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Вступ. Лептоспіроз є одним з найпоширеніших зоонозів у світі, виявляється на усіх заселених континентах. Актуальність проблеми лептоспірозу зумовлена тим, що він завдає значну соціальну та економічну шкоду. Підвищують соціальне значення лептоспірозу й спорадичні хвороби, що залишаються нерозпізнаними та перебігають під іншими діагнозами і в подальшому призводять до ускладнень стану здоров’я хворої людини. Лептоспіроз з різних причин залишається неконтрольованою нозологічною формою. Через значне поширення на території України ця інфекційна хвороба є небезпечною, особливо для військових колективів. Мета. Визначити епідеміологічні особливості лептоспірозу серед населення України та у військових колективах. Матеріали і методи. У роботі використані офіційні статистичні дані Центру громадського здоров’я України щодо захворюваності населення на лептоспіроз за формою 1/МЕД та звіти Регіональних санітарно-епідеміологічних управлінь для вивчення інфекційної захворюваності серед військовослужбовців Збройних Сил України за 2021–2022 рр. Для цього застосовані методи комплексного епідеміологічного аналізу, зокрема статистичний та бібліографічний. Результати. В Україні ензоотичні території з лептоспірозу виявлені майже в усіх областях. За останні 20 років відмічено помітне зростання захворюваності населення на лептоспіроз. Вивчаючи показники захворюваності населення України на лептоспіроз було встановлено, що у 2022 році цей показник підвищився на 7,66 % і становив 0,70 на 100 тис. людей (130 випадків), проти 0,64 на 100 тис. осіб (122 випадки) у 2021 році. Хвороба реєструвалася спорадично, проте спалахів не зареєстровано. Гендерний розподіл залишається незмінним: чоловіки займають частку у 84,41 % серед осіб, що захворіли на лептоспіроз, а жінки – 15,59 % відповідно. Міське населення хворіє з однаковою частотою як і сільське. Діти становили лише 6,1 %. Враховуючи літньо-осінню сезонність хвороби встановлено, що показники захворюваності у 2022 році були дещо вищими ніж у 2021 році. Було виявлено підвищення показників у червні – 0,03 на 100 тис. населення (13 випадків) у 2022 році з максимальним підйомом захворюваності у серпні 2022 року – 0,09 на 100 тис. населення (39 випадків). Вивчаючи захворюваність на лептоспіроз серед військовослужбовців Збройних Сил України відповідно до регіонів відповідальності Регіональних санітарно-епідеміологічних управлінь (РСЕУ) встановлено, що природні і антропургічні осередки зареєстровано в усіх областях на території регіону відповідальності 108 РСЕУ. В 2022 році захворювання людей на лептоспіроз реєструвалося на території Дніпропетровської області. Так з червня по жовтень захворіло 6 військовослужбовців за контрактом та 40 військовослужбовців призваних за мобілізацією. В інших РСЕУ ця хвороба у 2021–2022 роках не встановлена. Висновки. Враховуючи клімато-географічні особливості території та велику кількість видів диких та свійських тварин, які є резервуаром лептоспір, Україна належить до територій з високою поширеністю лептоспірозу як серед цивільного населення, так і серед військовослужбовців.

Ten laboratory rats were experimentally invaded per os with the Eustrongylides excisus (Jäegerskiold, 1909) nematode larvae (L3–L4) received from Perca fluviatialis (Linnaeus, 1758), caught in the water area of the Dnipro-Buh Estuary, Ukraine. The aim of the experimental study was to measure the pathogenic effect of the given parasite on the mammals’ organisms by means of the histological analysis of the affected organs of the infected rats. The researched animals were divided into two groups. The experiment lasted 15 days; the second group was a control group. The histological analysis showed purulent-serous and purulent-fibrinous peritonitis, acute circulatory disorders in brain tissues (signs of hypoxic-ischemic lesions of the brainstem in the form of neuronal changes) and the heart (partial spasm of arteries and edema of interstitial myocardial tissue); pathological changes in the lungs (acute interstitial purulent pneumonia, acute focal emphysema of the lungs), liver (acute exudative hepatitis), kidneys (signs of shock reaction) and intestines (acute serous-purulent enteritis). Formation of non-specific granulomas was noticed, which contained the fragments of the parasitic larvae. The acute course of the purulent-serous and purulent-fibrinous inflammatory processes in the organs of the invaded rats was noticed; signs of systemic inflammatory response syndrome with pronounced distributive vascular leukocytosis in the studied organs.

The aim: To review real-life regulatory-dependent study design and data management practices of post marketing multicenter studies of medical devices conducted in 2021 in Ukraine and Poland. Materials and methods: This article presents the case study of 4 post marketing multicenter studies of medical devices conducted in 2021 in Ukraine and European Union. Results: The case study presented effective cross-border cooperation between Ukrainian and European actors. Despite the gaps in Ukrainian legislative framework on medical devices, complex solutions on employment of the most stringent regulatory provisions led to appropriate study design. Usage of the highly compliant electronic data capture led to fast-track study start-up and solid clinical data collection. Conclusions: Publications on real-life regulatory-dependent clinical trials conduct might be essential to innovate the regulatory system in Ukraine. The cross-border cooperation might assist the advancement of clinical trials industry in Ukraine. Gaps in medical devices regulations in Ukraine impede the context-specific clinical trials solutions for biotech industry in Ukraine. The regulatory framework and practice in Ukraine may be perceived as externally driven due to gaps in medical devices regulations, lack of capacities of domestic notified bodies and business interests of Sponsors.

Continuous circular plates on a variable elastic foundation are considered. It is assumed that the reaction of the foundation is described by the Winkler model with the variable modulus of subgrade reaction, defined as a polynomial. We present in the analytical form all required computational formulas, which make it possible to conduct axisymmetric bending tests of continuous circular plates on a continuously variable elastic foundation with a variable continuously distributed load, specified by a polynomial. Examples of the calculation of plates are presented. Two possible cases of boundary conditions are considered: hinging and fixing along the plate contour. A calculation of plates acted upon by a constant load is performed by a method developed by the authors, with a modulus of subgrade reaction varying linearly and parabolically. To verity the results obtained, a modeling and calculation of the same plates is performed via a software package implementing the finite element method. Comparison of the results obtained proves the feasibility of the proposed algorithm, which requires no structural discretization. Due to analytical solutions obtained, the calculation accuracy is improved. The method provides a more reliable results on bending of plates relative to approximate methods. Therefore, it is a good alternative to approximate methods in the axisymmetric bending analysis of continuous circular plates on a variable elastic bed.

Objective The aim: The identification and determination of needs that the population of older age groups have in medical and social services on the basis of health data and the results of a survey. Patients and methods Material and methods: Because of bibliographic, epidemiological, medical-statistical, analytical methods the research has investigated the problems of healthy aging, tendencies in population health of the population of Ukraine of senior age groups during 2000-2017, features and tendencies of health of a sample contingent of urban population of elderly age according to appeals in health care facilities during 2009-2019. The use of the sociological method, the self-evaluation of elderly people of their own health, characteristics of lifestyle and medical activity are determined, the needs of older people in medical and social services were assessed. Results Results: Negative tendencies to increase during 2000-2017 the prevalence of pathology among the population older than working age by 22.8%, including blood diseases in 2 times, endocrine system - in 1.8 times, urogenital system - by 1.5 times, digestive organs - by 1.4 times, tumors and nervous system - by 1.3 times. Among the urban elderly population, the prevalence of sensory diseases, including ear and eye diseases, endocrine disorders, injuries and poisonings, has increased, and mental health indicators have deteriorated. The sociological survey found a low level of self-esteem (31.5±3.5 per 100 had health problems, 10.1±2.3 are significant). Self-medication was practiced by 76.4±3.2 per 100 respondents, 74.2±3.3 were not followed or they violated the doctor's recommendations. 56.2 ±3.7 per 100 respondents had physical examinations in the non-right time 29.7±3.4 had not it.There was a significant prevalence of risk factors, including hypodynamics (21.9±3.1 per 100), tobacco use (29.8±3.4), malnutrition (37.1±3.6), overweight (obesity) (32, 6±3.5), arterial hypertension (37.6±3.6), hypercholesterolemia (28.7±3.4), glucosemia 16.3±2.8). The research has discovered the needs of older people in health care and social services, inter alia in preventive counseling (65.2±3.6 per 100), the introduction of electronic technologies in health care (68.5±3.5), information educational services on health issues (67.4±3.5), provision of services in hospitals at home (66.3±3.5), in increasing the availability of rehabilitation (43.8±3.7), specialized counseling (34.3±3.6) and emergency medical care (16.2±2.8), improvement of socio-economic determinants (78.0±3.1), introduction of activities (48.3±3.7), joint training programs for older people (42.1±3.7), the development of certain skills, the use of technical means, assistive devices (67.4±3.5), the formation of a conducive to better health environment (58, 4±3.7). Conclusion Conclusions: The low level of the elderly people's health, the tendency to increase the burden of disease, the prevalence of risk factors for disease and low medical activity lead tosignificant needs for medical and social services of preventive, treatment-diagnostic, rehabilitation, improving socio-economic determinants, measures to reduce social isolation.

The paper presents the results of a study of the stress-strain state of a circular plate of constant cylindrical stiffness, which lies on a variable elastic foundation and is under the influence of a continuously distributed transverse load. Twelve variants of calculation are considered ‒ six for a steel round plate and six more ‒ for a concrete round plate under two conditions of fixing and three different laws of variation of the bed coefficient. To solve the problem, the finite element method implemented in the LIRA-SAPR software package is used. It is noted that in the case when the bedding coefficient is a variable value depending on the coordinate in which the foundation settlement is determined, the analytical approach leads to the need to solve the corresponding differential equations with variable coefficients. Therefore, calculations of circular and annular plates lying on a variable elastic foundation by means of analytical solutions of differential equations are extremely rare in scientific periodicals and are of a private nature. An effective method for the analytical solution of differential equations with variable coefficients for a number of problems in mechanics was proposed by one of the authors of the article, however, the application of the method to the calculation of a circular plate on an elastic foundation with a variable bed coefficient requires verification, therefore, here we consider the features of the finite element analysis of such a plate under different boundary conditions and different laws of variation of the bed coefficient. In all versions, the results completely coincide with the known results of bending of slabs that do not have an elastic base and in the case when this base exists and its resistance is constant. The discrepancy here is very insignificant ‒ in the third significant digit after the decimal point for deflection when hinged and in the second for moments. In case of rigid clamping, the deflections and moments also differ from the corresponding values of the known solutions in the second significant digit after the decimal point.

В рамках агентно-орієнтованого підходу з метою підвищення варіативності середовища підготовки диспетчерів управління повітряним рухом у статті удосконалено метод адаптації поведінки агентів навчального середовища інтелектуальної навчальної системи, що ґрунтується на знаннях про результати взаємодії агентів. На етапі внесення змін до параметрів підсистеми планування при настоюванні систем моделювання поведінки агентів запропоновано використовувати механізм самонастроювання. Для управління процесом самонастроювання поведінки інтелектуальних агентів в статті розроблено інструментарій адаптації системи планування поведінки агента. Застосування моделей поведінки агентів із методами планування дозволить збільшити показник успішності реалізації очікуваної поведінки агентів при побудові інтелектуальних навчальних систем. Запропонований у статті підхід адаптації поведінки агентів навчального середовища інтелектуальної навчальної системи дозволить підвищити його варіативність. Як наслідок, така інтелектуальна навчальна система дозволить вивести на якісно новий рівень підготовку диспетчерів управління повітряним

The article provides data on keeping lambs in small farms and homesteads in the Cherkasy region. Coprological studies have identified eimeria oocysts, in particular E. crandallis, E. intricate, E. arloingi, E. faurei, which are found in lambs and cause a lot of damage to their bodies. The presence of eimeria oocysts is associated with insufficient sanitary measures in cages and pens, which significantly affect the economic indicators of the profitability of small farms, which in turn limit the increase in the attractiveness of sheep farming. It has been established that eimeriosis in lambs often runs chronically, sometimes acutely. In lambs from the age of one month, characteristic clinical signs are observed: anemia of visible mucous membranes, diarrhea, depression, weakness and death. It has been noted that the intestinal epithelium of lambs is damaged during infestation. This worsens their assimilation of nutrients from food. It has been established that sick or sick lambs cause significant economic losses for such small farms, in particular, the profitability of wool, leather, and meat production decreases. It has been studied that at the beginning of the infestation, visible clinical signs in lambs depend on certain factors, in particular their age, weaning from the ewe, feeding, sanitary conditions in cages and pens, as well as various stressful situations. In older lambs, there is a tendency to infection with eіmeria. At the same time, eіmeriosis in them can be chronic or not clinically manifested, but Eimeria oocysts are excreted in their feces in a small amount, compared to one-month-old lambs during an acute course. In this regard, it is important, taking into account the time of year, to carry out diagnostic studies and medical and preventive measures for lambs of different age groups in small farms and homesteads.

The spin Seebeck effect was studied in thin films of hexagonal ferrites of W-type SrCo2−xZnxFe16O27 with x = 0, 1, and 2 and Z-type with the composition Sr3Co2Fe24O41. The present data were compared with the previously obtained data on Y-type Ba2Zn2−xCoxFe12O22 with x = 0 and 2. Our work showed that the SSE signal can also be generated in materials with complicated crystal and magnetic structures. Hexaferrites with the magnetic easy plane were selected except for uniaxial W-type with x = 2, for which the highest saturated SSE 0.144 μV/K was observed; however, magnetic field above 1 T must be applied to achieve saturation. For low field application, hexaferrites with easy magnetization in ab-plane are more suitable, namely, Y-type with x = 2 or W-type with x = 1. SSE is suppressed in Co-substituted hexaferrites due to the random distribution of Co among various sites. Therefore, the Co cations interfere with the long-range magnetic ordering and diminish the spin-wave propagation. Additional suppression of SSE might be invoked by the higher magnetic anisotropy of the Co-substituted hexaferrites, which opens a gap in the magnon spectrum and, thus, reduces the contribution of lower energy magnons with longer diffusion length.

We present a combined experimental and theoretical study of the longitudinal and transverse thermoelectric properties of ferrimagnetic spinels $\mathrm{Cu}{\mathrm{Cr}}_{2}{X}_{4}$ ($X=\mathrm{S}$, Se, Te). The thermoelectric power of all studied phases is positive and consists of two contributions; an almost linear diffusive thermopower observed at high temperature, and a strong enhancement below ${T}_{C}$ attributed to magnon drag. The diffusive part of thermopower and resistivity decreases from $X=\mathrm{S}$ to Te, whereas the magnon drag enhancement is the biggest for $X=\mathrm{Se}$, which has also the highest ${T}_{C}$. The thermopower was calculated by DFT method using GGA, $\mathrm{GGA}+U, \mathrm{GGA}+\text{oeeHyb}$, and mBJ potentials. A good agreement with the experimental thermopower was achieved using GGA potential for $X=\mathrm{S}$ and with mBJ potential for $X=\mathrm{Te}$. The mBJ potential, which was designed for $sp$-type semiconductors, better describes the valence bands of $\mathrm{Cu}{\mathrm{Cr}}_{2}{\mathrm{Te}}_{4}$ that exhibit stronger $sp$-orbitals character than sulfide and selenide. The anomalous Nernst effect (ANE) is negative at room temperature for all phases, the highest absolute value $\ensuremath{\sim}1.5 \ensuremath{\mu}\mathrm{V}$/K is observed for $X=\mathrm{Te}$ and Se around room temperature, whereas ANE for $X=\mathrm{S}$ is much smaller. A sign change of ANE to positive is observed at 285 K for $X=\mathrm{S}$ and at 65 K for $X=\mathrm{Se}$. The trend of anomalous Nernst conductivity is reproduced by Berry phase calculations if the renormalization of the bands due to the strong correlation effects is taken into account.

Thin films of Sr3Co2Fe24O41 hexaferrite were prepared through the chemical solution deposition method using SrTiO3(1 1 1) single crystal substrates. The influence of the annealing temperature and annealing duration time on the phase composition, structural, microstructural and magnetic properties was investigated by examining the out- and in-plane crystallographic orientation, temperature and magnetic-field dependence of the magnetization, and surface topography. The Rietveld analysis performed on the XRD patterns indicates Sr3Co2Fe24O41 being the dominant phase, according to the XRD texture analysis the orientation relationship between Z ferrite and substrate can be expressed as (0 0 l)Z || (1 1 1)STO || and [1 1 0]Z || [1 0 0]STO. The magnetization data show anomalies in the magnetic behavior occurring at temperatures close to the room temperature that are characteristic for collinear to non-collinear spin structure transitions. The magnetic-field dependence of the magnetization proves soft magnetic character of ferrite film together with pronounced magnetic anisotropy, and shows a two-step increase of magnetization at lower fields (≤1 T) before it becomes almost saturated at around 2 T.

The iron sulphide ${\mathrm{Fe}}_{3}{\mathrm{S}}_{4}$ (greigite) is similar to its oxide counterpart ${\mathrm{Fe}}_{3}{\mathrm{O}}_{4}$ (magnetite) as to the crystal structure and ferrimagnetic order, but differs in electronic states. The ab initio calculations have evidenced $p$-type carriers at three spin-minority and three spin-majority Fermi surfaces, which is in contrast to the half-metallic character of magnetite with $n$-type carriers at three spin-minority Fermi surfaces. The transport properties including Hall and Nernst effects have been studied over the range 2--300 K by using nanogranular ceramics prepared by cold isostatic pressing of ${\mathrm{Fe}}_{3}{\mathrm{S}}_{4}$ particles with the mean crystallite size of ${d}_{\mathrm{XRD}}\ensuremath{\approx}80$ and 30 nm, respectively. The samples show metalliclike electrical resistivity with large residual value at $T$ \ensuremath{\rightarrow} 0 K. The $p$-type character of the charge carriers is reflected by the positive sign of both the thermopower and Hall effect. Temperature dependencies of the electrical resistivity, thermal conductivity, and thermopower are analyzed by considering processes of the grain boundary and defect intragrain scattering; simultaneously the role of magnons and their dynamics in electronic and heat transport is revealed. The Nernst and Hall effects show dominant contributions of anomalous type (ANE and AHE) with signs exactly opposite to those of ${\mathrm{Fe}}_{3}{\mathrm{O}}_{4}$, i.e., positive AHE and negative ANE in ${\mathrm{Fe}}_{3}{\mathrm{S}}_{4}$. The results are interpreted by evoking the original Callen treatment of thermoelectric and thermomagnetic phenomena using Onsager equations. Scaling between the longitudinal and transverse components of the electrical resistivity and thermoelectric conductivity tensors is checked. The analysis of the temperature dependent AHE using the relation between transverse and longitudinal resistivity ${\ensuremath{\rho}}_{yx}^{A}(T)\ensuremath{\sim}{\ensuremath{\rho}}_{xx}{(T)}^{n}$ gives the characteristic exponent $n=1.15$, which is close to the $n=1$ predicted by the skew-scattering mechanism.

The aim: The identification and determination of needs that the population of older age groups have in medical and social services on the basis of health data and the results of a survey.Material and methods: Because of bibliographic, epidemiological, medical-statistical, analytical methods the research has investigated the problems of healthy aging, tendencies in population health of the population of Ukraine of senior age groups during 2000-2017, features and tendencies of health of a sample contingent of urban population of elderly age according to appeals in health care facilities during 2009-2019. The use of the sociological method, the self-evaluation of elderly people of their own health, characteristics of lifestyle and medical activity are determined, the needs of older people in medical and social services were assessed.Results: Negative tendencies to increase during 2000-2017 the prevalence of pathology among the population older than working age by 22.8%, including blood diseases in 2 times, endocrine system - in 1.8 times, urogenital system - by 1.5 times, digestive organs - by 1.4 times, tumors and nervous system - by 1.3 times. Among the urban elderly population, the prevalence of sensory diseases, including ear and eye diseases, endocrine disorders, injuries and poisonings, has increased, and mental health indicators have deteriorated. The sociological survey found a low level of self-esteem (31.5±3.5 per 100 had health problems, 10.1±2.3 are significant). Self-medication was practiced by 76.4±3.2 per 100 respondents, 74.2±3.3 were not followed or they violated the doctor's recommendations. 56.2 ±3.7 per 100 respondents had physical examinations in the non-right time 29.7±3.4 had not it.There was a significant prevalence of risk factors, including hypodynamics (21.9±3.1 per 100), tobacco use (29.8±3.4), malnutrition (37.1±3.6), overweight (obesity) (32, 6±3.5), arterial hypertension (37.6±3.6), hypercholesterolemia (28.7±3.4), glucosemia 16.3±2.8). The research has discovered the needs of older people in health care and social services, inter alia in preventive counseling (65.2±3.6 per 100), the introduction of electronic technologies in health care (68.5±3.5), information educational services on health issues (67.4±3.5), provision of services in hospitals at home (66.3±3.5), in increasing the availability of rehabilitation (43.8±3.7), specialized counseling (34.3±3.6) and emergency medical care (16.2±2.8), improvement of socio-economic determinants (78.0±3.1), introduction of activities (48.3±3.7), joint training programs for older people (42.1±3.7), the development of certain skills, the use of technical means, assistive devices (67.4±3.5), the formation of a conducive to better health environment (58, 4±3.7).Conclusions: The low level of the elderly people's health, the tendency to increase the burden of disease, the prevalence of risk factors for disease and low medical activity lead tosignificant needs for medical and social services of preventive, treatment-diagnostic, rehabilitation, improving socio-economic determinants, measures to reduce social isolation.

We report the anomalous Nernst effect (ANE) in large-grain ceramics, nanogranular ceramics, and nanogranular thin films of ${\mathrm{La}}_{0.7}{\mathrm{Sr}}_{0.3}\mathrm{Co}{\mathrm{O}}_{3}$, measured over the temperature range 5--300 K. The study is complemented with thermopower, resistivity, and magnetic measurements. The temperature-dependent ANE below the Curie temperature ${T}_{\mathrm{C}}$ (240--250 K) is analyzed with the help of longitudinal resistivity and Seebeck using a previously proposed formula derived by a combination of Onsager reciprocity, the Mott formula, and the relation between transverse and longitudinal resistivity, ${\ensuremath{\rho}}_{xy}\ensuremath{\propto}{\ensuremath{\rho}}_{xx}^{n}$. We observe a characteristic exponent n \ensuremath{\sim} 0.4 in agreement with the universal scaling for the bad-metal-type conduction regime. The nanogranular samples are characterized by higher resistivity, lower saturated magnetization, and a higher coercive field compared to large-grain ceramics. On the other hand, the magnitude of the ANE is independent of grain size. This observation likely insinuates that the characteristic length scale characterizing the ANE in ${\mathrm{La}}_{0.7}{\mathrm{Sr}}_{0.3}\mathrm{Co}{\mathrm{O}}_{3}$ is below the grain size of nanogranular samples \ensuremath{\sim}40 nm. Therefore, the ANE associated with the bad-metal regime is independent of barriers associated with grain surface, which are responsible for activated resistivity and lowered magnetization due to a magnetically ``dead'' layer. The observation that the advantage of the higher coercive field of nanogranular samples is not deteriorated by a lower ANE is important for possible applications in zero magnetic field.

Bulk ceramics and thick nanogranular films of mixed-valence cobaltite ${({\mathrm{Pr}}_{1\ensuremath{-}y}{\mathrm{Y}}_{y})}_{0.7}{\mathrm{Ca}}_{0.3}\mathrm{Co}{\mathrm{O}}_{3}$ were studied using time-domain terahertz transmission spectroscopy and infrared reflection spectroscopy. Thanks to the high probing frequency, the overall increase in the conductivity during the insulator to metal transition was observed both in the ceramics and in the nanogranular films. The terahertz conductivity spectrum shows that the transition is not a simple cross-over between two states. As the charges become delocalized during the insulator to metal transition, a broad resonant mode corresponding to the eigenfrequency of the binding potential appears in the terahertz conductivity spectra in the ceramics, and it further softens as the metallic state prevails. This is interpreted as a consequence of the complexity of charge motion in a temperature-dependent energy landscape, changing dramatically from the tightly bound charges on atomic distance in the insulating phase to almost free charges in the metallic phase. This behavior is not directly observed in the nanogranular films as their nature introduces spectral signatures of an additional localization due to grain boundaries which obscure the pronounced effects observed in the bulk. Nevertheless fine spectral signatures accompanying the phase transition are still resolved. The insulator to metal transition is also accompanied by a weak softening of infrared-active phonon modes, which is related to the expansion of lattice parameters upon phase transition.

Strongyloidiasis in dogs, despite its uncertain zoonotic status, is potentially danger for dogs owners. It is considered that strongyloidiases characteristic for tropical and subtropical regions, but in recent years it is increasingly found in non-endemic countries. The aim. To determine the extent of the invasion, clinical signs and diagnostic methods of strongyloidiasis in dogs of different groups in Kyiv and Kyiv region. Materials and methods.A total of 364 dogs were studied (130 animals lived in shelters (Group 1) and 234 in homes (Group 2). Diagnosis of strongyloidiasis was performed by native smear and Baerman methods. Additionally, the sensitivity of the modified string test was tested. Samples of venous blood were taken from dogs with confirmed strongyloidiasis for haematological and biochemical analysis. Results.A study found that the extent of invasion (EI) in shelters and home dogs was 3.0±0.36 %(4/130; Group 1) and 2.5±0.25 %% (6/234; Group 2) respectively. It was found that three repetitions of the Baerman method test increased its efficiency to 90.5 %. The sensitivity of the modified string test was 100 %. Clinical manifestations included disorders of the respiratory (20 %: 2/10) and digestive systems (80 %: 8/10), weight loss (70 %: 7/10). Blood tests did not reveal changes specific to strongyloidiasis, eosinophilia was observed in only one dog in the acute stage of the disease. Conclusions.The results of our studies indicate the presence of strongyloidiasis in dogs in Kyiv and Kyiv region and probability of the spread of the pathogen in the environment. Symptoms in dogs with strongyloidiasis were nonspecific and cannot be used for diagnosis. A modified string test and Baerman method has demonstrated high efficacy and may be recommended to clarify the diagnosis of a chronic invasion.

Results of an experimental study of the oxygen permeability of a PET film with nanosized aluminum oxide layers formed by reactive magnetron sputtering have been described. An experimental dependence of the oxygen permeability coefficient of PET film with the aluminum oxide layer in the range of 20 ÷ 80 nm, providing its value up to 1 cm3/(m2∙24h∙0.1MPa), have been determined. The effect of various factors on the formation of a high-quality reproducible oxide PET film and the characteristics of a nanosized aluminum oxide layer and the specific electric energy consumption for the magnetron deposition of the layer has been defined. The planar surface structures and surface roughness parameters of PET and oxide films with layers of different thicknesses have been determined. A qualitative interpretation of the results has been given.

Modern diagnostic of oncological diseases, along with classical clinical and morphological methods, provides for the mandatory use of instrumental immunological, immunocytochemical and molecular genetic research methods. The main tasks of such a complex of diagnostic measures are aimed at monitoring oncological diseases at all stages of the diagnostic and treatment process, namely: the detection of a tumor at early stages of its development and the study of changes in metabolic processes in the body under the influence of neoplasms, morphological confirmation of the diagnosis, identification of histostructure and histogenesis of the tumor, determination the degree of its malignancy, detection of metastatic lesion (regional and distant lymph nodes and other organs) or assessment of the risk of its occurrence. It is well know that the early stages of oncological diseases are difficult to diagnose. At the same time, early detection of the disease can save or significantly extend the life of the patient. In such cases, the determination in the blood of specific substances, which are produced by tumors of the respective organs, the so-called oncomarkers, has been successfully used by world medical practice for more than 40 years to establish the affected organ. In combination with instrumental methods (ultrasound, endoscopy, X-ray), diagnostic efficiency is sharply increasing. Successful treatment of malignant tumors is possible under the conditions of their early detection and thorough histological diagnosis. Almost 50 % of the total number of oncologically diseased dogs has tumorous processes in the tissues of their genital organs, aggressiveness and metastasis, which often leads to lethal consequences, even after radical interventions. The aim of our research was to study the histological, cytological and immunohistochemical characteristics of transmissible venereal sarcoma. It has be en established that histologically, the tumor belongs to the low-differentiated round-cellular sarcoma of the alveolar type. Typical is tumor infiltration by lymphocytes, plasma cells, macrophages. Tumor cells are characterized by the presence of a mesenchymal marker vimentine. A positive local reaction on myogenin, cytokeratin and negative on CD31, CD34, S-100 protein and desmin was observed.

The article describes occurrence and distribution of Eustrongylides trematodes in fish in the waters of the Dnipro-Buh estuary and the delta of Dnipro River in Mykolaiv and Kherson Region. Study was conducted in 2015–2016. This parasite was found in natural water reservoirs in Mykolaiv and Kherson region in following fish species: Sander lucioperca (Linnaeus, 1758), Perca fluviatilis (Linnaeus, 1758) and Esox lucius (Linnaeus, 1758). Ichtyopathological investigation of 346 fishes was conducted. Parasites were observed in abdominal cavity, muscle tissue, wall of gastro-intestinal tract, gonads and hepatopancreas. P. fluviatilis was the most affected species, prevalence of infection was 85.1 %. Less infected were S. lucioperca and E. lucius, with the prevalence of infection 58.1 % and 58.9 % respectively. Mean prevalence of infection of predatory fish in studied reservoirs was 70.5 %. The intensity of infection was the highest in perch (1–14 nematodes per fish). The lowest intensity of infection was found in pike-perch (1–9 nematodes per fish).

The article describes occurrence and distribution of Cryptocotyle trematodes in fish in the waters of the Dnipro-Buh estuary and the Black Sea in Mykolaiv and Odesa Region. Study was conducted in 2015-2016. Two trematode species were found in natural waters of these regions: Cryptocotyle cancavum Crepli, 1825 and Cryptocotyle jejuna Nicoll, 1907. Th e latter species has not been previously registered in this region in southern Ukraine. Varying intensity of infection with Cryptocotyle metacercariae was observed in fish of Gobiidae family: Mesogobius batrachocephalus Pallas, 1814, Neogobius melanostomum Pallas, 1814, N. fluviatialis Pallas, 1814. Th e most affected species was N. melanostomum, with the prevalence of infection 59.2 %. Less infected were N. fluviatialis and M. batrachocephalus, with the prevalence of infection 30.4 % and 17 % respectively. The intensity of infection was the highest in N. melanostomum - 211 metacercariae per fish, followed by N. fluviatialis and M. batrachocephalu - 124 and 89 metacercariae respectively. Cryptocotyle was the most prevalent in the Dnipro-Buh estuary (cape Adzhigol, Mykolaiv Region) and much less prevalent in the waters of the Black Sea in Mykolaiv and Odesa Regions. Mean prevalence of infection was 31.4 %.

A comparison of the mitochondrial haplotypes and conchological characteristics of shells made for the first time for two species of anodontin freshwater bivalves from the Asian genus Sinanodonta (S. amurensis and S. primorjensis) has confirmed a similarity of these two taxa. It was shown on the basis of statistical analysis that the discussed taxa possess similar shells and similar genetic haplotypes, and the observed differences in DNA sequences of cox1 and shells relate to intraspecific genetic and geographical variation.

The results of identification of Eimeria spp. oocysts based on fecal examination of cattle of the first year of life from 7 farms of Zhytomyr and Kyiv regions of Ukraine are presented in article. Nine species of Eimeria, namely, Eimeria zuernii (Rivolta, 1878) Martin, 1909; E. bovis (Zublin, 1908) Fiebiger, 1912; E. ellipsoidalis Becker and Frye, 1929; E. bukidnonensis Tubangui, 1931; E. cylindrica Wilson, 1931; E. canadensis Bruce, 1921; E. auburnensis Christensen and Porter, 1939; E. brasiliensis Torres and Ramos, 1939; E. wyomingensis Huizinga and Winger, 1942 were identified. Species of E. canadensis, E. auburnensis, E. brasiliensis and E. wyomingensis were found in calves for the first time in Ukraine.

The article presents the experience of using information and communication technologies and simulators in training future specialists in navigation and ship handling in maritime institutions of higher education. During the research a wide range of information and communication technologies and training tools were used in order to simulate scenarios of professional activity, emergency situations that are as close as possible to real conditions. The study was conducted from May 2015 to May 2019. The academic disciplines were enriched with separate components of simulator-based training for developing skills to work with electronic mapping systems, radio and electronic navigation equipment of ships, as well as skills related to maritime safety. Academic disciplines were delivered both in specialized laboratories equipped with the necessary training equipment and information and communication technologies in accordance with international requirements for training of marine specialists and the employers’ requirements, and also the training process included e-learning technologies. Comparison of research data before and after the experiment indicates a positive impact of information and communication technologies and simulators on the quality of training future specialists in navigation and ship handling.

W kamieniołomie położonym na południowo-zachodnim skraju Kazimierza Dolnego (Małopolski Przełom Wisły) oceniono fitosocjologicznie (metodą Braun-Blanqueta) i syntaksonomicznie występujące tam zbiorowiska roślinne. Na wyznaczonych powierzchniach zidentyfikowano 100 gatunków roślin, w tym 3 gatunki mchów. Wśród syntaksonomicznych jednostek roślinności zidentyfikowano 3 zespoły uformowane w różnych wariantach oraz 2 zbiorowiska roślinności, identyfikowane na poziomie wyższych jednostek syntaksonomicznych. Formowanie się zbiorowisk roślinnych w kamieniołomie zależało od ekspozycji stoku, jego nachylenia, położenia próby w odniesieniu do podnóża ściany kamieniołomu oraz składu mechanicznego podłoża, który kształtuje się w zależności od sposobu pozyskiwania kamienia

Thin film of two thermoelectric materials, Na x CoO 2 ( x ~ 0.6) and Ca 3 Co 4 O 9 , was deposited using the sol–gel spin-coating method on a polycrystalline yttria-stabilized zirconia (YSZ) substrate. Despite the polycrystalline character of the substrate, the c -axis preferred orientation was obtained, suggesting self-assembly growth mechanism. The deposition procedure used offers several benefits, namely simplicity, high deposition rate, low fabrication cost as well as low price of the substrate, and low thermal conductivity of the substrate suitable for characterization of thermoelectric properties and for applications. The thermoelectric properties of the thin films are comparable with bulk materials. The samples exhibit power factor 0.23 - 0.26 × 10 -3 W ⋅ m -1 ⋅ K -2 at 750 K.

plots which represent mixed oak stands of the Eastern Polissya of Ukraine, we have conducted an assessment and analysis of periodic and current increment of crown branches of oak trees by individual components as a basis for development of normative and information support for assessment of biotic productivity of this category of forests. A special technique was developed in order to study periodic and current increment of crown branches of oak trees by the main mensurational indices within three layers of crown - bottom, middle and top. To perform a study of increment of crown branches of oak trees by individual components, 20 model trees were cut down, 56 model branches were selected and measured. Model branches were grouped according to certain intervals of beginning and ending boundaries of the lower, middle and apical part of crown. After grouping, it was found that there were 23 branches from lower parts of crowns, 19 – from middle, and 10 branches – from apical parts of crowns. There was a separate study of increments of vertexes of model branches (20 pcs.). All model trees have different age and different mensurational parameters. Age of model trees ranges from 6 to 105 years; diameter at breast height – from 2,4 to 50,5 cm; height – from 3,4 to 31,5 m, average diameter of crown – from 1,1 to 10,0 m, length of crown – from 2,6 to 18,7 m, weight of tree greenery – from 0,2 to 160,4 kg, weight of branches – from 0,2 to 619,6 kg. It is found that the periodic increment of crown branches by diameter at zero section and length in various parts of crown depending on tree age and age of model branches have different pattern of change. In lower and middle part of crown with increasing crown length, and with increasing branch linkage height, periodical increment by diameter has an increasing trend, while in apical part of crown it has a decreasing tendency. It was also found that the highest values of current increment of crown branches of oak trees are observed in middle part of crown at tree age up to 20 years. The collected experimental data, their statistical and graph-analytical evaluation yielded information basis for modeling the periodic and current increment parameters of tree crown branches and stands of oak, which builds up a basis for forecasting volumes and rates of carbon accumulation in this category of stands.

The possibility of sustaining a quasi-stationary pulse-periodic optical discharge (POD) in xenon at a pressure of p = 10–20 bar in a focused 1.07-μm Yb3+ laser beam with a pulse repetition rate of f rep ⩾ 2 kHz, pulse duration of τ ⩾ 200 μs, and power of P = 200–300 W has been demonstrated. In the plasma development phase, the POD pulse brightness is generally several times higher than the stationary brightness of a continuous optical discharge at the same laser power, which indicates a higher plasma temperature in the POD regime. Upon termination of the laser pulse, plasma recombines and is then reinitiated in the next pulse. The initial absorption of laser radiation in successive POD pulses is provided by 5p 56s excited states of xenon atoms. This kind of discharge can be applied in plasma-based high-brightness broadband light sources.

Spin Seebeck effect (SSE) has been investigated in thin films of two Y-hexagonal ferrites Ba$_2$Zn$_{2}$Fe$_{12}$O$_{22}$ (Zn2Y) and Ba$_2$Co$_{2}$Fe$_{12}$O$_{22}$ (Co2Y) deposited by a spin-coating method on SrTiO$_3$(111) substrate. The selected hexagonal ferrites are both ferrimagnetic with similar magnetic moments at room temperature and both exhibit easy magnetization plane normal to $c$-axis. Despite that, SSE signal was only observed for Zn2Y, whereas no significant SSE signal was detected for Co2Y. We tentatively explain this different behavior by a presence of two different magnetic ions in Co2Y, whose random distribution over octahedral sites interferes the long range ordering and enhances the Gilbert damping constant. The temperature dependence of SSE for Zn2Y was measured and analyzed with regard to the heat flux and temperature gradient relevant to the SSE signal., 7 pages, 9 figures

The study evaluated weed infestation of pea (Pisum sativum L.) cultivated under conditions of conventional (CT), reduced (RT) and herbicide tillage (HT). It demonstrated the highest weed density per m2 in plots with the herbicide (HT) and reduced (RT) systems and significantly lower weed infestation in plots cultivated in the conventional system (CT). In addition, more weeds occurred at the third leaf stage (13/14 in BBCH scale) than at the pod development stage (73/74 BBCH) of pea. The highest biomass was produced by weeds in the herbicide system (HT), a lower one – in the reduced system (RT), and the lowest one – in the conventional system (CT). The air-dry weight of weeds depended also on pea development stage. At the pod development stage (73/74 BBCH), the air-dry weight of weeds was significantly higher than at the third leaf stage (13/14 BBCH). The tillage system was also observed to influence the species composition of weeds. This trait was also affected by the period of weed infestation assessment. At the third leaf stage of pea (13/14 BBCH), there occurred 26 weed species, including 24 annual ones. The most abundant species included: Chenopodium album L., Stellaria media (L.) Vill., Capsella bursa-pastoris (L.) Med., Matricaria inodora L., Thlaspi arvense L., and Fallopia convolvulus (L.) A. Löve. At the pod development stage (73/74 BBCH), the pea crop was colonized by 24 weed species, including 3 perennial ones. At this stage the predominant species included: Avena fatua L., Amaranthus retroflexus L., Papaver rhoeas L., Echinochloa crus-galli (L.) P.B., Matricaria inodora L., and Galeopsis tetrahit L.

The results of the experimental and theoretical investigations aimed at determining the characteristics and features of precision slot cutting with a large number of calibers in sheets of low-carbon steel using the radiation of a single-mode fiber laser with pulse power up to 1 kW are presented. The description of the experimental installation, performance conditions of investigations, and variable parameters are described. Precision cutting of low-carbon steel up to 10 mm with the number of calibers ranging from 30 to 70 at a slot width of ≈60 μm is performed for the first time. Such cutting occurs only in the pulsed-periodic mode using single-mode radiation with a pulse duration of 2–3 ms, a pulse ratio of 2–4, and oxygen, whose influence differs in principle both in various cut regions over the sheet thickness and from cutting with a CO2 laser. The cutting velocity (100–50 mm/min) of sheet steel up to thicknesses of 10 mm with deep channeling, roughness parameters, hardness of the cut surface, which insignificantly (by ≈20%) exceeds the hardness of untreated steel, the phase structure of steel, and the scales of their varying inside metal are measured. The efficiency (≈3%) of precision cutting and the efficiency of transportation of radiation (25%) in large-caliber slot orifices in the “waveguide” mode are determined by the experimental data. The useful specific energy contribution of the laser radiation is wl = Nl/(hbv) ≈ 2 × 1012 J/m2 for all studied thicknesses of sheet samples accurate to 20%. A qualitative model of the laser-oxygen precision cutting with deep channeling, which explains the cyclic and interrupting character of cutting and necessity of using oxygen as the cutting gas, is proposed.