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1. MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer

Author

C. Kalogirou, J. Linxweiler, P. Schmucker, M. T. Snaebjornsson, W. Schmitz, S. Wach, M. Krebs, E. Hartmann, M. Puhr, A. Müller, M. Spahn, A. K. Seitz, T. Frank, H. Marouf, G. Büchel, M. Eckstein, H. Kübler, M. Eilers, M. Saar, K. Junker, F. Röhrig, B. Kneitz, M. T. Rosenfeldt, and A. Schulze

Subjects
Science
Abstract

Cholesterol metabolism is involved in the progression of aggressive prostate cancer (PCa). Here the authors show that miR-205 downregulation promotes cholesterol synthesis and androgen receptor signalling in PCa through enhancing the expression of the rate-limiting enzyme of cholesterol synthesis, squalene epoxidase.

Published
2021
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2. Navigating STEMification for Critical Geography Educators: Finding Leverage in Classroom and Institutional Pedagogies

Author

David K. Seitz, Daniel Cockayne, Ryan Z. Good, Kathryn L. Hannum, Adrianne C. Kroepsch, Mark Alan Rhodes II, Jack Swab, and Nancy Worth

Abstract

This paper grapples with the challenges posed to critical geography educators by STEMification, or the enshrinement of market-oriented forms of science and technology education as the normative ideal for education in general. In both reactionary and progressive contexts, STEMification decontextualizes scientific and technological activity and deepens existing hierarchies of knowledge based on quantification, perceived scientific rigour, commercialisation, and employability. Critical geographical knowledges often incur misrecognition, dismissal, and in some cases, outright prohibition under such conditions. Offering strategies for navigating and contesting STEMification, this paper draws on collective auto-methods, analysing narrative vignettes from our pedagogical practices as critical geography educators. We offer the notion of seeking leverage in the face of STEMification: protecting ourselves and seeking traction within our institutions by translating our goals into familiar or sanctioned forms, while using those forms to alternative ends. To that end, we highlight seven pedagogical strategies: (1) meeting students where they are, (2) using applied examples, (3) grappling with the limits of problem-based learning, (4) disalienating students from assessment, (5) integrating critique with alternatives, (6) anticipating both resistance to and desire for critical content from students and colleagues, and (7) recognising the limits of institutional environments.

Published
2024
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3. Playing with 'Star Trek' in the Critical Geography Classroom: STEM Education and Otherwise Possibilities

Author

David K. Seitz

Abstract

This paper reflects on the classroom use of the "Star Trek" American science fiction television franchise to teach critical and emotional geographies to undergraduates specializing in science, technology, education, and mathematics (STEM). Both science fiction and STEM education are ambivalent and contradictory scenes of social reproduction, extending a promise of social transformation, but often maintaining complicity in heteropatriarchy, racial capitalism, and empire. Enlivening students to what Ashon T. Crawley calls the "otherwise possibilities" immanent to both science fiction and STEM education is necessarily difficult emotional work. Reflecting on teacher shame and anxiety and student resistance to course material, I turn to psychoanalysis, particularly the work of Donald W. Winnicott, to argue that "Star Trek" offers a richly contradictory "transitional object" for students to play with otherwise possibilities.

Published
2023
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5. Molecular, Viral and Clinical Features of Alcohol- and Non-Alcohol-Induced Liver Injury

Author

Manuela G. Neuman, Helmut K. Seitz, Rolf Teschke, Stephen Malnick, Kamisha L. Johnson-Davis, Lawrence B. Cohen, Anit German, Nicolas Hohmann, Bernhardo Moreira, George Moussa, and Mihai Opris

Subjects
alcoholic liver disease, apoptosis, cellular toxicity, cytokines, cytochrome P450, inflammation, Biology (General), QH301-705.5
Abstract

Hepatic cells are sensitive to internal and external signals. Ethanol is one of the oldest and most widely used drugs in the world. The focus on the mechanistic engine of the alcohol-induced injury has been in the liver, which is responsible for the pathways of alcohol metabolism. Ethanol undergoes a phase I type of reaction, mainly catalyzed by the cytoplasmic enzyme, alcohol dehydrogenase (ADH), and by the microsomal ethanol-oxidizing system (MEOS). Reactive oxygen species (ROS) generated by cytochrome (CYP) 2E1 activity and MEOS contribute to ethanol-induced toxicity. We aimed to: (1) Describe the cellular, pathophysiological and clinical effects of alcohol misuse on the liver; (2) Select the biomarkers and analytical methods utilized by the clinical laboratory to assess alcohol exposure; (3) Provide therapeutic ideas to prevent/reduce alcohol-induced liver injury; (4) Provide up-to-date knowledge regarding the Corona virus and its affect on the liver; (5) Link rare diseases with alcohol consumption. The current review contributes to risk identification of patients with alcoholic, as well as non-alcoholic, liver disease and metabolic syndrome. Additional prevalence of ethnic, genetic, and viral vulnerabilities are presented.

Published
2022
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6. Pathogenesis of Alcoholic Fatty Liver a Narrative Review

Author

Helmut K. Seitz, Bernardo Moreira, and Manuela G. Neuman

Subjects
alcoholic fatty liver, adenosine monophosphate activated kinase, sterol regulatory element binding protein 1c, peroxisome proliferator activated receptor α, oxidative stress, cytochrome P450 2E1, Science
Abstract

Alcohol effect hepatic lipid metabolism through various mechanisms, leading synergistically to an accumulation of fatty acids (FA) and triglycerides. Obesity, as well as dietary fat (saturated fatty acids (FA) versus poly-unsaturated fatty acids (PUFA)) may modulate the hepatic fat. Alcohol inhibits adenosine monophosphate activated kinase (AMPK). AMPK activates peroxisome proliferator activated receptor a (PPARα) and leads to a decreased activation of sterol regulatory element binding protein 1c (SRABP1c). The inhibition of AMPK, and thus of PPARα, results in an inhibition of FA oxidation. This ß-oxidation is further reduced due to mitochondrial damage induced through cytochrome P4502E1 (CYP2E1)-driven oxidative stress. Furthermore, the synthesis of FAs is stimulated through an activation of SHREP1. In addition, alcohol consumption leads to a reduced production of adiponectin in adipocytes due to oxidative stress and to an increased mobilization of FAs from adipose tissue and from the gut as chylomicrons. On the other side, the secretion of FAs via very-low-density lipoproteins (VLDL) from the liver is inhibited by alcohol. Alcohol also affects signal pathways such as early growth response 1 (Egr-1) associated with the expression of tumour necrosis factor α (TNF α), and the mammalian target of rapamycin (mTOR) a key regulator of autophagy. Both have influence the pathogenesis of alcoholic fatty liver. Alcohol-induced gut dysbiosis contributes to the severity of ALD by increasing the metabolism of ethanol in the gut and promoting intestinal dysfunction. Moreover, pathogen-associated molecular patterns (PAMPS) via specific Toll-like receptor (TLR) bacterial overgrowth leads to the translocation of bacteria. Endotoxins and toxic ethanol metabolites enter the enterohepatic circulation, reaching the liver and inducing the activation of the nuclear factor kappa-B (NFκB) pathway. Pro-inflammatory cytokines released in the process contribute to inflammation and fibrosis. In addition, cellular apoptosis is inhibited in favour of necrosis.

Published
2023
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10. Index

Author

David K. Seitz

Published
2017

13. Notes

Author

David K. Seitz

Published
2017

18. Cover

Author

David K. Seitz

Published
2017

21. A wizard of disquietude in our midst: Melanie Klein and the critical geographies of manic reparation

Author

David K Seitz

Subjects
Geography, Planning and Development, Environmental Science (miscellaneous)
Abstract

This article invites critical geographers to reconsider the conceptual offerings of Austrian-British object-relations psychoanalyst Melanie Klein (1882–1960), whose metapsychology has had a significant but largely unacknowledged contemporary influence on the field via theorists like Eve Kosofsky Sedgwick and Lauren Berlant. Excavating the Kleinian genealogies of Sedgwick’s concept of “reparative reading” and Berlant’s notion of “cruel optimism,” I argue that geographers engaged with these ideas would benefit from a more sustained consideration of Klein’s influence on them. I then point to the potential utility for critical geographers of just one of many Kleinian concepts that has largely remained off the map of recent debates: ”manic reparation,” sometimes referred to as mock reparation or manic denial, which defends against the anxiety of wanting to repair a damaged object of attachment. Sketching possibilities for how this concept could productively illuminate concerns near and dear to critical geographers—such as the political ecologies of climate change, critiques of neoliberal multiculturalisms, debates over urban development, and abolition geographies—I argue that Klein’s idiosyncratic, though at times problematic and counterintuitive, body of work offers critical geographers an insightful, expansive, and underutilized conceptual vocabulary for examining the affective dimensions of a wide range of political formations.

Published
2023
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22. Virus variant–specific clinical performance of SARS coronavirus two rapid antigen tests in point-of-care use, from November 2020 to January 2022

Author

Isabell Wagenhäuser, Kerstin Knies, Daniela Hofmann, Vera Rauschenberger, Michael Eisenmann, Julia Reusch, Alexander Gabel, Sven Flemming, Oliver Andres, Nils Petri, Max S. Topp, Michael Papsdorf, Miriam McDonogh, Raoul Verma-Führing, Agmal Scherzad, Daniel Zeller, Hartmut Böhm, Anja Gesierich, Anna K. Seitz, Michael Kiderlen, Micha Gawlik, Regina Taurines, Thomas Wurmb, Ralf-Ingo Ernestus, Johannes Forster, Dirk Weismann, Benedikt Weißbrich, Lars Dölken, Johannes Liese, Lars Kaderali, Oliver Kurzai, Ulrich Vogel, and Manuel Krone

Subjects
Microbiology (medical), Infectious Diseases, General Medicine
Abstract

Antigen rapid diagnostic tests (RDTs) for SARS coronavirus 2 (SARS-CoV-2) are quick, widely available, and inexpensive. Consequently, RDTs have been established as an alternative and additional diagnostic strategy to quantitative reverse transcription polymerase chain reaction (RT-qPCR). However, reliable clinical and large-scale performance data specific to a SARS-CoV-2 virus variant of concern (VOC) are limited, especially for the Omicron VOC. The aim of this study was to compare RDT performance among different VOCs.This single-centre prospective performance assessment compared RDTs from three manufacturers (NADAL, Panbio, MEDsan) with RT-qPCR including deduced standardized viral load from oropharyngeal swabs for detection of SARS-CoV-2 in a clinical point-of-care setting from November 2020 to January 2022.Among 35 479 RDT/RT-qPCR tandems taken from 26 940 individuals, 164 of the 426 SARS-CoV-2 positive samples tested true positive with an RDT corresponding to an RDT sensitivity of 38.50% (95% CI, 34.00-43.20%), with an overall specificity of 99.67% (95% CI, 99.60-99.72%). RDT sensitivity depended on viral load, with decreasing sensitivity accompanied by descending viral load. VOC-dependent sensitivity assessment showed a sensitivity of 42.86% (95% CI, 32.82-53.52%) for the wild-type SARS-CoV-2, 43.42% (95% CI, 32.86-54.61%) for the Alpha VOC, 37.67% (95% CI, 30.22-45.75%) for the Delta VOC, and 33.67% (95% CI, 25.09-43.49%) for the Omicron VOC. Sensitivity in samples with high viral loads of ≥10RDT sensitivity for detection of the Omicron VOC is reduced in individuals infected with a high viral load, which curtails the effectiveness of RDTs. This aspect furthert: limits the use of RDTs, although RDTs are still an irreplaceable diagnostic tool for rapid, economic point-of-care and extensive SARS-CoV-2 screening.

Published
2023
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23. Encountering Berlant part one: Concepts otherwise

Author

Ben Anderson, Stuart Aitken, Jana Bacevic, Felicity Callard, Kwang Dae (Mitsy) Chung, Kathryn S. Coleman, Robert F. Hayden, Sarah Healy, Rita L. Irwin, Thomas Jellis, Joe Jukes, Salman Khan, Steve Marotta, David K. Seitz, Kim Snepvangers, Adam Staples, Chloe Turner, Justin Tse, Marthy Watson, and Eleanor Wilkinson

Subjects
Geography, Planning and Development, Uncategorized, Earth-Surface Processes
Abstract

In Part 1 of ‘Encountering Berlant’, we encounter the promise and provocation of Lauren Berlant's work. In 1000-word contributions, geographers and others stay with what Berlant's thought offers contemporary human geography. They amplify an encounter with their work, demonstrating how a concept, idea, or style disrupts something, opens up a new possibility, or simply invites thinking otherwise. The encounters range across the incredible body of work Berlant left us with, from the ‘national sentimentality’ trilogy through to recent work on negativity. Varying in form and tone, the encounters exemplify and enact the inexhaustible plenitude of Berlant's thought: fantasy, the case, love, impasse, feel tanks, slow death, ellipses, gesture, attrition, intimate public, ambivalence, style. Part 2 of ‘Encountering Berlant’ focuses on Berlant's most influential concept: ‘cruel optimism’. Across these heterogeneous encounters, Berlant's enduring concern with the tensions and possibilities of relationality and how to enact better forms of common life shine through. These enduring concerns and Berlant's commitment to the incoherence and overdetermination of phenomena are summarised in the Introduction, which also explores how Berlant's work has been engaged with in geography. The result is a repository of what an encounter with Berlant's thought makes possible.

Published
2022
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29. 'Migration Is Not a Crime': Migrant Justice and the Creative Uses of Paddington Bear

Author

David K. Seitz

Subjects
Character (mathematics), Aesthetics, Bond, Geography, Planning and Development, Product (category theory), Sociology, Economic Justice, Earth-Surface Processes
Abstract

Created in 1957, the well-known English children’s book character Paddington Bear is the product of a dizzying number of displacements. Author Michael Bond (1926–2017) was inspired to make Paddingt...

Published
2021
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31. Eve Kosofsky Sedgwick and the difference geography makes

Author

David K. Seitz

Subjects
Politics, Psychoanalysis, 0602 languages and literature, 05 social sciences, Geography, Planning and Development, 0507 social and economic geography, Queer, Queer theory, 06 humanities and the arts, Affect (linguistics), 060202 literary studies, 050703 geography
Abstract

Ruez and Cockayne point out that queer theorist Eve Sedgwick’s reflections on paranoid and reparative readings accompanying one another came directly out of her queer political as well as textual practice in the U.S. Wrongly dismissed as mundane, this crucial contextualizing work is something geographers do especially well. Indeed, understanding the context for Sedgwick’s theories of paranoid and reparative reading is vital as we reflect on how her concepts travel across time and space.

Published
2021
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32. Effect of Clomethiazole Vs. Clorazepate on Hepatic Fat and Serum Transaminase Activities in Alcohol-Associated Liver Disease: Results from a Randomized, Controlled Phase II Clinical Trial

Author

Nicolas Hohmann, Fabian Schröder, Bernardo Moreira, Haidong Teng, Jürgen Burhenne, Thomas Bruckner, Sebastian Mueller, Walter E Haefeli, and Helmut K Seitz

Subjects
General Medicine
Abstract

AimsAlcohol-associated liver disease (ALD) is a global health problem caused, among other factors, by oxidative stress from the formation of reactive oxygen species (ROS). One important source of ROS is microsomal ethanol metabolism catalyzed by cytochrome P450 2E1 (CYP2E1), which is induced by chronic ethanol consumption. Inhibition of CYP2E1 by clomethiazole (CMZ) decreases oxidative stress in cell cultures and improves ALD in animal studies. Our study aimed to assess the benefits of a CYP2E1 inhibitor (clomethiazole) in detoxification of patients with ALD.MethodsOpen label, randomized controlled clinical trial to study whether CYP2E1 inhibition improves ALD in the patients with alcohol use disorders admitted for alcohol detoxification therapy (ADT). Patients had to have a serum aspartate aminotransferase (AST) activity exceeding twice the upper normal limit at time of admission and be non-cirrhotic defined by fibroscan value ResultsADT improved hepatic steatosis (controlled attenuation parameter) in both groups significantly. A trend towards a greater improvement in hepatic fat content during ADT (−21.5%) was observed in the CMZ group (252 ± 48 dB/m vs. 321 ± 38 dB/m; P ConclusionThis study demonstrates that CMZ improves clinical biomarkers for ALD in humans most likely due to its inhibitory effect on CYP2E1. Because of its addictive potential, CMZ can only be given for a short period of time and therefore other CYP2E1 inhibitors to treat ALD are needed.

Published
2022

33. The psychic life of gentrification: mapping desire and resentment in the gentrifying city

Author

Jesse Proudfoot and David K. Seitz

Subjects
Cultural Studies, Psychoanalysis, Resentment, media_common.quotation_subject, Geography, Planning and Development, Environmental Science (miscellaneous), Gentrification, Psychic, Queer, Sociology, Affect (linguistics), Psychoanalytic theory, Everyday life, media_common
Abstract

Following the lead of artists and scholars in Black, feminist, psychoanalytic, and queer studies and geographies, this special issue and editorial call for greater scholarly attention to the conscious and unconscious emotional, psychic, and affective dimensions of urban gentrification. While geographical scholarship frequently gestures to gentrification as an affective scene, these connections are generally suggested rather than developed. We argue that psychoanalytic and affect theories have richly developed conceptual and explanatory paradigms that can help scholars make sense of the sometimes granular, mundane ways gentrification is both facilitated and contested. Our aim here is not to displace Marxist political economies of gentrification that support a right to the city, a body of work with political stakes that we also claim. Rather, our goal is to supplement political economy’s rather focused inquiry into gentrification’s ‘proper’ political-economic dimensions, in the hopes of offering further insight into gentrification’s libidinal economies, which are conditioned by racial capitalist social relations but also exceed them.

Published
2021
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35. 'Missing' Racialized Violence, Disturbing Continuities: Countertopographies of Violence in the Bruce McArthur Murders

Author

David K. Seitz

Subjects
Cultural Studies, History, White (horse), Aggression, 05 social sciences, 0507 social and economic geography, Media coverage, Criminology, 050701 cultural studies, 050903 gender studies, medicine, 0509 other social sciences, medicine.symptom
Abstract

This article argues that media coverage of the 2010–17 Toronto gay village homicides avoids one of the central patterns in the case: the murderous aggression of a white gay man, Bruce McArthur, against racialized men, most of them from the Middle East or South Asia. It argues that even coverage that is sensitive to intersectionality tends to treat race, class, and immigration status as secondary to sexual orientation, making racialized queer migrants a “sub-group” of a normatively white lesbian, gay, bisexual, trans, and queer community. The article calls for sustained engagement with the specific, racialized character of much of the violence in the McArthur case. With inspiration from queer diasporic, transnational feminist, and feminist geographical methods, it points to continuities between McArthur’s racialized violence and the effects of Canadian white supremacy, imperialism, and capitalist inequality on Afghan and Sri Lankan refugees across diasporas. These effects notably include Canada’s 2002–14 role in the occupation of Afghanistan and the 2010 detainment of Sri Lankan Tamil passengers on the MV Sun Sea. The article concludes that critical reckoning with racialized violence as racialized violence is crucial to any hope of reparation in the wake of the McArthur case.

Published
2020
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36. Obesity, Diabetes, Coffee, Tea, and Cannabis Use Alter Risk for Alcohol-Related Cirrhosis in 2 Large Cohorts of High-Risk Drinkers

Author

Florian Eyer, Suthat Liangpunsakul, Pascal Perney, Dermot Gleeson, John Whitfield, Timothy R. Morgan, Guruprasad P. Aithal, Pierre Nahon, Devanshi Seth, Felix Stickel, Steven Masson, Sylvie Naveau, Romain Moirand, Helmut K. Seitz, Lawrence Lumeng, Michael Soyka, Beat Muellhaupt, Philippe Mathurin, Paul S. Haber, Heather J. Cordell, Sebastian Mueller, Andrew Thompson, Bertrand Nalpas, Tatiana Foroud, Christopher P. Day, Munir Pirmohamed, Ann K. Daly, Jean-Marc Jacquet, QIMR Berghofer Medical Research Institute, Newcastle University [Newcastle], Indiana University System, Heidelberg University, University of Nottingham, UK (UON), Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Royal Hallamshire Hospital, University of Liverpool, University hospital of Zurich [Zurich], University-Hospital Munich-Großhadern [München], Indiana University School of Medicine, Hôpital Universitaire Carémeau [Nîmes] (CHU Nîmes), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Nutrition, Métabolismes et Cancer (NuMeCan), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Pontchaillou [Rennes], Génomique Fonctionnelle des Tumeurs Solides (U1162), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Jean Verdier [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), AP-HP - Hôpital Antoine Béclère [Clamart], The University of Sydney, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), California State University [Long Beach] (CSULB ), University of California (UC), Jonchère, Laurent, Technical University of Munich (TUM), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of California, Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)

Subjects
Male, medicine.medical_specialty, Cirrhosis, Alcohol Drinking, [SDV]Life Sciences [q-bio], Wine, Coffee, 03 medical and health sciences, Liver disease, 0302 clinical medicine, Liver Cirrhosis, Alcoholic, Risk Factors, Weight loss, Germany, Diabetes mellitus, Internal medicine, Diabetes Mellitus, medicine, Humans, Obesity, Medical History Taking, 2. Zero hunger, Tea, Hepatology, business.industry, Alcoholic Beverages, Smoking, Australia, Gastroenterology, Case-control study, Odds ratio, Middle Aged, medicine.disease, United Kingdom, United States, 3. Good health, [SDV] Life Sciences [q-bio], Logistic Models, Case-Control Studies, 030220 oncology & carcinogenesis, Female, Marijuana Use, 030211 gastroenterology & hepatology, France, medicine.symptom, business, Body mass index, Switzerland
Abstract

International audience; Introduction - Sustained high alcohol intake is necessary but not sufficient to produce alcohol-related cirrhosis. Identification of risk factors, apart from lifetime alcohol exposure, would assist in discovery of mechanisms and prediction of risk. Methods - We conducted a multicenter case-control study (GenomALC) comparing 1,293 cases (with alcohol-related cirrhosis, 75.6% male) and 754 controls (with equivalent alcohol exposure but no evidence of liver disease, 73.6% male). Information confirming or excluding cirrhosis, and on alcohol intake and other potential risk factors, was obtained from clinical records and by interview. Case-control differences in risk factors discovered in the GenomALC participants were validated using similar data from 407 cases and 6,573 controls from UK Biobank. Results - The GenomALC case and control groups reported similar lifetime alcohol intake (1,374 vs 1,412 kg). Cases had a higher prevalence of diabetes (20.5% (262/1,288) vs 6.5% (48/734), P = 2.27 × 10) and higher premorbid body mass index (26.37 ± 0.16 kg/m) than controls (24.44 ± 0.18 kg/m, P = 5.77 × 10). Controls were significantly more likely to have been wine drinkers, coffee drinkers, smokers, and cannabis users than cases. Cases reported a higher proportion of parents who died of liver disease than controls (odds ratio 2.25 95% confidence interval 1.55-3.26). Data from UK Biobank confirmed these findings for diabetes, body mass index, proportion of alcohol as wine, and coffee consumption. Discussion - If these relationships are causal, measures such as weight loss, intensive treatment of diabetes or prediabetic states, and coffee consumption should reduce the risk of alcohol-related cirrhosis.

Published
2020
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37. Immunonkologische Ansätze in der perioperativen Therapie des muskelinvasiven Urothelkarzinoms

Author

Sebastian Schmid, F Beckert, F J Koll, and A K Seitz

Subjects
Gynecology, medicine.medical_specialty, Bladder cancer, business.industry, Urology, Muscle invasive, Perioperative, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, medicine, 030212 general & internal medicine, business
Abstract

Die perioperative Chemotherapie ist zu einem Standardverfahren in der Behandlung des muskelinvasiven Urothelkarzinoms geworden und wird von den nationalen und internationalen Leitlinien empfohlen. In den letzten Jahren verbesserte sich die Behandlung des metastasierten Urothelkarzinoms durch den Einsatz der immunmodulierenden Therapie in Form der Checkpoint-Inhibitoren. Um die Rolle der Immuntherapie in der Neoadjuvanz und Adjuvanz zu klaren, wurde eine Reihe von klinischen Studien initiiert. Dabei wird nicht nur die Monotherapie untersucht, sondern auch die Kombination mit Chemotherapie, ebenso wie die Kombination mit einer neoadjuvanten Strahlentherapie (Radioimmuntherapie). Bei der neoadjuvanten Radioimmuntherapie soll die Bestrahlung als „Sensitizer“ fur die Immuntherapie wirken und so zusatzlich zum lokalen Effekt die systemische Wirksamkeit der immunmodulierenden Therapie unterstutzen. In diesem Beitrag soll die Studiensituation und bereits vorhandene Daten zu immunonkologischen Ansatzen in der perioperativen Systemtherapie vorgestellt und diskutiert werden.

Published
2020
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39. In situ measurements of molecular iodine in the marine boundary layer: the link to macroalgae and the implications for O3, IO, OIO and NOx

Author

U. Platt, L. J. Carpenter, K. E. Hornsby, D. Pöhler, J. Buxmann, K. Seitz, R.-J. Huang, and T. Hoffmann

Subjects
Physics, QC1-999, Chemistry, QD1-999
Abstract

Discrete in situ atmospheric measurements of molecular iodine (I2) were carried out at Mace Head and Mweenish Bay on the west coast of Ireland using diffusion denuders in combination with a gas chromatography-mass spectrometry (GC-MS) method. I2, IO and OIO were also measured by long-path differential optical absorption spectroscopy (LP-DOAS). The simultaneous denuder and LP-DOAS I2 measurements were well correlated (R2=0.80) but the denuder method recorded much higher concentrations. This can be attributed to the fact that the in situ measurements were made near to macroalgal sources of I2 in the intertidal zone, whereas the LP-DOAS technique provides distance-averaged mixing ratios of an inhomogeneous distribution along the light-path. The observed mixing ratios of I2 at Mweenish Bay were significantly higher than that at Mace Head, which is consistent with differences in local algal biomass density and algal species composition. Above algal beds, levels of I2 were found to correlate inversely with tidal height and positively with the concentrations of O3 in the surrounding air, indicating a role for O3 in the production of I2 from macroalgae, as has been previously suggested from laboratory studies. However, measurements made ~150 m away from the algal beds showed a negative correlation between O3 and I2 during both day and night. We interpret these results to indicate that the released I2 can also lead to O3 destruction via the reaction of O3 with I atoms that are formed by the photolysis of I2 during the day and via the reaction of I2 with NO3 radicals at night. The results show that the concentrations of daytime IO are correlated with the mixing ratios of I2, and suggest that the local algae sources dominate the inorganic iodine chemistry at Mace Head and Mweenish Bay.

Published
2010
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40. Erratum to: Measurement of exclusive Υ photoproduction from protons in pPb collisions at s NN = 5.02 TeV (The European Physical Journal C, (2019), 79, 3, (277), 10.1140/epjc/s10052-019-6774-8)

Author

Sirunyan, A.M. Tumasyan, A. Adam, W. Ambrogi, F. Asilar, E. Bergauer, T. Brandstetter, J. Brondolin, E. Dragicevic, M. Erö, J. Valle, A.E.D. Flechl, M. Friedl, M. Frühwirth, R. Ghete, V.M. Grossmann, J. Hrubec, J. Jeitler, M. König, A. Krammer, N. Krätschmer, I. Liko, D. Madlener, T. Mikulec, I. Pree, E. Rad, N. Rohringer, H. Schieck, J. Schöfbeck, R. Spanring, M. Spitzbart, D. Taurok, A. Waltenberger, W. Wittmann, J. Wulz, C.-E. Zarucki, M. Chekhovsky, V. Mossolov, V. Gonzalez, J.S. De Wolf, E.A. Croce, D.D. Janssen, X. Lauwers, J. Pieters, M. De Klundert, M.V. Haevermaet, H.V. Mechelen, P.V. Remortel, N.V. Zeid, S.A. Blekman, F. D’Hondt, J. De Bruyn, I. De Clercq, J. Deroover, K. Flouris, G. Lontkovskyi, D. Lowette, S. Marchesini, I. Moortgat, S. Moreels, L. Python, Q. Skovpen, K. Tavernier, S. Doninck, W.V. Mulders, P.V. Parijs, I.V. Beghin, D. Bilin, B. Brun, H. Clerbaux, B. De Lentdecker, G. Delannoy, H. Dorney, B. Fasanella, G. Favart, L. Goldouzian, R. Grebenyuk, A. Kalsi, A.K. Lenzi, T. Luetic, J. Seva, T. Starling, E. Velde, C.V. Vanlaer, P. Vannerom, D. Yonamine, R. Cornelis, T. Dobur, D. Fagot, A. Gul, M. Khvastunov, I. Poyraz, D. Roskas, C. Trocino, D. Tytgat, M. Verbeke, W. Vermassen, B. Vit, M. Zaganidis, N. Bakhshiansohi, H. Bondu, O. Brochet, S. Bruno, G. Caputo, C. Caudron, A. David, P. De Visscher, S. Delaere, C. Delcourt, M. Francois, B. Giammanco, A. Krintiras, G. Lemaitre, V. Magitteri, A. Mertens, A. Musich, M. Piotrzkowski, K. Quertenmont, L. Saggio, A. Marono, M.V. Wertz, S. Zobec, J. Júnior, W.L.A. Alves, F.L. Alves, G.A. Brito, L. Silva, G.C. Hensel, C. Moraes, A. Pol, M.E. Teles, P.R. Chagas, E.B.B.D. Carvalho, W. Chinellato, J. Coelho, E. Da Costa, E.M. Da Silveira, G.G. De Jesus Damiao, D. De Souza, S.F. Malbouisson, H. Jaime, M.M. De Almeida, M.M. Herrera, C.M. Mundim, L. Nogima, H. Rosas, L.J.S. Santoro, A. Sznajder, A. Thiel, M. Manganote, E.J.T. Da Silva De Araujo, F.T. Pereira, A.V. Ahuja, S. Bernardes, C.A. Calligaris, L. Tomei, T.R.F.P. Gregores, E.M. Mercadante, P.G. Novaes, S.F. Padula, S.S. Abad, D.R. Vargas, J.C.R. Aleksandrov, A. Hadjiiska, R. Iaydjiev, P. Marinov, A. Misheva, M. Rodozov, M. Shopova, M. Sultanov, G. Dimitrov, A. Litov, L. Pavlov, B. Petkov, P. Fang, W. Gao, X. Yuan, L. Ahmad, M. Bian, J.G. Chen, G.M. Chen, H.S. Chen, M. Chen, Y. Jiang, C.H. Leggat, D. Liao, H. Liu, Z. Romeo, F. Shaheen, S.M. Spiezia, A. Tao, J. Wang, C. Wang, Z. Yazgan, E. Zhang, H. Zhao, J. Ban, Y. Chen, G. Li, J. Li, Q. Liu, S. Mao, Y. Qian, S.J. Wang, D. Xu, Z. Wang, Y. Avila, C. Cabrera, A. Montoya, C.A.C. Sierra, L.F.C. Florez, C. Hernández, C.F.G. Delgado, M.A.S. Courbon, B. Godinovic, N. Lelas, D. Puljak, I. Cipriano, P.M.R. Sculac, T. Antunovic, Z. Kovac, M. Brigljevic, V. Ferencek, D. Kadija, K. Mesic, B. Starodumov, A. Susa, T. Ather, M.W. Attikis, A. Mavromanolakis, G. Mousa, J. Nicolaou, C. Ptochos, F. Razis, P.A. Rykaczewski, H. Finger, M. Finger, M., Jr. Jarrin, E.C. Khalil, S. Mahmoud, M.A. Mohammed, Y. Bhowmik, S. Dewanjee, R.K. Kadastik, M. Perrini, L. Raidal, M. Veelken, C. Eerola, P. Kirschenmann, H. Pekkanen, J. Voutilainen, M. Havukainen, J. Heikkilä, J.K. Järvinen, T. Karimäki, V. Kinnunen, R. Lampén, T. Lassila-Perini, K. Laurila, S. Lehti, S. Lindén, T. Luukka, P. Mäenpää, T. Siikonen, H. Tuominen, E. Tuominiemi, J. Tuuva, T. Besancon, M. Couderc, F. Dejardin, M. Denegri, D. Faure, J.L. Ferri, F. Ganjour, S. Ghosh, S. Givernaud, A. Gras, P. de Monchenault, G.H. Jarry, P. Leloup, C. Locci, E. Machet, M. Malcles, J. Negro, G. Rander, J. Rosowsky, A. Sahin, M.Ö. Titov, M. Abdulsalam, A. Amendola, C. Antropov, I. Baffioni, S. Beaudette, F. Busson, P. Cadamuro, L. Charlot, C. de Cassagnac, R.G. Jo, M. Kucher, I. Lisniak, S. Lobanov, A. Blanco, J.M. Nguyen, M. Ochando, C. Ortona, G. Paganini, P. Pigard, P. Salerno, R. Sauvan, J.B. Sirois, Y. Leiton, A.G.S. Yilmaz, Y. Zabi, A. Zghiche, A. Agram, J.-L. Andrea, J. Bloch, D. Brom, J.-M. Chabert, E.C. Collard, C. Conte, E. Coubez, X. Drouhin, F. Fontaine, J.-C. Gelé, D. Goerlach, U. Jansová, M. Juillot, P. Bihan, A.-C.L. Tonon, N. Hove, P.V. Gadrat, S. Beauceron, S. Bernet, C. Boudoul, G. Chanon, N. Chierici, R. Contardo, D. Depasse, P. Mamouni, H.E. Fay, J. Finco, L. Gascon, S. Gouzevitch, M. Grenier, G. Ille, B. Lagarde, F. Laktineh, I.B. Lattaud, H. Lethuillier, M. Mirabito, L. Pequegnot, A.L. Perries, S. Popov, A. Sordini, V. Donckt, M.V. Viret, S. Zhang, S. Toriashvili, T. Tsamalaidze, Z. Autermann, C. Feld, L. Kiesel, M.K. Klein, K. Lipinski, M. Preuten, M. Rauch, M.P. Schomakers, C. Schulz, J. Teroerde, M. Wittmer, B. Zhukov, V. Albert, A. Duchardt, D. Endres, M. Erdmann, M. Erdweg, S. Esch, T. Fischer, R. Güth, A. Hebbeker, T. Heidemann, C. Hoepfner, K. Knutzen, S. Merschmeyer, M. Meyer, A. Millet, P. Mukherjee, S. Pook, T. Radziej, M. Reithler, H. Rieger, M. Scheuch, F. Teyssier, D. Thüer, S. Flügge, G. Kargoll, B. Kress, T. Künsken, A. Müller, T. Nehrkorn, A. Nowack, A. Pistone, C. Pooth, O. Stahl, A. Martin, M.A. Arndt, T. Asawatangtrakuldee, C. Beernaert, K. Behnke, O. Behrens, U. Martínez, A.B. Anuar, A.A.B. Borras, K. Botta, V. Campbell, A. Connor, P. Contreras-Campana, C. Costanza, F. Danilov, V. De Wit, A. Pardos, C.D. Damiani, D.D. Eckerlin, G. Eckstein, D. Eichhorn, T. Elwood, A. Eren, E. Gallo, E. Garcia, J.G. Geiser, A. Luyando, J.M.G. Grohsjean, A. Gunnellini, P. Guthoff, M. Harb, A. Hauk, J. Hempel, M. Jung, H. Kasemann, M. Keaveney, J. Kleinwort, C. Knolle, J. Korol, I. Krücker, D. Lange, W. Lelek, A. Lenz, T. Lipka, K. Lohmann, W. Mankel, R. Melzer-Pellmann, I.-A. Meyer, A.B. Meyer, M. Missiroli, M. Mittag, G. Mnich, J. Mussgiller, A. Pitzl, D. Raspereza, A. Savitskyi, M. Saxena, P. Shevchenko, R. Stefaniuk, N. Tholen, H. Onsem, G.P.V. Walsh, R. Wen, Y. Wichmann, K. Wissing, C. Zenaiev, O. Aggleton, R. Bein, S. Blobel, V. Vignali, M.C. Dreyer, T. Garutti, E. Gonzalez, D. Haller, J. Hinzmann, A. Hoffmann, M. Karavdina, A. Kasieczka, G. Klanner, R. Kogler, R. Kovalchuk, N. Kurz, S. Kutzner, V. Lange, J. Marconi, D. Multhaup, J. Niedziela, M. Nowatschin, D. Peiffer, T. Perieanu, A. Reimers, A. Scharf, C. Schleper, P. Schmidt, A. Schumann, S. Schwandt, J. Sonneveld, J. Stadie, H. Steinbrück, G. Stober, F.M. Stöver, M. Troendle, D. Usai, E. Vanhoefer, A. Vormwald, B. Akbiyik, M. Barth, C. Baselga, M. Baur, S. Butz, E. Caspart, R. Chwalek, T. Colombo, F. De Boer, W. Dierlamm, A. Faltermann, N. Freund, B. Friese, R. Giffels, M. Harrendorf, M.A. Hartmann, F. Heindl, S.M. Husemann, U. Kassel, F. Kudella, S. Mildner, H. Mozer, M.U. Müller, T. Plagge, M. Quast, G. Rabbertz, K. Schröder, M. Shvetsov, I. Sieber, G. Simonis, H.J. Ulrich, R. Wayand, S. Weber, M. Weiler, T. Williamson, S. Wöhrmann, C. Wolf, R. Anagnostou, G. Daskalakis, G. Geralis, T. Kyriakis, A. Loukas, D. Topsis-Giotis, I. Karathanasis, G. Kesisoglou, S. Panagiotou, A. Saoulidou, N. Tziaferi, E. Kousouris, K. Papakrivopoulos, I. Evangelou, I. Foudas, C. Gianneios, P. Katsoulis, P. Kokkas, P. Mallios, S. Manthos, N. Papadopoulos, I. Paradas, E. Strologas, J. Triantis, F.A. Tsitsonis, D. Csanad, M. Filipovic, N. Pasztor, G. Surányi, O. Veres, G.I. Bencze, G. Hajdu, C. Horvath, D. Hunyadi, Á. Sikler, F. Vámi, T.Á. Veszpremi, V. Vesztergombi, G. Beni, N. Czellar, S. Karancsi, J. Makovec, A. Molnar, J. Szillasi, Z. Bartók, M. Raics, P. Trocsanyi, Z.L. Ujvari, B. Choudhury, S. Komaragiri, J.R. Bahinipati, S. Mal, P. Mandal, K. Nayak, A. Sahoo, D.K. Swain, S.K. Bansal, S. Beri, S.B. Bhatnagar, V. Chauhan, S. Chawla, R. Dhingra, N. Gupta, R. Kaur, A. Kaur, M. Kaur, S. Kumar, R. Kumari, P. Lohan, M. Mehta, A. Sharma, S. Singh, J.B. Walia, G. Bhardwaj, A. Choudhary, B.C. Garg, R.B. Keshri, S. Kumar, A. Kumar, A. Malhotra, S. Naimuddin, M. Ranjan, K. Shah, A. Sharma, R. Bhardwaj, R. Bhattacharya, R. Bhattacharya, S. Bhawandeep, U. Bhowmik, D. Dey, S. Dutt, S. Dutta, S. Ghosh, S. Majumdar, N. Mondal, K. Mukhopadhyay, S. Nandan, S. Purohit, A. Rout, P.K. Roy, A. Chowdhury, S.R. Sarkar, S. Sharan, M. Singh, B. Thakur, S. Behera, P.K. Chudasama, R. Dutta, D. Jha, V. Kumar, V. Mohanty, A.K. Netrakanti, P.K. Pant, L.M. Shukla, P. Topkar, A. Aziz, T. Dugad, S. Mahakud, B. Mitra, S. Mohanty, G.B. Sur, N. Sutar, B. Banerjee, S. Bhattacharya, S. Chatterjee, S. Das, P. Guchait, M. Jain, S. Kumar, S. Maity, M. Majumder, G. Mazumdar, K. Sahoo, N. Sarkar, T. Wickramage, N. Chauhan, S. Dube, S. Hegde, V. Kapoor, A. Kothekar, K. Pandey, S. Rane, A. Sharma, S. Chenarani, S. Tadavani, E.E. Etesami, S.M. Khakzad, M. Najafabadi, M.M. Naseri, M. Mehdiabadi, S.P. Hosseinabadi, F.R. Safarzadeh, B. Zeinali, M. Felcini, M. Grunewald, M. Abbrescia, M. Calabria, C. Colaleo, A. Creanza, D. Cristella, L. De Filippis, N. De Palma, M. Florio, A.D. Errico, F. Fiore, L. Gelmi, A. Iaselli, G. Lezki, S. Maggi, G. Maggi, M. Marangelli, B. Miniello, G. My, S. Nuzzo, S. Pompili, A. Pugliese, G. Radogna, R. Ranieri, A. Selvaggi, G. Sharma, A. Silvestris, L. Venditti, R. Verwilligen, P. Zito, G. Abbiendi, G. Battilana, C. Bonacorsi, D. Borgonovi, L. Braibant-Giacomelli, S. Campanini, R. Capiluppi, P. Castro, A. Cavallo, F.R. Chhibra, S.S. Codispoti, G. Cuffiani, M. Dallavalle, G.M. Fabbri, F. Fanfani, A. Fasanella, D. Giacomelli, P. Grandi, C. Guiducci, L. Marcellini, S. Masetti, G. Montanari, A. Navarria, F.L. Odorici, F. Perrotta, A. Rossi, A.M. Rovelli, T. Siroli, G.P. Tosi, N. Albergo, S. Costa, S. Mattia, A.D. Giordano, F. Potenza, R. Tricomi, A. Tuve, C. Barbagli, G. Chatterjee, K. Ciulli, V. Civinini, C. D’Alessandro, R. Focardi, E. Latino, G. Lenzi, P. Meschini, M. Paoletti, S. Russo, L. Sguazzoni, G. Strom, D. Viliani, L. Benussi, L. Bianco, S. Fabbri, F. Piccolo, D. Primavera, F. Calvelli, V. Ferro, F. Ravera, F. Robutti, E. Tosi, S. Benaglia, A. Beschi, A. Brianza, L. Brivio, F. Ciriolo, V. Dinardo, M.E. Fiorendi, S. Gennai, S. Ghezzi, A. Govoni, P. Malberti, M. Malvezzi, S. Manzoni, R.A. Menasce, D. Moroni, L. Paganoni, M. Pauwels, K. Pedrini, D. Pigazzini, S. Ragazzi, S. de Fatis, T.T. Buontempo, S. Cavallo, N. Guida, S.D. Fabozzi, F. Fienga, F. Galati, G. Iorio, A.O.M. Khan, W.A. Lista, L. Meola, S. Paolucci, P. Sciacca, C. Thyssen, F. Voevodina, E. Azzi, P. Bacchetta, N. Benato, L. Bisello, D. Boletti, A. Carlin, R. De Oliveira, A.C.A. Checchia, P. De Castro Manzano, P. Dorigo, T. Dosselli, U. Gasparini, F. Gasparini, U. Gozzelino, A. Lacaprara, S. Lujan, P. Margoni, M. Meneguzzo, A.T. Pozzobon, N. Ronchese, P. Rossin, R. Simonetto, F. Tiko, A. Zanetti, M. Zotto, P. Zumerle, G. Braghieri, A. Magnani, A. Montagna, P. Ratti, S.P. Re, V. Ressegotti, M. Riccardi, C. Salvini, P. Vai, I. Vitulo, P. Solestizi, L.A. Biasini, M. Bilei, G.M. Cecchi, C. Ciangottini, D. Fanò, L. Lariccia, P. Leonardi, R. Manoni, E. Mantovani, G. Mariani, V. Menichelli, M. Rossi, A. Santocchia, A. Spiga, D. Androsov, K. Azzurri, P. Bagliesi, G. Bianchini, L. Boccali, T. Borrello, L. Castaldi, R. Ciocci, M.A. Dell’Orso, R. Fedi, G. Giannini, L. Giassi, A. Grippo, M.T. Ligabue, F. Lomtadze, T. Manca, E. Mandorli, G. Messineo, A. Palla, F. Rizzi, A. Spagnolo, P. Tenchini, R. Tonelli, G. Venturi, A. Verdini, P.G. Barone, L. Cavallari, F. Cipriani, M. Daci, N. Re, D.D. Marco, E.D. Diemoz, M. Gelli, S. Longo, E. Marzocchi, B. Meridiani, P. Organtini, G. Pandolfi, F. Paramatti, R. Preiato, F. Rahatlou, S. Rovelli, C. Santanastasio, F. Amapane, N. Arcidiacono, R. Argiro, S. Arneodo, M. Bartosik, N. Bellan, R. Biino, C. Cartiglia, N. Castello, R. Cenna, F. Costa, M. Covarelli, R. Degano, A. Demaria, N. Kiani, B. Mariotti, C. Maselli, S. Migliore, E. Monaco, V. Monteil, E. Monteno, M. Obertino, M.M. Pacher, L. Pastrone, N. Pelliccioni, M. Angioni, G.L.P. Romero, A. Ruspa, M. Sacchi, R. Shchelina, K. Sola, V. Solano, A. Staiano, A. Belforte, S. Casarsa, M. Cossutti, F. Ricca, G.D. Zanetti, A. Kim, D.H. Kim, G.N. Kim, M.S. Lee, J. Lee, S. Lee, S.W. Moon, C.S. Oh, Y.D. Sekmen, S. Son, D.C. Yang, Y.C. Kim, H. Moon, D.H. Oh, G. Cifuentes, J.A.B. Goh, J. Kim, T.J. Cho, S. Choi, S. Go, Y. Gyun, D. Ha, S. Hong, B. Jo, Y. Kim, Y. Lee, K. Lee, K.S. Lee, S. Lim, J. Park, S.K. Roh, Y. Almond, J. Kim, J. Kim, J.S. Lee, H. Lee, K. Nam, K. Oh, S.B. Radburn-Smith, B.C. Seo, S. Yang, U.K. Yoo, H.D. Yu, G.B. Kim, H. Kim, J.H. Lee, J.S.H. Park, I.C. Choi, Y. Hwang, C. Lee, J. Yu, I. Dudenas, V. Juodagalvis, A. Vaitkus, J. Ahmed, I. Ibrahim, Z.A. Ali, M.A.B.M. Idris, F.M. Abdullah, W.A.T.W. Yusli, M.N. Zolkapli, Z. Castilla-Valdez, H. De La Cruz-Burelo, E. Duran-Osuna, M.C. La Cruz, I.H.-D. Lopez-Fernandez, R. Guisao, J.M. Rabadan-Trejo, R.I. Ramirez-Sanchez, G. Reyes-Almanza, R. Sanchez-Hernandez, A. Moreno, S.C. Barrera, C.O. Valencia, F.V. Eysermans, J. Pedraza, I. Ibarguen, H.A.S. Estrada, C.U. Pineda, A.M. Krofcheck, D. Bheesette, S. Butler, P.H. Ahmad, A. Ahmad, M. Hassan, Q. Hoorani, H.R. Saddique, A. Shah, M.A. Shoaib, M. Waqas, M. Bialkowska, H. Bluj, M. Boimska, B. Frueboes, T. Górski, M. Kazana, M. Nawrocki, K. Szleper, M. Traczyk, P. Zalewski, P. Bunkowski, K. Byszuk, A. Doroba, K. Kalinowski, A. Konecki, M. Krolikowski, J. Misiura, M. Olszewski, M. Pyskir, A. Walczak, M. Bargassa, P. Da Cruz E Silva, C.B. Francesco, A.D. Faccioli, P. Galinhas, B. Gallinaro, M. Hollar, J. Leonardo, N. Iglesias, L.L. Nemallapudi, M.V. Seixas, J. Strong, G. Toldaiev, O. Vadruccio, D. Varela, J. Afanasiev, S. Bunin, P. Gavrilenko, M. Golutvin, I. Gorbunov, I. Kamenev, A. Karjavin, V. Lanev, A. Malakhov, A. Matveev, V. Moisenz, P. Palichik, V. Perelygin, V. Shmatov, S. Shulha, S. Skatchkov, N. Smirnov, V. Voytishin, N. Zarubin, A. Ivanov, Y. Kim, V. Kuznetsova, E. Levchenko, P. Murzin, V. Oreshkin, V. Smirnov, I. Sosnov, D. Sulimov, V. Uvarov, L. Vavilov, S. Vorobyev, A. Andreev, Y. Dermenev, A. Gninenko, S. Golubev, N. Karneyeu, A. Kirsanov, M. Krasnikov, N. Pashenkov, A. Tlisov, D. Toropin, A. Epshteyn, V. Gavrilov, V. Lychkovskaya, N. Popov, V. Pozdnyakov, I. Safronov, G. Spiridonov, A. Stepennov, A. Stolin, V. Toms, M. Vlasov, E. Zhokin, A. Aushev, T. Bylinkin, A. Andreev, V. Azarkin, M. Dremin, I. Kirakosyan, M. Rusakov, S.V. Terkulov, A. Baskakov, A. Belyaev, A. Boos, E. Ershov, A. Gribushin, A. Khein, L. Klyukhin, V. Kodolova, O. Lokhtin, I. Lukina, O. Miagkov, I. Obraztsov, S. Petrushanko, S. Savrin, V. Snigirev, A. Blinov, V. Shtol, D. Skovpen, Y. Azhgirey, I. Bayshev, I. Bitioukov, S. Elumakhov, D. Godizov, A. Kachanov, V. Kalinin, A. Konstantinov, D. Mandrik, P. Petrov, V. Ryutin, R. Sobol, A. Troshin, S. Tyurin, N. Uzunian, A. Volkov, A. Babaev, A. Adzic, P. Cirkovic, P. Devetak, D. Dordevic, M. Milosevic, J. Maestre, J.A. Fernández, A.Á. Bachiller, I. Luna, M.B. Cerrada, M. Colino, N. De La Cruz, B. Peris, A.D. Bedoya, C.F. Ramos, J.P.F. Flix, J. Fouz, M.C. Lopez, O.G. Lopez, S.G. Hernandez, J.M. Josa, M.I. Moran, D. Yzquierdo, A.P.-C. Pelayo, J.P. Redondo, I. Romero, L. Soares, M.S. Triossi, A. Albajar, C. de Trocóniz, J.F. Cuevas, J. Erice, C. Menendez, J.F. Folgueras, S. Caballero, I.G. Fernández, J.R.G. Cortezon, E.P. Cruz, S.S. Vischia, P. Garcia, J.M.V. Cabrillo, I.J. Calderon, A. Quero, B.C. Campderros, J.D. Fernandez, M. Manteca, P.J.F. Alonso, A.G. Garcia-Ferrero, J. Gomez, G. Virto, A.L. Marco, J. Rivero, C.M. Arbol, P.M.R. Matorras, F. Gomez, J.P. Prieels, C. Rodrigo, T. Ruiz-Jimeno, A. Scodellaro, L. Trevisani, N. Vila, I. Cortabitarte, R.V. Abbaneo, D. Akgun, B. Auffray, E. Baillon, P. Ball, A.H. Barney, D. Bendavid, J. Bianco, M. Bocci, A. Botta, C. Camporesi, T. Cepeda, M. Cerminara, G. Chapon, E. Chen, Y. d’Enterria, D. Dabrowski, A. Daponte, V. David, A. De Gruttola, M. De Roeck, A. Deelen, N. Dobson, M. Pree, T. Dünser, M. Dupont, N. Elliott-Peisert, A. Everaerts, P. Fallavollita, F. Franzoni, G. Fulcher, J. Funk, W. Gigi, D. Gilbert, A. Gill, K. Glege, F. Gulhan, D. Hegeman, J. Innocente, V. Jafari, A. Janot, P. Karacheban, O. Kieseler, J. Knünz, V. Kornmayer, A. Krammer, M. Lange, C. Lecoq, P. 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Pesaresi, M. Richards, A. Rose, A. Scott, E. Seez, C. Shtipliyski, A. Strebler, T. Summers, S. Tapper, A. Uchida, K. Acosta, M.V. Virdee, T. Wardle, N. Winterbottom, D. Wright, J. Zenz, S.C. Cole, J.E. Hobson, P.R. Khan, A. Kyberd, P. Morton, A. Reid, I.D. Teodorescu, L. Zahid, S. Borzou, A. Call, K. Dittmann, J. Hatakeyama, K. Liu, H. Pastika, N. Smith, C. Bartek, R. Dominguez, A. Buccilli, A. Cooper, S.I. Henderson, C. Rumerio, P. West, C. Arcaro, D. Avetisyan, A. Bose, T. Gastler, D. Rankin, D. Richardson, C. Rohlf, J. Sulak, L. Zou, D. Benelli, G. Cutts, D. Hadley, M. Hakala, J. Heintz, U. Hogan, J.M. Kwok, K.H.M. Laird, E. Landsberg, G. Lee, J. Mao, Z. Narain, M. Pazzini, J. Piperov, S. Sagir, S. Syarif, R. Yu, D. Band, R. Brainerd, C. Breedon, R. Burns, D. De La Barca Sanchez, M.C. Chertok, M. Conway, J. Conway, R. Cox, P.T. Erbacher, R. Flores, C. Funk, G. Ko, W. Lander, R. Mclean, C. Mulhearn, M. Pellett, D. Pilot, J. Shalhout, S. Shi, M. Smith, J. Stolp, D. Taylor, D. Tos, K. Tripathi, M. Wang, Z. Zhang, F. Bachtis, M. Bravo, C. Cousins, R. Dasgupta, A. Florent, A. Hauser, J. Ignatenko, M. Mccoll, N. Regnard, S. Saltzberg, D. Schnaible, C. Valuev, V. Bouvier, E. Burt, K. Clare, R. Ellison, J. Gary, J.W. Shirazi, S.M.A.G. Hanson, G. Karapostoli, G. Kennedy, E. Lacroix, F. Long, O.R. Negrete, M.O. Paneva, M.I. Si, W. Wang, L. Wei, H. Wimpenny, S. Yates, B.R. Branson, J.G. Cittolin, S. Derdzinski, M. Gerosa, R. Gilbert, D. Hashemi, B. Holzner, A. Klein, D. Kole, G. Krutelyov, V. Letts, J. Masciovecchio, M. Olivito, D. Padhi, S. Pieri, M. Sani, M. Sharma, V. Simon, S. Tadel, M. Vartak, A. Wasserbaech, S. Wood, J. Würthwein, F. Yagil, A. Porta, G.Z.D. Amin, N. Bhandari, R. Bradmiller-Feld, J. Campagnari, C. Citron, M. Dishaw, A. Dutta, V. Sevilla, M.F. Gouskos, L. Heller, R. Incandela, J. Ovcharova, A. Qu, H. Richman, J. Stuart, D. Suarez, I. Yoo, J. Anderson, D. Bornheim, A. Bunn, J. Lawhorn, J.M. Newman, H.B. Nguyen, T.Q. Pena, C. Spiropulu, M. Vlimant, J.R. Wilkinson, R. Xie, S. Zhang, Z. Zhu, R.Y. Andrews, M.B. Ferguson, T. Mudholkar, T. Paulini, M. Russ, J. Sun, M. Vogel, H. Vorobiev, I. Weinberg, M. Cumalat, J.P. Ford, W.T. Jensen, F. Johnson, A. Krohn, M. Leontsinis, S. MacDonald, E. Mulholland, T. Stenson, K. Ulmer, K.A. Wagner, S.R. Alexander, J. Chaves, J. Cheng, Y. Chu, J. Datta, A. Mcdermott, K. Mirman, N. Patterson, J.R. Quach, D. Rinkevicius, A. Ryd, A. Skinnari, L. Soffi, L. Tan, S.M. Tao, Z. Thom, J. Tucker, J. Wittich, P. Zientek, M. Abdullin, S. Albrow, M. Alyari, M. Apollinari, G. Apresyan, A. Apyan, A. Banerjee, S. Bauerdick, L.A.T. Beretvas, A. Berryhill, J. Bhat, P.C. Bolla, G. Burkett, K. Butler, J.N. Canepa, A. Cerati, G.B. Cheung, H.W.K. Chlebana, F. Cremonesi, M. Duarte, J. Elvira, V.D. Freeman, J. Gecse, Z. Gottschalk, E. Gray, L. Green, D. Grünendahl, S. Gutsche, O. Hanlon, J. Harris, R.M. Hasegawa, S. Hirschauer, J. Hu, Z. Jayatilaka, B. Jindariani, S. Johnson, M. Joshi, U. Klima, B. Kortelainen, M.J. Kreis, B. Lammel, S. Lincoln, D. Lipton, R. Liu, M. Liu, T. De Sá, R.L. Lykken, J. Maeshima, K. Magini, N. Marraffino, J.M. Mason, D. McBride, P. Merkel, P. Mrenna, S. Nahn, S. O’Dell, V. Pedro, K. Prokofyev, O. Rakness, G. Ristori, L. Savoy-Navarro, A. Schneider, B. Sexton-Kennedy, E. Soha, A. Spalding, W.J. Spiegel, L. Stoynev, S. Strait, J. Strobbe, N. Taylor, L. Tkaczyk, S. Tran, N.V. Uplegger, L. Vaandering, E.W. Vernieri, C. Verzocchi, M. Vidal, R. Wang, M. Weber, H.A. Whitbeck, A. Wu, W. Acosta, D. Avery, P. Bortignon, P. Bourilkov, D. Brinkerhoff, A. Carnes, A. Carver, M. Curry, D. Field, R.D. Furic, I.K. Gleyzer, S.V. Joshi, B.M. Konigsberg, J. Korytov, A. Kotov, K. Ma, P. Matchev, K. Mei, H. Mitselmakher, G. Shi, K. Sperka, D. Terentyev, N. Thomas, L. Wang, J. Wang, S. Yelton, J. Joshi, Y.R. Linn, S. Markowitz, P. Rodriguez, J.L. Ackert, A. Adams, T. Askew, A. Hagopian, S. Hagopian, V. Johnson, K.F. Kolberg, T. Martinez, G. Perry, T. Prosper, H. Saha, A. Santra, A. Sharma, V. Yohay, R. Baarmand, M.M. Bhopatkar, V. Colafranceschi, S. Hohlmann, M. Noonan, D. Roy, T. Yumiceva, F. Adams, M.R. Apanasevich, L. Berry, D. Betts, R.R. Cavanaugh, R. Chen, X. Dittmer, S. Evdokimov, O. Gerber, C.E. Hangal, D.A. Hofman, D.J. Jung, K. Kamin, J. Gonzalez, I.D.S. Tonjes, M.B. Varelas, N. Wang, H. Wu, Z. Zhang, J. Bilki, B. Clarida, W. Dilsiz, K. Durgut, S. Gandrajula, R.P. Haytmyradov, M. Khristenko, V. Merlo, J.-P. Mermerkaya, H. Mestvirishvili, A. Moeller, A. Nachtman, J. Ogul, H. Onel, Y. Ozok, F. Penzo, A. Snyder, C. Tiras, E. Wetzel, J. Yi, K. Blumenfeld, B. Cocoros, A. Eminizer, N. Fehling, D. Feng, L. Gritsan, A.V. Hung, W.T. Maksimovic, P. Roskes, J. Sarica, U. Swartz, M. Xiao, M. You, C. Al-bataineh, A. Baringer, P. Bean, A. Boren, S. Bowen, J. Castle, J. Khalil, S. Kropivnitskaya, A. Majumder, D. Mcbrayer, W. Murray, M. Rogan, C. Royon, C. Sanders, S. Schmitz, E. Takaki, J.D.T. Wang, Q. Ivanov, A. Kaadze, K. Maravin, Y. Modak, A. Mohammadi, A. Saini, L.K. Skhirtladze, N. Rebassoo, F. Wright, D. Baden, A. Baron, O. Belloni, A. Eno, S.C. Feng, Y. Ferraioli, C. Hadley, N.J. Jabeen, S. Jeng, G.Y. Kellogg, R.G. Kunkle, J. Mignerey, A.C. Ricci-Tam, F. Shin, Y.H. Skuja, A. Tonwar, S.C. Abercrombie, D. Allen, B. Azzolini, V. Barbieri, R. Baty, A. Bauer, G. Bi, R. Brandt, S. Busza, W. Cali, I.A. D’Alfonso, M. Demiragli, Z. Ceballos, G.G. Goncharov, M. Harris, P. Hsu, D. Hu, M. Iiyama, Y. Innocenti, G.M. Klute, M. Kovalskyi, D. Lee, Y.-J. Levin, A. Luckey, P.D. Maier, B. Marini, A.C. Mcginn, C. Mironov, C. Narayanan, S. Niu, X. Paus, C. Roland, C. Roland, G. Stephans, G.S.F. Sumorok, K. Tatar, K. Velicanu, D. Wang, J. Wang, T.W. Wyslouch, B. Zhaozhong, S. Benvenuti, A.C. Chatterjee, R.M. Evans, A. Hansen, P. Kalafut, S. Kubota, Y. Lesko, Z. Mans, J. Nourbakhsh, S. Ruckstuhl, N. Rusack, R. Turkewitz, J. Wadud, M.A. Acosta, J.G. Oliveros, S. Avdeeva, E. Bloom, K. Claes, D.R. Fangmeier, C. Golf, F. Suarez, R.G. Kamalieddin, R. Kravchenko, I. Monroy, J. Siado, J.E. Snow, G.R. Stieger, B. Godshalk, A. Harrington, C. Iashvili, I. Nguyen, D. Parker, A. Rappoccio, S. Roozbahani, B. Alverson, G. Barberis, E. Freer, C. Hortiangtham, A. Massironi, A. Morse, D.M. Orimoto, T. De Lima, R.T. Wamorkar, T. Wang, B. Wisecarver, A. Wood, D. Bhattacharya, S. Charaf, O. Hahn, K.A. Mucia, N. Odell, N. Schmitt, M.H. Sung, K. Trovato, M. Velasco, M. Bucci, R. Dev, N. Hildreth, M. Anampa, K.H. Jessop, C. Karmgard, D.J. Kellams, N. Lannon, K. Li, W. Loukas, N. Marinelli, N. Meng, F. Mueller, C. Musienko, Y. Planer, M. Reinsvold, A. Ruchti, R. Siddireddy, P. Smith, G. Taroni, S. Wayne, M. Wightman, A. Wolf, M. Woodard, A. Alimena, J. Antonelli, L. Bylsma, B. Durkin, L.S. Flowers, S. Francis, B. Hart, A. Hill, C. Ji, W. Ling, T.Y. Luo, W. Winer, B.L. Wulsin, H.W. Cooperstein, S. Driga, O. Elmer, P. Hardenbrook, J. Hebda, P. Higginbotham, S. Kalogeropoulos, A. Lange, D. Luo, J. Marlow, D. Mei, K. Ojalvo, I. Olsen, J. Palmer, C. Piroué, P. Salfeld-Nebgen, J. Stickland, D. Tully, C. Malik, S. Norberg, S. Barker, A. Barnes, V.E. Das, S. Gutay, L. Jones, M. Jung, A.W. Khatiwada, A. Miller, D.H. Neumeister, N. Peng, C.C. Qiu, H. Schulte, J.F. Sun, J. Wang, F. Xiao, R. Xie, W. Cheng, T. Dolen, J. Parashar, N. Chen, Z. Ecklund, K.M. Freed, S. Geurts, F.J.M. Guilbaud, M. Kilpatrick, M. Li, W. Michlin, B. Padley, B.P. Roberts, J. Rorie, J. Shi, W. Tu, Z. Zabel, J. Zhang, A. Bodek, A. de Barbaro, P. Demina, R. Duh, Y. Ferbel, T. Galanti, M. Garcia-Bellido, A. Han, J. Hindrichs, O. Khukhunaishvili, A. Lo, K.H. Tan, P. Verzetti, M. Ciesielski, R. Goulianos, K. Mesropian, C. Agapitos, A. Chou, J.P. Gershtein, Y. Espinosa, T.A.G. Halkiadakis, E. Heindl, M. Hughes, E. Kaplan, S. Elayavalli, R.K. Kyriacou, S. Lath, A. Montalvo, R. Nash, K. Osherson, M. Saka, H. Salur, S. Schnetzer, S. Sheffield, D. Somalwar, S. Stone, R. Thomas, S. Thomassen, P. Walker, M. Delannoy, A.G. Heideman, J. Riley, G. Rose, K. Spanier, S. Thapa, K. Bouhali, O. Hernandez, A.C. Celik, A. Dalchenko, M. De Mattia, M. Delgado, A. Dildick, S. Eusebi, R. Gilmore, J. Huang, T. Kamon, T. Mueller, R. Pakhotin, Y. Patel, R. Perloff, A. Perniè, L. Rathjens, D. Safonov, A. Tatarinov, A. Akchurin, N. Damgov, J. De Guio, F. Dudero, P.R. Faulkner, J. Gurpinar, E. Kunori, S. Lamichhane, K. Lee, S.W. Mengke, T. Muthumuni, S. Peltola, T. Undleeb, S. Volobouev, I. Wang, Z. Greene, S. Gurrola, A. Janjam, R. Johns, W. Maguire, C. Melo, A. Ni, H. Padeken, K. Alvarez, J.D.R. Sheldon, P. Tuo, S. Velkovska, J. Xu, Q. Arenton, M.W. Barria, P. Cox, B. Hirosky, R. Joyce, M. Ledovskoy, A. Li, H. Neu, C. Sinthuprasith, T. Wang, Y. Wolfe, E. Xia, F. Harr, R. Karchin, P.E. Poudyal, N. Sturdy, J. Thapa, P. Zaleski, S. Brodski, M. Buchanan, J. Caillol, C. Carlsmith, D. Dasu, S. Dodd, L. Duric, S. Gomber, B. Grothe, M. Herndon, M. Hervé, A. Hussain, U. Klabbers, P. Lanaro, A. Levine, A. Long, K. Loveless, R. Rekovic, V. Ruggles, T. Savin, A. Smith, N. Smith, W.H. Woods, N. CMS Collaboration

Abstract

In this article the author name Luigi Calligaris was incorrectly written as A. Calligaris. The original article has been corrected. © CERN for the benefit of the CMS collaboration 2022.

Published
2022

41. The RTM harmonic correction revisited

Author

R. Klees, K. Seitz, and D. C. Slobbe

Subjects
Earth sciences, Geophysics, Harmonic correction, Geochemistry and Petrology, Least-squares collocation, ddc:550, Computers in Earth Sciences, RTM correction, Quasi-geoid modelling, Least-squares
Abstract

In this paper, we derive improved expressions for the harmonic correction to gravity and, for the first time, expressions for the harmonic correction to potential and height anomaly. They need to be applied at stations buried inside the masses to transform internal values into harmonically downward continued values, which are then input to local quasi-geoid modelling using least-squares collocation or least-squares techniques in combination with the remove-compute-restore approach. Harmonic corrections to potential and height anomaly were assumed to be negligible so far resulting in yet unknown quasi-geoid model errors. The improved expressions for the harmonic correction to gravity, and the new expressions for the harmonic correction to potential and height anomaly are used to quantify the approximation errors of the commonly used harmonic correction to gravity and to quantify the magnitude of the harmonic correction to potential and height anomaly. This is done for two test areas with different topographic regimes. One comprises parts of Norway and the North Atlantic where the presence of deep, long, and narrow fjords suggest extreme values for the harmonic correction to potential and height anomaly and corresponding large errors of the commonly used approximation of the harmonic correction to gravity. The other one is located in the Auvergne test area with a moderate topography comprising both flat and hilly areas and therefore may be representative for many areas around the world. For both test areas, two RTM surfaces with different smoothness are computed simulating the use of a medium-resolution and an ultra-high-resolution reference gravity field, respectively. We show that the errors of the commonly used harmonic correction to gravity may be as large as the harmonic correction itself and attain peak values in areas of strong topographic variations of about 100 mGal. Moreover, we show that this correction may introduce long-wavelength biases in the computed quasi-geoid model. Furthermore, we show that the harmonic correction to height anomaly can attain values on the order of a decimetre at some points. Overall, however, the harmonic correction to height anomaly needs to be applied only in areas of strong topographic variations. In flat or hilly areas, it is mostly smaller than one centimetre. Finally, we show that the harmonic corrections increase with increasing smoothness of the RTM surface, which suggests to use a RTM surface with a spatial resolution comparable to the finest scales which can be resolved by the data rather than depending on the resolution of the global geopotential model used to reduce the data.

Published
2022

42. Changing Threshold-Based Segmentation Has No Relevant Impact on Semi-Quantification in the Context of Structured Reporting for PSMA-PET/CT

Author

Patrick W. Mihatsch, Matthias Beissert, Martin G. Pomper, Thorsten A. Bley, Anna K. Seitz, Hubert Kübler, Andreas K. Buck, Steven P. Rowe, Sebastian E. Serfling, Philipp E. Hartrampf, and Rudolf A. Werner

Subjects
Cancer Research, PET/CT, 18F-PSMA-1007, standardized reporting system, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, PSMA-RADS, staging, urologic and male genital diseases, prostate cancer, Article, Oncology, ddc:610, RC254-282
Abstract

Simple Summary Molecular imaging of patients with prostate cancer is widely utilized. We aimed to determine whether changes in post-processing parameters, such as maximum intensity thresholds, can significantly alter results. We investigated 623 lesions that were positive on a molecular imaging scan and could not find any relevant impact on results when certain parameters were changed, in particular in lesions indicative for metastases of prostate cancer. Abstract Prostate-specific membrane antigen (PSMA)-directed positron emission tomography/computed tomography (PET/CT) is increasingly utilized for staging of men with prostate cancer (PC). To increase interpretive certainty, the standardized PSMA reporting and data system (RADS) has been proposed. Using PSMA-RADS, we characterized lesions in 18 patients imaged with 18F-PSMA-1007 PET/CT for primary staging and determined the stability of semi-quantitative parameters. Six hundred twenty-three lesions were categorized according to PSMA-RADS and manually segmented. In this context, PSMA-RADS-3A (soft-tissue) or -3B (bone) lesions are defined as being indeterminate for the presence of PC. For PMSA-RADS-4 and -5 lesions; however, PC is highly likely or almost certainly present [with further distinction based on absence (PSMA-RADS-4) or presence (PSMA-RADS-5) of correlative findings on CT]. Standardized uptake values (SUVmax, SUVpeak, SUVmean) were recorded, and volumetric parameters [PSMA-derived tumor volume (PSMA-TV); total lesion PSMA (TL-PSMA)] were determined using different maximum intensity thresholds (MIT) (40 vs. 45 vs. 50%). SUVmax was significantly higher in PSMA-RADS-5 lesions compared to all other PSMA-RADS categories (p ≤ 0.0322). In particular, the clinically challenging PSMA-RADS-3A lesions showed significantly lower SUVmax and SUVpeak compared to the entire PSMA-RADS-4 or -5 cohort (p < 0.0001), while for PSMA-RADS-3B this only applies when compared to the entire PSMA-RADS-5 cohort (p < 0.0001), but not to the PSMA-RADS-4 cohort (SUVmax, p = 0.07; SUVpeak, p = 0.08). SUVmean (p = 0.30) and TL-PSMA (p = 0.16) in PSMA-RADS-5 lesions were not influenced by changing the MIT, while PSMA-TV showed significant differences when comparing 40 vs. 50% MIT (p = 0.0066), which was driven by lymph nodes (p = 0.0239), but not bone lesions (p = 0.15). SUVmax was significantly higher in PSMA-RADS-5 lesions compared to all other PSMA-RADS categories in 18F-PSMA-1007 PET/CT. As such, the latter parameter may assist the interpreting molecular imaging specialist in assigning the correct PSMA-RADS score to sites of disease, thereby increasing diagnostic certainty. In addition, changes of the MIT in PSMA-RADS-5 lesions had no significant impact on SUVmean and TL-PSMA in contrast to PSMA-TV.

Published
2022

43. Hepatic Steatosis and Fibrosis in Chronic Inflammatory Bowel Disease

Author

Claudia Veltkamp, Shuai Lan, Eleni Korompoki, Karl-Heinz Weiss, Hartmut Schmidt, and Helmut K. Seitz

Subjects
Medizin, General Medicine, hepatic steatosis, hepatic fibrosis, Crohn´s disease, ulcerative colitis, elastography, digestive system diseases
Abstract

Background and Purpose: Chronic inflammatory bowel diseases (IBD) frequently affect extraintestinal organs including the liver. Since limited evidence suggests the presence of liver disease in IBD patients, we studied the frequency of hepatic steatosis and fibrosis in these patients and characterized disease-related factors. Methods: In this retrospective, cross-sectional, hospital-based, single-center study, consecutive patients with Crohn’s disease (CD) and ulcerative colitis (UC) were included who had undergone routine abdominal ultrasound including transhepatic elastography. Hepatic steatosis was diagnosed by hyperechogenicity on B-mode ultrasound and by measuring controlled attenuation parameter (CAP). Hepatic fibrosis was assumed if transhepatic elastography yielded a stiffness > 7 kPa. Results: 132 patients (60% CD) with a median disease duration of 10 years were included. Steatosis assessed by B-mode ultrasound and CAP correlated well. Of the IBD patients, 30.3% had non-alcoholic fatty liver (NAFL). Factors associated with NAFL were age, BMI, duration of disease, as well as serum activities of aspartate-aminotransferase (AST) and gamma-glutamyl-transpeptidase (GGT). In multivariate analysis, only disease duration was independently associated with hepatic steatosis. Hepatic fibrosis was found in 10 (8%) of all IBD patients, predominantly in patients with CD (10/11). Conclusions: Pure hepatic steatosis is common in both CD and UC, whereas hepatic fibrosis occurs predominantly in CD patients. Association of disease duration with NAFLD suggests a contribution of IBD-related pathogenetic factors. Longitudinal studies are needed to better understand the impact of IBD on hepatic disorders.

Published
2022

44. Book review

Author

David K. Seitz

Subjects
Social Psychology, Experimental and Cognitive Psychology
Published
2023
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45. A genetic risk score and diabetes predict development of alcohol-related cirrhosis in drinkers

Author

Munir Pirmohamed, Guruprasad P. Aithal, Felix Stickel, Mark Thursz, David Goldman, Paul S. Haber, John Whitfield, Romain Moirand, Bertrand Nalpas, Devanshi Seth, Christophe Moreno, Andrew Thompson, Eric Trepo, Stephen R. Atkinson, Rebecca Darlay, Beat Müllhaupt, Timothy R. Morgan, Dermot Gleeson, Sylvie Naveau, Ann K. Daly, Helmut K. Seitz, Michael Soyka, Christopher P. Day, Tatiana Foroud, Jean-Marc Jacquet, Laura E. Nagy, Naga Chalasani, Pascal Perney, Philippe Mathurin, Marsha Y. Morgan, Pierre Nahon, Sebastian Mueller, Tiebing Liang, Florian Eyer, Suthat Liangpunsakul, Heather J. Cordell, Steven Masson, Tae-Hwi Schwantes-An, Ramon Bataller, Greg Botwin, Andrew McQuillin, QIMR Berghofer Medical Research Institute, Indiana University School of Medicine, Indiana University System, Newcastle University [Newcastle], University of Nottingham, UK (UON), Imperial College London, University of Pittsburgh Medical Center [Pittsburgh, PA, États-Unis] (UPMC), California State University [Long Beach] (CSULB ), Indiana University - Purdue University Indianapolis (IUPUI), Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health [Bethesda] (NIH), The University of Sydney, Hôpital Universitaire Carémeau [Nîmes] (CHU Nîmes), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Hôpital Claude Huriez [Lille], CHU Lille, Nutrition, Métabolismes et Cancer (NuMeCan), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University College of London [London] (UCL), Université libre de Bruxelles (ULB), University of Heidelberg, Medical Faculty, University hospital of Zurich [Zurich], Lerner Research Institute, Cleveland Clinic, Génomique Fonctionnelle des Tumeurs Solides (U1162), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), AP-HP - Hôpital Antoine Béclère [Clamart], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, University of Liverpool, University-Hospital Munich-Großhadern [München], University of California, Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Lerner Research Institute [Cleveland, OH, USA], University of California (UC), Technical University of Munich (TUM), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)

Subjects
Liver Cirrhosis, Male, Cirrhosis, Hepatocellular carcinoma, [SDV]Life Sciences [q-bio], Alcohol, Disease, risk stratification, Gastroenterology, Oral and gastrointestinal, Cohort Studies, Liver disease, Alcohol Use and Health, Substance Misuse, chemistry.chemical_compound, 0302 clinical medicine, Liver Cirrhosis, Alcoholic, single nucleotide polymorphism, Cancer, 2. Zero hunger, 0303 health sciences, Framingham Risk Score, genome wide association, Liver Disease, Single Nucleotide, Middle Aged, Alcoholic, 3. Good health, Alcoholism, Public Health and Health Services, 030211 gastroenterology & hepatology, Female, Risk assessment, Liver Cancer, Adult, medicine.medical_specialty, Alcohol Drinking, Chronic Liver Disease and Cirrhosis, Clinical Sciences, coffee, Polymorphism, Single Nucleotide, Risk Assessment, Article, 03 medical and health sciences, GenomALC Consortium, Rare Diseases, Clinical Research, Diabetes mellitus, Internal medicine, Genetics, Diabetes Mellitus, medicine, Humans, Genetic Predisposition to Disease, Genetic Testing, Polymorphism, Metabolic and endocrine, 030304 developmental biology, Gastroenterology & Hepatology, Hepatology, business.industry, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, Odds ratio, medicine.disease, chronic alcohol use, Good Health and Well Being, chemistry, Case-Control Studies, genome-wide association, Digestive Diseases, business, Body mass index, Genome-Wide Association Study
Abstract

International audience; BACKGROUND and AIMS: Only a minority of excess alcohol drinkers develop cirrhosis. We developed and evaluated risk stratification scores to identify those at highest risk. METHODS: Three cohorts (GenomALC-1: n=1690, GenomALC-2: n=3037, UK Biobank: relevant n=6898) with a history of heavy alcohol consumption (≥80 g/day (men), ≥50 g/day (women), for ≥10 years) were included. Cases were participants with alcohol-related cirrhosis. Controls had a history of similar alcohol consumption but no evidence of liver disease. Risk scores were computed from up to eight genetic loci identified previously as associated with alcohol-related cirrhosis and three clinical risk factors. Score performance for the stratification of alcohol-related cirrhosis risk was assessed and compared across the alcohol-related liver disease spectrum, including hepatocellular carcinoma (HCC). RESULTS: A combination of three single nucleotide polymorphisms (SNPs) (PNPLA3:rs738409, SUGP1-TM6SF2:rs10401969, HSD17B13:rs6834314) and diabetes status best discriminated for cirrhosis risk. The odds ratio (OR) and 95% confidence intervals (CI) for the extreme score quintiles (Q1-Q5) of the 3-SNP score, based on independent allelic effect size estimates, were 5.99 (4.18;8.60) (GenomALC-1); 2.81 (2.03;3.89) (GenomALC-2); and 3.10 (2.32;4.14) (UK Biobank). Patients with diabetes and high-risk score, compared to those without diabetes and a low-risk score, had ORs increased to 14.7 (7.69;28.1) (GenomALC-1) and 17.1 (11.3;25.7) (UK Biobank). Patients with cirrhosis and HCC had significantly higher mean risk scores than patients with cirrhosis alone (0.76±0.06 versus 0.61±0.02, p=0.007). Score performance was not significantly enhanced by information on additional genetic risk variants, body mass index or coffee consumption. CONCLUSIONS: A risk score based on three genetic risk variants and diabetes status can provide meaningful risk stratification for cirrhosis in excess drinkers, allowing earlier prevention planning including intensive intervention. LAY SUMMARY: Excessive chronic drinking leads to liver cirrhosis in some people, but so far there is no way to identify those at high risk of developing this debilitating disease. Our study has developed a genetic risk score (GRS) test that can identify patients at high risk and shows that the risk of cirrhosis is increased >10-fold with just two risk factors - diabetes and high GRS. Risk assessment using this test has potential for early and personalised management of this disease in high-risk patients.

Published
2021
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47. Corrigendum to: ‘A genetic risk score and diabetes predict development of alcohol-related cirrhosis in drinkers’ [J Hepatol 2022 (76) 275–282]

Author

John B. Whitfield, Tae-Hwi Schwantes-An, Rebecca Darlay, Guruprasad P. Aithal, Stephen R. Atkinson, Ramon Bataller, Greg Botwin, Naga P. Chalasani, Heather J. Cordell, Ann K. Daly, Christopher P. Day, Florian Eyer, Tatiana Foroud, Dermot Gleeson, David Goldman, Paul S. Haber, Jean-Marc Jacquet, Tiebing Liang, Suthat Liangpunsakul, Steven Masson, Philippe Mathurin, Romain Moirand, Andrew McQuillin, Christophe Moreno, Marsha Y. Morgan, Sebastian Mueller, Beat Müllhaupt, Laura E. Nagy, Pierre Nahon, Bertrand Nalpas, Sylvie Naveau, Pascal Perney, Munir Pirmohamed, Helmut K. Seitz, Michael Soyka, Felix Stickel, Andrew Thompson, Mark R. Thursz, Eric Trépo, Timothy R. Morgan, and Devanshi Seth

Subjects
Hepatology
Published
2022
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48. ‘Make this adult mess make sense again’: the psychic lives of gentrification’s children

Author

David K. Seitz

Subjects
Cultural Studies, media_common.quotation_subject, 05 social sciences, Geography, Planning and Development, 0211 other engineering and technologies, 0507 social and economic geography, 021107 urban & regional planning, 02 engineering and technology, Gentrification, Psychic, Aesthetics, Children's geographies, Agency (sociology), Queer, Curiosity, Sociology, 050703 geography, media_common
Abstract

This paper advocates for increased scholarly curiosity about the painful and hopeful psychic agency of children and youth in critiquing neoliberal urban gentrification and imagining alterna...

Published
2019
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49. Molekulares Tumorboard Prostatakarzinom

Author

Matthias Heck, M. W. Kamer, Carsten Grüllich, and A. K. Seitz

Subjects
0301 basic medicine, Gynecology, medicine.medical_specialty, business.industry, Urology, medicine.medical_treatment, medicine.disease, Targeted therapy, 03 medical and health sciences, Prostate cancer, 030104 developmental biology, 0302 clinical medicine, 030220 oncology & carcinogenesis, medicine, Tumor board, Hormone replacement therapy, business
Abstract

In der modernen Onkologie ist das molekulare Tumorboard die Schnittstelle zwischen Klinik und Grundlagenforschung. Durch die interdisziplinare Zusammenarbeit von Experten verschiedener Fachdisziplinen soll die Indikation zur molekularbiologischen Tumoranalysen sinnvoll gestellt, die Untersuchungsergebnisse korrekt interpretiert und hierauf basierende personalisierte Therapieempfehlungen ausgegeben werden. Bezogen auf das metastasierte Prostatakarzinom konnen hiervon insbesondere Patienten mit familiarem Prostatakarzinom, jungen Manifestationsalter oder nach Ausschopfung von zugelassenen Standardtherapien profitieren. Mit der Androgenrezeptor-Splicevariante 7 (AR-V7) steht ein pradiktiver Marker fur das Ansprechen auf eine Hormontherapie mit Abirateron oder Enzalutamid zur Verfugung. Testverfahren zur Bestimmung des AR-V7-Status im Blut sind bereits kommerziell erwerblich. Mutationen in den DNA-Reparaturmechanismen stellen einen weiteren Ansatzpunkt fur zielgerichtete, personalisierte Therapien dar. Defekte in der homologen Rekombination erhohen die Empfindlichkeit von Tumorzellen gegenuber Poly(ADP-Ribose)-Polymerase-(PARP-)Inhibitoren wie Olaparib. In der TOPARP-A-Studie, eine Phase-II-Studie, lag die Ansprechrate bei Patienten mit metastasiertem Prostatakarzinom und Mutationen in DNA-Reparaturgenen bei 88 %. Mikrosatelliteninstabilitat ist die Folge von Defekten in der DNA-Mismatch-Reparatur. Mit dem Immun-Checkpoint-Inhibitor Pembrolizumab steht auch fur diese Patientenkollektiv eine wirksame Therapie zur Verfugung. Da weder PARP-Inhibitoren noch Pembrolizumab aktuell zur Therapie des metastasierten Prostatakarzinoms in Deutschland zugelassen sind, starkt die Empfehlung eines molekularen Tumorboards die Erfolgsaussichten fur die Genehmigung eines individuellen Heilversuches durch die Krankenkassen.

Published
2019
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50. 'What do gay Asian men want?': Desiring otherwise in the work of Richard Fung

Author

David K. Seitz

Subjects
030505 public health, Social Psychology, media_common.quotation_subject, 05 social sciences, 0507 social and economic geography, Agency (philosophy), Experimental and Cognitive Psychology, Gender studies, Context (language use), Cultural geography, Racism, 03 medical and health sciences, Politics, Negotiation, Queer, Sociology, 0305 other medical science, 050703 geography, Sophistication, media_common
Abstract

A vast literature on queer of color critique, and increasingly on queer of color geographies, has shed greater light on how queer people of color negotiate racialized sexual economies. This paper considers how cultural geography, informed by psychoanalysis and queer of color critique, might contribute additional sophistication and critical insight to conversations about sexual racism – by not only decrying sexual racism, but by shedding light on racialized people's complex forms of psychical agency, as well as political agency, in relation to it. It turns to the work of gay Trinidadian-Canadian artist and scholar Richard Fung, whose films and essays both proffer underrepresented images of racialized queer sexual subjectivities and grapple with the ways in which queer people of color can themselves become enlisted in racial-sexual hierarchies. Providing geographical and historical context for Toronto's stratified racial and sexual politics as they play out in ordinary life, I point to moments in which Fung's films both decry such inequality and meditate on alternatives that detour from dramas of mis/recognition by whiteness.

Published
2019
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