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6. Beneficial Effects of Ursodeoxycholic Acid on Metabolic Parameters and Oxidative Stress in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind, Placebo-Controlled Clinical Study

Author

Lakić, Biljana, primary, Škrbić, Ranko, additional, Uletilović, Snežana, additional, Mandić-Kovačević, Nebojša, additional, Grabež, Milkica, additional, Šarić, Mirna Popović, additional, Stojiljković, Miloš P., additional, Soldatović, Ivan, additional, Janjetović, Zorica, additional, Stokanović, Anastasija, additional, Stojaković, Nataša, additional, and Mikov, Momir, additional

Published
2024
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7. Ursodeoxycholic and chenodeoxycholic bile acids attenuate systemic and liver inflammation induced by lipopolysaccharide in rats

Author

Milivojac, Tatjana, primary, Grabež, Milkica, additional, Krivokuća, Aleksandra, additional, Maličević, Uglješa, additional, Bojić, Milica Gajić, additional, Đukanović, Đorđe, additional, Uletilović, Snežana, additional, Mandić-Kovačević, Nebojša, additional, Cvjetković, Tanja, additional, Barudžija, Maja, additional, Vojinović, Nataša, additional, Šmitran, Aleksandra, additional, Amidžić, Ljiljana, additional, Stojiljković, Miloš P, additional, Čolić, Miodrag, additional, Mikov, Momir, additional, and Škrbić, Ranko, additional

Published
2024
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8. ANNUAL ANALYSIS OF PARASITIC INFECTIONS IN BULGARIA IN 2022

Author

Harizanov, Rumen, primary, Videnova, Mihaela, additional, Mikov, Ognyan, additional, Kaftandjiev, Iskren, additional, Ivanova, Aleksandra, additional, Kaneva, Eleonora, additional, Borisova, Raina, additional, Tsvetkova, Nina, additional, Rainova, Iskra, additional, and Yakimova, Violeta, additional

Published
2024
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10. Novel polysaccharides–bile acid–cyclodextrin gel systems and effects on cellular viability and bioenergetic parameters

Author

Kovacevic, Bozica, primary, Ionescu, Corina Mihaela, additional, Jones, Melissa, additional, Wagle, Susbin Raj, additional, Foster, Thomas, additional, Lewkowicz, Michael, additional, Wong, Elaine YM, additional, Ðanić, Maja, additional, Mikov, Momir, additional, Mooranian, Armin, additional, and Al-Salami, Hani, additional

Published
2024
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21. Beneficial Effects of Ursodeoxycholic Acid on Metabolic Parameters and Oxidative Stress in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind, Placebo-Controlled Clinical Study

Author

Biljana Lakić, Ranko Škrbić, Snežana Uletilović, Nebojša Mandić-Kovačević, Milkica Grabež, Mirna Popović Šarić, Miloš P. Stojiljković, Ivan Soldatović, Zorica Janjetović, Anastasija Stokanović, Nataša Stojaković, and Momir Mikov

Subjects
Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Background. Oxidative stress and inflammation are closely related pathophysiological processes, both occurring in type 2 diabetes mellitus (T2DM). In addition to the standard treatment of T2DM, a potential strategy has been focused on the use of bile acids (BAs) as an additional treatment. Ursodeoxycholic acid (UDCA), as the first BA used in humans, improves glucose and lipid metabolism and attenuates oxidative stress. The aim of this study was to evaluate the potential metabolic, anti-inflammatory, and antioxidative effects of UDCA in patients with T2DM. Methods. This prospective, double-blind, placebo-controlled clinical study included 60 patients with T2DM, randomly allocated to receive UDCA or placebo. Subjects were treated with 500 mg tablets of UDCA or placebo administered three times per day (total dose of 1500 mg/day) for eight weeks. Two study visits, at the beginning (F0) and at the end (F1) of the study, included the interview, anthropometric and clinical measurements, and biochemical analyses. Results. UDCA treatment showed a significant reduction in body mass index (p=0.024) and in diastolic blood pressure (p=0.033), compared to placebo. In addition, there was a statistically significant difference in waist circumference in the UDCA group before and after treatment (p

Published
2024
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22. ANNUAL ANALYSIS OF PARASITIC INFECTIONS IN BULGARIA IN 2022

Author

Rumen Harizanov, Mihaela Videnova, Ognyan Mikov, Iskren Kaftandjiev, Aleksandra Ivanova, Eleonora Kaneva, Raina Borisova, Nina Tsvetkova, Iskra Rainova, and Violeta Yakimova

Subjects
parasitic diseases, incidence, prevalence, zoonoses, Infectious and parasitic diseases, RC109-216
Abstract

INTRODUCTION: Infections caused by parasites still represent an important global health problem. Although parasitic infections are responsible for significant morbidity and mortality in developing countries, they are also prevalent in developed countries. This study aims to establish the dynamics of the parasitic infections registered in the country (local and imported) and to analyze the situation, based on data from the previous years. METHODS: We used the annual reports of regional health inspectorates, diagnostic laboratories, medical universities, and data from the National center of infectious and parasitic diseases about all individuals infected with parasitic diseases in the country. RESULTS: A total of 635,522 persons were examined in 2022, of whom 1.82% were diagnosed with various parasitic infections. In the local helminthic zoonoses such as echinococcosis and trichinellosis, a significant decrease in morbidity was observed,1.3%₀₀₀ (n = 89) for cystic echinococcosis and 0.16%₀₀₀ (n = 9) for trichinellosis. For soil-transmitted helminthiases (ascariasis and trichuriasis), the incidence was 6.7%₀₀₀ and 0.5%₀₀₀, respectively. Data on enterobiasis does not show any particular dynamics in 2022 either. The registered prevalence for the country was 1.48%, and for children from various childcare facilities - 2.45%. During the year, seven cases of vector-borne parasitic diseases were registered in the country: imported malaria was diagnosed in 5 patients (4 Bulgarian citizens and one foreigner), and autochthonous visceral leishmaniasis - in two persons. CONCLUSIONS: The analysis shows that, in spite of a trend of declining morbidityfor some socially significant protozoan and helminth infections, human parasitic diseases still represent a significant problem with social and medical consequences for the population of our country. Therefore, it is necessary to preserve and strengthen the surveillance and control network by including new personnel in the medical parasitology structures.

Published
2024
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25. Factors Affecting Balance Performance in Adolescents

Author

Milena Kovačević, Rastislava Krasnik, Aleksandra Mikov, Darko Mikić, Jelena Zvekić-Svorcan, Dragana Vukliš, Dajana Dedić Novaković, and Marina Đelić

Subjects
balance, adolescence, anthopometry, physical activity, Pediatrics, RJ1-570
Abstract

(1) Background: The influence of different factors on balance in adolescence is assessed by conducting functional balance tests that examine its different components. (2) Materials and methods: The study sample comprised 110 healthy adolescents of both sexes, aged 12–18 years. Single Leg Stance with Eyes Open (SLS-EO) and Eyes Closed (SLS-EC) tests were conducted to evaluate static balance, whereas the Functional Reach Test (FRT) and Lateral Reach Test (LRT) were performed to establish functional stability limits. The influence of sex, age, demographic factors, anthropometric characteristics, participation in sports activities, and trunk extensor muscle endurance (Biering–Sorensen test) on balance performance was determined through correlational and univariate linear regression analyses. (3) Results: Older age (Beta [β] = 0.247; 95% CI [0.75, 5.20]; p < 0.01) and better trunk extensor muscle endurance (β = 0.224; 95% CI [0.015, 0.13]; p < 0.05) were significant predictors of the SLS-EO results, while younger age (β = −0.219; 95% CI [−1.32, −0.11]; p < 0.05) and higher muscle percentage (β = 0.237; 95% CI [0.06, 0.48]; p < 0.05) emerged as significant predictors of LRT performance, and greater bone mass was a significant predictor of FRT results (β = 0.444; 95% CI [3.62, 8.17]; p < 0.01). However, none of the independent variables was a statistically significant predictor of the SLS-EC results. (4) Conclusions: The current study found that age, trunk extensor muscle endurance, muscle percentage, and bone mass are significant predictors of different balance components, suggesting that balance is task-specific.

Published
2024
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27. Pharmaceutical characterization of probucol bile acid–lithocholic acid nanoparticles to prevent chronic hearing related and similar cellular oxidative stress pathologies

Author

Wagle, Susbin R, primary, Ionescu, Corina M, additional, Kovacevic, Bozica, additional, Jones, Melissa, additional, Foster, Thomas, additional, Lim, Patrick, additional, Lewkowicz, Michael, additional, Ðanić, Maja, additional, Mikov, Momir, additional, Mooranian, Armin, additional, and Al-Salami, Hani, additional

Published
2023
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29. Low-dose nano-gel incorporated with bile acids enhanced pharmacology of surgical implants

Author

Mooranian, Armin, primary, Ionescu, Corina Mihaela, additional, Wagle, Susbin Raj, additional, Kovacevic, Bozica, additional, Walker, Daniel, additional, Jones, Melissa, additional, Chester, Jacqueline, additional, Johnston, Edan, additional, Mikov, Momir, additional, Stankov, Karmen, additional, Elnashar, Magdy, additional, and Al-Salami, Hani, additional

Published
2023
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30. Impact of Novel Teflon-DCA Nanogel Matrix on Cellular Bioactivity

Author

Kovacevic, Bozica, primary, Ionescu, Corina Mihaela, additional, Wagle, Susbin Raj, additional, Jones, Melissa, additional, Lewkowicz, Michael, additional, Wong, Elaine Y.M., additional, Đanić, Maja, additional, Mikov, Momir, additional, Mooranian, Armin, additional, and Al-Salami, Hani, additional

Published
2023
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32. PREVALENCE OF PARASITIC PATHOLOGY AMONG HUMANS IN BULGARIA

Author

Harizanov, Rumen, primary, Rainova, Iskra, additional, Tsvetkova, Nina, additional, Kaftandjiev, Iskren, additional, Borisova, Raina, additional, Videnova, Mihaela, additional, Kaneva, Eleonora, additional, Mikov, Ognyan, additional, Ivanova, Aleksandra, additional, and Yakimova, Violeta, additional

Published
2023
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34. Novel hydrogel comprising non-ionic copolymer with various concentrations of pharmacologically active bile acids for cellular injectable gel

Author

Kovacevic, Bozica, primary, Wagle, Susbin Raj, additional, Ionescu, Corina Mihaela, additional, Jones, Melissa, additional, Lewkowicz, Michael, additional, Wong, Elaine YM, additional, Kojic, Sanja, additional, Stojanovic, Goran, additional, Đanić, Maja, additional, Mikov, Momir, additional, Mooranian, Armin, additional, and Al-Salami, Hani, additional

Published
2023
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