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1. Measurement of nuclear interaction cross sections towards neutron-skin thickness determination

Author

L. Ponnath, T. Aumann, C.A. Bertulani, R. Gernhäuser, M. Heil, T. Almusidi, H. Alvarez-Pol, L. Atar, L. Atkins, Y. Ayyad, J. Benlliure, K. Boretzky, M.J.G. Borge, L.T. Bott, G. Bruni, B. Brückner, P. Cabanelas, C. Caesar, E. Casarejos, J. Cederkall, A. Corsi, D. Cortina-Gil, J.A. Dueñas, M. Duer, Z. Elekes, S. Escribano Rodriguez, L. Fabbietti, A. Falduto, M. Feijoo, M. Feijoo Fontan, L.M. Fonseca, A. Frotscher, D. Galaviz, E. Galiana, G. García-Jiménez, I. Gašparic̀, E.I. Geraci, A. Gillibert, B. Gnoffo, D. González Caamaño, A. Graña González, K. Göbel, A.-L. Hartig, A. Heinz, T. Hensel, M. Holl, A. Horvat, A. Jedele, D. Jelavic̀ Malenica, T. Jenegger, H.T. Johansson, B. Jonson, N. Kalantar-Nayestanaki, A. Kelic-Heil, O.A. Kiselev, P. Klenze, D. Kresan, T. Kröll, E. Kudaibergenova, D. Kurtulgil, D. Körper, M. Labiche, C. Langer, I. Lihtar, Yu.A. Litvinov, B. Löher, J. Mayer, S. Murillo Morales, E. Nacher, T. Nilsson, A. Obertelli, V. Panin, J. Park, S. Paschalis, A. Perea, M. Petri, S. Pirrone, T. Pohl, R. Reifarth, H.-B. Rhee, J.L. Rodriguez-Sanchez, L. Rose, D.M. Rossi, P. Russotto, D. Savran, H. Scheit, H. Simon, S. Storck-Dutine, A.M. Stott, C. Sürder, R. Taniuchi, O. Tengblad, P. Teubig, L. Trache, M. Trimarchi, H.T. Törnqvist, L. Varga, V. Wagner, and F. Wamers

Subjects
Physics, QC1-999
Abstract

The accuracy of reaction theories used to extract properties of exotic nuclei from scattering experiments is often unknown or not quantified, but of utmost importance when, e.g., constraining the equation of state of asymmetric nuclear matter from observables as the neutron-skin thickness. In order to test the Glauber multiple-scattering model, the total interaction cross section of Image 1 on carbon targets was measured at initial beam energies of 400, 550, 650, 800, and 1000 MeV/nucleon. The measurements were performed during the first experiment of the newly constructed R3B (Reaction with Relativistic Radioactive Beams) experiment after the start of FAIR Phase-0 at the GSI/FAIR facility with beam energies of 400, 550, 650, 800, and 1000 MeV/nucleon. The combination of the large-acceptance dipole magnet GLAD and a newly designed and highly efficient Time-of-Flight detector enabled a precise transmission measurement with several target thicknesses for each initial beam energy with an experimental uncertainty of ±0.4%. A comparison with the Glauber model revealed a discrepancy of around 3.1% at higher beam energies, which will serve as a crucial baseline for the model-dependent uncertainty in future fragmentation experiments.

Published
2024
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2. Precise measurement of nuclear interaction cross sections towards neutron-skin determination with R3B

Author

Ponnath, L., Aumann, T., Bertulani, C.A., Gernhäuser, R., Almusidi, T., Alvarez-Pol, H., Atar, L., Atkins, L., Ayyad, Y., Benlliure, J., Boretzky, K., Borge, M.J.G., Bott, L.T., Bruni, G., Brückner, B., Cabanelas, P., Caesar, C., Casarejos, E., Cederkall, J., Corsi, A., Cortina-Gil, D., Dueñas, J.A., Duer, M., Elekes, Z., Escribano Rodriguez, S., Falduto, A., Feijoo, M., Feijoo Fontan, M., Fonseca, L.M., Frotscher, A., Galaviz, D., Galiana, E., García-Jiménez, G., Gašparić, I., Geraci, E.I., Gillibert, A., Gnoffo, B., González Caamaño, D., Graña González, A., Göbel, K., Hartig, A.-L., Heil, M., Heinz, A., Hensel, T., Holl, M., Horvat, A., Jedele, A., Jelavić Malenica, D., Jenegger, T., Johansson, H.T., Jonson, B., Kalantar-Nayestanaki, N., Kelic-Heil, A., Kiselev, O.A., Klenze, P., Kresan, D., Kröll, T., Kudaibergenova, E., Kurtulgil, D., Körper, D., Labiche, M., Langer, C., Lihtar, I., Litvinov, Yu.A., Löher, B., Mayer, J., Mozumdar, N., Murillo Morales, S., Nacher, E., Nilsson, T., Obertelli, A., Panin, V., Park, J., Paschalis, S., Perea, A., Petri, M., Pirrone, S., Pohl, T., Reifarth, R., Rhee, H.-B., Rodriguez-Sanchez, J.L., Rose, L., Rossi, D.M., Russotto, P., Savran, D., Scheit, H., Simon, H., Storck-Dutine, S., Stott, A.M., Sun, Y., Sürder, C., Taniuchi, R., Tengblad, O., Teubig, P., Trache, L., Trimarchi, M., Törnqvist, H.T., Wagner, V., and Wamers, F.

Published
2025
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3. Where Is My Training Bottleneck? Hidden Trade-Offs in Deep Learning Preprocessing Pipelines

Author

Isenko, Alexander, Mayer, Ruben, Jedele, Jeffrey, and Jacobsen, Hans-Arno

Subjects
Computer Science - Machine Learning, Computer Science - Distributed, Parallel, and Cluster Computing, Computer Science - Performance, I.4.0, I.4.2, I.2.0, B.4.4, C.4, D.2.8
Abstract

Preprocessing pipelines in deep learning aim to provide sufficient data throughput to keep the training processes busy. Maximizing resource utilization is becoming more challenging as the throughput of training processes increases with hardware innovations (e.g., faster GPUs, TPUs, and inter-connects) and advanced parallelization techniques that yield better scalability. At the same time, the amount of training data needed in order to train increasingly complex models is growing. As a consequence of this development, data preprocessing and provisioning are becoming a severe bottleneck in end-to-end deep learning pipelines. In this paper, we provide an in-depth analysis of data preprocessing pipelines from four different machine learning domains. We introduce a new perspective on efficiently preparing datasets for end-to-end deep learning pipelines and extract individual trade-offs to optimize throughput, preprocessing time, and storage consumption. Additionally, we provide an open-source profiling library that can automatically decide on a suitable preprocessing strategy to maximize throughput. By applying our generated insights to real-world use-cases, we obtain an increased throughput of 3x to 13x compared to an untuned system while keeping the pipeline functionally identical. These findings show the enormous potential of data pipeline tuning., Comment: To be published in SIGMOD, June 12-17, 2022, Philadelphia, PA, USA. Repository: https://github.com/cirquit/presto

Published
2022
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6. Measurement of Nuclear Interaction Cross Sections towards Neutron-Skin Thickness Determination

Author

Ponnath, L., primary, Aumann, T., additional, Bertulani, C.A., additional, Gernhäuser, R., additional, Heil, M., additional, Almusidi, T., additional, Alvarez-Pol, H., additional, Atar, L., additional, Atkins, L., additional, Ayyad, Y., additional, Benlliure, J., additional, Boretzky, K., additional, Borge, M.J.G., additional, Bott, L.T., additional, Bruni, G., additional, Brückner, B., additional, Cabanelas, P., additional, Caesar, C., additional, Casarejos, E., additional, Cederkall, J., additional, Corsi, A., additional, Cortina-Gil, D., additional, Dueñas, J.A., additional, Duer, M., additional, Elekes, Z., additional, Escribano Rodriguez, S., additional, Fabbietti, L., additional, Falduto, A., additional, Feijoo, M., additional, Feijoo Fontan, M., additional, Fonseca, L.M., additional, Frotscher, A., additional, Galaviz, D., additional, Galiana, E., additional, García-Jiménez, G., additional, Gašparic̀, I., additional, Geraci, E.I., additional, Gillibert, A., additional, Gnoffo, B., additional, González Caamaño, D., additional, Graña González, A., additional, Göbel, K., additional, Hartig, A.-L., additional, Heinz, A., additional, Hensel, T., additional, Holl, M., additional, Horvat, A., additional, Jedele, A., additional, Jelavic̀ Malenica, D., additional, Jenegger, T., additional, Johansson, H.T., additional, Jonson, B., additional, Kalantar-Nayestanaki, N., additional, Kelic-Heil, A., additional, Kiselev, O.A., additional, Klenze, P., additional, Kresan, D., additional, Kröll, T., additional, Kudaibergenova, E., additional, Kurtulgil, D., additional, Körper, D., additional, Labiche, M., additional, Langer, C., additional, Lihtar, I., additional, Litvinov, Yu.A., additional, Löher, B., additional, Mayer, J., additional, Murillo Morales, S., additional, Nacher, E., additional, Nilsson, T., additional, Obertelli, A., additional, Panin, V., additional, Park, J., additional, Paschalis, S., additional, Perea, A., additional, Petri, M., additional, Pirrone, S., additional, Pohl, T., additional, Reifarth, R., additional, Rhee, H.-B., additional, Rodriguez-Sanchez, J.L., additional, Rose, L., additional, Rossi, D.M., additional, Russotto, P., additional, Savran, D., additional, Scheit, H., additional, Simon, H., additional, Storck-Dutine, S., additional, Stott, A.M., additional, Sürder, C., additional, Taniuchi, R., additional, Tengblad, O., additional, Teubig, P., additional, Trache, L., additional, Trimarchi, M., additional, Törnqvist, H.T., additional, Varga, L., additional, Wagner, V., additional, and Wamers, F., additional

Published
2024
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10. New KCNN4 Variants Associated With Anemia: Stomatocytosis Without Erythrocyte Dehydration

Author

B. Allegrini, S. Jedele, L. David Nguyen, M. Mignotet, R. Rapetti-Mauss, C. Etchebest, O. Fenneteau, A. Loubat, A. Boutet, C. Thomas, J. Durin, A. Petit, C. Badens, L. Garçon, L. Da Costa, and H. Guizouarn

Subjects
Hereditary Xerocytosis, Stomatocytosis, red blood cell, Gardos, KCNN4, Physiology, QP1-981
Abstract

The K+ channel activated by the Ca2+, KCNN4, has been shown to contribute to red blood cell dehydration in the rare hereditary hemolytic anemia, the dehydrated hereditary stomatocytosis. We report two de novo mutations on KCNN4, We reported two de novo mutations on KCNN4, V222L and H340N, characterized at the molecular, cellular and clinical levels. Whereas both mutations were shown to increase the calcium sensitivity of the K+ channel, leading to channel opening for lower calcium concentrations compared to WT KCNN4 channel, there was no obvious red blood cell dehydration in patients carrying one or the other mutation. The clinical phenotype was greatly different between carriers of the mutated gene ranging from severe anemia for one patient to a single episode of anemia for the other patient or no documented sign of anemia for the parents who also carried the mutation. These data compared to already published KCNN4 mutations question the role of KCNN4 gain-of-function mutations in hydration status and viability of red blood cells in bloodstream.

Published
2022
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11. Design and Testing of a new Tracking System for the Proton Charge Radius Measurement with the AMBER Experiment at CERN

Author

Alexeev, Maxim, primary, Alice, Chiara, additional, Amoroso, Antonio, additional, Bajzek, Martin, additional, Chiosso, Michela, additional, Denisov, Oleg, additional, Dreisbach, Christian, additional, Eichhorn, Karl, additional, Fischer, Horst, additional, Friedrich, Jan, additional, Argos, Carlos García, additional, Giordano, Davide, additional, Hoffmann, Martin, additional, Jedele, Andrea, additional, Kiselev, Oleg, additional, Klenze, Philipp, additional, Konorov, Igor, additional, Löher, Bastian, additional, Losekamm, Martin J., additional, Panzieri, Daniele, additional, Paul, Stephan, additional, Pires, Christophe, additional, Pöschl, Thomas, additional, Rodríguez-Sánchez, Jose Luis, additional, Rose, Luke, additional, Schmidt, Christian Joachim, additional, Seitz, Bjoern, additional, Sosio, Stefano, additional, Thomson, Francis, additional, Tornqvist, Hans, additional, Veit, Benjamin Moritz, additional, and Visinka, Robert, additional

Published
2024
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13. Coulomb dissociation of 16O into 4He and 12C

Author

Bott Lukas Thomas, Göbel Kathrin, Heil Michael, Kelić-Heil Aleksandra, Reifarth René, Aliotta Marialuisa, Almusidi Tahani, Alvarez-Pol Hector, Atar Leyla, Atkins Liam, Aumann Thomas, Bemmerer Daniel, Benlliure José, Bertulani Carlos, Boretzky Konstanze, Brückner Benjamin, Brandenburg Leonhard, Bruni Giovanni, Cabanelas Eiras Pablo, Caesar Christoph, Casarejos Enrique, Cederkall Joakim, Chulkov Leonid, Cortina-Gil Dolores, Danilov Andrey, De Filippo Enrico, Dellmann Sophia Florence, Deuter Isabell, Dueñas Díaz José Antonio, Duer Meytal, Elekes Zoltan, Erbacher Philipp, Escribano Rodriguez Sonia, Fülöp Zsolt, Falduto Ashton, Feijoo Manuel, Fiebiger Stefan, Gašparić Igor, Galaviz Daniel, García Borge María José, García-Jiménez Gabriel, Geraci Elena, Gernhäuser Roman, Glorius Jan, Gnoffo Brunilde, González Caamaño David, Graña González Antia, Grein Alexander, Hartig AnnaLena, Heftrich Tanja, Heggen Henning, Heine Marcel, Heinz Andreas, Henrich Corinna, Hensel Thomas, Holl Matthias, Homm Ilja, Horváth Ákos, Horvat Andrea, Jedele Andrea, Jelavic Malenica Desa, Jenegger Tobias, Johansson Håkan T., Jonson Björn, Kahlbow Julian, Kalantar-Nayestanaki Nasser, Kamenyero Armel, Khasawneh Kafa, Kiselev Oleg, Klenze Philipp, Knösel Marco, Koch Karsten, Kohls Marvin, Körper Daniel, Kröll Thorsten, Krasilovskaja Sabina, Kresan Dmytro, Kurtulgil Deniz, Kurz Nikolaus, Löher Bastian, Langer Christoph, Lederer-Woods Claudia, Lehr Christopher, Litvinov Yuri A, Lorenz Enis, Martorana Nunzia Simona, Motobayashi Tohru, Murillo Morales Silvia, Nacher Enrique, Nilsson Thomas, Pagano Emanuele Vincenzo, Panin Valerii, Park Joochun, Paschalis Stefanos, Perea Angel, Petri Marina, Pirrone Sara, Plag Ralf, Ponnath Lukas, Popočovski Romana, Reich Markus, Rhee Han-Bum, Rodriguez Sanchez Jose Luis, Rossi Dominic, Russotto Paolo, Sánchez-Benítez Ángel-Miguel, Sürder Christian, Savran Deniz, Scheit Heiko, Schmidt Konrad, Schulte Hendrik, Simon Haik, Simon Johannes, Starostin Viktor, Storck-Dutine Sonja, Törnqvist Hans Toshihide, Tanaka Junki, Tengblad Olof, Thomas Benedikt, Trimarchi Marina, Typel Stefan, Varga László, Volk Klaus, Volknandt Meiko, Wagner Vadim, Wamers Felix, Weigand Mario, and Zanetti Lorenzo

Subjects
Physics, QC1-999
Abstract

We measured the Coulomb dissociation of 16O into 4He and 12C within the FAIR Phase-0 program at GSI Helmholtzzentrum für Schwerionenforschung Darmstadt, Germany. From this we will extract the photon dissociation cross section 16O(α,γ)12C, which is the time reversed reaction to 12C(α,γ)16O. With this indirect method, we aim to improve on the accuracy of the experimental data at lower energies than measured so far. The expected low cross section for the Coulomb dissociation reaction and close magnetic rigidity of beam and fragments demand a high precision measurement. Hence, new detector systems were built and radical changes to the R3B setup were necessary to cope with the high-intensity 16O beam. All tracking detectors were designed to let the unreacted 16O ions pass, while detecting the 12C and 4He.

Published
2023
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14. Measurements of the Reaction Cross Sections of Neutron-rich Sn Isotopes at the R\(^3\)B Setup

Author

Kudaibergenova, E., primary, Lihtar, I., additional, Feijoo-Fontán, M., additional, Aumann, T., additional, Bertulani, C.A., additional, Gašparić, I., additional, Horvat, A., additional, Panin, V., additional, Rodríguez-Sánchez, J.L., additional, Rossi, D., additional, Storck-Dutine, S., additional, Törnqvist, H.T., additional, Alvarez-Pol, H., additional, Atar, L., additional, Benlliure, J., additional, Boretzky, K., additional, Bott, L.T., additional, Caesar, C., additional, Casarejos, E., additional, Cederkall, J., additional, Chatillon, A., additional, Cortina-Gil, D., additional, de Filippo, E., additional, Dickel, T., additional, Duer, M., additional, Falduto, A., additional, Fonseca, L.M., additional, Galaviz, D., additional, García-Jiménez, G., additional, Ge, Z., additional, Geraci, E.I., additional, Gernhüser, R., additional, Gnoffo, B., additional, Graña-González, A., additional, Göbel, K., additional, Hartig, A.L., additional, Heil, M., additional, Heinz, A., additional, Hensel, T., additional, Holl, M., additional, Jedele, A., additional, Jelavic-Malenica, D., additional, Jenegger, T., additional, Ji, L., additional, Johansson, H.T., additional, Jonson, B., additional, Kalantar-Nayestanaki, N., additional, Kelić-Heil, A., additional, Kiselev, O.A., additional, Klenze, P., additional, Körper, D., additional, Kröll, T., additional, Litvinov, Yu.A., additional, Löher, B., additional, Martorana, N.S., additional, Morfouace, P., additional, Murillo-Morales, S., additional, Nociforo, C., additional, Obertelli, A., additional, Paschalis, S., additional, Perea, A., additional, Petri, M., additional, Pietri, S., additional, Pirrone, S., additional, Ponnath, L., additional, Rhee, H.B., additional, Rose, L., additional, Russotto, P., additional, Savran, D., additional, Scheit, H., additional, Simon, H., additional, Simon, J.P., additional, Stott, A.M., additional, Sun, Y., additional, Symochko, D., additional, Sürder, C., additional, Taieb, J., additional, Taniuchi, R., additional, Tengblad, O., additional, Velardita, S., additional, and Wamers, F., additional

Published
2024
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19. Implementation Lessons Learned: Distress Behaviors in Dementia Intervention in Veterans Health Administration.

Author

Curyto, Kim, Wray, Laura O, Sullivan, Jennifer L, McConnell, Eleanor S, Jedele, Jenefer M, Minor, Lisa, and Karel, Michele J

Subjects
TREATMENT of dementia, CONFIDENCE, RESEARCH methodology, SELF-perception, SURVEYS, CONCEPTUAL structures, HUMAN services programs, INDEPENDENT living, HEALTH care teams, DESCRIPTIVE statistics, RESEARCH funding, CONTENT analysis, MEDICAL care of veterans, PSYCHOLOGICAL distress
Abstract

Background and Objectives Evidence-based practices to manage distress behaviors in dementia (DBD) are not consistently implemented despite demonstrated effectiveness. The Veterans Health Administration (VA) trained teams to implement Staff Training in Assisted Living Residences (STAR)-VA, an intervention to manage DBD in VA nursing home settings, or Community Living Centers (CLCs). This paper summarizes multiyear formative evaluation results including challenges, adaptations, and lessons learned to support sustained integration into usual care across CLCs nationwide. Research Design and Methods STAR was selected as an evidence-based practice for DBD, adapted for and piloted in VA (STAR-VA), and implemented through a train-the-trainer program from 2013 to 2018. Training and consultation were provided to 92 CLC teams. Evaluation before and after training and consultation included descriptive statistics of measures of clinical impact and survey feedback from site teams regarding self-confidence, engagement, resource quality, and content analysis of implementation facilitators and challenges. Results STAR-VA training and consultation increased staff confidence and resulted in significant decreases in DBD, depression, anxiety, and agitation for Veterans engaged in the intervention. Implementation outcomes demonstrated feasibility and identified facilitators and barriers. Key findings were interpreted using implementation frameworks and informed subsequent modifications to sustain implementation. Discussion and Implications STAR-VA successfully prepared teams to manage DBD and resulted in improved outcomes. Lessons learned include importance of behavioral health–nursing partnerships, continuous engagement, iterative feedback and adaptations, and sustainment planning. Evaluation of sustainment factors has informed selection of implementation strategies to address sustainment barriers. Lessons learned have implications for integrating team-based practices into system-level practice. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Coulomb dissociation of $^{16}O$ into $^{4}He$ and $^{12}C$

Author

Bott, Lukas Thomas, Göbel, Kathrin, Heil, Michael, Kelić-Heil, Aleksandra, Reifarth, René, Aliotta, Marialuisa, Almusidi, Tahani, Alvarez-Pol, Hector, Atar, Leyla, Atkins, Liam, Aumann, Thomas, Bemmerer, Daniel, Benlliure, José, Bertulani, Carlos, Boretzky, Konstanze, Brückner, Benjamin, Brandenburg, Leonhard, Bruni, Giovanni, Cabanelas Eiras, Pablo, Caesar, Christoph, Casarejos, Enrique, Cederkall, Joakim, Chulkov, Leonid, Cortina-Gil, Dolores, Danilov, Andrey, De Filippo, Enrico, Dellmann, Sophia Florence, Deuter, Isabell, Dueñas Díaz, José Antonio, Duer, Meytal, Elekes, Zoltan, Erbacher, Philipp, Escribano Rodriguez, Sonia, Fülöp, Zsolt, Falduto, Ashton, Feijoo, Manuel, Fiebiger, Stefan, Gašparić, Igor, Galaviz, Daniel, García Borge, María José, García-Jiménez, Gabriel, Geraci, Elena, Gernhäuser, Roman, Glorius, Jan, Gnoffo, Brunilde, González Caamaño, David, Graña González, Antia, Grein, Alexander, Hartig, AnnaLena, Heftrich, Tanja, Heggen, Henning, Heine, Marcel, Heinz, Andreas, Henrich, Corinna, Hensel, Thomas, Holl, Matthias, Homm, Ilja, Horváth, Ákos, Horvat, Andrea, Jedele, Andrea, Jelavic Malenica, Desa, Jenegger, Tobias, Johansson, Håkan T., Jonson, Björn, Kahlbow, Julian, Kalantar-Nayestanaki, Nasser, Kamenyero, Armel, Khasawneh, Kafa, Kiselev, Oleg, Klenze, Philipp, Knösel, Marco, Koch, Karsten, Kohls, Marvin, Körper, Daniel, Kröll, Thorsten, Krasilovskaja, Sabina, Kresan, Dmytro, Kurtulgil, Deniz, Kurz, Nikolaus, Löher, Bastian, Langer, Christoph, Lederer-Woods, Claudia, Lehr, Christopher, Litvinov, Yuri A, Lorenz, Enis, Martorana, Nunzia Simona, Motobayashi, Tohru, Murillo Morales, Silvia, Nacher, Enrique, Nilsson, Thomas, Pagano, Emanuele Vincenzo, Panin, Valerii, Park, Joochun, Paschalis, Stefanos, Perea, Angel, Petri, Marina, Pirrone, Sara, Plag, Ralf, Ponnath, Lukas, Popočovski, Romana, Reich, Markus, Rhee, Han-Bum, Rodriguez Sanchez, Jose Luis, Rossi, Dominic, Russotto, Paolo, Sánchez-Benítez, Ángel-Miguel, Sürder, Christian, Savran, Deniz, Scheit, Heiko, Schmidt, Konrad, Schulte, Hendrik, Simon, Haik, Simon, Johannes, Starostin, Viktor, Storck-Dutine, Sonja, Törnqvist, Hans Toshihide, Tanaka, Junki, Tengblad, Olof, Thomas, Benedikt, Trimarchi, Marina, Typel, Stefan, Varga, László, Volk, Klaus, Volknandt, Meiko, Wagner, Vadim, Wamers, Felix, Weigand, Mario, and Zanetti, Lorenzo

Abstract

10th Conference on Nuclear Physics in Astrophysics, NPA-X 2022, Geneva, Switzerland, 5 Sep 2022 - 9 Sep 2022; The European physical journal / Web of Conferences 279, 04003 (2023). doi:10.1051/epjconf/202327904003, Published by EDP Sciences, Les Ulis

Published
2023
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25. Apparent temperatures of neutron-poor and neutron-rich compound nuclei

Author

McIntosh, A. B., primary, Hagel, K., additional, McIntosh, L. A., additional, Wada, R., additional, Gauthier, J., additional, Cammarata, P. J., additional, Keeler, A., additional, Abbott, A., additional, Hannaman, A., additional, Harvey, B., additional, Jedele, A., additional, Lui, Y. W., additional, May, L. W., additional, Sorensen, M., additional, Youngs, M., additional, Zarrella, A., additional, and Yennello, S. J., additional

Published
2023
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26. Investigating the time dependence of neutron-proton equilibration using molecular dynamics simulations

Author

Jedele, A., primary, Hagel, K., additional, Sorensen, M. Q., additional, Harvey, B., additional, Abbott, A., additional, Gauthier, J., additional, Hannaman, A., additional, Hood, A. A., additional, Lui, Y.-W., additional, McCann, L., additional, McIntosh, A. B., additional, McIntosh, L. A., additional, Schultz, S., additional, Tobin, Z., additional, Wada, R., additional, Youngs, M., additional, and Yennello, S., additional

Published
2023
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27. A new Time-of-flight detector for the R$$^3$$B setup

Author

Heil, M., Kelić-Heil, A., Bott, L., Almusidi, T., Alvarez-Pol, H., Atar, L., Atkins, L., Aumann, T., Benlliure, J., Boretzky, K., Brückner, B., Cabanelas, P., Caesar, C., Casarejos, E., Cederkall, J., Chulkov, L., Corsi, A., Dueñas, J., Erbacher, P., Rodriguez, S. Escribano, Falduto, A., Feijoo, M., Frotscher, A., Frühauf, J., Gašparić, I., Borge, M. J. G., Gerbig, J., Gernhäuser, R., Gilbert, M., Glorius, J., Gnoffo, B., Göbel, K., Caamaño, D. Gonzalez, Grein, A., Hartig, A.-L., Heggen, H., Heine, M., Heinz, A., Holl, M., Homm, I., Horvat, A., Johansson, H. T., Jonson, B., Kalantar-Nayestanaki, N., Kamenyero, A., Khodaparast, A., Kiselev, O., Klenze, P., Knösel, M., Koch, K., Körper, D., Kröll, T., Kurtulgil, D., Kurz, N., Löher, B., Langer, C., Lehr, C., Litvinov, Y., Liu, H., Morales, S. Murillo, Nácher, E., Nilsson, T., Park, J., Paschalis, S., Pellegri, L., Perea, A., Petri, M., Pohl, T., Ponnath, L., Popočovski, R., Reifarth, R., Rhee, H.-B., Sanchez, J. L. Rodriguez, Rossi, D., Sürder, C., Sánchez-Benítez, A. M., Savran, D., Scheit, H., Simon, H., Slavkovská, Z., Storck-Dutine, S., Sun, Y., Törnqvist, H. T., Tanaka, J., Tengblad, O., Thomas, B., Varga, L., Volknandt, M., Wagner, V., Wamers, F., Zanetti, L., Aliotta, Marialuisa, Alkhazov, Georgy, Almusidi, Tahani, Alvarez-Pol, Hector, André, Paul, Assié, Marlène, Atar, Leyla, Atkins, Liam, Audouin, Laurent, Aumann, Thomas, Authelet, Gilles, Ayyad, Yassid, Bajzek, Martin, Barriere, Antoine, Beceiro-Novo, Saul, Belogurov, Sergey, Bemmerer, Daniel, Benlliure, Jose, Bertulani, Carlos, Bezbakh, Andrey, Blanchon, Guillaume, Boos, Carl Georg, Boretzky, Konstanze, Borge, Maria J., Borzov, Ivan, Bott, Lukas, Brückner, Benjamin, Cabanelas Eiras, Pablo, Caesar, Christoph, Calinescu, Stefana, Casarejos, Enrique, Catford, Wilton, Cederkall, Joakim, Chatillon, Audrey, Cherciu, Madalin Ilie, Chishti, M Majid Rauf, Chulkov, Leonid, Cirstian, Andreea, Corsi, Anna, Cortina-Gil, Dolores, Cravo, Edgar, Crespo, Raquel, Danilov, Andrey, de Angelis, Giacomo, De Filippo, Enrico, Diaz-Torres, Alexis, Dickel, Timo, Dobrovolsky, Alexander, Doornenbal, Pieter, Duer, Meytal, Egelhof, Peter, Elekes, Zoltan, Enders, Joachim, Erbacher, Philipp, Escribano Rodriguez, Sonia, Fahlander, Claes, Falduto, Ashton, Feijoo, Martina, Fernandez Ruiz, Daniel, Fomichev, Andrey, Fulop, Zsolt, Galaviz Redondo, Daniel, Galiana, Elisabet, García, Gabriel, García Távora, Vicente, Gasparic, Igor, Ge, Zhuang, Geissel, Hans, Geraci, Elena, Gerl, Jürgen, Gernhäuser, Roman, Gillibert, Alain, Glorius, Jan, Gnoffo, Brunilde, Göbel, Kathrin, Golovkov, Mikhail, Golovtsov, Victor, Golubev, Pavel, González Caamaño, David, Gorshkov, Alexander, Graña González, Antia, Gridnev, Anatoly, Gruzinskii, Nikolai, Guimaraes, Valdir, Harakeh, Muhsin N., Hartig, Anna-Lena, Heftrich, Tanja, Heggen, Henning, Heil, Michael, Heinz, Andreas, Hen, Or, Henrich, Corinna, Henriques, Ana, Hensel, Thomas, Holl, Matthias, Homm, Ilja, Horvat, Andrea, Horváth, Ákos, Hucka, Jan-Paul, Inglessi, Alexander, Jedele, Andrea, Jelavic Malenica, Desa, Jenegger, Tobias, Ji, Liancheng, Johansson, Håkan, Jonson, Björn, Jurado, Beatriz, Kahlbow, Julian, Kalantar-Nayestanaki, Nasser, Kamenyero, Armel, Kazantseva, Erika, Kelic-Heil, Aleksandra, Khanzadeev, Alexey, Kiselev, Oleg, Klenze, Philipp, Knyazev, Alexander, Koch, Karsten, Kogimtzis, Moschos, Kokubun, Kei, Korolev, Guerman, Körper, Daniel, Korsheninnikov, Alexey, Korten, Wolfram, Kozlenko, Nikolai, Krasilovskaja, Sabina, Kresan, Dmytro, Krivshich, Anatoly, Kröll, Thorsten, Krupko, Sergey, Kudaibergenova, Eleonora, Kunne Sohler, Dorottya, Kurtulgil, Deniz, Kurz, Nikolaus, Kuzmin, Evgeny, Kuznetsov, Viacheslav, Labiche, Marc, Lagni, Andrea, Langer, Christoph, Lányi, Zsombor, Lazarus, Ian, Le Fèvre, Arnaud, Leifels, Yvonne, Lepine-Szily, Alinka, Lewitowicz, Marek, Lihtar, Ivana, Linh, Bui, Litvinov, Yuri, Liu, Hongna, Löher, Bastian, Lommel, Bettina, Lorenz, Enis, Lukasik, Jerzy, Macchiavelli, Augusto, Maev, Evgeny, Maillertet, Charles, Maisuzenko, Dmitrii, Maj, Adam, Martorana, Nunzia Simona, Mauss, Benoît, Mayri, Christophe, Milhomens da Fonseca, Leandro, Morfouace, Pierre, Mozumdar, Nikhil, Mücher, Dennis, Murillo Morales, Silvia, Nacher, Enrique, Nikolskii, Evgenii, Nilsson, Thomas, Nociforo, Chiara, Nolden, Fritz, Nyman, Göran, Obertelli, Alexandre, Pagano, Emanuele Vincenzo, Panin, Valerii, Park, Joochun, Paschalis, Stefanos, Pei, Junchen, Perea, Angel, Petri, Marina, Piasetzky, Eli, Pietri, Stephane, Pirrone, Sara, Politi, Giuseppe, Pollacco, Emauel, Ponnath, Lukas, Potlog, Petru-Mihai, Prajapat, Rinku, Pritula, Roman, Qi, Hang, Rappold, Christophe, Reifarth, Rene, Revel, Aldric, Rhee, Han-Bum, Risitano, Fabio, Rodriguez Sanchez, Jose Luis, Rose, Luke, Rossi, Dominic, Rudigier, Matthias, Russotto, Paolo, Sánchez-Benítez, Ángel-Miguel, Sanjari, Shahab, Santamaria, Clementine, Sarantsev, Victor, Savran, Deniz, Scheidenberger, Christoph, Scheit, Heiko, Schmidt, Konrad, Simon, Haik, Simon, Johannes, Slavkovská, Zuzana, Slepnev, Roman, Sorlin, Olivier, Sousa, Tomás, Spiridon, Alexandra, Stan, Emil, Stanoiu, Mihai, Stefanescu, Alexandra, Stefanescu, Ionut, Storck-Dutine, Sonja, Stott, Aaron, Sun, Baohua, Sun, Yelei, Sürder, Christian, Taieb, Julien, Tanaka, Junki, Tanihata, Isao, Taniuchi, Ryo, Tengblad, Olof, Terekhin, Pavel, Teubig, Pamela, Törnqvist, Hans, Trache, Livius, Trautmann, Wolfgang, Trimarchi, Marina, Typel, Stefan, Uesaka, Tomohiro, Unsworth, Carl, Uvarov, Lev, Vandebrouck, Marine, Varga, Laszlo, Velardita, Simone, Velho, Paulo, Vencelj, Matjaz, Volknandt, Meiko, Volkov, Sergei, von Tresckow, Martin, Wagner, Andreas, Wamers, Felix, Wang, Yanzhao, Whitehead, Matthew, Wienholtz, Frank, Wimmer, Kathrin, Winkler, Martin, Xarepe, Manuel, Ye, Yanlin, Zacarias, Sabrina, Zamora Cardona, Juan Carlos, Zhang, Wei, Zhdanov, Andrei, Zhukov, Mikhail, Zilges, Andreas, Zuber, Kai, Département de Physique Nucléaire (ex SPhN) (DPHN), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Grand Accélérateur National d'Ions Lourds (GANIL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), R3B, Federal Ministry of Education and Research (Germany), Helmholtz International Center for FAIR, Ministerio de Ciencia e Innovación (España), Xunta de Galicia, Agencia Estatal de Investigación (España), Swedish Research Council, Science and Technology Facilities Council (UK), Royal Society (UK), Projekt DEAL, Energy and Sustainability Research Institute Groni, and Nuclear Energy

Subjects
Nuclear and High Energy Physics, ddc:530, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det]
Abstract

19 pags., 16 figs., 8 tabs., We present the design, prototype developments and test results of the new time-of-flight detector (ToFD) which is part of the R3B experimental setup at GSI and FAIR, Darmstadt, Germany. The ToFD detector is able to detect heavy-ion residues of all charges at relativistic energies with a relative energy precision σΔE/ ΔE of up to 1% and a time precision of up to 14 ps (sigma). Together with an elaborate particle-tracking system, the full identification of relativistic ions from hydrogen up to uranium in mass and nuclear charge is possible., This work received support from BMBF (05P19RFFN1, 05P15RDFN1, 05P19RDFN1) and HIC for FAIR. J.P. has been supported by the Institute for Basic Science (IBS-R031-D1). E.C. has been supported by the Ministry of Science and Innovation in Spain (PGC2018-099746-B-C22). J.L.R.S. thanks the support from the Regional Government of Galicia under the program of postdoctoral fellowships ED481B-2017-002 and ED481D-2021-018. O.T. has been supported by AEI/FEDER, UE project No. PID2019-104390GB-I00. G.B., A.H., H.T.J., B.J. and T.N. have been supported by the Swedish Research Council under contract 2017-03839. This work was supported by the Royal Society and UK STFC awards ST/L005727/1, ST/P003885/1.

Published
2022
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29. A Faculty 'C' Change: Inspired by Learning Communities

Author

Jedele, Randall E.

Abstract

Looking back on 27 years of teaching experience, it's tempting to think the biggest changes have been in technology. Certainly, going from carbon copies and mimeograph machines to word processing and teaching on Blackboard in a Web-blended course has been a huge transition. But the most radical transformation in teaching for the author began when he started teaching in learning communities. These teaching experiences were, indeed, a sea change for him because they transformed his pedagogy and how he teaches with colleagues. Because his teaching experiences were so powerful, and because he knew he couldn't be the only one having these experiences, he devoted his doctoral research to trying to determine how others perceived the effects of teaching in learning communities, including how teaching in stand-alone classes might have been altered as well. Ultimately, his dissertation research reinforced what he experienced in his own teaching: Those teachers teaching in learning communities did experience a sea change in their pedagogy. They could see how their participation influenced how they viewed what he calls "C" changes: camaraderie, cooperation, collegiality, collaboration, curriculum integration, creative teaching techniques, and community building, all of which influenced their growth and development as teachers. (Contains 13 endnotes.)

Published
2010

30. New KCNN4 Variants Associated With Anemia: Stomatocytosis Without Erythrocyte Dehydration

Author

Allegrini, B., Jedele, S., Nguyen, L. David, Mignotet, M., Rapetti-Mauss, R., Etchebest, C., Fenneteau, O., Loubat, A., Boutet, A., Thomas, C., Durin, J., Petit, A., Badens, C., Garçon, Loïc, da Costa, Lydie, Guizouarn, H., Institut de Biologie Valrose (IBV), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Biologie Intégrée du Globule Rouge (BIGR (UMR_S_1134 / U1134)), Institut National de la Transfusion Sanguine [Paris] (INTS)-Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Université des Antilles (UA)-Université Paris Cité (UPCité), Hôpital Robert Debré, Université Paris Cité (UPCité), AP-HP Hôpital universitaire Robert-Debré [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre hospitalier de Saint-Nazaire, Centre hospitalier universitaire de Nantes (CHU Nantes), CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sorbonne Université (SU), Marseille medical genetics - Centre de génétique médicale de Marseille (MMG), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de génétique médicale [Hôpital de la Timone - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE)-Institut National de la Santé et de la Recherche Médicale (INSERM), HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666 (HEMATIM), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Amiens-Picardie, Rapetti-Mauss, Raphael, Bioinformatique génomique et moléculaire ((U 726)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Institute of Developmental Biology and Cancer (IBDC), and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)

Subjects
[SDV] Life Sciences [q-bio], Gardos, [SDV]Life Sciences [q-bio], Hereditary Xerocytosis, Stomatocytosis, red blood cell, KCNN4, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; The K + channel activated by the Ca 2+ , KCNN4, has been shown to contribute to red blood cell dehydration in the rare hereditary hemolytic anemia, the dehydrated hereditary stomatocytosis. We report two de novo mutations on KCNN4 , We reported two de novo mutations on KCNN4 , V222L and H340N, characterized at the molecular, cellular and clinical levels. Whereas both mutations were shown to increase the calcium sensitivity of the K + channel, leading to channel opening for lower calcium concentrations compared to WT KCNN4 channel, there was no obvious red blood cell dehydration in patients carrying one or the other mutation. The clinical phenotype was greatly different between carriers of the mutated gene ranging from severe anemia for one patient to a single episode of anemia for the other patient or no documented sign of anemia for the parents who also carried the mutation. These data compared to already published KCNN4 mutations question the role of KCNN4 gain-of-function mutations in hydration status and viability of red blood cells in bloodstream.

Published
2022
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31. Patient and Treatment Characteristics Associated With Receipt of Core Patient-Reported Outcome Measures in VA Mental Health

Author

Edward P Liebmann, Sandra G Resnick, Karen L Austin, and Jenefer M Jedele

Subjects
Public Health, Environmental and Occupational Health, General Medicine
Abstract

Objective Measurement-based care (MBC) has been implemented in Veterans Affairs since 2016 and is increasingly used in other mental health care organizations. Little quantitative research exists that assesses patient-level barriers and facilitators of MBC. This study examines correlates of receiving patient-reported outcome measures (PROMs) among veterans receiving both psychotherapy and pharmacotherapy (Both), psychotherapy only (Psychotherapy), and pharmacotherapy only (Pharmacotherapy). Methods Data on PROM administration were obtained for a 12-month period for 1,726,578 veterans who initiated outpatient mental health care during fiscal year 2019. Clinical, treatment, and PROM data were extracted from the electronic health record. Logistic regression was used to model the association between veteran and treatment characteristics and PROM administration. Results Thirty-two percent of veterans in Both, 26.0% in Psychotherapy, and 8.8% in Pharmacotherapy received at least one PROM. The probability of PROM administration was positively associated with the number of treatment encounters during the fiscal year 2019. Major depressive, generalized anxiety, and other depressive disorders were associated with an increased probability of PROM administration. Psychotic disorders, personality disorders, older age, dementia, and electronic health record suicide risk flag were associated with decreased odds of PROM administration across treatment types. Conclusions Rates of PROM administration differ depending on the type of treatment received. The probability of PROM administration is influenced by the frequency of encounters and, to a lesser extent, having a diagnosis congruent with symptoms assessed in the set of PROMs considered. Consistent with hypotheses from the MBC implementation literature, potential indicators of clinical severity and cognitive impairment decrease the likelihood of PROM utilization.

Published
2022
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44. Critical Periods for Increased Mortality After Discharge From Inpatient Mental Health Units: Opportunities for Prevention

Author

Ira R. Katz, John F. McCarthy, Talya Peltzman, and Jenefer M. Jedele

Subjects
medicine.medical_specialty, business.industry, After discharge, Mental health, humanities, 030227 psychiatry, 03 medical and health sciences, Psychiatry and Mental health, 0302 clinical medicine, Emergency medicine, medicine, 030212 general & internal medicine, business, Veterans Affairs
Abstract

Objective:Studies of patients in the U.S. Department of Veterans Affairs (VA) health system and elsewhere have documented elevated mortality from suicide during a critical period within 30 to 90 da...

Published
2019
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45. Impact of an interdisciplinary intervention for distress behaviors in dementia on psychotropic drug use in Veterans Health Administration Community Living Centers: STAR-VA impact on psychotropic drug utilization

Author

Kevin W, McConeghy, Kim, Curyto, Jenefer, Jedele, Orna, Intrator, David C, Mohr, Ilse R, Wiechers, and Michele J, Karel

Subjects
Psychotropic Drugs, Humans, Veterans Health, Dementia, Drug Utilization, Retrospective Studies
Abstract

STAR-VA is an interdisciplinary behavioral approach for managing distress behaviors in residents with dementia, implemented at Veterans Health Administration nursing homes. This study evaluated the impact of STAR-VA implementation on psychotropic drug use. The study design is a retrospective, quasi-experimental cohort analysis of residents enrolled as STAR-VA training cases compared with eligible residents at untrained sites to evaluate treatment effects on psychotropic medication use. We matched 229 STAR-VA cases with 1,163 comparisons. STAR-VA cases experienced an average reduction of 0.92 "as-needed" doses per month (95% confidence interval [CI] -1.82, -0.02) compared with controls. No significant effect on non-STAR-VA cases in trained facilities was detected. STAR-VA programs are an important option for reducing potentially inappropriate psychotropic use.

Published
2021

46. Access to timely mental health care treatment initiation among Veterans Health Administration patients with and without serious mental illness

Author

Jenefer Jedele, Kristen M. Abraham, Nicholas W. Bowersox, Tyler C. Hein, Sharon M. Nelson, and Jennifer Mach

Subjects
medicine.medical_specialty, Substance-Related Disorders, medicine.medical_treatment, education, Veterans Health, PsycINFO, Stress Disorders, Post-Traumatic, mental disorders, Medicine, Humans, Psychiatry, health care economics and organizations, Applied Psychology, Veterans, Rehabilitation, business.industry, Mental Disorders, Veterans health, Mental illness, medicine.disease, Mental health, United States, Substance abuse, Clinical Psychology, United States Department of Veterans Affairs, Mental Health, Mental health care, business, Psychosocial
Abstract

Timely care initiation is a priority within the Veterans Health Administration (VHA). Patients with serious mental illnesses (SMI) are a group that benefits from timely care initiation due to elevated risks of negative outcomes with delayed care. However, no evaluation has assessed whether VHA SMI patients disproportionately experience delays in mental health care initiation. VHA administrative care data were used to compare delays in mental health care initiation for VHA patients with and without SMI who had newly identified mental health needs. Analyses assessed rates of delayed initial mental health appointments within five settings (General Mental Health [GMH], Primary Care Mental Health Integration [PC-MHI], Post-Traumatic Stress Disorder [PTSD], Substance Use Disorder [SUD], and Psychosocial Rehabilitation clinics [PSR]). SMI patients were more likely to receive delayed initial appointments in three of five clinical settings (PTSD, SUD, PSR) and had significantly longer average wait times for an initial appointment when referred to the PTSD clinic for an initial appointment. Overall, SMI patients were equally as likely to receive delayed initial appointments. While VHA SMI patients were not more likely to experience delayed mental health care initiation overall, they were more likely to experience delays within three of the five treatment settings. Findings suggest that the majority of VHA SMI patients experience equivalent timeliness, though those with more complex needs, and particularly those with trauma-related care needs, may be more likely to experience treatment initiation delays. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Published
2021

47. SchussenAktivplus: reduction of micropollutants and of potentially pathogenic bacteria for further water quality improvement of the river Schussen, a tributary of Lake Constance, Germany

Author

Triebskorn, Rita, Amler, Klaus, Blaha, Ludek, Gallert, Claudia, Giebner, Sabrina, Güde, Hans, Henneberg, Anja, Hess, Stefanie, Hetzenauer, Harald, Jedele, Klaus, Jung, Ralph-Michael, Kneipp, Sven, Köhler, Heinz-R, Krais, Stefanie, Kuch, Bertram, Lange, Claudia, Löffler, Herbert, Maier, Diana, Metzger, Jörg, Müller, Michael, Oehlmann, Jörg, Osterauer, Raphaela, Peschke, Katharina, Raizner, Jürgen, Rey, Peter, Rault, Magali, Richter, Doreen, Sacher, Frank, Scheurer, Marco, Schneider-Rapp, Jutta, Seifan, Merav, Spieth, Markus, Vogel, Hans-Joachim, Weyhmüller, Michael, Winter, Josef, and Wurm, Karl

Published
2013
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49. Correlation between time and angular alignment in molecular dynamics simulations of heavy ion collisions

Author

Lauren A. McIntosh, R. Wada, Y.-W. Lui, Andrew Hannaman, Zachary Tobin, M. Sorensen, Mike Youngs, A. Rodriguez Manso, K. Hagel, Sherry Yennello, K. Krieble, A. Jedele, Alan McIntosh, A. Hood, B. Harvey, J. Gauthier, A. Zarrella, and A. Abbott

Subjects
Physics, Molecular dynamics, Linear relationship, 010308 nuclear & particles physics, 0103 physical sciences, Heavy ion, Atomic physics, Nuclear Experiment, 010306 general physics, Nucleon, 01 natural sciences, Energy (signal processing)
Abstract

Neutron-proton equilibration is a process which has been used to study the density dependence of the symmetry energy term in the nuclear equation-of-state. This study utilizes constrained molecular dynamics (CoMD) simulations of $^{70}\mathrm{Zn}\phantom{\rule{4pt}{0ex}}+\phantom{\rule{4pt}{0ex}}^{70}\mathrm{Zn}$ with collision energies of 35 and 45 MeV/nucleon. An algorithm is used which searches through CoMD events and identifies the PLF* after it separates from the target and determines its lifetime, $\mathrm{\ensuremath{\Delta}}t$. It also determines the fragments that the PLF* breaks apart into and determines their angular alignment. This technique gives an opportunity to explore how the average alignment of dynamically produced fragments, ${\ensuremath{\langle}\ensuremath{\alpha}\ensuremath{\rangle}}_{\mathrm{dyn}}$, evolves with PLF* lifetime. An approximately linear relationship was determined with $d{\ensuremath{\langle}\ensuremath{\alpha}\ensuremath{\rangle}}_{\mathrm{dyn}}/d\mathrm{\ensuremath{\Delta}}t=0.98\ifmmode\pm\else\textpm\fi{}0.08\phantom{\rule{0.16em}{0ex}}\mathrm{rad}/\mathrm{zs}$ and $1.06\ifmmode\pm\else\textpm\fi{}0.09\phantom{\rule{0.16em}{0ex}}\mathrm{rad}/\mathrm{zs}$ for the 35 and $45\phantom{\rule{0.16em}{0ex}}\mathrm{MeV}/\mathrm{nucleon}$, respectively, indicating a correlation with magnitude consistent with classically determined values which were used for prior experimental studies.

Published
2020
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50. An MDS 3.0 Distressed Behavior in Dementia Indicator (DBDI): A Clinical Tool to Capture Change

Author

Orna Intrator, David C. Mohr, Jenefer M. Jedele, Michele J. Karel, Kim Curyto, and April Eaker

Subjects
Change over time, Male, Quality management, Risk Assessment, Article, 03 medical and health sciences, 0302 clinical medicine, Intervention (counseling), Medicine, Dementia, Humans, 030212 general & internal medicine, Psychomotor Agitation, Aged, Skilled Nursing Facilities, Veterans, Change score, Aged, 80 and over, Minimum Data Set, 030214 geriatrics, business.industry, Reproducibility of Results, medicine.disease, United States, Distress, Female, Geriatrics and Gerontology, Nursing homes, business, Clinical psychology
Abstract

Background/objectives Persons with dementia frequently demonstrate distress behaviors in dementia (DBD), associated with poorer outcomes. This study aimed to create a measure of DBD from routinely administered Minimum Data Set (MDS 3.0) behavior section items that demonstrated sensitivity to change, for evaluation of intervention efforts for VA Community Living Center (CLCs) residents exhibiting DBD. Setting 72 VA nursing home settings, or Community Living Centers (CLCs). Participants CLC residents with DBD (n = 302) were enrolled in an interdisciplinary behavioral intervention between 2013 and 2017. Design A factor analysis of MDS behavior section items from assessments closest to baseline was conducted. Internal consistency, hypothesized associations between MDS factors and clinical measures, and sensitivity to detect change over time was explored. Measurements Residents were assessed at baseline and post-intervention using the MDS behavior section items and a validated clinical measure of DBD. Results The Distress Behavior in Dementia Indicator (DBDI) was created as a consistent factor with internal consistency, and was related to a validated measure as predicted at baseline and post-intervention. Sensitivity to change was demonstrated by using change score correlations (r = 0.40-0.50), effect size (d = 0.63), and reliable change indices. Conclusion The DBDI is recommended for routine use in CLCs to evaluate impact of intervention effectiveness and provide quality improvement feedback.

Published
2020

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