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1. Combination of white matter hyperintensities and Aβ burden is related to cognitive composites domain scores in subjective cognitive decline: the FACEHBI cohort

Author

G. Ortega, A. Espinosa, M. Alegret, GC. Monté-Rubio, O. Sotolongo-Grau, A. Sanabria, JP. Tartari, O. Rodríguez-Gómez, M. Marquié, A. Vivas, M. Gómez-Chiari, E. Alarcón-Martín, A. Pérez-Cordón, N. Roberto, I. Hernández, M. Rosende-Roca, L. Vargas, A. Mauleón, C. Abdelnour, E. Esteban De Antonio, R. López-Cuevas, S. Alonso-Lana, S. Moreno-Grau, I. de Rojas, A. Orellana, L. Montrreal, L. Tárraga, A. Ruiz, M. Boada, S. Valero, and FACEHBI group

Subjects
Amyloid-beta (Aß), Apolipoprotein E, Cognitive composites domain scores, FBB-PET, Magnetic resonance imaging, Subjective cognitive decline, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Background To explore whether the combination of white matter hyperintensities (WMHs) and amyloid-beta (Aβ) deposition is associated with worse cognitive performance on cognitive composites (CCs) domain scores in individuals with subjective cognitive decline (SCD). Methods Two hundred participants from the FACEHBI cohort underwent structural magnetic resonance imaging (MRI), 18F-florbetaben positron emission tomography (FBB-PET), and neuropsychological assessment. WMHs were addressed through the Fazekas scale, the Age-Related White Matter Changes (ARWMC) scale, and the FreeSurfer pipeline. Eight CCs domain scores were created using the principal component analysis (PCA). Age, sex, education, and apolipoprotein E (APOE) were used as adjusting variables. Results Adjusted multiple linear regression models showed that FreeSurfer (B − .245; 95% CI − .1.676, − .393, p = .016) and β burden (SUVR) (B − .180; 95% CI − 2.140, − .292; p = .070) were associated with face–name associative memory CCs domain score, although the latest one was not statistically significant after correction for multiple testing (p = .070). There was non-significant interaction of these two factors on this same CCs domain score (p = .54). However, its cumulative effects on face–name associative performance indicated that those individuals with either higher WMH load or higher Aβ burden showed the worst performance on the face–name associative memory CCs domain score. Conclusions Our results suggest that increased WMH load and increased Aβ are independently associated with poorer episodic memory performance in SCD individuals, indicating a cumulative effect of the combination of these two pathological conditions in promoting lower cognitive performance, an aspect that could help in terms of treatment and prevention.

Published
2021
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2. Colloidoscope: Detecting Dense Colloids in 3d with Deep Learning

Author

Kawafi, Abdelwahab, Kürten, Lars, Ortlieb, Levke, Yang, Yushi, Amieva, Abraham Mauleon, Hallett, James E., and Royall, C. Patrick

Subjects
Condensed Matter - Soft Condensed Matter, Condensed Matter - Materials Science, Condensed Matter - Statistical Mechanics
Abstract

Colloidoscope is a deep learning pipeline employing a 3D residual Unet architecture, designed to enhance the tracking of dense colloidal suspensions through confocal microscopy. This methodology uses a simulated training dataset that reflects a wide array of real-world imaging conditions, specifically targeting high colloid volume fraction and low-contrast scenarios where traditional detection methods struggle. Central to our approach is the use of experimental signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and point-spread-functions (PSFs) to accurately quantify and simulate the experimental data. Our findings reveal that Colloidoscope achieves superior recall in particle detection (finds more particles) compared to conventional heuristic methods. Simultaneously, high precision is maintained (high fraction of true positives.) The model demonstrates a notable robustness to photobleached samples, thereby prolonging the imaging time and number of frames than may be acquired. Furthermore, Colloidoscope maintains small scale resolution sufficient to classify local structural motifs. Evaluated across both simulated and experimental datasets, Colloidoscope brings the advancements in computer vision offered by deep learning to particle tracking at high volume fractions. We offer a promising tool for researchers in the soft matter community, this model is deployed and available to use pretrained: https://github.com/wahabk/colloidoscope., Comment: 20 pages

Published
2024

4. Correlations between plasma and PET beta-amyloid levels in individuals with subjective cognitive decline: the Fundació ACE Healthy Brain Initiative (FACEHBI)

Author

Itziar de Rojas, J. Romero, O. Rodríguez-Gomez, P. Pesini, A. Sanabria, A. Pérez-Cordon, C. Abdelnour, I. Hernández, M. Rosende-Roca, A. Mauleón, L. Vargas, M. Alegret, A. Espinosa, G. Ortega, S. Gil, M. Guitart, A. Gailhajanet, M. A. Santos-Santos, Sonia Moreno-Grau, O. Sotolongo-Grau, S. Ruiz, L. Montrreal, E. Martín, E. Pelejà, F. Lomeña, F. Campos, A. Vivas, M. Gómez-Chiari, M. A. Tejero, J. Giménez, V. Pérez-Grijalba, G. M. Marquié, G. Monté-Rubio, S. Valero, A. Orellana, L. Tárraga, M. Sarasa, A. Ruiz, M. Boada, and on behalf of the FACEHBI study

Subjects
Subjective cognitive decline, Preclinical AD, Alzheimer’s disease, Amyloid β, Plasma biomarker, TP42/40, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Background Peripheral biomarkers that identify individuals at risk of developing Alzheimer’s disease (AD) or predicting high amyloid beta (Aβ) brain burden would be highly valuable. To facilitate clinical trials of disease-modifying therapies, plasma concentrations of Aβ species are good candidates for peripheral AD biomarkers, but studies to date have generated conflicting results. Methods The Fundació ACE Healthy Brain Initiative (FACEHBI) study uses a convenience sample of 200 individuals diagnosed with subjective cognitive decline (SCD) at the Fundació ACE (Barcelona, Spain) who underwent amyloid florbetaben(18F) (FBB) positron emission tomography (PET) brain imaging. Baseline plasma samples from FACEHBI subjects (aged 65.9 ± 7.2 years) were analyzed using the ABtest (Araclon Biotech). This test directly determines the free plasma (FP) and total plasma (TP) levels of Aβ40 and Aβ42 peptides. The association between Aβ40 and Aβ42 plasma levels and FBB-PET global standardized uptake value ratio (SUVR) was determined using correlations and linear regression-based methods. The effect of the APOE genotype on plasma Aβ levels and FBB-PET was also assessed. Finally, various models including different combinations of demographics, genetics, and Aβ plasma levels were constructed using logistic regression and area under the receiver operating characteristic curve (AUROC) analyses to evaluate their ability for discriminating which subjects presented brain amyloidosis. Results FBB-PET global SUVR correlated weakly but significantly with Aβ42/40 plasma ratios. For TP42/40, this observation persisted after controlling for age and APOE ε4 allele carrier status (R 2 = 0.193, p = 1.01E-09). The ROC curve demonstrated that plasma Aβ measurements are not superior to APOE and age in combination in predicting brain amyloidosis. It is noteworthy that using a simple preselection tool (the TP42/40 ratio with an empirical cut-off value of 0.08) optimizes the sensitivity and reduces the number of individuals subjected to Aβ FBB-PET scanners to 52.8%. No significant dependency was observed between APOE genotype and plasma Aβ measurements (p value for interaction = 0.105). Conclusion Brain and plasma Aβ levels are partially correlated in individuals diagnosed with SCD. Aβ plasma measurements, particularly the TP42/40 ratio, could generate a new recruitment strategy independent of the APOE genotype that would improve identification of SCD subjects with brain amyloidosis and reduce the rate of screening failures in preclinical AD studies. Independent replication of these findings is warranted.

Published
2018
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5. Complex flow profiles in microscopic active crystals

Author

Mauleon-Amieva, Abraham, Liverpool, Tanniemola B., Williams, Ian, Souslov, Anton, and Royall, C. Patrick

Subjects
Condensed Matter - Soft Condensed Matter
Abstract

Active solids emerge from self-actuating components interacting with each other to form crystalline patterns. In equilibrium, commensurability underpins our understanding of nanoscale friction and particle-level dynamics of crystals. However, these concepts have yet to be imported into the realm of active matter. Here, we develop an experimental platform and a theoretical description for microscopic clusters composed of active particles confined and self-assembled into small crystals. In our experiments, these crystallites form upon circular confinement of active rollers, with a magic number of 61 rollers per well. Competition between solidity and self propulsion leads to self shearing and complex flow inversion behaviour, along with self sliding states and activity induced melting. We discover active stick slip dynamics, which periodically switch between a commensurate static state and an incommensurate self-sliding state characterised by a train of localised defects. We describe the steady state behaviour using a discretised model of active hydrodynamics. We then quantify the intermittent stick slip dynamics using a self-propelled extension of the Frenkel Kontorova (FK) model, a fundamental workhorse of slipping and flow in crystals. Our findings in a colloidal model system point to a wealth of phenomena in incommensurate active solids as design principles for both assembly and robotics down to the nanoscale.

Published
2023

6. Matching markets with farsighted couples

Author

Atay, Ata, Funck, Sylvain, Mauleon, Ana, and Vannetelbosch, Vincent

Subjects
Economics - Theoretical Economics, Computer Science - Computer Science and Game Theory, 91B68
Abstract

We adopt the notion of the farsighted stable set to determine which matchings are stable when agents are farsighted in matching markets with couples. We show that a singleton matching is a farsighted stable set if and only if the matching is stable. Thus, matchings that are stable with myopic agents remain stable when agents become farsighted. Examples of farsighted stable sets containing multiple non-stable matchings are provided for markets with and without stable matchings. For couples markets where the farsighted stable set does not exist, we propose the DEM farsighted stable set to predict the matchings that are stable when agents are farsighted.

Published
2023

7. Limited Farsightedness in Priority-Based Matching

Author

Atay, Ata, Mauleon, Ana, and Vannetelbosch, Vincent

Subjects
Economics - Theoretical Economics, Computer Science - Computer Science and Game Theory
Abstract

We consider priority-based matching problems with limited farsightedness. We show that, once agents are sufficiently farsighted, the matching obtained from the Top Trading Cycles (TTC) algorithm becomes stable: a singleton set consisting of the TTC matching is a horizon-$k$ vNM stable set if the degree of farsightedness is greater than three times the number of agents in the largest cycle of the TTC. On the contrary, the matching obtained from the Deferred Acceptance (DA) algorithm may not belong to any horizon-$k$ vNM stable set for $k$ large enough., Comment: arXiv admin note: text overlap with arXiv:2212.07108

Published
2022

8. School Choice with Farsighted Students

Author

Atay, Ata, Mauleon, Ana, and Vannetelbosch, Vincent

Subjects
Economics - Theoretical Economics, Computer Science - Computer Science and Game Theory
Abstract

We consider priority-based school choice problems with farsighted students. We show that a singleton set consisting of the matching obtained from the Top Trading Cycles (TTC) mechanism is a farsighted stable set. However, the matching obtained from the Deferred Acceptance (DA) mechanism may not belong to any farsighted stable set. Hence, the TTC mechanism provides an assignment that is not only Pareto efficient but also farsightedly stable. Moreover, looking forward three steps ahead is already sufficient for stabilizing the matching obtained from the TTC.

Published
2022

9. Immunogenicity of a third dose with mRNA-vaccines in the ChAdOx1-S/BNT162b2 vaccination regimen against SARS-CoV-2 variants

Author

Javier García-Pérez, Alberto M. Borobia, Mayte Pérez-Olmeda, Antonio Portolés, Luis Castaño, Magdalena Campins-Artí, María Jesús Bertrán, Mercedes Bermejo, José Ramón Arribas, Andrea López, Ana Ascaso-del-Rio, Eunate Arana-Arri, Inmaculada Fuentes Camps, Anna Vilella, Almudena Cascajero, María Teresa García-Morales, María Castillo de la Osa, Carla Pérez Ingidua, David Lora, Paloma Jiménez-Santana, Silvia Pino-Rosa, Agustín Gómez de la Cámara, Erick De La Torre-Tarazona, Esther Calonge, Raquel Cruces, Cristóbal Belda-Iniesta, José Alcamí, Jesús Frías, Antonio J. Carcas, Francisco Díez-Fuertes, Lucía Díaz García, Elena Ramírez García, Enrique Seco Meseguer, Stefan Mark Stewart Balbàs, Alicia Marín Candón, Irene García García, Mikel Urroz Elizalde, Paula de la Rosa, Marta Sanz García, Cristina López Crespo, Vega Mauleón Martínez, Raquel de Madariaga Castell, Laura Vitón Vara, Rocío Prieto-Pérez, Emilio Vargas-Castrillón, Leonor Laredo, Ouhao Zhu-Huang, Teresa Iglesias, Natale Imaz-Ayo, Susana Meijide, Aitor García de Vicuña, Ana Santorcuato, Iraide Exposito, Sara de Benito, Alazne Bustinza, Mikel Gallego, Dolores García-Vázquez, Ana Belén de la Hoz, Gustavo Pérez-Nanclares, Josu Aurrekoetxea, Ines Urrutia, Rosa Martínez-Salazar, Janire Orcajo, Begoña Calvo, June Corcuera, Olaia Velasco, Anibal Aguayo, Xavier Martínez-Gómez, Susana Otero-Romero, Lluis Armadans, Blanca Borras-Bermejo, Oleguer Parés, Sonia Uriona, José Ángel Rodrigo Pendás, Cesar Llorente, José Santos, Laia Pinós, Lina Camacho, Judith Riera, Carla Sans, Antonia Agustí, Carmen Altadill, Carla Aguilar Blancafort, Gisela Gili Serrat, Aitana Plaza, Anna Feliu Prius, Maria Margarita Torrens, Esther Palacio, Gloria Torres, Julia Calonge, Elena Ballarin Alins, Eulàlia Pérez-Esquirol, Lourdes Vendrell Bosch, Marta Aldea, Eugènia Mellado, Ma Ángeles Marcos, Marta Tortajada, Lourdes E. Barón-Mira, Laura Granés, Sulayman Lazaar, Sara Herranz, Montserrat Malet, Sebastiana Quesada, Anna Llupià, Victoria Olivé, Antoni Trilla, Begoña Gómez, Elisenda González, Sheila Romero, Francisco Javier Gámez, Cristina Casals, Laura Burunat, Juan José Castelló, Patricia Fernández, Josep Lluís Bedini, Jordi Vila, Juan Carlos Hurtado, Isabel Jado, Giovanni Fedele, Concepción Perea, Mónica González, Isabel Grajera, María Ángeles Murillo, Pilar Balfagón, Irene Díaz-Marín, and Gema González-Pardo

Subjects
Immunology, Immune response, Science
Abstract

Summary: CombiVacS study has demonstrated a strong immune response of the heterologous ChAdOx1-S/BNT162b2 vaccine combination. The primary outcomes of the study were to assess the humoral immune response against SARS-CoV-2, 28 days after a third dose of a mRNA vaccine, in subjects that received a previous prime-boost scheme with ChAdOx1-S/BNT162b2. Secondary outcomes extended the study to 3 and 6 months. The third vaccine dose of mRNA-1273 in naive participants previously vaccinated with ChAdOx1-S/BNT162b2 regimen reached higher neutralizing antibodies titers against the variants of concern Delta and BA.1 lineage of Omicron compared with those receiving a third dose of BNT162b2 at day 28. These differences between BNT162b2 and mRNA-1273 arms were observed against the ancestral variant G614 at day 90. Suboptimal neutralizing response was observed against BQ.1.1, XBB.1.5/XBB.1.9, and JN.1 in a relevant proportion of individuals 180 days after the third dose, even after asymptomatic Omicron breakthrough infections. EudraCT (2021-001978-37); ClinicalTrials.gov (NCT04860739).

Published
2024
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13. Immunogenicity of a third dose with mRNA-vaccines in the ChAdOx1-S/BNT162b2 vaccination regimen against SARS-CoV-2 variants

Author

García, Lucía Díaz, García, Elena Ramírez, Meseguer, Enrique Seco, Stewart Balbàs, Stefan Mark, Candón, Alicia Marín, García, Irene García, Elizalde, Mikel Urroz, Rosa, Paula de la, García, Marta Sanz, Crespo, Cristina López, Martínez, Vega Mauleón, de Madariaga Castell, Raquel, Vara, Laura Vitón, Prieto-Pérez, Rocío, Vargas-Castrillón, Emilio, Laredo, Leonor, Zhu-Huang, Ouhao, Iglesias, Teresa, Imaz-Ayo, Natale, Meijide, Susana, García de Vicuña, Aitor, Santorcuato, Ana, Exposito, Iraide, de Benito, Sara, Bustinza, Alazne, Gallego, Mikel, García-Vázquez, Dolores, Belén de la Hoz, Ana, Pérez-Nanclares, Gustavo, Aurrekoetxea, Josu, Urrutia, Ines, Martínez-Salazar, Rosa, Orcajo, Janire, Calvo, Begoña, Corcuera, June, Velasco, Olaia, Aguayo, Anibal, Martínez-Gómez, Xavier, Otero-Romero, Susana, Armadans, Lluis, Borras-Bermejo, Blanca, Parés, Oleguer, Uriona, Sonia, Rodrigo Pendás, José Ángel, Llorente, Cesar, Santos, José, Pinós, Laia, Camacho, Lina, Riera, Judith, Sans, Carla, Agustí, Antonia, Altadill, Carmen, Blancafort, Carla Aguilar, Serrat, Gisela Gili, Plaza, Aitana, Prius, Anna Feliu, Torrens, Maria Margarita, Palacio, Esther, Torres, Gloria, Calonge, Julia, Alins, Elena Ballarin, Pérez-Esquirol, Eulàlia, Bosch, Lourdes Vendrell, Aldea, Marta, Mellado, Eugènia, Marcos, M<ce:sup loc='post">a</ce:sup> Ángeles, Tortajada, Marta, Barón-Mira, Lourdes E., Granés, Laura, Lazaar, Sulayman, Herranz, Sara, Malet, Montserrat, Quesada, Sebastiana, Llupià, Anna, Olivé, Victoria, Trilla, Antoni, Gómez, Begoña, González, Elisenda, Romero, Sheila, Gámez, Francisco Javier, Casals, Cristina, Burunat, Laura, Castelló, Juan José, Fernández, Patricia, Bedini, Josep Lluís, Vila, Jordi, Hurtado, Juan Carlos, Jado, Isabel, Fedele, Giovanni, Perea, Concepción, González, Mónica, Grajera, Isabel, Murillo, María Ángeles, Balfagón, Pilar, Díaz-Marín, Irene, González-Pardo, Gema, García-Pérez, Javier, Borobia, Alberto M., Pérez-Olmeda, Mayte, Portolés, Antonio, Castaño, Luis, Campins-Artí, Magdalena, Bertrán, María Jesús, Bermejo, Mercedes, Arribas, José Ramón, López, Andrea, Ascaso-del-Rio, Ana, Arana-Arri, Eunate, Fuentes Camps, Inmaculada, Vilella, Anna, Cascajero, Almudena, García-Morales, María Teresa, Castillo de la Osa, María, Pérez Ingidua, Carla, Lora, David, Jiménez-Santana, Paloma, Pino-Rosa, Silvia, Gómez de la Cámara, Agustín, De La Torre-Tarazona, Erick, Calonge, Esther, Cruces, Raquel, Belda-Iniesta, Cristóbal, Alcamí, José, Frías, Jesús, Carcas, Antonio J., and Díez-Fuertes, Francisco

Published
2024
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14. In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAFV600E lung adenocarcinoma

Author

Nokin, Marie-Julie, Darbo, Elodie, Richard, Elodie, San José, Sonia, de Hita, Sergio, Prouzet-Mauleon, Valérie, Turcq, Béatrice, Gerardelli, Laura, Crake, Rebekah, Velasco, Valérie, Koopmansch, Benjamin, Lambert, Frederic, Xue, Jenny Y., Sang, Ben, Horne, Julie, Ziemons, Eric, Villanueva, Alberto, Blomme, Arnaud, Herfs, Michael, Cataldo, Didier, Calvayrac, Olivier, Porporato, Paolo, Nadal, Ernest, Lito, Piro, Jänne, Pasi A., Ricciuti, Biagio, Awad, Mark M., Ambrogio, Chiara, and Santamaría, David

Published
2024
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15. Dynamics and Interactions of Quincke Roller Clusters: from Orbits and Flips to Excited States

Author

Mauleon-Amieva, Abraham, Allen, Michael P., and Royall, C. Patrick

Subjects
Condensed Matter - Soft Condensed Matter
Abstract

Active matter systems may be characterised by the conversion of energy into active motion, e.g. the self-propulsion of microorganisms. Artificial active colloids form models which exhibit essential properties of more complex biological systems but are amenable to laboratory experiments. While most experimental models consist of spheres, such as Janus particles, active particles of different shapes are less understood. In particular, interactions between such active colloidal "molecules" are largely unexplored. Here, we investigate the motion of active colloidal molecules and the interactions between them. We focus on self-assembled dumbbells and trimers powered by an external electric field. For dumbbells, we observe an activity-dependent behaviour of spinning, circular and orbital motion. Moreover, collisions between dumbbells lead to the hierarchical self-assembly of tetramers and hexamers, both of which form rotational excited states. On the other hand, trimers exhibit a novel type of flipping motion that leads to trajectories reminiscent of a honeycomb lattice., Comment: 8 pages, 4 figures

Published
2021

17. [Translated article] Drug Survival in Cyclosporine Treatment for Moderate to Severe Atopic Dermatitis: Analysis of the Spanish Atopic Dermatitis Registry (BIOBADATOP)

Author

Couselo-Rodríguez, C., Batalla, A., Carrascosa, J.M., Chicharro, P., González-Quesada, A., de la Cueva, P., Giménez-Arnau, A.M., Gilaberte, Y., Rodríguez-Serna, M., Montero-Vilchez, T., Ruiz-Villaverde, R., Elosua-González, M., Silvestre-Salvador, J.F., Munera-Campos, M., Sánchez-Pérez, J., Carretero, G., Mauleón-Fernández, C., Curto-Barredo, L., Ballano-Ruiz, A., Botella-Estrada, R., Arias-Santiago, S., Navarro-Triviño, F.J., Roustan-Gullón, G., Betlloch, I., del Alcázar, E., Abalde-Pintos, M.T., Suárez-Perez, J., García-Doval, I., Descalzo, M.Á., and Flórez, Á.

Published
2024
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18. Supervivencia de la ciclosporina en el tratamiento de la dermatitis atópica moderada-grave: Registro Español de Dermatitis Atópica (BIOBADATOP)

Author

Couselo-Rodríguez, C., Batalla, A., Carrascosa, J.M., Chicharro, P., González-Quesada, A., de la Cueva, P., Giménez-Arnau, A.M., Gilaberte, Y., Rodríguez-Serna, M., Montero-Vilchez, T., Ruiz-Villaverde, R., Elosua-González, M., Silvestre-Salvador, J.F., Munera-Campos, M., Sánchez-Pérez, J., Carretero, G., Mauleón-Fernández, C., Curto-Barredo, L., Ballano-Ruiz, A., Botella-Estrada, R., Arias-Santiago, S., Navarro-Triviño, F.J., Roustan-Gullón, G., Betlloch, I., del Alcázar, E., Abalde-Pintos, M.T., Suárez-Perez, J., García-Doval, I., Descalzo, M.Á., and Flórez, Á.

Published
2024
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19. Perfil clínico, epidemiológico y respuesta al tratamiento, en función de la comorbilidad atópica asociada en la dermatitis atópica. Experiencia del registro BIOBADATOP

Author

Peris-Espino, V., Munera-Campos, M., Chicharro, P., González Quesada, A., Menéndez, Á. Flórez, de la Cueva Dobao, P., Giménez Arnau, A.M., Gilaberte Calzada, Y., Rodríguez Serna, M., Montero-Vilchez, T., Silvestre Salvador, J.F., Ruiz-Villaverde, R., Elosua-González, M., del Alcázar-Viladomiu, E., Sánchez-Pérez, J., Carretero Hernández, G., Batalla, A., Suh Oh, H.J., Couselo-Rodríguez, C., Mauleón Fernández, C., Curto-Barredo, L., Bertolín-Colilla, M., Navarro-Bielsa, A., Ballano Ruiz, A., Botella Estrada, R., Arias-Santiago, S., Sanabria-de-la-Torre, R., Betlloch-Mas, I., Navarro-Triviño, F.J., Roustan Gullón, G., Rosell-Díaz, A., Loro-Pérez, M., Suárez-Pérez, J., García-Doval, I., Descalzo-Gallego, M.Á., and Carrascosa Carrillo, J.M.

Published
2024
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21. University Entrepreneurship at the Service of Rural Society. The RuralYU Project as an Action Learning Process

Author

María Begoña Sáiz Mauleón, Irene Badía Madrigal, Rita Gorriz Salanova, Inés Mondragón Pons, Victoria Olcina Marcos, Pedro Sáez Martínez, Pablo Tortosa Juanes, Guillem García Martín, and María Cos Aznar

Subjects
university entrepreneurship, project-based learning, social innovation, rural development, yudesign, Technology, Technology (General), T1-995, Social Sciences, Social sciences (General), H1-99
Abstract

The article presents the RuralYU university entrepreneurship project, developed by the Youth University Design (YUDesign) Spontaneous Generation (GE) group of the School of Design Engineering (ETSID), at the Polytechnic University of Valencia (UPV). RuralYU aspires to reduce rural depopulation in collaboration with university students, who, by carrying out academic work, cover specific needs with the aim of strengthening rural development. The idea of ​​an inter-university collaboration programme with the rural world arose after having won the Vodafone Foundation’s Project Lab 2021 national contest within the framework of GLOBAL CHANGE with the proposal “RuralLife4Good. Accommodation grant programme for the empowerment of rural environments”. The winning proposal, which was implemented as a pilot project in Ràfol de Salem during the 2021-2022 academic year, values ​​the importance of the university at the service of society, in this case as an axis of urgent and necessary activation to avoid rural abandonment.

Published
2023
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22. TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory

Author

Ausejo-Mauleon, Iker, Labiano, Sara, de la Nava, Daniel, Laspidea, Virginia, Zalacain, Marta, Marrodán, Lucía, García-Moure, Marc, González-Huarriz, Marisol, Hervás-Corpión, Irati, Dhandapani, Laasya, Vicent, Silvestre, Collantes, Maria, Peñuelas, Iván, Becher, Oren J., Filbin, Mariella G., Jiang, Li, Labelle, Jenna, de Biagi-Junior, Carlos A.O., Nazarian, Javad, Laternser, Sandra, Phoenix, Timothy N., van der Lugt, Jasper, Kranendonk, Mariette, Hoogendijk, Raoull, Mueller, Sabine, De Andrea, Carlos, Anderson, Ana C., Guruceaga, Elizabeth, Koschmann, Carl, Yadav, Viveka Nand, Gállego Pérez-Larraya, Jaime, Patiño-García, Ana, Pastor, Fernando, and Alonso, Marta M.

Published
2023
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23. Expanding HIV clinical monitoring: the role of CD4, CD8, and CD4/CD8 ratio in predicting non-AIDS events

Author

Jarrín, Inma, Dalmau, David, Navarro, M. Luisa, González, M. Isabel, Garcia, Federico, Poveda, Eva, Iribarren, Jose Antonio, Gutiérrez, Félix, Rubio, Rafael, Vidal, Francesc, Berenguer, Juan, González, Juan, Muñoz-Fernández, M. Ángeles, Jarrín, Inmaculada, Moreno, Cristina, Rava, Marta, Izquierdo, Rebeca, Mauleón, Elba, Portilla, Joaquín, Portilla, Irene, Merino, Esperanza, García, Gema, Agea, Iván, Sánchez-Payá, José, Rodríguez, Juan Carlos, Giner, Livia, Reus, Sergio, Boix, Vicente, Torrus, Diego, Pérez, Verónica, Portilla, Julia, Gómez, Juan Luís, Hernández, Jehovana, Lirola, Ana López, García, Dácil, Díaz-Flores, Felicitas, Alonso, M. Mar, Pelazas, Ricardo, Alemán, M. Remedios, Asensi, Víctor, Rivas Carmenado, María Eugenia, Suarez-Zarracina, Tomás, Pulido, Federico, Bisbal, Otilia, Hernando, M. Asunción, Rial, David, de Lagarde, María, Arce, Octavio, Pinto, Adriana, Bermejo, Laura, Santacreu, Mireia, Navarro, Roser, Gonzalez, Candela, Aramburu, M. José, Camino, Xabier, Ángel von Wichmann, Miguel, Goenaga, Miguel Ángel, Bustinduy, M. Jesús, Azkune, Harkaitz, Ibarguren, Maialen, Kortajarena, Xabier, Álvarez-Rodriguez, Ignacio, Gil, Leire, Martínez, Lourdes, Robledano, Catalina, Masiá, Mar, Padilla, Sergio, Adsuar, Araceli, Pascual, Rafael, Fernández, Marta, Galiana, Antonio, García, José Alberto, Barber, Xavier, Agullo, Vanessa, Abellán, Javier Garcia, Pascual, Reyes, Telenti, Guillermo, Guillén, Lucia, Botella, Ángela, Muga, Roberto, Sanvisens, Arantza, Fuster, Daniel, Gutierrez, Isabel, López, Juan Carlos, Ramírez, Margarita, Padilla, Belén, Gijón, Paloma, Aldamiz-Echevarría, Teresa, Tejerina, Francisco, Diez, Cristina, Pérez, Leire, Fanciulli, Chiara, Corral, Saray, Martí, Anna, Peraire, Joaquín, Viladés, Consuelo, Vargas, Montserrat, Olona, Montserrat, Rull, Anna, Alba, Verónica, Yeregui, Elena, Masip, Jenifer, García-Pardo, Graciano, Bertomeu, Frederic Gómez, Espineira, Sonia, Montero, Marta, Cuéllar, Sandra, Blanes, Marino, Tasias, María, Calabuig, Eva, Salavert, Miguel, Fernández, Juan, Segarra, Inmaculada, González-García, Juan, Delgado, Ana, Arnalich, Francisco, Arribas, José Ramón, Bernardino, Jose Ignacio, Castro, Juan Miguel, Escosa, Luis, Herranz, Pedro, Hontañón, Victor, García-Bujalance, Silvia, García, Milagros, González-Baeza, Alicia, Martín-Carbonero, M. Luz, Mayoral, Mario, Mellado, M. Jose, Esteban, Rafael, Montejano, Rocío, Montes, M. Luisa, Moreno, Victoria, Pérez-Valero, Ignacio, Rodés, Berta, Rúa, Guadalupe, Sainz, Talía, Sendagorta, Elena, Valencia, Eulalia, Busca, Carmen, Cano, Joanna, Cardiñanos, Julen, de Miguel, Rosa, Blanco, Jose Ramón, Pérez-Martínez, Laura, Oteo, José Antonio, Ibarra, Valvanera, Metola, Luis, Sanz, Mercedes, Arazo, Piedad, Sampériz, Gloria, Martinez, Marina, Jaén, Angels, Sanmartí, Montse, Cairó, Mireia, Martinez-Lacasa, Javier, Velli, Pablo, Font, Roser, Xercavins, Mariona, Alonso, Noemí, Aiello, Francesco, Rivero, María, Piérola, Beatriz, Goikoetxea, Maider, Gracia, María, Ibero, Carlos, Moreno, Estela, Repáraz, Jesús, Navarro, Gemma, Garcia, Manel Cervantes, Isbert, Sonia Calzado, Vilasaro, Marta Navarro, Garcia, Belen Lopez, Santos, Ignacio de los, Santos, Alejandro de los, Sanz, Jesús, García-Fraile, Lucio, Martín, Enrique, Sánchez-Cerrillo, Ildefonso, Calvet, Marta, Barrios, Ana, Bautista, Azucena, Sáez, Carmen, Ciudad, Marianela, Gutiérrez, Ángela, Moreno, Santiago, Campo, Santos del, Casado, José Luis, Dronda, Fernando, Moreno, Ana, Pérez, M. Jesús, Serrano, Sergio, Vivancos, M<ce:sup loc='post">a</ce:sup> Jesús, Martínez-Sanz, Javier, Vallejo, Alejandro, Sanchez, Matilde, Pérez-Molina, Jose Antonio, Hermida, José Manuel, Bernal, Enrique, Alcaraz, Antonia, Bravo, Joaquín, Muñoz, Ángeles, Tomás, Cristina, Martínez, Mónica, Villalba, M. Carmen, García, Federico, Martínez, Clara, Hernández, José, Medina, Leopoldo Muñoz, Álvarez, Marta, Chueca, Natalia, Vinuesa, David, de Salazar, Adolfo, Fuentes, Ana, Guirao, Emilio, Viñuela, Laura, Ruiz-Sancho, Andrés, Anguita, Francisco, Del Romero, Jorge, Raposo, Montserrat, Rodríguez, Carmen, Puerta, Teresa, Carrió, Juan Carlos, Vera, Mar, Ballesteros, Juan, Ayerdi, Oskar, Baza, Begoña, Orviz, Eva, Antela, Antonio, Losada, Elena, Riera, Melchor, Peñaranda, María, Ribas, M. Angels, Campins, Antoni A., Garcia-Gazalla, Mercedes, Fanjul, Francisco J., Murillas, Javier, Homar, Francisco, Vilchez, Helem H., Martin, Luisa, Payeras, Antoni, Santos, Jesús, López, María, Gómez, Crisitina, Viciana, Isabel, Palacios, Rosario, López-Cortés, Luis Fernando, Espinosa, Nuria, Roca, Cristina, Llaves, Silvia, Tiraboschi, Juan Manuel, Imaz, Arkaitz, Silva, Ana Karina, Saumoy, María, Scévola, Sofía Catalina, Curran, Adrián, Falcó, Vicenç, Navarro, Jordi, Burgos, Joaquin, Suanzes, Paula, García, Jorge, Descalzo, Vicente, Álvarez, Patricia, Planas, Bibiana, Sanchiz, Marta, Rodríguez, Lucía, Olalla, Julián, Sánchez, M José, Pérez, Javier, Arco, Alfonso del, Torre, Javier de la, Prada, José Luis, Martínez, Onofre Juan, Martinez, Lorena, Vera, Francisco Jesús, García, Josefina, Alcaraz, Begoña, Sánchez Guirao, Antonio Jesús, Mena, Alvaro, Castro, Angeles, Pernas, Berta, Vázquez, Pilar, López, Soledad, Ibarra, Sofía, García, Guillermo, Mirena, Josu, Ferrero, Oscar Luis, López, Josefina, Cámara, M. Mar, Peña, Mireia de la, Lopez, Miriam, Lopez, Iñigo, Lombide, Itxaso, Polo, Victor, de Miguel, Joana, Galera, Carlos, Fernández, Marian, Albendin, Helena, Castillo, Antonia, Iborra, Asunción, Moreno, Antonio, Merlos, M. Angustias, Vidal, Asunción, Amador, Concha, Pasquau, Francisco, Gil, Concepcion, Algado, Jose Tomás, Suarez-García, Inés, Malmierca, Eduardo, González-Ruano, Patricia, Ruiz, M. Pilar, Pascual, José Francisco, Sáez, Elena, Balsalobre, Luz, López, M. Villa, Omar, Mohamed, Herrero, Carmen, Gómez, M. Amparo, Alberto de Zarraga, Miguel, Pérez, Desiré, Estrada, Vicente, Sanz, Nieves, Cabello, Noemí, García, Jorge Vergas, Núñez, Maria Jose, Sagastagoitia, Iñigo, Górgolas, Miguel, Cabello, Alfonso, Álvarez, Beatriz, Prieto, Laura, Carrillo, Irene, Sanz, José, Arranz, Alberto, Hernández, Cristina, Novella, María, Galindo, M. José, Ferrer, Ana, Román, Antonio Rivero, Ruíz, Inma, Juárez, Antonio Rivero, López, Pedro, Machuca, Isabel, Frias, Mario, Camacho, Ángela, Pérez, Ignacio, Corona, Diana, Cervero, Miguel, Torres, Rafael, Pineda, Juan Antonio, Rincón, Pilar, Macías, Juan, Real, Luis Miguel, Corma, Anais, Gonzalez-Serna, Alejandro, Pérez, Alexandre, Morano, Luis, Miralles, Celia, Ocampo, Antonio, Pousada, Guillermo, Patiño, Lucía, Dueñas, Carlos, Gutiérrez, Sara, Tapia, Elena, Novoa, Cristina, Egües, Xjoylin, Telleria, Pablo, Díaz-Álvarez, Jorge, Rosas Cancio-Suarez, Marta, Ron, Raquel, Iribarren, José Antonio, Ruiz Sancho, Andrés, Cabello, Noemi, and Serrano-Villar, Sergio

Published
2023
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25. Competing Active and Passive Interactions Drive Amoeba-like Living Crystallites and Ordered Bands

Author

Mauleon-Amieva, Abraham, Mosayebi, Majid, Hallett, James E., Turci, Francesco, Liverpool, Tanniemola B., van Duijneveldt, Jeroen S., and Royall, C. Patrick

Subjects
Condensed Matter - Soft Condensed Matter, Condensed Matter - Statistical Mechanics
Abstract

Swimmers and self-propelled particles are physical models for the collective behaviour and motility of a wide variety of living systems, such as bacteria colonies, bird flocks and fish schools. Such artificial active materials are amenable to physical models which reveal the microscopic mechanisms underlying the collective behaviour. Here we study colloids in a DC electric field. Our quasi-two-dimensional system of electrically-driven particles exhibits a rich and exotic phase behaviour. At low field strengths, electrohydrodynamic flows lead to self-organisation into crystallites with hexagonal order. Upon self-propulsion of the particles due to Quincke rotation, we find an ordered phase of active matter in which the motile crystallites constantly change shape and collide with one another. At higher field strengths, this "dissolves" to an active gas. We parameterise a particulate simulation model which reproduces the experimentally observed phases and, at higher field strengths predicts an activity-driven demixing to band-like structures.

Published
2019
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26. [Translated article] BIOBADATOP Spanish Atopic Dermatitis Registry: Description and Early Findings

Author

Munera-Campos, M., Chicharro, P., Gonzalez Quesada, A., Flórez Menéndez, Á., de la Cueva Dobao, P., Gimenez Arnau, A.M., Gilaberte Calzada, Y., Rodríguez Serna, M., Montero-Vilchez, T., Silvestre, J.F., Elosua-González, M., del Alcázar, E., Santamaría, C., Sánchez-Pérez, J., Carretero Hernández, G., Batalla, A., Jin Suh Oh, H., Mauleón Fernández, C., Curto Barredo, L., Bertolín-Colilla, M., Navarro Bielsa, A., Ballano Ruiz, A., Botella Estrada, R., Arias Santiago, S., Betlloch, I., Roustan Gullón, G., Rosell Díaz, A., Descalzo, M.A., García-Doval, I., and Carrascosa, J.M.

Published
2023
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27. BIOBADATOP: Registro Español de Dermatitis Atópica. Descripción y primeros resultados

Author

Munera-Campos, M., Chicharro, P., Gonzalez Quesada, A., Flórez Menéndez, Á., de la Cueva Dobao, P., Gimenez Arnau, A.M., Gilaberte Calzada, Y., Rodríguez Serna, M., Montero-Vilchez, T., Silvestre, J.F., Elosua-González, M., del Alcázar, E., Santamaría, C., Sánchez-Pérez, J., Carretero Hernández, G., Batalla, A., Jin Suh Oh, H., Mauleón Fernández, C., Curto Barredo, L., Bertolín-Colilla, M., Navarro Bielsa, A., Ballano Ruiz, A., Botella Estrada, R., Arias Santiago, S., Betlloch, I., Roustan Gullón, G., Rosell Díaz, A., Descalzo, M.A., García-Doval, I., and Carrascosa, J.M.

Published
2023
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31. Expanding HIV clinical monitoring: the role of CD4, CD8, and CD4/CD8 ratio in predicting non-AIDS eventsResearch in context

Author

Javier Martínez-Sanz, Jorge Díaz-Álvarez, Marta Rosas, Raquel Ron, José Antonio Iribarren, Enrique Bernal, Félix Gutiérrez, Andrés Ruiz Sancho, Noemi Cabello, Julián Olalla, Santiago Moreno, Sergio Serrano-Villar, Inma Jarrín, David Dalmau, M. Luisa Navarro, M. Isabel González, Federico Garcia, Eva Poveda, Jose Antonio Iribarren, Rafael Rubio, Francesc Vidal, Juan Berenguer, Juan González, M. Ángeles Muñoz-Fernández, Inmaculada Jarrín, Cristina Moreno, Marta Rava, Rebeca Izquierdo, Elba Mauleón, Joaquín Portilla, Irene Portilla, Esperanza Merino, Gema García, Iván Agea, José Sánchez-Payá, Juan Carlos Rodríguez, Livia Giner, Sergio Reus, Vicente Boix, Diego Torrus, Verónica Pérez, Julia Portilla, Juan Luís Gómez, Jehovana Hernández, Ana López Lirola, Dácil García, Felicitas Díaz-Flores, M. Mar Alonso, Ricardo Pelazas, M. Remedios Alemán, Víctor Asensi, María Eugenia Rivas Carmenado, Tomás Suarez-Zarracina, Federico Pulido, Otilia Bisbal, M. Asunción Hernando, David Rial, María de Lagarde, Octavio Arce, Adriana Pinto, Laura Bermejo, Mireia Santacreu, Roser Navarro, Candela Gonzalez, M. José Aramburu, Xabier Camino, Miguel Ángel von Wichmann, Miguel Ángel Goenaga, M. Jesús Bustinduy, Harkaitz Azkune, Maialen Ibarguren, Xabier Kortajarena, Ignacio Álvarez-Rodriguez, Leire Gil, Lourdes Martínez, Catalina Robledano, Mar Masiá, Sergio Padilla, Araceli Adsuar, Rafael Pascual, Marta Fernández, Antonio Galiana, José Alberto García, Xavier Barber, Vanessa Agullo, Javier Garcia Abellán, Reyes Pascual, Guillermo Telenti, Lucia Guillén, Ángela Botella, Roberto Muga, Arantza Sanvisens, Daniel Fuster, Isabel Gutierrez, Juan Carlos López, Margarita Ramírez, Belén Padilla, Paloma Gijón, Teresa Aldamiz-Echevarría, Francisco Tejerina, Cristina Diez, Leire Pérez, Chiara Fanciulli, Saray Corral, Anna Martí, Joaquín Peraire, Consuelo Viladés, Montserrat Vargas, Montserrat Olona, Anna Rull, Verónica Alba, Elena Yeregui, Jenifer Masip, Graciano García-Pardo, Frederic Gómez Bertomeu, Sonia Espineira, Marta Montero, Sandra Cuéllar, Marino Blanes, María Tasias, Eva Calabuig, Miguel Salavert, Juan Fernández, Inmaculada Segarra, Juan González-García, Ana Delgado, Francisco Arnalich, José Ramón Arribas, Jose Ignacio Bernardino, Juan Miguel Castro, Luis Escosa, Pedro Herranz, Victor Hontañón, Silvia García-Bujalance, Milagros García, Alicia González-Baeza, M. Luz Martín-Carbonero, Mario Mayoral, M. Jose Mellado, Rafael Esteban, Rocío Montejano, M. Luisa Montes, Victoria Moreno, Ignacio Pérez-Valero, Berta Rodés, Guadalupe Rúa, Talía Sainz, Elena Sendagorta, Eulalia Valencia, Carmen Busca, Joanna Cano, Julen Cardiñanos, Rosa de Miguel, Jose Ramón Blanco, Laura Pérez-Martínez, José Antonio Oteo, Valvanera Ibarra, Luis Metola, Mercedes Sanz, Piedad Arazo, Gloria Sampériz, Marina Martinez, Angels Jaén, Montse Sanmartí, Mireia Cairó, Javier Martinez-Lacasa, Pablo Velli, Roser Font, Mariona Xercavins, Noemí Alonso, Francesco Aiello, María Rivero, Beatriz Piérola, Maider Goikoetxea, María Gracia, Carlos Ibero, Estela Moreno, Jesús Repáraz, Gemma Navarro, Manel Cervantes Garcia, Sonia Calzado Isbert, Marta Navarro Vilasaro, Belen Lopez Garcia, Ignacio de los Santos, Alejandro de los Santos, Jesús Sanz, Lucio García-Fraile, Enrique Martín, Ildefonso Sánchez-Cerrillo, Marta Calvet, Ana Barrios, Azucena Bautista, Carmen Sáez, Marianela Ciudad, Ángela Gutiérrez, Santos del Campo, José Luis Casado, Fernando Dronda, Ana Moreno, M. Jesús Pérez, Sergio Serrano, Ma Jesús Vivancos, Alejandro Vallejo, Matilde Sanchez, Jose Antonio Pérez-Molina, José Manuel Hermida, Antonia Alcaraz, Joaquín Bravo, Ángeles Muñoz, Cristina Tomás, Mónica Martínez, M. Carmen Villalba, Federico García, Clara Martínez, José Hernández, Leopoldo Muñoz Medina, Marta Álvarez, Natalia Chueca, David Vinuesa, Adolfo de Salazar, Ana Fuentes, Emilio Guirao, Laura Viñuela, Andrés Ruiz-Sancho, Francisco Anguita, Jorge Del Romero, Montserrat Raposo, Carmen Rodríguez, Teresa Puerta, Juan Carlos Carrió, Mar Vera, Juan Ballesteros, Oskar Ayerdi, Begoña Baza, Eva Orviz, Antonio Antela, Elena Losada, Melchor Riera, María Peñaranda, M. Angels Ribas, Antoni A. Campins, Mercedes Garcia-Gazalla, Francisco J. Fanjul, Javier Murillas, Francisco Homar, Helem H. Vilchez, Luisa Martin, Antoni Payeras, Jesús Santos, María López, Crisitina Gómez, Isabel Viciana, Rosario Palacios, Luis Fernando López-Cortés, Nuria Espinosa, Cristina Roca, Silvia Llaves, Juan Manuel Tiraboschi, Arkaitz Imaz, Ana Karina Silva, María Saumoy, Sofía Catalina Scévola, Adrián Curran, Vicenç Falcó, Jordi Navarro, Joaquin Burgos, Paula Suanzes, Jorge García, Vicente Descalzo, Patricia Álvarez, Bibiana Planas, Marta Sanchiz, Lucía Rodríguez, M José Sánchez, Javier Pérez, Alfonso del Arco, Javier de la Torre, José Luis Prada, Onofre Juan Martínez, Lorena Martinez, Francisco Jesús Vera, Josefina García, Begoña Alcaraz, Antonio Jesús Sánchez Guirao, Alvaro Mena, Angeles Castro, Berta Pernas, Pilar Vázquez, Soledad López, Sofía Ibarra, Guillermo García, Josu Mirena, Oscar Luis Ferrero, Josefina López, M. Mar Cámara, Mireia de la Peña, Miriam Lopez, Iñigo Lopez, Itxaso Lombide, Victor Polo, Joana de Miguel, Carlos Galera, Marian Fernández, Helena Albendin, Antonia Castillo, Asunción Iborra, Antonio Moreno, M. Angustias Merlos, Asunción Vidal, Concha Amador, Francisco Pasquau, Concepcion Gil, Jose Tomás Algado, Inés Suarez-García, Eduardo Malmierca, Patricia González-Ruano, M. Pilar Ruiz, José Francisco Pascual, Elena Sáez, Luz Balsalobre, M. Villa López, Mohamed Omar, Carmen Herrero, M. Amparo Gómez, Miguel Alberto de Zarraga, Desiré Pérez, Vicente Estrada, Nieves Sanz, Noemí Cabello, Jorge Vergas García, Maria Jose Núñez, Iñigo Sagastagoitia, Miguel Górgolas, Alfonso Cabello, Beatriz Álvarez, Laura Prieto, Irene Carrillo, José Sanz, Alberto Arranz, Cristina Hernández, María Novella, M. José Galindo, Ana Ferrer, Antonio Rivero Román, Inma Ruíz, Antonio Rivero Juárez, Pedro López, Isabel Machuca, Mario Frias, Ángela Camacho, Ignacio Pérez, Diana Corona, Miguel Cervero, Rafael Torres, Juan Antonio Pineda, Pilar Rincón, Juan Macías, Luis Miguel Real, Anais Corma, Alejandro Gonzalez-Serna, Alexandre Pérez, Luis Morano, Celia Miralles, Antonio Ocampo, Guillermo Pousada, Lucía Patiño, Carlos Dueñas, Sara Gutiérrez, Elena Tapia, Cristina Novoa, Xjoylin Egües, and Pablo Telleria

Subjects
HIV, Non-AIDS events, Neoplasia, Cardiovascular event, CD4/CD8 ratio, Medicine, Medicine (General), R5-920
Abstract

Summary: Background: While a low CD4/CD8 ratio during HIV treatment correlates with immunosenescence, its value in identifying patients at an increased risk for clinical events remains unclear. Methods: We analyzed data from the CoRIS cohort to determine whether CD4 count, CD8 count, and CD4/CD8 ratio at year two of antiretroviral therapy (ART) could predict the risk of serious non-AIDS events (SNAEs) during the next five years. These included major adverse cardiovascular events, non-AIDS-defining malignancies, and non-accidental deaths. We used pooled logistic regression with inverse probability weighting to estimate the survival curves and cumulative risk of clinical events. Findings: The study included 4625 participants, 83% male, of whom 200 (4.3%) experienced an SNAE during the follow-up period. A CD4/CD8 ratio

Published
2023
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32. Galectin-3 inhibition boosts the therapeutic efficacy of Semliki Forest virus in pediatric osteosarcoma

Author

Herrador-Cañete, Guillermo, Zalacain, Marta, Labiano, Sara, Laspidea, Virginia, Puigdelloses, Montserrat, Marrodan, Lucía, Garcia-Moure, Marc, Gonzalez-Huarriz, Marisol, Marco-Sanz, Javier, Ausejo-Mauleon, Iker, de la Nava, Daniel, Hernández-Osuna, Reyes, Martínez-García, Javier, Silva-Pilipich, Noelia, Gurucega, Elisabeth, Patiño-García, Ana, Hernández-Alcoceba, Rubén, Smerdou, Cristian, and Alonso, Marta M.

Published
2022
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34. Prehabilitation in Frail Octogenarian and Nonagenarian Patients in Colorectal Cancer Surgery: Short- and Medium-Term Outcomes.

Author

Ramírez-Martín, Raquel, Mauleón Ladrero, Coro, Gazo Martínez, Jose Antonio, Déniz-González, Victoria, Martín Maestre, Isabel, Corral-Sastre, Lucía, Villajos-Guijarro, María, Menéndez-Colino, Rocío, Pascual Miguelañez, Isabel, and González-Montalvo, Juan Ignacio

Subjects
*OCTOGENARIANS, *SURGICAL complications, *NONAGENARIANS, *ANEMIA treatment, *OLDER patients
Abstract

Background: There is still limited evidence on the results of prehabilitation in very old frail patients. The aim of this study is to analyze the outcomes and course of octogenarian and nonagenarian patients undergoing prehabilitation before surgery for colorectal cancer (CRC). Methods: a prospective study was conducted in a tertiary hospital from 2018 to 2022. All patients diagnosed with CRC over 80 years old and proposed for surgery were included. A comprehensive geriatric assessment (CGA) for frailty detection was performed, and the therapeutic decision was taken by the multidisciplinary tumor committee. Prehabilitation led by the geriatric team was performed. The rate of medical and surgical complications, hospital stay, in-hospital mortality, and first-year mortality were recorded. Results: CRC surgery was proposed in 184 patients >80 years. After a multidisciplinary decision, surgery was performed on 126 (68.5%) patients, of whom 12 (0.5%) were nonagenarians. Fifty percent of octogenarians and 86% of nonagenarians were frail. Prehabilitation consisted of the following: adapted physical exercise (100%); oral nutritional supplementation (73.8%); anemia treatment (59.5%); delirium prevention (5.6%); antidepressant treatment (15.9%); vitamin D supplementation (21.4%); and pharmacological deprescription (38.1%). The post-surgical complication rate was low (4.3% surgical and 29.4% medical complications), and in-hospital mortality was very low (3.2%). Nonagenarian patients had a higher rate of complications compared to octogenarians (OR 4.0 (95% CI 1.13–14.12))—mainly heart failure (OR 4.68 (95% CI 1.21–18.09))—but there were no differences in hospital stay or first-year mortality. Conclusions: prehabilitation in very old patients with CRC surgery is possible and provides good results. [ABSTRACT FROM AUTHOR]

Published
2024
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41. Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project

Author

Abdelnour, C., Aguilera, N., Alarcon, E., Alegret, M., Benaque, A., Boada, M., Buendia, M., Cañabate, P., Carracedo, A., Corbatón, A., de Rojas, I., Diego, S., Espinosa, A., Gailhajenet, A., García González, P., Gil, S., Guitart, M., González Pérez, A., Hernández, I., Ibarria, M., Lafuente, A., Macias, J., Maroñas, O., Martín, E., Martínez, M.T., Marquié, M., Mauleón, A., Monté-Rubio, G., Montrreal, L., Moreno-Grau, S., Moreno, M., Orellana, A., Ortega, G., Pancho, A., Pelejà, E., Pérez-Cordon, A., Pineda, J.A., Preckler, S., Quintela, I., Real, L.M., Rodríguez-Gómez, O., Rosende-Roca, M., Ruiz, A., Ruiz, S., Sáez, M.E., Sanabria, A., Santos-Santos, M.A., Serrano-Rios, M., Sotolongo-Grau, O., Tárraga, L., Valero, S., Vargas, L., Adarmes-Gómez, A.D., Alarcón-Martín, E., Álvarez, I., Álvarez, V., Amer-Ferrer, Goo, Antequera, M., Antúnez, C., Baquero, M., Bernal, M., Blesa, R., Buiza-Rueda, D., Bullido, M.J., Burguera, J.A., Calero, M., Carrillo, F., Carrión-Claro, M., Casajeros, M.J., Clarimón, J., Cruz-Gamero, J.M., de Pancorbo, M.M., del Ser, T., Diez-Fairen, M., Fortea, J., Franco, E., Frank-García, A., García-Alberca, J.M., Garcia Madrona, S., Garcia-Ribas, G., Gómez-Garre, P., Hevilla, S., Jesús, S., Espinosa, Labrador, Lage, C., Legaz, A., Lleó, A., López de Munáin, A., López-García, S., Macias, D., Manzanares, S., Marín, M., Marín-Muñoz, J., Marín, T., Martín Montes, A., Martínez, B., Martínez, C., Martínez, V., Martínez-Lage Álvarez, P., Medina, M., Mendioroz Iriarte, M., Menéndez-González, M., Mir, P., Molinuevo, J.L., Pastor, A.B., Pastor, P., Pérez Tur, J., Periñán-Tocino, T., Piñol Ripoll, G., Rábano, A., Real de Asúa, D., Rodrigo, S., Rodríguez-Rodríguez, E., Royo, J.L., A, Ruiz, Sanchez del Valle Díaz, R., Sánchez-Juan, P., Sastre, I., Vicente, M.P., Vivancos, L., Moreno-Grau, Sonia, de Rojas, Itziar, Hernández, Isabel, Quintela, Inés, Montrreal, Laura, Alegret, Montserrat, Hernández-Olasagarre, Begoña, Madrid, Laura, González-Perez, Antonio, Maroñas, Olalla, Rosende-Roca, Maitée, Mauleón, Ana, Vargas, Liliana, Lafuente, Asunción, Abdelnour, Carla, Rodríguez-Gómez, Octavio, Gil, Silvia, Santos-Santos, Miguel Ángel, Espinosa, Ana, Ortega, Gemma, Sanabria, Ángela, Pérez-Cordón, Alba, Cañabate, Pilar, Moreno, Mariola, Preckler, Silvia, Ruiz, Susana, Aguilera, Nuria, Pineda, Juan Antonio, Macías, Juan, Alarcón-Martín, Emilio, Sotolongo-Grau, Oscar, Marquié, Marta, Monté-Rubio, Gemma, Valero, Sergi, Benaque, Alba, Clarimón, Jordi, Bullido, Maria Jesus, García-Ribas, Guillermo, Pástor, Pau, Sánchez-Juan, Pascual, Álvarez, Victoria, Piñol-Ripoll, Gerard, García-Alberca, Jose Maria, Royo, José Luis, Franco, Emilio, Mir, Pablo, Calero, Miguel, Medina, Miguel, Rábano, Alberto, Ávila, Jesús, Antúnez, Carmen, Real, Luis Miguel, Orellana, Adelina, Carracedo, Ángel, Sáez, María Eugenia, Tárraga, Lluís, Boada, Mercè, and Ruiz, Agustín

Published
2019
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42. Leading Universities in Tourism and Hospitality Research: A Bibliometric Overview

Author

Mulet-Forteza, Carles, Mauleón-Méndez, Emilio, Merigó, José M., Genovart-Balaguer, Juanabel, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Ferrer-Comalat, Joan Carles, editor, Linares-Mustarós, Salvador, editor, and Merigó, José M., editor

Published
2020
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46. Immunogenicity and reactogenicity of BNT162b2 booster in ChAdOx1-S-primed participants (CombiVacS): a multicentre, open-label, randomised, controlled, phase 2 trial

Author

Martínez de Soto, Lucía, Rodríguez Mariblanca, Amelia, Díaz García, Lucía, Ramírez García, Elena, Seco Meseguer, Enrique, Stewart Balbás, Stefan Mark, Marín Candón, Alicia, García García, Irene, Urroz Elizalde, Mikel, Monserrat Villatoro, Jaime, de la Rosa, Paula, Sanz García, Marta, López Crespo, Cristina, Mauleón Martínez, Vega, de Madariaga Castell, Raquel, Vitón Vara, Laura, García Rodríguez, Julio, Buño, Antonio, López Granados, Eduardo, Cámara, Carmen, Rey Cuevas, Esther, Ayllon García, Pilar, Jiménez González, María, Hernández Rubio, Victoria, Moraga Alapont, Paloma, Sánchez, Amparo, Prieto, Rocío, Llorente Gómez, Silvia, Miragall Roig, Cristina, Aparicio Marlasca, Marina, de la Calle, Fernando, Arsuaga, Marta, Duque, Blanca, Meijide, Susana, García de Vicuña, Aitor, Santorcuato, Ana, Expósito, Iraide, de Benito, Sara, Andia, Joseba, Castillo, Cristina, Irurzun, Esther, Camino, Jesús, Temprano, Mikel, Goikoetxea, Josune, Bustinza, Alazne, Larrea, Maialen, Gallego, Mikel, García-Vázquez, Dolores, de la Hoz, Ana Belén, Pérez-Nanclares, Gustavo, Pérez-Guzmán, Estíbaliz, Idoyaga, Eneko, Lamela, Adriana, Oteo, Jesús, Castillo de la Osa, María, Hernández Gutiérrez, Lourdes, Andrés Galván, María Elena, Calonge, Esther, Bermejo, Mercedes, de la Torre-Tarazona, Erick Humberto, Cascajero, Almudena, Fedele, Giovanni, Perea, Concepción, Cervera, Isabel, Bodega-Mayor, Irene, Montes-Casado, María, Portolés, Pilar, Baranda, Jana, Granés, Laura, Lazaar, Sulayman, Herranz, Sara, Mellado, María Eugènia, Tortajada, Marta, Malet, Montserrat, Quesada, Sebastiana, Vilella, Anna, Llupià, Anna, Olivé, Victoria, Trilla, Antoni, Gómez, Begoña, González, Elisenda, Romero, Sheila, Gámez, Francisco Javier, Casals, Cristina, Burunat, Laura, Castelló, Juan José, Fernández, Patricia, Bedini, Josep Lluís, Vila, Jordi, Aguilar, Carla, Altadill, Carmen, Armadans, Lluis, Borras-Bermejo, Blanca, Calonge, Julia, Camacho, Lina, Feliu, Anna, Gili, Gisela, Llorente, Cesar, Martínez-Gómez, Xavier, Otero-Romero, Susana, Palacio, Esther, Parés, Oleguer, Pinós, Laia, Plaza, Aitana, Riera-Arnau, Judit, Rodrigo-Pendás, José Angel, Sans, Carla, Santos, José, Torres, Gloria, Torrens, Margarita, Uriona, Sonia, Ballarin Alins, Elena, Pérez Esquirol, Eulàlia, Vendrell Bosch, Lourdes, Laredo Velasco, Leonor, Uribe López, Diana, González Rojano, Esperanza, Sánchez-Craviotto, Manuel, Rivas Paterna, Ana Belén, Hernán-Gómez, Teresa Iglesias, Rodríguez Galán, Natalia, Gil Marín, José Antonio, Álvarez-Morales, Verónica, Navalpotro, Ana Belén, Jiménez-Santamaría, M Dolores, Cardós, M Carmen, Hermoso, Elena, García-Arenillas, Mar, Pérez Macías, Natalia, Domingo Fernández, Alexandra, López Picado, Amanda, Quiñones, Jorge Mario, Deidda, Nicoletta, García-Franco, Ana, Torvisco, José María, Borobia, Alberto M, Carcas, Antonio J, Pérez-Olmeda, Mayte, Castaño, Luis, Bertran, María Jesús, García-Pérez, Javier, Campins, Magdalena, Portolés, Antonio, González-Pérez, María, García Morales, María Teresa, Arana-Arri, Eunate, Aldea, Marta, Díez-Fuertes, Francisco, Fuentes, Inmaculada, Ascaso, Ana, Lora, David, Imaz-Ayo, Natale, Barón-Mira, Lourdes E, Agustí, Antonia, Pérez-Ingidua, Carla, Gómez de la Cámara, Agustín, Arribas, José Ramón, Ochando, Jordi, Alcamí, José, Belda-Iniesta, Cristóbal, and Frías, Jesús

Published
2021
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47. Assessing the Energy Efficiency Gains and Savings in China’s 2060 Carbon-Neutral Plan

Author

Chong Zhang and Ignacio Mauleón

Subjects
China carbon neutral, forecasting energy demand, long-run simulation, energy efficiency gains, bootstrap trend estimation, Technology
Abstract

At the end of 2020, the Chinese government announced the pledge to become carbon neutral in the year 2060. Simultaneously, quality growth objectives were established, which were environmentally friendly and promoted the health and wellbeing of the population. The first objective of this study is to assess the gains in energy efficiency and the savings in energy demand that this commitment implies. Secondly, the feasibility of achieving these objectives of savings and efficiency increases is discussed based on an international analysis. The method is based on a quantitative estimate of the primary energy demand throughout the period from 1965 up to the year 2060. For this purpose, long historical series taken from reliable international sources are analyzed. The methodology applied to estimate and project future energy demand is new and based on several steps: The first consists of analyzing the trends of the series and estimating the relationships between them using a robust procedure. Secondly, equilibrium relationships are estimated, which avoids the eventual instabilities involved in the estimation of dynamic models. The third characteristic is based on the bootstrap, estimating and simulating the model by selecting random samples of different sizes from the available dataset. The simulations generate a complete probability distribution for the expected energy demand, which also allows for carrying out a risk analysis, assessing the risk of the demand becoming significantly larger than the expected average. The first result obtained is that the primary energy demand forecast for 2060 is much higher than the demand of the official forecasts by almost three times. However, taking into account the objective to replace 85% of fossil sources with renewables, this discrepancy is greatly reduced and becomes approximately 50% higher than the official forecast. If the savings analyzed in relevant international references are accounted for, then an additional reduction of even up to 40% of this demand could be achieved, so that the final demand would fall further, close to official forecasts. The main and final conclusion is that although the objective of making the Chinese economy carbon neutral by 2060 is feasible, it implies a radical transformation that will necessarily require a determined and unwavering political commitment throughout the entire period considered.

Published
2023
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