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This article adheres to UN guidelines concerning the Decade of Healthy Ageing (2021-2030) which aim to improve the lives of the older population. The objective of this study is to show how social dance with artistic-scenic purposes for a socially vulnerable group of older adults (third and fourth age) contributes to active ageing from social and health perspectives. The sample comes from a social group for the over-60s years and forms part of an artistic-community project in which participant observation has been carried out for five years. To obtain more data from the sample group, an "ad hoc" measurement instrument is developed based on a specific literature review on the topic. The results show that dance, group, and stage performance are a vital driver for members. The analysis shows that individual perspectives are higher than group perspectives. The research provides evidence that social dance groups improve motor expressiveness, stimulate the ability to think, memorize and create, among other aspects.

Background: Idiopathic Rapid eye movement sleep behavior disorder (IRBD) is recognized as the prodromal stage of the alpha-Synucleinopathies. Although some studies have addressed the characterization of brain structure in IRBD, little is known about its progression. Objective: The present work aims at further characterizing gray matter progression throughout IRBD relative to normal aging and investigating how these changes are associated with cognitive decline. Methods: Fourteen patients with polysomnography-confirmed IRBD and 18 age-matched healthy controls (HC) underwent neuropsychological, olfactory, motor, and T1-weighted MRI evaluation at baseline and follow-up. We compared the evolution of cortical thickness (CTh), subcortical volumes, smell, motor and cognitive performance in IRBD and HC after a mean of 1.6 years. FreeSurfer was used for CTh and volumetry preprocessing and analyses. The symmetrized percent of change (SPC) of the CTh was correlated with the SPC of motor and neuropsychological performance. Results: IRBD and HC differed significantly in the cortical thinning progression in regions encompassing bilateral superior parietal and precuneus, the right cuneus, the left occipital pole and lateral orbitofrontal gyri (FWE corrected, p

Background: Resting-state functional MRI has been proposed as a new biomarker of prodromal neurodegenerative disorders, but it has been poorly investigated in the idiopathic form of rapid-eye-movement sleep behavior disorder (IRBD), a clinical harbinger of subsequent synucleinopathy. Particularly, a complex-network approach has not been tested to study brain functional connectivity in IRBD patients. Objectives: The aim of the current work is to characterize resting-state functional connectivity in IRBD patients using a complex-network approach and to determine its possible relation to cognitive impairment. Method: Twenty patients with IRBD and 27 matched healthy controls (HC) underwent resting-state functional MRI with a 3T scanner and a comprehensive neuropsychological battery. The functional connectome was studied using threshold-free network-based statistics. Global and local network parameters were calculated based on graph theory and compared between groups. Head motion, age and sex were introduced as covariates in all analyses. Results: IRBD patients showed reduced cortico-cortical functional connectivity strength in comparison with HC in edges located in posterior regions (p

Abstract One of the most captivating properties of polaritons is their capacity to confine light at the nanoscale. This confinement is even more extreme in two-dimensional (2D) materials. 2D polaritons have been investigated by optical measurements using an external photodetector. However, their effective spectrally resolved electrical detection via far-field excitation remains unexplored. This hinders their exploitation in crucial applications such as sensing, hyperspectral imaging, and optical spectrometry, banking on their potential for integration with silicon technologies. Herein, we present the electrical spectroscopy of polaritonic nanoresonators based on a high-quality 2D-material heterostructure, which serves at the same time as the photodetector and the polaritonic platform. Subsequently, we electrically detect these mid-infrared resonators by near-field coupling to a graphene pn-junction. The nanoresonators simultaneously exhibit extreme lateral confinement and high-quality factors. This work opens a venue for investigating this tunable and complex hybrid system and its use in compact sensing and imaging platforms.

Objective. To determine potential mitochondrial and oxidative alterations in colon biopsies from idiopathic REM sleep behavior disorder (iRBD) and Parkinson’s disease (PD) subjects. Methods. Colonic biopsies from 7 iRBD subjects, 9 subjects with clinically diagnosed PD, and 9 healthy controls were homogenized in 5% w/v mannitol. Citrate synthase (CS) and complex I (CI) were analyzed spectrophotometrically. Oxidative damage was assessed either by lipid peroxidation, through malondialdehyde and hydroxyalkenal content by spectrophotometry, or through antioxidant enzyme levels of superoxide dismutase-2 (SOD2), glutathione peroxidase-1 (Gpx1), and catalase (CAT) by western blot. The presence of mitochondrial DNA (mtDNA) deletions was assessed by long PCR and electrophoresis. Results. Nonsignificant trends to CI decrease in both iRBD (45.69±18.15; 23% decrease) and PD patients (37.57±12.41; 37% decrease) were found compared to controls (59.51±12.52, p: NS). Lipid peroxidation was maintained among groups (iRBD: 27.46±3.04, PD: 37.2±3.92, and controls: 31.71±3.94; p: NS). Antioxidant enzymes SOD2 (iRBD: 2.30±0.92, PD: 1.48±0.39, and controls: 1.09±0.318) and Gpx1 (iRBD 0.29±0.12, PD: 0.56±0.33, and controls: 0.38±0.16) did not show significant differences between groups. CAT was only detected in 2 controls and 1 iRBD subject. One iRBD patient presented a single mtDNA deletion.

Resumen: Introducción: El objetivo de nuestro trabajo es describir 4 casos de sexsomnia, una parasomnia caracterizada por conductas sexuales durante el sueño. Método: Historia clínica y registro videopolisomnográfico de pacientes identificados en la unidad multidisciplinaria del sueño del Hospital Clínic de Barcelona. Resultados: Tres varones y una mujer entre 28 y 43 años de edad referían conductas sexuales durante el sueño de entre 9 meses y 7 años de evolución. Consistían en la masturbación sin buscar la participación de la pareja, que dormía en la misma cama (2 casos), e intentar el coito con vigorosidad conductual y verbal inapropiada e inhabitual (3 casos). La frecuencia era variable entre 4 únicos episodios y 2-3 semanales. Los pacientes presentaban amnesia completa de los eventos y sorpresa cuando se les explicaba lo que habían hecho. Había antecedentes de sonambulismo (un caso), despertares confusos (2 casos) y somniloquia (un caso). Los registros polisomnográficos con vídeo no detectaron conductas sexuales pero registraron apneas (2 casos) y movimientos periódicos de las piernas (un caso). En el único paciente en que se probó clonacepam la frecuencia de la sexsomnia y los despertares confusos disminuyó. Conclusión: La sexsomnia aparece en el adulto joven, consiste en intentar consumar de forma inapropiada el coito o masturbarse durante el sueño, con amnesia posterior de lo ocurrido. Puede coexistir con otras parasomnias, como sonambulismo y despertares confusos. Otros trastornos del sueño, como las apneas y los movimientos periódicos de las piernas, podrían desencadenar los episodios de sexsomnia. Abstract: Introduction: The purpose of our study is to describe 4 cases of sexsomnia, a form of parasomnia characterised by sexual behaviour during sleep. Methods: Clinical history and video-polysomnography recordings from patients diagnosed with sexsomnia in the Multidisciplinary Sleep Unit at Hospital Clínic in Barcelona. Results: Three men and one woman between 28 and 43 years of age reported sexual behaviours during sleep with progression times ranging from 9 months to 7 years. Episodes consisted of masturbation without seeking the participation of a sleeping partner (2 cases) and attempts at sexual intercourse with inappropriate and uncharacteristic vocalizations and behaviours (3 cases). The frequency of the episodes ranged from 4 isolated episodes to 2-3 per week. Patients were amnestic of these events and surprised by their partners’ accounts of their behaviour. Medical histories revealed that 1 patient was a somnambulist, 2 had confusional arousals, and 1 experienced somniloquy. Video-polysomnography did not disclose sexual behaviours during sleep but revealed sleep apnoea in 2 cases and periodic leg movements in sleep in another. The only patient treated with clonazepam reported decreased frequency of both confusional arousals and sexsomnia episodes. Conclusions: Sexsomnia occurs in young adults and is characterised by masturbation and inappropriate attempts at achieving sexual intercourse followed by total amnesia of the events. It can be associated with other parasomnias such as sleepwalking and confusional arousals. Other sleep disorders, including sleep apnoea and periodic leg movement disorder, may trigger episodes of sexsomnia. Palabras clave: Sexsomnia, Parasomnia, Masturbación, Coito, Amnesia y sueño, Keywords: Sexsomnia, Parasomnia, Masturbation, Intercourse, Amnesia and sleep

Introduction: The purpose of our study is to describe 4 cases of sexsomnia, a form of parasomnia characterised by sexual behaviour during sleep. Methods: Clinical history and video-polysomnography recordings from patients diagnosed with sexsomnia in the Multidisciplinary Sleep Unit at Hospital Clínic in Barcelona. Results: Three men and one woman between 28 and 43 years of age reported sexual behaviours during sleep with progression times ranging from 9 months to 7 years. Episodes consisted of masturbation without seeking the participation of a sleeping partner (2 cases) and attempts at sexual intercourse with inappropriate and uncharacteristic vocalisations and behaviours (3 cases). The frequency of the episodes ranged from 4 isolated episodes to 2-3 per week. Patients were amnestic of these events and surprised by their partners’ accounts of their behaviour. Medical histories revealed that 1 patient was a somnambulist, 2 had confusional arousals, and 1 experienced somniloquy. Video-polysomnography did not disclose sexual behaviours during sleep but revealed sleep apnoea in 2 cases and periodic leg movements in sleep in another. The only patient treated with clonazepam reported decreased frequency of both confusional arousals and sexsomnia episodes. Conclusions: Sexsomnia occurs in young adults and is characterised by masturbation and inappropriate attempts at achieving sexual intercourse followed by total amnesia of the events. It can be associated with other parasomnias such as sleepwalking and confusional arousals. Other sleep disorders, including sleep apnoea and periodic leg movement disorder, may trigger episodes of sexsomnia. Resumen: Introducción: El objetivo de nuestro trabajo es describir 4 casos de sexsomnia, una parasomnia caracterizada por conductas sexuales durante el sueño. Método: Historia clínica y registro videopolisomnográfico de pacientes identificados en la unidad multidisciplinaria del sueño del Hospital Clínic de Barcelona. Resultados: Tres varones y una mujer entre 28 y 43 años de edad referían conductas sexuales durante el sueño de entre 9 meses y 7 años de evolución. Consistían en la masturbación sin buscar la participación de la pareja, que dormía en la misma cama (2 casos), e intentar el coito con vigorosidad conductual y verbal inapropiada e inhabitual (3 casos). La frecuencia era variable entre 4 únicos episodios y 2-3 semanales. Los pacientes presentaban amnesia completa de los eventos y sorpresa cuando se les explicaba lo que habían hecho. Había antecedentes de sonambulismo (un caso), despertares confusos (2 casos) y somniloquia (un caso). Los registros polisomnográficos con vídeo no detectaron conductas sexuales pero registraron apneas (2 casos) y movimientos periódicos de las piernas (un caso). En el único paciente en que se probó clonacepam la frecuencia de la sexsomnia y los despertares confusos disminuyó. Conclusión: La sexsomnia aparece en el adulto joven, consiste en intentar consumar de forma inapropiada el coito o masturbarse durante el sueño, con amnesia posterior de lo ocurrido. Puede coexistir con otras parasomnias, como sonambulismo y despertares confusos. Otros trastornos del sueño, como las apneas y los movimientos periódicos de las piernas, podrían desencadenar los episodios de sexsomnia. Keywords: Sexsomnia, Parasomnia, Masturbation, Intercourse, Amnesia and sleep, Palabras clave: Sexsomnia, Parasomnia, Masturbación, Coito, Amnesia y sueño

Resumen: El presente artículo se plantea como una propedéutica al estudio del cómic ensayo o ensayo gráfico, desde su nacimiento con autoconsciencia hasta la actualidad. Con la voluntad de trazar una genealogía de obras significativas, el artículo incide en aquellos aspectos formales relacionados con estrategias de montaje que resultan relevantes en la forma-ensayo a partir de desarrollos de investigación en el campo del cine. Además, y de manera central, se propone una metodología, basada sobre todo en la iconología de Aby Warburg para el estudio del ensayo como fórmula didáctica y de transmisión de la tradición en el contexto de las formas de no ficción en el cómic. Abstract: This paper serves as an introduction to the study of the graphic essay or comic essay, tracing its evolution from its self-aware inception to the present day. With the intention of establishing a genealogy of significant works, the article emphasizes formal aspects related to montage strategies that are relevant to the essay form, drawing from research developments in the field of cinema. Furthermore, at its core, it proposes a methodology primarily based on Aby Warburg's iconology for the examination of the essay as a didactic formula and a means of transmitting tradition within the context of non-fiction forms in comics. comic; essay; iconology; editing; Aby Warburg.

Animation has been employed as a productive and subtle means to represent Post-Traumatic Stress Disorder (PTSD) and historical trauma. The aim of this article is to study the narrative, visual, and psycho-affective strategies of both phenomena through the films Flee (Jonas Poher Rasmussen, 2021), Waltz with Bashir (Ari Folman, 2008), and L'Image Manquante (Rithy Panh, 2013). The ability of animated images to reconstruct moments for which there is no visual testimony, as well as their capacity to evoke the experience of traumatic events, emerges as the center of a specific aesthetic approach to history, forming a type of cinema of the real (Zylberman, 2022). Contrary to the tradition of documentary and visual essay, there is a more frequent expressive use of evocative mechanisms, dreamlike images combined with archival material, and forms of re-enactment of real events that necessarily do not involve the use of actors. The evocation of painful experiences establishes a visual framework in which the viewer becomes the epicenter of the affective staging of trauma and PTSD, prioritizing poetic construction.

This article draws on the stimulus–organism–response (SOR) model to understand the role of negative emotions in the anti-brand behaviors of online users who consume snow sports brands. To this end, both the online social influence and the mediating effect of symbolic incongruence (stimulus) on the generation of negative emotions (anger, stress, frustration, fear, boredom and sadness) (organism), and how these influence the formation of negative customer brand engagement (nCBE) (response), are analyzed. The study also analyses the moderating effects of “level of expertise”, this makes it possible to capture differences in behaviors based on the profile of the users in each of the proposed relationships. Questionnaire responses of 400 ski and snowboard users over 18 years of age were analyzed using a quantitative methodology. The results obtained have important theoretical and practical implications, since they confirm that online social influences have both a direct and indirect (mediating) effect on negative emotions, which positively affects the nCBE of online users of snow sports brands. Significant differences in behavior based on experience level (moderation effect) were also found. The study proposes useful practical recommendations applicable in online environments that the extreme sports industry could use to neutralize/avoid highly detrimental consequences.

Abstract We investigated the biomarker profile of neurodegeneration, Alzheimer’s and Lewy body pathology in the CSF of 148 polysomnography-confirmed patients with isolated REM sleep behavior disorder (IRBD), a condition that precedes Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). We assessed misfolded α-synuclein (AS) by RT-QuIC assay, amyloid-beta peptides (Aβ42 and Aβ40), phosphorylated tau (p-tau), and total tau (t-tau) by CLEIA and neurofilament light chain (NfL) by ELISA. We detected AS in 75.3% of patients, pathologically decreased Aβ42/Aβ40 ratio in 22.5%, increased p-tau in 15.5%, increased t-tau in 14.9%, and elevated NfL in 14.7%. After a mean follow-up of 2.48 ± 2.75 years, 47 (38.1%) patients developed PD (n = 24) or DLB (n = 23). At CSF collection, AS positivity [HR 4.05 (1.26–12.99), p = 0.019], mild cognitive impairment [3.86 (1.96–7.61), p

Abstract Objective: The aim of this study is to compare stigmatizing attitudes, reported and intended behavior, and knowledge of mental illness between university students and the general population. Methods: An online cross-sectional observational study was conducted. The survey included sociodemographic data and validated stigma questionnaires (the Attribution Questionnaire [AQ-27], the Reported and Intended Behaviour Scale [RIBS], and the Mental Health Knowledge Schedule [MAKS]). Descriptive statistics, bivariate analyses, and multiple regression modeling were employed to analyze the data. Results: A total of 506 participants completed the survey, including 226 (44.7%) university students (61.1% women), and 280 (55.3%) individuals from the general population (69.3% women). For both groups, women and individuals who had lived with someone with mental health problems exhibited more positive attitudes (p < 0.05). University students reported greater knowledge of mental illness (p < 0.05) than the general population. After controlling for covariates, university students only scored higher than the general population in the blame factor of the AQ-27 (p < 0.05). Additionally, older participants from both groups exhibited higher levels of stigmatizing attitudes compared to those of a younger age. Conclusion: These findings suggest that university students exhibit similar levels of stigmatizing attitudes to the general population. Among both groups, female sex, older age, previous contact with individuals with mental illness, and greater knowledge of mental health are all associated with less stigma toward people with mental illness. Tailored interventions grounded in contact with mental illness have the potential to help reduce stigmatizing attitudes within both groups.

Resumen: Objetivo: Presentar cinco pacientes con trastornos conductuales durante el sueño, sin conciencia posterior de los mismos, inducidos por zolpidem. Métodos: Evaluación con un cuestionario diseñado para estudiar las características y las conductas realizadas durante el sueño por todos los pacientes. Resultados: Las conductas realizadas por los pacientes fueron muy variadas (telefonear, limpieza y labores del hogar, alimentar al perro o depilarse), aunque en todos los pacientes se recogieron conductas alimentarias inapropiadas. Todos sufrieron una ganancia ponderal importante, debido a su preferencia por alimentos hipercalóricos durante los episodios, que en una de las pacientes desembocó en una obesidad extrema. Dos de los pacientes sufrieron lesiones (cortes con cuchillo y quemaduras) en relación con el intento de elaboración de platos. Un paciente llegó a ingerir un laxante. Conclusiones: La retirada de zolpidem resolvió de forma inmediata las conductas anormales durante el sueño en todos los casos. Esto subraya la importancia de diagnosticar adecuadamente este efecto secundario. Abstract: Objective: To present five patients with zolpidem-induced sleep-related behavioural disorders. Methods: Evaluation using a questionnaire designed to study sleep behaviours and past medical history in all patients. Results: The patients performed complex actions while sleep-walking (telephoning, house-cleaning, feeding the dog or waxing their legs). Inappropriate feeding behaviour with excessive food intake during the night were reported by all patients. All had weight gain, which in one patient led to extreme obesity. Two patients suffered injuries (knife cuts and burns) related to attempting to prepare food. One patient took a laxative. Conclusion: Withdrawal of zolpidem resolved the behaviours in all cases, highlighting the importance of an adequate diagnosis of this side effect. Palabras clave: Zolpidem, Síndrome de la cena durante el sueño, Síndrome del comer nocturno, Sonambulismo, Sueño, Efecto secundario, Obesidad, Hiperfagia, Amnesia, Keywords: Zolpidem, Sleep-related food disorder, Nocturnal eating syndrome, Sleepwalking, Sleep, Side effect, Obesity, Hyperphagia, Amnesia

Objective: To present five patients with zolpidem-induced sleep-related behavioural disorders. Methods: Evaluation using a questionnaire designed to study sleep behaviours and past medical history in all patients. Results: The patients performed complex actions while sleep-walking (telephoning, house-cleaning, feeding the dog or waxing their legs). Inappropriate feeding behaviour with excessive food intake during the night were reported by all patients. All had weight gain, which in one patient led to extreme obesity. Two patients suffered injuries (knife cuts and burns) related to attempting to prepare food. One patient took a laxative. Conclusion: Withdrawal of zolpidem resolved the behaviours in all cases, highlighting the importance of an adequate diagnosis of this side effect. Resumen: Objetivo: Presentar cinco pacientes con trastornos conductuales durante el sueño, sin conciencia posterior de los mismos, inducidos por zolpidem. Métodos: Evaluación con un cuestionario diseñado para estudiar las características y las conductas realizadas durante el sueño por todos los pacientes. Resultados: Las conductas realizadas por los pacientes fueron muy variadas (telefonear, limpieza y labores del hogar, alimentar al perro o depilarse), aunque en todos los pacientes se recogieron conductas alimentarias inapropiadas. Todos sufrieron una ganancia pon-deral importante, debido a su preferencia por alimentos hipercalóricos durante los episodios, que en una de las pacientes desembocó en una obesidad extrema. Dos de los pacientes sufrieron lesiones (cortes con cuchillo y quemaduras) en relación con el intento de elaboración de platos. Un paciente llegó a ingerir un laxante. Conclusiones: La retirada de zolpidem resolvió de forma inmediata las conductas anormales durante el sueño en todos los casos. Esto subraya la importancia de diagnosticar adecuadamente este efecto secundario. Keywords: Zolpidem, Sleep-related food disorder, Nocturnal eating syndrome, Sleepwalking, Sleep, Side effect, Obesity, Hyperphagia, Amnesia, Palabras clave: Zolpidem, Síndrome de la cena durante el sueño, Síndrome del comer nocturno, Sonambulismo, Sueño, Efecto secundario, Obesidad, Hiperfagia, Amnesia

Narcolepsy type 1 (NT1) is caused by a loss of hypocretin/orexin transmission. Risk factors include pandemic 2009 H1N1 influenza A infection and immunization with Pandemrix®. Here, we dissect disease mechanisms and interactions with environmental triggers in a multi-ethnic sample of 6,073 cases and 84,856 controls. We fine-mapped GWAS signals within HLA (DQ0602, DQB1*03:01 and DPB1*04:02) and discovered seven novel associations (CD207, NAB1, IKZF4-ERBB3, CTSC, DENND1B, SIRPG, PRF1). Significant signals at TRA and DQB1*06:02 loci were found in 245 vaccination-related cases, who also shared polygenic risk. T cell receptor associations in NT1 modulated TRAJ*24, TRAJ*28 and TRBV*4-2 chain-usage. Partitioned heritability and immune cell enrichment analyses found genetic signals to be driven by dendritic and helper T cells. Lastly comorbidity analysis using data from FinnGen, suggests shared effects between NT1 and other autoimmune diseases. NT1 genetic variants shape autoimmunity and response to environmental triggers, including influenza A infection and immunization with Pandemrix®.

Este artículo explora cómo medios de comunicación españoles abordan la ética de las relaciones sexuales e influyen en la construcción y percepción de la sexualidad de la audiencia más joven -denominada generación Z o zoomers- a través de sus redes sociales. Esta observación coincide con el proceso legislativo de la ‘Ley del solo sí es sí’, un cambio normativo de relevancia social y mediática que pone el consentimiento en el punto de mira de las relaciones tras el incremento de agresiones sexuales en grupo de hombres contra una mujer. A través de una metodología cualitativa, basada en análisis del contenido y el discurso, se exploran 13585 contenidos publicados por 13 medios de comunicación en Instagram y TikTok. Los resultados evidencian que la cobertura mediática se ciñe a polémicas políticas y temporales, sin pretensión de profundizar y contextualizar en los diferentes aspectos que envuelven las relaciones sexuales y el consentimiento. Se concluye que, a pesar del potencial de las nuevas narrativas audiovisuales de ambas redes sociales para la cobertura informativa e interpretativa, en la actualidad los medios no asumen una función educomunicativa en torno a la sexualidad. Sin embargo, los contenidos de carácter divulgativo e inclusivos por lo que respecta al género, basados en una argumentación razonada, son los que despiertan mayor interés entre las audiencias más jóvenes, manifestado en un mayor número de “me gusta” y visualizaciones.

ObjectiveIn 2022, several cases of ocular hypertension (OHT) related to EyeCee One preloaded IOLs were reported. The aim of this study was to determine the presurgical and surgical variables associated with this response.Methods and analysisAn analysis was conducted on patients who underwent isolated cataract surgery between September 2022 and December 2022 at the Hospital Universitario del Henares. The influence of potential factors was studied using the Kruskal–Wallis test and multiple regression analysis.ResultsA total of 353 cataract surgeries were included in the study. No significant differences between the different IOLs were found related to a change in the IOP on the first postoperative day (p = 0.395), but the change in the IOP after 1 month was higher in the EyeCee One group (p = 0.016). Approximately 6.1% of the patients who received EyeCee One had an IOP increase greater than 10 mmHg, compared to only 0.8% of the patients who received other IOLs. The odds ratio (OR) of experiencing an IOP increase greater than 10 mmHg in the EyeCee One group at the 1-month visit was 7.99 (1.52–41.99). The multiple regression analysis showed that receiving the EyeCee One lens was associated with a 2-mmHg increase in IOP. A previous history of glaucoma or OHT was not associated with greater IOP. Two patients in the EyeCee One group developed severe visual loss.ConclusionPatients who received the EyeCee One IOL experienced significant increases in IOP at the 1-month visit. A small number of patients might suffer visual loss secondary to the rise in IOP.