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Abstract Background Alongside the benefits of Total-Body imaging modalities, such as higher sensitivity, single-bed position, low dose imaging, etc., their final construction cost prevents worldwide utilization. The main aim of this study is to present a simulation-based comparison of the sensitivities of existing and currently developed tomographs to introduce a cost-efficient solution for constructing a Total-Body PET scanner based on plastic scintillators. Methods For the case of this study, eight tomographs based on the uEXPLORER configuration with different scintillator materials (BGO, LYSO), axial field-of-view (97.4 cm and 194.8 cm), and detector configurations (full and sparse) were simulated. In addition, 8 J-PET scanners with different configurations, such as various axial field-of-view (200 cm and 250 cm), different cross sections of plastic scintillator, and multiple numbers of plastic scintillator layers (2, 3, and 4), based on J-PET technology have been simulated by GATE software. Furthermore, Siemens’ Biograph Vision has been simulated to compare the results with standard PET scans. Two types of simulations have been performed. The first one with a centrally located source with a diameter of 1 mm and a length of 250 cm, and the second one with the same source inside a water-filled cylindrical phantom with a diameter of 20 cm and a length of 183 cm. Results With regards to sensitivity, among all the proposed scanners, the ones constructed with BGO crystals give the best performance ( $$\sim$$ ∼ 350 cps/kBq at the center). The utilization of sparse geometry or LYSO crystals significantly lowers the achievable sensitivity of such systems. The J-PET design gives a similar sensitivity to the sparse LYSO crystal-based detectors while having full detector coverage over the body. Moreover, it provides uniform sensitivity over the body with additional gain on its sides and provides the possibility for high-quality brain imaging. Conclusion Taking into account not only the sensitivity but also the price of Total-Body PET tomographs, which till now was one of the main obstacles in their widespread clinical availability, the J-PET tomography system based on plastic scintillators could be a cost-efficient alternative for Total-Body PET scanners.

Abstract Background The Jagiellonian Positron Emission Tomograph is the 3-layer prototype of the first scanner based on plastic scintillators, consisting of 192 half-metre-long strips with readouts at both ends. Compared to crystal-based detectors, plastic scintillators are several times cheaper and could be considered as a more economical alternative to crystal scintillators in future PETs. JPET is also a first multi-photon PET prototype. For the development of multi-photon detection, with photon characterized by the continuous energy spectrum, it is important to estimate the efficiency of J-PET as a function of energy deposition. The aim of this work is to determine the registration efficiency of the J-PET tomograph as a function of energy deposition by incident photons and the intrinsic efficiency of the J-PET scanner in detecting photons of different incident energies. In this study, 3-hit events are investigated, where 2-hits are caused by 511 keV photons emitted in $$e^+e^-$$ e + e - annihilations, while the third hit is caused by one of the scattered photons. The scattered photon is used to accurately measure the scattering angle and thus the energy deposition. Two hits by a primary and a scattered photon are sufficient to calculate the scattering angle of a photon, while the third hit ensures the precise labeling of the 511 keV photons. Results By comparing experimental and simulated energy distribution spectra, the registration efficiency of the J-PET scanner was determined in the energy deposition range of 70–270 keV, where it varies between 20 and 100 $$\%$$ % . In addition, the intrinsic efficiency of the J-PET was also determined as a function of the energy of the incident photons. Conclusion A method for determining registration efficiency as a function of energy deposition and intrinsic efficiency as a function of incident photon energy of the J-PET scanner was demonstrated. This study is crucial for evaluating the performance of the scanner based on plastic scintillators and its applications as a standard and multi-photon PET systems. The method may be also used in the calibration of Compton-cameras developed for the ion−beam therapy monitoring and simultaneous multi-radionuclide imaging in nuclear medicine.

Tests of the T, CP and CPT symmetries in the neutral kaon system are performed by the direct comparison of the probabilities of a kaon transition process to its symmetry-conjugate. The exchange of in and out states required for a genuine test involving an antiunitary transformation implied by time-reversal is implemented exploiting the entanglement of K0K‾0 pairs produced at a ϕ-factory.A data sample collected by the KLOE experiment at DAΦNE corresponding to an integrated luminosity of about 1.7 fb−1 is analysed to study the Δt distributions of the ϕ→KSKL→π+π−π±e∓ν and ϕ→KSKL→π±e∓ν3π0 processes, with Δt the difference of the kaon decay times. A comparison of the measured Δt distributions in the asymptotic region Δt≫τS allows to test for the first time T and CPT symmetries in kaon transitions with a precision of few percent, and to observe CP violation with this novel method.

Abstract The ratio R $$ \mathcal{R} $$ = Γ(K S → πeν)/Γ(K S → π + π − ) has been measured with a sample of 300 million K S mesons produced in ϕ → K L K S decays recorded by the KLOE experiment at the DAΦNE e + e − collider. K S → πeν events are selected by a boosted decision tree built with kinematic variables and time-of-flight measurements. Data control samples of K L → πeν decays are used to evaluate signal selection efficiencies. With 49647±316 signal events we measure R $$ \mathcal{R} $$ = (1.0421 ± 0.0066stat ± 0.0075syst) × 10 −3. The combination with our previous measurement gives R $$ \mathcal{R} $$ = (1.0338 ± 0.0054stat ± 0.0064syst) × 10 −3. From this value we derive the branching fraction B $$ \mathcal{B} $$ (K S → πeν) = (7.153 ± 0.037stat ± 0.044syst) × 10 −4 and f +(0)|V us | = 0.2170 ± 0.009.

Abstract The quantum interference between the decays of entangled neutral kaons is studied in the process ϕ → KSKL → π + π − π + π − , which exhibits the characteristic Einstein-Podolsky-Rosen correlations that prevent both kaons to decay into π + π − at the same time. This constitutes a very powerful tool for testing at the utmost precision the quantum coherence of the entangled kaon pair state, and to search for tiny decoherence and CPT $$ \mathcal{CPT} $$ violation effects, which may be justified in a quantum gravity framework. The analysed data sample was collected with the KLOE detector at DAΦNE, the Frascati ϕ-factory, and corresponds to an integrated luminosity of about 1.7 fb −1, i.e. to about 1.7 × 109 ϕ → KSKL decays produced. From the fit of the observed ∆t distribution, being ∆t the difference of the kaon decay times, the decoherence and CPT $$ \mathcal{CPT} $$ violation parameters of various phenomenological models are measured with a largely improved accuracy with respect to previous analyses. The results are consistent with no deviation from quantum mechanics and CPT $$ \mathcal{CPT} $$ symmetry, while for some parameters the precision reaches the interesting level at which — in the most optimistic scenarios — quantum gravity effects might show up. They provide the most stringent limits up to date on the considered models.

CPT violation could manifest itself in annihilating positronium events, but searching for this effect would require to know the spin of the annihilating system. Here, the authors do this using a positron-emission tomography scanner, finding no violation with a statistical precision of 10−4.

We examined the prevalence of self-reported motivations and barriers to helping intoxicated peers among emerging adults (N = 377; M[subscript age] = 18.64; 75% women, 88% White) attending a Southeastern university and whether motivations and barriers differed by age, gender, race, and class standing. Respondents aged 19-24 were more likely to endorse the motivation item "Because it was your "turn" to be the helper/designated driver (DD) that night" than eighteen-year-olds. Race differences were also reported for the motivation item, "Because the person was your friend", where White participants were more likely to endorse this item than non-White participants. Men also reported more Burden/Hassles-related barriers than did women.

Abstract Based on an integrated luminosity of 1.61 fb −1 e + e − collision data collected with the KLOE detector at DAΦNE, the Frascati ϕ-factory, a search for the P- and CP-violating decay η → π + π − has been performed. Radiative ϕ → ηγ decay is exploited to access the η mesons. No signal is observed in the π + π − invariant mass spectrum, and the upper limit on the branching fraction at 90% confidence level is determined to be ℬ(η → π + π − ) < 4.9 × 10 −6, which is approximately three times smaller than the previous KLOE result. From the combination of these two measurements we get ℬ(η → π + π − ) < 4.4 × 10 −6 at 90% confidence level.

Abstract Purpose The time-over-threshold (TOT) technique is being used widely due to itsimplications in developing the multi-channel readouts, mainly when fast signal processing is required. Using the TOT technique, as a measure of energy loss instead of charge integration methods, significantly reduces the signal readout costs by combining the time and energy information. Therefore, this approach can potentially be utilized in J-PET tomograph which is built from plastic scintillators characterized by fast light signals. The drawback in adopting this technique lies in the non-linear correlation between input energy loss and TOT of the signal. The main motivation behind this work is to develop the relationship between TOT and energy loss and validate it by the J-PET tomograph setup. Methods The experiment was performed using a 22Na beta emitter source placed in the center of the J-PET tomograph. This isotope produces photons of two different energies: 511 keV photons from the positron annihilation (direct annihilation or through the formation of a para-positronium atom or pick-off process of ortho-positronium atoms) and a 1275 keV prompt photon. This allows the study of the correlation between TOT values and energy loss for energy ranges up to 1000 keV. Since the photon interacts predominantly via Compton scattering inside the plastic scintillator, there is no direct information of the energy deposition. However, using the J-PET geometry, one can measure the scattering angle of the interacting photon. Since the 22Na source emits photons of two different energies, it is necessary to know unambiguously the energy of incident photons and their corresponding scattering angles in order to estimate energy deposition. In summary, this work presents a dedicated algorithm developed to tag photons of different energies and studying their scattering angles to calculate the energy deposition by the interacting photons. Results A new method was elaborated to measure the energy loss by photons interacting with plastic scintillators used in the J-PET tomograph. We find the relationship between the energy loss and TOT is non-linear and can be described by the functions TOT = A0 + A1 * ln(E dep + A2) + A3 * (ln(E dep + A2))2 and TOT = A0 - A1 * A2 E dep $^{E_{dep}}\phantom {\dot {i}\!}$ . In addition, we also introduced a theoretical model to calculate the TOT as a function of energy loss in plastic scintillators. Conclusions A relationship between TOT and energy loss by photons interacting inside the plastic scintillators used in J-PET scanner is established for a deposited energy range of 100–1000 keV.

Abstract Purpose In living organisms, the positron-electron annihilation (occurring during the PET imaging) proceeds in about 30% via creation of a metastable ortho-positronium atom. In the tissue, due to the pick-off and conversion processes, over 98% of ortho-positronia annihilate into two 511 keV photons. In this article, we assess the feasibility for reconstruction of the mean ortho-positronium lifetime image based on annihilations into two photons. The main objectives of this work include the (i) estimation of the sensitivity of the total-body PET scanners for the ortho-positronium mean lifetime imaging using 2γ annihilations and (ii) estimation of the spatial and time resolution of the ortho-positronium image as a function of the coincidence resolving time (CRT) of the scanner. Methods Simulations are conducted assuming that radiopharmaceutical is labeled with 44 S c isotope emitting one positron and one prompt gamma. The image is reconstructed on the basis of triple coincidence events. The ortho-positronium lifetime spectrum is determined for each voxel of the image. Calculations were performed for cases of total-body detectors build of (i) LYSO scintillators as used in the EXPLORER PET and (ii) plastic scintillators as anticipated for the cost-effective total-body J-PET scanner. To assess the spatial and time resolution, the four cases were considered assuming that CRT is equal to 500 ps, 140 ps, 50 ps, and 10 ps. Results The estimated total-body PET sensitivity for the registration and selection of image forming triple coincidences (2γ+γ prompt) is larger by a factor of 13.5 (for LYSO PET) and by factor of 5.2 (for plastic PET) with respect to the sensitivity for the standard 2γ imaging by LYSO PET scanners with AFOV = 20 cm. The spatial resolution of the ortho-positronium image is comparable with the resolution achievable when using TOF-FBP algorithms already for CRT = 50 ps. For the 20-min scan, the resolution better than 20 ps is expected for the mean ortho-positronium lifetime image determination. Conclusions Ortho-positronium mean lifetime imaging based on the annihilations into two photons and prompt gamma is shown to be feasible with the advent of the high sensitivity total-body PET systems and time resolution of the order of tens of picoseconds.

Based on a sample of 300 million KS mesons produced in ϕ→KLKS decays recorded by the KLOE experiment at the DAΦNE e+e− collider we have measured the branching fraction for the decay KS→πμν. The KS mesons are identified by the interaction of KL mesons in the detector. The KS→πμν decays are selected by a boosted decision tree built with kinematic variables and by a time-of-flight measurement. Signal efficiencies are evaluated with data control samples of KL→πμν decays. A fit to the reconstructed muon mass distribution finds 7223±180 signal events. Normalising to the KS→π+π− decay events the result for the branching fraction is B(KS→πμν)=(4.56±0.11stat±0.17syst)×10−4. It is the first measurement of this decay mode and the result allows an independent determination of |Vus| and a test of the lepton-flavour universality. Keywords: e+e− collisions, K0 meson, Semileptonic decay

J-PET Framework is an open-source software platform for data analysis, written in C++ and based on the ROOT package. It provides a common environment for implementation of reconstruction, calibration and filtering procedures, as well as for user-level analyses of Positron Emission Tomography data. The library contains a set of building blocks that can be combined by users with even little programming experience, into chains of processing tasks through a convenient, simple and well-documented API. The generic input–output interface allows processing the data from various sources: low-level data from the tomography acquisition system or from diagnostic setups such as digital oscilloscopes, as well as high-level tomography structures e.g. sinograms or a list of lines-of-response. Moreover, the environment can be interfaced with Monte Carlo simulation packages such as GEANT and GATE, which are commonly used in the medical scientific community.

Abstract J-PET is a detector optimized for registration of photons from the electron–positron annihilation via plastic scintillators where photons interact predominantly via Compton scattering. Registration of both primary and scattered photons enables to determinate the linear polarization of the primary photon on the event by event basis with a certain probability. Here we present quantitative results on the feasibility of such polarization measurements of photons from the decay of positronium with the J-PET and explore the physical limitations for the resolution of the polarization determination of 511 keV photons via Compton scattering. For scattering angles of about 82$$^\circ $$ ∘ (where the best contrast for polarization measurement is theoretically predicted) we find that the single event resolution for the determination of the polarization is about 40$$^\circ $$ ∘ (predominantly due to properties of the Compton effect). However, for samples larger than ten thousand events the J-PET is capable of determining relative average polarization of these photons with the precision of about few degrees. The obtained results open new perspectives for studies of various physics phenomena such as quantum entanglement and tests of discrete symmetries in decays of positronium and extend the energy range of polarization measurements by five orders of magnitude beyond the optical wavelength regime.

We searched for the μ+μ− decay of a light vector gauge boson, also known as dark photon, in the e+e−→μ+μ−γISR process by means of the Initial State Radiation (ISR) method. We used 1.93 fb−1 of data collected by the KLOE experiment at the DAΦNE ϕ-factory. No structures have been observed over the irreducible μ+μ− background. A 90% CL limit on the ratio ε2=α′/α between the dark coupling constant and the fine structure constant of 3×10−6–2×10−7 has been set in the dark photon mass region between 519 MeV and 973 MeV. This new limit has been combined with the published result obtained investigating the hypothesis of the dark photon decaying into hadrons in e+e−→π+π−γISR events. The combined 90% CL limit increases the sensitivity especially in the ρ–ω interference region and excludes ε2 greater than (13−2)×10−7. For dark photon masses greater than 600 MeV the combined limit is lower than 8 ×10−7 resulting more stringent than present constraints from other experiments. Keywords: e+e− Collisions, Dark forces, Gauge vector boson, Upper limits

Abstract Using 1.63 fb−1 of integrated luminosity collected by the KLOE experiment about 7 × 104 K S → π ± e ∓ ν decays have been reconstructed. The measured value of the charge asymmetry for this decay is A S = (−4.9 ± 5.7stat ± 2.6syst) × 10−3, which is almost twice more precise than the previous KLOE result. The combination of these two measurements gives A S = (−3.8 ± 5.0stat ± 2.6syst) × 10−3 and, together with the asymmetry of the K L semileptonic decay, provides significant tests of the CPT symmetry. The obtained results are in agreement with CPT invariance.

Abstract The three precision measurements of the cross section σ(e + e − → π + π −γ(γ)) using initial state radiation by the KLOE collaboration provide an important input for the prediction of the hadronic contribution to the anomalous magnetic moment of the muon. These measurements are correlated for both statistical and systematic uncertainties and, therefore, the simultaneous use of these measurements requires covariance matrices that fully describe the correlations. We present the construction of these covariance matrices and use them to determine a combined KLOE measurement for σ(e + e − → π + π −γ(γ)). We find, from this combination, a two-pion contribution to the muon magnetic anomaly in the energy range 0.10 < s < 0.95 GeV2 of a μ π + π − = 489.8 ± 1.7 stat ± 4.8 s y s × 10 − 10 $$ {a}_{\mu}^{\pi^{+}{\pi}^{-}}=\left(489.8\pm {1.7}_{\mathrm{stat}}\pm {4.8}_{\mathrm{sys}}\right)\times {10}^{-10} $$ . Data vectors and covariance matrices are available at http://www.lnf.infn.it/kloe/ppg/ ppg_2017/ppg_2017.html .

We have measured the running of the effective QED coupling constant α(s) in the time-like region 0.6

The CDC reports that 30% of high school students have engaged in sexual intercourse. Evidence suggests biological, personal, peer, societal, and family variables affect when a child will initiate sex. The school environment plays an important role in a child's development. Evidence suggests that greater attachment to the school community can modify sexual risk-taking activity in adolescents. Future of Families and Child Wellbeing Study (FFCWS) comprises a cohort of approximately 4,700 families of children born in the U.S. between 1998-2000, over-sampled for non-marital births in large U.S. cities. Adolescents (N = 3,444 of 4,663 eligible) completed the wave six teen survey at approximately age 15. School connectedness was self-reported with four items measuring inclusiveness, closeness, happiness, and safety felt by the adolescent in their school environment. Sexual intercourse and nonconsensual sex were self-reported by the adolescent. Hierarchical regression analyses were conducted examining sexual intercourse, nonconsensual sex, risk factors, and school connectedness. In this sample of adolescents (48% female, 49% Black, 25% Hispanic, ages 14-19), school connectedness appears to reduce boys' risk of nonconsensual sex (OR = 0.29, p < 0.01), and reduce girls' risk of engaging in sexual intercourse (OR = 0.55, p < 0.01). Findings suggest gender differences in the association between school connectedness and sexual practices in adolescents. School connectedness may confer protection for boys' risk of nonconsensual sex, and for girls' risk of engaging in sexual intercourse. Further exploration of the relationship between school connectedness may allow for recommendations into preventative measures for teenage sexual behaviors.

This article reports on the feasibility of testing of the symmetry under reversal in time in a purely leptonic system constituted by positronium atoms using the J-PET detector. The present state of T symmetry tests is discussed with an emphasis on the scarcely explored sector of leptonic systems. Two possible strategies of searching for manifestations of T violation in nonvanishing angular correlations of final state observables in the decay of metastable triplet states of positronium available with J-PET are proposed and discussed. Results of a pilot measurement with J-PET and assessment of its performance in reconstruction of three-photon decays are shown along with an analysis of its impact on the sensitivity of the detector for the determination of T-violation sensitive observables.

The existence of a new force beyond the Standard Model is compelling because it could explain several striking astrophysical observations which fail standard interpretations. We searched for the light vector mediator of this dark force, the U boson, with the KLOE detector at the DAΦNE e+e− collider. Using an integrated luminosity of 1.54 fb−1, we studied the process e+e−→Uγ, with U→e+e−, using radiative return to search for a resonant peak in the dielectron invariant-mass distribution. We did not find evidence for a signal, and set a 90% CL upper limit on the mixing strength between the Standard Model photon and the dark photon, ε2, at 10−6–10−4 in the 5–520 MeV/c2 mass range.

We searched for evidence of a Higgsstrahlung process in a secluded sector, leading to a final state with a dark photon U and a dark Higgs boson h′, with the KLOE detector at DAΦNE. We investigated the case of h′ lighter than U, with U decaying into a muon pair and h′ producing a missing energy signature. We found no evidence of the process and set upper limits to its parameters in the range 2mμ

We have studied the vector to pseudoscalar conversion decay ϕ→ηe+e−, with η→π0π0π0, with the KLOE detector at DAΦNE. The data set of 1.7 fb−1 of e+e− collisions at s∼Mϕ contains a clear conversion decay signal of ∼31,000 events from which we measured a value of BR(ϕ→ηe+e−)=(1.075±0.007±0.038)×10−4. The same sample is used to determine the transition form factor by a fit to the e+e− invariant mass spectrum, obtaining bϕη=(1.28±0.10−0.08+0.09) GeV−2, that improves by a factor of five the precision of the previous measurement and is in good agreement with VMD expectations. Keywords: e+e− collisions, Conversion decay, Transition form factor

The absolute branching ratio of the K+→π+π−π+(γ) decay, inclusive of final-state radiation, has been measured using ∼17 million tagged K+ mesons collected with the KLOE detector at DAΦNE, the Frascati ϕ-factory. The result is:BR(K+→π+π−π+(γ))=0.05565±0.00031stat±0.00025syst a factor ≃ 5 more precise with respect to the previous result. This work completes the program of precision measurements of the dominant kaon branching ratios at KLOE. Keywords: e+e− experiments, Kaon decays

We have searched for a light vector boson U, the possible carrier of a “dark force”, with the KLOE detector at the DAΦNE e+e− collider, motivated by astrophysical evidence for the presence of dark matter in the Universe. Using e+e− collisions collected with an integrated luminosity of 239.3 pb−1, we look for a dimuon mass peak in the reaction e+e−→μ+μ−γ, corresponding to the decay U→μ+μ−. We find no evidence for a U vector boson signal. We set a 90% CL upper limit for the mixing parameter squared between the photon and the U boson of 1.6×10−5 to 8.6×10−7 for the mass region 520