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The raccoon dog (Nyctereutes procyonoides) is a representative of Canidae and is closely related to red fox-like canids, although the species exhibits high distinctiveness in the family. These animals were farmed for fur products, but thousands were intentionally released into the wild in western Russia. This newly established alien species in Europe has spread rapidly into many European countries. The aim of the study was to determine the origin of Polish populations by comparing the mitochondrial molecular marker cytochrome b (cytb) sequences of Polish wild and farm individuals with wild raccoon dogs from the western Russia and Asian specimens whose sequences were obtained from GenBank resources. The results of our phylogenetic analysis support the previous suggestions on the existence of two main clades clearly referring to continental and Island populations. Polish individuals were classified into a highly diverse continental group. The relationships between the haplotypes within the clade together with estimated values of genetic diversity parameters indicate that the Polish raccoon dog populations exhibit high genetic similarity to the Russian population. In combination with the history of introduction of the species to Europe, this suggests the most probable assignment of the Polish populations to the subspecies N. procyonoides ussuriensis. Our results indicate the presence of two Japanese haplotypes within the continental group, which is inconsistent with the assumed scenario of post-glacial expansion of raccoon dogs excluding gene flow between continental and Island populations.

Fatigue is a significant problem in patients with bladder cancer treated by radical cystectomy. This pilot study evaluated fatigue and related variables during a treatment period. Four measurements were made, the first 1 month after the cystectomy, and the next three at an interval of about 3 months each (at 4 months, 7 months, and 10 months after the surgery). In addition to the author's questionnaire (sociodemographic variables and a question about the impact of the disease on the patient's life), the FACIT-F Fatigue (to measure fatigue), NCCN/FACT FBISI-18, version 2 (symptoms, general condition of the patient), HADS (depression, anxiety, and irritability) measures were used. In this study, 21 patients participated in all four measurement periods. The fatigue intensity increased significantly between the first and second measurements and gradually decreased between the third and fourth measurements.As the severity of fatigue increases, can be observed an increase in the sense of the impact of the disease on the patient's life in all except the first measurement.The study revealed statistically significant correlations between fatigue and experiencing symptoms of cancer and treatment at each stage of the study, with the strongest correlations in the second and fourth measurements regarding symptoms of cancer and a stronger correlation in the second compared to the first measurement regarding side effects. At each stage of measurement, the experience of dizziness, lack of appetite, feeling of being sick, and feeling of annoyance from treatment side effects were statistically significantly correlated with fatigue. The intensity of fatigue correlated with the feeling of experiencing difficulties in meeting the needs of the family due to the physical condition in the first measurement (Rho = 0.76), a sense of weakness (Rho = 0.92) and sleepiness (Rho = 0.72) in the second measurement, pain in the third (Rho = 0.77). The greatest number of correlates of fatigue were described in the fourth measurement (all symptoms of cancer and side effects except losing weight).Stress, anxiety, depression and irritability were correlated with fatigue at each of the stages of research except the first one (without differences between the correlation coefficients in the second, third and fourth measurements). Significantly lower levels of fatigue characterised patients who survived over 6 months after the end of the study compared to the first three measurements.

Beads made of sodium alginate, whey protein concentrate, and red grape seed extract powder were exposed to white light and its red-orange, yellow-green-cyan, and cyan-blue-violet bands. The chemical analysis showed that encapsulation in the alginate–whey protein matrix protected polyphenols, flavonoids and cyanidin-3-O-glucoside when exposed to red-orange light. The reflectance spectra acquired from grape seed extract powder and grape seed extract beads were deconvoluted and anthocyanins-based moieties which contribute to the expression of bathochromic or hypsochromic effects were identified. The evolution of the peak areas assigned to the colored compounds confirms that the most intense polyphenol degradation occurred in grape seed extract powder and grape seed extract beads exposed to cyan-blue-violet light, as shown by the chemical analysis. The results of the study are important in choosing the light band from the visible spectrum which can be used to process food enriched with grape seed extract with minimal polyphenol degradation.

Background: Psoriasis is a chronic, multisystemic, inflammatory disease affecting approximately 1% of children and significantly reducing their health-related quality of life. Etanercept is a biologic fusion protein-blocking TNF-α and belongs to one of the biologics used among the children population. The purpose of this study was to assess the effectiveness and safety profile of etanercept in paediatric patients with plaque-type psoriasis. Material and methods: The outcome of the treatment was evaluated based on Psoriasis Area and Severity Index (PASI), Body Surface Area (BSA), and Children’s Dermatology Life Quality Index (CDLQI). Achievement of at least PASI75 at week 16 was assessed as an adequate response to therapy, which was the primary endpoint. Results: Forty-three paediatric patients were included in the study, 24 females and 19 males. The average age at inclusion into our study was 13 years. At baseline, the mean PASI score, BSA, and CDLQI were 16.3 ± 6.5, 22.3 ± 12.2%, and 17.4 ± 5.3, respectively. At week 16, 90.7% of patients achieved PASI 50, 79.1% achieved PASI 75, and 46.5% attained PASI 90. There was also a decrease in mean BSA and CDLQI values to 3.5 ± 3.8 and 5.4 ± 5.7, respectively. Conclusions: Etanercept proved to be effective, safe, and well-tolerated among the paediatric population with psoriasis.

Both the Russian hybrid activities and warfare include the use of genocide to strengthen the Krem­lin’s position and overcome Ukrainians. It can be observed within many spheres, but mainly as the Russian Federation falsely accuses Ukraine of committing genocide against Russians and claims that the West supports it. Russians commit war crimes that fulfil all the requirements to be considered genocide. The Kremlin uses genocide as a part of cognitive warfare, trying to influence not only the way the Ukrainians are thinking but also how they are behaving. In unofficial channels, there is much content showing Russian violence to generate fear and diminish the resilience of Ukrainians. Bearing in mind how much Russia has already lost with respect to the hybrid war in Ukraine, it is more and more likely that the Kremlin will focus in the future on hybrid activities and will try to exploit the potential of the threats that have already materialised. Principally, the hybrid warfare potential of genocide has been explored by Russians to various extend. This work addresses chosen aspects of the use of genocide by the Russian Federation in the conduct of hy­brid activities and warfare in Ukraine from 2022, as well as the motivation behind it.

Państwo, jako instytucja, jest zawsze głównym gwarantem każdego rodzaju bezpieczeń-stwa, ale to społeczeństwo jest podstawowym podmiotem i przedmiotem wszelkich przyj-mowanych rozwiązań instytucjonalnych. Ciągła interakcja między państwem a jego obywate-lami jest warunkiem sine qua non bezpiecznego funkcjonowania każdego systemu demokra-tycznego. Priorytetową rolą tegoż jest ochrona egzystencjalnych podstaw życia ludzi oraz gwarancja realizacji ich potrzeb i aspiracji życiowych oraz rozwoju. Należy do niej także bu-dowanie postaw społecznej aktywności i zaangażowania w tworzenie warunków bezpiecznej egzystencji, zarówno jednostek, jak i całych grup społecznych. Szczególną strukturą, w ra-mach której jednostki uczą się kreatywności i nabywają umiejętności zaspokajania potrzeb i realizowania interesów, nie tylko w wymiarze indywidualnym, ale również wspólnotowym, jest społeczeństwo obywatelskie. Jest to wspólnota osób, które wykorzystują swój osobisty kapitał (intelektualny, ekonomiczny, społeczny) w celu zaspokajania zbiorowych interesów i budowania wspólnego dobra. Wspólnotowość społeczna urzeczywistnia się najwyraźniej w powoływaniu do życia organizacji pozarządowych, czyli zrzeszeń ludzi dobrowolnie działają-cych w imię realizacji interesu publicznego. Praktyczny wymiar działalności organizacji poza-rządowych sprowadza się przede wszystkim do świadczenia usług, których ani państwo, ani rynek nie są w stanie lub nie chcą realizować. Trzeci sektor stanowi zatem istotny element zaspokajania potrzeby bezpieczeństwa, także społecznego. Celem artykułu jest zdiagnozo-wanie stanu polskiego sektora społecznego oraz roli, jaką odgrywają organizacje pozarządowe w tworzeniu bezpieczeństwa społecznego w Polsce, po transformacji systemowej w 1989 roku. W artykule odwołano się w analizach głównie do treści dostępnej literatury przedmiotu. Wykorzystano także dostępne materiały źródłowe oraz istniejące akty prawne. Zanalizowano wyniki badań dotyczących funkcjonowania trzeciego sektora w Polsce, prowadzone przez niezależne instytucje badawcze skupione od wielu lat na problematyce jego działalności.

Nicotinamide (NA) derivatives play crucial roles in various biological processes, such as inflammation, regulation of the cell cycle, and DNA repair. Recently, we proposed that 4-pyridone-3-carboxamide-1-β-D-ribonucleoside (4PYR), an unusual derivative of NA, could be classified as an oncometabolite in bladder, breast, and lung cancer. In this study, we investigated the relations between NA metabolism and the progression, recurrence, metastasis, and survival of patients diagnosed with different histological subtypes of renal cell carcinoma (RCC). We identified alterations in plasma NA metabolism, particularly in the clear cell RCC (ccRCC) subtype, compared to papillary RCC, chromophobe RCC, and oncocytoma. Patients with ccRCC also exhibited larger tumor sizes and elevated levels of diagnostic serum biomarkers, such as hsCRP concentration and ALP activity, which were positively correlated with the plasma 4PYR. Notably, 4PYR levels were elevated in advanced stages of ccRCC cancer and were associated with a highly aggressive phenotype of ccRCC. Additionally, elevated concentrations of 4PYR were related to a higher likelihood of mortality, recurrence, and particularly metastasis in ccRCC. These findings are consistent with other studies, suggesting that NA metabolism is accelerated in RCC, leading to abnormal concentrations of 4PYR. This supports the concept of 4PYR as an oncometabolite and a potential prognostic factor in the ccRCC subtype.

The pandemic that broke out in 2019 had a significant impact on the lives of all social groups around the world. The imposed restrictions and mandatory quarantine were crucial to limit the virus’s spread. The research comprises an analysis of the psychosocial impact exerted by the pandemic that attempted to determine the response to the crisis caused by the COVID-19 pandemic and its aftermath. For this purpose, a study on social resilience in the pandemic era was worked out. The study consisted of several parts: stress and the sense of safety, education, trust and defined needs and the mass media in COVID-19. The research team decided to present the study’s results in a series of articles that will contribute to forming a complete picture of the community in the context of the analysed variables. The paper is the first in this series. It contains an analysis of variables intended to determine the level of the experienced sense of safety and its constituent, i.e., stress, and the identification of socio-demographic data strongly influencing the studied variables. The study comprised 559 individuals who were surveyed between May 2020 and November 2020 with the use of an online survey questionnaire. SPSS Statistics version 21.0 and PQStat were used to conduct statistical analyses and correlate and assess the correlation of responses. Also used were Chisquare, Fisher’s test and Pearson’s linear correlation coefficient. A logistic regression analysis was carried out for dichotomous variables. The results of the study indicate that the level of experienced stress is influenced by age, place of residence, gender and job security. The sense of safety is inversely correlated with stress, i.e., as stress increases, the sense of safety decreases, indicating a need to undertake appropriate measures to reduce stress. It may be interesting to compare the level of stress with, among other things, information retrieval from different sources. These results will be presented in the subsequent studies.

Introduction: Wistar Han rats are a preferred strain of rodents for general toxicology and safety pharmacology studies in drug development. In some of these studies, visual functional tests that assess for retinal toxicity are included as an additional endpoint. Although the influence of gender on human retinal function has been documented for more than 6 decades, preclinically it is still uncertain if there are differences in retinal function between naïve male and female Wistar Han rats.Methods: In this study, sex-related differences in the retinal function were quantified by analyzing electroretinography (ERG) in 7-9-week-old (n = 52 males and 51 females) and 21–23-week-old Wistar Han rats (n = 48 males and 51 females). Optokinetic tracking response, brainstem auditory evoked potential, ultrasonic vocalization and histology were tested and evaluated in a subset of animals to investigate the potential compensation mechanisms of spontaneous blindness.Results/Discussion: Absence of scotopic and photopic ERG responses was found in 13% of 7-9-week-old (7/52) and 19% of 21–23-week-old males (9/48), but none of female rats (0/51). The averaged amplitudes of rod- and cone-mediated ERG b-wave responses obtained from males were significantly smaller than the amplitudes of the same responses from age-matched females (−43% and −26%, respectively) at 7–9 weeks of age. There was no difference in the retinal and brain morphology, brainstem auditory responses, or ultrasonic vocalizations between the animals with normal and abnormal ERGs at 21–23 weeks of age. In summary, male Wistar Han rats had altered retinal responses, including a complete lack of responses to test flash stimuli (i.e., blindness), when compared with female rats at 7–9 and 21–23 weeks of age. Therefore, sex differences should be considered when using Wistar Han rats in toxicity and safety pharmacology studies with regards to data interpretation of retinal functional assessments.

The effects of physical factors such as radiation (electromagnetic, microwave, infrared, laser, UVC, and X-ray) and high temperature, as well as chemical factors (controlled atmosphere) on the level of global DNA cytosine methylation in C. albicans ATCC 10231 cells were investigated. Prolonged exposure to each type of radiation significantly increased the DNA methylation level. In addition, the global methylation level in C. albicans cells increased with the incubation temperature. An increase in the percentage of methylated DNA was also noted in C. albicans cells cultured in an atmosphere with reduced O2. In contrast, in an atmosphere containing more than 3% CO2 and in anaerobic conditions, the DNA methylation level decreased relative to the control. This study showed that prolonged exposure to various types of radiation and high temperature as well as reduced O2 in the atmosphere caused a significant increase in the global DNA methylation level. This is most likely a response protecting DNA against damage, which at the same time can lead to epigenetic disorders, and in consequence can adversely affect the functioning of the organism.

Preview: /Commentary: Richard Shusterman, Ars Erotica: Sex and Somaesthetics in the Classical Arts of Love (Cambridge: Cambridge University Press, 2021), 436 pages./ Somaesthetics, the field cultivated by Richard Shusterman since 1997, bore another juicy fruit for our enjoyment. This time, his interdisciplinary research – integrating the theoretical, empirical, and practical disciplines related to bodily perception, presentation, and performance – resulted in an excellent cross-cultural study of the classical arts of love developed over centuries in such traditions as the Greco-Roman, Chinese, Indian, Muslim, Medieval and European Renaissance. Somaesthetic methodology provides fertile ground for such a comparative inquiry by encouraging new ways to understand the cultural dimension of human sexuality. It complements the popular 4EC perspectives applied in cognitive science which explore cognition as embodied, embedded, enactive, and expanded: emphasizing our bodily interaction with the physical and social environment. Shusterman’s analysis of the classical arts of love as aesthetically refining sexual experience gives due acknowledgement to our somatic and sensual, but also emotional and imagery engagement in the world, commonly neglected in modern philosophy.