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9,932 results on '"A. Haverich"'

1. Decellularized homograft for aortic valve replacement two years after lung transplantation

Author

P. Iablonskii, F. Ius, I. Tudorache, A. Martens, S. Sarikouch, J. Salman, A. Haverich, and S. Cebotari

Subjects
decellularized homograft, cardiac surgery after lung transplantation, Surgery, RD1-811
Abstract

Cardiac valvular surgery in patients after lung transplantation is a challenging procedure, reports are scarce. We report a 29-year-old patient who underwent concomitant mitral valve reconstruction and implantation of a decellularized aortic homograft two years after bilateral lung transplantation.

Published
2022
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2. Preoperative serum uric acid predicts incident acute kidney injury following cardiac surgery

Author

T. Kaufeld, K. A. Foerster, T. Schilling, J. T. Kielstein, J. Kaufeld, M. Shrestha, H. G. Haller, A. Haverich, and B. M. W. Schmidt

Subjects
Renal impairment, Cardiac surgery, Serum uric acid, Kidney injury, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Abstract Background Acute kidney injury (AKI) following cardiac surgery is a frequent complication and several risk factors increasing its incidence have already been characterized. This study evaluates the influence of preoperative increased serum uric acid (SUA) levels in comparison with other known risk factors on the incidence of AKI following cardiac surgery. Methods During a period of 5 month, 247 patients underwent elective coronary artery bypass grafting, valve replacement/ repair or combined bypass and valve surgery. Datas were prospectively analyzed. Primary endpoint was the incidence of AKI as defined by the AKI criteria comparing patients with preoperative serum uric acid (SUA) levels below versus above the median. Multivariate logistic regression analysis was used to identify independent predictors of postoperative AKI. Results Thirty (12.1%) of the 247 patients developed postoperative AKI, 24 of 30 (80%) had preoperative SUA- levels above the median (≥373 μmol/l) (OR: 4.680, CI 95% 1.840; 11.904, p = 0.001). In the multivariate analysis SUA levels above the median (OR: 5.497, CI 95% 1.772; 17.054, p = 0.003), cardiopulmonary bypass (CPB) time > 90 min (OR: 4.595, CI 95% 1.587; 13.305, p = 0.005), cardiopulmonary bypass (CPB) > 30 kg/m2 (OR: 3.208, CI 95% 1.202; 8.562; p = 0.02), and preoperative elevated serum-creatinine levels (OR: 1.015, CI 95% 1.001; 1.029, p = 0.04) were independently associated with postoperative AKI. Conclusions Serum uric acid is an independent risk marker for AKI after cardiac surgery. From all evaluated factors it showed the highest odds ratio.

Published
2018
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4. TISSUE ENGINEERING OF THE ATRIOVENTRICULAR VALVE: DECELLULARIZED MATRIX IN OVINE MITRAL ALLOGRAFT MODEL

Author

P. P. Iablonskii, S. Cebotari, I. Tudorache, A. Hilfiker, S. M. Yashin, and A. Haverich

Subjects
tissue engineering, mitral valve, Surgery, RD1-811
Abstract

Aim. Development of the tissue engineered matrix for the atrioventricular valve graft in a large animal model. Materials and мethods. The study was performed on ovine mitral valves (n = 100). The decellularization of the whole mitral valve grafts was performed using 21 different detergent-based protocols. The effectiveness of the decellularization was investigated by immunofluorescent staining for DNA (as a marker of intracellular antigens) and α-GAL (as a marker of membrane-associated antigens), as well as DNA quantification. The mechanical properties and the repopulation potential were analyzed. The structure and repopulation rate analysis included hematoxylin-eosin, Movat’s pentachrome and Van Gieson histological staining, and immunofluorescent staining for collagen I and IV, as well as endothelial cell markers. Results. The protocols that included the gradual rise of the detergent solution were shown to be the most effective for the decellularization of the whole mitral valve graft. At the same time, the detergents alone failed to remove α-GAL. The reducing agent enhanced the decellularization, which resulted in complete removal of DNA and α-GAL, according to immunofluorescent staining. DNA quantification showed a 96.4% reduction in DNA content. The mechanical properties were shown to be comparable to the native tissue. The reseeding of the decellularized tissue showed a potential for the repopulation. Conclusions. A new matrix for the atrioventricular valve substitute could be developed using the decellularization as the initial step of the valve tissue engineering. The detergent combined with a reducing agent showed significantly better results compared to the detergents alone for the mitral valve decellulrization. The matrix demonstrated mechanical properties, comparable with the native one, and the potential for the repopulation.

Published
2015
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5. Matched comparison of decellularized homografts and bovine jugular vein conduits for pulmonary valve replacement in congenital heart disease

Author

Bobylev, Dmitry, Horke, Alexander, Avsar, Murat, Cvitkovic, Tomislav, Boethig, Dietmar, Hazekamp, Mark, Meyns, Bart, Rega, Filip, Dave, Hitendu, Schmiady, Martin, Ciubotaru, Anatol, Cheptanaru, Eduard, Vida, Vladimiro, Padalino, Massimo, Tsang, Victor, Jashari, Ramadan, Laufer, Günther, Andreas, Martin, Andreeva, Alexandra, Tudorache, Igor, Cebotari, Serghei, Haverich, Axel, and Sarikouch, Samir

Published
2024
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14. Einführung

Author

Haverich, Axel, Boyle, Erin Colleen, Haverich, Axel, and Boyle, Erin Colleen

Published
2023
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21. Inflammation and vascular remodeling in COVID-19 hearts

Author

Werlein, Christopher, Ackermann, Maximilian, Stark, Helge, Shah, Harshit R., Tzankov, Alexandar, Haslbauer, Jasmin Dinonne, von Stillfried, Saskia, Bülow, Roman David, El-Armouche, Ali, Kuenzel, Stephan, Robertus, Jan Lukas, Reichardt, Marius, Haverich, Axel, Höfer, Anne, Neubert, Lavinia, Plucinski, Edith, Braubach, Peter, Verleden, Stijn, Salditt, Tim, Marx, Nikolaus, Welte, Tobias, Bauersachs, Johann, Kreipe, Hans-Heinrich, Mentzer, Steven J., Boor, Peter, Black, Stephen M., Länger, Florian, Kuehnel, Mark, and Jonigk, Danny

Published
2023
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26. Lung transplantation despite preformed donor-specific antihuman leukocyte antigen antibodies: a 9-year single-center experience

Author

Heise, Emma L., Chichelnitskiy, Evgeny, Greer, Mark, Franz, Maximilian, Aburahma, Khalil, Iablonskii, Pavel, de Manna, Nunzio D., Christoph, Stella, Verboom, Murielle, Hallensleben, Michael, Boethig, Dietmar, Avsar, Murat, Welte, Tobias, Schwerk, Nicolaus, Sommer, Wiebke, Haverich, Axel, Warnecke, Gregor, Kuehn, Christian, Falk, Christine, Salman, Jawad, and Ius, Fabio

Published
2023
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28. List of contributors: volume I

Author

Adademir, Taylan, primary, Altaş, Özge, additional, Anastasiadis, Kyriakos, additional, Antonitsis, Polychronis, additional, Argiriadou, Helena, additional, Athanasiou, Thanos, additional, Avgerinos, Dimitrios V., additional, Bannon, Paul G., additional, Bates, Michael J., additional, Baysal, Pınar Karaca, additional, Baş, Tolga, additional, Benk, Christoph, additional, Bernabei, Annalisa, additional, Bertolin, Stephanie, additional, Bouchez, Stefaan, additional, Boyd, Walter Doug, additional, Can, Mehmet, additional, Çankaya, Nuray, additional, Carrel, Thierry, additional, Çekmecelioğlu, Davut, additional, Chitwood, W. Randolph, additional, Cibin, Giorgia, additional, Clark, Stephen, additional, Cooper, John R., additional, Coselli, Joseph S., additional, Dan, Yongwook, additional, De Piero, Maria Elena, additional, De Somer, Filip M.J.J., additional, Deliopoulos, Apostolos, additional, Duman, Mustafa, additional, Eke, Uğur, additional, El-Sayed Ahmed, Magdy M., additional, Ersoy, Ercan, additional, Évora, Patricia Martinez, additional, Evora, Paulo Roberto B., additional, Fabozzo, Assunta, additional, Faggian, Giuseppe, additional, Fanning, Jonathon Paul, additional, Fergadi, Maria, additional, Fisher, David, additional, Fitzgerald, David, additional, Francica, Alessandra, additional, Frazier, O. Howard, additional, Galdieri, Nicola, additional, Gerosa, Gino, additional, Giuliani, Gabriel, additional, Gordon, Katherine L., additional, Güney, Pınar Atagün, additional, Gürcü, Mustafa Emre, additional, Gygax, Erich, additional, Hançer, Hakan, additional, Harky, Amer, additional, Haverich, Axel, additional, Holcomb, Ryan M., additional, Hon, Kay, additional, Ibáñez, Cristina, additional, Jacob, Cecilio, additional, Kalangos, Afksendiyos, additional, Kibler, Kathleen, additional, Kritharides, Leonard, additional, Krupnick, Alexander S., additional, Kılıç, Şefika, additional, Kırali, Kaan, additional, Kızmaz, Yeşim Uygun, additional, Landoni, Giovanni, additional, Lang, Peter, additional, Leibowitz, Joshua L., additional, Linardi, Daniele, additional, Lomivorotov, Vladimir, additional, Lomivorotova, Ludmila, additional, Longnus, Sarah Henning, additional, Luciani, Giovanni Battista, additional, Magouliotis, Dimitrios, additional, Maier, Sven, additional, Maj, Giulia, additional, Mariani, Silvia, additional, Melamed, Naomi, additional, Molina-Andujar, Alícia, additional, Murkin, John M., additional, Myers, Gerard J., additional, Mylonas, Konstantinos S., additional, Myneni, Manoj, additional, Nifong, L. Wiley, additional, Onorati, Francesco, additional, Orozco-Sevilla, Vicente, additional, Özer, Tanıl, additional, Özgür, Mustafa Mert, additional, Oğuzhan, Özlem, additional, Oğuş, Halide, additional, Pappalardo, Federico, additional, Patel, Krishna, additional, Pathania, Vikrant, additional, Patlolla, Sri Harsha, additional, Perdomo, Juan, additional, Pisano, Antonio, additional, Poch, Esteban, additional, Polat, Erdal, additional, Prempeh, Agya B.A., additional, Puskas, John D., additional, Quintana, Eduard, additional, Raja, Shahzad G., additional, Rajagopal, Keshava, additional, Ramponi, Fabio, additional, Resley, Justin, additional, Romero García, Carolina Soledad, additional, Rungatscher, Alessio, additional, Sareyyüpoğlu, Başar, additional, Schaff, Hartzell V., additional, Seco, Michael, additional, Shah, Aakash, additional, Shatelen, Nataliia, additional, Stiljan, Hoxha, additional, Sun, Zhonghua, additional, Swol, Justyna, additional, Şimşek, Mine, additional, Tessari, Chiara, additional, Thomas, Mathew, additional, Tropea, Ilaria, additional, Tsui, Steven, additional, Turina, Marko, additional, Ündar, Akif, additional, Vallely, Michael P., additional, Vandewiele, Korneel, additional, Vokshi, Ismail, additional, Wei, Claudia Yu Yao, additional, Wieselthaler, Georg Maximilian, additional, Wright, Kelly, additional, Yük, Hülya, additional, and Zamvar, Vipin, additional

Published
2023
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31. Outcomes in patients with cardiac amyloidosis undergoing heart transplantation: the eurotransplant experience

Author

Kraus, Martin J., Smits, Jacqueline M., Meyer, Anna L., Strelniece, Agita, van Kins, Arne, Boeken, Udo, Reinecke, Alexander, Provaznik, Zdenek, Van Caenegem, Oliver, Ancion, Arnaud, Berchtold-Herz, Michael, Van Cleemput, Johan J.A., Haverich, Axel, Laufer, Guenther, Gummert, Jan, Karck, Matthias, Warnecke, Gregor, Raake, Philip W., Frey, Norbert, and Kreusser, Michael M.

Published
2023
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33. In-hospital and 6-month outcomes in patients with COVID-19 supported with extracorporeal membrane oxygenation (EuroECMO-COVID): a multicentre, prospective observational study

Author

Lorusso, Roberto, De Piero, Maria Elena, Mariani, Silvia, Di Mauro, Michele, Folliguet, Thierry, Taccone, Fabio Silvio, Camporota, Luigi, Swol, Justyna, Wiedemann, Dominik, Belliato, Mirko, Broman, Lars Mikael, Vuylsteke, Alain, Kassif, Yigal, Scandroglio, Anna Mara, Fanelli, Vito, Gaudard, Philippe, Ledot, Stephane, Barker, Julian, Boeken, Udo, Maier, Sven, Kersten, Alexander, Meyns, Bart, Pozzi, Matteo, Pedersen, Finn M, Schellongowski, Peter, Kirali, Kaan, Barrett, Nicholas, Riera, Jordi, Mueller, Thomas, Belohlavek, Jan, Lo Coco, Valeria, Van der Horst, Iwan C C, Van Bussel, Bas C T, Schnabel, Ronny M, Delnoij, Thijs, Bolotin, Gil, Lorini, Luca, Schmiady, Martin O, Schibilsky, David, Kowalewski, Mariusz, Pinto, Luis F, Silva, Pedro E, Kornilov, Igor, Blandino Ortiz, Aaron, Vercaemst, Leen, Finney, Simon, Roeleveld, Peter P, Di Nardo, Matteo, Hennig, Felix, Antonini, Marta Velia, Davidson, Mark, Jones, Tim J, Staudinger, Thomas, Mair, Peter, Kilo, Juliane, Krapf, Christoph, Erbert, Kathrin, Peer, Andreas, Bonaros, Nikolaos, Kotheletner, Florian, Krenner Mag, Niklas, Shestakova, Liana, Hermans, Greet, Dauwe, Dieter, Meersseman, Philippe, Stockman, Bernard, Nobile, Leda, Lhereux, Olivier, Nrasseurs, Alexandre, Creuter, Jacques, De Backer, Daniel, Giglioli, Simone, Michiels, Gregoire, Foulon, Pierre, Raes, Matthias, Rodrigus, Inez, Allegaert, Matthias, Jorens, Philippe, Debeucklare, Gerd, Piagnerelli, Michael, Biston, Patrick, Peperstraete, Harlinde, Vandewiele, Komeel, Germay, Olivier, Vandeweghe, Dimitri, Havrin, Sven, Bourgeois, Marc, Lagny, Marc-Gilbert, Alois, Genette, Lavios, Nathalie, Misset, Benoit, Courcelle, Romain, Timmermans, Philippe J, Yilmaz, Alaaddin, Vantomout, Michiel, Lehaen, Jerone, Jassen, Ame, Guterman, Herbert, Strauven, Maarten, Lormans, Piet, Verhamme, Bruno, Vandewaeter, catherine, Bonte, Frederik, Vionne, Dominique, Balik, Martin, Blàha, Jan, Lips, Michal, Othal, Michal, Bursa, Filip, Spacek, Radim, Christensen, Steffen, Jorgensen, Vibeke, Sorensen, Marc, Madsen, Soren A, Puss, Severin, Beljantsev, Aleksandr, Saiydoun, gabriel, Fiore, Antonio, Colson, Pascal, Bazalgette, Florian, Capdevila, Xavier, Kollen, Sebastien, Muller, Laurent, Obadia, Jean-Francois, Dubien, Pierre-Yves, Ajrhourh, Lucrezia, Guinot, Pierre G, Zarka, Jonathan, Besserve, Patricia, Malfertheiner, Maximilian V, Dreier, Esther, Heinze, Birgit, Akhyari, Payam, Lichtenberg, Artur, Aubin, Hug, Assman, Alexander, Saeed, Diyar, Thiele, Holger, Baumgaertel, Matthias, Schmitto, Jan D, Ruslan, Natanov, Haverich, Axel, Thielmann, Matthias, Brenner, Thorsten, Ruhpawar, Arjang, Benk, Christoph, Czerny, Martin, Staudacher, Dawid L, Beyersdorf, Fridhelm, Kalbhenn, Johannes, Henn, Philipp, Popov, Aron-Frederik, Iuliu, Torje, Muellenbach, Ralf, Reyher, Christian, Rolfes, Caroline, Lotz, Gosta, Sonntagbauer, Michael, Winkels, Helen, Fichte, Julia, Stohr, Robert, Kalverkamp, Sebastian, Karagiannidis, Christian, Schafer, Simone, Svetlitchny, Alexei, Hopf, Hans-Bernd, Jarczak, Dominik, Groesdonk, Heinirich, Rommer, Magdalena, Hirsch, Jan, Kaehny, Christian, Soufleris, Dimitros, Gavriilidis, Georgios, Pontikis, Kostantinos, Kyriakopoulou, Magdalini, Kyriakoudi, Anna, O'Brien, Serena, Conrick-Martin, Ian, Carton, Edmund, Makhoul, Maged, Ben-Ari, Josef, Hadash, Amir, Kogan, Alexander, Kassif Lerner, Reut, Abu-Shakra, Anas, Matan, Moshe, Balawona, Ahmad, Kachel, Erez, Altshuler, Roman, Galante, Ori, Fuchs, Lior, Almog, Yaniv, Ishay, Yaron S, Lichter, Yael, Gal-oz, Amir, Carmi, Uri, Nini, Asaph, Soroksky, Arie, Dekel, Hagi, Rozman, Ziv, Tayem, Emad, Ilgiyaev, Eduard, Hochman, Yuval, Miltau, daniel, Rapoport, Avigal, Eden, Arieh, Kompanietz, Dmitry, Yousif, Michael, Golos, Miri, Grazioli, Lorenzo, Ghitti, Davide, Loforte, Antonio, Di Luca, Daniela, Baiocchi, Massimo, Pacini, Davide, Cappai, Antioco, Meani, Paolo, Mondino, Michele, Russo, Claudio F, Ranucci, Marco, Fina, Dario, Cotza, Marco, Ballotta, Andrea, Landoni, Giovanni, Nardelli, Pasquale, Fominski, Eygeny V, Brazzi, Luca, Montrucchio, Giorgia, Sales, Gabriele, Simonetti, Umberto, Livigni, Sergio, Silengo, Daniela, Arena, Giulia, Sovatzis, Stefania S, Degani, Antonella, Riccardi, Mariachiara, Milanesi, Elisa, Raffa, Giuseppe, Martucci, Gennaro, Arcadipane, Antonio, Panarello, Giovanna, Chiarini, Giovanni, Cattaneo, Sergio, Puglia, Carmine, Benussi, Stefano, Foti, Giuseppe, Giani, Marco, Bombino, Michela, Costa, Maria Cristina, Rona, Roberto, Avalli, Leonello, Donati, Abele, Carozza, Roberto, Gasparri, Francesco, Carsetti, Andrea, Picichè, Marco, Marinello, Anna, Danzi, Vinicio, Zanin, Anita, Condello, Ignazio, Fiore, Flavio, Moscarelli, Marco, Nasso, Giuseppe, Speziale, Giuseppe, Sandrelli, Luca, Montalto, Andrea, Musumeci, Francesco, Circelli, Alessandro, Russo, Emanuele, Agnoletti, Vanni, Rociola, Ruggero, Milano, Aldo D, Pilato, Emanuele, Comentale, Giuseppe, Montisci, Andrea, Alessandri, Francesco, Tosi, Antonella, Pugliese, Francesco, Giordano, Giovanni, Carelli, Simone, Grieco, Domenico L, Dell'Anna, Antonio M, Antonelli, Massimo, Ramoni, Enrico, Zulueta, Josè, Del Giglio, Mauro, Petracca, Sebastiano, Bertini, Pietro, Guarracino, Fabio, De Simone, Luigi, Angeletti, Paolo M, Forfori, Francesco, Taraschi, Francesco, Quintiliani, Veronica N, Samalavicius, Robertas, Jankuviene, Agne, Scupakova, Nadezda, Urbonas, Karolis, Kapturauskas, Juozas, Soerensen, Gro, Suwalski, Piotr, Linhares Santos, Luis, Marques, Ana, Miranda, Marisa, Teixeira, Sonia, Salgueiro, Andrea, Pereira, Filipe, Ketskalo, Michail, Tsarenko, Sergey, Shilova, Alexandra, Afukov, Ivan, Popugaev, Konstantin, Minin, Sergei, Shelukhin, Daniil, Malceva, Olga, Gleb, Moroz, Skopets, Alexander, Kornelyuk, Roman, Kulikov, Alexandr, Okhrimchuk, Vadim, Turchaninov, Alexandr, Petrushin, Maxim, Sheck, Anastasia, Mekulov, Akhmed, Ciryateva, Svetlana, Urusov, Dmitry, Gorjup, Vojka, Golicnik, Alenka, Goslar, Tomaz, Ferrer, Ricard, Martinez-Martinez, Maria, Argudo, Eduard, Palmer, Neiser, De Pablo Sanchez, Raul, Juan Higuera, Lucas, Arnau Blasco, Lucas, Marquez, Josè A, Sbraga, Fabrizio, Fuset, Mari Paz, De Gopegui, Pablo Ruiz, Claraco, Luis M, De Ayala, Josè A, Peiro, Maranta, Ricart, Pilar, Martinez, Sergio, Chavez, Fernando, Fabra, Marc, Sandoval, elena, Toapanta, David, Carraminana, Albert, Tellez, Adrian, Ososio, Jeysson, Milan, Pablo, Rodriguez, Jorge, Andoni, Garcia, Gutierrez, Carola, Perez de la Sota, Enrique, Eixeres-Esteve, Andrea, Garcia-Maellas, Maria Teresa, Gutierrez-Gutierrez, Judit, Arboleda-Salazar, Rafael, Santa Teresa, Patricia, Jaspe, Alexis, Garrido, Alberto, Castaneda, Galo, Alcantara, Sara, Martinez, Nuria, Perez, Marina, Villanueva, Hector, Vidal Gonzalez, Anxela, Paez, Juan, Santon, Arnoldo, Perez, Cesar, Lopez, Marta, Rubio Lopez, Maria Isabel, Gordillo, Antonio, Naranjo-Izurieta, Jose, Munoz, Javier, Alcalde, Immaculada, Onieva, Fernando, Gimeno Costa, Ricardo, Perez, Francisco, Madrid, Isabel, Gordon, Monica, Albacete Moreno, Carlos L, Perez, Daniel, Lopez, Nayara, Martinenz, Domingo, Blanco-Schweizer, Pablo, Diez, Cristina, Perez, David, Prieto, Ana, Renedo, Gloria, Bustamante, Elena, Cicuendez, Ramon, Citores, Rafael, Boado, Victoria, Garcia, Katherine, Voces, Roberto, Domezain, Monica, Nunez Martinez, Jose Maria, Vicente, Raimundo, Martin, David, Andreu, Antonio, Gomez Casal, Vanesa, Chico, Ignacio, Menor, Eva Maria, Vara, Sabela, Gamacho, Jose, Perez-Chomon, Helen, Javier Gonzales, Francisco, Barrero, Irene, Martin-Villen, Luis, Fernandez, Esperanza, Mendoza, Maria, Navarro, Joaquin, Colomina Climent, Joaquin, Gonzales-Perez, Alfredo, Muniz-Albaceita, Guillermo, Amado, Laura, Rodriguez, Raquel, Ruiz, Emilio, Eiras, Maria, Grins, Edgars, Magnus, Rosen, Kanetoft, Mikael, Eidevald, Marcus, Watson, Pia, Vogt, Paul R, Steiger, Peter, Aigner, Tobias, Weber, Alberto, Grunefelder, Jurg, Kunz, Martin, Grapow, Martin, Aymard, Thierry, Reser, Diana, Agus, Gianluca, Consiglio, Jolanda, Haenggi, Matthias, Hansjoerg, Jenni, Iten, Manuela, Doeble, Thomas, Zenklusen, Urs, Bechtold, Xavier, Faedda, Giovanni, Iafrate, Manuel, Rohjer, Amanda, Bergamaschi, Layla, Maessen, Jos, Reis Miranda, Dinis, Endeman, H, Gommers, D, Meuwese, C, Maas, Jacinta, Van Gijlswijk, MJ, Van Berg, RN, Candura, Dario, Van der Linden, Marcel, Kant, Merijin, Van der Heijden, JJ, Scholten, Eric, Van Belle-van Haren, Nicole, Lagrand, WK, Vlaar, Alexander P, De Jong, Syste, Cander, Basar, Sargin, Murat, Ugur, Murat, Kaygin, Mehmet A, Daly, Kathleen, Agnew, Nicola, Head, Laura, Kelly, Laura, Anoma, Gunawardena, Russell, Clare, Aquino, Verna, Scott, Ian, Flemming, Lucy, Gillon, Stuart, Moore, Olivia, Gelandt, Elton, Auzinger, George, Patel, Sameer, and Loveridge, Robert

Published
2023
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38. Midterm outcomes with a sutureless aortic bioprosthesis in a prospective multicenter cohort study

Author

Zannis, Kostantinos, Pfeiffer, Steffen, Santarpino, Giuseppe, Shrestha, Malakh, Sarikouch, Samir, Gummert, Jan F., Mohr, Friedrich W., Dohmen, Pascal, Stalder, Mario, Roost, Eva, Filipiak, Krzysztof, Niklewski, Tomasz, Madonna, Francesco, Roques, Xavier, Flameng, Willem J., Laczkovics, Axel M.M., Bechtel, Matthias, Prat, Alain G., Banfi, Carlo, Dapunt, Otto E., Eichstaedt, Harald C., Harringer, Wolfgang, Carstens-Fitz, Ulrike, Spyt, Tom J., Wimmer-Greinecker, Jan Gerhard, Machner, Matthias, Tan, Erwin S.H., Casselman, Filip P.A., Yilmaz, Alaaddin, Sonker, Uday, Bleiziffer, Sabine, Oberwalder, Peter J., Kocher, Alfred A., Seitelberger, Rainald, Treede, Hendrik, Conradi, Leonard, Cocchieri, Riccardo, De Mol, Bas, Roussel, Jean-Christian, Despins, Philippe, Jakob, Heinz G., Wendt, Daniel, Fischlein, Theodor, Meuris, Bart, Folliguet, Thierry, Hakim-Meibodi, Kavous, Misfeld, Martin, Carrel, Thierry, Zembala, Marian, Cerutti, Elisa, Asch, Federico M., and Haverich, Axel

Published
2022
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39. Heart transplantation across preformed donor-specific antibody barriers using a perioperative desensitization protocol

Author

Sommer, Wiebke, Avsar, Murat, Aburahma, Khalil, Salman, Jawad, Kaufeld, Klaus Tim, Rojas, Sebastian V., Meyer, Anna L., Chichelnitskiy, Evgeny, Süsal, Caner, Kreusser, Michael M., Verboom, Murielle, Hallensleben, Michael, Bara, Christoph, Blasczyk, Rainer, Falk, Christine, Karck, Matthias, Haverich, Axel, Ius, Fabio, and Warnecke, Gregor

Published
2022
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40. A Morphomolecular Approach to Alveolar Capillary Dysplasia

Author

Kamp, Jan C., Neubert, Lavinia, Ackermann, Maximilian, Stark, Helge, Plucinski, Edith, Shah, Harshit R., Janciauskiene, Sabina, Bergmann, Anke K., Schmidt, Gunnar, Welte, Tobias, Haverich, Axel, Werlein, Christopher, Braubach, Peter, Laenger, Florian, Schwerk, Nicolaus, Olsson, Karen M., Fuge, Jan, Park, Da-Hee, Schupp, Jonas C., Hoeper, Marius M., Kuehnel, Mark P., and Jonigk, Danny D.

Published
2022
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41. Effectiveness of wearable devices as a support strategy for maintaining physical activity after a structured exercise intervention for employees with metabolic syndrome: a randomized controlled trial

Author

Bayerle, Pauline, Kerling, Arno, Kück, Momme, Rolff, Simone, Boeck, Hedwig Theda, Sundermeier, Thorben, Ensslen, Ralf, Tegtbur, Uwe, Lauenstein, Dirk, Böthig, Dietmar, Bara, Christoph, Hanke, Alexander, Terkamp, Christoph, Haverich, Axel, Stiesch, Meike, de Zwaan, Martina, Haufe, Sven, and Nachbar, Lars

Published
2022
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42. Effectiveness of wearable devices as a support strategy for maintaining physical activity after a structured exercise intervention for employees with metabolic syndrome: a randomized controlled trial

Author

Pauline Bayerle, Arno Kerling, Momme Kück, Simone Rolff, Hedwig Theda Boeck, Thorben Sundermeier, Ralf Ensslen, Uwe Tegtbur, Dirk Lauenstein, Dietmar Böthig, Christoph Bara, Alexander Hanke, Christoph Terkamp, Axel Haverich, Meike Stiesch, Martina de Zwaan, Sven Haufe, and Lars Nachbar

Subjects
Physical activity, Telemonitoring, Wearable device, Metabolic syndrome, Sustainability, Maintenance, Sports medicine, RC1200-1245
Abstract

Abstract Background Metabolic syndrome (MetS) is associated with an increased risk for cardiovascular events and high socioeconomic costs. Despite lifestyle interventions focusing on exercise are effective strategies to improve parameters of the above aspects, many programs fail to show sustained effects in the long-term. Methods At visit 2 (V2) 129 company employees with diagnosed MetS, who previously participated in a 6-month telemonitoring-supported exercise intervention, were randomized into three subgroups for a 6-month maintenance treatment phase. A wearable activity device was provided to subgroup A and B to assess and to track physical activity. Further subgroup A attended personal consultations with individual instructions for exercise activities. Subgroup C received neither technical nor personal support. 6 months later at visit (V3), changes in exercise capacity, MetS severity, work ability, health-related quality of life and anxiety and depression were compared between the subgroups with an analysis of variance with repeated measurements. Results The total physical activity (in MET*h/week) declined between visit 2 and visit 3 (subgroup A: V2: 48.0 ± 33.6, V3: 37.1 ± 23.0; subgroup B: V2: 52.6 ± 35.7, V3: 43.8 ± 40.7, subgroup C: V2: 51.5 ± 29.7, V3: 36.9 ± 22.8, for all p = 0.00) with no between-subgroup differences over time (p = 0.68). In all three subgroups the initial improvements in relative exercise capacity and MetS severity were maintained. Work ability declined significantly in subgroup C (V2: 40.3 ± 5.0, V3: 39.1 ± 5.7; p

Published
2022
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45. Simultaneous Aortic and Pulmonary Valve Replacement in Repaired Congenital Heart Disease.

Author

Bobylev, Dmitry, Hysko, Klea, Avsar, Murat, Cvitkovic, Tomislav, Petena, Elena, Sarikouch, Samir, Bleck, Mechthild Westhoff, Hansmann, Georg, Haverich, Axel, and Horke, Alexander

Subjects
AORTIC valve transplantation, CONGENITAL heart disease, PULMONARY valve, CARDIAC patients, CARDIOPULMONARY bypass
Abstract

Objectives Patients with congenital heart disease frequently require surgical or percutaneous interventional valve replacement after initial congenital heart defect (CHD) repair. In some of these patients, simultaneous replacement of both semilunar valves is necessary, resulting in increased procedural complexity, morbidity, and mortality. In this study, we analyze the outcomes of simultaneous aortic and pulmonary valve replacements following multiple surgical interventions for CHD. Methods This was a retrospective study of 24 patients who after initial repair of CHD underwent single-stage aortic and pulmonary valve replacement at our institution between 2003 and 2021. Results The mean age of the patients was 28 ± 13 years; the mean time since the last surgery was 15 ± 11 years. Decellularized valved homografts (DVHs) were used in nine patients, and mechanical valves were implanted in seven others. In eight patients, DVHs, biological, and mechanical valves were implanted in various combinations. The mean cardiopulmonary bypass time was 303 ± 104 minutes, and aortic cross-clamp time was 152 ± 73 minutes. Two patients died at 12 and 16 days postoperatively. At a maximum follow-up time of 17 years (mean 7 ± 5 years), 95% of the surviving patients were categorized as New York Heart Association heart failure class I. Conclusion Single-stage aortic and pulmonary valve replacement after initial repair of CHD remains challenging with substantial perioperative mortality (8.3%). Nevertheless, long-term survival and clinical status at the latest follow-up were excellent. The valve type had no relevant impact on the postoperative course. The selection of the valves for implantation should take into account operation-specific factors—in particular reoperability—as well as the patients' wishes. [ABSTRACT FROM AUTHOR]

Published
2024
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46. Knockdown of swine leukocyte antigen expression in porcine lung transplants enables graft survival without immunosuppression.

Author

Figueiredo, Constanca, Chen-Wacker, Chen, Salman, Jawad, Carvalho-Oliveira, Marco, Monthé, Thierry Siemeni, Höffler, Klaus, Rother, Tamina, Hacker, Karolin, Valdivia, Emilio, Pogozhykh, Olena, Hammer, Sabine, Sommer, Wiebke, Yuzefovych, Yuliia, Wenzel, Nadine, Haverich, Axel, Warnecke, Gregor, and Blasczyk, Rainer

Subjects
GENE expression, LUNG transplantation, GRAFT survival, MAJOR histocompatibility complex, HISTOCOMPATIBILITY antigens
Abstract

Immune rejection remains the major obstacle to long-term survival of allogeneic lung transplants. The expression of major histocompatibility complex molecules and minor histocompatibility antigens triggers allogeneic immune responses that can lead to allograft rejection. Transplant outcomes therefore depend on long-term immunosuppression, which is associated with severe side effects. To address this problem, we investigated the effect of genetically engineered transplants with permanently down-regulated swine leukocyte antigen (SLA) expression to prevent rejection in a porcine allogeneic lung transplantation (LTx) model. Minipig donor lungs with unmodified SLA expression (control group, n = 7) or with modified SLA expression (treatment group, n = 7) were used to evaluate the effects of SLA knockdown on allograft survival and on the nature and strength of immune responses after terminating an initial 4-week period of immunosuppression after LTx. Genetic engineering to down-regulate SLA expression was achieved during ex vivo lung perfusion by lentiviral transduction of short hairpin RNAs targeting mRNAs encoding β2-microglobulin and class II transactivator. Whereas all grafts in the control group were rejected within 3 months, five of seven animals in the treatment group maintained graft survival without immunosuppression during the 2-year monitoring period. Compared with controls, SLA-silenced lung recipients had lower donor-specific antibodies and proinflammatory cytokine concentrations in the serum. Together, these data demonstrate a survival benefit of SLA–down-regulated lung transplants in the absence of immunosuppression. Editor's summary: Solid organ transplants have saved the lives of many with late-stage organ failure. However, the need to match major histocompatibility complex (MHC) molecules reduces the number of donor-recipient pairs and results in long waits for donor organs. A strategy to avoid the need for MHC matching is to knock down MHC expression in the transplanted organ altogether. Here, Figueiredo et al. transplanted lungs that underwent gene engineering to knock down MHC expression in recipient pigs. This approach, which relied on lentiviral vectors carrying shRNAs against B2M and CIITA, effectively hid the donor lungs from the immune system, enabling long-term graft survival. Together, these results suggest that MHC knockdown may be a feasible strategy to improve graft survival after solid organ transplantation. —Courtney Malo [ABSTRACT FROM AUTHOR]

Published
2024
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49. α1-Antitrypsin attenuates acute rejection of orthotopic murine lung allografts

Author

Tomoyuki Nakagiri, Sabine Wrenger, Kokilavani Sivaraman, Fabio Ius, Tobias Goecke, Patrick Zardo, Veronika Grau, Tobias Welte, Axel Haverich, Ann-Kathrin Knöfel, and Sabina Janciauskiene

Subjects
Lung transplantation, Acute allograft rejection, Mouse orthotopic single lung transplantation model, Primary graft dysfunction, Alpha1-antitrypsin, Diseases of the respiratory system, RC705-779
Abstract

Abstract Background α1-Antitrypsin (AAT) is an acute phase glycoprotein, a multifunctional protein with proteinase inhibitory, anti-inflammatory and cytoprotective properties. Both preclinical and clinical experiences show that the therapy with plasma purified AAT is beneficial for a broad spectrum of inflammatory conditions. The potential effects of AAT therapy have recently been highlighted in lung transplantation (LuTx) as well. Methods We used a murine fully mismatched orthotopic single LuTx model (BALB/CJ as donors and C57BL/6 as recipients). Human AAT preparations (5 mg, n = 10) or vehicle (n = 5) were injected to the recipients subcutaneously prior to and intraperitoneally immediately after the LuTx. No immune suppressive drugs were administered. Three days after the transplantation, the mice were sacrificed, and biological samples were assessed. Results Histological analysis revealed significantly more severe acute rejection in the transplanted lungs of controls than in AAT treated mice (p

Published
2021
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50. Cell colonization potential of thermoplastic silicone-based polyurethane nonwovens for novel heart valve prosthesis

Author

Ratna Tuladhar Sugat, Teske Michael, Oschatz Stefan, Illner Sabine, Schilling Tobias, Schmidt Wolfram, Grabow Niels, Haverich Axel, and Schmitz Klaus-Peter

Subjects
heart valve scaffolds, nonwoven polymers, endothelial progenitor cells, Medicine
Abstract

Heart valve tissue engineering aims at creating living valves through colonization of scaffolds with patient’s own cells. Various cell sources have been explored focusing mainly on endothelialization of the scaffold surface. Endothelial like cells, such as endothelial progenitor cells (EPCs), which can be isolated from peripheral blood or bone marrow could be a suitable option. In this study we investigated cell colonization potential of ovine EPCs (OEPCs) on thermoplastic silicone-based polyurethane (TSPU) polymer scaffolds. TSPU nonwovens with and without vascular endothelial growth factor (VEGF) functionalization were used. SEM images showed that by day 3 the cells were growing as patches on the surface of both polymer groups. The cell patches continued growing and started covering more of the nonwoven surface. On day 7 the cells had almost covered the scaffold surface. The cells were more uniformly distributed as monolayer on the functionalized TSPU compared to the non-functionalized nonwovens. Live/Dead staining provided bright green fluorescence on the samples, indicating metabolically active alive cells. These static cell seeding experiments demonstrated that functionalized TPSU nonwovens support endothelialization. The feasibility of TPSU nonwovens as heart valve prosthesis scaffold could be further explored with animal studies in an ovine model.

Published
2021
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