1,933 results on '"A. Llebaria"'
Search Results
2. A ‘double-edged’ role for type-5 metabotropic glutamate receptors in pain disclosed by light-sensitive drugs
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Serena Notartomaso, Nico Antenucci, Mariacristina Mazzitelli, Xavier Rovira, Serena Boccella, Flavia Ricciardi, Francesca Liberatore, Xavier Gomez-Santacana, Tiziana Imbriglio, Milena Cannella, Charleine Zussy, Livio Luongo, Sabatino Maione, Cyril Goudet, Giuseppe Battaglia, Amadeu Llebaria, Ferdinando Nicoletti, and Volker Neugebauer
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photopharmacology ,pain ,behavior ,neuronal activity ,metabotropic glutamate receptor ,neurotransmission ,Medicine ,Science ,Biology (General) ,QH301-705.5 - Abstract
We used light-sensitive drugs to identify the brain region-specific role of mGlu5 metabotropic glutamate receptors in the control of pain. Optical activation of systemic JF-NP-26, a caged, normally inactive, negative allosteric modulator (NAM) of mGlu5 receptors, in cingulate, prelimbic, and infralimbic cortices and thalamus inhibited neuropathic pain hypersensitivity. Systemic treatment of alloswitch-1, an intrinsically active mGlu5 receptor NAM, caused analgesia, and the effect was reversed by light-induced drug inactivation in the prelimbic and infralimbic cortices, and thalamus. This demonstrates that mGlu5 receptor blockade in the medial prefrontal cortex and thalamus is both sufficient and necessary for the analgesic activity of mGlu5 receptor antagonists. Surprisingly, when the light was delivered in the basolateral amygdala, local activation of systemic JF-NP-26 reduced pain thresholds, whereas inactivation of alloswitch-1 enhanced analgesia. Electrophysiological analysis showed that alloswitch-1 increased excitatory synaptic responses in prelimbic pyramidal neurons evoked by stimulation of presumed BLA input, and decreased BLA-driven feedforward inhibition of amygdala output neurons. Both effects were reversed by optical silencing and reinstated by optical reactivation of alloswitch-1. These findings demonstrate for the first time that the action of mGlu5 receptors in the pain neuraxis is not homogenous, and suggest that blockade of mGlu5 receptors in the BLA may limit the overall analgesic activity of mGlu5 receptor antagonists. This could explain the suboptimal effect of mGlu5 NAMs on pain in human studies and validate photopharmacology as an important tool to determine ideal target sites for systemic drugs.
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- 2024
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3. Hemithioindigo-based histone deacetylase inhibitors induce a light-dependent anticancer effect
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Josa-Culleré, Laia, Aira Rodríguez, Carla, and Llebaria, Amadeu
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- 2024
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4. Observations of the Solar F-corona from Space
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Lamy, Philippe, Gilardy, Hugo, and Llebaria, Antoine
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Earth and Planetary Astrophysics - Abstract
The observations of the solar F-corona from space are reviewed emphasizing the 25 years of continuous monitoring achieved by the LASCO-C2 and C3 coronagraphs. Our work includes images obtained by the Clementine cameras, and the STEREO/SECCHI/HI-1A and PSP/WISPR heliospheric imagers. The characteristic radiance profiles along the equatorial and polar directions follow power laws in the 5{\deg}-50{\deg} range of elongation, with constant power exponents of -2.33 and -2.55. Both profiles connect extremely well to the corresponding standard profiles of the zodiacal light. The LASCO equatorial profile exhibits a shoulder implying a 17% decrease of the radiance within 10Rsun that may be explained by the disappearance of organic materials within 0.3 AU. LASCO detected for the first time a secular variation of the F-corona, an increase at a rate of 0.46% per year of the integrated radiance in the LASCO-C3 FoV. This is likely the first observational evidence of the role of collisions in the inner zodiacal cloud. A composite of C2 and C3 images produced the LASCO reference map of the radiance of the F-corona from 2 to 30Rsun and, by combining with ground-based measurements, the LASCO extended map from 1 to 6 Rsun. The plane of symmetry of the inner zodiacal cloud is strongly warped, its inclination increasing towards the planes of the inner planets and ultimately the solar equator. In contrast, its longitude of ascending node is found to be constant and equal to 87.6{\deg}. LASCO did not detect any small-scale structures such as putative rings occasionally reported during solar eclipses. The outer border of the depletion zone where interplanetary dust particles start to be affected by sublimation appears well constrained at 19Rsun. This zone extends down to 5Rsun, thus defining the boundary of the dust-free zone where the most refractory materials, likely moderately absorbing silicates, disappear., Comment: 85 pages, 42 figures, 5 tables
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- 2022
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5. Photoswitchable positive allosteric modulators of metabotropic glutamate receptor 4 to improve selectivity
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Silvia Panarello, Aleix González-Díez, Alice E. Berizzi, Fanny Malhaire, Roser Borràs-Tudurí, Xavier Rovira, Carme Serra, Laurent Prézeau, Jean-Philippe Pin, Cyril Goudet, Amadeu Llebaria, and Xavier Gómez-Santacana
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pharmacology ,natural sciences ,biological sciences ,Biochemistry ,molecular biology ,Science - Abstract
Summary: Metabotropic glutamate receptors (mGlu) regulate multiple functions in the nervous systems and are involved in several neurological disorders. However, selectively targeting individual mGlu subtypes with spatiotemporal precision is still an unmet need. Photopharmacology can address this concern through the utilization of photoswitchable compounds such as optogluram, which is a positive allosteric modulator (PAM) of mGlu4 that enables the precise control of physiological responses using light but does not have an optimal selectivity profile. Optogluram analogs were developed to obtain photoswitchable PAMs of mGlu4 receptor with an improved selectivity. Among them, optogluram-2 emerged as a photoswitchable ligand for mGlu4 receptor with activity as both PAM and allosteric agonists. It presents a higher selectivity and offers improved photoswitching of mGlu4 activity. These improved properties make optogluram-2 an excellent candidate to study the role of mGlu4 with a high spatiotemporal precision in systems where mGlu4 can be co-expressed with other mGlu receptors.
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- 2024
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6. Photoswitchable positive allosteric modulators of metabotropic glutamate receptor 4 to improve selectivity
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Panarello, Silvia, González-Díez, Aleix, Berizzi, Alice E., Malhaire, Fanny, Borràs-Tudurí, Roser, Rovira, Xavier, Serra, Carme, Prézeau, Laurent, Pin, Jean-Philippe, Goudet, Cyril, Llebaria, Amadeu, and Gómez-Santacana, Xavier
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- 2024
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7. Identification of differential biological activity and synergy between the PARP inhibitor rucaparib and its major metabolite
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Hu, Huabin, Serra, Carme, Zhang, Wenjie, Scrivo, Aurora, Fernández-Carasa, Irene, Consiglio, Antonella, Aytes, Alvaro, Pujana, Miguel Angel, Llebaria, Amadeu, and Antolin, Albert A.
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- 2024
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8. Are intracystic chromogranin A and neuron-specific enolase useful in the diagnosis of cystic pancreatic neuroendocrine tumors?
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Varas Lorenzo, Modesto J. and Puig, Carles Llebaria
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- 2024
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9. Restitution of the K and F Components of the Solar Corona from LASCO-C2 Images over 24 Years [1996--2019]
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Llebaria, Antoine, Lamy, Philippe, Gilardy, Hugo, Boclet, Brice, and Loirat, Jean
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Astrophysics - Solar and Stellar Astrophysics - Abstract
We present a photometrically accurate restitution of the K and F coronae from white-light images obtained over 24 Years [1996--2019] by the Large-Angle Spectrometric COronagraph "LASCO-C2" onboard the Solar and Heliospheric Observatory (SOHO). The procedure starts with the data set coming from the polarimetric separation of images of 512 x 512 pixels in which the F-corona and the instrumental stray light are entangled. Disentangling these components proceeds in three stages, each composed of several steps. Stage 1 establishes the distinct variations of the radiance of these components with the Sun--SOHO distance and generate a new data set of median images calculated for each Carrington rotation. Stage 2 achieves the restitution of a set of 36 stray light images reflecting its temporal variation and the periodic rolls of SOHO which started in 2003. Stage 3 achieves the restitution of the F-corona and a time series of daily images is generated. These results allowed us processing the whole set of routine LASCO-C2 images of 1024 x 1024 pixels (approximately 626000 images) and producing calibrated, high resolution images of the K-corona. We extend our past conclusions that the temporal variation of the integrated radiance of the K-corona tracks the solar activity over two solar cycles 23 and 24 and that it is highly correlated with the temporal variation of the total magnetic field. The behaviours of the integrated radiance during the last few years of the declining phases of solar cycles 23 and 24 are remarkably similar, reaching the same floor level and leading to a duration of 11.0 year for the latter cycle, in agreement with the sunspot determination., Comment: 1. Added two new Sections 3.5 and 4.2 discussing uncertainties, with new Figures (21 and 23); results unchanged. 2. Added a comparison with the results of Hayes et al. (2001) in Fig. 24
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- 2020
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10. Coronal Photopolarimetry with the LASCO-C3 Coronagraph over 24 Years [1996-2019] -- Application to the K/F Separation and to the Determination of the Electron Density
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Lamy, Philippe, Gilardy, Hugo, Llebaria, Antoine, Quemerais, Eric, and Ernandes, Fabrice
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Astrophysics - Solar and Stellar Astrophysics - Abstract
We present an in-depth characterization of the polarimetric channel of the Large-Angle Spectrometric COronagraph/LASCO-C3 onboard SOHO. The polarimetric analysis of the white-light images makes use of polarized sequences composed of three images obtained through three polarizers oriented at +60$^\circ$, 0$^\circ$, and -60$^\circ$, complemented by a neighboring unpolarized image. However, the degradation of the 0$^\circ$ polarizer noticed in 1999 compelled us to reconstruct the corresponding images from the other ones thereafter. The analysis closely follows the method developed for LASCO-C2 (Lamy, et al. Solar Physics 295, 89, 2020 and arXiv:2001.05925) and implements the formalism of Mueller, albeit with additional difficulties notably the presence of a non-axially symmetric component of stray light. Critical corrections were derived from a SOHO roll sequence and from consistency criteria (e.g., the tangential direction of polarization). The quasi-uninterrupted photopolarimetric analysis of the outer corona over two complete Solar Cycles 23 and 24 was successfully achieved and our final results encompass the characterization of its polarization, of its polarized radiance, of the two-dimensional electron density, and of the K-corona. Comparison between the C3 and C2 results where their field of view overlaps shows an overall agreement. The C3 results are further in agreement with those of eclipses and radio ranging measurements to an elongation of about 10 solar radii but tend to diverge further out. Whereas the coronal polarization out to 20 solar radii is still highly correlated with the temporal variation of the total magnetic field, this divergence probably results from the increasing polarization of the F-corona., Comment: 61 pages, 45 figures. arXiv admin note: text overlap with arXiv:2001.05925
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- 2020
11. PHOTOACTIVATION OF INDIVIDUAL SYNAPSES IN VIVO WITH COVALENT PHOTOSWITCHES TARGETING ENDOGENOUS GLUTAMATE RECEPTORS
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Aida Garrido-Charles, Miquel Bosch, Hyojung Lee, Xavier Rovira, Silvia Pittolo, Artur Llobet, Hovy Ho-Wai Wong, Ana Trapero, Carlo Matera, Claudio Papotto, Carme Serra, Amadeu Llebaria, Eduardo Soriano, Maria Sanchez-Vives, Christine Holt, and Pau Gorostiza
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Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Published
- 2023
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12. Mitochondria-targeted melatonin photorelease supports the presence of melatonin MT1 receptors in mitochondria inhibiting respiration
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Somalo-Barranco, Gloria, Pagano Zottola, Antonio C., Abdulrahman, Abdulrasheed O., El Zein, Rami M., Cannich, Astrid, Muñoz, Lourdes, Serra, Carme, Oishi, Atsuro, Marsicano, Giovanni, Masri, Bernard, Bellocchio, Luigi, Llebaria, Amadeu, and Jockers, Ralf
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- 2023
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13. The antioxidant l-Ergothioneine prevents cystine lithiasis in the Slc7a9−/− mouse model of cystinuria
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Mayayo-Vallverdú, Clara, López de Heredia, Miguel, Prat, Esther, González, Laura, Espino Guarch, Meritxell, Vilches, Clara, Muñoz, Lourdes, Asensi, Miguel A., Serra, Carmen, Llebaria, Amadeu, Casado, Mercedes, Artuch, Rafael, Garrabou, Gloria, Garcia-Roves, Pablo M., Pallardó, Federico V., and Nunes, Virginia
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- 2023
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14. The antioxidant l-Ergothioneine prevents cystine lithiasis in the Slc7a9−/− mouse model of cystinuria
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Clara Mayayo-Vallverdú, Miguel López de Heredia, Esther Prat, Laura González, Meritxell Espino Guarch, Clara Vilches, Lourdes Muñoz, Miguel A. Asensi, Carmen Serra, Amadeu Llebaria, Mercedes Casado, Rafael Artuch, Gloria Garrabou, Pablo M. Garcia-Roves, Federico V. Pallardó, and Virginia Nunes
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Cystinuria ,l-Ergothioneine ,Cystine lithiasis ,Antioxidant ,Oxidative stress ,Treatment ,Medicine (General) ,R5-920 ,Biology (General) ,QH301-705.5 - Abstract
The high recurrence rate of cystine lithiasis observed in cystinuria patients highlights the need for new therapeutic options to address this chronic disease. There is growing evidence of an antioxidant defect in cystinuria, which has led to test antioxidant molecules as new therapeutic approaches. In this study, the antioxidant l-Ergothioneine was evaluated, at two different doses, as a preventive and long-term treatment for cystinuria in the Slc7a9−/− mouse model. l-Ergothioneine treatments decreased the rate of stone formation by more than 60% and delayed its onset in those mice that still developed calculi. Although there were no differences in metabolic parameters or urinary cystine concentration between control and treated mice, cystine solubility was increased by 50% in the urines of treated mice. We also demonstrate that l-Ergothioneine needs to be internalized by its transporter OCTN1 (Slc22a4) to be effective, as when administrated to the double mutant Slc7a9−/−Slc22a4−/− mouse model, no effect on the lithiasis phenotype was observed. In kidneys, we detected a decrease in GSH levels and an impairment of maximal mitochondrial respiratory capacity in cystinuric mice that l-Ergothioneine treatment was able to restore. Thus, l-Ergothioneine administration prevented cystine lithiasis in the Slc7a9−/− mouse model by increasing urinary cystine solubility and recovered renal GSH metabolism and mitochondrial function. These results support the need for clinical trials to test l-Ergothioneine as a new treatment for cystinuria.
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- 2023
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15. Reversible silencing of endogenous receptors in intact brain tissue using 2-photon pharmacology
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Pittolo, Silvia, Lee, Hyojung, Lladó, Anna, Tosi, Sébastien, Bosch, Miquel, Bardia, Lídia, Gómez-Santacana, Xavier, Llebaria, Amadeu, Soriano, Eduardo, Colombelli, Julien, Poskanzer, Kira E, Perea, Gertrudis, and Gorostiza, Pau
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Neurosciences ,Underpinning research ,1.1 Normal biological development and functioning ,Neurological ,Animals ,Astrocytes ,Brain ,Calcium ,Neurons ,Optogenetics ,Photons ,Rats ,Rats ,Sprague-Dawley ,Receptor ,Metabotropic Glutamate 5 ,Receptors ,Cell Surface ,photopharmacology ,photoactivation ,pharmacological selectivity ,functional silencing ,2-photon pharmacology - Abstract
The physiological activity of proteins is often studied with loss-of-function genetic approaches, but the corresponding phenotypes develop slowly and can be confounding. Photopharmacology allows direct, fast, and reversible control of endogenous protein activity, with spatiotemporal resolution set by the illumination method. Here, we combine a photoswitchable allosteric modulator (alloswitch) and 2-photon excitation using pulsed near-infrared lasers to reversibly silence metabotropic glutamate 5 (mGlu5) receptor activity in intact brain tissue. Endogenous receptors can be photoactivated in neurons and astrocytes with pharmacological selectivity and with an axial resolution between 5 and 10 µm. Thus, 2-photon pharmacology using alloswitch allows investigating mGlu5-dependent processes in wild-type animals, including synaptic formation and plasticity, and signaling pathways from intracellular organelles.
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- 2019
16. Caged-carvedilol as a new tool for visible-light photopharmacology of β-adrenoceptors in native tissues
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Duran-Corbera, Anna, Font, Joan, Faria, Melissa, Prats, Eva, Consegal, Marta, Catena, Juanlo, Muñoz, Lourdes, Raldua, Demetrio, Rodriguez-Sinovas, Antonio, Llebaria, Amadeu, and Rovira, Xavier
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- 2022
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17. Photoswitchable allosteric modulators for metabotropic glutamate receptors
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Gómez-Santacana, Xavier, Panarello, Silvia, Rovira, Xavier, and Llebaria, Amadeu
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- 2022
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18. Get in Sync: Active Ingredients and Patient Profiles in Scripted-Sentence Learning in Spanish Speakers With Aphasia
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Quique, Yina M., Evans, William S., Ortega-Llebaria, Marta, Zipse, Lauryn, and Dickey, Michael Walsh
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Aphasia -- Risk factors -- Diagnosis -- Care and treatment ,Scripts (Psychology) -- Training ,Speech therapy -- Methods ,Evidence-based medicine -- Methods ,Health - Abstract
Purpose: Script training is a well-established treatment for aphasia, but its evidence comes almost exclusively from monolingual English speakers with aphasia. Furthermore, its active ingredients and profiles of people with aphasia (PWA) that respond to this treatment remain understudied. This study aimed to adapt a scripted-sentence learning protocol to Colombian Spanish speakers with aphasia, investigate speech entrainment (i.e., unison production of sentences) as an active ingredient for scripted-sentence learning, and identify patient profiles associated with better scripted-sentence learning. Method: Fourteen monolingual Spanish speakers with aphasia learned a set of 30 sentences. To examine speech entrainment as an active ingredient for scripted-sentence learning, we investigated whether sentences containing externally added rhythmic cues (involving stress-aligned vs. metronomic rhythmic cues) would result in better scripted-sentence learning compared with control sentences. Learning was measured via postsession probes and analyzed using mixed-effects logistic regression models. The relationship between scripted-sentence learning and baseline language and rhythmic processing measures was also examined. Results: Significant scripted-sentence learning over time indicated a successful adaptation of a script-training protocol to Spanish. PWA learned significantly more scripted sentences in the rhythmically enhanced conditions compared with the control condition. There were no differences between rhythmically enhanced conditions (stress-aligned vs. metronomic). In terms of patient profiles, it was found that PWA with more severe aphasia demonstrated larger learning gains, but rhythmic processing showed little association with learning estimates. Conclusions: To our knowledge, this study provides the first adaptation of a scripted-sentence learning protocol for monolingual Spanish speakers with aphasia, demonstrating cross-linguistic benefits of script training interventions. Highlighting rhythmic features during speech entrainment facilitated scripted-sentence learning in Spanish speakers with aphasia, suggesting that speech entrainment may be an active ingredient for scripted-sentence learning. More severe aphasia was associated with better scripted-sentence learning, suggesting that more severely impaired individuals are likely to benefit most from this treatment. Supplemental Material: https://doi.org/10.23641/asha.19241847, Understanding the connection between active ingredients and patient profiles associated with better response to evidence-based aphasia treatments is a necessary step to improve both the implementation and individualization of aphasia [...]
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- 2022
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19. Environmental levels of carbaryl impair zebrafish larvae behaviour: The potential role of ADRA2B and HTR2B
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Faria, Melissa, Bellot, Marina, Bedrossiantz, Juliette, Ramírez, Jonathan Ricardo Rosas, Prats, Eva, Garcia-Reyero, Natalia, Gomez-Canela, Cristian, Mestres, Jordi, Rovira, Xavier, Barata, Carlos, Oliván, Leobardo Manuel Gómez, Llebaria, Amadeu, and Raldua, Demetrio
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- 2022
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20. The VIPERS Multi-Lambda Survey. I. UV and NIR Observations, multi-color catalogues and photometric redshifts
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Moutard, T., Arnouts, S., Ilbert, O., Coupon, J., Hudelot, P., Vibert, D., Comte, V., Conseil, S., Davidzon, I., Guzzo, L., Llebaria, A., Martin, C., McCracken, H. J., Milliard, B., Morrison, G. E., Schiminovich, D., Treyer, M., and Van Werbaeke, L.
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Astrophysics - Astrophysics of Galaxies - Abstract
We present observations collected in the CFHTLS-VIPERS region in the ultraviolet (UV) with the GALEX satellite (far and near UV channels) and the near infrared with the CFHT/WIRCam camera ($K_s$-band) over an area of 22 and 27 deg$^2$, respectively. The depth of the photometry was optimized to measure the physical properties (e.g., SFR, stellar masses) of all the galaxies in the VIPERS spectroscopic survey. The large volume explored by VIPERS will enable a unique investigation of the relationship between the galaxy properties and their environment (density field and cosmic web) at high redshift (0.5 < z < 1.2). In this paper, we present the observations, the data reductions and the build-up of the multi-color catalogues. The CFHTLS-T0007 (gri-{\chi}^2) images are used as reference to detect and measure the $K_s$-band photometry, while the T0007 u-selected sources are used as priors to perform the GALEX photometry based on a dedicated software (EMphot). Our final sample reaches $NUV_{AB}$~25 (at 5{\sigma}) and $K_{AB}$~22 (at 3{\sigma}). The large spectroscopic sample (~51,000 spectroscopic redshifts) allows us to highlight the robustness of our star/galaxy separation, and the reliability of our photometric redshifts with a typical accuracy $\sigma_z \le$ 0.04 and a catastrophic failure rate {\eta} < 2% down to i~23. We present various tests on the $K_s$ band completeness and photometric redshift accuracy by comparing with existing, overlapping deep photometric catalogues. Finally, we discuss the BzK sample of passive and active galaxies at high redshift and the evolution of galaxy morphology in the (NUV-r) vs (r-K_s) diagram at low redshift (z < 0.25) thanks to the high image quality of the CFHTLS. The images, catalogues and photometric redshifts for 1.5 million sources (down to $NUV \le$ 25 or $K_s \le$ 22) are released and available at this URL: http://cesam.lam.fr/vipers-mls/, Comment: 14 pages, 16 figures. Accepted for publication in A&A. Version to be published
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- 2016
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21. Caged-carvedilol as a new tool for visible-light photopharmacology of β-adrenoceptors in native tissues
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Anna Duran-Corbera, Joan Font, Melissa Faria, Eva Prats, Marta Consegal, Juanlo Catena, Lourdes Muñoz, Demetrio Raldua, Antonio Rodriguez-Sinovas, Amadeu Llebaria, and Xavier Rovira
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Pharmacology ,Biological sciences ,Biochemistry ,Medical biochemistry ,Cell biology ,Biological sciences research methodologies ,Science - Abstract
Summary: Adrenoceptors are G protein-coupled receptors involved in a large variety of physiological processes, also under pathological conditions. This is due in large part to their ubiquitous expression in the body exerting numerous essential functions. Therefore, the possibility to control their activity with high spatial and temporal precision would constitute a valuable research tool. In this study, we present a caged version of the approved non-selective β-adrenoceptor antagonist carvedilol, synthesized by alkylation of its secondary amine with a coumarin derivative. Introducing this photo-removable group abolished carvedilol physiological effects in cell cultures, mouse isolated perfused hearts and living zebrafish larvae. Only after visible light application, carvedilol was released and the different physiological systems were pharmacologically modulated in a similar manner as the control drug. This research provides a new photopharmacological tool for a wide range of research applications that may help in the development of future precise therapies.
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- 2022
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22. Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations
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Nasrallah, Chady, Cannone, Giuseppe, Briot, Julie, Rottier, Karine, Berizzi, Alice E., Huang, Chia-Ying, Quast, Robert B., Hoh, Francois, Banères, Jean-Louis, Malhaire, Fanny, Berto, Ludovic, Dumazer, Anaëlle, Font-Ingles, Joan, Gómez-Santacana, Xavier, Catena, Juanlo, Kniazeff, Julie, Goudet, Cyril, Llebaria, Amadeu, Pin, Jean-Philippe, Vinothkumar, Kutti R., and Lebon, Guillaume
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- 2021
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23. Design and validation of a low-cost photomodulator for in vivo photoactivation of a mGluR5 inhibitor
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0000-0003-2308-0704, Ajieren, Hans, Fox, Andrew, Biggs, Ethan, Albors, Gabriel, Llebaria, Amadeu, Irazoqui, Pedro, 0000-0003-2308-0704, Ajieren, Hans, Fox, Andrew, Biggs, Ethan, Albors, Gabriel, Llebaria, Amadeu, and Irazoqui, Pedro
- Abstract
Purpose: Severe side effects prevent the utilization of otherwise promising drugs in treatments. These side effects arise when drugs affect untargeted tissues due to poor target specificity. In photopharmacology, light controls the timing and the location of drug delivery, improving treatment specificity and pharmacokinetic control. Photopharmaceuticals have not seen widespread adoption in part because researchers do not always have access to reliable and reproducible light delivery devices at prices which fit within the larger research budget. Method: In this work, we present a customizable photomodulator for use in both wearable and implantable devices. For experimental validation of the photomodulator, we photolyse JF-NP-26 in rats. Results: We successfully drive in vivo photopharmacology with a tethered photomodulator and demonstrate modifications which enable the photomodulator to operate wirelessly. Conclusion: By documenting our photomodulator development, we hope to introduce researchers to a simple solution which significantly lowers the engineering barriers to photopharmacology research.
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- 2024
24. Optical Control of Adenosine A2A Receptor Using Istradefylline Photosensitivity
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0000-0001-8830-0494, 0000-0002-8255-3535, Dumazer, Anaëlle, Gómez-Santacana, Xavier, Malhaire, Fanny, Jopling, Chris, Maurel, Damien, Lebon, Guillaume, Llebaria, Amadeu, Goudet, Cyril, 0000-0001-8830-0494, 0000-0002-8255-3535, Dumazer, Anaëlle, Gómez-Santacana, Xavier, Malhaire, Fanny, Jopling, Chris, Maurel, Damien, Lebon, Guillaume, Llebaria, Amadeu, and Goudet, Cyril
- Abstract
In recent years, there has been growing interest in the potential therapeutic use of inhibitors of adenosine A2A receptors (A2AR) for the treatment of neurodegenerative diseases and cancer. Nevertheless, the widespread expression of A2AR throughout the body emphasizes the importance of temporally and spatially selective ligands. Photopharmacology is an emerging strategy that utilizes photosensitive ligands to attain high spatiotemporal precision and regulate the function of biomolecules using light. In this study, we combined photochemistry and cellular and in vivo photopharmacology to investigate the light sensitivity of the FDA-approved antagonist istradefylline and its potential use as an A2AR photopharmacological tool. Our findings reveal that istradefylline exhibits rapid trans-to-cis isomerization under near-UV light, and prolonged exposure results in the formation of photocycloaddition products. We demonstrate that exposure to UV light triggers a time-dependent decrease in the antagonistic activity of istradefylline in A2AR-expressing cells and enables real-time optical control of A2AR signaling in living cells and zebrafish. Together, these data demonstrate that istradefylline is a photoinactivatable A2AR antagonist and that this property can be utilized to perform photopharmacological experiments in living cells and animals.
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- 2024
25. Photoswitchable positive allosteric modulators of metabotropic glutamate receptor 4 to improve selectivity
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European Commission, Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72], Panarello, Silvia, González-Díez, Aleix, Berizzi, Alice E., Malhaire, Fanny, Borràs-Tudurí, Roser, Rovira, Xavier, Serra, Carme, Prézeau, Laurent, Pin, Jean Philippe, Goudet, Cyril, Llebaria, Amadeu, Gómez-Santacana, Xavier, European Commission, Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72], Panarello, Silvia, González-Díez, Aleix, Berizzi, Alice E., Malhaire, Fanny, Borràs-Tudurí, Roser, Rovira, Xavier, Serra, Carme, Prézeau, Laurent, Pin, Jean Philippe, Goudet, Cyril, Llebaria, Amadeu, and Gómez-Santacana, Xavier
- Abstract
Metabotropic glutamate receptors (mGlu) regulate multiple functions in the nervous systems and are involved in several neurological disorders. However, selectively targeting individual mGlu subtypes with spatiotemporal precision is still an unmet need. Photopharmacology can address this concern through the utilization of photoswitchable compounds such as optogluram, which is a positive allosteric modulator (PAM) of mGlu4 that enables the precise control of physiological responses using light but does not have an optimal selectivity profile. Optogluram analogs were developed to obtain photoswitchable PAMs of mGlu4 receptor with an improved selectivity. Among them, optogluram-2 emerged as a photoswitchable ligand for mGlu4 receptor with activity as both PAM and allosteric agonists. It presents a higher selectivity and offers improved photoswitching of mGlu4 activity. These improved properties make optogluram-2 an excellent candidate to study the role of mGlu4 with a high spatiotemporal precision in systems where mGlu4 can be co-expressed with other mGlu receptors.
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- 2024
26. A ‘double-edged’ role for type-5 metabotropic glutamate receptors in pain disclosed by light-sensitive drugs.
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Notartomaso, Serena, Antenucci, Nico, Mazzitelli, Mariacristina, Rovira, Xavier, Boccella, Serena, Ricciardi, Flavia, Liberatore, Francesca, Gomez-Santacana, Xavier, Imbriglio, Tiziana, Cannella, Milena, Zussy, Charleine, Luongo, Livio, Maione, Sabatino, Goudet, Cyril, Battaglia, Giuseppe, Llebaria, Amadeu, Nicoletti, Ferdinando, and Neugebauer, Volker
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- 2024
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27. Modulation of Metabotropic Glutamate Receptors by Orthosteric, Allosteric, and Light-Operated Ligands
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Goudet, Cyril, Rovira, Xavier, Rondard, Philippe, Pin, Jean-Philippe, Llebaria, Amadeu, Acher, Francine, Bernstein, Peter R., Series Editor, Garner, Amanda L., Series Editor, Georg, Gunda I., Series Editor, Kobayashi, Toshi, Series Editor, Lowe, John A., Series Editor, Meanwell, Nicholas A., Series Editor, Saxena, Anil Kumar, Series Editor, Stilz, Ulrich, Series Editor, Supuran, Claudiu T., Series Editor, Zhang, Ao, Series Editor, and Lebon, Guillaume, editor
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- 2019
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28. A “double-edged” role for type-5 metabotropic glutamate receptors in pain disclosed by light-sensitive drugs
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Notartomaso, Serena, primary, Antenucci, Nico, additional, Mazzitelli, Mariacristina, additional, Rovira, Xavier, additional, Boccella, Serena, additional, Ricciardi, Flavia, additional, Liberatore, Francesca, additional, Gomez-Santacana, Xavier, additional, Imbriglio, Tiziana, additional, Cannella, Milena, additional, Zussy, Charleine, additional, Luongo, Livio, additional, Maione, Sabatino, additional, Goudet, Cyril, additional, Battaglia, Giuseppe, additional, Llebaria, Amadeu, additional, Nicoletti, Ferdinando, additional, and Neugebauer, Volker, additional
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- 2024
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29. Feeding injury of major lepidopteran soybean pests in South America
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Pablo Daniel Carpane, Matías Llebaria, Ana Flavia Nascimento, and Lucía Vivan
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Medicine ,Science - Abstract
Lepidopteran pests are major factors limiting soybean productivity in South America. In some cases, effective management of these species requires the use of foliar insecticides. For sustainable use of these insecticides, they should only be applied when insect population size exceeds an economic threshold. Since this estimation requires to determine the consumption of different species, this work aimed to integrate all these factors, studying the consumption of small (less than 1 cm long) and medium (1 to 1.5 cm long) size larvae of major lepidopteran pests to vegetative and reproductive tissues on Bt (M7739IPRO variety, containing the event MON87701 which expresses the Cry1Ac protein from Bacillus thuringiensis) and non-Bt (BMX Desafio RR variety) soybeans. The feeding injury to vegetative tissues was tested in detached-leaf assays in grow chambers, and for reproductive structures the study was conducted in greenhouse with infestations at early (flowering) and mid reproductive (mid grain filling) stages. Based on the feeding behavior of the species tested, they were cast in four groups: a) Anticarsia gemmatalis and Chrysodeixis includens, defoliating only the RR variety with the lowest consumption of foliar area; b) Spodoptera eridania, defoliating both RR and IPRO varieties, consuming twice than the species mentioned above; c) Helicoverpa armigera, defoliating and being the most damaging species to pods in the RR variety; and d) S. cosmioides and S. frugiperda, defoliating and damaging pods in both varieties. The species differed in their ability to feed on IPRO varieties, so a different economic threshold should be considered. Consequently, in cases where more than one species are found simultaneously, the species composition should be considered in estimating the economic threshold. Additionally, our findings may contribute to a better decision-making to control insect feeding injury in IPRO varieties, because a slower larval growth provides more time to ensure the need of control with insecticides. In summary, this clasification contributes to an improved recommendation of sustainable insecticide use, taking into account the behavior of each species that are major soybeans pests in South America.
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- 2022
30. Development and validation of a mass spectrometry binding assay for mGlu5 receptor
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Ricart-Ortega, Maria, Berizzi, Alice E., Catena, Juanlo, Malhaire, Fanny, Muñoz, Lourdes, Serra, Carmen, Lebon, Guillaume, Goudet, Cyril, and Llebaria, Amadeu
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- 2020
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31. Stress Typicality Effect in Chinese Advanced and Intermediate ESL Learners
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Zhang, Juan, Meng, Yaxuan, Fan, Xitao, Ortega-Llebaria, Marta, and Ieong, Sao Leng
- Abstract
In English, positions of lexical stress in disyllabic words are associated with word categories; that is, nouns tend to be stressed more often on the first syllable, whereas verbs are more likely to be stressed on the second syllable (i.e. "sub"ject (noun) vs. sub"ject" (verb)). This phenomenon, which is called the stress typicality effect, has been shown to facilitate word recognition to native English speakers. However, there is little research on whether it also facilitates word recognition to non-native speakers of English, in particular, to English learners with a tonal first language. To fill this research gap, the present study investigated whether the stress typicality effect modulated word recognition in native speakers of Chinese who learned English as a second language. Both visual grammatical classification and lexical decision tasks were administered to ESL learners with intermediate and advanced English proficiency. The results revealed that Chinese intermediate ESL learners were not sensitive to stress typicality in English; however, the advanced learners were. The findings suggest that different performances in stress assignment among Chinese ESL learners were influenced by their English proficiency levels.
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- 2018
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32. Do Proficient Mandarin Speakers of English Exhibit an Interlanguage–Speech Intelligibility Benefit When Tested with Complex Sound–Meaning Mapping Tasks?
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Ortega-Llebaria, Marta, primary, Chu, Claire C., additional, and Epp, Carrie Demmans, additional
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- 2021
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33. Control of Theta Oscillatory Activity Underlying Fear Expression by mGlu5 Receptors
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Pawel Matulewicz, Arnau Ramos-Prats, Xavier Gómez-Santacana, Amadeu Llebaria, and Francesco Ferraguti
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metabotropic glutamate receptors ,fear conditioning ,theta rhythm ,ventral hippocampus ,medial prefrontal cortex ,Cytology ,QH573-671 - Abstract
Metabotropic glutamate 5 receptors (mGlu5) are thought to play an important role in mediating emotional information processing. In particular, negative allosteric modulators (NAMs) of mGlu5 have received a lot of attention as potential novel treatments for several neuropsychiatric diseases, including anxiety-related disorders. The aim of this study was to assess the influence of pre- and post-training mGlu5 inactivation in cued fear conditioned mice on neuronal oscillatory activity during fear retrieval. For this study we used the recently developed mGlu5 NAM Alloswicth-1 administered systemically. Injection of Alloswicth-1 before, but not after, fear conditioning resulted in a significant decrease in freezing upon fear retrieval. Mice injected with Alloswicth-1 pre-training were also implanted with recording microelectrodes into both the medial prefrontal cortex (mPFC) and ventral hippocampus (vHPC). The recordings revealed a reduction in theta rhythmic activity (4–12 Hz) in both the mPFC and vHPC during fear retrieval. These results indicate that inhibition of mGlu5 signaling alters local oscillatory activity in principal components of the fear brain network underlying a reduced response to a predicted threat.
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- 2022
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34. Transiting exoplanets from the CoRoT space mission - XIX. CoRoT-23b: a dense hot Jupiter on an eccentric orbit
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Rouan, D., Parviainen, H., Moutou, C., Deleuil, M., Fridlund, M., Ofir, A., Havel, M., Aigrain, S., Alonso, R., Auvergne, M., Baglin, A., Barge, P., Bonomo, A., Bordé, P., Bouchy, F., Cabrera, J., Cavarroc, C., Csizmadia, Sz., Deeg, H., Diaz, R. F., Dvorak, R., Erikson, A., Ferraz-Mello, S., Gandolfi, D., Gillon, M., Guillot, T., Hatzes, A., Hébrard, G., Jorda, L., Léger, A., Llebaria, A., Lammer, H., Lovis, C., Mazeh, T., Ollivier, M., Pätzold, M., Queloz, D., Rauer, H., Samuel, B., Santerne, A., Schneider, J., Tingley, B., and Wuchterl, G.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We report the detection of CoRoT-23b, a hot Jupiter transiting in front of its host star with a period of 3.6314 \pm 0.0001 days. This planet was discovered thanks to photometric data secured with the CoRoT satellite, combined with spectroscopic radial velocity (RV) measurements. A photometric search for possible background eclipsing binaries conducted at CFHT and OGS concluded with a very low risk of false positives. The usual techniques of combining RV and transit data simultaneously were used to derive stellar and planetary parameters. The planet has a mass of Mp = 2.8 \pm 0.3 MJup, a radius of Rpl = 1.05 \pm 0.13 RJup, a density of \approx 3 g cm-3. RV data also clearly reveal a non zero eccentricity of e = 0.16 \pm 0.02. The planet orbits a mature G0 main sequence star of V =15.5 mag, with a mass M\star = 1.14 \pm 0.08 M\odot, a radius R\star = 1. 61 \pm 0.18 R\odot and quasi-solar abundances. The age of the system is evaluated to be 7 Gyr, not far from the transition to subgiant, in agreement with the rather large stellar radius. The two features of a significant eccentricity of the orbit and of a fairly high density are fairly uncommon for a hot Jupiter. The high density is, however, consistent with a model of contraction of a planet at this mass, given the age of the system. On the other hand, at such an age, circularization is expected to be completed. In fact, we show that for this planetary mass and orbital distance, any initial eccentricity should not totally vanish after 7 Gyr, as long as the tidal quality factor Qp is more than a few 105, a value that is the lower bound of the usually expected range. Even if Corot-23b features a density and an eccentricity that are atypical of a hot Jupiter, it is thus not an enigmatic object., Comment: Astronomy & Astrophysics in press
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- 2011
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35. Planetary transit candidates in the CoRoT LRa01 field
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Carone, L., Gandolfi, D., Cabrera, J., Hatzes, A. P., Deeg, H. J., Csizmadia, Sz., Paetzold, M., Weingrill, J., Aigrain, S., Alonso, R., Alapini, A., Almenara, J. -M., Auvergne, M., Baglin, A., Barge, P., Bonomo, A. S., Bordé, P., Bouchy, F., Bruntt, H., Carpano, S., Cochran, W. D., Deleuil, M., Díaz, R. F., Dreizler, S., Dvorak, R., Eisloeffel, J., Eigmueller, P., Endl, M., Erikson, A., Ferraz-Mello, S., Fridlund, M., Gazzano, J. -C., Gibson, N., Gillon, M., Gondoin, P., Grziwa, S., Guenther, E. W., Guillot, T., Hartmann, M., Havel, M., Hébrard, G., Jorda, L., Kabath, P., Léger, A., Llebaria, A., Lammer, H., Lovis, C., MacQueen, P. J., Mayor, M., Mazeh, T., Moutou, C., Nortmann, L., Ofir, A., Ollivier, M., Parviainen, H., Pepe, F., Pont, F., Queloz, D., Rabus, M., Rauer, H., Régulo, C., Renner, S., de la Reza, R., Rouan, D., Santerne, A., Samuel, B., Schneider, J., Shporer, A., Stecklum, B., Tal-Or, L., Tingley, B., Udry, S., and Wuchterl, G.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
Context: CoRoT is a pioneering space mission whose primary goals are stellar seismology and extrasolar planets search. Its surveys of large stellar fields generate numerous planetary candidates whose lightcurves have transit-like features. An extensive analytical and observational follow-up effort is undertaken to classify these candidates. Aims: The list of planetary transit candidates from the CoRoT LRa01 star field in the Monoceros constellation towards the Galactic anti-center is presented. The CoRoT observations of LRa01 lasted from 24 October 2007 to 3 March 2008. Methods: 7470 chromatic and 3938 monochromatic lightcurves were acquired and analysed. Instrumental noise and stellar variability were treated with several filtering tools by different teams from the CoRoT community. Different transit search algorithms were applied to the lightcurves. Results: Fifty-one stars were classified as planetary transit candidates in LRa01. Thirty-seven (i.e., 73 % of all candidates) are "good" planetary candidates based on photometric analysis only. Thirty-two (i.e., 87 % of the "good" candidates) have been followed-up. At the time of this writing twenty-two cases have been solved and five planets have been discovered: three transiting hot-Jupiters (CoRoT-5b, CoRoT-12b, and CoRoT-21b), the first terrestrial transiting planet (CoRoT-7b), and another planet in the same system (CoRoT-7c, detected by radial velocity survey only). Evidences of another non-transiting planet in the CoRoT-7 system, namely CoRoT-7d, have been recently found., Comment: 30 pages, 15 figures, accepted for publication in A&A, Section 14 "Catalogs and Data"
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- 2011
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36. CoRoT LRa02_E2_0121: Neptune-size planet candidate turns into a hierarchical triple system with a giant primary
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Tal-Or, L., Santerne, A., Mazeh, T., Bouchy, F., Moutou, C., Alonso, R., Gandolfi, D., Aigrain, S., Auvergne, M., Barge, P., Bonomo, A. S., Borde, P., Deeg, H., Ferraz-Mello, S., Deleuil, M., Dvorak, R., Erikson, A., Fridlund, M., Gillon, M., Guenther, E. W., Guillot, T., Hatzes, A., Jorda, L., Lammer, H., Leger, A., Llebaria, A., Ollivier, M., Patzold, M., Queloz, D., Rauer, H., Rouan, D., Tsodikovich, Y., and Wuchterl, G.
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
This paper presents the case of CoRoT LRa02_E2_0121, which was initially classified as a Neptune-size transiting-planet candidate on a relatively wide orbit of 36.3 days. Follow-up observations were performed with UVES, Sandiford, SOPHIE and HARPS. These observations revealed a faint companion in the spectra. To find the true nature of the system we derived the radial velocities of the faint companion using TODMOR - a two-dimensional correlation technique, applied to the SOPHIE spectra. Modeling the lightcurve with EBAS we discovered a secondary eclipse with a depth of ~0.07%, indicating a diluted eclipsing binary. Combined MCMC modeling of the lightcurve and the radial velocities suggested that CoRoT LRa02_E2_0121 is a hierarchical triple system with an evolved G-type primary and an A-type:F-type grazing eclipsing binary. Such triple systems are difficult to discover., Comment: 7 pages, 5 figures
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- 2011
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37. Transiting exoplanets from the CoRoT space mission. XVIII. CoRoT-18b: a massive hot jupiter on a prograde, nearly aligned orbit
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Hebrard, G., Evans, T. M., Alonso, R., Fridlund, M., Ofir, A., Aigrain, S., Guillot, T., Almenara, J. M., Auvergne, M., Baglin, A., Barge, P., Bonomo, A. S., Borde, P., Bouchy, F., Cabrera, J., Carone, L., Carpano, S., Cavarroc, C., Csizmadia, Sz., Deeg, H. J., Deleuil, M., Diaz, R. F., Dvorak, R., Erikson, A., Ferraz-Mello, S., Gandolfi, D., Gibson, N., Gillon, M., Guenther, E., Hatzes, A., Havel, M., Jorda, L., Lammer, H., Leger, A., Llebaria, A., Mazeh, T., Moutou, C., Ollivier, M., Parviainen, H., Patzold, M., Queloz, D., Rauer, H., Rouan, D., Santerne, A., Schneider, J., Tingley, B., and Wuchterl, G.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We report the detection of CoRoT-18b, a massive hot jupiter transiting in front of its host star with a period of 1.9000693 +/- 0.0000028 days. This planet was discovered thanks to photometric data secured with the CoRoT satellite combined with spectroscopic and photometric ground-based follow-up observations. The planet has a mass M_p = 3.47 +/- 0.38 M_Jup, a radius R_p = 1.31 +/- 0.18 R_Jup, and a density rho_p = 2.2 +/- 0.8 g/cm3. It orbits a G9V star with a mass M_* = 0.95 +/- 0.15 M_Sun, a radius R_* = 1.00 +/- 0.13 R_Sun, and a rotation period P_rot = 5.4 +/- 0.4 days. The age of the system remains uncertain, with stellar evolution models pointing either to a few tens Ma or several Ga, while gyrochronology and lithium abundance point towards ages of a few hundred Ma. This mismatch potentially points to a problem in our understanding of the evolution of young stars, with possibly significant implications for stellar physics and the interpretation of inferred sizes of exoplanets around young stars. We detected the Rossiter-McLaughlin anomaly in the CoRoT-18 system thanks to the spectroscopic observation of a transit. We measured the obliquity psi = 20 +/- 20 degrees (sky-projected value: lambda = -10 +/- 20 degrees), indicating that the planet orbits in the same way as the star is rotating and that this prograde orbit is nearly aligned with the stellar equator., Comment: 14 pages, 13 figures, 3 tables, A&A in press, final version
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- 2011
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38. Transiting exoplanets from the CoRoT space mission XVII. The hot Jupiter CoRoT-17b: a very old planet
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Csizmadia, Sz., Moutou, C., Deleuil, M., Cabrera, J., Fridlund, M., Gandolfi, D., Aigrain, S., Alonso, R., Almenara, J. M., Auvergne, M., Baglin, A., Barge, P., Bonomo, A. S., Borde, P., Bouchy, F., Bruntt, H., Carone, L., Carpano, S., Cavarroc, C., Cochran, W., Deeg, H. J., Diaz, R. F., Dvorak, R., Endl, M., Erikson, A., Ferraz-Mello, S., Fruth, Th., Gazzano, J. C., Gillon, M., Guenther, E. W., Guillot, T., Hatzes, A., Havel, M., Hebrard, G., Jehin, E., Jorda, L., Leger, A., Llebaria, A., Lammer, H., Lovis, C., MacQueen, P. J., Mazeh, T., Ollivier, M., Paetzold, M., Queloz, D., Rauer, H., Rouan, D., Santerne, A., Schneider, J., Tingley, B., Titz-Weider, R., and Wuchterl, G.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We report on the discovery of a hot Jupiter-type exoplanet, CoRoT-17b, detected by the CoRoT satellite. It has a mass of $2.43\pm0.30$\Mjup and a radius of $1.02\pm0.07$\Rjup, while its mean density is $2.82\pm0.38$ g/cm$^3$. CoRoT-17b is in a circular orbit with a period of $3.7681\pm0.0003$ days. The host star is an old ($10.7\pm1.0$ Gyr) main-sequence star, which makes it an intriguing object for planetary evolution studies. The planet's internal composition is not well constrained and can range from pure H/He to one that can contain $\sim$380 earth masses of heavier elements., Comment: Published (A&A 531, A41, 2011)
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- 2011
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39. Morphology, dynamics and plasma parameters of plumes and inter-plume regions in solar coronal holes
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Wilhelm, K., Abbo, L., Auchere, F., Barbey, N., Feng, L., Gabriel, A. H., Giordano, S., Imada, S., Llebaria, A., Matthaeus, W. H., Poletto, G., Raouafi, N. -E., Suess, S. T., Teriaca, L., and Wang, Y. -M.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
Coronal plumes, which extend from solar coronal holes (CH) into the high corona and - possibly - into the solar wind (SW), can now continuously be studied with modern telescopes and spectrometers on spacecraft, in addition to investigations from the ground, in particular, during total eclipses. Despite the large amount of data available on these prominent features and related phenomena, many questions remained unanswered as to their generation and relative contributions to the high-speed streams emanating from CHs. An understanding of the processes of plume formation and evolution requires a better knowledge of the physical conditions at the base of CHs, in plumes and in the surrounding inter-plume regions (IPR). More specifically, information is needed on the magnetic field configuration, the electron densities and temperatures, effective ion temperatures, non-thermal motions, plume cross-sections relative to the size of a CH, the plasma bulk speeds, as well as any plume signatures in the SW. In spring 2007, the authors proposed a study on "Structure and dynamics of coronal plumes and inter-plume regions in solar coronal holes" to the International Space Science Institute (ISSI) in Bern to clarify some of these aspects by considering relevant observations and the extensive literature. This review summarizes the results and conclusions of the study. Stereoscopic observations allowed us to include three-dimensional reconstructions of plumes. Multi-instrument investigations carried out during several campaigns led to progress in some areas, such as plasma densities, temperatures, plume structure and the relation to other solar phenomena, but not all questions could be answered concerning the details of plume generation process(es) and interaction with the SW., Comment: To appear on: The Astronomy and Astrophysics Review. 72 pages, 30 figures
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- 2011
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40. Transiting exoplanets from the CoRoT space mission: XIII. CoRoT-14b: an unusually dense very hot Jupiter
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Tingley, B., Endl, M., Gazzano, J. -C., Alonso, R., Mazeh, T., Jorda, L., Aigrain, S., Almenara, J. -M., Auvergne, M., Baglin, A., Barge, P., Bonomo, A. S., Bordé, P., Bouchy, F., Bruntt, H., Cabrera, J., Carpano, S., Carone, L., Cochran, W. D., Csizmadia, Sz., Deleuil, M., Deeg, H. J., Dvorak, R., Erikson, A., Ferraz-Mello, S., Fridlund, M., Gandolfi, D., Gillon, M., Guenther, E. W., Guillot, T., Hatzes, A., Hébrard, G., Léger, A., Llebaria, A., Lammer, H., Lovis, C., MacQueen, P. J., Moutou, C., Ollivier, M., Ofir, A., Pätzold, M., Pepe, F., Queloz, D., Rauer, H., Rouan, D., Samuel, B., Schneider, J., Shporer, A., and Wuchterl, G.
- Subjects
Astrophysics - Earth and Planetary Astrophysics - Abstract
In this paper, the CoRoT Exoplanet Science Team announces its 14th discovery. Herein, we discuss the observations and analyses that allowed us to derive the parameters of this system: a hot Jupiter with a mass of $7.6 \pm 0.6$ Jupiter masses orbiting a solar-type star (F9V) with a period of only 1.5 d, less than 5 stellar radii from its parent star. It is unusual for such a massive planet to have such a small orbit: only one other known exoplanet with a higher mass orbits with a shorter period., Comment: 7 pages, 10 figures, accepted to Astronomy and Astrophysics
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- 2011
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41. Transiting exoplanets from the CoRoT space mission XIV. CoRoT-11b: a transiting massive 'hot-Jupiter' in a prograde orbit around a rapidly rotating F-type star
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Gandolfi, D., Hébrard, G., Alonso, R., Deleuil, M., Guenther, E. W., Fridlund, M., Endl, M., Eigmüller, P., Csizmadia, Sz., Havel, M., Aigrain, S., Auvergne, M., Baglin, A., Barge, P., Bonomo, A. S., Bordé, P., Bouchy, F., Bruntt, H., Cabrera, J., Carpano, S., Carone, L., Cochran, W. D., Deeg, H. J., Dvorak, R., Eislöffel, J., Erikson, A., Ferraz-Mello, S., Gazzano, J. -C., Gibson, N. P., Gillon, M., Gondoin, P., Guillot, T., Hartmann, M., Hatzes, A., Jorda, L., Kabath, P., Léger, A., Llebaria, A., Lammer, H., MacQueen, P. J., Mayor, M., Mazeh, T., Moutou, C., Ollivier, M., Pätzold, M., Pepe, F., Queloz, D., Rauer, H., Rouan, D., Samuel, B., Schneider, J., Stecklum, B., Tingley, B., Udry, S., and Wuchterl, G.
- Subjects
Astrophysics - Earth and Planetary Astrophysics - Abstract
The CoRoT exoplanet science team announces the discovery of CoRoT-11b, a fairly massive hot-Jupiter transiting a V=12.9 mag F6 dwarf star (M*=1.27 +/- 0.05 Msun, R*=1.37 +/- 0.03 Rsun, Teff=6440 +/- 120 K), with an orbital period of P=2.994329 +/- 0.000011 days and semi-major axis a=0.0436 +/- 0.005 AU. The detection of part of the radial velocity anomaly caused by the Rossiter-McLaughlin effect shows that the transit-like events detected by CoRoT are caused by a planet-sized transiting object in a prograde orbit. The relatively high projected rotational velocity of the star (vsini=40+/-5 km/s) places CoRoT-11 among the most rapidly rotating planet host stars discovered so far. With a planetary mass of mp=2.33+/-0.34 Mjup and radius rp=1.43+/-0.03 Rjup, the resulting mean density of CoRoT-11b (rho=0.99+/-0.15 g/cm^3) can be explained with a model for an inflated hydrogen-planet with a solar composition and a high level of energy dissipation in its interior., Comment: 15 pages, 13 figures, accepted for publication in A&A
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- 2010
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42. Transiting exoplanets from the CoRoT space mission. XIII. CoRoT-13b: a dense hot Jupiter in transit around a star with solar metallicity and super-solar lithium content
- Author
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Cabrera, J., Bruntt, H., Ollivier, M., Diaz, R. F., Csizmadia, Sz., Aigrain, S., Alonso, R., Almenara, J. -M., Auvergne, M., Baglin, A., Barge, P., Bonomo, A. S., Borde, P., Bouchy, F., Carone, L., Carpano, S., Deleuil, M., Deeg, H. J., Dvorak, R., Erikson, A., Ferraz-Mello, S., Fridlund, M., Gandolfi, D., Gazzano, J. -C., Gillon, M., Guenther, E. W., Guillot, T., Hatzes, A., Havel, M., Hebrard, G., Jorda, L., Leger, A., Llebaria, A., Lammer, H., Lovis, C., Mazeh, T., Moutou, C., Ofir, A., von Paris, P., Patzold, M., Queloz, D., Rauer, H., Rouan, D., Santerne, A., Schneider, J., Tingley, B., Titz-Weider, R., and Wuchterl, G.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We announce the discovery of the transiting planet CoRoT-13b. Ground based follow-up in CFHT and IAC80 confirmed CoRoT's observations. The mass of the planet was measured with the HARPS spectrograph and the properties of the host star were obtained analyzing HIRES spectra from the Keck telescope. It is a hot Jupiter-like planet with an orbital period of 4.04 days, 1.3 Jupiter masses, 0.9 Jupiter radii, and a density of 2.34 g cm-3. It orbits a G0V star with Teff=5945K, M*=1.09 Msun, R*=1.01 Rsun, solar metallicity, a lithium content of +1.45 dex, and an estimated age between 0.12 and 3.15 Gyr. The lithium abundance of the star is consistent with its effective temperature, activity level, and age range derived from the stellar analysis. The density of the planet is extreme for its mass. It implies the existence of an amount of heavy elements with a mass between about 140 and 300 Mearth., Comment: 10 pages, 11 figures, accepted for publication in A&A
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- 2010
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43. Transiting exoplanets from the CoRoT space mission. XII. CoRoT-12b: a short-period low-density planet transiting a solar analog star
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Gillon, M., Hatzes, A., Csizmadia, Sz., Fridlund, M., Deleuil, M., Aigrain, S., Alonso, R., Auvergne, M., Baglin, A., Barge, P., Barnes, S. I., Bonomo, A. S., Bordé, P., Bouchy, F., Bruntt, H., Cabrera, J., Carone, L., Carpano, S., Cochran, W. D., Deeg, H. J., Dvorak, R., Endl, M., Erikson, A., Ferraz-Mello, S., Gandolfi, D., Gazzano, J. C., Guenther, E., Guillot, T., Havel, M., Hébrard, G., Jorda, L., Léger, A., Llebaria, A., Lammer, H., Lovis, C., Mayor, M., Mazeh, T., Montalbán, J., Moutou, C., Ofir, A., Ollivier, M., Pätzold, M., Pepe, F., Queloz, D., Rauer, H., Rouan, D., Samuel, B., Santerne, A., Schneider, J., Tingley, B., Udry, S., Weingrill, J., and Wuchterl, G.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We report the discovery by the CoRoT satellite of a new transiting giant planet in a 2.83 days orbit about a V=15.5 solar analog star (M_* = 1.08 +- 0.08 M_sun, R_* = 1.1 +- 0.1 R_sun, T_eff = 5675 +- 80 K). This new planet, CoRoT-12b, has a mass of 0.92 +- 0.07 M_Jup and a radius of 1.44 +- 0.13 R_Jup. Its low density can be explained by standard models for irradiated planets., Comment: 9 pages, 8 figures. Accepted for publication in Astronomy and Astrophysics
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- 2010
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44. CoRoT-10b: a giant planet in a 13.24 day eccentric orbit
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Bonomo, A. S., Santerne, A., Alonso, R., Gazzano, J. -C., Havel, M., Aigrain, S., Auvergne, M., Baglin, A., Barbieri, M., Barge, P., Benz, W., Bordé, P., Bouchy, F., Bruntt, H., Cabrera, J., Cameron, A. C., Carone, L., Carpano, S., Csizmadia, Sz., Deleuil, M., Deeg, H. J., Dvorak, R., Erikson, A., Ferraz-Mello, S., Fridlund, M., Gandolfi, D., Gillon, M., Guenther, E., Guillot, T., Hatzes, A., Hébrard, G., Jorda, L., Lammer, H., Lanza, A. F., Léger, A., Llebaria, A., Mayor, M., Mazeh, T., Moutou, C., Ollivier, M., Pätzold, M., Pepe, F., Queloz, D., Rauer, H., Rouan, D., Samuel, B., Schneider, J., Tingley, B., Udry, S., and Wuchterl, G.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
The space telescope CoRoT searches for transiting extrasolar planets by continuously monitoring the optical flux of thousands of stars in several fields of view. We report the discovery of CoRoT-10b, a giant planet on a highly eccentric orbit (e=0.53 +/- 0.04) revolving in 13.24 days around a faint (V=15.22) metal-rich K1V star. We use CoRoT photometry, radial velocity observations taken with the HARPS spectrograph, and UVES spectra of the parent star to derive the orbital, stellar and planetary parameters. We derive a radius of the planet of 0.97 +/- 0.07 R_Jup and a mass of 2.75 +/- 0.16 M_Jup. The bulk density, rho_pl=3.70 +/- 0.83 g/cm^3, is ~2.8 that of Jupiter. The core of CoRoT-10b could contain up to 240 M_Earth of heavy elements. Moving along its eccentric orbit, the planet experiences a 10.6-fold variation in insolation. Owing to the long circularisation time, tau_circ > 7 Gyr, a resonant perturber is not required to excite and maintain the high eccentricity of CoRoT-10b., Comment: 9 pages, 9 figures, accepted for publication by Astronomy and Astrophysics
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- 2010
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45. The SARS algorithm: detrending CoRoT light curves with Sysrem using simultaneous external parameters
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Ofir, Aviv, Alonso, Roi, Bonomo, Aldo Stefano, Carone, Ludmila, Carpano, Stefania, Samuel, Benjamin, Weingrill, Jorg, Aigrain, Suzanne, Auvergne, Michel, Baglin, Annie, Barge, Pierre, Borde, Pascal, Bouchy, Francois, Deeg, Hans J., Deleuil, Magali, Dvorak, Rudolf, Erikson, Anders, Mello, Sylvio Ferraz, Fridlund, Malcolm, Gillon, Michel, Guillot, Tristan, Hatzes, Artie, Jorda, Laurent, Lammer, Helmut, Leger, Alain, Llebaria, Antoine, Moutou, Claire, Ollivier, Marc, Paetzold, Martin, Queloz, Didier, Rauer, Heike, Rouan, Daniel, Schneider, Jean, and Wuchterl, Guenther
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Astrophysics - Earth and Planetary Astrophysics - Abstract
Surveys for exoplanetary transits are usually limited not by photon noise but rather by the amount of red noise in their data. In particular, although the CoRoT spacebased survey data are being carefully scrutinized, significant new sources of systematic noises are still being discovered. Recently, a magnitude-dependant systematic effect was discovered in the CoRoT data by Mazeh & Guterman et al. and a phenomenological correction was proposed. Here we tie the observed effect a particular type of effect, and in the process generalize the popular Sysrem algorithm to include external parameters in a simultaneous solution with the unknown effects. We show that a post-processing scheme based on this algorithm performs well and indeed allows for the detection of new transit-like signals that were not previously detected., Comment: MNRAS accepted. 5 pages, 3 figures
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- 2010
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46. Transiting exoplanets from the CoRoT space mission IX. CoRoT-6b: a transiting `hot Jupiter' planet in an 8.9d orbit around a low-metallicity star
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Fridlund, M., Hebrard, G., Alonso, R., Deleuil, M., Gandolfi, D., Gillon, M., Bruntt, H., Alapini, A., Csizmadia, Sz., Guillot, T., Lammer, H., Aigrain, S., Almenara, J. M., Auvergne, M., Baglin, A., Barge, P., Borde, P., Bouchy, F., Cabrera, J., Carone, L., Carpano, S., Deeg, H. J., De la Reza, R., Dvorak, R., Erikson, A., Ferraz-Mello, S., Guenther, E., Gondoin, P., Hartog, R. den, Hatzes, A., Jorda, L., Leger, A., Llebaria, A., Magain, P., Mazeh, T., Moutou, C., Ollivier, M., Patzold, M., Queloz, D., Rauer, H., Rouan, D., Samuel, B., Schneider, J., Shporer, A., Stecklum, B., Tingley, B., Weingrill, J., and Wuchterl, G.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
The CoRoT satellite exoplanetary team announces its sixth transiting planet in this paper. We describe and discuss the satellite observations as well as the complementary ground-based observations - photometric and spectroscopic - carried out to assess the planetary nature of the object and determine its specific physical parameters. The discovery reported here is a `hot Jupiter' planet in an 8.9d orbit, 18 stellar radii, or 0.08 AU, away from its primary star, which is a solar-type star (F9V) with an estimated age of 3.0 Gyr. The planet mass is close to 3 times that of Jupiter. The star has a metallicity of 0.2 dex lower than the Sun, and a relatively high $^7$Li abundance. While thelightcurveindicatesamuchhigherlevelof activity than, e.g., the Sun, there is no sign of activity spectroscopically in e.g., the [Ca ] H&K lines.
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- 2010
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47. Transit timing analysis of CoRoT-1b
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Csizmadia, Sz., Renner, S., Barge, P., Agol, E., Aigrain, S., Alonso, R., Almenara, J. M., Bonomo, A. S., Borde, P., Bouchy, F., Cabrera, J., Deeg, H. J., De la Reza, R., Deleuil, M., Dvorak, R., Erikson, A., Guenther, E. W., Fridlund, M., Gondoin, P., Guillot, T., Hatzes, A., Jorda, L., Lammer, H., Lázaro, C., Leger, A., Llebaria, A., Magain, P., Moutou, C., Ollivier, M., Paetzold, M., Queloz, D., Rauer, H., Rouan, D., Schneider, J., Wuchterl, G., and Gandolfi, D.
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
CoRoT, the pioneer space-based transit search, steadily provides thousands of high-precision light curves with continuous time sampling over periods of up to 5 months. The transits of a planet perturbed by an additional object are not strictly periodic. By studying the transit timing variations (TTVs), additional objects can be detected in the system. A transit timing analysis of CoRoT-1b is carried out to constrain the existence of additional planets in the system. We used data obtained by an improved version of the CoRoT data pipeline (version 2.0). Individual transits were fitted to determine the mid-transit times, and we analyzed the derived $O-C$ diagram. N-body integrations were used to place limits on secondary planets. No periodic timing variations with a period shorter than the observational window (55 days) are found. The presence of an Earth-mass Trojan is not likely. A planet of mass greater than $\sim 1$ Earth mass can be ruled out by the present data if the object is in a 2:1 (exterior) mean motion resonance with CoRoT-1b. Considering initially circular orbits: (i) super-Earths (less than 10 Earth-masses) are excluded for periods less than about 3.5 days, (ii) Saturn-like planets can be ruled out for periods less than about 5 days, (iii) Jupiter-like planets should have a minimum orbital period of about 6.5 days., Comment: 6 pages, accepted at A&A
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- 2009
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48. Transiting exoplanets from the CoRoT space mission: VII. The 'hot-Jupiter'-type planet CoRoT-5b
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Rauer, H., Queloz, D., Csizmadia, Sz., Deleuil, M., Alonso, R., Aigrain, S., Almenara, J. M., Auvergne, M., Baglin, A., Barge, P., Borde, P., Bouchy, F., Bruntt, H., Cabrera, J., Carone, L., Carpano, S., De la Reza, R., Deeg, H. J., Dvorak, R., Erikson, A., Fridlund, M., Gandolfi, D., Gillon, M., Guillot, T., Guenther, E., Hatzes, A., Hebrard, G., Kabath, P., Jorda, L., Lammer, H., Leger, A., Llebaria, A., Magain, P., Mazeh, T., Moutou, C., Ollivier, M., Paetzold, M., Pont, F., Rabus, M., Renner, S., Rouan, D., Shporer, A., Samuel, B., Schneider, J., Triaud, A. H. M. J., and Wuchterl, G.
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
Aims. The CoRoT space mission continues to photometrically monitor about 12 000 stars in its field-of-view for a series of target fields to search for transiting extrasolar planets ever since 2007. Deep transit signals can be detected quickly in the "alarm-mode" in parallel to the ongoing target field monitoring. CoRoT's first planets have been detected in this mode. Methods. The CoRoT raw lightcurves are filtered for orbital residuals, outliers, and low-frequency stellar signals. The phase folded lightcurve is used to fit the transit signal and derive the main planetary parameters. Radial velocity follow-up observations were initiated to secure the detection and to derive the planet mass. Results. We report the detection of CoRoT-5b, detected during observations of the LRa01 field, the first long-duration field in the galactic anticenter direction. CoRoT-5b is a "hot Jupiter-type" planet with a radius of 1.388(+0.046, -0.047) R_Jup, a mass of 0.467(+0.047, -0.024) M_Jup, and therefore, a mean density of 0.217(+0.031, -0.025) g cm-3. The planet orbits an F9V star of 14.0 mag in 4.0378962 +/- 0.0000019 days at an orbital distance of 0.04947(+0.00026, -0.00029) AU., Comment: 6 pages, 6 figures, 4 tables, accepted at A&A
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- 2009
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49. Transiting exoplanets from the CoRoT space mission VIII. CoRoT-7b: the first Super-Earth with measured radius
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Leger, A., Rouan, D., Schneider, J., Barge, P., Fridlund, M., Samuel, B., Ollivier, M., Guenther, E., Deleuil, M., Deeg, H. J., Auvergne, M., Alonso, R., Aigrain, S., Alapini, A., Almenara, J. M., Baglin, A., Barbieri, M., Bruntt, H., Borde, P., Bouchy, F., Cabrera, J., Catala, C., Carone, L., Carpano, S., Csizmadia, Sz., Dvorak, R., Erikson, A., Ferraz-Mello, S., Foing, B., Fressin, F., Gandolfi, D., Gillon, M., Gondoin, Ph., Grasset, O., Guillot, T., Hatzes, A., Hebrard, G., Jorda, L., Lammer, H., Llebaria, A., Loeillet, B., Mayor, M., Mazeh, T., Moutou, C., Paetzold, M., Pont, F., Queloz, D., Rauer, H, Renner, S., Samadi, R., Shporer, A., Sotin, Ch., Tingley, B., and Wuchterl, G.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
We report the discovery of very shallow (DF/F = 3.4 10-4), periodic dips in the light curve of an active V = 11.7 G9V star observed by the CoRoT satellite, which we interpret as due to the presence of a transiting companion. We describe the 3-colour CoRoT data and complementary ground-based observations that support the planetary nature of the companion. Methods. We use CoRoT color information, good angular resolution ground-based photometric observations in- and out- of transit, adaptive optics imaging, near-infrared spectroscopy and preliminary results from Radial Velocity measurements, to test the diluted eclipsing binary scenarios. The parameters of the host star are derived from optical spectra, which were then combined with the CoRoT light curve to derive parameters of the companion. We examine carefully all conceivable cases of false positives, and all tests performed support the planetary hypothesis. Blends with separation larger than 0.40 arcsec or triple systems are almost excluded with a 8 10-4 risk left. We conclude that, as far as we have been exhaustive, we have discovered a planetary companion, named CoRoT-7b, for which we derive a period of 0.853 59 +/- 3 10-5 day and a radius of Rp = 1.68 +/- 0.09 REarth. Analysis of preliminary radial velocity data yields an upper limit of 21 MEarth for the companion mass, supporting the finding. CoRoT-7b is very likely the first Super-Earth with a measured radius., Comment: Accepted in Astronomy and Astrophysics; typos and language corrections; version sent to the printer w few upgrades
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- 2009
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50. Planetary transit candidates in COROT-IRa01 field
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Carpano, S., Cabrera, J., Alonso, R., Barge, P., Aigrain, S., Almenara, J. -M., Bordé, P., Bouchy, F., Carone, L., Deeg, H. J., De la Reza, R., Deleuil, M., Dvorak, R., Erikson, A., Fressin, F., Fridlund, M., Gondoin, P., Guillot, T., Hatzes, A., Jorda, L., Lammer, H., Léger, A., Llebaria, A., Magain, P., Moutou, C., Ofir, A., Ollivier, M., Pacheco, E. J., Pátzold, M., Pont, F., Queloz, D., Rauer, H., Régulo, C., Renner, S., Rouan, D., Samuel, B., Schneider, J., and Wuchterl, G.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
Context: CoRoT is a pioneering space mission devoted to the analysis of stellar variability and the photometric detection of extrasolar planets. Aims: We present the list of planetary transit candidates detected in the first field observed by CoRoT, IRa01, the initial run toward the Galactic anticenter, which lasted for 60 days. Methods: We analysed 3898 sources in the coloured bands and 5974 in the monochromatic band. Instrumental noise and stellar variability were taken into account using detrending tools before applying various transit search algorithms. Results: Fifty sources were classified as planetary transit candidates and the most reliable 40 detections were declared targets for follow-up ground-based observations. Two of these targets have so far been confirmed as planets, COROT-1b and COROT-4b, for which a complete characterization and specific studies were performed., Comment: 11 pages, 8 figures
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- 2009
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