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The study aims to calculate the technical and economic efficiency of adding hydrogen to natural gas to improve the energy characteristic of the fuel in gas-turbine plants during long-term gas field operations. Mathematical modelling techniques in the CAS CFDPT (computer-aided system for computational fluid dynamics of power turbomachinery) program were used to develop a mathematical model of the General Electric 6FA gas turbine engine. It was shown that a decrease in the calorific value of the fuel leads to an increase in fuel consumption by 11% and the amount of CO2, NO2 in the turbine exhaust gas. It was determined that, during the freezing season and peak power rating operations, the turbine power is limited by the fuel system capacity (its maximum value amounted to 5.04 kg/s). It was shown that energy characteristics can be improved by adding hydrogen to the feed natural gas. Energy efficiency was calculated at different fuel components (hydrogen and natural gas) ratios at variable-load operation in the range between 75 and 85 MW. Instant fuel gas flow amounted to 5.04 kg/s (with 4.5% hydrogen and 95.5% natural gas in the feed fuel) at 85 MW. Due to its high cost, the use of hydrogen is only advisable in peak power rating operations to reach the maximum capacity of the gas-turbine plant. The proposed method of adding 4.5% hydrogen to fuel gas allows the maximum fuel consumption to be maintained at a rate of 5.04 kg/s to reach the topping power of 85 MW. When using this method, there are no limitations on the maximum and peak capacity of the gas-turbine plant.

The obtaining of gas turbine engine mathematical models from experimental data with identification or refinement of their unit characteristics and the use of such models in parametric diagnostics methods is considered. The solution of improperly posed problems, where the number of equations is not equal to the number of unknowns, is proposed to be solved by a mathematical method specially developed using the stability of estimates.

Polyomaviruses are a family of ubiquitous double-stranded DNA viruses many of which are human pathogens. These include BK polyomavirus which causes severe urinary tract infection in immunocompromised patients and Merkel cell polyomavirus associated with aggressive cancers. The small genome of polyomaviruses lacks conventional drug targets, and no specific drugs are available at present. Here we focus on the main structural protein VP1 of BK polyomavirus which is responsible for icosahedral capsid formation. To provide a foundation towards rational drug design, we crystallized truncated VP1 pentamers and subjected them to a high-throughput screening for binding drug-like fragments through a direct X-ray analysis. To enable a highly performant screening, rigorous optimization of the crystallographic pipeline and processing with the latest generation PanDDA2 software were necessary. As a result, a total of 144 binding hits were established. Importantly, the hits are well clustered in six surface pockets. Three pockets are located on the outside of the pentamer and map on the regions where the ‘invading’ C-terminal arm of another pentamer is attached upon capsid assembly. Another set of three pockets is situated within the wide pore along the five-fold axis of the VP1 pentamer. These pockets are situated at the interaction interface with the minor capsid protein VP2 which is indispensable for normal functioning of the virus. Here we systematically analyse the three outside pockets which are highly conserved across various polyomaviruses, while point mutations in these pockets are detrimental for viral replication. We show that one of the pockets can accommodate antipsychotic drug trifluoperazine. For each pocket, we derive pharmacophore features which enable the design of small molecules preventing the interaction between VP1 pentamers and therefore inhibiting capsid assembly. Our data lay a foundation towards a rational development of first-in-class drugs targeting polyomavirus capsid. ispartof: RSC CHEMICAL BIOLOGY vol:3 issue:8 ispartof: location:England status: Published online

Purpose: To assess the contribution of low doses of diagnostic radiation due to computed tomography to carcinogenic risk among population of Ozersk. Material and methods: The study describes the results of the analysis of data from the radiation-epidemiological register created in the laboratory of radiation epidemiology of the Southern Urals Biophysics Institute of Ozersk. The register contains information on 26,626 CT examinations of Ozersk residents of all age groups, including children under 1 year old, carried out in medical departments of the Chelyabinsk region during the period from 1993 to 2018. Results: Based on the analyzed medical and dosimetric information from the CT Register database, the chances of malignant neoplasms among patients exposed to diagnostic irradiation during computed tomography were assessed taking into account the presence of the main radiation and non-radiation factors (age, sex, occupational exposure, number of CT examinations, effective dose and DLP). Conclusion: In a cohort of Ozersk residents who were exposed to low doses of diagnostic radiation during computed tomography, a statistically significant effect of sex and age attained to malignant neoplasm was obtained. Also, a significant relationship was found between the effective dose from diagnostic CT and the likelihood of subsequent cancer development diagnosed no earlier than 2 years after the first CT examination. At the same time, the DLP did not statistically significantly increase the chances of developing a malignant neoplasm in the study cohort for both the population and the personnel of the Mayak PA.

An analysis is carried out to estimate features of the atmospheric centers of action (ACA) in the Northern and Southern hemispheres using different long-term reanalysis data. The variability of ACAs and their relation to the hemispheric temperature and key climatic modes, including the El Nino–Southern Oscillation, Atlantic Multidecadal Oscillation, and Pacific Decadal Oscillation is analyzed. According to long-term data, it is found that the centennial hemispheric warming is accompanied by a significant weakening of the polar highs and the Greenland High that is more significant in summer. The deepening of the Icelandic Low, especially in summer, and the Aleutian Low, especially in winter, is shown. A significant weakening of the winter Siberian and North American highs and a deepening of the summer North American Low are also revealed. In the Southern Hemisphere, all three subpolar oceanic lows and the Mascarene High significantly intensify under warming conditions, while the summer Australian and South African lows weaken.

We report on the results of hybrid simulation of diffusive shock acceleration of ions with different charge-to-mass ratios in quasi-parallel collisionless shocks. We consider a hydrogen medium with dynamically insignificant admixtures of helium and carbon ions in various charge states. Spatial regions of applicability of the Bohm approximation as well as the quasi-linear diffusion theory are determined. The possibility of nondiffusive propagation in regions far ahead of the shock is considered.

The article considers the metaphors of “paper wave,” “paper pressing” and “paper genocide” as reflecting the social realities of the Russian education system, which are nonetheless poorly understood in sociolinguistics and mostly tabooed within respectable Russian academia and top-management. The relevancy and applicability of these metaphors are substantiated as their criteria, social contexts, and basic connotations are specified. “Paper genocide” is analyzed in journalistic and academic contexts as a term that reproduces the most significant aspects of genocide but with a social and non-criminal meaning. “Paper genocide” helps draw attention to the most acute social and managerial problem, a deadlock within the contemporary Russian education system.

Mycothiol (MSH), the major cellular thiol in Mycobacterium tuberculosis (Mtb), plays an essential role in the resistance of Mtb to various antibiotics and oxidative stresses. MshC catalyzes the ATP-dependent ligation of 1-O-(2-amino-2-deoxy-α-d-glucopyranosyl)-d-myo-inositol (GlcN-Ins) with l-cysteine (l-Cys) to form l-Cys-GlcN-Ins, the penultimate step in MSH biosynthesis. The inhibition of MshC is lethal to Mtb. In the present study, five new cysteinyl-sulfonamides were synthesized, and their binding affinity with MshC was evaluated using a thermal shift assay. Two of them bind the target with EC50 values of 219 and 231 µM. Crystal structures of full-length MshC in complex with these two compounds showed that they were bound in the catalytic site of MshC, inducing dramatic conformational changes of the catalytic site compared to the apo form. In particular, the observed closure of the KMSKS loop was not detected in the published cysteinyl-sulfamoyl adenosine-bound structure, the latter likely due to trypsin treatment. Despite the confirmed binding to MshC, the compounds did not suppress Mtb culture growth, which might be explained by the lack of adequate cellular uptake. Taken together, these novel cysteinyl-sulfonamide MshC inhibitors and newly reported full-length apo and ligand-bound MshC structures provide a promising starting point for the further development of novel anti-tubercular drugs targeting MshC. ispartof: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES vol:23 issue:23 ispartof: location:Switzerland status: published

Amphipathic nucleoside and non-nucleoside derivatives of pentacyclic aromatic hydrocarbon perylene are known as potent non-cytotoxic broad-spectrum antivirals. Here we report 3-methyl-5-(perylen-3-ylethynyl)-uracil-1-acetic acid and its amides, a new series of compounds based on a 5-(perylen-3-ylethynyl)-uracil scaffold. The compounds demonstrate pronounced in vitro activity against arthropod-borne viruses, namely tick-borne encephalitis virus (TBEV) and yellow fever virus (YFV), in plaque reduction assays with EC

An excess of 22Ne/20Ne in the isotopic composition of cosmic rays was discovered more than 40 years ago. Isotopic ratio 22Ne/20Ne measured in cosmic rays is more than five times higher than in the solar wind. It was proposed that processes in Wolf–Rayet stars were possible sources of this anomaly. Processes of the acceleration of cosmic rays in massive clusters of young stars containing WR populations are considered potential sources of galactic cosmic rays rich in 22Ne. Estimates of the share of cosmic rays generated by these sources are shown to satisfy the ratio 22Ne/20Ne observed experimentally.

A nonlinear Monte Carlo model is presented in which the spectra of accelerated particles and magnetic fluctuations are calculated self-consistently, allowing for nonlinear effects and plasma instabilities in the vicinity of a strong shock wave. Different model modes of particle scattering are considered. It is shown that the spectrum of accelerated particles is smoothed considerably when using the generalized mode of small-scale scattering instead of Bohm’s law of scattering.

New economy - an innovative economy - forms new challenges and new solutions in all spheres of human activity. A key feature of the new economic ties is their global nature. Transport systems based on existing technologies cannot provide the necessary growth of new economic ties and the effective provision of the existing business. New transport systems based on new technologies for transporting goods and passengers in compliance with the principles of energy and financial efficiency, as well as environmental safety, create the foundation for sustainable development of countries and regions, including improving the quality of life of the population and human potential. The rapid speed economic is been formed for nowadays commercial transportation communication. And a realization of any transport project has always tight connection and mutually conditioned with another project type energetics. So, the problem of energy efficiency and energy supply becomes a key factor of a choice of the most energy efficiency of a base system in any transport complex! Aim: The purpose of this article is to provide an alternative solution - the Integrated transit transport system (ITTS) of the Russian Federation based on the energy save technologies of Vacuum magnetic levitation transport (VMLT). Methods: The article discusses organizational, technical, energy efficient, logistic and economic solutions in the field of high-speed land corridors and "energy pipelines" projects, created on the basis of the latest vacuum magnetic levitation transport (VMLT) technologies. Experimental stands used are described, an overview of practical results obtained in laboratory and production equipment, and preliminary results of VMLT prototypings based on a miniature route of rare-earth magnets and leviters based on ceramics from a high-temperature superconductor, possibilities, prospects and the first experimental results of development are presented. of the main critical elements of the WMLT technology. The paper describes the results of using modern additive manufacturing technologies (3d printing) to create a system model, microcryogenic systems, HTSC and REM "nitrogen" temperature levels to create trace elements and system models, with the ability to scale to the current full-size model of the next generation. Results: The presented calculations show the practical possibility of further development and implementation of this project, as well as its very high effectiveness compared to existing systems in terms of practical application, economic, manufacturing, energy efficiency and environmental safety.

The results of computational modeling of experiments with heating of a water-filled and dewatered system are reported. The aim of the experiments was to test the computational methods used to analyze accidents in RBMK spent fuel storage, which is an example of a system with low heat fluxes. The calculations were performed using the RELAP5 code and a model specially developed for analyzing such experiments. It is shown that the RELAP5 code with the Reflood option gives acceptable results, but for lack of a description of surface evaporation in the code water level reduction in the calculations starts with a delay (after water boils) and occurs faster than in the experiment. When surface evaporation is taken into account by means of Balter’s empirical relation, the time dependence of the water level coincides with the experimental dependence. The variation of temperature at the control points of the heater is also close to the experiment. The heating of a dewatered system is described well by both models. Heat transfer by radiation from the heater to the vessel walls and into the ambient environment plays the main role.

The results of experimental modeling of the warming of a low-heat-flux system are presented. The water level reduction rates are compared with the warming rates of the elements of the system at different warming power. The water evaporation rate of the considered system is determined. It is shown that in modeling the warming of water systems with heat sources it is important to take account of the heat of phase transition.

While the bulk of GeV–100 TeV cosmic rays (CRs) can be accelerated at the shock of the most common supernova remnants the problem of CR acceleration to and above the PeV regime is still an open issue. We give a brief discussion of the production of 100 PeV regime cosmic rays by supernovae in young compact clusters of massive stars. This implies a spatial and temporal correlation of the SNe in the cluster over $$\sim 10^7\,\hbox {year}$$ which may affect the high-energy CR anisotropy. Here, we discuss the temporal evolution of the dipole angular anisotropy of 300 PeV CR protons accelerated within young massive star clusters.

Flavocytochrome c sulfide dehydrogenase (FCC) is one of the central enzymes of the respiratory chain in sulfur-oxidizing bacteria. FCC catalyzes oxidation of sulfide and polysulfide ions to elemental sulfur accompanied by electron transfer to cytochrome c. The catalytically active form of the enzyme is a non-covalently linked heterodimer composed of flavin- and heme-binding subunits. The Thioalkalivibrio paradoxus ARh1 genome contains five copies of genes encoding homologous FCCs with an amino acid sequence identity from 36 to 54%. When growing on thiocyanate or thiosulfate as the main energy source, the bacterium synthesizes products of different copies of FCC genes. In this work, we isolated and characterized FCC synthesized during the growth of Tv. paradoxus on thiocyanate. FCC was shown to oxidize exclusively sulfide but not other reduced sulfur compounds, such as thiosulfate, sulfite, tetrathionate, and sulfur, and it also does not catalyze the reverse reaction of sulfur reduction to sulfide. Kinetic parameters of the sulfide oxidation reaction are characterized.

We present results of spectral observations of two sunspots in six metal lines near Fe I 5434.5 Å, which have effective Lande factors g eff from – 0.014 to 2.14. The observations were made on July 8 and August 25, 2015, with the ATsU-5 telescope of GAO NAS of Ukraine using a circular polarization analyzer and spectra registration with the SBIG ST-8300 CCD camera. The following line parameters are compared: observed splitting of I ± V profiles, the width and depth of the Stokes I profiles. Significant differences of the measured magnetic field strengths B eff were found in separate places of the spots and by lines with different g eff values. The Fe I 5434.5 Ǻ line (g eff = –0.014) shows measurable splitting in some locations of the sunspots, which corresponds to the magnetic field B obs ≈ 20 kG. Comparison of the widths and depths of the line profiles revealed several special places in the sunspots, where the Fe I 5434.5 Ǻ line was expanded additionally by ≈ 15–35%, whereas other lines with larger Lande factors did not have such a feature. One of the reasons for this expansion could be a sharp and local increase of turbulent velocities, but no active processes such as solar flares or significant Doppler flows were observed at these locations. A semi-empirical model constructed for the first sunspot by FeI 5434.5 line using inverse code with Tikhonov`s stabilizers shows an anomalous feature – the maximum of microturbulent velocities in the upper photosphere and the temperature minimum zone instead of the usual small increase of microturbulence at these heights. This may be the effect of very strong magnetic fields of mixed polarity or unresolved turbulent structures. As to first case, the estimated value of the magnetic field in such locations of sunspots is ~10 5 G, which requires additional careful verification.

The metabolism of sucrose is of crucial importance for life on Earth. In plants, enzymes called invertases split sucrose into glucose and fructose, contributing to the regulation of metabolic fluxes. Invertases differ in their localization and pH optimum. Acidic invertases present in plant cell walls and vacuoles belong to glycoside hydrolase family 32 (GH32) and have an all-β structure. In contrast, neutral invertases are located in the cytosol and organelles such as chloroplasts and mitochondria. These poorly understood enzymes are classified into a separate GH100 family. Recent crystal structures of the closely related neutral invertases InvA and InvB from the cyanobacterium Anabaena revealed a predominantly α-helical fold with unique features compared with other sucrose-metabolizing enzymes. Here, a neutral invertase (AtNIN2) from the model plant Arabidopsis thaliana was heterologously expressed, purified and crystallized. As a result, the first neutral invertase structure from a higher plant has been obtained at 3.4 Å resolution. The hexameric AtNIN2 structure is highly similar to that of InvA, pointing to high evolutionary conservation of neutral invertases. ispartof: Acta Crystallographica Section F: Structural Biology and Crystallization Communications vol:76 issue:Pt 3 pages:152-157 ispartof: location:United States status: published

The origin of cosmic rays is one of the most important questions in modern astrophysics. Leading world observatories are engaged in their search in our Galaxy and beyond. Current observations of bright sources of hard X-rays and gamma radiation require precise models of cosmic-ray accelerators and emission generation. Recent detection of astrophysical neutrinos with the energy exceeding 1015 eV achieved by the IceCube Neutrino Observatory and registration by the LOFAR observatory of the light cosmic-ray component at 1016–1017 eV have given rise to a wide discussion of whether its sources are galactic or extragalactic. H.E.S.S. observations of high-energy gamma-ray sources in compact massive clusters Westerlund 1 and Cl*1806-20 triggered a new search for the models of effective accelerators of high-energy cosmic rays, socalled galactic PeVatrons. In this paper, the properties of compact massive young stellar clusters as possible sources of cosmic rays, neutrinos, and gamma emission are discussed. We suppose that an expanding supernova remnant in a compact massive cluster is an effective cosmic-ray accelerator up to the energies of 1015 eV and beyond. Energy spectra of particles being accelerated in the system of colliding shocks generated by a supernova remnant interaction with nearby stellar winds have a broken power-law shape with a strong upturn around several teraelectronvolts and a cutoff energy at tens of petaelectronvolts. These sources provide the maximal emission flux at the maximal energies of the spectrum. Teraelectronvolt sources detected by H.E.S.S. could be related to supernova remnants in Westerlund 1 and Cl*1806-20 and be responsible for the 10% of the IceCube neutrino events. We have also shown that PeVatrons in the systems of colliding shocks can provide up to 80% of the light cosmic-ray component at the energies of 1016–1017 eV detected at the Earth.

We discuss a specific population of galactic PeVatrons which may be the main source of the galactic cosmic-ray (CR) component well above PeV energies. Supernovae in compact clusters of massive stars are proposed as powerful sources of CRs, neutrinos, and gamma-ray emission. Numerical simulations of non-linear Fermi acceleration at converging shock flows have revealed that these accelerators can provide very hard spectra of protons up to $10^{16}-10^{17}$ eV which is well above the "knee" in the all-particle CR spectrum at about $3\times10^{15}$ eV. We suggest that known supernova remnants interacting with stellar winds in the compact clusters of young massive stars Westerlund I and Cl*1806-20 can be associated with the sources of the TeV gamma-ray emission detected by H.E.S.S. and may be responsible for a fraction of the high-energy neutrinos detected with the IceCube observatory. A recent CR composition measurement with the LOFAR array has revealed a light-mass component possibly dominating the all-particle spectrum at energies around $10^{17}$ eV. Such a strong light component (mainly protons and helium) may require specific galactic CR sources such as supernovae interacting with compact clusters of massive stars in addition to isolated supernova remnants., Accepted for publication in Advances in Space Research May 2017

The approaches to integration of a high-pressure super-reaction turbine of an aircraft gas turbine engine and a gas-dynamic laser are considered.

New observations of high-energy cosmic rays (CRs), gamma-rays and neutrinos have caused an intense debate about their origin. Detection of the most powerful astrophysical neutrinos with E > 10 15 eV by IceCube and detection of the light composition of the CR spectrum above the ‘knee’ made by LOFAR frame have intensified the debate over whether the sources are galactic or extragalactic. H.E.S.S. observations of very high-energy gamma-emission from compact galactic stellar clusters Westerlund 1 and Cl*1806-20 are also important for developing a model for a galactic PeVatron. We argue that expanding young supernova (SN) shells in compact stellar clusters can be very efficient PeV CR accelerators. The energy spectrum of protons in such an accelerator is hard with a broad spectral upturn above TeV before a break at multi-PeV energies, providing a large energy flux in the high-energy end of the spectrum. The acceleration stage in the colliding shock flow lasts for a few hundred years after the supernova explosion producing high-energy CRs that escape the accelerator and diffuse through the ambient matter producing gamma-rays and neutrinos in inelastic interacions with the ambient matter. Known supernova remnants interacting with stellar winds in the compact clusters of young massive stars Westerlund I and Cl*1806-20 can be associated with the sources of the TeV regime gamma-emission detected by H.E.S.S. and can be responsible for a fraction of the high-energy neutrinos detected with the IceCube observatory. We argue that these high-energy CR accelerators may also provide the light CR galactic component detected by LOFAR.

Diffusive shock acceleration (DSA) is a very efficient mechanism of high energy particle acceleration in heliosphere, supernova remnants, stellar winds and gamma-ray bursts. We present microscopic simulation of particle injection and diffusive shock acceleration which is performed with 3D divergence-conserving second-order accurate hybrid code "Maximus". Hydrogen plasma with admixture of various heavy ions is considered. The injection process is found to start through shock reflection for both hydrogen and heavier ions. However, the reflection process depends on charge-to-mass ratio. While hydrogen ions reflection appears at shock ramp and is governed by the cross-shock potential, the reflection of ions with greater A=Z proceeds deeper down-stream via gyration in perpendicular magnetic field component. The heavy ions appear to inject into the DSA preferentially, but this chemical enhancement saturates with growing A=Z. The protons injection efficiency is estimated within various approaches, and it is shown that about 20% of initial flow energy goes into accelerated particles.

—Nonequilibrium distributions of cosmic rays accelerated by the Fermi mechanism are formed by multiple interactions with magnetic fluctuations in the upstream region of a collisionless shock. The shock ram pressure is transferred to accelerated cosmic rays, which may in turn amplify the magnetic turbulence. A short-wave plasma instability induced in the upstream region of a collisionless shock caused by the interaction between cosmic rays and the background plasma is discussed.

We present a self-consistent Monte Carlo model of particle acceleration by relativistic shock waves. The model includes the magnetic field amplification in the shock upstream by cosmic ray driven plasma instabilities. The parameters of the Monte Carlo model are obtained based on PIC calculations. We present the spectra of accelerated particles simulated in the frame of the model.

Radio observations revealed a presence of relativistic supernovae - a class of objects intermediate between the regular supernovae and gamma-ray bursts. The typical Lorentz-factors of plasma flows in relativistic radio-bright supernovae were estimated to be about 1.5. Mildly relativistic shocks in electron-ion plasmas are known to efficiently accelerate radio-emitting electrons if the shock is subluminous. The inclination angle of the velocity of subluminous shock to the ambient magnetic field should be below a critical angle which depends on the Mach number and the plasma magnetization parameter. In this paper we present particle-in-cell modeling of electron acceleration by mildly-relativistic collisionless shock of different obliquity in a plasma with ratio of the magnetic energy to the bulk kinetic energy σ ≈ 0.004 which is of interest for the relativistic supernovae modeling. It was shown earlier that a development of the ion scale Bell-type instability in electron-ion relativistic shock may have a strong influence on the electron injection and acceleration. In the time period of about 1500 ω p i − 1 (ωpi is the ion plasma frequency) after the shock initialization the magnetic field fluctuations generated by Bell’s instability may significantly decreases number of accelerated electrons even in a sub-luminous shock. We study here the evolution of the electron spectra of subluminous shocks of different obliquity. This is important to for modeling of synchrothron spectra from relativistic supernovae.

We consider a turbofan engine (TFE), where the turbine rotor blades of the low pressure turbine (LPT) are micro-Laval nozzles. We demonstrated the possibility of integrating the super jet turbine and a jet nozzle as a single binary system for the purpose of generation of powerful coherence radiation. We estimated the efficiency of the binary high pressure emitting system being a TFE part.

The contribution of dynamic and thermodynamic causes in changes of precipitation character in Northern Eurasia that is expressed in increase of convective and decrease of large-scale precipitation, is still undetermined. Here, we estimate influence of atmospheric circulation on various characteristics of convective and large-scale precipitation in Northern Eurasia using correlation and regression analyses. We estimate different measures for atmospheric circulation including frequency of cyclones and anticyclones, blocking duration, intensity of the main atmospheric centers of action. Correlation and regression analyses were carried out using nonparametric Mann-Kendall correlation and Theil-Sen estimator. We revealed local response of precipitation on circulation characteristics, which strength varies in space and time. For some regions and seasons, opposite responses for convective and large-scale precipitation were found. Therefore, changing character of precipitation over Northern Eurasia can partly be explained by dynamical factors. Nevertheless, the main reason for increase of convective and decrease of large-scale precipitation is presumably associated with thermodynamics factors, namely increase of surface air temperature and humidity that resulting in convective instability growth.

For most elements, the isotopic ratios seen in cosmic rays (CRs) are similar to those in the solar wind. The most important exception to this is $^{22}$Ne/$^{20}$Ne where the CR value is $\sim 5$ times that of the solar wind. According to most recent models of nucleosynthesis, a large amount of $^{22}\mathrm{Ne}$ is generated in Wolf-Rayet (WR) stars. In the winds of carbon sequence WR stars, i.e., WC stars, the isotopic ratio $^{22}\mathrm{Ne}$/$^{20}\mathrm{Ne}$ can be much larger than in the solar wind. Here, we consider CRs produced by $^{22}\mathrm{Ne}$-enriched WR winds in compact clusters of young massive stars like Westerlund~1. We assume that efficient CR acceleration in clusters occurs over the WR lifetime in an ensemble of shock waves from multiple massive star winds. We estimate the fraction of all Galactic CRs such sources may produce for a given set of parameters., 5 pages, 1 figure, accepted for publication in IOP Journal of Physics: Conf. Series