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The “Color Circle” is an important chromatic Gestalt in the visual arts. There is not really a formal equivalent in conventional colorimetry. The fact that the hues can be linearly ordered and that such an order is necessarily periodic was intuited by artists in the early 19th century, but only formally explained by Ostwald and later Schrödinger a century later. As with musical keys, various metrical orders are in common use. Is there such a thing as a “well tempered” order? We consider this an issue for experimental phenomenology. We discuss an attempt based on observations by 30 (nonartist) observers.

Introduction and Objectives: Hepatic encephalopathy (HE) is a frequent complication of cirrhosis and may cause cerebral damage. Neurodegenerative diseases can induce the release of neuroproteins like neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) in body fluids, including blood plasma. We investigated whether NfL and GFAP could serve as potential diagnostic plasma biomarkers for overt HE (oHE). Materials and Methods: We included 85 patients from three prospective cohorts with different stages of liver disease and HE severity. The following patients were included: 1) 34 patients with primary sclerosing cholangitis (PSC) with compensated disease; 2) 17 patients with advanced liver disease without oHE before elective transjugular intrahepatic portosystemic shunt (TIPS) placement; 3) 17 intensive care unit (ICU) patients with oHE and 17 ICU patients without cirrhosis or oHE. Plasma NfL and GFAP were measured using single molecule assays. Results: ICU oHE patients had higher NfL concentrations compared to pre-TIPS patients or ICU controls (p < 0.05, each). Median GFAP concentrations were equal in the ICU oHE and pre-TIPS patients or ICU controls. Plasma NfL and GFAP concentrations correlated with Model for End-Stage Liver Disease (MELD) scores (R = 0.58 and R = 0.40, p < 0.001, each). Conclusions: Plasma NfL deserves further evaluation as potential diagnostic biomarker for oHE and correlates with the MELD score.

Climate adaptation and water management, in particular flood risk management (FRM), in the Netherlands are strongly integrated policy domains. The observed and expected effects of climate change in the Netherlands will create a variety of pressures, particularly in relation to sea-level rise, increasing river discharges and changing precipitation patterns. Whereas the focus in the Netherlands until recently was mainly and successfully on minimizing the probability of flooding (‘the fight against water’) and preparedness in case of a flood threat, in the course of time other strategies aimed at mitigating the effects of potential floods have gained a more prominent position (‘living with water’). As a result, FRM measures increasingly demand more space and more diverse actors became involved in Dutch FRM. This has increased complexity and fragmentation in the responsibilities for Dutch FRM, which resulted in an increasing need for communication, coordination and collaboration between different public and private actors in order to secure the effectiveness of FRM.

In urban environments, humans often encounter other people that may engage one in interaction. How do humans perceive such invitations to interact at a glance? We briefly presented participants with pictures of actors carrying out one of 11 behaviors (e.g., waving or looking at a phone) at four camera-actor distances. Participants were asked to describe what they might do in such a situation, how they decided, and what stood out most in the photograph. In addition, participants rated how likely they deemed interaction to take place. Participants formulated clear responses about how they might act. We show convincingly that what participants would do depended on the depicted behavior, but not the camera-actor distance. The likeliness to interact ratings depended both on the depicted behavior and the camera-actor distance. We conclude that humans perceive the “gist” of photographs and that various aspects of the actor, action, and context depicted in photographs are subjectively available at a glance. Our conclusions are discussed in the context of scene perception, social robotics, and intercultural differences.

Around the globe, coastal communities are increasingly coping with changing environmental conditions as a result of climate change and ocean acidification, including sea level rise, more severe storms, and decreasing natural resources and ecosystem services. A natural adaptation response is to engineer the coast in a perilous and often doomed attempt to preserve the status quo. In the long term, however, most coastal nations will need to transition to approaches based on ecological resilience—that is, to coastal zone management that allows coastal communities to absorb and adapt to change rather than to resist it—and the law will be critical in facilitating this transition. Researchers are increasingly illuminating law's ability to promote social-ecological resilience to a changing world, but this scholarship—mostly focused on U.S. law—has not yet embraced its potential role in helping to create new international norms for social-ecological resilience. Through its comparison of coastal zone management in Australia, Finland, and the Netherlands, this article demonstrates that a comparative law approach offers a fruitful expansion of law-and-resilience research, both by extending this research to other countries and, more importantly, by allowing scholars to identify critical variables, or variable constellations associated with countries' decisions to adopt laws designed to promote social-ecological resilience and to identify mechanisms that allow for a smoother transition to this approach. For example, our comparison demonstrates, among other things, that countries can adopt coastal zone management techniques that integrate social-ecological resilience without fully abandoning more traditional engineering approaches to adapt to environmental change and its impacts.

Patients with hepatocellular carcinoma (HCC) face a common type of cancer, which is amongst the most deadly types of cancer worldwide. The therapeutic options range from curative resection or ablation to loco regional therapies in palliative setting and last but not least, systemic treatment. The latter group underwent major changes in the last decade and a half. Since the introduction of sorafenib in 2007, many other systemic treatments have been investigated. Most without success. It took more than ten years before lenvatinib could be added as alternative first-line treatment option. Just recently a new form of systemic treatment, immunotherapy, entered the field of therapeutic options in patients with HCC. Immune checkpoint inhibitors are becoming the new standard of care in patients with HCC. Several reviews reported on the latest phase 1/2 studies and discussed the higher response rates and better tolerability when compared to current standard of care therapies. This review will focus on elaborating the working mechanism of these checkpoint inhibitors, give an elaborate update of the therapeutic agents that are currently available or under research, and will give an overview of the latest trials, as well as ongoing and upcoming trials.

We studied whether human observers can estimate the illumination direction from 3D textures of random Brownian surfaces, containing undulations over a range of scales. The locally Lambertian surfaces were illuminated with a collimated beam from random directions. The surfaces had a uniform albedo and thus texture appeared only through shading and shadowing. The data confirm earlier results with Gaussian surfaces, containing undulations of a single scale. Observers were able to accurately estimate the source azimuth. If shading dominated the images, the observers committed 180° errors. If cast shadows were present, they resolved this convex-concave-ambiguity almost completely. Thus, observers relied on second-order statistics in the shading regime and used an unidentified first-order cue in the shadow regime. The source elevations could also be estimated, which can be explained by the observers’ exploitation of the statistical homogeneity of the stimulus set. The fraction of the surface that is in shadow and the median intensity are likely cues for these elevation estimates.

Research on the influence of reference frames has generally focused on visual phenomena such as the oblique effect, the subjective visual vertical, the perceptual upright, and ambiguous figures. Another line of research concerns mental rotation studies in which participants had to discriminate between familiar or previously seen 2-D figures or pictures of 3-D objects and their rotated versions. In the present study, we disentangled the influence of the environmental and the viewer-centered reference frame, as classically done, by comparing the performances obtained in various picture and participant orientations. However, this time, the performance is the pictorial relief: the probed 3-D shape percept of the depicted object reconstructed from the local attitude settings of the participant. Comparisons between the pictorial reliefs based on different picture and participant orientations led to two major findings. First, in general, the pictorial reliefs were highly similar if the orientation of the depicted object was vertical with regard to the environmental or the viewer-centered reference frame. Second, a viewpoint-from-above interpretation could almost completely account for the shears occurring between the pictorial reliefs. More specifically, the shears could largely be considered as combinations of slants generated from the viewpoint-from-above, which was determined by the environmental as well as by the viewer-centered reference frame.