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1. Effect of bariatric surgery on HDL-mediated cholesterol efflux capacity

Author

O. Castañer, K. A. Pérez-Vega, S. Álvarez, S. Vázquez, A. Casajoana, G. Blanchart, S. Gaixas, H. Schröder, M. D. Zomeño, I. Subirana, D. Muñoz-Aguayo, M. Fitó, D. Benaiges, A. Goday, and A. Oliveras

Subjects
cholesterol efflux capacity, obesity, weight loss, HDLc, lipid profile, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

BackgroundBariatric surgery (BS) is the most effective intervention for severe obesity, leading to sustained weight loss, reduced obesity-related comorbidities, and cardiovascular mortality.AimTo assess changes in high-density lipoprotein (HDL) functions [cholesterol efflux capacity (CEC) and anti-inflammatory capacity] at different follow-up times in patients with severe obesity undergoing BS.MethodsA prospective observational study within a cohort of consecutively enrolled patients with severe obesity scheduled to undergo BS. In total, 62 participants (77% women), with a mean age of 42.1 years (SD 9.33 years) underwent BS. Regarding the surgical procedure, 27 (43.5%) underwent sleeve gastrectomy and 35 (56.5%) Roux-en-Y gastric bypass. All patients were evaluated preoperatively and at 1, 3, 6, and 12 months after surgery.ResultsA decrease in body mass index and an improvement in the systemic lipid profile, indicated by reductions in total cholesterol, low-density lipoprotein cholesterol (LDLc), and remnant cholesterol, and an increase in HDL cholesterol (HDLc) was observed (all p trend

Published
2024
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2. Fatty liver index as a predictor for type 2 diabetes in subjects with normoglycemia in a nationwide cohort study

Author

E. García-Escobar, S. Valdés, F. Soriguer, J. Vendrell, I. M. Urrutia-Etxebarria, C. Maldonado-Araque, E. Ortega, P. Ocón, E. Montanya, E. Menéndez, A. Lago-Sampedro, T. González-Frutos, R. Gomis, A. Goday, S. García-Serrano, J. L. Galán-García, C. Castell, E. Bordiú, R. Badía, G. Aguilera-Venegas, J. Girbés, S. Gaztambide, E. Delgado, F. J. Chaves, L. Castaño, A. Calle-Pascual, G. Rojo-Martínez, and J. Franch-Nadal

Subjects
Medicine, Science
Abstract

Abstract Our aim was to evaluate whether fatty liver index (FLI) is associated with the risk of type 2 diabetes (T2DM) development within the Spanish adult population and according to their prediabetes status; additionally, to examine its incremental predictive value regarding traditional risk factors. A total of 2260 subjects (Prediabetes: 641 subjects, normoglycemia: 1619 subjects) from the Di@bet.es cohort study were studied. Socio-demographic, anthropometric, clinical data and survey on habits were recorded. An oral glucose tolerance test was performed and fasting determinations of glucose, lipids and insulin were made. FLI was calculated and classified into three categories: Low ( 60). In total, 143 people developed diabetes at follow-up. The presence of a high FLI category was in all cases a significant independent risk factor for the development of diabetes. The inclusion of FLI categories in prediction models based on different conventional T2DM risk factors significantly increase the prediction power of the models when all the population was considered. According to our results, FLI might be considered an early indicator of T2DM development even under normoglycemic condition. The data also suggest that FLI could provide additional information for the prediction of T2DM in models based on conventional risk factors.

Published
2021
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4. Relationship between sex, APOE genotype, endocannabinoids and cognitive change in older adults with metabolic syndrome during a 3-year Mediterranean diet intervention

Author

Soldevila-Domenech, Natalia, Fagundo, Beatriz, Cuenca-Royo, Aida, Forcano, Laura, Gomis-González, Maria, Boronat, Anna, Pastor, Antoni, Castañer, Olga, Zomeño, Maria Dolores, Goday, Albert, Dierssen, Mara, Baghizadeh Hosseini, Khashayar, Ros, Emilio, Corella, Dolores, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Fernández-Aranda, Fernando, Fitó, Montserrat, and de la Torre, Rafael

Published
2024
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8. Intensive Weight-Loss Lifestyle Intervention Using Mediterranean Diet and COVID-19 Risk in Older Adults: Secondary Analysis of PREDIMED-Plus Trial

Author

Shyam, Sangeetha, García-Gavilán, J. F., Paz-Graniel, I., Gaforio, J. J., Martínez-González, M. Á., Corella, D., Martínez, J. A., Alonso-Gómez, Á. M., Wärnberg, J., Vioque, J., Romaguera, D., López-Miranda, J., Estruch, R., Tinahones, F. J., Lapetra, J., Serra-Majem, J. L., Bueno-Cavanillas, A., Tur, J. A., Sánchez, V. Martín, Pintó, X., Matía-Martín, P., Vidal, J., del Mar Alcarria, M., Daimiel, L., Ros, E., Fernandez-Aranda, F., Nishi, S. K., García-Regata, Ó., Araluce, R. Perez, Asensio, E. M., Castañer, O., Garcia-Rios, A., Oncina-Cánovas, A., Bouzas, C., Zulet, M. A., Rayó, E., Casas, R., Martin-Pelaez, S., Tojal-Sierra, L., Bernal-López, M. R., Carlos, S., Sorlí, J. V., Goday, A., Peña-Orihuela, P. J., Pastor-Morel, A., Eguaras, S., Zomeño, M. D., Delgado-Rodríguez, M., Babio, N., Fitó, M., and Salas-Salvadó, Jordi

Published
2023
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10. Evaluation of Health-Related Quality of Life according to Carbohydrate Metabolism Status: A Spanish Population-Based Study (Di@bet.es Study)

Author

C. Marcuello, A. L. Calle-Pascual, M. Fuentes, I. Runkle, F. Soriguer, A. Goday, A. Bosch-Comas, E. Bordiú, R. Carmena, R. Casamitjana, L. Castaño, C. Castell, M. Catalá, E. Delgado, J. Franch, S. Gaztambide, J. Girbés, R. Gomis, G. Gutiérrez, A. López-Alba, M. T. Martínez-Larrad, E. Menéndez, I. Mora-Peces, E. Ortega, G. Pascual-Manich, G. Rojo-Martínez, M. Serrano-Rios, S. Valdés, J. A. Vázquez, and J. Vendrell

Subjects
Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Objective. To evaluate the association between diabetes mellitus and health-related quality of life (HRQOL) controlled for several sociodemographic and anthropometric variables, in a representative sample of the Spanish population. Methods. A population-based, cross-sectional, and cluster sampling study, with the entire Spanish population as the target population. Five thousand and forty-seven participants (2162/2885 men/women) answered the HRQOL short form 12-questionnaire (SF-12). The physical (PCS-12) and the mental component summary (MCS-12) scores were assessed. Subjects were divided into four groups according to carbohydrate metabolism status: normal, prediabetes, unknown diabetes (UNKDM), and known diabetes (KDM). Logistic regression analyses were conducted. Results. Mean PCS-12/MCS-12 values were 50.9±8.5/ 47.6±10.2, respectively. Men had higher scores than women in both PCS-12 (51.8±7.2 versus 50.3±9.2; P

Published
2012
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11. Evaluation and Management of Reduced Dietary Diversity in Children with Pediatric Feeding Disorder

Author

Van Hoorn, Megan, Feuling, Mary Beth, Allen, Kim, Berry, Rashelle, Brown, Shonda, Sullivan, Christine M., and Goday, Praveen S.

Abstract

Pediatric Feeding Disorder, a common problem in children, is commoner in children with various developmental disorders. Children with pediatric feeding disorder can have food selectivity and lack dietary diversity (DD). In this paper, an understanding of DD in these children is provided along with a dietary diversity index that can be helpful in measuring and understanding the risks posed by this lack of DD. An overview of a management strategy to address decreased DD is proposed. In these children, improving DD can improve growth, micronutrient status, long-term metabolic health, and potentially quality of life.

Published
2023
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12. Long-term association between water intake and kidney function in a population at high cardiovascular risk

Author

Paz-Graniel, Indira, Valle-Hita, Cristina, Babio, Nancy, Serra-Majem, Lluís, Vioque, Jesus, Zomeño, María Dolores, Corella, Dolores, Pintó, Xavier, Cano-Ibáñez, Naomi, Tur, Josep A., Cuadrado-Soto, Esther, Martínez, J.A., Díaz-López, Andrés, Torres-Collado, Laura, Goday, Albert, Fernández-Carrión, Rebeca, Nissenshon, Mariela, Riera-Mestre, Antoni, Garrido-Garrido, Eva, Bouzas, Cristina, Abete, Itziar, Daimiel, Lidia, Cornejo-Pareja, Isabel, Vázquez-Ruiz, Zenaida, Khoury, Nadine, Pérez-Vega, Karla Alejandra, and Salas-Salvadó, Jordi

Published
2024
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13. Dietary intake of Perfluorooctanesulfonic acid (PFOS) and glucose homeostasis parameters in a non-diabetic senior population

Author

Khoury, Nadine, Ángeles Martínez, María, Nishi, Stephanie K., Ángel Martínez-González, Miguel, Corella, Dolores, Castañer, Olga, Alfredo Martínez, J., Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J, Manuel Santos-Lozano, José, Serra-Majem, Lluís, Bueno-Cavanillas, Aurora, Tur, Josep A., Cinza Sanjurjo, Sergio, Pintó, Xavier, Juan Gaforio, José, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Sayon-Orea, Carmen, V Sorli, Jose, Pérez-Vega, Karla-Alejandra, Garcia-Rios, Antonio, Ortiz-Díaz, Francisco, Gómez-Gracia, Enrique, Zulet, MA, Chaplin, Alice, Casas, Rosa, Salcedo-Bellido, Inmaculada, Tojal-Sierra, Lucas, Bernal-Lopez, Maria-Rosa, Vazquez-Ruiz, Zenaida, Asensio, Eva M., Goday, Albert, Peña-Orihuela, Patricia J., Signes-Pastor, Antonio J., Garcia-Arellano, Ana, Fitó, Montse, Babio, Nancy, and Salas-Salvadó, Jordi

Published
2024
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15. Metabolic syndrome criteria and severity and carbon dioxide (CO2) emissions in an adult population

Author

García, Silvia, Pastor, Rosario, Monserrat-Mesquida, Margalida, Álvarez-Álvarez, Laura, Rubín-García, María, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Goday, Albert, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, Lopez-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Serra-Majem, Lluís, Riquelme-Gallego, Blanca, Pintó, Xavier, Gaforio, José J., Matía, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Sayón-Orea, Carmen, Guillem-Saiz, Patricia, Valle-Hita, Cristina, Cabanes, Robert, Abete, Itziar, Goicolea-Güemez, Leire, Gómez-Gracia, Enrique, Tercero-Maciá, Cristina, Colom, Antoni, García-Ríos, Antonio, Castro-Barquero, Sara, Fernández-García, José C., Santos-Lozano, José Manuel, Cenoz, Juan Carlos, Barragán, Rocío, Khoury, Nadine, Castañer, Olga, Zulet, María Ángeles, Vaquero-Luna, Jessica, Bes-Rastrollo, Maira, de las Heras-Delgado, Sara, Ciurana, Ramon, Martín-Sánchez, Vicente, Tur, Josep A., and Bouzas, Cristina

Published
2023
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16. Carbon dioxide (CO2) emissions and adherence to Mediterranean diet in an adult population: the Mediterranean diet index as a pollution level index

Author

García, Silvia, Bouzas, Cristina, Mateos, David, Pastor, Rosario, Álvarez, Laura, Rubín, María, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Goday, Albert, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, Lopez-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Serra-Majem, Lluís, Riquelme-Gallego, Blanca, Pintó, Xavier, Gaforio, José J., Matía, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Bes-Rastrollo, Maira, Guillem-Saiz, Patricia, Nishi, Stephanie, Cabanes, Robert, Abete, Itziar, Goicolea-Güemez, Leire, Gómez-Gracia, Enrique, Signes-Pastor, Antonio José, Colom, Antoni, García-Ríos, Antonio, Castro-Barquero, Sara, Fernández-García, Jose C., Santos-Lozano, José Manuel, Vázquez, Zenaida, Sorlí, José V., Pascual, Maria, Castañer, Olga, Zulet, Maria Angeles, Vaquero-Luna, Jessica, Basterra-Gortari, F. Javier, Babio, Nancy, Ciurana, Ramon, Martín-Sánchez, Vicente, and Tur, Josep A.

Published
2023
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19. Associations between ultra-processed food consumption and kidney function in an older adult population with metabolic syndrome

Author

Valle-Hita, Cristina, Díaz-López, Andrés, Becerra-Tomás, Nerea, Toledo, Estefania, Cornejo-Pareja, Isabel, Abete, Itziar, Sureda, Antoni, Bes-Rastrollo, Maira, Martínez, J. Alfredo, Tinahones, Francisco J., Tur, Josep A., Garcidueñas-Fimbres, Tany E., París-Pallejá, Francisco, Goday, Albert, Goñi-Ruiz, Nuria, Salas-Salvadó, Jordi, and Babio, Nancy

Published
2023
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20. Adipose tissue plasticity in pheochromocytoma patients suggests a role of the splicing machinery in human adipose browning

Author

Castellá, Moisés, Blasco-Roset, Albert, Peyrou, Marion, Gavaldà-Navarro, Aleix, Villarroya, Joan, Quesada-López, Tania, Lorente-Poch, Leyre, Sancho, Juan, Szymczak, Florian, Piron, Anthony, Rodríguez-Fernández, Sonia, Carobbio, Stefania, Goday, Albert, Domingo, Pere, Vidal-Puig, Antonio, Giralt, Marta, Eizirik, Décio L., Villarroya, Francesc, and Cereijo, Rubén

Published
2023
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21. Dietary intake of polychlorinated dibenzo-p-dioxins and furans, adiposity and obesity status.

Author

Khoury, Nadine, Martínez, María Ángeles, Paz-Graniel, Indira, Martínez-González, Miguel Ángel, Corella, Dolores, Castañer, Olga, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Serra-Majem, J. Lluís, Bueno-Cavanillas, Aurora, Tur, Josep A., Sanjurjo, Sergio Cinza, Pintó, Xavier, Gaforio, José Juan, Matía-Martín, Pilar, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emilio, Sayon-Orea, Carmen, Sorlí, Jose V., Pérez-Vega, Karla-Alejandra, Garcia-Rios, Antonio, Bellvert, Nuria Gómez, Gómez-Gracia, Enrique, Zulet, M.A., Chaplin, Alice, Casas, Rosa, Salcedo-Bellido, Inmaculada, Tojal-Sierra, Lucas, Bernal-Lopez, Maria-Rosa, Vázquez-Ruiz, Zenaida, Asensio, Eva M., Goday, Albert, Peña-Orihuela, Patricia J., Signes-Pastor, Antonio J., Garcia-Arellano, Ana, Fitó, Montse, Babio, Nancy, and Salas-Salvadó, Jordi

Published
2023
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23. Comparative effects of glucagon-like peptide-1 receptors agonists, 4-dipeptidyl peptidase inhibitors, and metformin on metabolic syndrome

Author

Bouzas, Cristina, Pastor, Rosario, Garcia, Silvia, Monserrat-Mesquida, Margalida, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Goday, Albert, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Fernández-Barceló, Olga, Vioque, Jesús, Romaguera, Dora, Lopez-Miranda, José, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Serra-Majem, Lluís, Riquelme-Gallego, Blanca, Martín-Sánchez, Vicente, Pintó, Xavier, Delgado-Rodriguez, Miguel, Matía, Pilar, Vidal, Josep, Cardenas-Salas, Jersy-Jair, Daimiel, Lidia, Ros, Emilio, Toledo, Estefanía, Manzanares, Josep M., Gonzalez-Monge, Inmaculada, Muñoz, Miguel-Ángel, Martinez-Urbistondo, Diego, Tojal-Sierra, Lucas, Muñoz-Bravo, Carlos, Miralles-Gisbert, Salvador, Martin, Marian, García-Ríos, Antonio, Castro-Barquero, Sara, Fernández-García, José Carlos, Santos-Lozano, José Manuel, Basterra-Gortari, F. Javier, Gutiérrez-Carrasquilla, Liliana, Guillem-Saiz, Patricia, Satorres, Alba, Abete, Itziar, Sorto-Sanchez, Carolina, Díez-Espino, Javier, Babio, Nancy, Fitó, Montse, and Tur, Josep A.

Published
2023
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24. Acute Pancreatitis

Author

Wong, Jonathan, Goday, Praveen S., Werlin, Steven L., Guandalini, Stefano, editor, and Dhawan, Anil, editor

Published
2022
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26. One-year changes in fruit and vegetable variety intake and cardiometabolic risk factors changes in a middle-aged Mediterranean population at high cardiovascular risk

Author

López-González, Leyre, Becerra-Tomás, Nerea, Babio, Nancy, Martínez-González, Miguel Ángel, Nishi, Stephanie K., Corella, Dolores, Goday, Albert, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, J. Alfredo, Serra-Majem, Luís, Estruch, Ramon, Bernal-López, M. Rosa, Lapetra, José, Pintó, Xavier, Tur, Josep A., López-Miranda, José, Bueno-Cavanillas, Aurora, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Daimiel, Lidia, Martín-Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Vázquez-Ruiz, Zenaida, Martín-Luján, Francisco M., Sorlí, José V., Castañer, Olga, Zulet, M. Angeles, Tojal-Sierra, Lucas, Carabaño-Moral, Rosa, Román-Maciá, Josefa, Rayó, Elena, García-Ríos, Antonio, Casas, Rosa, Gómez-Pérez, Ana M., Santos-Lozano, José M., Buil-Cosiales, Pilar, Asensio, Eva M., Lassale, Camille, Abete, Itziar, Salaverria-Lete, Itziar, Sayón-Orea, Carmen, Schröder, Helmut, and Salas-Salvadó, Jordi

Published
2022
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27. Prospective associations between a priori dietary patterns adherence and kidney function in an elderly Mediterranean population at high cardiovascular risk

Author

Valle-Hita, Cristina, Díaz-López, Andrés, Becerra-Tomás, Nerea, Martínez-González, Miguel A., García, Verónica Ruiz, Corella, Dolores, Goday, Albert, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Serra-Majem, Luís, Cano-Ibáñez, Naomi, Tur, Josep A., Rubín-García, María, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Fontao, Sebastian Mas, Daimiel, Lidia, Ros, Emilio, Toledo, Estefania, Sorlí, José V., Roca, C., Abete, Iztiar, Moreno-Rodriguez, Anai, Crespo-Oliva, Edelys, Candela-García, Inmaculada, Morey, Marga, Garcia-Rios, Antonio, Casas, Rosa, Fernandez-Garcia, Jose Carlos, Santos-Lozano, José Manuel, Diez-Espino, Javier, Ortega-Azorín, Carolina, Comas, M., Zulet, M. Angeles, Sorto-Sanchez, Carolina, Ruiz-Canela, Miguel, Fitó, Montse, Salas-Salvadó, Jordi, and Babio, Nancy

Published
2022
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29. Web-based cognitive-behavioral intervention for pain in pediatric acute recurrent and chronic pancreatitis: Protocol of a multicenter randomized controlled trial from the study of chronic pancreatitis, diabetes and pancreatic cancer (CPDPC)

Author

Palermo, Tonya M, Murray, Caitlin, Aalfs, Homer, Abu-El-Haija, Maisam, Barth, Bradley, Bellin, Melena D, Ellery, Kate, Fishman, Douglas S, Gariepy, Cheryl E, Giefer, Matthew J, Goday, Praveen, Gonska, Tanja, Heyman, Melvin B, Husain, Sohail Z, Lin, Tom K, Liu, Quin Y, Mascarenhas, Maria R, Maqbool, Asim, McFerron, Brian, Morinville, Veronique D, Nathan, Jaimie D, Ooi, Chee Y, Perito, Emily R, Pohl, John F, Schwarzenberg, Sarah Jane, Sellers, Zachary M, Serrano, Jose, Shah, Uzma, Troendle, David, Zheng, Yuhua, Yuan, Ying, Lowe, Mark, Uc, Aliye, and Pancreatitis, Diabetes and Pancreatic Cancer on behalf of the Consortium for the Study of Chronic

Subjects
Health Services and Systems, Biomedical and Clinical Sciences, Clinical Sciences, Health Sciences, Behavioral and Social Science, Digestive Diseases, Pediatric, Clinical Trials and Supportive Activities, Neurosciences, Prevention, Health Services, Clinical Research, Cancer, Mind and Body, Pain Research, Chronic Pain, Oral and gastrointestinal, Good Health and Well Being, Abdominal Pain, Adolescent, Analgesics, Opioid, Child, Cognitive Behavioral Therapy, Humans, Internet-Based Intervention, Multicenter Studies as Topic, Pain Management, Pain Measurement, Pancreatitis, Pancreatitis, Chronic, Quality of Life, Randomized Controlled Trials as Topic, Recurrence, Children, Chronic pancreatitis, Acute recurrent pancreatitis, Pain, Cognitive-behavioral therapy, Internet intervention, Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer, Medical and Health Sciences, General Clinical Medicine, Public Health, Biomedical and clinical sciences, Health sciences
Abstract

IntroductionAbdominal pain is common and is associated with high disease burden and health care costs in pediatric acute recurrent and chronic pancreatitis (ARP/CP). Despite the strong central component of pain in ARP/CP and the efficacy of psychological therapies for other centralized pain syndromes, no studies have evaluated psychological pain interventions in children with ARP/CP. The current trial seeks to 1) evaluate the efficacy of a psychological pain intervention for pediatric ARP/CP, and 2) examine baseline patient-specific genetic, clinical, and psychosocial characteristics that may predict or moderate treatment response.MethodsThis single-blinded randomized placebo-controlled multicenter trial aims to enroll 260 youth (ages 10-18) with ARP/CP and their parents from twenty-one INSPPIRE (INternational Study Group of Pediatric Pancreatitis: In search for a cuRE) centers. Participants will be randomly assigned to either a web-based cognitive behavioral pain management intervention (Web-based Management of Adolescent Pain Chronic Pancreatitis; WebMAP; N = 130) or to a web-based pain education program (WebED; N = 130). Assessments will be completed at baseline (T1), immediately after completion of the intervention (T2) and at 6 months post-intervention (T3). The primary study outcome is abdominal pain severity. Secondary outcomes include pain-related disability, pain interference, health-related quality of life, emotional distress, impact of pain, opioid use, and healthcare utilization.ConclusionsThis is the first clinical trial to evaluate the efficacy of a psychological pain intervention for children with CP for reduction of abdominal pain and improvement of health-related quality of life. Findings will inform delivery of web-based pain management and potentially identify patient-specific biological and psychosocial factors associated with favorable response to therapy. Clinical Trial Registration #: NCT03707431.

Published
2020

30. One-year longitudinal association between changes in dietary choline or betaine intake and cardiometabolic variables in the PREvención con DIeta MEDiterránea-Plus (PREDIMED-Plus) trial

Author

Díez-Ricote, Laura, San-Cristobal, Rodrigo, Concejo, M José, Martínez-González, Miguel Á, Corella, Dolores, Salas-Salvadó, Jordi, Goday, Albert, Martínez, J Alfredo, Alonso-Gómez, Ángel M, Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J, Lapetra, José, Serra-Majem, Lluís, Bueno-Cavanillas, Aurora, Tur, Josep A, Martín Sánchez, Vicente, Pintó, Xavier, Gaforio, José J, Matía-Martín, Pilar, Vidal, Josep, Mas Fontao, Sebastián, Ros, Emilio, Vázquez-Ruiz, Zenaida, Ortega-Azorín, Carolina, García-Gavilán, Jesús F, Malcampo, Mireia, Martínez-Urbistondo, Diego, Tojal-Sierra, Lucas, García Rodríguez, Antonio, Gómez-Bellvert, Nuria, Chaplin, Alice, García-Ríos, Antonio, Bernal-López, Rosa M, Santos-Lozano, José M, Basterra-Gortari, Javier, Sorlí, José V, Murphy, Michelle, Gasulla, Griselda, Micó, Víctor, Salaverria-Lete, Itziar, Goñi Ochandorena, Estibaliz, Babio, Nancy, Herraiz, Xavier, Ordovás, José M, and Daimiel, Lidia

Published
2022
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31. A commentary on key methodological developments related to nutritional life cycle assessment (nLCA) generated throughout a 6‐year strategic scientific programme

Author

G. A. McAuliffe, T. Takahashi, M. R. F. Lee, A. Jebari, L. Cardenas, A. Kumar, F. Pereyra‐Goday, H. Scalabrino, and A. L. Collins

Subjects
environmental footprints, food systems, net zero, nutritional science, sustainability, synthesis, Agriculture, Agriculture (General), S1-972
Abstract

Abstract Rothamsted Research (RRes) is the world's oldest agricultural research centre, notable for the development of the first synthetic fertilizer (superphosphate) and long‐term farming experiments (LTEs) spanning over 170 years. In 2015, RRes recruited several life cycle assessment (LCA) experts and began adopting the method to utilize high resolution agronomical data covering livestock (primarily ruminants), grassland/forage productivity and quality, and arable systems established on its North Wyke Farm Platform (NWFP) and the LTEs. The NWFP is a UK ‘National Bioscience Research Infrastructure’ (NBRI) developed for informing and testing systems science utilising high‐resolution data to determine whether it is possible to produce nutritious food sustainably. Thanks largely to the multidisciplinary knowledge at RRes, and its collaborators, its LCA Team has been at the forefront of methodological advances during a 6‐year Institute Strategic Programme (ISP) ‘Soil‐to‐Nutrition’ (S2N). While S2N investigated the co‐benefits and trade‐offs of new mechanistic understanding of efficient nutrient use across scales from pot to landscape, this commentary specifically synthesizes progress in incorporating human nutrition in the context of environmental footprinting, known as ‘nutritional LCA’ (nLCA). We conclude our commentary with a brief discussion on future pathways of exploration and methodological developments covering various activities along entire agri‐food supply‐chains.

Published
2023
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32. Association of monetary diet cost of foods and diet quality in Spanish older adults

Author

Cristina Bouzas, Rosario Pastor, Silvia García, Margalida Monserrat-Mesquida, Miguel Ángel Martínez-González, Jordi Salas-Salvadó, Dolores Corella, Helmut Schröder, J. Alfredo Martínez, Ángel M. Alonso-Gómez, Julia Wärnberg, Jesús Vioque, Dora Romaguera, José Lopez-Miranda, Ramon Estruch, Francisco J. Tinahones, José Lapetra, Lluís Serra-Majem, Blanca Riquelme-Gallego, Anny Romero-Secin, Xavier Pintó, José J. Gaforio, Pilar Matía, Josep Vidal, Miriam Zapatero, Lidia Daimiel, Emilio Ros, Ana García-Arellano, Nancy Babio, Inmaculada Gonzalez-Monje, Olga Castañer, Itziar Abete, Lucas Tojal-Sierra, Juan Carlos Benavente-Marín, Antonio Signes-Pastor, Jadwiga Konieczna, Antonio García-Ríos, Sara Castro-Barquero, José C. Fernández-García, José Manuel Santos-Lozano, Maira Bes-Rastrollo, Cristina Mestres, Patricia Guillem-Saiz, Albert Goday, Leire Goicolea-Güemez, Estanislao Puig-Aguiló, Miguel Ruiz-Canela, Antoni Palau-Galindo, Montse Fitó, and Josep A. Tur

Subjects
monetary cost, Mediterranean diet, provegetarian dietary pattern, dietary inflammatory index, metabolic syndrome, Public aspects of medicine, RA1-1270
Abstract

BackgroundA major barrier to a healthy diet may be the higher price of healthy foods compared to low-quality foods.ObjectivesThis study aimed to assess the association between the monetary cost of food and diet quality in Spanish older adults at high risk of cardiovascular disease.MethodsCross-sectional analysis was carried out in Spanish older adults (n = 6,838; 48.6% female). A validated food frequency questionnaire was used to assess dietary intake. Metabolic syndrome severity, adherence to the Mediterranean diet (MedDiet), adherence to a provegetarian dietary pattern, and dietary inflammatory index were assessed. The economic cost of the foods was obtained from the Spanish Ministry of Agriculture Fisheries and Food database (2015–2017, the period of time when the participants were recruited). The total cost of diet adjusted per 1,000 kcal was computed.ResultsThe healthier dietary pattern was associated with a higher cost of the diet. Higher adherence to the MedDiet, anti-inflammatory diet, and the healthy version of the provegetarian dietary pattern were related to higher costs of the diet.ConclusionHigher diet quality was associated with a higher dietary cost of the diet per 1,000 kcal/day. Food prices can be an important component of interventions and policies aimed at improving people's diets and preventing diet-related chronic diseases.Clinical trial registry numberThe trial was registered in 2014 at the International Standard Randomized Controlled Trial (ISRCT; http://www.isrctn.com/ISRCTN89898870) with the number 89898870.

Published
2023
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35. Longitudinal association of dietary carbohydrate quality with visceral fat deposition and other adiposity indicators

Author

Zamanillo-Campos, Rocío, Chaplin, Alice, Romaguera, Dora, Abete, Itziar, Salas-Salvadó, Jordi, Martín, Vicente, Estruch, Ramón, Vidal, Josep, Ruiz-Canela, Miguel, Babio, Nancy, Fiol, Francisca, de Paz, José Antonio, Casas, Rosa, Olbeyra, Romina, Martínez-González, Miguel A., García-Gavilán, Jesús F., Goday, Albert, Fernandez-Lazaro, Cesar I., Martínez, J. Alfredo, Hu, Frank B., and Konieczna, Jadwiga

Published
2022
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37. Factors associated with successful dietary changes in an energy-reduced Mediterranean diet intervention: a longitudinal analysis in the PREDIMED-Plus trial

Author

Fernandez-Lazaro, Cesar I., Toledo, Estefanía, Buil-Cosiales, Pilar, Salas-Salvadó, Jordi, Corella, Dolores, Fitó, Montserrat, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Serra-Majem, Luís, Bueno-Cavanillas, Aurora, Tur, Josep A., Martín Sánchez, Vicente, Pintó, Xavier, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Vidal, Josep, Ros, Emilio, Vázquez, Clotilde, Daimiel, Lidia, SanJulián, Beatriz, García-Gavilán, Jesús F., Sorlí, Jose V., Castañer, Olga, Zulet, M. Ángeles, Tojal-Sierra, Lucas, Pérez-Farinós, Napoleón, Oncina-Canovas, Alejandro, Moñino, Manuel, Garcia-Rios, Antonio, Sacanella, Emilio, Bernal-Lopez, Rosa M., Santos-Lozano, José Manuel, Vázquez-Ruiz, Zenaida, Muralidharan, Jananee, Ortega-Azorín, Carolina, Goday, Alberto, Razquin, Cristina, Goicolea-Güemez, Leire, Ruiz-Canela, Miguel, Becerra-Tomás, Nerea, Schröder, Helmut, and Martínez González, Miguel A.

Published
2022
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38. Inflammatory potential of diet and bone mineral density in a senior Mediterranean population: a cross-sectional analysis of PREDIMED-Plus study

Author

García-Gavilán, Jesús F., Paz-Graniel, Indira, Babio, Nancy, Romaguera, Dora, Martínez, Jose Alfredo, Martin, Vicente, Martínez, María Ángeles, Konieczna, Jadwiga, Ruiz-Canela, Miguel, de Paz Fernandez, José Antonio, Goday, Albert, Martínez-González, Miguel Ángel, Bulló, Mònica, and Salas-Salvadó, Jordi

Published
2022
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39. Heterogeneity in the association between prediabetes categories and reduction on glomerular filtration rate in a 5-year follow-up

Author

Marjan Manouchehri, Lucía Cea-Soriano, Josep Franch-Nadal, Antonio Ruiz, Albert Goday, Rosa Villanueva, Javier Diez-Espino, Manel Mata-Cases, Carolina Giraldez-García, Enrique Regidor, and The PREDAPS Study Group

Subjects
Medicine, Science
Abstract

Abstract Prediabetes and not just diabetes can cause kidney damage. This study assess the association of prediabetes with development of impaired renal function (IRF). We used data from PREDAPS prospective study a cohort of 1072 subjects with prediabetes and another cohort of 772 subjects without prediabetes were follow-up from 2012 to 2017. Prediabetes was defined according to American Association of Diabetes criteria. IRF was defined as having a glomerular filtration rate

Published
2022
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42. Corrigendum: Role of NAFLD on the health related QoL response to lifestyle in patients with metabolic syndrome: The PREDIMED plus cohort

Author

Diego Martínez-Urbistondo, Rodrigo San-Cristóbal, Paula Villares, Miguel Ángel Martínez-González, Nancy Babio, Dolores Corella, José Luis del Val, José Ma Ordovás, Ángel M. Alonso-Gómez, Julia Wärnberg, Jesús Vioque, Dora Romaguera, José López-Miranda, Ramon Estruch, Francisco J. Tinahones, José Lapetra, J. Luís Serra-Majem, Aurora Bueno-Cavanillas, Josep A. Tur, Alba Marcos, Xavier Pintó, Miguel Delgado-Rodríguez, Pilar Matía-Martín, Josep Vidal, Clotilde Vázquez, Emilio Ros, María Vanessa Bullón Vela, Antoni Palau, Jose V. Sorli, Marta Masagué, Itziar Abete, Anai Moreno-Rodríguez, Inma Candela-García, Jadwiga Konieczna, Antonio García-Ríos, Oscar Lecea Juárez, Olga Portolés, Paco Martín, Albert Goday, M. Ángeles Zulet, Jessica Vaquero-Luna, María del Carmen Sayón Orea, Isabel Megías, Enric Baltasar, J. Alfredo Martínez, and Lidia Daimiel

Subjects
NAFLD, metabolic syndrome, mediterranean diet, physical activity, HRQoL, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Published
2023
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43. Impact of COVID-19 pandemic on the PREDIMED-Plus randomized clinical trial: Effects on the interventions, participants follow-up, and adiposity

Author

Indira Paz-Graniel, Montserrat Fitó, Emilio Ros, Pilar Buil-Cosiales, Dolores Corella, Nancy Babio, J. Alfredo Martínez, Ángel M. Alonso-Gómez, Julia Wärnberg, Jesús Vioque, Dora Romaguera, José López-Miranda, Ramon Estruch, Francisco J. Tinahones, José Lapetra, Lluis Serra-Majem, Aurora Bueno-Cavanillas, Josep A. Tur, Vicente Martín-Sánchez, Xavier Pintó, José Juan Gaforio, Pilar Matía-Martín, Josep Vidal, Clotilde Vázquez, Lidia Daimiel, Jesus F. García-Gavilán, Estefanía Toledo, Stephanie K. Nishi, Jose V. Sorlí, Olga Castañer, Antonio García-Ríos, Manoli García de la Hera, Francisco Javier Barón-López, Miguel Ruiz-Canela, Marga Morey, Rosa Casas, Eva María Garrido-Garrido, Lucas Tojal-Sierra, José C. Fernández-García, Zenaida Vázquez-Ruiz, Rebeca Fernández-Carrión, Albert Goday, Patricia J. Peña-Orihuela, Laura Compañ-Gabucio, Helmut Schröder, Miguel A. Martínez-Gonzalez, and Jordi Salas-Salvadó

Subjects
COVID-19, PREDIMED-Plus, lockdown, clinical trial, weight-loss, Mediterraean diet, Nutrition. Foods and food supply, TX341-641
Abstract

BackgroundThe COVID-19 pandemic has affected the implementation of most ongoing clinical trials worldwide including the PREDIMED-Plus study. The PREDIMED-Plus is an ongoing, multicenter, controlled intervention trial, aimed at weight-loss and cardiovascular disease prevention, in which participants were randomized (1:1 ratio) to an intervention group (energy-reduced Mediterranean diet, promotion of physical activity, and behavioral support) or to a control group (Mediterranean diet with usual care advice). When the pandemic began, the trial was in the midst of the planned intervention. The objective of this report was to examine the effects of the pandemic on the delivery of the intervention and to describe the strategies established to mitigate the possible adverse effects of the pandemic lockdown on data collection and adiposity.MethodsWe assessed the integrity of the PREDIMED-Plus trial during 5 identified periods of the COVID-19 pandemic determined according to restrictions dictated by the Spanish government authorities. A standardized questionnaire was delivered to each of the 23 PREDIMED-Plus recruiting centers to collected data regarding the trial integrity. The effect of the restrictions on intervention components (diet, physical activity) was evaluated with data obtained in the three identified lockdown phases: pre lockdown, lockdown proper, and post lockdown.ResultsDuring the lockdown (March/2020-June/2021), 4,612 participants (48% women, mean age 65y) attended pre-specified yearly follow-up visits to receive lifestyle recommendations and obtain adiposity measures. The overall mean (SD) of the proportions reported by each center showed that 40.4% (25.4) participants had in-person visits, 39.8% (18.2) participants were contacted by telephone and 35% (26.3) by electronic means. Participants’ follow-up and data collection rates increased across lockdown periods (from ≈10% at onset to ≈80% at the end). Compared to pre-lockdown, waist circumference increased during (0.75 cm [95% CI: 0.60–0.91]) and after (0.72 cm [95% CI: 0.56–0.89]) lockdown. Body weight did not change during lockdown (0.01 kg [95% CI: –0.10 to 0.13) and decreased after lockdown (-0.17 kg [95% CI: –0.30 to –0.04]).ConclusionMitigating strategies to enforce the intervention and patient’s follow-up during lockdown have been successful in preserving the integrity of the trial and ensuring its continuation, with minor effects on adiposity.Clinical trial registrationhttps://doi.org/10.1186/ISRCTN89898870, identifier ISRCTN89898870.

Published
2023
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44. Obesity and related comorbidities in a large population-based cohort of subjects with type 1 diabetes in Catalonia

Author

Idoia Genua, Josep Franch-Nadal, Elena Navas, Manel Mata-Cases, Gabriel Giménez-Pérez, Bogdan Vlacho, Didac Mauricio, and Albert Goday

Subjects
Obesity, type 1 diabetes, cardiovascular risk factors, metabolic syndrome, comorbidities, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

IntroductionObesity, an increasing global health problem, can affect people with other disease conditions. The prevalence of obesity in people with type 1 diabetes (T1D) is not well known. The aim of this study was to describe extensively the characteristics and prevalence of different classes of obesity according to BMI (body mass index) categories in a large cohort of patients with T1D.Material and methodsThis was a retrospective, cross-sectional study in Catalonia. We reviewed all patients with T1D diagnosis, ≥ 18 years old and with BMI data from the SIDIAP database. Sociodemographic and clinical data, cardiovascular risk factors, laboratory parameters and concomitant medications were collected.ResultsA total of 6,068 patients with T1D were analyzed. The prevalence of obesity in the total sample was 18% (13.8% with class 1 obesity [BMI 30-34.9 kg/m2]). Patients with obesity had a higher prevalence of other cardiovascular risk factors (i.e. hypertension was 61.4% vs. 37.5%; dyslipidemia 63.6% vs 44%, and chronic kidney disease 38.4% vs. 24.4%; p 25 kg/m2. Patients with obesity did not have poorer glycemic control.ConclusionThe presence of obesity in people with T1D is frequent and cardiovascular risk factors are more common and more poorly controlled in T1D patients with obesity.

Published
2022
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46. Physical activity and metabolic syndrome severity among older adults at cardiovascular risk: 1-Year trends

Author

Gallardo-Alfaro, Laura, Bibiloni, Maria del Mar, Bouzas, Cristina, Mascaró, Catalina M., Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Corella, Dolores, Schröder, Helmut, Martínez, J. Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, Lopez-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Lapetra, José, Serra-Majem, Luís, Bueno-Cavanillas, Aurora, Micó, Rafael M., Pintó, Xavier, Gaforio, José J., Ortíz-Ramos, María, Altés-Boronat, Andreu, Luca, Bogdana L., Daimiel, Lidia, Ros, Emilio, Sayon-Orea, Carmen, Becerra-Tomás, Nerea, Gimenez-Alba, Ignacio Manuel, Castañer, Olga, Abete, Itziar, Tojal-Sierra, Lucas, Pérez-López, Jéssica, Torres-Collado, Laura, Colom, Antoni, Garcia-Rios, Antonio, Castro-Barquero, Sara, Bernal, Rosa, Santos-Lozano, José Manuel, Fernandez-Lazaro, Cesar I., Hernández-Alonso, Pablo, Saiz, Carmen, Zomeño, Maria Dolors, Zulet, Maria Angeles, Belló-Mora, Maria C., Basterra-Gortari, F. Javier, Canudas, Silvia, Goday, Albert, and Tur, Josep A.

Published
2021
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49. Variety in fruits and vegetables, diet quality and lifestyle in an older adult mediterranean population

Author

López-González, Leyre, Becerra-Tomás, Nerea, Babio, Nancy, Martínez-González, Miguel Ángel, Díaz-López, Andrés, Corella, Dolores, Goday, Albert, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, J. Alfredo, Serra-Majem, Luís, Estruch, Ramón, Tinahones, Francisco, Lapetra, José, Pintó, Xavier, Tur, Josep A., López-Miranda, José, Bueno-Cavanillas, Aurora, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Daimiel, Lidia, Álvarez-Álvarez, Laura, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Vázquez-Ruiz, Zenaida, Canudas, Silvia, Carrión, Rebeca Fernández, Castañer, Olga, Zulet, M.Ángeles, Sierra, Lucas Tojal, Ajejas Bazán, María Julia, López García, Carmen M., Martín, Marian, García-Ríos, Antonio, Casas, Rosa, Gómez-Pérez, Ana M., Santos-Lozano, José Manuel, Goñi, Estíbaliz, Guillem-Saiz, Patricia, Lassale, Camile, Abete, Itziar, Lete, Itziar Salaverria, Eguaras, Sonia, Schröder, Helmut, and Salas-Salvadó, Jordi

Published
2021
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50. Mid- and long-term changes in satiety-related hormones, lipid and glucose metabolism, and inflammation after a Mediterranean diet intervention with the goal of losing weight: A randomized, clinical trial

Author

J Hernando-Redondo, A Toloba, D Benaiges, J Salas-Salvadó, MA Martínez-Gonzalez, D Corella, R Estruch, FJ Tinahones, E Ros, A Goday, O Castañer, and M Fitó

Subjects
metabolic syndrome, Mediterranean diet (MedDiet), leptin, PAI-1, inflammation, Nutrition. Foods and food supply, TX341-641
Abstract

BackgroundObesity is produced by the enlargement of the adipose tissue. Functioning as an endocrine organ, it releases and receives information through a complex network of cytokines, hormones, and substrates contributing to a low-chronic inflammation environment. Diet and healthy habits play key roles in the prevention of obesity and its related pathologies. In this regard, there is a need to switch to healthier and more appetizing diets, such as the Mediterranean one.ObjectiveTo compare the mid-and long-term effects of two Mediterranean diet (MedDiet) interventions, one energy-reduced plus physical activity promotion versus a non-restrictive diet, on peripheral satiety-related hormones, weight loss, glucose/lipid metabolism, and pro-inflammatory markers in subjects with obesity/overweight and metabolic syndrome.Materials and methodsA randomized, lifestyle intervention was conducted in 23 Spanish centers, with a large cohort of patients presenting metabolic syndrome. Our study is a subproject set in IMIM (Hospital del Mar Research Institute). Participants were men and women, aged 55–75 and 60–75, respectively, who at baseline met at least three metabolic syndrome components. Subjects were assigned to two intervention groups: (1) an intensive lifestyle intervention with an energy-reduced MedDiet and physical activity promotion (intervention group) with the aim of weight loss; and (2) a normocaloric MedDiet (control). We quantified in a subsample of 300 volunteers from Hospital del Mar Research Institute (Barcelona), following analytes at baseline, 6 months, and 1 year: glucose, HbA1c, triglycerides, total cholesterol, high-density lipoprotein cholesterol, LDL cholesterol, C-peptide, ghrelin, GLP-1, glucagon, insulin, leptin, PAI-1, resistin, and visfatin. Anthropometric and classical cardiovascular risk factors were also determined. A multivariate statistical model was employed to compare the two groups. Linear mixed-effect models were performed to compare changes in risk factors and biomarkers between intervention groups and over time.ResultsCompared to participants in the control group, those in intervention one showed greater improvements in weight, waist circumference, insulin (P < 0.001), glucose metabolism-related compounds (P < 0.05), triglyceride-related lipid profile (P < 0.05), leptin, blood pressure, and pro-inflammatory markers such as PAI-1 (P < 0.001) at mid-and/or long-term. High-sensitivity C-reactive protein, resistin, and vifastin also decreased in both groups.ConclusionA weight loss intervention employing a hypocaloric MedDiet and physical activity promotion has beneficial effects on adiposity, glucose metabolism, lipid profile, leptin, and pro-inflammatory markers, such as PAI-1 in both mid-and long-term.

Published
2022
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