillars reinforced with steel and composite meshes are given. To test the masonry, widely used materials were used: solid brick and cement-sand mortar. The values of the bearing capacity, deformations, and internal stresses of the masonry are obtained. It is determined that the stresses in the reinforcing bars of the meshes are unevenly distributed in the horizontal plane of the mortar joint and amount to 20–37% of the design resistance of the mesh material. The strength of masonry reinforced with composite meshes is 65–75% of steel of the same cross section. It is shown that there is a good convergence of test results with the presented analytical dependence.

In the article, the authors present a method of constrained bending of aircraft sheet parts with curved sides by an elastic medium. The process of conducting constrained bending is described. A schematic description of the process is presented. The manufacture of a part is carried out in two steps. As a result of the first step, a piece is obtained with thinning in the radius part, the second step is accomplished with a unit die of reduced height. The resulting wave of excess material is deformed along the radius of the bending mandrel. In the finished part, an increase in the thickness of the workpiece is observed in the zone of the bending radius. The wave of excess material is formed due to a special allowance, the size of which is the critical factor for achieving this increase in thickness. The analytical model for determining the allowance is based on generally accepted assumptions and principles for calculating process parameters. To determine the allowance, an approximation of the shape of the excess wave by a tangential function is proposed. This allows you to get an analytical dependence that relates the geometry of the part and the thickening of the wall to the size of the allowance. The size of the allowance is limited to a certain range, the lower boundary of which is determined by the onset of plastic deformations, the upper one - by the possibility of loss of stability, leading to irreparable spoilage. The results are illustrated by graphs of the dependence of the minimum and maximum allowance for the side height on the ratios of the workpiece wall thickness, the radius of the side bending and the radius of the side in plan. Characteristic curves and analytical dependencies are presented in a dimensionless form, where the geometric parameters are assigned to the radius of the bending tool, that is, to the radius of bending of the part side on the inner surface.

An elevated white blood cell (WBC) count is associated with an increased risk of ischemic events among acute coronary syndrome (ACS) patients, but the association between WBC count and bleeding in ACS patients is not well established. The aim of this analysis was to assess and compare the association between WBC count and the occurrence of short- and long-term bleeding and ischemic events. This was a post hoc analysis of the ATLAS ACS2-TIMI 51 trial. A subset of patients had a WBC count measurement at baseline (n = 14,231, 91.6%). Univariate and multivariable Cox proportional hazard models were constructed to determine if there is an association between WBC count at baseline and a composite outcome of Thrombolysis in Myocardial Infarction (TIMI) major and minor bleeds at 30 days and 1 year. Variables with a p0.2 in the univariate analysis were included as potential parameters in the backward selection process A similar multivariable model was constructed to assess the association between WBC count and a composite ischemic endpoint of cardiovascular death, myocardial infarction and stroke. An increased risk of bleeding per a 1 × 10

Рассмотрены вопросы застройки городов, создания новых конструкций и материалов, совершенствования методов расчета несущих конструкций и их усиления, мониторинга зданий, внедрения новых строительных технологий и экономической оценки строительства. Для научных работников, строителей, аспирантов, магистрантов и студентов. Материалы конференции воспроизведены с авторских оригиналов рукописей, представленных в оргкомитет.

D-dimer has been used as both a diagnostic and prognostic biomarker in the assessment of patients with venous thromboembolism, but its prognostic value in the setting of arterial acute coronary syndromes (ACS) and the ability of pharmacotherapy to reduce D-dimer in ACS is less well characterized. It was hypothesized that elevated baseline D-dimer would be associated with poor clinical outcomes in ACS, and that Factor Xa inhibition with Rivaroxaban would reduce D-dimer acutely and chronically. The ATLAS ACS TIMI-46 trial assessed the safety and efficacy of rivaroxaban compared with placebo in ACS patients. A subset of subjects had a D-dimer measured at baseline (n = 1,834, 52.5%). A univariate and multivariable logistic regression assessed the relation between baseline D-dimer and a composite end point of cardiovascular death, myocardial infarction, or stroke through 6 months. The Wilcoxon rank sum test was used to compare change in D-dimer level between the treatment groups from baseline. Baseline D-dimer was associated with the composite efficacy outcome in a univariate logistic regression (odds ratio 1.15, 95% confidence interval 1.03 to 1.29, p = 0.015) and a multivariable logistic regression (odds ratio 1.13, 95% confidence interval 1.00 to 1.28, p = 0.048). Rivaroxaban administration lowered D-dimer levels compared wth placebo after administration of the first dose of study drug (p = 0.026), at day 30 (p < 0.001) and day 180 (p < 0.001). In conclusion, elevated baseline D-dimer was associated with an increased risk of the composite outcome within 6 months of the ACS event and administration of the Factor Xa inhibitor rivaroxaban was associated with lower D-dimer levels compared with placebo after the first dose, at day 30 and day 180.

The modeling of the "reservoir with oil – system "GET" – soil massif" system for 1392 random trajectories of air temperature, wind speed and snow cover thickness changes for two years is carried out. It is shown that the result temperature distribution in the soil massif has the form of normal distribution.

The conditions for the quantitative determination of codeine phosphate in the culture fluid of Rhodococcus by reversed-phase high-performance liquid chromatography (RP-HPLC) are established. The specificity, linearity, precision, and accuracy of the method are confirmed by the validation procedure.

The paper shows that high temperature heating (from 1 100 to 1 170 0C) for the subsequent quenching of high-chromium steels of a martensitic-carbide class 95X18 and X12MFL provides structure to the metal base, which consist of high-carbon containing martensite and residual metastable austenite with some carbides. The resulting structure has a high capacity for frictional hardening. Experiments with cold processing treatment of the analyzed steels also showed that after high-temperature quenching with subsequent cooling to -70 0C, sufficient cooling martensite is formed, which in combination with residual metastable austenite, provides an increase of abrasive wear resistance by 25 % compared to high temperature annealing.

The model of passage of vessels through a section of the waterway is considered, which independently determines the order of passage of vessels with limited capacity of sections of the track. Such a model will consist of a number of standard algorithmic networks. When composing the schedule in the model, the following preference rules were used: first-come-first-served (that is, if the ship occupied the workplace, this decision is not canceled); The rule of the shortest operation; For the swamps the priority of vessels going downstream (the direction of flow from the source to the drain). An algorithmic network that implements the search for an acceptable schedule must implement the following for conflicting operations: the operation that has started is not interrupted; If several operations simultaneously claim for one workplace (port, reach) and their number is greater than its throughput, then the conflict resolution is carried out in accordance with predefined preference rules or based on the user's decision; If the operation is waiting for the release of the workplace, it does not occupy the resource; The resource is returned immediately after the operation is completed. The considered design of algorithmic networks allows to resolve the conflict, with a simultaneous resource request, to take the resource once, remember that it was received and return it after the end of the operation, then the resource receives a contra-controlling operation for execution. However, the use of this design introduces redundancy into the model, even if it is used only for conflicting operations. The model is presented in the language of algorithmic networks and is implemented in the system of modeling automation KOGNITRON.

T-helper 17 (Th17) cells have important functions in adaptor immunity and have also been implicated in inflammatory disorders. The bromodomain and extraterminal domain (BET) family proteins regulate gene transcription during lineage-specific differentiation of naive CD4+ T cells to produce mature T-helper cells. Inhibition of acetyl-lysine binding of the BET proteins by pan-BET bromodomain (BrD) inhibitors, such as JQ1, broadly affects differentiation of Th17, Th1, and Th2 cells that have distinct immune functions, thus limiting their therapeutic potential. Whether these BET proteins represent viable new epigenetic drug targets for inflammatory disorders has remained an unanswered question. In this study, we report that selective inhibition of the first bromodomain of BET proteins with our newly designed small molecule MS402 inhibits primarily Th17 cell differentiation with a little or almost no effect on Th1 or Th2 and Treg cells. MS402 preferentially renders Brd4 binding to Th17 signature gene loci over those of housekeeping genes and reduces Brd4 recruitment of p-TEFb to phosphorylate and activate RNA polymerase II for transcription elongation. We further show that MS402 prevents and ameliorates T-cell transfer-induced colitis in mice by blocking Th17 cell overdevelopment. Thus, selective pharmacological modulation of individual bromodomains likely represents a strategy for treatment of inflammatory bowel diseases.

The temperature fields beneath a tank with oil in the Vankor oil field are calculated. Stefan's problem is solved taking account of random variations in the meteorological characteristics is solved. A method of computing the probability of finding soil in nonfrozen or frozen states at an arbitrary point of the design region is developed.

[Image: see text] Covalent probes can display unmatched potency, selectivity, and duration of action; however, their discovery is challenging. In principle, fragments that can irreversibly bind their target can overcome the low affinity that limits reversible fragment screening, but such electrophilic fragments were considered nonselective and were rarely screened. We hypothesized that mild electrophiles might overcome the selectivity challenge and constructed a library of 993 mildly electrophilic fragments. We characterized this library by a new high-throughput thiol-reactivity assay and screened them against 10 cysteine-containing proteins. Highly reactive and promiscuous fragments were rare and could be easily eliminated. In contrast, we found hits for most targets. Combining our approach with high-throughput crystallography allowed rapid progression to potent and selective probes for two enzymes, the deubiquitinase OTUB2 and the pyrophosphatase NUDT7. No inhibitors were previously known for either. This study highlights the potential of electrophile-fragment screening as a practical and efficient tool for covalent-ligand discovery.

Background A residual risk of ischemic events following an acute coronary syndrome (ACS) remains despite antiplatelet therapy. The addition of an antithrombin as part of a “dual pathway” approach may further improve outcomes as thrombin generation persists for several months post‐ACS. The present study evaluates the safety and efficacy of “dual pathway” therapy (rivaroxaban plus aspirin) as compared with aspirin monotherapy among post‐ACS patients. Methods and Results A total of 1477 patients were analyzed in a pooled analysis of subsets of the ATLAS ACS‐TIMI (Anti‐Xa Therapy to Lower cardiovascular events in addition to Aspirin with or without thienopyridine therapy in Subjects with Acute Coronary Syndrome – Thrombolysis in Myocardial Infarction) 46 and ATLAS ACS 2‐TIMI 51 trials including post‐ACS patients receiving aspirin monotherapy and randomized to either rivaroxaban 2.5 mg BID or rivaroxaban 5 mg BID or placebo. The primary efficacy end point was a composite of cardiovascular death, myocardial infarction (MI), or stroke (ischemic, hemorrhagic, or of uncertain cause). The primary safety end point was TIMI‐non‐coronary artery bypass (CABG) major bleeding. The combined rivaroxaban group (2.5 or 5 mg BID) among stabilized post‐ACS patients on a background of aspirin monotherapy was associated with a significant reduction in the primary end point as compared with placebo (hazard ratio=0.65, 95% CI=0.45–0.92, P=0.016). Although the combined rivaroxaban dose groups were associated with higher rates of non‐CABG TIMI major bleeding, the 2.5 mg dose group was not, and the overall number of patients experiencing a non‐CABG TIMI major bleeding event was low (1.5%). Conclusions Among patients in the immediate post‐ACS period, a “dual pathway” approach using aspirin and low‐dose rivaroxaban may reduce the risk of secondary atherothrombotic events, but increase bleeding risk. Clinical Trial Registration URL: https://www.clinicaltrials.gov. Unique identifiers: NCT00402597; NCT00809965., See Editorial by Harrison and Newby

Analysis of thermal stresses in tubes and a compensator, taking into account water heating in each heater bunch and temperature at which its mounting is implemented, and of stresses on pressure is presented. The 3D-model of the horizontal delivery water heater of PSG-4900-0.3-1.14 type is used. The tube plate is represented as the 3D-body with 6863 holes with offset center of the perforated area, the steam space shell is represented as a cylindrical casing, the bottoms of water chambers are considered as elliptical casings, the four-lens compensator is represented in the form of toroidal casings, and the tubes are considered as beams operating in tensile-compression and bending in two planes. Calculations were carried out for different temperatures of superheated steam and a steam space shell, respectively, as well as designs with compensator and without it. Various temperature values of the tubes on the passes were calculated and set. The studies were carried out taking into account nonaxis-symmetrical spacing the tube plate and compensator deformation. The calculation results of tensile-compression stresses in the tubes are presented. Furthermore, the central tubes experience compressive stresses, whose maximal values take place on the border between the tubes of the fourth and of the first passes. For its decrease, it is recommended to increase the distance between the tubes of these passes. The tension stresses in the peripheral tubes are the maximal stresses. To reduce the stresses and, therefore, increase service life of the delivery water heater at using wet or superheated (not more than by 30–50°C) steam in it (the larger value refers to the brass tubes and the water pressure of 1.6–2.5 MPa), it is necessary to recommend the noncompensatory design at using the steam superheated by more than 30–50°C (at Ural Turbine Works, it is the turbines of T-250/300-23.5 and T-113/145-12.4 types with intermediate superheating) and to recommend the installation of the compensator operating only at compression.

The effect of the temperature of heating for quenching on the content of retained austenite and its resistance to the deformation-induced martensitic transformation, the hardening capacity, and the resistance to abrasive wear are studied for high-carbon tool steels 150KhNML and Kh12MFL of pearlitic and ledeburitic classes.

Covalent probes can display unmatched potency, selectivity and duration of action, however, their discovery is challenging. In principle, fragments that can irreversibly bind their target can overcome the low affinity that limits reversible fragment screening. Such electrophilic fragments were considered non-selective and were rarely screened. We hypothesized that mild electrophiles might overcome the selectivity challenge, and constructed a library of 993 mildly electrophilic fragments. We characterized this library by a new high-throughput thiol-reactivity assay and screened them against ten cysteine-containing proteins. Highly reactive and promiscuous fragments were rare and could be easily eliminated. By contrast, we found selective hits for most targets. Combination with high-throughput crystallography allowed rapid progression to potent and selective probes for two enzymes, the deubiquitinase OTUB2, and the pyrophosphatase NUDT7. No inhibitors were previously known for either. This study highlights the potential of electrophile fragment screening as a practical and efficient tool for covalent ligand discovery.

Introduction. Issues arising from the automatic monitoring of high-rise buildings are considered. One of such issues is the necessity of minimizing the number of sensors when taking the operational patterns of such load-bearing systems. The method of sensor placement in high-rise buildings is described. Materials and methods. Different structural systems of high-rise buildings have common dependencies of longitudinal axis deformation on rigidity of vertical and horizontal load-bearing elements. Calculation of deformations from static wind load, comparison of data obtained by manual and computer calculation, and also comparison of static wind load with the wind load pulsation component are performed. Results. From the analysis of the extrema of the deformation function of the building vertical axis with the horizontal plane of the floor structure preserved, the main typical monitoring points necessary to minimize the number of sensors in high-rise buildings were determined. Based on the typical breaking points, the required number of sensors located 1/4 of the building height away from each other and the range of measured values of deformations that occur during operation were determined. Conclusions. For automatic (constant) monitoring of high-rise buildings, it is advisable to use a complex integrated method of measuring deformations of vertical load-bearing structures, frequencies and amplitudes of oscillations, and rotation angles. According to the general design theory of high-rise buildings and computer calculation models, the most efficient placement of engineering structure monitoring sensors is when they are evenly covering the perimeter of each floor and the entire height of the building. Measurements should be carried out following the outlines of the floor structures on stories located 1/4 of the building height away from each other, as well as on the stiffening core to control the integrity of floor structures and their connection to the stiffness core.

Elucidating the physiological roles and modes of action of the recently discovered ligands (designated ALKAL1,2 or AUG-α,β) of the receptor tyrosine kinases Anaplastic Lymphoma Kinase (ALK) and Leukocyte Tyrosine Kinase (LTK) has been limited by difficulties in producing sufficient amounts of the two ligands and their poor stability. Here we describe procedures for expression and purification of AUG-α and a deletion mutant lacking the N-terminal variable region. Detailed biochemical characterization of AUG-α by mass spectrometry shows that the four conserved cysteines located in the augmentor domain (AD) form two intramolecular disulfide bridges while a fifth, primate-specific cysteine located in the N-terminal variable region mediates dimerization through formation of a disulfide bridge between two AUG-α molecules. In contrast to AUG-α, the capacity of AUG-α AD to undergo dimerization is strongly compromised. However, full-length AUG-α and the AUG-α AD deletion mutant stimulate similar tyrosine phosphorylation of cells expressing either ALK or LTK. Both AUG-α and AUG-α AD also stimulate a similar profile of MAP kinase response in L6 cells and colony formation in soft agar by autocrine stimulation of NIH 3T3 cells expressing ALK. Moreover, both AUG-α and AUG-α AD stimulate neuronal differentiation of human neuroblastoma NB1 and PC12 cells in a similar dose-dependent manner. Taken together, these experiments show that deletion of the N-terminal variable region minimally affects the activity of AUG-α toward LTK or ALK stimulation in cultured cells. Reduced dimerization might be compensated by high local concentration of AUG-α AD bound to ALK at the cell membrane and by potential ligand-induced receptor–receptor interactions.

Patients with both acute coronary syndromes (ACS) and congestive heart failure are at an increased risk of recurrent cardiovascular (CV) events attributed in part to both excess thrombin generation and impaired fibrinolysis. We hypothesized that patients with the overlap of ACS and CHF would thus derive particular benefit from antithrombotic therapy with rivaroxaban. ATLAS-ACS-2 Thrombolysis in Myocardial Infarction-51 was a double-blind, multicenter, phase 3 clinical trial that randomized patients within 7 days of an ACS event to standard of care plus either rivaroxaban 2.5 mg BID, 5 mg BID, or placebo (n = 15,526). In this post hoc subgroup analysis, subjects with a history of CHF at randomization (n = 1,694) were evaluated. Among subjects with a history of CHF, both rivaroxaban doses reduced the primary composite end point of CV death, myocardial infarction, or stroke (2.5 mg BID vs placebo: hazard ratio [HR] 0.59, 95% confidence interval [CI] (0.42, 0.81), p = 0.001; 5 mg BID vs placebo: HR 0.61, 95% CI (0.44, 0.84), p = 0.002; p interaction = 0.006). Both doses of rivaroxaban reduced CV mortality (rivaroxaban 2.5 mg BID vs placebo: 4.1% vs 9.0%, HR 0.45, 95% CI [0.27, 0.74], p = 0.002; rivaroxaban 5 mg BID vs placebo: 5.8% vs 9.0%, HR 0.62, 95% CI [0.40, 0.96], p = 0.031) as well as all-cause mortality. There was no significant increase in noncoronary artery bypass graft-related Thrombolysis in Myocardial Infarction major bleeding with either dose of rivaroxaban as compared with placebo (rivaroxaban 2.5 mg BID = 0.4% vs rivaroxaban 5 mg BID = 1.1% vs placebo = 0.5%). Rivaroxaban also did not increase either intracranial hemorrhage or fatal bleeding. In conclusion, in ACS subjects with a history of CHF, secondary prevention with rivaroxaban reduced the composite of CV death, myocardial infarction, or stroke without an increase in noncoronary artery bypass graft-related major bleeding. These findings require further prospective evaluation in an adequately powered phase 3 study.

The chapter presents a new approach to determining the strength of masonry reinforced with transverse meshes in mortar joints. The method consists of using the values of the modulus of elasticity and limiting deformations of the stone material, mortar for joints, and both steel and composite reinforcements. An analytical notation is proposed that integrally takes into account the characteristics of the initial materials. The results of physical tests of centrally loaded masonry pillars reinforced with steel and composite meshes are given. To test the masonry, widely used materials were used: solid brick and cement-sand mortar. The values of the bearing capacity, deformations, and internal stresses of the masonry are obtained. It is determined that the stresses in the reinforcing bars of the meshes are unevenly distributed in the horizontal plane of the mortar joint and amount to 20–37% of the design resistance of the mesh material. The strength of masonry reinforced with composite meshes is 65–75% of steel of the same cross section. It is shown that there is a good convergence of test results with the presented analytical dependence.

Background: Despite dual antiplatelet therapy, persistent thrombin generation and thrombin-mediated platelet activation account in part for the residual risk of atherothrombotic disease among patients with prior acute coronary syndrome (ACS). Inhibition of thrombin generation among high-risk ACS patients (biomarker-positive ACS) with the factor Xa inhibitor rivaroxaban may limit ongoing thrombus formation and myocardial necrosis and thereby improve clinical outcomes. Objectives and methods: ATLAS ACS 2-TIMI 51 was a double-blind, placebo-controlled clinical trial that randomized ACS patients to either rivaroxaban 2.5 mg b.i.d., rivaroxaban 5 mg b.i.d., or placebo plus standard-of-care antiplatelet therapy for a mean of 13.1 months and up to 31 months ( N=15,526). This post-hoc analysis evaluates the safety and efficacy of rivaroxaban among biomarker-positive ACS patients with and without a history of prior stroke of transient ischemic attack in the ATLAS ACS 2-TIMI 51 trial. Results: A total of 12,626 biomarker-positive ACS patients were included in this analysis. Among biomarker-positive patients without a prior history of stroke or transient ischemic attack, rivaroxaban 2.5 b.i.d. was associated with a reduction in the primary efficacy endpoint (composite of cardiovascular death, myocardial infarction, or stroke) as compared with placebo (hazard ratio=0.80, 95% confidence interval (0.68–0.94), p=0.007) at the expense of an increase in non-coronary-artery-bypass-graft-related Thrombolysis in Myocardial Infarction major bleeding (1.9% vs. 0.7%, pConclusion: Rivaroxaban 2.5 mg b.i.d. was associated with a significant reduction in the composite of cardiovascular death, myocardial infarction, or stroke with no increase in fatal bleeding. Biomarker-positive patients with no prior history of stroke or transient ischemic attack may be a optimal target population to receive “dual pathway” therapy with rivaroxaban plus dual antiplatelet therapy for secondary prevention following ACS.

Rolling the tube sheet of a heat exchanger with U-shaped tubes, as exemplified by the vapor cooler GP-24, was simulated. The simulation was performed using the finite element method with account of elas- tic–plastic properties of the tube and tube sheet materials. The simulation consisted of two stages; at the first stage, maximum and residual contact stress in the conjunction of a separate tube and the tube sheet was determined using the “equivalent sleeve” model; at the second stage, the obtained contact stress was applied to the hole surface in the tube sheet. Thus, different tube rolling sequences were simulated: from the center to the periphery of the tube sheet and from the periphery to the center along a spiral line. The studies showed that the tube rolling sequence noticeably influences the value of the tube sheet residual deflection for the same rolling parameters of separate tubes. Residual deflection of the tube sheet in different planes was determined. It was established that the smallest residual deflection corresponds to the tube rolling sequence from the periphery to the center of the tube sheet. The following dependences were obtained for different rolling sequences: maximum deformation of the tube sheet as a function of the number of rolled tubes, residual deformation of the tube sheet along its surface, and residual deflection of the tube sheet as a function of the rotation angle at the periphery. The preferred sequence of tube rolling for minimizing the tube sheet deformation is indicated.

The influence of heat treatment different options on wear resistance of steels of trademarks Kh12MFL and 150KhNML applied in manufacturing of mud pumps is reviewed. It is shown that the steel Kh12MFL is superior in wear resistance than the steel 150KhNML at abrasion. The martensite-carbide structure of both steels obtained at quenching at normal temperatures, from 900 to 1000 0С, ensures a good hardness (61-64 HRC). The analysis of the residual austenite contents influence on wear resistance was also made. It was determined that residual austenite formed after high temperature quenching (110-1170 0С) was metastable and had a tendency to transform into carbon containing martensite of deformation in the process abrasive wearing. This allowed steels to have a maximum wear resistance because of ensuring a high ability to frictional hardening of the working surface.

Summary. The concept of algorithmic models appeared from the algorithmic approach in which the simulated object, the phenomenon appears in the form of process, subject to strict rules of the algorithm, which placed the process of operation of the facility. Under the algorithmic model is the formalized description of the scenario subject specialist for the simulated process, the structure of which is comparable with the structure of the causal and temporal relationships between events of the process being modeled, together with all information necessary for its software implementation. To represent the structure of algorithmic models used algorithmic network. Normally, they were defined as loaded finite directed graph, the vertices which are mapped to operators and arcs are variables, bound by operators. The language of algorithmic networks has great features, the algorithms that it can display indifference the class of all random algorithms. In existing systems, automation modeling based on algorithmic nets, mainly used by operators working with real numbers. Although this reduces their ability, but enough for modeling a wide class of problems related to economy, environment, transport, technical processes. The task of modeling the execution of schedules and network diagrams is relevant and useful. There are many counting systems, network graphs, however, the monitoring process based analysis of gaps and terms of graphs, no analysis of prediction execution schedule or schedules. The library is designed to build similar predictive models. Specifying source data to obtain a set of projections from which to choose one and take it for a new plan.

The paper presents a theoretical study of three approaches to identifying the material stress-strain behaviour under the elastomer constrained bending. The relationships for determining the required tool pressure have been revealed. The results of an experimental study of constrained bending for the operating pressure of an elastic medium have proved to be the most close ones to the analytical studies for the plane stress behaviour of the workpiece material.