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1. A wiggling filamentary jet at the origin of the blazar multi-wavelength behaviour

Author

Raiteri, C. M., Villata, M., Carnerero, M. I., Kurtanidze, S. O., Mirzaqulov, D. O., Benítez, E., Bonnoli, G., Carosati, D., Acosta-Pulido, J. A., Agudo, I., Andreeva, T. S., Apolonio, G., Bachev, R., Borman, G. A., Bozhilov, V., Brown, L. F., Carbonell, W., Casadio, C., Chen, W. P., Damljanovic, G., Ehgamberdiev, S. A., Elsaesser, D., Escudero, J., Feige, M., Fuentes, A., Gabellini, D., Gazeas, K., Giroletti, M., Grishina, T. S., Gupta, A. C., Gurwell, M. A., Hagen-Thorn, V. A., Hamed, G. M., Hiriart, D., Hodges, M., ivanidze, R. Z., Ivanov, D. V., Joner, M. D., Jorstad, S. G., Jovanovic, M. D., Kiehlmann, S., Kimeridze, G. N., Kopatskaya, E. N., Kovalev, Yu. A., Kovalev, Y. Y., Kurtanidze, O. M., Kurtenkov, A., Larionova, E. G., Lessing, A., Lin, H. C., López, J. M., Lorey, C., Ludwig, J., Marchili, N., Marchini, A., Marscher, A. P., Matsumoto, K., Max-Moerbeck, W., Mihov, B., Minev, M., Mingaliev, M. G., Modaressi, A., Morozova, D. A., Mortari, F., Mufakharov, T. V., Myserlis, I., Nikolashvili, M. G., Pearson, T. J., Popkov, A. V., Rahimov, I. A., Readhead, A. C. S., Reinhart, D., Reeves, R., Righini, S., Romanov, F. D., Savchenko, S. S., Semkov, E., Shishkina, E. V., Sigua, L. A., Slavcheva-Mihova, L., Sotnikova, Yu. V., Steineke, R., Stojanovic, M., Strigachev, A., Takey, A., Traianou, E., Troitskaya, Yu. V., Troitskiy, I. S., Tsai, A. L., Valcheva, A., Vasilyev, A. A., Verna, G., Vince, O., Vrontaki, K., Weaver, Z. R., Webb, J., Yuldoshev, Q. X., Zaharieva, E., and Zhovtan, A. V.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

Blazars are beamed active galactic nuclei known for their strong multi-wavelength variability on timescales from years down to minutes. We aim to investigate the suitability of the twisting jet model presented in previous works to explain the multi-wavelength behaviour of BL Lacertae, the prototype of one of the blazar classes. According to this model, the jet is inhomogeneous, curved, and twisting, and the long-term variability is due to changes in the Doppler factor due to variations in the orientation of the jet-emitting regions. We analysed optical data of the source obtained during monitoring campaigns organised by the Whole Earth Blazar Telescope (WEBT) in 2019-2022, together with radio data from the WEBT and other teams, and gamma-ray data from the Fermi satellite. In this period, BL Lacertae underwent an extraordinary activity phase, reaching its historical optical and gamma-ray brightness maxima. The application of the twisting jet model to the source light curves allows us to infer the wiggling motion of the optical, radio, and gamma-ray jet-emitting regions. The optical-radio correlation shows that the changes in the radio viewing angle follow those in the optical viewing angle by about 120 days, and it suggests that the jet is composed of plasma filaments, which is in agreement with some radio high-resolution observations of other sources. The gamma-ray emitting region is found to be co-spatial with the optical one, and the analysis of the gamma-optical correlation is consistent with both the geometric interpretation and a synchrotron self-Compton (SSC) origin of the high-energy photons. We propose a geometric scenario where the jet is made up of a pair of emitting plasma filaments in a sort of double-helix curved rotating structure, whose wiggling motion produces changes in the Doppler beaming and can thus explain the observed multi-wavelength long-term variability., Comment: In press for A&A

Published
2024
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2. Multimessenger Characterization of Markarian 501 during Historically Low X-Ray and γ-Ray Activity

Author

H. Abe, S. Abe, V. A. Acciari, I. Agudo, T. Aniello, S. Ansoldi, L. A. Antonelli, A. Arbet-Engels, C. Arcaro, M. Artero, K. Asano, D. Baack, A. Babić, A. Baquero, U. Barres de Almeida, J. A. Barrio, I. Batković, J. Baxter, J. Becerra González, W. Bednarek, E. Bernardini, M. Bernardos, A. Berti, J. Besenrieder, W. Bhattacharyya, C. Bigongiari, A. Biland, O. Blanch, G. Bonnoli, Ž. Bošnjak, I. Burelli, G. Busetto, R. Carosi, M. Carretero-Castrillo, A. J. Castro-Tirado, G. Ceribella, Y. Chai, A. Chilingarian, S. Cikota, E. Colombo, J. L. Contreras, J. Cortina, S. Covino, G. D’Amico, V. D’Elia, P. Da Vela, F. Dazzi, A. De Angelis, B. De Lotto, A. Del Popolo, M. Delfino, J. Delgado, C. Delgado Mendez, D. Depaoli, F. Di Pierro, L. Di Venere, E. Do Souto Espiñeira, D. Dominis Prester, A. Donini, D. Dorner, M. Doro, D. Elsaesser, G. Emery, J. Escudero, V. Fallah Ramazani, L. Fariña, A. Fattorini, L. Foffano, L. Font, C. Fruck, S. Fukami, Y. Fukazawa, R. J. García López, M. Garczarczyk, S. Gasparyan, M. Gaug, J. G. Giesbrecht Paiva, N. Giglietto, F. Giordano, P. Gliwny, N. Godinović, R. Grau, D. Green, J. G. Green, D. Hadasch, A. Hahn, T. Hassan, L. Heckmann, J. Herrera, D. Hrupec, M. Hütten, R. Imazawa, T. Inada, R. Iotov, K. Ishio, I. Jiménez Martínez, J. Jormanainen, D. Kerszberg, Y. Kobayashi, H. Kubo, J. Kushida, A. Lamastra, D. Lelas, F. Leone, E. Lindfors, L. Linhoff, S. Lombardi, F. Longo, R. López-Coto, M. López-Moya, A. López-Oramas, S. Loporchio, A. Lorini, E. Lyard, B. Machado de Oliveira Fraga, P. Majumdar, M. Makariev, G. Maneva, N. Mang, M. Manganaro, S. Mangano, K. Mannheim, M. Mariotti, M. Martínez, A. Mas-Aguilar, D. Mazin, S. Menchiari, S. Mender, S. Mićanović, D. Miceli, T. Miener, J. M. Miranda, R. Mirzoyan, E. Molina, H. A. Mondal, A. Moralejo, D. Morcuende, V. Moreno, T. Nakamori, C. Nanci, L. Nava, V. Neustroev, M. Nievas Rosillo, C. Nigro, K. Nilsson, K. Nishijima, T. Njoh Ekoume, K. Noda, S. Nozaki, Y. Ohtani, T. Oka, A. Okumura, J. Otero-Santos, S. Paiano, M. Palatiello, D. Paneque, R. Paoletti, J. M. Paredes, L. Pavletić, M. Persic, M. Pihet, G. Pirola, F. Podobnik, P. G. Prada Moroni, E. Prandini, G. Principe, C. Priyadarshi, W. Rhode, M. Ribó, J. Rico, C. Righi, A. Rugliancich, N. Sahakyan, T. Saito, S. Sakurai, K. Satalecka, F. G. Saturni, B. Schleicher, K. Schmidt, F. Schmuckermaier, J. L. Schubert, T. Schweizer, J. Sitarek, V. Sliusar, D. Sobczynska, A. Spolon, A. Stamerra, J. Strišković, D. Strom, M. Strzys, Y. Suda, T. Surić, H. Tajima, M. Takahashi, R. Takeishi, F. Tavecchio, P. Temnikov, K. Terauchi, T. Terzić, M. Teshima, L. Tosti, S. Truzzi, A. Tutone, S. Ubach, J. van Scherpenberg, M. Vazquez Acosta, S. Ventura, V. Verguilov, I. Viale, C. F. Vigorito, V. Vitale, I. Vovk, R. Walter, M. Will, C. Wunderlich, T. Yamamoto, D. Zarić, The MAGIC Collaboration, M. Cerruti, J. A. Acosta-Pulido, G. Apolonio, R. Bachev, M. Baloković, E. Benítez, I. Björklund, V. Bozhilov, L. F. Brown, A. Bugg, W. Carbonell, M. I. Carnerero, D. Carosati, C. Casadio, W. Chamani, W. P. Chen, R. A. Chigladze, G. Damljanovic, K. Epps, A. Erkenov, M. Feige, J. Finke, A. Fuentes, K. Gazeas, M. Giroletti, T. S. Grishina, A. C. Gupta, M. A. Gurwell,, E. Heidemann, D. Hiriart, W. J. Hou, T. Hovatta, S. Ibryamov, M. D. Joner, S. G. Jorstad, J. Kania, S. Kiehlmann, G. N. Kimeridze, E. N. Kopatskaya, M. Kopp, M. Korte, B. Kotas, S. Koyama, J. A. Kramer, L. Kunkel, S. O. Kurtanidze, O. M. Kurtanidze, A. Lähteenmäki, J. M. López, V. M. Larionov, E. G. Larionova, L. V. Larionova, C. Leto, C. Lorey, R. Mújica, G. M. Madejski, N. Marchili, A. P. Marscher, M. Minev, A. Modaressi, D. A. Morozova, T. Mufakharov, I. Myserlis, A. A. Nikiforova, M. G. Nikolashvili, E. Ovcharov, M. Perri, C. M. Raiteri, A. C. S. Readhead, A. Reimer, D. Reinhart, S. Righini, K. Rosenlehner, A. C. Sadun, S. S. Savchenko, A. Scherbantin, L. Schneider, K. Schoch, D. Seifert, E. Semkov, L. A. Sigua, C. Singh, P. Sola, Y. Sotnikova, M. Spencer, R. Steineke, M. Stojanovic, A. Strigachev, M. Tornikoski, E. Traianou, A. Tramacere, Yu. V. Troitskaya, I. S. Troitskiy, J. B. Trump, A. Tsai, A. Valcheva, A. A. Vasilyev, F. Verrecchia, M. Villata, O. Vince, K. Vrontaki, Z. R. Weaver, E. Zaharieva, and N. Zottmann

Subjects
Active galaxies, BL Lacertae objects, Markarian galaxies, Active galactic nuclei, Blazars, Astrophysics, QB460-466
Abstract

We study the broadband emission of Mrk 501 using multiwavelength observations from 2017 to 2020 performed with a multitude of instruments, involving, among others, MAGIC, Fermi's Large Area Telescope (LAT), NuSTAR, Swift, GASP-WEBT, and the Owens Valley Radio Observatory. Mrk 501 showed an extremely low broadband activity, which may help to unravel its baseline emission. Nonetheless, significant flux variations are detected at all wave bands, with the highest occurring at X-rays and very-high-energy (VHE) γ -rays. A significant correlation (>3 σ ) between X-rays and VHE γ -rays is measured, supporting leptonic scenarios to explain the variable parts of the emission, also during low activity. This is further supported when we extend our data from 2008 to 2020, and identify, for the first time, significant correlations between the Swift X-Ray Telescope and Fermi-LAT. We additionally find correlations between high-energy γ -rays and radio, with the radio lagging by more than 100 days, placing the γ -ray emission zone upstream of the radio-bright regions in the jet. Furthermore, Mrk 501 showed a historically low activity in X-rays and VHE γ -rays from mid-2017 to mid-2019 with a stable VHE flux (>0.2 TeV) of 5% the emission of the Crab Nebula. The broadband spectral energy distribution (SED) of this 2 yr long low state, the potential baseline emission of Mrk 501, can be characterized with one-zone leptonic models, and with (lepto)-hadronic models fulfilling neutrino flux constraints from IceCube. We explore the time evolution of the SED toward the low state, revealing that the stable baseline emission may be ascribed to a standing shock, and the variable emission to an additional expanding or traveling shock.

Published
2023
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4. Critical Race Mixed Methodology (CRMM) as a transformative method: The benefits and challenges

Author

Jessica T. DeCuir-Gunby, Whitney N. McCoy, and Saba L. Modaressi

Subjects
Mixed methods, Critical race theory, Transformative methods, African Americans, Psychology, BF1-990
Abstract

Critical Race Mixed Methodology (CRMM) is a transformative mixed methods approach that combines CRT within a mixed methods design. In this article, we reflect upon our experience using and publishing a CRMM explanatory mixed methods study in a higher education journal's special issue focused on mixed methods research. We discuss the benefits of using CRMM as a transformative method. Then, we share the challenges of using CRMM. We also provide recommendations for engaging in CRMM research within psychology.

Published
2024
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5. Multi-messenger characterization of Mrk 501 during historically low X-ray and $\gamma$-ray activity

Author

MAGIC collaboration, Abe, H., Abe, S., Acciari, V. A., Agudo, I., Aniello, T., Ansoldi, S., Antonelli, L. A., Engels, A. Arbet, Arcaro, C., Artero, M., Asano, K., Baack, D., Babić, A., Baquero, A., de Almeida, U. Barres, Barrio, J. A., Batković, I., Baxter, J., González, J. Becerra, Bednarek, W., Bernardini, E., Bernardos, M., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Bošnjak, Ž., Burelli, I., Busetto, G., Carosi, R., Carretero-Castrillo, M., Castro-Tirado, A. J., Ceribella, G., Chai, Y., Chilingarian, A., Cikota, S., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Amico, G., D'Elia, V., Da Vela, P., Dazzi, F., De Angelis, A., De Lotto, B., Del Popolo, A., Delfino, M., Delgado, J., Mendez, C. Delgado, Depaoli, D., Di Pierro, F., Di Venere, L., Espiñeira, E. Do Souto, Prester, D. Dominis, Donini, A., Dorner, D., Doro, M., Elsaesser, D., Emery, G., Escudero, J., Ramazani, V. Fallah, Fariña, L., Fattorini, A., Foffano, L., Font, L., Fruck, C., Fukami, S., Fukazawa, Y., López, R. J. García, Garczarczyk, M., Gasparyan, S., Gaug, M., Paiva, J. G. Giesbrecht, Giglietto, N., Giordano, F., Gliwny, P., Godinović, N., Grau, R., Green, D., Green, J. G., Hadasch, D., Hahn, A., Hassan, T., Heckmann, L., Herrera, J., Hrupec, D., Hütten, M., Imazawa, R., Inada, T., Iotov, R., Ishio, K., Martínez, I. Jiménez, Jormanainen, J., Kerszberg, D., Kobayashi, Y., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Linhoff, L., Lombardi, S., Longo, F., López-Coto, R., López-Moya, M., López-Oramas, A., Loporchio, S., Lorini, A., Lyard, E., Fraga, B. Machado de Oliveira, Majumdar, P., Makariev, M., Maneva, G., Mang, N., Manganaro, M., Mangano, S., Mannheim, K., Mariotti, M., Martínez, M., Mas-Aguilar, A., Mazin, D., Menchiari, S., Mender, S., Mićanović, S., Miceli, D., Miener, T., Miranda, J. M., Mirzoyan, R., Molina, E., Mondal, H. A., Moralejo, A., Morcuende, D., Moreno, V., Nakamori, T., Nanci, C., Nava, L., Neustroev, V., Rosillo, M. Nievas, Nigro, C., Nilsson, K., Nishijima, K., Ekoume, T. Njoh, Noda, K., Nozaki, S., Ohtani, Y., Oka, T., Okumura, A., Otero-Santos, J., Paiano, S., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Pavletić, L., Persic, M., Pihet, M., Pirola, G., Podobnik, F., Moroni, P. G. Prada, Prandini, E., Principe, G., Priyadarshi, C., Rhode, W., Ribó, M., Rico, J., Righi, C., Rugliancich, A., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Saturni, F. G., Schleicher, B., Schmidt, K., Schmuckermaier, F., Schubert, J. L., Schweizer, T., Sitarek, J., Sliusar, V., Sobczynska, D., Spolon, A., Stamerra, A., Strišković, J., Strom, D., Strzys, M., Suda, Y., Surić, T., Tajima, H., Takahashi, M., Takeishi, R., Tavecchio, F., Temnikov, P., Terauchi, K., Terzić, T., Teshima, M., Tosti, L., Truzzi, S., Tutone, A., Ubach, S., van Scherpenberg, J., Acosta, M. Vazquez, Ventura, S., Verguilov, V., Viale, I., Vigorito, C. F., Vitale, V., Vovk, I., Walter, R., Will, M., Wunderlich, C., Yamamoto, T., Zarić, D., groups, Other, collaborations, Cerruti, M., Acosta-Pulido, J. A., Apolonio, G., Bachev, R., Baloković, M., Benítez, E., Björklund, I., Bozhilov, V., Brown, L. F., Bugg, A., Carbonell, W., Carnerero, M. I., Carosati, D., Casadio, C., Chamani, W., Chen, W. P., Chigladze, R. A., Damljanovic, G., Epps, K., Erkenov, A., Feige, M., Finke, J., Fuentes, A., Gazeas, K., Giroletti, M., Grishina, T. S., Gupta, A. C., Gurwell, M. A., Heidemann, E., Hiriart, D., Hou, W. J., Hovatta, T., Ibryamov, S., Joner, M. D., Jorstad, S. G., Kania, J., Kiehlmann, S., Kimeridze, G. N., Kopatskaya, E. N., Kopp, M., Korte, M., Kotas, B., Koyama, S., Kramer, J. A., Kunkel, L., Kurtanidze, S. O., Kurtanidze, O. M., Lähteenmäki, A., López, J. M., Larionov, V. M., Larionova, E. G., Larionova, L. V., Leto, C., Lorey, C., Mújica, R., Madejski, G. M., Marchili, N., Marscher, A. P., Minev, M., Modaressi, A., Morozova, D. A., Mufakharov, T., Myserlis, I., Nikiforova, A. A., Nikolashvili, M. G., Ovcharov, E., Perri, M., Raiteri, C. M., Readhead, A. C. S., Reimer, A., Reinhart, D., Righini, S., Rosenlehner, K., Sadun, A. C., Savchenko, S. S., Scherbantin, A., Schneider, L., Schoch, K., Seifert, D., Semkov, E., Sigua, L. A., Singh, C., Sola, P., Sotnikova, Y., Spencer, M., Steineke, R., Stojanovic, M., Strigachev, A., Tornikoski, M., Traianou, E., Tramacere, A., Troitskaya, Yu. V., Troitskiy, I. S., Trump, J. B., Tsai, A., Valcheva, A., Vasilyev, A. A., Verrecchia, F., Villata, M., Vince, O., Vrontaki, K., Weaver, Z. R., Zaharieva, E., and Zottmann, N.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

We study the broadband emission of Mrk 501 using multi-wavelength observations from 2017 to 2020 performed with a multitude of instruments, involving, among others, MAGIC, Fermi-LAT, NuSTAR, Swift, GASP-WEBT, and OVRO. Mrk 501 showed an extremely low broadband activity, which may help to unravel its baseline emission. Nonetheless, significant flux variations are detected at all wavebands, with the highest occurring at X-rays and very-high-energy (VHE) $\gamma$-rays. A significant correlation ($>$3$\sigma$) between X-rays and VHE $\gamma$-rays is measured, supporting leptonic scenarios to explain the variable parts of the emission, also during low activity. This is further supported when we extend our data from 2008 to 2020, and identify, for the first time, significant correlations between Swift-XRT and Fermi-LAT. We additionally find correlations between high-energy $\gamma$-rays and radio, with the radio lagging by more than 100 days, placing the $\gamma$-ray emission zone upstream of the radio-bright regions in the jet. Furthermore, Mrk 501 showed a historically low activity in X-rays and VHE $\gamma$-rays from mid-2017 to mid-2019 with a stable VHE flux ($>$0.2 TeV) of 5% the emission of the Crab Nebula. The broadband spectral energy distribution (SED) of this 2-year-long low-state, the potential baseline emission of Mrk 501, can be characterized with one-zone leptonic models, and with (lepto)-hadronic models fulfilling neutrino flux constraints from IceCube. We explore the time evolution of the SED towards the low-state, revealing that the stable baseline emission may be ascribed to a standing shock, and the variable emission to an additional expanding or traveling shock., Comment: 55 pages, 30 figures, 14 tables, accepted by APJS. Corresponding authors are L. Heckmann, D. Paneque, S. Gasparyan, M. Cerruti, and N. Sahakyan

Published
2022
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9. Conceptualization of Motion in Persian Compound Verbs: A Cognitive Approach

Author

Beheshte Ozgoli, Hayat Ameri, and Bahram Modaressi

Subjects
cognitive linguistics, compound verbs, motion verbs, lexicalization, lexicalization compound verb, Language and Literature
Abstract

Motion is considered as a fundamental concept in human cognitive system that could be represented in all languages differently. The present paper is going to explain that how lexicalization happens in motion compound verbs. This research is analytical descriptive, and is going to study the lexical meaning of the none-verbal elements and main verb elements such as (do, give, become, hit, eat, go, take, come, pull) according to Talmy’s theory(1985) ,and to find the amount of lexicalization of these verbs in Persian language which is divided into verb-framed and satellite-framed combined verbs. Another aim is to show the semantic meaning between its constructions. Thus, 100 combined verbs collected as non-head framed construction which consisted of mentioned verbs from Fargang-e-Sokhan (Anvari,1381). The results indicate that lexicalization happens both in root and satellite. It also shows that the meaning components of each head framed construction causes that special satellite accompanied with the mentioned verbs, thus the more fertility in satellite, the more lexicalization. Other results show that Persian compound verbs are more satellite-framed than verb-framed. Another result shows that according to Slobin’s theory (1960), speakers of verb-based languages as persian languags languages tend to remove the component of path in sentences.

Published
2022
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10. Numerical Black Hole Solutions For A Timelike Bumblebee Field

Author

Modaressi, Azadé and Modaressi, Azadé

Abstract

This work builds on a paper by Casana et al. [1], in which they calculated an exact, spherically symmetric solution to the Einstein equations in the presence of a bumblebee vector field. We extend their solutions by introducing a timelike component to the vector field. We are able to obtain series solutions to the Einstein equation in the presence of this field. We then demonstrate that these solutions recover flat spacetime. Our results cast doubt on the physical viability of this model, but a more thorough proof is required.

Published
2024

14. Is the friction angle the maximum slope of a free surface of a non cohesive material?

Author

Modaressi, A. and Evesque, P.

Subjects
Condensed Matter - Soft Condensed Matter
Abstract

Starting from a symmetric triangular pile with a horizontal basis and rotating the basis in the vertical plane, we have determined the evolution of the stress distribution as a function of the basis inclination using Finite Elements method with an elastic-perfectly plastic constitutive model, defined by its friction angle, without cohesion. It is found that when the yield function is the Drucker-Prager one, stress distribution satisfying equilibrium can be found even when one of the free-surface slopes is larger than the friction angle. This means that piles with a slope larger than the friction angle can be (at least) marginally stable and that slope rotation is not always a destabilising perturbation direction. On the contrary, it is found that the slope cannot overpass the friction angle when a Mohr-Coulomb yield function is used. Theoretical explanation of these facts is given which enlightens the role plaid by the intermediate principal stress in both cases of the Mohr-Coulomb criterion and of the Drucker-Prager one. It is then argued that the Mohr-Coulomb criterion assumes a spontaneous symmetry breaking, as soon as the two smallest principal stresses are different ; this is not physical most likely; so this criterion shall be replaced by a Drucker-Prager criterion in the vicinity of the equality, which leads to the previous anomalous behaviour ; so these numerical computations enlighten the avalanche process: they show that no dynamical angle larger than the static one is needed to understand avalanching. It is in agreement with previous experimental results. Furthermore, these results show that the maximum angle of repose can be modified using cyclic rotations; we propose a procedure that allows to achieve a maximum angle of repose to be equal to the friction angle ., Comment: 21 pages + 1 page, 12 figures

Published
2005

15. The identification and characterisation of genes expressed in adult human testis

Author

Modaressi, Mohammad Hussein

Subjects
572.8, Genetics
Abstract

By the identification and isolation of cDNAs expressed specifically in the human testis I aimed to identify novel genes involved in spermatogenesis and/or spermiogenesis. Using Differential Display Reverse Transcriptase-PCR (DDRT-PCR) on RNA from a range of tissues which were selected to be logically related to testis functions I isolated a number of short cDNA fragments. Tissue-specific expression was confirmed by using RT-PCR with gene-specific primers. Three genes were examined in detail: Entire transcripts were sequenced by primer walking along cDNA templates generated by 5'RACE and the size of full-length cDNAs was confirmed by Northern analysis. The chromosomal locations of the genes were determined by two methods. Firstly by PCR amplification using gene specific primers of a panel of rodent somatic cell hybrids that each contain a single human chromosome Secondly, genomic clones (BAC or a PAC) were hybridised in situ to human metaphase chromosomes (FISH). Using the BAC clones, some genomic gene structure was determined. In this way I have isolated and characterised three novel genes from testis, TSGA10, GNG2 and T2G3. Testis Specific Gene A10 (TSGA10) is not expressed in a variety of tissues functionally related to testis nor is it expressed in either testes of two infertile patients or in foetal testis. The TSGA10 gene (GenBank Accession no. AF254756) consists of 3038 nucleotides spread over 19 exons and contains an open reading frame of 698 amino acids and one alternative splice site. RT-PCR results using RNA prepared from foetal and tumour tissues showed that transcripts from this gene are also present in squamous cell carcinoma, parotid and thyroid tumours, benign prostate hypertrophy and almost all foetal tissues though with different levels of expression in different tissues. Several ESTs with almost 100% homology to the TSGA10 transcript exist in the databases but all are probably derived from testis apart from three which were isolated from tumour tissues. This pattern of expression suggests that TSGA10 has a role in actively dividing cells and possibly in cell division and mitosis. The mouse homologue of this gene was also cloned and characterised. The gene GNG2 is a G protein subunit. The gene T2G3 is another novel gene. Both have been characterised to a lesser extent than TSGA10.

Published
2001

17. Assessment of physical activity of students at basic medical sciences of Shahid Sadoughi University of Medical Sciences in academic year 2015-2016

Author

Arezoo Aghakoochak, Mahmood Vakili, Elham alsadat Hashemi, and Mozhgan Modaressi

Subjects
physical activity, students, ipaq, Medicine, Medicine (General), R5-920, Psychology, BF1-990
Abstract

Introduction: Physical inactivity has been linked with many non-communicable diseases and it is now a major health problem in many countries. The aim of this research was to study the level of physical activity in the students at basic medical ssciences in Yazd Shahid Sadoughi University of Medical Sciences. Methods: This research was a cross sectional-descriptive study and its sampling method was census. The number of students from Yazd Shahid Sadoughi University of Medical Sciences at basic medical sciences who consented to participate in the study was 220. The International Physical Activity Questionnaire (long form) was used to collect data. SPSS version 16 was used for analysis of the obtained data. The significance level was considered less than 0.05. Results: From 221students attending this project, 36 (16.3%) students were males and 185 were females. In this study, 33.5% (74 students), 61.5% (136 students) and 5% (11 students) had, respectively, low, moderate and severe physical activity. Moreover, there was a significant relationship between physical activity and body mass index (P=0.003) and life location (P=0.012) and gender (P=0.001). Conclusion: Approximately one third (33.4%) of the students had low physical activity and moderate and severe physical activity was more than the female students. It seems that some interventions should be designed for increasing the level of physical activity among the students in order to determine the current status and present solutions for improving the present situation.

Published
2017

18. Proceedings of the 23rd Paediatric Rheumatology European Society Congress: part two

Author

Olga Lomakina, Ekaterina Alekseeva, Sania Valieva, Tatiana Bzarova, Irina Nikishina, Elena Zholobova, Svetlana Rodionovskaya, Maria Kaleda, Yasuo Nakagishi, Masaki Shimizu, Mao Mizuta, Akihiro Yachie, Yuko Sugita, Nami Okamoto, Kousuke Shabana, Takuji Murata, Hiroshi Tamai, Eve M. Smith, Peng Yin, Andrea L. Jorgensen, Michael W. Beresford, on behalf of On behalf of the UK JSLE Cohort Study, Antonio Eleuteri, Beatrice Goilav, Laura Lewandowski, Angel Phuti, Dawn Wahezi, Tamar Rubinstein, Caroline Jones, Paul Newland, Stephen Marks, Rachel Corkhill, Diana Ekdawy, Clarissa Pilkington, Kjell Tullus, Chaim Putterman, Chris Scott, Antony C. Fisher, Andrea Jorgensen, Ezgi Deniz Batu, Can Kosukcu, Ekim Taskiran, Sema Akman, Kubra Ozturk, Betul Sozeri, Erbil Unsal, Zelal Ekinci, Yelda Bilginer, Mehmet Alikasifoglu, Seza Ozen, Hanna Lythgoe, Hermine I. Brunner, Gaurav Gulati, Jordan T. Jones, Mekibib Altaye, Jamie Eaton, Mark Difrancesco, Joo Guan Yeo, Jingyao Leong, Loshinidevi D/O Thana Bathi, Thaschawee Arkachaisri, Salvatore Albani, Nagla Abdelrahman, Michael W Beresford, Valentina Leone, UK JSLE study group supported by the National Institute of Health Research Clinical Research Network, Noortje Groot, D. Shaikhani, I. E. M. Bultink, M. Bijl, R. J. E. M. Dolhain, Y. K. O. Teng, E. Zirkzee, K. de Leeuw, R. Fritsch-Stork, S. S. M. Kamphuis, Rachael D. Wright, Reem Abdawani, Laila Al Shaqshi, Ibrahim Al Zakwani, Natali W. Gormezano, David Kern, Oriany L. Pereira, Gladys C. C. Esteves, Adriana M. Sallum, Nadia E. Aikawa, Rosa M. Pereira, Clovis A. Silva, Eloisa Bonfa, Jessica Beckmann, Nora Bartholomä, Nils Venhoff, Philipp Henneke, Ulrich Salzer, Ales Janda, Alina Lucica Boteanu, Sandra Garrote Corral, Alberto Sifuentes Giraldo, Mariluz Gámir Gámir, Antonio Zea Mendoza, Amra Adrovic, Reyhan Dedeoglu, Sezgin Sahin, Kenan Barut, Aida Koka, Funda Oztunc, Ozgur Kasapcopur, Ana Luisa Rodriguez-Lozano, Francisco Rivas-Larrauri, Silvestre García de la Puente, Andressa G. F. Alves, Maria F. D. A. Giacomin, Juliana Farhat, Alfésio L. F. Braga, Adriana M. E. Sallum, Lúcia M. D. A. Campos, Luiz A. A. Pereira, Ana J. D. F. C. Lichtenfels, Clóvis A. Silva, Sylvia C. L. Farhat, Banu Acar, Z. Birsin Ozcakar, Nilgün Çakar, Nermin Uncu, Gökçe Gür, Semanur Özdel, Fatoş Yalçınkaya, Christiaan Scott, Nicky Brice, Peter Nourse, Christine Arango, Angela C. Mosquera, Clara Malagon, Ana P. Sakamoto, Marco F. C. D. Silva, Ananadreia S. Lopes, Gleice C. S. Russo, Adriana E. M. Sallum, Katia Kozu, Eloisa Bonfá, Claudia Saad-Magalhães, Rosa M. R. Pereira, Claudio A. Len, Maria T. Terreri, Deepti Suri, Siyaram Didel, Amit Rawat, Surjit Singh, Despoina Maritsi, MArgarita Onoufriou, Olga Vougiouka, Maria Tsolia, Edi Paleka Bosak, Mandica Vidović, Mirta Lamot, Lovro Lamot, Miroslav Harjaček, Erika Van Nieuwenhove, Adrian Liston, Carine Wouters, Fatemeh Tahghighi, Vahid Ziaee, Seid-Reza Raeeskarami, Francisca Aguiar, Sandra Pereira, Mariana Rodrigues, Cláudia Moura, Gustavo Rocha, Hercília Guimarães, Iva Brito, Rita Fonseca, Gerd Horneff, Ariane Klein, Kirsten Minden, Hans-Iko Huppertz, Frank Weller-Heinemann, Jasmin Kuemmerle-Deschner, J-Peter Haas, Anton Hospach, BIKER collaborative group, Ricardo Menendez-Castro, Boris Huegle, Johannes-Peter Haas, Joost Swart, Gabriella Giancane, Francesca Bovis, Elio Castagnola, Andreas Groll, Daniel J. Lovell, Tom Wolfs, Michael Hofer, Violeta Panaviene, Susan Nielsen, Jordi Anton, Florence Uettwiller, Valda Stanevicha, Maria Trachana, Denise Pires Marafon, Constantin Ailioaie, Elena Tsitsami, Sylvia Kamphuis, Troels Herlin, Pavla Doležalová, Gordana Susic, Berit Flatø, Flavio Sztajnbok, Angela Pistorio, Alberto Martini, Nico Wulffraat, Nicolino Ruperto, Marco Gattorno, Antonio Brucato, Martina Finetti, George Lazaros, Silvia Maestroni, Mara Carraro, Davide Cumetti, Alessandra Carobbio, Monia Lorini, Alessandro Rimini, Renzo Marcolongo, Anna Valenti, Gian Luca Erre, Riccardo Belli, Fiorenzo Gaita, Maria Pia Sormani, Massimo Imazio, Mario Abinun, Nicola Smith, Tim Rapley, Flora McErlane, Lianne Kearsley-Fleet, Kimme L. Hyrich, Helen Foster, Nikolay Tzaribachev, Andrew Zeft, Rolando Cimaz, John Bohnsack, Thomas Griffin, Ruy Carrasco, Jason Dare, Ivan Foeldvari, Richard Vehe, Teresa Simon, Hermine Brunner, S. Verazza, S. Davì, A. Consolaro, A. Insalaco, V. Gerloni, R. Cimaz, F. Zulian, S. Pastore, F. Corona, G. Conti, P. Barone, M. Cattalini, E. Cortis, L. Breda, A. N. Olivieri, A. Civino, R. Podda, D. Rigante, F. La Torre, G. D’Angelo, M. Jorini, R. Gallizzi, M. C. Maggio, R. Consolini, A. De Fanti, M. G. Alpigiani, A. Martini, A. Ravelli, on behalf of Italian Pediatric Rheumatology Study Group, Aysenur Pac Kısaarslan, Zubeyde Gunduz, Ruhan Dusunsel, Ismail Dursun, Hakan Poyrazoglu, Ekaterina Kuchinskaya, Farida Abduragimova, Mikhail Kostik, Erik Sundberg, Soley Omarsdottir, Lena Klevenvall, Helena Erlandsson-Harris, Gokalp Basbozkurt, Ozge Erdemli, Dogan Simsek, Fatih Yazici, Yildirim Karsioglu, Aysen Tezcaner, Dilek Keskin, Huseyin Ozkan, Cengizhan Acikel, Erkan Demirkaya, Ilonka Orbán, Krisztina Sevcic, Valentin Brodszky, Emese Kiss, Ismaiel A. Tekko, Madeleine Rooney, James McElnay, Cliff Taggart, Helen McCarthy, Ryan F. Donnelly, Drug Delivery Group, Mary Slatter, Zohreh Nademi, Mark Friswell, Sharmila Jandial, Terence Flood, Sophie Hambleton, Andrew Gennery, Andrew Cant, Phoi-Ngoc Duong, Isabelle Koné-Paut, Giovanni Filocamo, María Luz Gamir, Helga Sanner, Laura Carenini, Mesut Topdemir, Yildirim Karslioglu, Faysal Gok, Nadezhda Tsurikova, Elena Ligostaeva, Navdha R. Ramchurn, O. Kostareva, I. Nikishina, S. Arsenyeva, S. Rodionovskaya, M. Kaleda, D. Alexeev, Ismail Dursun Dursun, Sara Murias, Estefania Barral, Rosa Alcobendas, Eugenia Enriquez, Agustin Remesal, Jaime de Inocencio, Tania M. Castro, Simone A. Lotufo, Tatjana Freye, Raffaella Carlomagno, Thomas Zumbrunn, Jan Bonhoeffer, Elvira Cannizzaro Schneider, Daniela Kaiser, Michaël Hofer, Véronique Hentgen, Andreas Woerner, Juvenile Inflammatory Rheumatism (JIR) Cohort, Tobias Schwarz, Jens Klotsche, Martina Niewerth, Gerd Ganser, ICON study group, Jerold Jeyaratnam, Nienke ter Haar, Donato Rigante, Fatma Dedeoglu, Ezgi Baris, Sebastiaan Vastert, Joost Frenkel, Jonathan S. Hausmann, Kathleen G. Lomax, Ari Shapiro, Karen L. Durrant, P. A. Brogan, M. Hofer, J. B. Kuemmerle-Deschner, B. Lauwerys, A. Speziale, K. Leon, X. Wei, R. M. Laxer, Sara Signa, Marta Rusmini, Elena Campione, Sabrina Chiesa, Alice Grossi, Alessia Omenetti, Roberta Caorsi, Gianmaria Viglizzo, Isabella Ceccherini, Silvia Federici, Helen Lachmann, Nicola Ruperto, on behalf of PRINTO and Eurofever Registry, Federica Vanoni, on behalf of PRINTO and Eurofever Project, Sonia Melo Gomes, Ebun Omoyinmi, Juan I. Arostegui, Eva Gonzalez-Roca, Despina Eleftheriou, Nigel Klein, Paul Brogan, Stefano Volpi, Elettra Santori, Paolo Picco, Claudia Pastorino, Gillian Rice, Alessandra Tesser, Yanick Crow, Fabio Candotti, Ada B. Sinoplu, Gozde Yucel, Gizem Pamuk, Laura O. Damian, Cecilia Lazea, Mihaela Sparchez, Paulina Vele, Laura Muntean, Adriana Albu, Simona Rednic, Calin Lazar, Leonardo O. Mendonça, Alessandra Pontillo, Jorge Kalil, Fabio M. Castro, Myrthes T. Barros, Manuela Pardeo, Virginia Messia, Fabrizio De Benedetti, Antonella Insalaco, Giorgia Malighetti, Chiara Gorio, Francesca Ricci, Ilaria Parissenti, Paola Montesano, Barbara Bonafini, Veronica Medeghini, Marco Cattalini, Lucio Giordano, Giulia Zani, Rosalba Ferraro, Donatella Vairo, Silvia Giliani, Maria Cristina Maggio, Girolamo Luppino, Giovanni Corsello, Maria Isabel Gonzalez Fernandez, Berta Lopez Montesinos, Adriana Rodriguez Vidal, Juan I. Arostegui Gorospe, Inmaculada Calvo Penades, Nadia K. Rafiq, Karen Wynne, Khalid Hussain, Paul A. Brogan, Elizabeth Ang, Nicholas Ng, Ayla Kacar, Ozge Altug Gucenmez, Balahan Makay, Sevket Erbil Unsal, Yasin Sahin, Tufan Kutlu, Fugen Cullu-Cokugras, Hasret Ayyildiz-Civan, Tulay Erkan, Sana Al Zuhbi, Eiman Abdalla, Ricardo A. Russo, María M. Katsicas, Francesca Minoia, Angelo Ravelli, Sagar Bhattad, Anju Gupta, Vignesh Pandiarajan, Ritambhra Nada, Kaara Tiewsoh, Philip Hawkins, Dorota Rowczenio, Sarka Fingerhutova, Jana Franova, Leona Prochazkova, Eva Hlavackova, Pavla Dolezalova, Havva Evrengül, Selçuk Yüksel, Mustafa Doğan, Dolunay Gürses, Harun Evrengül, Silvia De Pauli, Serena Pastore, Anna Monica Bianco, Giovanni Maria Severini, Andrea Taddio, Alberto Tommasini, Svetlana O. Salugina, Evgeny Fedorov, Elena Kamenets, Ekaterina Zaharova, Tatiana Sleptsova, Ekaterina Alexeeva, Kirill Savostyanov, Alexander Pushkov, Tatyana Bzarova, Saniya Valieva, Rina Denisova, Kseniya Isayeva, Evgeniya Chistyakova, Margarita Soloshenko, Elena Kaschenko, Utako Kaneko, Chihaya Imai, Akihiko Saitoh, Vitor A. Teixeira, Filipa O. Ramos, Manuela Costa, Yonatan Butbul Aviel, Shafe Fahoum, Riva Brik, Zeynep Birsin Özçakar, Banu Acar Celikel, Fatos Yalcinkaya, Benedetta Schiappapietra, Sergio Davi’, Federica Mongini, Luisa Giannone, Cecilia Bava, Maria Giannina Alpigiani, Alessandro Consolaro, Dragana S. Lazarevic, Jelena Vojinovic, Jelena Basic, Valentina Muratore, Valentina Marzetti, Neus Quilis, Belen Serrano Benavente, Alessandra Alongi, Adele Civino, Lorenzo Quartulli, Giedre Januskeviciute, Pieter van Dijkhuizen, N. Groot, W. van Dijk, A. Kardolus, Raul Gutiérrez Suárez, Ellen B. Nordal, Veronika G. Rypdal, Lillemor Berntson, Maria Ekelund, Kristiina Aalto, Suvi Peltoniemi, Marek Zak, Mia Glerup, Ellen D. Arnstad, Anders Fasth, Marite Rygg, the Nordic Study Group of Pediatric Rheumatology (NoSPeR), Ana Catarina Duarte, Sandra Sousa, Lídia Teixeira, Ana Cordeiro, Mª José Santos, Ana Filipa Mourão, Maria José Santos, Mónica Eusébio, Ana Lopes, Filipa Oliveira-Ramos, Manuel Salgado, Paula Estanqueiro, José Melo-Gomes, Fernando Martins, José Costa, Carolina Furtado, Ricardo Figueira, Jaime C. Branco, João E. Fonseca, Helena Canhão, Ana F. Mourão, Maria Jose Santos, Andrea Coda, Samuel Cassidy, Kerry West, Gordon Hendry, Debra Grech, Julie Jones, Fiona Hawke, Davinder Singh Grewal, Charlene Foley, Orla Killeen, Emma MacDermott, Douglas Veale, Ursula Fearon, Dilek Konukbay, Ela Tarakci, Nilay Arman, Sezgin Şahin, Jane Munro, Esi Morgan, Meredith Riebschleger, Jennifer Horonjeff, Vibeke Strand, Clifton Bingham, Ma. Theresa M. Collante, Margarita Ganeva, Stefan Stefanov, Albena Telcharova, Dimitrina Mihaylova, Radoslava Saraeva, Reni Tzveova, Radka Kaneva, Adelina Tsakova, Katya Temelkova, GRANT Medical University, Sofia 68/, Maria Mercedes C. Picarelli, Luiz C. Danzmann, Florencia Barbé-Tuana, Lucas K. Grun, Marcus H. Jones, Marijan Frković, Karla Ištuk, Ika Birkić, Saša Sršen, Marija Jelušić, Alan Easton, Rachael Quarmby, Raju Khubchandani, Mercedes Chan, Radoslav Srp, Katerina Kobrova, Dana Nemcova, Jozef Hoza, Michal Uher, Melania Saifridova, Lenka Linkova, Sirirat Charuvanij, Isree Leelayuwattanakul, Thita Pacharapakornpong, Sakda A.-O. Vallipakorn, Butsabong Lerkvaleekul, Soamarat Vilaiyuk, Stefano Lanni, Sergio Davì, Randy Q. Cron, Chiara Passarelli, Elisa Pisaneschi, Antonio Novelli, Claudia Bracaglia, Ivan Caiello, Kathy de Graaf, Florence Guilhot, Walter Ferlin, Grant Schulert, Alexi A. Grom, Robert Nelson, Cristina de Min, Dirk Holzinger, Christoph Kessel, Ndate Fall, Alexei Grom, Wilco de Jager, Raffaele Strippoli, Anna Horne, Stephan Ehl, Sandra Ammann, Kai Lehmberg, Karin Beutel, Dirk Foell, AnnaCarin Horne, Laura Pagani, Graciela Espada, Yi-jin Gao, Susan Shenoi, Sheila Weitzman, Giusi Prencipe, Antonia Pascarella, Walter G. Ferlin, Laurence Chatel, Philippe Jacqmin, Kathy De Graaf, Maria Ballabio, Zoë Johnson, Geneviève Lapeyre, Fabrizio de Benedetti, de Min Cristina, Hiroyuki Wakiguchi, Shunji Hasegawa, Reiji Hirano, Fumiko Okazaki, Tamaki Nakamura, Hidenobu Kaneyasu, Shouichi Ohga, Kazuko Yamazaki, Tomo Nozawa, Taichi Kanetaka, Shuichi Ito, Shumpei Yokota, Kirsty McLellan, Ishbel MacGregor, Neil Martin, Joyce Davidson, Sandra Hansmann, Andreas Eikelberg, Iris Haug, Sabrina Schuller, Susanne M. Benseler, Single Hub and Access point for paediatric Rheumatology in Europe (SHARE), Liliia S. Nazarova, Kseniia V. Danilko, Viktor A. Malievsky, Tatiana V. Viktorova, Angela Mauro, Angela Barnicoat, Jane Hurst, Nathalie Canham, Sandrine Lacassagne, Anastasia Wiener, Boris Hügle, Bernd Denecke, Ivan Costa-Filho, Johannes Peter Haas, Klaus Tenbrock, David Popp, Arjan Boltjes, Frank Rühle, Stefanie Herresthal, Femke van Wijk, Joachim Schultze, Monika Stoll, Luisa Klotz, Thomas Vogl, Johannes Roth, Estefania Quesada-Masachs, Daniel Álvarez de la Sierra, Marina Garcia Prat, Ana M. Marín Sánchez, Ricardo Pujol Borrell, Sara Marsal Barril, Mónica Martínez Gallo, Consuelo Modesto Caballero, Iryna Chyzheuskaya, Lyudmyla M. Byelyaeva, Rostislav M. Filonovich, Helena K. Khrustaleva, Larisa I. Zajtseva, Tamara M. Yuraga, Thomas Giner, Lukas Hackl, Julia Albrecht, Reinhard Würzner, Juergen Brunner, Marta Minute, Fulvio Parentin, Agostino Nocerino, Mette Nørgaard, Mikel Alberdi-Saugstrup, Marek S. Zak, Susan M. Nielsen, Ellen Nordal, Klaus G. Müller, Nordic Study Group of Pediatric Rheumatology (NoSPeR), Mojca Zajc Avramovič, Vita Dolžan, Nataša Toplak, Tadej Avčin, N. Ruperto, D. J. Lovell, C. Wallace, M. Toth, I. Foeldvari, J. Bohnsack, D. Milojevic, C. Rabinovich, D. Kingsbury, K. Marzan, P. Quartier, K. Minden, E. Chalom, G. Horneff, R. M. Kuester, J. Dare, M. Heinrich, H. Kupper, J. Kalabic, H. I. Brunner, on behalf of PRINTO and PRCSG, Ruben Burgos-Vargas, Tamas Constantin, Joke Dehoorne, Valda Stanevica, Katarzyna Kobusinska, Zbigniew Zuber, Richard Mouy, Ingrida Rumba-Rozenfelde, Chantal Job-Deslandre, Ronald Pederson, Jack Bukowski, Tina Hinnershitz, Bonnie Vlahos, Paula Keskitalo, Salla Kangas, Paula Vähäsalo, Raul A. Chavez Valencia, David Martino, Anne-Louise Ponsonby, Rachel Chiaroni-Clarke, Braydon Meyer, Roger C. Allen, Jonathan D. Akikusa, Jeffrey M. Craig, Richard Saffrey, Justine A. Ellis, Carol Wallace, Yosef Uziel, Gary Sterba, Rayfel Schneider, Ricardo Russo, Athimalaipet V. Ramanan, Jana Pachlopnik Schmid, Kim E Nichols, Paivi Miettunen, Toshiyuki Kitoh, Norman T. Ilowite, Jan-Inge Henter, Alexei A Grom, Edward M. Behrens, Tadej Avcin, Maurizio Aricò, Sriharsha Grevich, Peggy Lee, Sarah Ringold, Brian Leroux, Hannah Leahey, Megan Yuasa, Jessica Foster, Jeremy Sokolove, Lauren Lahey, William Robinson, Joshua Newson, Anne Stevens, Stephanie J. W. Shoop, Suzanne M. M. Verstappen, Wendy Thomson, Janet E. McDonagh, CAPS, Timothy Beukelman, Yuki Kimura, Marc Natter, Norm Ilowite, Kelly Mieszkalski, Grendel Burrell, Brian Best, Helen Bristow, Shannon Carr, Anne Dennos, Rachel Kaufmann, Laura Schanberg, for the CARRA Registry Investigators, Gabriele Simonini, Francesca Lancini, Margaux Gerbaux, Phu-Quoc Lê, Laurence Goffin, Valérie Badot, Céline La, Laure Caspers, François Willermain, Alina Ferster, Maria Ceci, Francesco Licciardi, Marco Turco, Francesca Santarelli, Davide Montin, Claudia Toppino, Clotilde Alizzi, Bruno Papia, Beatrice Vergara, Umberto Corpora, Luca Messina, Maria Tsinti, Vasiliko Dermentzoglou, Panagiotis Tziavas, Marija Perica, Lana Tambić Bukovac, Mustafa Çakan, Nuray Aktay Ayaz, Gonca Keskindemirci, Michael Lang, Catherine Laing, Susanne Benseler, Tommy Gerschman, Nadia Luca, Heinrike Schmeling, Anastasia Dropol, Jaymi Taiani, Nicole Johnson, Brian Rusted, Panagiota Nalbanti, Polyxeni Pratsidou, Grigoris Pardalos, Vasiliki Tzimouli, Anna Taparkou, Maria Stavrakidou, Fotios Papachristou, Florence Kanakoudi-Tsakalidou, Peter Bale, Emily Robinson, Jason Palman, Elizabeth Ralph, Kimberly Gilmour, Clare Heard, Lucy R. Wedderburn, Yara Barrense-Dias, Antonarakis Gregory, Dhouib Amira, Scolozzi Paolo, Hanquinet Sylviane, Hofer Michaël, Nataliya Panko, Salah Shokry, Liudmila Rakovska, Sally Pino, Adriana Diaz-Maldonado, Pilar Guarnizo, Sofia Torreggiani, Paolo Cressoni, Umberto Garagiola, Giancarla Di Landro, Giampietro Farronato, Fabrizia Corona, Samantha Bell, Parveen Bhatti, Lee Nelson, Beth A. Mueller, T. A. Simon, A. Baheti, N. Ray, Z. Guo, Anasuya Hazra, Thomas Stock, Ronnie Wang, Charles Mebus, Christine Alvey, Manisha Lamba, Sriram Krishnaswami, Umberto Conte, Min Wang, Daniel Kingsbury, Elena Koskova, Elzbieta Smolewska, Richard K. Vehe, Daniel Lovell, Tomohiro Kubota, Junko Yasumura, Toshitaka Kizawa, Masato Yashiro, Tsuyoshi Yamatou, Yuichi Yamasaki, Syuji Takei, Yoshifumi Kawano, Ulrika Järpemo Nykvist, Bo Magnusson, Rikard Wicksell, Karin Palmblad, Gunnar L. Olsson, Mohammadreza Modaressi, Mohammad-Hassan Moradinejad, Valentina Seraya, Alisa Vitebskaya, Veronica Moshe, Gil Amarilyo, Liora Harel, Phillip J Hashkes, Amir Mendelson, Noa Rabinowicz, Yonit Reis, Zane Dāvidsone, Arina Lazareva, Ruta Šantere, Dace Bērziņa, Valda Staņēviča, Giulia Camilla Varnier, Susan Maillard, Cristina Ferrari, Silvia Zaffarano, Juvenile Dermatomyositis Research Group and European Federation of Immunological Societies, Judith Wienke, Felicitas Bellutti Enders, Lucas L. van den Hoogen, Jorre S. Mertens, Timothy R. Radstake, Henny G. Hotten, Ruth Fritsch, Lucy Wedderburn, Kiran Nistala, Berent Prakken, Annet van Royen-Kerkhof, Mohammad Alhemairi, Mohammed Muzaffer, Pieter Van Dijkhuizen, Claire T. Deakin, Stefania Simou, Maria De Iorio, Qiong Wu, Tania Amin, Lee Dossetter, Juvenile Dermatomyositis Research Group (JDRG), Raquel Campanilho-Marques, Claire Deakin, Clarissa A. Pilkington, on behalf of Juvenile Dermatomyositis Research Group (JDRG), Silvia Rosina, Sirisucha Soponkanaporn, on behalf of the UK Juvenile Dermatomyositis Research Group (JDRG), Zehra S. Arıcı, Gökçen D. Tuğcu, Ezgi D. Batu, Hafize E. Sönmez, Deniz Doğru-Ersöz, Beril Talim, Nural Kiper, Seza Özen, Alexander Solyom, Ezgi Batu, John Mitchell, Ariana Kariminejad, Fatemeh Hadipour, Zahra Hadipour, Marta Torcoletti, Carlo Agostoni, Maja Di Rocco, Pranoot Tanpaiboon, Andrea Superti-Furga, Luisa Bonafé, Nur Arslan, Norberto Guelbert, Karoline Ehlert, Giedre Grigelioniene, Ratna Puri, Edward Schuchman, Pilar Gomez, Tatiana Gonzalez, Ricardo Yepez, Camilo Vargas, GRIP study group, Falcini Fernanda, Gemma Lepri, Alessandra Ferrari, Marco Matucci-Cerinic, Antonella Meini, Gian Marco Moneta, Emiliano Marasco, Rebecca Nicolai, Luisa Bracci-Laudiero, Olga Kopchak, Alexander Mushkin, Alexey Maletin, Catalina Mosquera, Rita A. Amorim, Juliana Molina, Gustavo Moreira, Flávia H. Santos, Melissa Fraga, Livia Keppeke, Vanessa M. Silva, Camila Hirotsu, Sergio Tufik, Maria Teresa Terreri, Vinícius L. Braga, Maria Beatriz Fonseca, Vania Schinzel, Maria Teresa R. Terreri, Liliana Jorge, Liana Guerra, Edson Amaro Junior, Maria Cristina Castiglione, Alessandra Tricarico, Emily Boulter, Andre Schultz, Kevin Murray, Fernanda Falcini, Stefano Stagi, Eleonora Bellucci, Ingrid H. R. Grein, Gecilmara Pileggi, Natália B. F. Pinto, Aline L. de Oliveira, Lyudmila Belyaeva, Rostislav Filonovich, Helena Khrustaleva, Larisa Zajtseva, Jaanika Ilisson, Chris Pruunsild, Olivier Gilliaux, Francis Corazza, Christophe Lelubre, on behalf of PANLAR Pediatric Rheumatology Study Group, Zoilo Morel, Claudia Saad-Magalhães C, Luis Lira, Mabel Ladino, Ruth Eraso, Ivonne Arroyo, Clovis Silva, Carlos Rose, and PANLAR Pediatric Rheumatology Study Group

Subjects
Pediatrics, RJ1-570, Diseases of the musculoskeletal system, RC925-935
Published
2017
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19. Multimessenger Characterization of Markarian 501 during Historically Low X-Ray and γ-Ray Activity

Author

Abe, H., primary, Abe, S., additional, Acciari, V. A., additional, Agudo, I., additional, Aniello, T., additional, Ansoldi, S., additional, Antonelli, L. A., additional, Arbet-Engels, A., additional, Arcaro, C., additional, Artero, M., additional, Asano, K., additional, Baack, D., additional, Babić, A., additional, Baquero, A., additional, de Almeida, U. Barres, additional, Barrio, J. A., additional, Batković, I., additional, Baxter, J., additional, Becerra González, J., additional, Bednarek, W., additional, Bernardini, E., additional, Bernardos, M., additional, Berti, A., additional, Besenrieder, J., additional, Bhattacharyya, W., additional, Bigongiari, C., additional, Biland, A., additional, Blanch, O., additional, Bonnoli, G., additional, Bošnjak, Ž., additional, Burelli, I., additional, Busetto, G., additional, Carosi, R., additional, Carretero-Castrillo, M., additional, Castro-Tirado, A. J., additional, Ceribella, G., additional, Chai, Y., additional, Chilingarian, A., additional, Cikota, S., additional, Colombo, E., additional, Contreras, J. L., additional, Cortina, J., additional, Covino, S., additional, D’Amico, G., additional, D’Elia, V., additional, Da Vela, P., additional, Dazzi, F., additional, De Angelis, A., additional, De Lotto, B., additional, Del Popolo, A., additional, Delfino, M., additional, Delgado, J., additional, Delgado Mendez, C., additional, Depaoli, D., additional, Di Pierro, F., additional, Di Venere, L., additional, Souto Espiñeira, E. Do, additional, Dominis Prester, D., additional, Donini, A., additional, Dorner, D., additional, Doro, M., additional, Elsaesser, D., additional, Emery, G., additional, Escudero, J., additional, Fallah Ramazani, V., additional, Fariña, L., additional, Fattorini, A., additional, Foffano, L., additional, Font, L., additional, Fruck, C., additional, Fukami, S., additional, Fukazawa, Y., additional, García López, R. J., additional, Garczarczyk, M., additional, Gasparyan, S., additional, Gaug, M., additional, Giesbrecht Paiva, J. G., additional, Giglietto, N., additional, Giordano, F., additional, Gliwny, P., additional, Godinović, N., additional, Grau, R., additional, Green, D., additional, Green, J. G., additional, Hadasch, D., additional, Hahn, A., additional, Hassan, T., additional, Heckmann, L., additional, Herrera, J., additional, Hrupec, D., additional, Hütten, M., additional, Imazawa, R., additional, Inada, T., additional, Iotov, R., additional, Ishio, K., additional, Jiménez Martínez, I., additional, Jormanainen, J., additional, Kerszberg, D., additional, Kobayashi, Y., additional, Kubo, H., additional, Kushida, J., additional, Lamastra, A., additional, Lelas, D., additional, Leone, F., additional, Lindfors, E., additional, Linhoff, L., additional, Lombardi, S., additional, Longo, F., additional, López-Coto, R., additional, López-Moya, M., additional, López-Oramas, A., additional, Loporchio, S., additional, Lorini, A., additional, Lyard, E., additional, Machado de Oliveira Fraga, B., additional, Majumdar, P., additional, Makariev, M., additional, Maneva, G., additional, Mang, N., additional, Manganaro, M., additional, Mangano, S., additional, Mannheim, K., additional, Mariotti, M., additional, Martínez, M., additional, Mas-Aguilar, A., additional, Mazin, D., additional, Menchiari, S., additional, Mender, S., additional, Mićanović, S., additional, Miceli, D., additional, Miener, T., additional, Miranda, J. M., additional, Mirzoyan, R., additional, Molina, E., additional, Mondal, H. A., additional, Moralejo, A., additional, Morcuende, D., additional, Moreno, V., additional, Nakamori, T., additional, Nanci, C., additional, Nava, L., additional, Neustroev, V., additional, Nievas Rosillo, M., additional, Nigro, C., additional, Nilsson, K., additional, Nishijima, K., additional, Njoh Ekoume, T., additional, Noda, K., additional, Nozaki, S., additional, Ohtani, Y., additional, Oka, T., additional, Okumura, A., additional, Otero-Santos, J., additional, Paiano, S., additional, Palatiello, M., additional, Paneque, D., additional, Paoletti, R., additional, Paredes, J. M., additional, Pavletić, L., additional, Persic, M., additional, Pihet, M., additional, Pirola, G., additional, Podobnik, F., additional, Moroni, P. G. Prada, additional, Prandini, E., additional, Principe, G., additional, Priyadarshi, C., additional, Rhode, W., additional, Ribó, M., additional, Rico, J., additional, Righi, C., additional, Rugliancich, A., additional, Sahakyan, N., additional, Saito, T., additional, Sakurai, S., additional, Satalecka, K., additional, Saturni, F. G., additional, Schleicher, B., additional, Schmidt, K., additional, Schmuckermaier, F., additional, Schubert, J. L., additional, Schweizer, T., additional, Sitarek, J., additional, Sliusar, V., additional, Sobczynska, D., additional, Spolon, A., additional, Stamerra, A., additional, Strišković, J., additional, Strom, D., additional, Strzys, M., additional, Suda, Y., additional, Surić, T., additional, Tajima, H., additional, Takahashi, M., additional, Takeishi, R., additional, Tavecchio, F., additional, Temnikov, P., additional, Terauchi, K., additional, Terzić, T., additional, Teshima, M., additional, Tosti, L., additional, Truzzi, S., additional, Tutone, A., additional, Ubach, S., additional, van Scherpenberg, J., additional, Acosta, M. Vazquez, additional, Ventura, S., additional, Verguilov, V., additional, Viale, I., additional, Vigorito, C. F., additional, Vitale, V., additional, Vovk, I., additional, Walter, R., additional, Will, M., additional, Wunderlich, C., additional, Yamamoto, T., additional, Zarić, D., additional, Cerruti, M., additional, Acosta-Pulido, J. A., additional, Apolonio, G., additional, Bachev, R., additional, Baloković, M., additional, Benítez, E., additional, Björklund, I., additional, Bozhilov, V., additional, Brown, L. F., additional, Bugg, A., additional, Carbonell, W., additional, Carnerero, M. I., additional, Carosati, D., additional, Casadio, C., additional, Chamani, W., additional, Chen, W. P., additional, Chigladze, R. A., additional, Damljanovic, G., additional, Epps, K., additional, Erkenov, A., additional, Feige, M., additional, Finke, J., additional, Fuentes, A., additional, Gazeas, K., additional, Giroletti, M., additional, Grishina, T. S., additional, Gupta, A. C., additional, Gurwell,, M. A., additional, Heidemann, E., additional, Hiriart, D., additional, Hou, W. J., additional, Hovatta, T., additional, Ibryamov, S., additional, Joner, M. D., additional, Jorstad, S. G., additional, Kania, J., additional, Kiehlmann, S., additional, Kimeridze, G. N., additional, Kopatskaya, E. N., additional, Kopp, M., additional, Korte, M., additional, Kotas, B., additional, Koyama, S., additional, Kramer, J. A., additional, Kunkel, L., additional, Kurtanidze, S. O., additional, Kurtanidze, O. M., additional, Lähteenmäki, A., additional, López, J. M., additional, Larionov, V. M., additional, Larionova, E. G., additional, Larionova, L. V., additional, Leto, C., additional, Lorey, C., additional, Mújica, R., additional, Madejski, G. M., additional, Marchili, N., additional, Marscher, A. P., additional, Minev, M., additional, Modaressi, A., additional, Morozova, D. A., additional, Mufakharov, T., additional, Myserlis, I., additional, Nikiforova, A. A., additional, Nikolashvili, M. G., additional, Ovcharov, E., additional, Perri, M., additional, Raiteri, C. M., additional, Readhead, A. C. S., additional, Reimer, A., additional, Reinhart, D., additional, Righini, S., additional, Rosenlehner, K., additional, Sadun, A. C., additional, Savchenko, S. S., additional, Scherbantin, A., additional, Schneider, L., additional, Schoch, K., additional, Seifert, D., additional, Semkov, E., additional, Sigua, L. A., additional, Singh, C., additional, Sola, P., additional, Sotnikova, Y., additional, Spencer, M., additional, Steineke, R., additional, Stojanovic, M., additional, Strigachev, A., additional, Tornikoski, M., additional, Traianou, E., additional, Tramacere, A., additional, Troitskaya, Yu. V., additional, Troitskiy, I. S., additional, Trump, J. B., additional, Tsai, A., additional, Valcheva, A., additional, Vasilyev, A. A., additional, Verrecchia, F., additional, Villata, M., additional, Vince, O., additional, Vrontaki, K., additional, Weaver, Z. R., additional, Zaharieva, E., additional, and Zottmann, N., additional

Published
2023
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24. The optical behaviour of BL Lacertae at its maximum brightness levels: a blend of geometry and energetics

Author

Raiteri, C M, primary, Villata, M, additional, Jorstad, S G, additional, Marscher, A P, additional, Acosta Pulido, J A, additional, Carosati, D, additional, Chen, W P, additional, Joner, M D, additional, Kurtanidze, S O, additional, Lorey, C, additional, Marchini, A, additional, Matsumoto, K, additional, Mirzaqulov, D O, additional, Savchenko, S S, additional, Strigachev, A, additional, Vince, O, additional, Aceti, P, additional, Apolonio, G, additional, Arena, C, additional, Arkharov, A, additional, Bachev, R, additional, Bader, N, additional, Banfi, M, additional, Bonnoli, G, additional, Borman, G A, additional, Bozhilov, V, additional, Brown, L F, additional, Carbonell, W, additional, Carnerero, M I, additional, Damljanovic, G, additional, Dhiman, V, additional, Ehgamberdiev, S A, additional, Elsaesser, D, additional, Feige, M, additional, Gabellini, D, additional, Galán, D, additional, Galli, G, additional, Gaur, H, additional, Gazeas, K, additional, Grishina, T S, additional, Gupta, A C, additional, Hagen-Thorn, V A, additional, Hallum, M K, additional, Hart, M, additional, Hasuda, K, additional, Heidemann, K, additional, Horst, B, additional, Hou, W-J, additional, Ibryamov, S, additional, Ivanidze, R Z, additional, Jovanovic, M D, additional, Kimeridze, G N, additional, Kishore, S, additional, Klimanov, S, additional, Kopatskaya, E N, additional, Kurtanidze, O M, additional, Kushwaha, P, additional, Lane, D J, additional, Larionova, E G, additional, Leonini, S, additional, Lin, H C, additional, Mannheim, K, additional, Marino, G, additional, Minev, M, additional, Modaressi, A, additional, Morozova, D A, additional, Mortari, F, additional, Nazarov, S V, additional, Nikolashvili, M G, additional, Otero Santos, J, additional, Ovcharov, E, additional, Papini, R, additional, Pinter, V, additional, Privitera, C A, additional, Pursimo, T, additional, Reinhart, D, additional, Roberts, J, additional, Romanov, F D, additional, Rosenlehner, K, additional, Sakamoto, T, additional, Salvaggio, F, additional, Schoch, K, additional, Semkov, E, additional, Seufert, J, additional, Shakhovskoy, D, additional, Sigua, L A, additional, Singh, C, additional, Steineke, R, additional, Stojanovic, M, additional, Tripathi, T, additional, Troitskaya, Y V, additional, Troitskiy, I S, additional, Tsai, A, additional, Valcheva, A, additional, Vasilyev, A A, additional, Vrontaki, K, additional, Weaver, Z R, additional, Wooley, J H F, additional, Zaharieva, E, additional, and Zhovtan, A V, additional

Published
2023
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26. Prevalence and Factors Associated with Stress Urinary Incontinence after Childbirth in Yazd in 2015

Author

M Vakili, M Amoqadiri, M Mohammadi, and M Modaressi

Subjects
Prevalence, Stress Urinary Incontinence, Delivery, Childbirth Complications, Medicine (General), R5-920
Abstract

Introduction: Urinary incontinence is a common occurrence during pregnancy, which disrupts the quality of life of women and also requires a huge cost for treatment, due to the lack of such studies in the city of Yazd, the aim of this study was to determine the prevalence of and the factors associated with stress urinary incontinence after childbirth in Yazd in 2015. Methods: This study was a descriptive- cross sectional study, which included women 4 months after the last delivery referred to Shahid Sadoughi hospital. 500 of them were selected by convenience sampling and their information was obtained through SandviK questionnaire. The data were analyzed via SPSS 16 using chi-square test and T test. Results: Prevalence of stress urinary incontinence after childbirth in this study was 32.4 %. The frequency of urinary incontinence increased in women with one delivery (3.3%), two deliveries (27.6%) and three deliveries (61.1%). The frequency of urinary incontinence after giving birth in a hospital or home was 31.2 % and 76.9 %, respectively, which shows a significant difference (P =0.001). Conclusion: The results of this study show that the frequency of urinary incontinence in women in Yazd is high. With regard to social and medical importance of urinary incontinence, it needs to perform some effective strategies for prevention and treatment of urinary incontinence in the city of Yazd.

Published
2016

27. Prevalence of Gestational Diabetes and Its Risk Factors in Meibod-Yazd 2013-2014

Author

Mahmood Vakili, Mozhgan Modaressi, Razieh Zhabi, and Arezoo Aghakoochak

Subjects
Prevalence, Gestational diabetes, Risk factors, Meibod-Yazd., Public aspects of medicine, RA1-1270
Abstract

Introduction: Diabetes is the most common and important metabolic disorder in pregnancy period. This study aimed to determine the prevalence of gestational diabetes and its risk factors in Meibod County Materials and Methods: This cross-sectional study was carried out using registered data of diabetes screening program for all pregnant women living in Meibod town during the years 2013-2014. In first gynecology visit, FBS test was conducted for 1209 pregnant women who had no past record of diabetes. According to existence or lack of risk factors, participants went through glucose 3-hour tolerance test (OGTT) with 75 grams of glucose. The data were analyzed using SPSS software (Vs. 18) by Chi-squared, t-test, and logistic regression test. Results: Mean age of women with gestational diabetes was 27.8±5.85 while it was 26.1±5.35 for healthy women. There was significant relation between age, body mass index, parity, family record of the diabetes, and history of gestational diabetes (P=0.000). There was no significant relationship between gestational diabetes and history of hypertension, gestational diabetes, stillbirth, spontaneous abortion, child's weight of 4 kg or more at birth, and fetal abnormalities in previous pregnancies. There was also a significant correlation between gestational diabetes and number of risk factors (P

Published
2016

28. Synthesis and characterization of physicochemical and immunological properties of recombinant NS3-G2 dendrimer conjugate

Author

F Javadi, P Rahimi, MH Modaressi, M Shafiee Ardestani, A Bolhassani, MR Aghasadeghi, and SM Sadat

Subjects
adjuvant, dendrimer g2, rns3, hcv, conjugate, Medicine, Science
Abstract

Introduction: An effective vaccine against HCV infection is not available. The non-structural protein 3 (NS3) of the virus as an important immunogenic candidate has been utilized in various modules. Nanostructured polymers have been recently used for efficient vaccine and drug delivery. The aim of the current study was the synthesis of rNS3-G2 conjugate and preliminary evaluation of its immunogenicity. Methods: The dendrimer was synthesized and conjugated with purified recombinant NS3 (rNS3) protein. The physicochemical properties of the conjugate were evaluated by Zeta potential, FT-IR spectra and confirmed by atomic force microscopy (AFM). Immunogenicity of the conjugate was assessed in BALB/c mice. Results: Synthesis and conjugation of dendrimer G2 with the protein were confirmed and immunological assays showed that the conjugated form of the antigen induced higher titer of IgG compared to rNS3 antigen alone. Conclusion: The results showed that the antigenic structure of rNS3 was maintained when conjugated with the biodegradable and biocompatible G2 dendrimers and the immunogenic properties of the antigen were enhanced. Therefore the new formulation may have potential as a vaccine candidate.

Published
2016

29. Hypoxia inducible factor: It’s role in angiogenesis and tumor

Author

Mozhgan Jahani, Mohammad Hosein Modaressi, and Kamran Mansouri

Subjects
angiogenesis, hypoxia, metastasis, tumor, Medicine (General), R5-920
Abstract

Angiogenesis, as the process of new vessel formation from pre-existing vessels is dependent on a delicate equilibrium between endogenous angiogenic and antiangiogenic factors. However, under pathological conditions, this tight regulation becomes lost which can result in the formation of the different diseases such as cancer. Angiogenesis is a complex process that includes many gene products that are produced by different cells. Each of the processes influenced by specific genes that their expression can be regulated by hypoxi inducible factor-1 (HIF-1). Hypoxia, the imbalance between the oxygen in need and the oxygen available, usually occurs in tumors and ischemic cardiovascular diseases. In order to overcome this challenge, tumors regulate and control the expression of genes related to angiogenesis, cell cycle and metabolism using hypoxia-inducible factor 1 (HIF-1). HIF-1 was first recognized as a transcription factor involved in hypoxia-induced erythropoietin expression. As angiogenesis pathway molecules are being described, this factor has been characterized as a key transcription regulator for these molecules. In this review article, after discussing HIF-1 structure and characterization, the role of this important factor in angiogenesis and cancer as a pathological case and finally, the clinical applications has been evaluated. Articles related to the key words of hypoxia, HIF-1 and angiogenesis were searched from valid databases such as Springer Link, google scholar, Pubmed and Sciencedirect. Then, the articles related to the role of hypoxia and HIF-1 in activation of genes that are involved in angiogenesis and cancer were searched and selected for this study. Studies show that, HIF-1 activation of genes including vascular endothelial growth factor (VEGF), angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2), etc., induced angiogenesis in the tumor cells. Furthermore, the activation of genes such as insulin-like growth factor 2 (IGF2), transforming growth factor α (TGF-α) and MAPK and PI3K signaling pathway will also enable the survival and proliferation of tumor cells. HIF-1 by activating genes involved in angiogenesis and also activates signaling pathways associated with cell survival and proliferation plays an important role in the stability and growth of tumors. Therefore, better understanding of molecular mechanisms associated with this factor can be effective in the treatment of cancer.

Published
2016

30. Safety of measles and pertussis-containing vaccines in children with autism spectrum disorders

Author

Ousseny Zerbo, Sharareh Modaressi, Kristin Goddard, Edwin Lewis, Bruce Fireman, Matthew F. Daley, Stephanie A. Irving, Lisa A. Jackson, James G. Donahue, Lei Qian, Darios Getahun, Frank DeStefano, Michael M. McNeil, and Nicola P. Klein

Subjects
Fever, General Veterinary, General Immunology and Microbiology, Autism Spectrum Disorder, Whooping Cough, Measles Vaccine, Public Health, Environmental and Occupational Health, Infant, Seizures, Febrile, Chickenpox Vaccine, Infectious Diseases, Humans, Molecular Medicine, Vaccines, Combined, Child, Measles-Mumps-Rubella Vaccine, Measles
Abstract

To determine whether children aged 4-7 years with a diagnosis of autism spectrum disorders (ASD) were at increased risk of fever, febrile seizures, or emergency department (ED) visits following measles- or pertussis-containing vaccines compared with children without ASD.The study included children born between 1995-2012, aged 4-7 years at vaccination, and members of six healthcare delivery systems within Vaccine Safety Datalink. We conducted self-controlled risk interval analyses comparing rates of outcomes in risk and control intervals within each group defined by ASD status, and then compared outcome rates between children with and without ASD, in risk and control intervals, by estimating difference-in-differences using logistic regressions.The study included 14,947 children with ASD and 1,650,041 children without ASD. After measles- or pertussis-containing vaccination, there were no differences in association between children with and without ASD for fever (ratio of rate ratio for measles-containing vaccine = 1.07, 95% CI 0.58-1.96; for pertussis-containing vaccine = 1.16, 95% CI 0.63-2.15) or ED visits (ratio of rate ratio for measles-containing vaccine = 1.11, 95% CI 0.80-1.54; for pertussis-containing vaccine = 0.87, 95% CI 0.59-1.28). Febrile seizures were rare. Pertussis-containing vaccines were associated with small increased risk of febrile seizures in children without ASD.Children with ASD were not at increased risk for fever or ED visits compared with children without ASD following measles- or pertussis-containing vaccines. These results may provide further reassurance that these vaccines are safe for all children, including those with ASD.

Published
2022
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33. Experimental Assessment of Seismic Pile-Soil Interaction

Author

Simonelli, Armando L., Di Sarno, Luigi, Durante, Maria Giovanna, Sica, Stefania, Bhattacharya, Subhamoy, Dietz, Matt S., Dihoru, Luiza, Taylor, Colin A., Cairo, Roberto, Chidichimo, Andrea, Dente, Giovanni, Modaressi, Arezou, Bom, Luìs A. Todo, Kaynia, Amir M., Anoyatis, George, Mylonakis, George, Ansal, Atilla, Series editor, Ilki, Alper, editor, and Fardis, Michael N., editor

Published
2014
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36. Distress Screening Through Patient-Reported Outcomes Measurement Information System (PROMIS) at an Academic Cancer Center and Network Site: Implementation of a Hybrid Model

Author

Mohana Roy, Shiva Modaressi, Joel W. Neal, Eben L. Rosenthal, Patricia Falconer, Christopher Sharp, Ashley Robinson, Kavitha Ramchandran, Douglas W. Blayney, Kelly Bugos, and Peter S. Galatin

Subjects
medicine.medical_specialty, Patient-Reported Outcomes Measurement Information System, MEDLINE, 03 medical and health sciences, 0302 clinical medicine, Neoplasms, Surveys and Questionnaires, medicine, Humans, Mass Screening, Center (algebra and category theory), Patient Reported Outcome Measures, 030212 general & internal medicine, Early Detection of Cancer, Oncology (nursing), business.industry, Health Policy, Cancer, medicine.disease, Distress, Oncology, 030220 oncology & carcinogenesis, Family medicine, Distress screening, business, Hybrid model, Information Systems
Abstract

PURPOSE: Cancer care guidelines recommend regular distress screening of patients, with approximately one in three patients with cancer experiencing significant distress. However, the implementation of such programs is variable and inconsistent. We sought to assess the feasibility of implementing a hybrid electronic and paper screening tool for distress in all patients coming to a large academic cancer center and an associated integrated network site. METHODS: Patients at an academic cancer center (Stanford Cancer Center) and its associated integrated network site received either an electronic or on-paper modified Patient-Reported Outcomes Measurement Information System-Global Health questionnaire, to assess overall health and distress. We used the Reach, Effectiveness, Adoption, Implementation, and Maintenance implementation framework to test and report on the feasibility of using this questionnaire. Iterative workflow changes were made to implement the questionnaire throughout the healthcare system, including processes to integrate with existing electronic health records. RESULTS: From June 2015 to December 2017, 53,954 questionnaires representing 26,242 patients were collected. Approximately 30% of the questionnaires were completed before the visit on an electronic patient portal. The number of patients meeting the positive screen threshold remained around 40% throughout the study period. Following assessment, there were 3,763 referrals to cancer supportive services. Of note, those with a positive screen were more likely to have a referral to supportive care (odds ratio, 6.4; 95% CI, 5.8 to 6.9; P < .0001). CONCLUSION: The hybrid electronic and on-paper use of a commonly available patient-reported outcome tool, Patient-Reported Outcomes Measurement Information System-Global Health, as a large-scale distress screening method, is feasible at a large integrated cancer center.

Published
2021
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37. The optical behaviour of BL Lacertae at its maximum brightness levels: a blend of geometry and energetics

Author

C M Raiteri, M Villata, S G Jorstad, A P Marscher, J A Acosta Pulido, D Carosati, W P Chen, M D Joner, S O Kurtanidze, C Lorey, A Marchini, K Matsumoto, D O Mirzaqulov, S S Savchenko, A Strigachev, O Vince, P Aceti, G Apolonio, C Arena, A Arkharov, R Bachev, N Bader, M Banfi, G Bonnoli, G A Borman, V Bozhilov, L F Brown, W Carbonell, M I Carnerero, G Damljanovic, V Dhiman, S A Ehgamberdiev, D Elsaesser, M Feige, D Gabellini, D Galán, G Galli, H Gaur, K Gazeas, T S Grishina, A C Gupta, V A Hagen-Thorn, M K Hallum, M Hart, K Hasuda, K Heidemann, B Horst, W-J Hou, S Ibryamov, R Z Ivanidze, M D Jovanovic, G N Kimeridze, S Kishore, S Klimanov, E N Kopatskaya, O M Kurtanidze, P Kushwaha, D J Lane, E G Larionova, S Leonini, H C Lin, K Mannheim, G Marino, M Minev, A Modaressi, D A Morozova, F Mortari, S V Nazarov, M G Nikolashvili, J Otero Santos, E Ovcharov, R Papini, V Pinter, C A Privitera, T Pursimo, D Reinhart, J Roberts, F D Romanov, K Rosenlehner, T Sakamoto, F Salvaggio, K Schoch, E Semkov, J Seufert, D Shakhovskoy, L A Sigua, C Singh, R Steineke, M Stojanovic, T Tripathi, Y V Troitskaya, I S Troitskiy, A Tsai, A Valcheva, A A Vasilyev, K Vrontaki, Z R Weaver, J H F Wooley, E Zaharieva, and A V Zhovtan

Subjects
High Energy Astrophysical Phenomena (astro-ph.HE), Space and Planetary Science, FOS: Physical sciences, Astronomy and Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract

In 2021 BL Lacertae underwent an extraordinary activity phase, which was intensively followed by the Whole Earth Blazar Telescope (WEBT) Collaboration. We present the WEBT optical data in the BVRI bands acquired at 36 observatories around the world. In mid 2021 the source showed its historical maximum, with R = 11.14. The light curves display many episodes of intraday variability, whose amplitude increases with source brightness, in agreement with a geometrical interpretation of the long-term flux behaviour. This is also supported by the long-term spectral variability, with an almost achromatic trend with brightness. In contrast, short-term variations are found to be strongly chromatic and are ascribed to energetic processes in the jet. We also analyse the optical polarimetric behaviour, finding evidence of a strong correlation between the intrinsic fast variations in flux density and those in polarisation degree, with a time delay of about 13 h. This suggests a common physical origin. The overall behaviour of the source can be interpreted as the result of two mechanisms: variability on time scales greater than several days is likely produced by orientation effects, while either shock waves propagating in the jet, or magnetic reconnection, possibly induced by kink instabilities in the jet, can explain variability on shorter time scales. The latter scenario could also account for the appearance of quasi-periodic oscillations, with periods from a few days to a few hours, during outbursts, when the jet is more closely aligned with our line of sight and the time scales are shortened by relativistic effects., Comment: 15 pages, 16 figures, submitted to MNRAS

Published
2023
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38. Multimessenger Characterization of Markarian 501 during Historically Low X-Ray and $γ$-Ray Activity

Author

Abe, Abe, H., Acciari, S., Agudo, V. A., Aniello, I., Ansoldi, T., Antonelli, S., Arbet-Engels, L. A., Arcaro, A., Artero, C., Asano, M., Baack, K., Babić, D., Baquero, A., de Almeida, A., Barres, Barrio, U., Batković, J. A., Baxter, I., Becerra González, J., Bednarek, J., Bernardini, W., Bernardos, E., Berti, M., Besenrieder, A., Bhattacharyya, J., Bigongiari, W., Biland, C., Blanch, A., Bonnoli, O., Bošnjak, G., Burelli, Ž., Busetto, I., Carosi, G., Carretero-Castrillo, R., Castro-Tirado, M., Ceribella, A. J., Chai, G., Chilingarian, Y., Cikota, A., Colombo, S., Contreras, E., Cortina, J. L., Covino, J., D’Amico, S., D’Elia, G., Da Vela, V., Dazzi, P., De Angelis, F., De Lotto, A., Del Popolo, B., Delfino, A., Delgado, M., Delgado Mendez, J., Depaoli, C., Di Pierro, D., Di Venere, F., Souto Espiñeira, L., Dominis Prester, E., Donini, D., Dorner, A., Doro, D., Elsaesser, M., Emery, D., Escudero, G., Fallah Ramazani, J., Fariña, V., Fattorini, L., Foffano, A., Font, L., Fruck, L., Fukami, C., Fukazawa, S., García López, Y., Garczarczyk, R. J., Gasparyan, M., Gaug, S., Giesbrecht Paiva, M., Giglietto, J. G., Giordano, N., Gliwny, F., Godinović, P., Grau, N., Green, R., Green, D., Hadasch, J. G., Hahn, D., Hassan, A., Heckmann, T., Herrera, L., Hrupec, J., Hütten, D., Imazawa, M., Inada, R., Iotov, T., Ishio, R., Jiménez Martínez, K., Jormanainen, I., Kerszberg, J., Kobayashi, D., Kubo, Y., Kushida, H., Lamastra, J., Lelas, A., Leone, D., Lindfors, F., Linhoff, E., Lombardi, L., Longo, S., López-Coto, F., López-Moya, R., López-Oramas, M., Loporchio, A., Lorini, S., Lyard, A., Machado de Oliveira Fraga, E., Majumdar, B., Makariev, P., Maneva, M., Mang, G., Manganaro, N., Mangano, M., Mannheim, S., Mariotti, K., Martínez, M., Mas-Aguilar, M., Mazin, A., Menchiari, D., Mender, S., Mićanović, S., Miceli, S., Miener, D., Miranda, T., Mirzoyan, J. M., Molina, R., Mondal, E., Moralejo, H. A., Morcuende, A., Moreno, D., Nakamori, V., Nanci, T., Nava, C., Neustroev, L., Nievas Rosillo, V., Nigro, M., Nilsson, C., Nishijima, K., Njoh Ekoume, K., Noda, T., Nozaki, K., Ohtani, S., Oka, Y., Okumura, T., Otero-Santos, A., Paiano, J., Palatiello, S., Paneque, M., Paoletti, D., Paredes, R., Pavletić, J. M., Persic, L., Pihet, M., Pirola, M., Podobnik, G., Moroni, F., Prada, Prandini, P. G., Principe, E., Priyadarshi, G., Rhode, C., Ribó, W., Rico, M., Righi, J., Rugliancich, C., Sahakyan, A., Saito, N., Sakurai, T., Satalecka, S., Saturni, K., Schleicher, F. G., Schmidt, B., Schmuckermaier, K., Schubert, F., Schweizer, J. L., Sitarek, T., Sliusar, J., Sobczynska, V., Spolon, D., Stamerra, A., Strišković, A., Strom, J., Strzys, D., Suda, M., Surić, Y., Tajima, T., Takahashi, H., Takeishi, M., Tavecchio, R., Temnikov, F., Terauchi, P., Terzić, K., Teshima, T., Tosti, M., Truzzi, L., Tutone, S., Ubach, A., van Scherpenberg, S., Acosta, J., Vazquez, Ventura, M., Verguilov, S., Viale, V., Vigorito, I., Vitale, C. F., Vovk, V., Walter, I., Will, R., Wunderlich, M., Yamamoto, C., Zarić, T., Cerruti, D., Acosta-Pulido, M., Apolonio, J. A., Bachev, G., Baloković, R., Benítez, M., Björklund, E., Bozhilov, I., Brown, V., Bugg, L. F., Carbonell, A., Carnerero, W., Carosati, M. I., Casadio, D., Chamani, C., Chen, W., Chigladze, W. P., Damljanovic, R. A., Epps, G., Erkenov, K., Feige, A., Finke, M., Fuentes, J., Gazeas, A., Giroletti, K., Grishina, M., Gupta, T. S., Heidemann, A. C., Gurwell, M. A., Hiriart, E., Hou, D., Hovatta, W. J., Ibryamov, T., Joner, S., Jorstad, M. D., Kania, S. G., Kiehlmann, J., Kimeridze, S., Kopatskaya, G. N., Kopp, E. N., Korte, M., Kotas, M., Koyama, B., Kramer, S., Kunkel, J. A., Kurtanidze, L., Kurtanidze, S. O., Lähteenmäki, O. M., López, A., Larionov, J. M., Larionova, V. M., Larionova, E. G., Leto, L. V., Lorey, C., Mújica, C., Madejski, R., Marchili, G. M., Marscher, N., Minev, A. P., Modaressi, M., Morozova, A., Mufakharov, D. A., Myserlis, T., Nikiforova, I., Nikolashvili, A. A., Ovcharov, M. G., Perri, E., Raiteri, M., Readhead, C. M., Reimer, A. C. S., Reinhart, A., Righini, D., Rosenlehner, S., Sadun, K., Savchenko, A. C., Scherbantin, S. S., Schneider, A., Schoch, L., Seifert, K., Semkov, D., Sigua, E., Singh, L. A., Sola, C., Sotnikova, P., Spencer, Y., Steineke, M., Stojanovic, R., Strigachev, M., Tornikoski, A., Traianou, M., Tramacere, E., Troitskaya, A., Troitskiy, Yu. V., Trump, I. S., Tsai, J. B., Valcheva, A., Vasilyev, A., Verrecchia, A. A., Villata, F., Vince, M., Vrontaki, O., Weaver, K., Zaharieva, Z. R., and Zottmann, E.

Subjects
ddc:520
Abstract

The astrophysical journal / Supplement series 266(2), 37 (2023). doi:10.3847/1538-4365/acc181, We study the broadband emission of Mrk 501 using multiwavelength observations from 2017 to 2020 performed with a multitude of instruments, involving, among others, MAGIC, Fermi's Large Area Telescope (LAT), NuSTAR, Swift, GASP-WEBT, and the Owens Valley Radio Observatory. Mrk 501 showed an extremely low broadband activity, which may help to unravel its baseline emission. Nonetheless, significant flux variations are detected at all wave bands, with the highest occurring at X-rays and very-high-energy (VHE) $γ$-rays. A significant correlation (>3σ) between X-rays and VHE $γ$-rays is measured, supporting leptonic scenarios to explain the variable parts of the emission, also during low activity. This is further supported when we extend our data from 2008 to 2020, and identify, for the first time, significant correlations between the Swift X-Ray Telescope and Fermi-LAT. We additionally find correlations between high-energy γ-rays and radio, with the radio lagging by more than 100 days, placing the γ-ray emission zone upstream of the radio-bright regions in the jet. Furthermore, Mrk 501 showed a historically low activity in X-rays and VHE $γ$-rays from mid-2017 to mid-2019 with a stable VHE flux (>0.2 TeV) of 5% the emission of the Crab Nebula. The broadband spectral energy distribution (SED) of this 2 $γ$r long low state, the potential baseline emission of Mrk 501, can be characterized with one-zone leptonic models, and with (lepto)-hadronic models fulfilling neutrino flux constraints from IceCube. We explore the time evolution of the SED toward the low state, revealing that the stable baseline emission may be ascribed to a standing shock, and the variable emission to an additional expanding or traveling shock., Published by Institute of Physics Publ., London

Published
2023
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48. Safety of Live-Attenuated Vaccines in Children Exposed to Biologic Response Modifiers in Utero

Author

Zerbo, Ousseny, primary, Modaressi, Sharareh, additional, Goddard, Kristin, additional, Lewis, Edwin, additional, Getahun, Darios, additional, Palmsten, Kristin K., additional, Fuller, Candace C., additional, Crane, Bradley, additional, Donahue, James G., additional, Daley, Matthew F., additional, Jackson, Lisa A., additional, Wodi, A. Patricia, additional, McNeil, Michael M., additional, and Klein, Nicola P., additional

Published
2022
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50. Investigating the Factors Affecting Sleep Problems among High-School Students in Yazd City, Iran

Author

Mahmood Vakili, Mozhgan Modaressi, Maasomah Rezvani, and Arezoo Aghakoochak

Subjects
Sleep disturbances, Adolescents, Iran, Medicine
Abstract

Background and Objective: Poor sleep, poor quality of sleep and sleepiness are among the common problems as-sociated with learning, memory and educational performance in children and adolescents. Considering the lack of pre-vious literature in this field, especially in the city of Yazd, Iran, a number of high-school students of the city participat-ed in a study to assess sleep problems and influencing factors. Materials and Methods: In this cross-sectional study, 740 high-school students in Yazd were selected using multi-stage cluster random sampling method. The data were collected using Pittsburg Sleep Quality Index (PSQI), reliability and validity of which had been proved (with Cronbach’s alpha of 0.8). After encoding questionnaires, correlation and chi-square tests were used to evaluate the impact of corresponding factors on sleep quality via SPSS software. Results: Of 740 students, 39% had sleep disturbances that had significant relationship with variables of gender, field of study, father's occupation, and father's education. Mean PSQI score did not have significant relationship with varia-bles of mother's education, body mass index (BMI), students’ birth, and mother's job. Furthermore, 16.7% of students were unsatisfied with their sleep pattern, while 3.5%, 58.7%, and 21.1% were very unsatisfied, satisfied, and very satis-fied, respectively. Conclusion: Teenagers’ sleep may be affected by different factors such as sex, field of study, father's occupation, and father's education. Change in environmental and family condition could improve sleep disturbances, educational, and occupational performance.

Published
2016

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