Author: "A. G. Giuffrida" - Searchworks@Jio Institute Digital Library Search Results

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1. P931: PROSPECTIVE OBSERVATIONAL MULTICENTER STUDY OF GAUCHER DISEASE PREVALENCE IN PATIENTS AFFECTED BY MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE

Author: G. Giuffrida, U. Markovic, C. Conticello, D. Nicolosi, V. Calafiore, A. Romano, A. Condorelli, S. Grasso, A. Duminuco, M. Calagna, A. Nardo, C. Riccobene, B. Esposito, U. Consoli, V. Di Giacomo, S. Neri, M. R. Cingari, G. Iaria, V. Innao, M. Spina, J. Gentile, C. Zizzo, G. Duro, and F. Di Raimondo
Subjects: Diseases of the blood and blood-forming organs, RC633-647.5
Published: 2022
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2. Peptide receptor radionuclide therapy for aggressive pituitary tumors: a monocentric experience

Author: G Giuffrida, F Ferraù, R Laudicella, O R Cotta, E Messina, F Granata, F F Angileri, A Vento, A Alibrandi, S Baldari, and S Cannavò
Subjects: pituitary tumors, aggressive pituitary adenomas, peptide receptor radionuclide therapy, PRRT, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract: In aggressive pituitary tumors (PT) showing local invasion or growth/recurrence despite multimodal conventional treatment, temozolomide (TMZ) is considered a further therapeutic option, while little data are available on peptide receptor radionuclide therapy (PRRT). We analyzed PRRT effectiveness, safety and long-term outcome in three patients with aggressive PT, also reviewing the current literature. Patient #1 (F, giant prolactinoma) received five cycles (total dose 37 GBq) of 111In-DTPA-octreotide over 23 months, after unsuccessful surgery and long-term dopamine-agonist treatment. Patient #2 (M, giant prolactinoma) underwent two cycles (12.6 GBq) of 177Lu-DOTATOC after multiple surgeries, radiosurgery and TMZ. In patient #3 (F, non-functioning PT), five cycles (29.8 GBq) of 177Lu-DOTATOC followed five surgeries, radiotherapy and TMZ. Eleven more cases of PRRT-treated aggressive PT emerged from literature. Patient #1 showed tumor shrinkage and visual/neurological amelioration over 8-year follow-up, while the other PTs continued to grow causing blindness and neuro-cognitive disorders (patient #2) or monolateral amaurosis (patient #3). No adverse effects were reported. Including the patients from literature, 4/13 presented tumor shrinkage and clinical/biochemical improvement after PRRT. Response did not correlate with patients’ gender or age, neither with used radionuclide/peptide, but PRRT failure was significantly associated with previous TMZ treatment. Overall, adverse effects occurred only in two patients. PRRT was successful in 1/3 of patients with aggressive PT, and in 4/5 of those not previously treated with TMZ, representing a safe option after unsuccessful multimodal treatment. However, at present, considering the few data, PRRT should be considered only in an experimental setting.
Published: 2019
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3. Recommendations and Protocols for the Use of the Isotope Ratio Infrared Spectrometer (Delta Ray) to Measure Stable Isotopes from CO2: An Application to Volcanic Emissions at Mount Etna and Stromboli (Sicily, Italy)

Author: G. Boudoire, F. Grassa, G. Giuffrida, and M. Liuzzo
Subjects: Geology, QE1-996.5
Abstract: Among major volatiles released from the Earth’s interior, CO2 is an important target for the international community. The interest is keenly motivated by the contribution of CO2 in the Earth’s carbon budget and its role on past, current, and future climate dynamics. In particular, the isotopic signature of CO2 is fundamental to characterize the source of this gas and its evolution up to the atmosphere. The recent development of new laser-based techniques has marked an important milestone for the scientific community by favoring both high-frequency and in situ stable isotope measurements. Among them, the Delta Ray IRIS (Thermo Scientific Inc., Waltham, USA) is one of the most promising instruments thanks to its high precision, its limited interferences with other gaseous species (such as H2S and/or SO2), and its internal calibration procedure. These characteristics and the relative easiness to transport the Delta Ray IRIS have encouraged its use on the field to analyze volcanic CO2 emissions in recent years but often with distinct customized protocols of measurements. In this study, various tests in the laboratory and on the field have been performed to study the dependence of CO2 isotope measurements on analytical, instrumental, and environmental conditions. We emphasize the exceptional ability of the Delta Ray IRIS to perform isotope measurements for a large range of CO2 concentration (200 ppm–100%) thanks to a dilution system and to get a reliable estimation of the real CO2 content from the diluted one. These tests lead to point out major recommendations on the use of Delta Ray IRIS and allow the development of adapted protocols to analyze CO2 emissions like in volcanic environments.
Published: 2020
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4. Identifying phenotypic expansions for congenital diaphragmatic hernia plus ( <scp>CDH</scp> +) using <scp>DECIPHER</scp> data

Author: Amy Hardcastle, Aliska M. Berry, Ian M. Campbell, Xiaonan Zhao, Pengfei Liu, Amanda E. Gerard, Jill A. Rosenfeld, Saumya D. Sisoudiya, Andres Hernandez‐Garcia, Sara Loddo, Silvia Di Tommaso, Antonio Novelli, Maria L. Dentici, Rossella Capolino, Maria C. Digilio, Ludovico Graziani, Cecilie F. Rustad, Katherine Neas, Giovanni B. Ferrero, Alfredo Brusco, Eleonora Di Gregorio, Diana Wellesley, Claire Beneteau, Madeleine Joubert, Kris Van Den Bogaert, Anneleen Boogaerts, Dominic J. McMullan, John Dean, Maria G. Giuffrida, Laura Bernardini, Vinod Varghese, Nora L. Shannon, Rachel E. Harrison, Wayne W. K. Lam, Shane McKee, Peter D. Turnpenny, Trevor Cole, Jenny Morton, Jacqueline Eason, Marilyn C. Jones, Rebecca Hall, Michael Wright, Karen Horridge, Chad A. Shaw, Wendy K. Chung, and Daryl A. Scott
Subjects: DNA Copy Number Variations, Diaphragm, USP9X, CREBBP, DECIPHER database, SMARCA4, UBA2, congenital diaphragmatic hernia, Mice, Genetics, Animals, Hernias, Diaphragmatic, Congenital, Genetics (clinical)
Abstract: Congenital diaphragmatic hernia (CDH) can occur in isolation or in conjunction with other birth defects (CDH+). A molecular etiology can only be identified in a subset of CDH cases. This is due, in part, to an incomplete understanding of the genes that contribute to diaphragm development. Here, we used clinical and molecular data from 36 individuals with CDH+ who are cataloged in the DECIPHER database to identify genes that may play a role in diaphragm development and to discover new phenotypic expansions. Among this group, we identified individuals who carried putatively deleterious sequence or copy number variants affecting CREBBP, SMARCA4, UBA2, and USP9X. The role of these genes in diaphragm development was supported by their expression in the developing mouse diaphragm, their similarity to known CDH genes using data from a previously published and validated machine learning algorithm, and/or the presence of CDH in other individuals with their associated genetic disorders. Our results demonstrate how data from DECIPHER, and other public databases, can be used to identify new phenotypic expansions and suggest that CREBBP, SMARCA4, UBA2, and USP9X play a role in diaphragm development.
Published: 2022

5. Global Cushing’s disease epidemiology: a systematic review and meta-analysis of observational studies

Author: G. Giuffrida, S. Crisafulli, F. Ferraù, A. Fontana, Y. Alessi, F. Calapai, M. Ragonese, N. Luxi, S. Cannavò, and G. Trifirò
Subjects: Endocrinology, Endocrinology, Diabetes and Metabolism
Published: 2022

6. Gaia Early Data Release 3 The Gaia Catalogue of Nearby Stars

Author: Zoltan Balog, G. Tauran, Vincenzo Ripepi, Gerry Gilmore, M. Barros, Łukasz Wyrzykowski, Alberto Cellino, E. Poggio, P. Gavras, Simchon Faigler, Marc Audard, C. Nicolas, M. Vaillant, A. Mora, Paolo Tanga, Silvio Leccia, Despina Hatzidimitriou, A. Dapergolas, Eva Sciacca, Alberto Krone-Martins, N. Cheek, M. Hauser, Ulrike Heiter, S. Managau, L. Rohrbasser, Mathias Schultheis, E. Utrilla, Minia Manteiga, Marcella Marconi, Xavier Luri, F. De Angeli, Shay Zucker, Paolo Giacobbe, J. Juaristi Campillo, H. I. Siddiqui, J. Torra, F. X. Pineau, Roy Gomel, Thierry Morel, T. Cornez, Eric Gosset, Mario Gai, Jose M Hernandez, G. Giuffrida, A. de Torres, Laszlo Szabados, S. Ragaini, E. van Dillen, D. Semeux, Leanne P. Guy, R. Drimmel, L. M. Sarro, S. Voutsinas, Johannes Sahlmann, Damien Ségransan, S. Liao, Derek W. Morris, Jan Rybizki, André Moitinho, T. Roegiers, Bengt Edvardsson, Tristan Cantat-Gaudin, Martin Altmann, C. Turon, Laurent Chemin, K. Janßen, D. Garabato, Alejandra Recio-Blanco, Michał Pawlak, Lorenzo Rimoldini, Sergei A. Klioner, F. Torra, Carine Babusiaux, Alfred Castro-Ginard, G. Plum, Mariateresa Crosta, Iain A. Steele, A. Yoldas, Alex Lobel, J.-L. Bassilana, Harry Enke, Rosanna Sordo, Francesca Fragkoudi, F. De Luise, M. Bernet, Alessandro Sozzetti, M. Kontizas, Roberto Molinaro, C. Diener, S. Regibo, D. Barbato, T. Pauwels, R. E. de Souza, C. Fabricius, D. Souami, L. Martin Polo, M. Ramos-Lerate, Douglas J. Marshall, A. G. Butkevich, P. Madrero Pardo, P. Re Fiorentin, J. F. Le Campion, Jérôme Berthier, N. Tonello, Ummi Abbas, Y. Lebreton, M. Biermann, D. Munoz, N. Brouillet, David Teyssier, O. Vanel, P. A. Palicio, A. Jean-Antoine Piccolo, A. F. Lanza, Jesus Salgado, E. del Pozo, Antti Penttilä, R. Geyer, Ramachrisna Teixeira, L. Chaoul, Mike Smith, Rossella Cancelliere, J. M. Martín-Fleitas, D. Baines, M. Romero-Gómez, E. Anglada Varela, E. Livanou, X. Peñalosa Esteller, S. Diakite, Alberto Vecchiato, Thomas Wevers, Daniel Hestroffer, Sebastian L. Hidalgo, M. David, Angela Bragaglia, J. De Ridder, Mark Taylor, Roberto Morbidelli, A. Sagristà Sellés, Nigel Hambly, Arnaud Siebert, R. L. Smart, P. Burgess, Y. Le Fustec, Alessandro Bressan, H. Steidelmüller, Alberto Riva, H. E. Huckle, Morgan Fouesneau, N. Bauchet, P. Osborne, S. Marinoni, Krzysztof A. Rybicki, A. Masip, Laia Casamiquela, R. Messineo, A. Garofalo, Antonella Vallenari, R. Mor, Sahar Shahaf, P. de Laverny, G. Sadowski, Peter G. Jonker, A. Kochoska, F. Taris, A. F. Mulone, M. Ajaj, C. Ducourant, T. A. Lister, F. A. Jansen, Ruth Carballo, J. M. Carrasco, Tatiana Muraveva, W. van Reeven, P. Sartoretti, Jordi Portell, Andreas Korn, E. Salguero, Ana Ulla, P. Di Matteo, Coryn A. L. Bailer-Jones, J. Bakker, F. Riclet, G. Altavilla, Ulrich Bastian, P. Esquej, R. Buzzi, M. Segol, A. C. Lanzafame, L. Balaguer-Núñez, Beatrice Bucciarelli, C. Panem, E. Balbinot, T. Carlucci, Davide Massari, P. de Teodoro, Sébastien Lambert, M. I. Carnerero, Amina Helmi, F. Solitro, C. Robin, Carlos Dafonte, Tsevi Mazeh, A. Panahi, C. Fabre, Sergi Blanco-Cuaresma, Deborah Busonero, Maroussia Roelens, O. Marchal, Tomaz Zwitter, B. Holl, G. Holland, William Thuillot, Michael Davidson, E. Licata, Michele Bellazzini, Teresa Antoja, E. Szegedi-Elek, Francesca Figueras, Eric Slezak, Sergio Messina, N. Samaras, E. Poujoulet, Mark Cropper, A. Burlacu, R. Blomme, Elmé Breedt, Annie C. Robin, H. E. Delgado, Z. Kostrzewa-Rutkowska, Georges Kordopatis, Conny Aerts, L. Noval, Daniel Michalik, P. J. Richards, L. Karbevska, Grigori Fedorets, Maria Süveges, F. Crifo, J. Guiraud, D. Eappachen, K. Kruszyńska, Gisella Clementini, P. Yvard, Carme Jordi, L. Bramante, G. Busso, P. David, E. Fraile, Ugo Becciani, A. Lorca, Sanjeev Khanna, Alex Bombrun, Isabella Pagano, C. Dolding, A. M. Piersimoni, Paolo Montegriffo, A. Abreu Aramburu, Anthony G. A. Brown, Simon Hodgkin, Ennio Poretti, M. Fabrizio, I. Gonzalez-Santamaria, N. A. Walton, P. Panuzzo, Benoit Carry, Raphael Guerra, J. J. González-Vidal, T. Lebzelter, Nami Mowlavi, C. Barache, M. M. S. Marcos Santos, S. Cowell, Marco Castellani, J. J. Aguado, N. R. Millar, A. Baudesson-Stella, N. Leclerc, S. Bartolomé, J. Álvarez Cid-Fuentes, F. van Leeuwen, S. Bouquillon, Uwe Lammers, D. W. Evans, L. Eyer, M. van Leeuwen, A. Guerrier, J. González-Núñez, H. E. P. Lindstrøm, Miguel García-Torres, Ilaria Musella, L. Palaversa, W. Roux, W. Löffler, J.-B. Delisle, Dimitri Pourbaix, Timo Prusti, J. Osinde, M. Riello, G. Orrù, C. Crowley, Alessandra Mastrobuono-Battisti, Hector Canovas, D. L. Harrison, Y. Lasne, E. F. del Peloso, Laurent Galluccio, N. Hładczuk, T. Boch, Martin A. Barstow, László Molnár, Aldo Dell'Oro, C. Pagani, Krzysztof Nienartowicz, Stefano Bertone, Patrick Charlot, Eduard Masana, Elisabetta Caffau, N. Robichon, Luciana Bianchi, Federica Spoto, Felix Franke, J. L. Halbwachs, R. Gutiérrez-Sánchez, L. Pulone, Yassine Damerdji, Frédéric Arenou, Richard I. Anderson, Elena Pancino, David Hobbs, P. Castro Sampol, Yves Fremat, Pierre Kervella, C. Zurbach, Sofia Randich, Robert G. Mann, J. C. Segovia, Diego Bossini, D. Katz, Nicholas Rowell, P. Ramos, E. Racero, G. Gracia-Abril, R. Santoveña, R. Haigron, N. Unger, Enrique Solano, S. G. Baker, W. J. Cooper, F. Royer, S. Accart, George M. Seabroke, João Alves, Emese Plachy, Thomas Hilger, Pedro García-Lario, Gérard Jasniewicz, Kevin Benson, Christos Siopis, J. Souchay, Agnes Fienga, Giovanni Comoretto, F. Julbe, A. Hutton, Pierre Fernique, Céline Reylé, F. Pailler, Stefan Jordan, J. H. J. de Bruijne, C. A. Stephenson, E. Gerlach, Elisa Distefano, Karri Muinonen, Y. Viala, H. Zhao, L. Siltala, C. P. Murphy, Maria-Rosa L. Cioni, Andrea Chiavassa, D. Molina, J. Fernández-Hernández, G. Jevardat de Fombelle, Federico Marocco, Nicoletta Sanna, Alexey Mints, Juan Zorec, Ángel Gómez, I. Bellas-Velidis, M. G. Lattanzi, C. M. Raiteri, E. Brugaletta, Mikael Granvik, O. L. Creevey, Guy Rixon, Francois Mignard, P. M. Marrese, M. A. Álvarez, Caroline Soubiran, Rene Andrae, C. Ordénovic, A. Delgado, V. Sanchez Gimenez, J. Castañeda, D. Vicente, R. De March, A. Garcia-Gutierrez, M. Weiler, F. Thévenin, Lennart Lindegren, Isabelle Lecoeur-Taïbi, Jon Marchant, Monica Rainer, Alessandro Spagna, Andrej Prsa, M. Sarasso, Nicolas Rambaux, Paul J. McMillan, Ludovic Delchambre, M. Garcia-Reinaldos, M. Haywood, C. Fouron, S. Girona, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Universidad de Barcelona, Xunta de Galicia, Generalitat de Catalunya, INAF - Osservatorio Astrofisico di Torino (OATo), Istituto Nazionale di Astrofisica (INAF), Univers, Transport, Interfaces, Nanostructures, Atmosphère et environnement, Molécules (UMR 6213) (UTINAM), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Centre National d'Études Spatiales [Toulouse] (CNES)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), Galaxies, Etoiles, Physique, Instrumentation (GEPI), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Joseph Louis LAGRANGE (LAGRANGE), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Centre National d'Études Spatiales [Toulouse] (CNES), Laboratoire d'Astrophysique de Bordeaux [Pessac] (LAB), Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Astronomische Rechen-Institut [Heidelberg] (ARI), Zentrum für Astronomie der Universität Heidelberg (ZAH), Universität Heidelberg [Heidelberg]-Universität Heidelberg [Heidelberg], Systèmes de Référence Temps Espace (SYRTE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut de Mécanique Céleste et de Calcul des Ephémérides (IMCCE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Lille-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Observatoire astronomique de Strasbourg (ObAS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Mésocentre de calcul (MESOCENTRE), Université de Franche-Comté (UFC), Centre de Données Astronomiques de Strasbourg, Partenaires INRAE, Géoazur (GEOAZUR 7329), Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Laboratoire Univers et Particules de Montpellier (LUPM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut de Physique de Rennes (IPR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), THALES, Université de Namur [Namur] (UNamur), Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France -Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France, Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Universität Heidelberg [Heidelberg] = Heidelberg University-Universität Heidelberg [Heidelberg] = Heidelberg University, Université de Strasbourg (UNISTRA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics (LESIA), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), THALES [France], Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Universidad de Cantabria, Gaia Collaboration, Planetary-system research, Department of Physics, Particle Physics and Astrophysics, Astronomy, and ITA
Subjects: trigonometric parallaxes, Solar neighborhood, Stars: luminosity function, mass function, Astronomy, Astrophysics, 01 natural sciences, luminosity function, mass function [Stars], Astronomi, astrofysik och kosmologi, luminosity: mass function [Stars], Astronomy, Astrophysics and Cosmology, MAIN-SEQUENCE, Hertzsprung-Russell-diagram, 010303 astronomy & astrophysics, Stars:low-mass brown-dwarfs, wide binaries, Physics, education.field_of_study, north galactic pole, Astrophysics::Instrumentation and Methods for Astrophysics, Astrometry, BROWN DWARF, Astrophysics - Solar and Stellar Astrophysics, mass function, NORTH GALACTIC POLE, Physical Sciences, symbols, CIRCULAR-VELOCITY CURVE, Halo, astro-ph.SR, Hertzsprung–Russell diagram, stars: luminosity function, astro-ph.GA, Posterior probability, Population, main-sequence, Luminosity-Function, FOS: Physical sciences, Mass-Function, Astronomy & Astrophysics, Computer Science::Digital Libraries, Photometry (optics), DWARF LUMINOSITY-FUNCTION, dwarf luminosity-function, sky-survey, symbols.namesake, Settore FIS/05 - Astronomia e Astrofisica, luminosity function [stars], low-mass [Stars], 0103 physical sciences, Stars: luminosity: mass function, Stars: low-mass, WHITE-DWARFS, education, Solar and Stellar Astrophysics (astro-ph.SR), brown dwarf, catalogs, astrometry, Hertzsprung-Russell and C-M diagrams, stars: low-mass, solar neighborhood, Astrophysics - Astrophysics of Galaxies, SKY-SURVEY, white-dwarfs, Science & Technology, 010308 nuclear & particles physics, Luminosity function, White dwarf, TRIGONOMETRIC PARALLAXES, Astronomy and Astrophysics, Low-mass, 115 Astronomy, Space science, WIDE BINARIES, Stars, Physics::History of Physics, 13. Climate action, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), solar-neighborhood, Catalogs, circular-velocity curve, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: Aims. We produce a clean and well-characterised catalogue of objects within 100 pc of the Sun from the Gaia Early Data Release 3. We characterise the catalogue through comparisons to the full data release, external catalogues, and simulations. We carry out a first analysis of the science that is possible with this sample to demonstrate its potential and best practices for its use., Methods. Theselection of objects within 100 pc from the full catalogue used selected training sets, machine-learning procedures, astrometric quantities, and solution quality indicators to determine a probability that the astrometric solution is reliable. The training set construction exploited the astrometric data, quality flags, and external photometry. For all candidates we calculated distance posterior probability densities using Bayesian procedures and mock catalogues to define priors. Any object with reliable astrometry and a non-zero probability of being within 100 pc is included in the catalogue., Results. We have produced a catalogue of 331 312 objects that we estimate contains at least 92% of stars of stellar type M9 within 100 pc of the Sun. We estimate that 9% of the stars in this catalogue probably lie outside 100 pc, but when the distance probability function is used, a correct treatment of this contamination is possible. We produced luminosity functions with a high signal-to-noise ratio for the main-sequence stars, giants, and white dwarfs. We examined in detail the Hyades cluster, the white dwarf population, and wide-binary systems and produced candidate lists for all three samples. We detected local manifestations of several streams, superclusters, and halo objects, in which we identified 12 members of Gaia Enceladus. We present the first direct parallaxes of five objects in multiple systems within 10 pc of the Sun., Conclusions. We provide the community with a large, well-characterised catalogue of objects in the solar neighbourhood. This is a primary benchmark for measuring and understanding fundamental parameters and descriptive functions in astronomy.
Published: 2021

7. Bromine monoxide / sulphur dioxide ratios in relation to volcanological observations at Mt. Etna 2006–2009

Author: G. Giuffrida and N. Bobrowski
Subjects: Geology, QE1-996.5, Stratigraphy, QE640-699
Abstract: Over a 3-yr period, from 2006 to 2009, frequent scattered sunlight DOAS measurements were conducted at Mt. Etna at a distance of around 6 km downwind from the summit craters. During the same period and in addition to these measurements, volcanic observations were made by regularly visiting various parts of Mt. Etna. Here, results from these measurements and observations are presented and their relation is discussed. The focus of the investigation is the bromine monoxide/sulphur dioxide (BrO / SO2) ratio, and its variability in relation to volcanic processes. That the halogen/sulphur ratio can serve as a precursor or indicator for the onset of eruptive activity was already proposed by earlier works (e.g. Noguchi and Kamiya 1963; Menyailov, 1975; Pennisi and Cloarec, 1998; Aiuppa et al., 2002). However, there is still a limited understanding today because of the complexity with which halogens are released, depending on magma composition and degassing conditions. Our understanding of these processes is far from complete, for example of the rate and mechanism of bubble nucleation, growth and ascent in silicate melts (Carroll and Holloway, 1994), the halogen vapour-melt partitioning and the volatile diffusivity in the melt (Aiuppa et al., 2009). With this study we aim to add one more piece to the puzzle of what halogen/sulphur ratios might tell about volcanic activities. Our data set shows an increase of the BrO / SO2 ratio several weeks prior to an eruption, followed by a decline before and during the initial phase of eruptive activities. Towards the end of activity or shortly thereafter, the ratio increases to baseline values again and remains more or less constant during quiet phases. To explain the observed evolution of the BrO / SO2 ratio, a first empirical model is proposed. This model suggests that bromine, unlike chlorine and fluorine, is less soluble in the magmatic melt than sulphur. By using the DOAS method to determine SO2, we actually observe most of the emitted sulphur of Mt.~Etna. Regarding bromine, however, we are aware that by determining only the bromine monoxide (BrO) radical we might just observe a small or even a variable fraction of the total emitted bromine, which is most probable originally in the form of HBr. Therefore, we present first studies to justify the assumption that, despite the disadvantage just mentioned, the BrO / SO2 ratio can nevertheless serve as a new parameter to indicate the state of a volcano, when measurements are conducted under certain, but rather convenient, conditions.
Published: 2012
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8. Global Cushing's disease epidemiology: a systematic review and meta-analysis of observational studies

Author: G, Giuffrida, S, Crisafulli, F, Ferraù, A, Fontana, Y, Alessi, F, Calapai, M, Ragonese, N, Luxi, S, Cannavò, and G, Trifirò
Subjects: Adenoma, ACTH-Secreting Pituitary Adenoma, Incidence, Prevalence, Humans, Pituitary ACTH Hypersecretion
Abstract: Cushing's disease (CD), 70% of endogenous hypercortisolism cases, is a rare disease caused by adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas. To date, no systematic reviews and meta-analyses on its global epidemiology have been published. We provide a systematic review and meta-analysis of CD global epidemiology, also evaluating the quality of study reporting for the identified studies.MEDLINE and EMBASE databases were searched for studies on CD epidemiology from inception until November 30th, 2020, including original observational studies in English about CD prevalence and/or incidence for well-defined geographic areas. Two reviewers independently extracted data and assessed reporting quality. CD prevalence/incidence pooled estimates were derived from a random-effects meta-analysis. Reporting quality was assessed using a STrengthening the Reporting of OBservational studies in Epidemiology (STROBE) checklist adapted for observational studies on rare diseases, heterogeneity using the Cochran's Q-test and its derived measure of inconsistency (IThirteen studies were included. The pooled CD prevalence was 2.2 [95% CI 1.1-4.8] per 100,000, while the incidence rate was 0.24 [95% CI 0.15-0.33] per 100,000 person-years. For both parameters, considerable between-studies heterogeneity was found (IOverall, our systematic meta-analysis demonstrated CD epidemiology to be similarly reported across different areas of the world, with some exceptions regarding regional differences or observation period intervals. Keeping into account the methodological differences between each paper, large-scale studies on CD epidemiology are warranted. Setting up national specific registries, based on standardized diagnostic and clinical parameters, with clearly defined selection and analysis criteria, and a strong cooperation between the scientific national societies for endocrinology is crucial to exclude other causes of variability (i.e. geographical differences due to other factors like (epi)genetic changes), and to support public health decision making.
Published: 2021

9. SP5.2.6 Adrenal Incidentalomas in Living Kidney Donors: A Dilemma?

Author: G. Giuffrida, Zia Moinuddin, David van Dellen, Chloe Theodorou, and Titus Augustine
Subjects: Dilemma, Pediatrics, medicine.medical_specialty, Kidney, medicine.anatomical_structure, business.industry, medicine, Surgery, business
Abstract: Aims During donor multi-detector CT angiogram (MDCTA), incidental findings occur, commonly adrenal incidentalomas (AIs). These are usually benign and non-functional with an estimated incidence of 4%.1 These potentially limit organ donation due to the need to exclude malignancy. There is no consensus on the management of donors with AIs.1,2 This study aims to explore the incidence and clinical course of AI’s in living kidney donors. Methods We performed a single-centre, retrospective study on all prospective living kidney donors between November 2000 and September 2020. Patients with adrenal lesions during work-up were identified and further information was collected from electronic patient records. Results Six (1.09%) of the 546 donors during that period had an AI. All were small ( Conclusion The incidence of adrenal pathology in living donors is low and largely benign. These patients should not be excluded from donation. Such patients could benefit from open discussion regarding simultaneous adrenalectomy vs conservative management.
Published: 2021

10. Olive cake, citrus pulp and wheat straw silage as an ingredient in lamb diets: 2. Effects on meat quality

Author: L.G. Chies, M. Scerra, G. Giuffrida, P. Caparra, and F. Foti
Subjects: Olive cake, citrus pulp, lamb, meat quality., Animal culture, SF1-1100
Abstract: In the Mediterranean area, the use of some agricultural by-products, difficult to be eliminated, in the feeding of animals, represents a key element for the valorization of bioenergetic resources. Among the agricultural by-products which may be found at a low price in our area, the olive cake and the citrus pulp of orange have awaked great interest...
Published: 2011
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11. The Galactic Anticentre

Author: Vincenzo Ripepi, A. de Torres, Annie C. Robin, Mariateresa Crosta, C. Diener, L. Noval, Daniel Michalik, P. J. Richards, L. Karbevska, K. Kruszyńska, E. Fraile, André Moitinho, Michał Pawlak, P. Panuzzo, M. Riello, Benoit Carry, A. Yoldas, Harry Enke, N. Tonello, P. Gavras, M. Vaillant, Rosanna Sordo, E. del Pozo, Lorenzo Rimoldini, M. Bernet, G. Orrù, W. van Reeven, J. M. Martín-Fleitas, S. Diakite, P. Burgess, P. Osborne, Derek W. Morris, M. I. Carnerero, Amina Helmi, Mike Smith, Iain A. Steele, Alessandro Sozzetti, M. Kontizas, A. Sagristà Sellés, Roberto Molinaro, B. Holl, D. Baines, D. Molina, J. Fernández-Hernández, S. Marinoni, Michele Bellazzini, Maria Süveges, Teresa Antoja, D. Barbato, Uwe Lammers, Isabella Pagano, Davide Massari, G. Plum, P. Ramos, G. Jevardat de Fombelle, M. Biermann, C. Crowley, Mathias Schultheis, D. W. Evans, P. A. Palicio, Paolo Montegriffo, Ramachrisna Teixeira, R. Blomme, Elmé Breedt, T. A. Lister, F. A. Jansen, Ruth Carballo, Marcella Marconi, A. Abreu Aramburu, J. M. Carrasco, F. Royer, S. Accart, A. Burlacu, S. Regibo, Andrej Prsa, M. Sarasso, Nicolas Rambaux, A. F. Mulone, Ana Ulla, Eric Gosset, Alessandra Mastrobuono-Battisti, George M. Seabroke, H. E. Delgado, Federico Marocco, C. Nicolas, T. Lebzelter, Nami Mowlavi, C. Barache, Nicoletta Sanna, G. Gracia-Abril, R. Santoveña, R. Haigron, N. Unger, Silvio Leccia, A. Jean-Antoine Piccolo, A. F. Lanza, Alberto Vecchiato, Thomas Wevers, F. Figueras, G. Busso, C. Fabre, P. Di Matteo, F. Riclet, F. Solitro, Eric Slezak, N. Samaras, João Alves, Emese Plachy, Timo Prusti, F. van Leeuwen, J. Osinde, O. Marchal, M. Ajaj, C. Ducourant, Tatiana Muraveva, Shay Zucker, H. Steidelmüller, Alberto Riva, D. Semeux, N. Cheek, Laurent Galluccio, Martin A. Barstow, Alex Bombrun, S. Liao, M. van Leeuwen, R. E. de Souza, P. de Laverny, T. Roegiers, Paul J. McMillan, G. Holland, Alexey Mints, G. Giuffrida, L. M. Sarro, Juan Zorec, G. Sadowski, P. Yvard, Carme Jordi, J. L. Halbwachs, Laurent Chemin, Ludovic Delchambre, M. Garcia-Reinaldos, Ugo Becciani, Diego Bossini, Ángel Gómez, Sergi Blanco-Cuaresma, Rossella Cancelliere, C. Fabricius, J. De Ridder, L. Eyer, L. Pulone, Simon Hodgkin, Ennio Poretti, F. De Angeli, M. Haywood, E. Anglada Varela, Antonella Vallenari, F. X. Pineau, D. Garabato, A. Guerrier, H. E. P. Lindstrøm, Thomas Hilger, I. Bellas-Velidis, Frédéric Arenou, Paolo Giacobbe, Ilaria Musella, Tristan Cantat-Gaudin, L. Palaversa, Pedro García-Lario, David Hobbs, C. Turon, E. Balbinot, P. de Teodoro, Sébastien Lambert, D. Katz, Angela Bragaglia, Anthony G. A. Brown, Paolo Tanga, P. Castro Sampol, J. C. Segovia, Alejandra Recio-Blanco, Yves Fremat, Jon Marchant, Jose M Hernandez, S. Ragaini, Sofia Randich, P. Re Fiorentin, J. F. Le Campion, Gisella Clementini, M. Segol, P. David, R. Drimmel, F. Crifo, J. Guiraud, M. David, R. L. Smart, M. Fabrizio, I. Gonzalez-Santamaria, D. Eappachen, M. G. Lattanzi, Miguel García-Torres, Andreas Korn, S. Voutsinas, László Molnár, Simchon Faigler, A. Mora, Nicholas Rowell, Antti Penttilä, R. Geyer, Sanjeev Khanna, Aldo Dell'Oro, H. E. Huckle, C. Dolding, N. Leclerc, Monica Rainer, R. Mor, J. Bakker, Maroussia Roelens, Douglas J. Marshall, A. G. Butkevich, Nigel Hambly, A. Masip, Laia Casamiquela, R. Messineo, Martin Altmann, A. M. Piersimoni, Alessandro Spagna, Gerry Gilmore, Stefano Bertone, Patrick Charlot, O. Vanel, Daniel Hestroffer, Marco Castellani, Sebastian L. Hidalgo, W. Roux, Łukasz Wyrzykowski, Krzysztof A. Rybicki, M. M. S. Marcos Santos, Raphael Guerra, Alberto Cellino, E. Poggio, Gérard Jasniewicz, J. J. González-Vidal, S. Cowell, Peter G. Jonker, C. M. Raiteri, S. Bartolomé, J. Álvarez Cid-Fuentes, Elisabetta Caffau, J. J. Aguado, N. R. Millar, Ulrike Heiter, Federica Spoto, Felix Franke, A. Baudesson-Stella, M. Barros, Tsevi Mazeh, A. Panahi, E. Brugaletta, R. Buzzi, Elena Pancino, G. Altavilla, E. Racero, Enrique Solano, Mikael Granvik, Minia Manteiga, C. Robin, Tomaz Zwitter, Deborah Busonero, Alberto Krone-Martins, Marc Audard, Kevin Benson, Christos Siopis, L. Balaguer-Núñez, C. A. L. Bailer-Jones, E. Poujoulet, O. L. Creevey, E. Szegedi-Elek, C. Fouron, Michael Davidson, E. Licata, Despina Hatzidimitriou, Mark Cropper, Z. Kostrzewa-Rutkowska, S. Managau, A. Dapergolas, Sergio Messina, Laszlo Szabados, H. I. Siddiqui, W. Löffler, Mario Gai, J.-B. Delisle, Leanne P. Guy, S. G. Baker, W. J. Cooper, Alfred Castro-Ginard, Conny Aerts, A. Lorca, Xavier Luri, Damien Ségransan, Grigori Fedorets, A. Garofalo, J. Juaristi Campillo, F. De Luise, F. Pailler, F. Taris, L. Bramante, Thierry Morel, T. Cornez, L. Martin Polo, M. Ramos-Lerate, Jordi Portell, E. Salguero, Sergei A. Klioner, K. Janßen, Ulrich Bastian, Stefan Jordan, P. Esquej, A. C. Lanzafame, Beatrice Bucciarelli, C. Panem, Y. Lebreton, Carlos Dafonte, S. Girona, D. Munoz, Dimitri Pourbaix, William Thuillot, J. H. J. de Bruijne, N. Brouillet, L. Chaoul, F. Torra, Alex Lobel, J.-L. Bassilana, Francesca Fragkoudi, M. Romero-Gómez, C. A. Stephenson, T. Pauwels, Eva Sciacca, Alessandro Bressan, Morgan Fouesneau, E. Livanou, E. Gerlach, X. Peñalosa Esteller, Roberto Morbidelli, L. Rohrbasser, Johannes Sahlmann, Elisa Distefano, P. Sartoretti, Karri Muinonen, Zoltan Balog, Y. Viala, J. Torra, H. Zhao, L. Siltala, G. Tauran, D. Souami, P. Madrero Pardo, David Teyssier, Jesus Salgado, J. Souchay, C. P. Murphy, Maria-Rosa L. Cioni, N. A. Walton, S. Bouquillon, Andrea Chiavassa, Agnes Fienga, Giovanni Comoretto, F. Julbe, A. Hutton, Yassine Damerdji, Richard I. Anderson, Pierre Fernique, Céline Reylé, M. Hauser, E. Utrilla, Pierre Kervella, C. Zurbach, Robert G. Mann, Ummi Abbas, Hector Canovas, D. L. Harrison, Y. Lasne, Mark Taylor, Y. Le Fustec, E. F. del Peloso, N. Bauchet, E. van Dillen, Jan Rybizki, N. Hładczuk, T. Boch, J. González-Núñez, Carine Babusiaux, C. Pagani, Krzysztof Nienartowicz, Eduard Masana, G. Kordopatis, N. Robichon, Luciana Bianchi, R. Gutiérrez-Sánchez, Arnaud Siebert, A. Kochoska, T. Carlucci, Jérôme Berthier, J. Castañeda, D. Vicente, R. De March, A. Garcia-Gutierrez, M. Weiler, F. Thévenin, Lennart Lindegren, Isabelle Lecoeur-Taïbi, Guy Rixon, Francois Mignard, P. M. Marrese, M. A. Álvarez, Caroline Soubiran, Rene Andrae, C. Ordénovic, A. Delgado, V. Sanchez Gimenez, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Universidad de Barcelona, Xunta de Galicia, European Commission, Centros de Excelencia Severo Ochoa, BARCELONA SUPERCOMPUTING CENTER (BSC), SEV2015-0493, Krone Martins, A. [0000-0002-2308-6623], McMillan, P. [0000-0002-8861-2620], Carrasco Martínez, J. P. [0000-0002-3029-5853], Sozzetti, A. [0000-0002-7504-365X], Unidad de Excelencia Científica María de Maeztu Centro de Astrobiología del Instituto Nacional de Técnica Aeroespacial y CSIC, MINECO/ICTI2013-2016/MDM-2014-0369, Centrode Excelencia Científica Instituto de Ciencias del Cosmos Universidad de Barcelona, MINECO/ICTI2013-2016/SEV2015-0493, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), National Natural Science Foundation of China (NSFC), Estonian Ministry of Education and Research, Centre National D'Etudes Spatiales (CNES), Agence Nationale de la Recherche (ANR), Centre National de la Recherche Scientifique (CNRS), European Commission (EC), European Research Council (ERC), Institut des Sciences de l'Univers (INSU), Institut National Polytechnique (INP), Institut National de Physique nucleaire et de Physique des Particules (IN2P3), Deutsches Zentrum für Luft- und Raumfahrt (DLR), Hungarian Academy of Sciences, Hungarian National Research, Development, and Innovation Office (NKFIH), Science Foundation Ireland (SFI), Israel Science Foundation (ISF), Agenzia Spaziale Italiana (ASI), Italian Istituto Nazionale di Astrofisica (INAF), Netherlands Organisation for Scientific Research (NWO), Polish National Science Centre, Ministry of Science and Higher Education (MNiSW), Fundacao para a Ciencia e a Tecnologia (FCT), Slovenian Research Agency, Agencia Estatal de Investigación (AEI), Generalitat de Catalunya, United Kingdom Science and Technology Facilities Council (STFC), United Kingdom Space Agency (UKSA), Gaia Collaboration, Universidad de Cantabria, Astronomy, Kapteyn Astronomical Institute, Institut de Ciencies del Cosmos (ICCUB), Universitat de Barcelona (UB), Joseph Louis LAGRANGE (LAGRANGE), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Kapteyn Astronomical Institute [Groningen], University of Groningen [Groningen], INAF - Osservatorio Astronomico di Padova (OAPD), Istituto Nazionale di Astrofisica (INAF), Institut de recherches sur la catalyse et l'environnement de Lyon (IRCELYON), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), M2A 2021, Laboratoire d'Astrophysique de Bordeaux [Pessac] (LAB), Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut de Physique de Rennes (IPR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Planetary-system research, Department of Physics, Particle Physics and Astrophysics, Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics (LESIA), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), Université Nice Sophia Antipolis (... - 2019) (UNS), and Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)
Subjects: trigonometric parallaxes, SOLAR NEIGHBORHOOD, Astronomy, SAGITTARIUS DWARF GALAXY, Astrophysics, 01 natural sciences, sagittarius dwarf galaxy, 010303 astronomy & astrophysics, Physics, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], solar neighborhood, Astrophysics::Instrumentation and Methods for Astrophysics, Astrometry, Gelexy: kinematics and dynamics, Kinematics and Dynamics, Open clusters and asssociations: individual: Berkeley 29, sky survey, Disk, Physical Sciences, kinematics and dynamics [Gelexy], old open clusters, MILKY-WAY, Astrophysics::Earth and Planetary Astrophysics, open clusters and associations: individual: Berkeley 29, Galaxy: kinematics and dynamics, disk [Galaxy], individual: Berkeley 29 [open clusters and associations], Astrometria, Berkeley 29, EXPLORING HALO SUBSTRUCTURE, LOCAL KINEMATICS, Milky Way, FOS: Physical sciences, Open Clusters and Associations, Individual, exploring halo substructure, Astrophysics::Cosmology and Extragalactic Astrophysics, Astronomy & Astrophysics, Computer Science::Digital Libraries, stellar structure, Galaxy: disk, Open clusters and associations: individual: Saurer 1, Galactic halo, Halo, Settore FIS/05 - Astronomia e Astrofisica, individual: Berkeley 29 [Open clusters and asssociations], 0103 physical sciences, distances [stars], halo [Galaxy], Disc, Stars: distances, milky-way, Saurer 1, Astrophysics::Galaxy Astrophysics, canis-major, Science & Technology, 010308 nuclear & particles physics, TRIGONOMETRIC PARALLAXES, Galaxy: halo, stars: distances, open clusters and associations: individual: Saurer 1, Astrophysics - Astrophysics of Galaxies, Astronomy and Astrophysics, Galactic plane, kinematics and dynamics [Galaxy], 115 Astronomy, Space science, CANIS-MAJOR, Stars, Galaxy, Physics::History of Physics, Estels, individual: Saurer 1 [open clusters and associations], Distances, local kinematics, OLD OPEN CLUSTERS, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), SKY SURVEY, Open cluster, STELLAR STRUCTURE
Abstract: Aims. We aim to demonstrate the scientific potential of the Gaia Early Data Release 3 (EDR3) for the study of different aspects of the Milky Way structure and evolution and we provide, at the same time, a description of several practical aspects of the data and examples of their usage., Methods. We used astrometric positions, proper motions, parallaxes, and photometry from EDR3 to select different populations and components and to calculate the distances and velocities in the direction of the anticentre. In this direction, the Gaia astrometric data alone enable the calculation of the vertical and azimuthal velocities; also, the extinction is relatively low compared to other directions in the Galactic plane. We then explore the disturbances of the current disc, the spatial and kinematical distributions of early accreted versus in situ stars, the structures in the outer parts of the disc, and the orbits of open clusters Berkeley 29 and Saurer 1., Results. With the improved astrometry and photometry of EDR3, we find that: (i) the dynamics of the Galactic disc are very complex with oscillations in the median rotation and vertical velocities as a function of radius, vertical asymmetries, and new correlations, including a bimodality with disc stars with large angular momentum moving vertically upwards from below the plane, and disc stars with slightly lower angular momentum moving preferentially downwards; (ii) we resolve the kinematic substructure (diagonal ridges) in the outer parts of the disc for the first time; (iii) the red sequence that has been associated with the proto-Galactic disc that was present at the time of the merger with Gaia-Enceladus-Sausage is currently radially concentrated up to around 14 kpc, while the blue sequence that has been associated with debris of the satellite extends beyond that; (iv) there are density structures in the outer disc, both above and below the plane, most probably related to Monoceros, the Anticentre Stream, and TriAnd, for which the Gaia data allow an exhaustive selection of candidate member stars and dynamical study; and (v) the open clusters Berkeley 29 and Saurer 1, despite being located at large distances from the Galactic centre, are on nearly circular disc-like orbits., Conclusions. Even with our simple preliminary exploration of the Gaia EDR3, we demonstrate how, once again, these data from the European Space Agency are crucial for our understanding of the different pieces of our Galaxy and their connection to its global structure and history.
Published: 2021
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12. Cardiac surgery practice during the COVID-19 outbreak: a multicentre national survey

Author: G. Di Benedetto, Alessandro Parolari, G. Martinelli, P. Aniello, G. Gino, B. Valentino, M. Di Eusanio, C. Andrea, M. Massimo, L.S. De Santo, M. Francesco, D. F. Marisa, T. Michele, D. E. Marco, P. Alessandro, A. De Bellis, M. Gianluca, A. F. Pasquale, M. De Feo, Andrea Colli, S. Benussi, M. Lorenzo, T. Salvatore, P. Mastroroberto, G. Angelo Giuseppe, R. De Paulis, Carlo Pace Napoleone, D. B. Antonio, D. P. Ruggero, Luigi Chiariello, Massimo Massetti, C. Luigi, N. Carlo Pace, A. Pisano, G. Mattia, Alessandro Castiglioni, Giuseppe Faggian, Gino Gerosa, S. R. Antonino, N. Francesco, P. Francesco, Gabriele Iannelli, Mattia Glauber, Francesco Paolo Tritto, F. Giuseppe, M. Triggiani, T. Ragni, R. Temistocle, Michele Di Mauro, T. Francesco Paolo, D. M. Michele, P. Paolo, D. F. Carlo Maria, D. B. Giuseppe, P. Antonio, B. Stefano, S. Tribastone, Fabio Miraldi, L. Ugolino, B. Fiorani, Lorenzo Menicanti, Carlo Zebele, I. Severino, M. Gianfranco, P. A. Fratto, A. G. Giuffrida, F. Musumeci, Ugolino Livi, I. Gabriele, Valentino Borghetti, F. Patane, Severino Iesu, G. Montesi, M. Giuseppe, Z. Carlo, C. Alessandro, M. Fabio, Aniello Pappalardo, Antonino S. Rubino, R. Mauro, Francesco Nicolini, F. Brenno, D. S. Luca Salvatore, M. Pasquale, Mauro Rinaldi, G. Minniti, P. Panisi, C. M. De Filippo, Rubino, Antonino Salvatore, De Santo, Luca Salvatore, Pisano, Antonio, Mauro, Michele di, Benussi, Stefano, Borghetti, Valentino, Castiglioni, Alessandro, Chiariello, Luigi, Colli, Andrea, De Bellis, Antonio, De Filippo, Carlo Maria, De Paulis, Ruggero, Di Benedetto, Giuseppe, Di Eusanio, Marco, Faggian, Giuseppe, Fiorani, Brenno, Fratto, Pasquale Antonio, Giuffrida, Angelo Giuseppe, Glauber, Mattia, Iannelli, Gabriele, Iesu, Severino, Livi, Ugolino, Martinelli, Gianluca, Massetti, Massimo, Mastroroberto, Pasquale, Menicanti, Lorenzo, Minniti, Giuseppe, Miraldi, Fabio, Montesi, Gianfranco, Musumeci, Francesco, Nicolini, Francesco, Napoleone, Carlo Pace, Panisi, Paolo, Pappalardo, Aniello, Patanè, Francesco, Ragni, Temistocle, Rinaldi, Mauro, Tribastone, Salvatore, Triggiani, Michele, Tritto, Francesco Paolo, Zebele, Carlo, Parolari, Alessandro, Gerosa, Gino, and De Feo, Marisa
Subjects: Pulmonary and Respiratory Medicine, medicine.medical_specialty, Prioritization, Coronavirus disease 2019 (COVID-19), Waiting list, COVID-19 pandemic, 030204 cardiovascular system & hematology, Medical care, 03 medical and health sciences, 0302 clinical medicine, Healthcare resource, Health care, Pandemic, Medicine, Humans, 030212 general & internal medicine, Healthcare resources, Cardiac Surgical Procedures, Settore MED/23 - CHIRURGIA CARDIACA, Eacts/112, Pandemics, business.industry, AcademicSubjects/MED00920, SARS-CoV-2, Eacts/173, Outbreak, COVID-19, General Medicine, Cardiac surgery, Italy, Emergency medicine, Communicable Disease Control, Coronary care unit, Surgery, Original Article, Eacts/105, Cardiology and Cardiovascular Medicine, business, Healthcare system, Eacts/125
Abstract: OBJECTIVES Healthcare systems worldwide have been overburdened by the coronavirus disease 2019 (COVID-19) outbreak. Accordingly, hospitals had to implement strategies to profoundly reshape both non-COVID-19 medical care and surgical activities. Knowledge about the impact of the COVID-19 pandemic on cardiac surgery practice is pivotal. The goal of the present study was to describe the changes in cardiac surgery practices during the health emergency at the national level. METHODS A 26-question web-enabled survey including all adult cardiac surgery units in Italy was conducted to assess how their clinical practice changed during the national lockdown. Data were compared to data from the corresponding period in 2019. RESULTS All but 2 centres (94.9%) adopted specific protocols to screen patients and personnel. A significant reduction in the number of dedicated cardiac intensive care unit beds (−35.4%) and operating rooms (−29.2%), along with healthcare personnel reallocation to COVID departments (nurses −15.4%, anaesthesiologists −7.7%), was noted. Overall adult cardiac surgery volumes were dramatically reduced (1734 procedures vs 3447; P, The coronavirus disease 2019 (COVID-19) pandemic is the world’s largest infectious disease crisis in the last 100 years.
Published: 2021

13. Gaia early data release 3: summary of the contents and survey properties (Corrigendum)

Author: Mathias Schultheis, Marcella Marconi, N. Robichon, Luciana Bianchi, F. Crifo, J. Guiraud, D. Eappachen, R. Gutiérrez-Sánchez, Sanjeev Khanna, A. M. Piersimoni, Raphael Guerra, J. J. González-Vidal, J. J. Aguado, N. R. Millar, A. Baudesson-Stella, Tristan Cantat-Gaudin, Alejandra Recio-Blanco, Ummi Abbas, Francesca Figueras, R. Blomme, Elmé Breedt, G. Busso, A. Jean-Antoine Piccolo, Gerry Gilmore, A. Panahi, S. Messina, C. Babusiaux, Łukasz Wyrzykowski, Mark Taylor, Alex Bombrun, M. Barros, M. Riello, M. Ajaj, C. Ducourant, Tatiana Muraveva, Alberto Cellino, E. Poggio, Y. Le Fustec, C. P. Murphy, Maria-Rosa L. Cioni, Hector Canovas, D. L. Harrison, Y. Lasne, Elena Pancino, N. Bauchet, G. Orrù, Sergi Blanco-Cuaresma, Simon Hodgkin, Ennio Poretti, A. F. Lanza, Alberto Vecchiato, Thomas Wevers, Andrea Chiavassa, E. Szegedi-Elek, A. G. A. Brown, Laszlo Szabados, A. Masip, Laia Casamiquela, R. Messineo, C. Crowley, Alessandra Mastrobuono-Battisti, E. Poujoulet, Zoltan Balog, L. Eyer, A. Guerrier, H. E. P. Lindstrøm, Ilaria Musella, Laurent Galluccio, Martin A. Barstow, Aldo Dell'Oro, Mark Cropper, Z. Kostrzewa-Rutkowska, Angela Bragaglia, Arnaud Siebert, Damien Ségransan, A. Kochoska, J. L. Halbwachs, E. F. del Peloso, N. Hładczuk, F. Pailler, Stefan Jordan, Stefano Bertone, L. Pulone, Frédéric Arenou, Patrick Charlot, David Hobbs, P. Castro Sampol, Yves Fremat, Sofia Randich, Marc Audard, Despina Hatzidimitriou, A. Dapergolas, L. Palaversa, W. van Reeven, M. Hauser, E. Utrilla, Georges Kordopatis, Sergei A. Klioner, Alex Lobel, J.-L. Bassilana, G. Tauran, T. Prusti, H. Steidelmüller, Alberto Riva, Diego Bossini, Maria Süveges, Isabella Pagano, J. H. J. de Bruijne, Elisabetta Caffau, Federica Spoto, Felix Franke, T. Boch, M. I. Carnerero, T. Carlucci, Grigori Fedorets, J. Castañeda, W. Löffler, Enrique Solano, Paolo Montegriffo, A. Abreu Aramburu, T. Lebzelter, Nami Mowlavi, C. Barache, C. A. Stephenson, A. Lorca, L. Bramante, Amina Helmi, J.-B. Delisle, B. Holl, D. Molina, J. Fernández-Hernández, G. Jevardat de Fombelle, F. van Leeuwen, C. Robin, D. Katz, E. Gerlach, Elisa Distefano, Michele Bellazzini, P. de Laverny, G. Sadowski, Tomaz Zwitter, A. Burlacu, Teresa Antoja, Rossella Cancelliere, F. Torra, C. Pagani, Annie C. Robin, Johannes Sahlmann, Karri Muinonen, Eva Sciacca, D. Vicente, Krzysztof Nienartowicz, A. F. Mulone, Shay Zucker, Nicholas Rowell, H. E. Delgado, Dimitri Pourbaix, G. Giuffrida, H. E. Huckle, Federico Marocco, L. Noval, Daniel Michalik, P. J. Richards, Y. Viala, E. van Dillen, L. Karbevska, H. Zhao, L. Siltala, Nicoletta Sanna, K. Kruszyńska, E. Fraile, R. De March, Y. Lebreton, C. M. Raiteri, D. W. Evans, Ana Ulla, Francesca Fragkoudi, Jan Rybizki, E. Brugaletta, L. Rohrbasser, Andreas Korn, S. G. Baker, A. Garcia-Gutierrez, L. M. Sarro, R. Buzzi, T. Pauwels, Jérôme Berthier, L. Chaoul, W. J. Cooper, Eduard Masana, M. van Leeuwen, D. Garabato, P. Panuzzo, Maroussia Roelens, Benoit Carry, Deborah Busonero, Michael Davidson, J. González-Núñez, Thomas Hilger, E. Licata, M. Weiler, Mikael Granvik, Alessandro Bressan, Morgan Fouesneau, Miguel García-Torres, W. Roux, Pedro García-Lario, Iain A. Steele, P. Ramos, Alessandro Sozzetti, Roberto Molinaro, O. L. Creevey, D. Barbato, Lorenzo Rimoldini, Uwe Lammers, Alexey Mints, P. Sartoretti, E. Livanou, D. Souami, P. Madrero Pardo, David Teyssier, M. Bernet, Yassine Damerdji, X. Peñalosa Esteller, C. Fabre, F. Thévenin, Gérard Jasniewicz, Roberto Morbidelli, Jesus Salgado, Juan Zorec, Ángel Gómez, Douglas J. Marshall, A. G. Butkevich, M. Biermann, E. Racero, J. Torra, R. Gomel, O. Vanel, Daniel Hestroffer, Sebastian L. Hidalgo, P. A. Palicio, F. De Angeli, Richard L. Smart, J. M. Martín-Fleitas, Derek W. Morris, F. Royer, S. Diakite, S. Accart, C. Dolding, P. Burgess, Richard I. Anderson, A. Garofalo, I. Bellas-Velidis, George M. Seabroke, P. Osborne, Claus Fabricius, Jon Marchant, Ramachrisna Teixeira, João Alves, G. Gracia-Abril, R. Santoveña, R. Haigron, N. Unger, Lennart Lindegren, Isabelle Lecoeur-Taïbi, Paolo Giacobbe, Emese Plachy, M. Fabrizio, I. Gonzalez-Santamaria, F. Taris, Kevin Benson, Christos Siopis, M. M. S. Marcos Santos, S. Cowell, Jose M Hernandez, S. Ragaini, Jordi Portell, Linda K. Molnar, R. Drimmel, Pierre Kervella, C. Zurbach, S. Bartolomé, J. Álvarez Cid-Fuentes, E. Salguero, Ulrich Bastian, Robert G. Mann, Marco Castellani, J. Osinde, E. Balbinot, Caroline Soubiran, Rene Andrae, J. Souchay, M. G. Lattanzi, S. Voutsinas, Agnes Fienga, Giovanni Comoretto, P. Esquej, A. C. Lanzafame, Beatrice Bucciarelli, C. Panem, Carlos Dafonte, Alfred Castro-Ginard, J. C. Segovia, Monica Rainer, F. Julbe, A. Hutton, Peter G. Jonker, William Thuillot, A. de Torres, F. De Luise, Pierre Fernique, Céline Reylé, M. Kontizas, G. Plum, Martin Altmann, L. Martin Polo, M. Ramos-Lerate, P. de Teodoro, Sébastien Lambert, G. Altavilla, André Moitinho, D. Munoz, N. Brouillet, Alessandro Spagna, C. Ordénovic, Gisella Clementini, C. Nicolas, Michał Pawlak, Silvio Leccia, A. Delgado, M. Romero-Gómez, N. Cheek, A. Yoldas, Harry Enke, Rosanna Sordo, V. Sanchez Gimenez, Mike Smith, P. David, D. Baines, Paolo Tanga, Guy Rixon, Alberto Krone-Martins, S. Managau, N. A. Walton, S. Bouquillon, C. Fouron, Francois Mignard, Xavier Luri, J. Juaristi Campillo, S. Girona, Thierry Morel, T. Cornez, P. M. Marrese, M. A. Álvarez, S. Liao, Andrej Prsa, M. Sarasso, Nicolas Rambaux, Paul J. McMillan, Ludovic Delchambre, M. Garcia-Reinaldos, M. Haywood, E. Anglada Varela, Antonella Vallenari, S. Regibo, R. E. de Souza, Sahar Shahaf, J. De Ridder, M. Segol, Simchon Faigler, A. Mora, Ulrike Heiter, Carla Cacciari, Minia Manteiga, H. I. Siddiqui, Mario Gai, Leanne P. Guy, N. Leclerc, T. A. Lister, F. A. Jansen, Ruth Carballo, J. M. Carrasco, Bengt Edvardsson, P. Di Matteo, K. Janßen, F. Riclet, F. Solitro, O. Marchal, G. Holland, F. X. Pineau, C. Turon, P. Re Fiorentin, Tsevi Mazeh, Mariateresa Crosta, C. Diener, J. F. Le Campion, Vincenzo Ripepi, M. David, R. Mor, N. Tonello, E. del Pozo, J. Bakker, Davide Massari, A. Sagristà Sellés, Marco Delbo, Eric Slezak, P. Gavras, N. Samaras, S. Marinoni, M. Vaillant, J. M. Petit, P. Yvard, Carme Jordi, Ugo Becciani, Antti Penttilä, R. Geyer, Nigel Hambly, Krzysztof A. Rybicki, L. Balaguer-Núñez, C. A. L. Bailer-Jones, Conny Aerts, Eric Gosset, D. Semeux, T. Roegiers, and Laurent Chemin
Subjects: Physics, Addenda, 010504 meteorology & atmospheric sciences, Errata, Parallaxes, Astronomy, Astronomy and Astrophysics, Astrophysics, Astrometry, Photometric, 01 natural sciences, Techniques, catalogs, astrometry, parallaxes, proper motions, techniques: photometric, errata, addenda, Settore FIS/05 - Astronomia e Astrofisica, Space and Planetary Science, 0103 physical sciences, Proper motions, Catalogs, 010303 astronomy & astrophysics, Data release, 0105 earth and related environmental sciences
Abstract: We present the early installment of the third Gaia data release, Gaia EDR3, consisting of astrometry and photometry for 1.8 billion sources brighter than magnitude 21, complemented with the list of radial velocities from Gaia DR2. Gaia EDR3 contains celestial positions and the apparent brightness in G for approximately 1.8 billion sources. For 1.5 billion of those sources, parallaxes, proper motions, and the (G_BP-G_RP) colour are also available. The passbands for G, G_BP, and G_RP are provided as part of the release. For ease of use, the 7 million radial velocities from Gaia DR2 are included in this release, after the removal of a small number of spurious values. New radial velocities will appear as part of Gaia DR3. Finally, Gaia EDR3 represents an updated materialisation of the celestial reference frame (CRF) in the optical, the Gaia-CRF3, which is based solely on extragalactic sources. The creation of the source list for Gaia EDR3 includes enhancements that make it more robust with respect to high proper motion stars, and the disturbing effects of spurious and partially resolved sources. The source list is largely the same as that for Gaia DR2, but it does feature new sources and there are some notable changes. The source list will not change for Gaia DR3. Gaia EDR3 represents a significant advance over Gaia DR2, with parallax precisions increased by 30 percent, proper motion precisions increased by a factor of 2, and the systematic errors in the astrometry suppressed by 30--40 percent for the parallaxes and by a factor ~2.5 for the proper motions. The photometry also features increased precision, but above all much better homogeneity across colour, magnitude, and celestial position. A single passband for G, G_BP, and G_RP is valid over the entire magnitude and colour range, with no systematics above the 1 percent level.
Published: 2021

14. AB1411 JOINT RHEUMA-DERMA CLINIC: FOUR YEARS OF EXPERIENCE AT THE SAN MARCO HOSPITAL IN CATANIA

Author: R. Foti, G. Giuffrida, A. Ramondetta, E. Visalli, G. Amato, Y. Dal Bosco, F. De Lucia, and R. De Pasquale
Subjects: Rheumatology, Immunology, Immunology and Allergy, General Biochemistry, Genetics and Molecular Biology
Abstract: BackgroundPsoriatic arthritis (PsA) affects up to one-third of patients with psoriasis. Many recent works in literature have underline that the percentage of undiagnosed PsA is still high.A direct collaboration between dermatologists and rheumatologists appears fundamental for a better management of these patients, to reduce the risk of joint damage, disability, and comorbidities.ObjectivesThe aim of this study is to highlight the benefits of a Rheuma-Derma clinic and a shared approach, focused to an early diagnosis and prompt therapeutic strategy of PsA.MethodsPatients with psoriasis complaining joint symptoms or rheumatologic patients with cutaneous involvement, were simultaneously assessed by a dermatologist and a rheumatologist.The collected data included demographics, clinical characteristics as joint patterns (axial/peripheral), clinimetric index evaluated (DAS28, HAQ, BASDAI, DAPSA, PASI, PGA) family history of psoriasis or PsA, BMI (Mass Body Index), psoriasis, comorbidities and Charlson Index, gastrointestinal and ophthalmic involvement, and previous and current treatments with conventional (csDMARDS) and/or biological therapy (bDMARDs).ResultsDuring the period from 2012 to 2016 the Rheumatology Department registered 255 of patients under biological treatment, against 374 of patients during the Rheuma-Derma Clinic (2017-2021), with an increase of 47% in number. CsDMARDs therapy counted 367 patients before the Rheuma-Derma Clinic and 539 after the shared outpatient activity, with a raise of the 46%. Globally the number of patients with the diagnosis of PsA moved from 622 to 913, reaching an increase of 47% of patients.The joint pattern have shown a peripheral involvement in 69.3% of cases in comparison to 11% of cases with axial involvement and a mixed for the rest of population, 19.8%. In the group analyzed 539 patients were treated with csDMARDs, 76.5% methotrexate, 30.7% salazopyrine and only 6.7% with cyclosporine. 374 patients under treatment with bDMARD: the majority of patients (86.1%) were treated with TNFα inhibitors, 25.4% Secukinumab, 20.1% Ustekinumab, 16% Apremilast, 4.8% Ixekizumab, 1.1% Tofacitinib. The Charlson Comorbidity Index (CCI) assesses comorbidity level by taking into account the number, the severity of pre-defined comorbid conditions and the age of patients. It provides a weighted score in a range from 0 to 8, which can be used to predict short term and long-term outcomes such as function, hospital length of stay and mortality rates. In our study the majority of patients (27%) had a score of 2 while fortunately only 0.5% of population had a score of 8. The most frequent comorbidities registred in our cohort were hypertension (24.6%) and dyslipidemia (28.3%). Psoriasis was diagnosed in 41% of patients: in 80% of them the skin disease preceded the articular symptoms while 20% of patients developed psoriasis after the arthritis onset. History of family psoriasis was positive in 26% of patients. The nails involvement was observed only in 8% of patients, followed by gastrointestinal disorders (3%) and uveitis (7%). The value of BMI (Body Mass Index), the majority of patients (56%) have shown a normal weight, followed by over-weight patients (31.7%); only 10% of patients presented an obesity grade I and 1.1% an obesity grade II-III.For all the clinimetric index evaluated (DAS28, HAQ, BASDAI, DAPSA, PASI, PGA), there was an improvement over the twelve months under the Reuma-Derma clinicConclusionIn conclusion, the diagnosis of an Early PsA is essential, as an early treatment and management can alter the natural course of PsA and prevent irreversible joint damage. Our experience proved the increased number of patients since the Rheuma-Derma Clinic have started, such as an increased number of patients under treatment, leading to a significant improvement in the quality of life of PsA and Pso patients.References[1]Mease PJ J Am Acad Dermatol. 2013;69:729–735.[2]Scher JU Nat Rev Rheumatol. 2019 Mar;15(3):153-166.[3]Radtke MA J Eur Acad Dermatol Venereol. 2009 Jun;23(6):683-91. doi: 10.1111/j.1468-3083.2009.03159.xDisclosure of InterestsNone declared
Published: 2022

15. Gaia Early Data Release 3: Photometric content and validation

Author: G. Giuffrida, F. De Angeli, Carla Cacciari, G. Busso, Simon Hodgkin, S. Ragaini, L. Pulone, Anthony G. A. Brown, Nicholas A. Walton, D. W. Evans, D. L. Harrison, C. Diener, Marco Castellani, G. Holland, C. Fabricius, F. van Leeuwen, Paul W. Burgess, Nicoletta Sanna, M. Weiler, G. Altavilla, Nigel Hambly, S. Cowell, Gerard Gilmore, Michael Davidson, C. Pagani, F. De Luise, P. Osborne, S. Marinoni, A. M. Piersimoni, A. Yoldas, P. Montegriffo, L. Palaversa, Monica Rainer, Nicholas Rowell, Elena Pancino, P. J. Richards, Sebastian L. Hidalgo, Michele Bellazzini, Carme Jordi, J. M. Carrasco, M. Riello, Martin A. Barstow, Croatian Science Foundation, Agenzia Spaziale Italiana, Istituto Nazionale di Astrofisica, Ministerio de Ciencia, Innovación y Universidades (España), Particle Physics and Astronomy Research Council (UK), University of Bristol, UK Space Agency, University of Cambridge, University of Edinburgh, University of Leicester, University College London, Riello, Marco [0000-0002-3134-0935], Evans, Dafydd [0000-0002-6685-5998], Harrison, Diana [0000-0001-8687-6588], van Leeuwen, Floor [0000-0003-1781-4441], Gilmore, Gerard [0000-0003-4632-0213], Walton, Nicholas [0000-0003-3983-8778], and Apollo - University of Cambridge Repository
Subjects: FOS: Physical sciences, Context (language use), Astrophysics, Surveys, 7. Clean energy, 01 natural sciences, Instrumentation: photometers, Standard deviation, law.invention, Photometry (optics), law, 0103 physical sciences, Calibration, General, Galaxy: general, 010303 astronomy & astrophysics, Instrumentation, Instrumentation and Methods for Astrophysics (astro-ph.IM), general [Galaxy], Physics, Photometers, 010308 nuclear & particles physics, photometric [Techniques], Astronomy and Astrophysics, Astrometry, Photometer, Techniques, catalogs, surveys, instrumentation: photometers, techniques: photometric, Galaxy, photometers [Instrumentation], 13. Climate action, Space and Planetary Science, Magnitude (astronomy), Instrumentation and Methods for Astrophysics, Satellite, Catalogs, Astrophysics - Instrumentation and Methods for Astrophysics, Techniques: photometric, astro-ph.IM
Abstract: Riello, M., et al., [Context] Gaia Early Data Release 3 (Gaia EDR3) contains astrometry and photometry results for about 1.8 billion sources based on observations collected by the European Space Agency Gaia satellite during the first 34 months of its operational phase. [Aims] In this paper, we focus on the photometric content, describing the input data, the algorithms, the processing, and the validation of the results. Particular attention is given to the quality of the data and to a number of features that users may need to take into account to make the best use of the Gaia EDR3 catalogue. [Methods] The processing broadly followed the same procedure as for Gaia DR2, but with significant improvements in several aspects of the blue and red photometer (BP and RP) preprocessing and in the photometric calibration process. In particular, the treatment of the BP and RP background has been updated to include a better estimation of the local background, and the detection of crowding effects has been used to exclude affected data from the calibrations. The photometric calibration models have also been updated to account for flux loss over the whole magnitude range. Significant improvements in the modelling and calibration of the Gaia point and line spread functions have also helped to reduce a number of instrumental effects that were still present in DR2. Results. Gaia EDR3 contains 1.806 billion sources with G-band photometry and 1.540 billion sources with GBP and GRP photometry. The median uncertainty in the G-band photometry, as measured from the standard deviation of the internally calibrated mean photometry for a given source, is 0.2 mmag at magnitude G = 10-14, 0.8 mmag at G ≈ 17, and 2.6 mmag at G ≈ 19. The significant magnitude term found in the Gaia DR2 photometry is no longer visible, and overall there are no trends larger than 1 mmag mag-1. Using one passband over the whole colour and magnitude range leaves no systematics above the 1% level in magnitude in any of the bands, and a larger systematic is present for a very small sample of bright and blue sources. A detailed description of the residual systematic effects is provided. Overall the quality of the calibrated mean photometry in Gaia EDR3 is superior with respect to DR2 for all bands., The Gaia photometric data processing has been financially supported by (in alphabetical order by country): the Tenure Track Pilot Programme of the Croatian Science Foundation and the Ecole Polytechnique Fédérale de Lausanne and the Project TTP-2018-07-1171 Mining the Variable Sky, with funds of the Croatian-Swiss Research Programme; the Agenzia Spaziale Italiana (ASI) through contracts I/037/08/0, I/058/10/0, 2014-025-R.0, 2014-025-R.1.2015 and 2018-24-HH.0 to the Italian Istituto Nazionale di Astrofisica (INAF), and INAF; the Spanish Ministry of Science, Innovation and University (MICIU/FEDER, UE) through grants RTI2018-095076-B-C21, ESP2016-80079-C2-1-R, and the Institute of Cosmos Sciences University of Barcelona (ICCUB, Unidad de Excelencia “María de Maeztu”) through grants MDM-2014-0369 and CEX2019-000918-M; the United Kingdom Particle Physics and Astronomy Research Council (PPARC), the United Kingdom Science and Technology Facilities Council (STFC), and the United Kingdom Space Agency (UKSA) through the following grants to the University of Bristol, the University of Cambridge, the University of Edinburgh, the University of Leicester, the Mullard Space Sciences Laboratory of University College London, and the United Kingdom Rutherford Appleton Laboratory (RAL): PP/D006511/1, PP/D006546/1, PP/D006570/1, ST/I000852/1, ST/J005045/1, ST/K00056X/1, ST/K000209/1, ST/K000756/1, ST/L006561/1, ST/N000595/1, ST/N000641/1, ST/N000978/1, ST/N001117/1, ST/S000089/1, ST/S000976/1, ST/S001123/1, ST/S001948/1, ST/S002103/1, and ST/V000969/1.
Published: 2020
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16. Gaia Early Data Release 3: Acceleration of the solar system from Gaia astrometry

Author: Vincenzo Ripepi, P. Gavras, M. Vaillant, Mathias Schultheis, László Molnár, E. Poujoulet, Mark Cropper, C. Babusiaux, D. Molina, J. Fernández-Hernández, G. Jevardat de Fombelle, A. de Torres, Aldo Dell'Oro, J. Castañeda, Z. Kostrzewa-Rutkowska, A. Bombrun, André Moitinho, Marcella Marconi, Rossella Cancelliere, M. Hauser, M. Ajaj, C. M. Raiteri, L. Eyer, Michał Pawlak, H. I. Siddiqui, C. Ducourant, Tatiana Muraveva, Tsevi Mazeh, A. Panahi, Federico Marocco, Stefano Bertone, D. Vicente, Patrick Charlot, A. Guerrier, R. De March, Mario Gai, J. Souchay, H. E. P. Lindstrøm, Nicoletta Sanna, Agnes Fienga, Giovanni Comoretto, Jon Marchant, A. Lorca, E. Utrilla, A. Garcia-Gutierrez, Ilaria Musella, L. Balaguer-Núñez, Leanne P. Guy, N. Leclerc, E. Brugaletta, A. Yoldas, Harry Enke, Rosanna Sordo, Zoltan Balog, H. E. Huckle, L. Palaversa, Monica Rainer, T. A. Lister, F. A. Jansen, Ruth Carballo, Alessandro Spagna, J. M. Carrasco, Mikael Granvik, Derek W. Morris, F. Julbe, A. Hutton, J. Osinde, D. W. Evans, M. van Leeuwen, M. Weiler, F. Thévenin, F. Torra, Iain A. Steele, Lorenzo Rimoldini, Alessandro Sozzetti, Francesca Fragkoudi, K. Janßen, O. L. Creevey, J. González-Núñez, T. Pauwels, R. Buzzi, Miguel García-Torres, S. Liao, G. Tauran, Lennart Lindegren, C. Fouron, Pierre Fernique, Céline Reylé, P. Di Matteo, E. Szegedi-Elek, F. Pailler, Stefan Jordan, Roberto Molinaro, Elisabetta Caffau, Federica Spoto, Felix Franke, D. Barbato, Isabelle Lecoeur-Taïbi, Tristan Cantat-Gaudin, Alejandra Recio-Blanco, E. Livanou, W. Roux, X. Peñalosa Esteller, P. A. Palicio, J. H. J. de Bruijne, Sergi Blanco-Cuaresma, Deborah Busonero, F. Riclet, Conny Aerts, Georges Kordopatis, Guy Rixon, F. Solitro, Davide Massari, Mike Smith, D. Baines, Roberto Morbidelli, Gerry Gilmore, G. Plum, Alexey Mints, O. Marchal, Juan Zorec, Ángel Gómez, C. A. Stephenson, Michael Davidson, C. Fabricius, E. Licata, Sergio Messina, Laszlo Szabados, M. Biermann, A. Garofalo, G. Holland, F. De Angeli, Andreas Korn, E. Anglada Varela, Grigori Fedorets, S. Girona, E. Gerlach, Antonella Vallenari, M. Riello, Łukasz Wyrzykowski, Damien Ségransan, F. Taris, L. Bramante, Alberto Cellino, S. Regibo, Andrej Prsa, M. Sarasso, E. Poggio, W. Löffler, Paolo Giacobbe, Jordi Portell, Elisa Distefano, Eric Slezak, I. Bellas-Velidis, Nicolas Rambaux, E. Balbinot, J.-B. Delisle, Maroussia Roelens, E. Salguero, P. de Teodoro, E. van Dillen, Y. Lebreton, Francois Mignard, Sergei A. Klioner, Ulrich Bastian, N. Samaras, G. Orrù, R. E. de Souza, P. Esquej, Paul J. McMillan, A. C. Lanzafame, Sébastien Lambert, Beatrice Bucciarelli, Jose M Hernandez, M. Bernet, S. Ragaini, Gisella Clementini, A. F. Mulone, Ludovic Delchambre, C. Panem, Eric Gosset, P. David, M. Garcia-Reinaldos, Ana Ulla, F. Crifo, J. Guiraud, Mariateresa Crosta, L. Chaoul, C. Diener, Carlos Dafonte, Karri Muinonen, Alex Lobel, J.-L. Bassilana, Maria Süveges, Isabella Pagano, Dimitri Pourbaix, D. Eappachen, M. Haywood, R. Drimmel, Y. Viala, S. Voutsinas, D. Semeux, William Thuillot, N. A. Walton, Paolo Montegriffo, A. Abreu Aramburu, C. Fabre, H. Zhao, Alessandro Bressan, S. Bouquillon, Sanjeev Khanna, T. Lebzelter, N. Tonello, L. Siltala, M. G. Lattanzi, C. Crowley, P. Yvard, Carme Jordi, Elena Pancino, E. del Pozo, Jan Rybizki, Nami Mowlavi, C. Barache, Morgan Fouesneau, J. De Ridder, Ugo Becciani, Martin Altmann, F. van Leeuwen, P. M. Marrese, M. A. Álvarez, A. Jean-Antoine Piccolo, A. F. Lanza, Alberto Vecchiato, Thomas Wevers, Caroline Soubiran, C. P. Murphy, A. M. Piersimoni, Alessandra Mastrobuono-Battisti, Peter G. Jonker, A. Sagristà Sellés, T. Roegiers, S. Marinoni, Johannes Sahlmann, Rene Andrae, P. Sartoretti, G. Altavilla, Raphael Guerra, F. X. Pineau, M. Segol, T. Prusti, J. J. González-Vidal, J. J. Aguado, N. R. Millar, A. Baudesson-Stella, Andrea Chiavassa, Laurent Chemin, C. Turon, H. Steidelmüller, Douglas J. Marshall, A. G. Butkevich, Alberto Riva, P. de Laverny, Simchon Faigler, Laurent Galluccio, A. Mora, P. Re Fiorentin, C. Ordénovic, J. F. Le Campion, A. Delgado, V. Sanchez Gimenez, M. David, G. Sadowski, R. L. Smart, A. Masip, Laia Casamiquela, R. Messineo, R. Mor, J. Bakker, C. Dolding, J. M. Martín-Fleitas, S. Diakite, Coryn A. L. Bailer-Jones, D. Souami, P. Madrero Pardo, Martin A. Barstow, David Teyssier, Ummi Abbas, Jesus Salgado, Paolo Tanga, A. Burlacu, O. Vanel, Ulrike Heiter, Daniel Hestroffer, Sebastian L. Hidalgo, H. E. Delgado, Alberto Krone-Martins, C. Robin, Kevin Benson, Christos Siopis, S. Managau, P. Burgess, Tomaz Zwitter, M. M. S. Marcos Santos, S. Cowell, J. L. Halbwachs, Xavier Luri, Antti Penttilä, R. Geyer, Minia Manteiga, Yassine Damerdji, Nigel Hambly, S. Bartolomé, J. Álvarez Cid-Fuentes, P. Osborne, J. Juaristi Campillo, Mark Taylor, Richard I. Anderson, Y. Le Fustec, Thierry Morel, T. Cornez, Krzysztof A. Rybicki, L. Pulone, N. Bauchet, Pierre Kervella, C. Zurbach, Alfred Castro-Ginard, Frédéric Arenou, P. Ramos, Robert G. Mann, Annie C. Robin, J. C. Segovia, M. Barros, Hector Canovas, D. L. Harrison, Y. Lasne, L. Noval, David Hobbs, E. F. del Peloso, P. Castro Sampol, Yves Fremat, F. De Luise, Daniel Michalik, P. J. Richards, L. Karbevska, N. Hładczuk, K. Kruszyńska, T. Boch, Sofia Randich, A. G. A. Brown, C. Pagani, L. Martin Polo, M. Ramos-Lerate, Krzysztof Nienartowicz, Eduard Masana, E. Racero, E. Fraile, Marc Audard, N. Robichon, Luciana Bianchi, G. Gracia-Abril, R. Santoveña, R. Haigron, N. Unger, Jérôme Berthier, Despina Hatzidimitriou, R. Gutiérrez-Sánchez, M. Fabrizio, I. Gonzalez-Santamaria, A. Dapergolas, P. Panuzzo, Benoit Carry, Francesca Figueras, R. Blomme, Elmé Breedt, D. Munoz, Diego Bossini, G. Busso, D. Katz, Simon Hodgkin, Ennio Poretti, N. Brouillet, Marco Castellani, Nicholas Rowell, Arnaud Siebert, M. Romero-Gómez, Shay Zucker, W. van Reeven, A. Kochoska, G. Giuffrida, Eva Sciacca, T. Carlucci, L. M. Sarro, M. I. Carnerero, Amina Helmi, D. Garabato, B. Holl, Michele Bellazzini, L. Rohrbasser, Teresa Antoja, J. Torra, Thomas Hilger, Pedro García-Lario, Gérard Jasniewicz, Enrique Solano, S. G. Baker, W. J. Cooper, F. Royer, S. Accart, George M. Seabroke, João Alves, Emese Plachy, C. Nicolas, Silvio Leccia, N. Cheek, Uwe Lammers, Ramachrisna Teixeira, Techniche Universtât Desden, Joseph Louis LAGRANGE (LAGRANGE), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Lund Observatory, Lund University [Lund], Zentrum für astronomie, Universität Heidelberg [Heidelberg], Department of nuclear medicine, Haukeland University Hospital, University of Bergen (UiB)-University of Bergen (UiB), Merck Serono S.A [Geneva Research Center], Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut de Physique de Rennes (IPR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Universität Heidelberg [Heidelberg] = Heidelberg University, Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics (LESIA), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Planetary-system research, Department of Physics, Particle Physics and Astrophysics, Gaia Collaboration, Unidad de Excelencia Científica María de Maeztu Instituto de Ciencias del Cosmos Universidad de Barcelona, MDM-2014-0369, Centro de Excelencia Científica Severo Ochoa, Instituto de Ciencias del Cosmos de la Universidad de Barcelona, SEV2015-0493, Deliste, J. B. [0000-0001-5844-9888], Sozzeti, A. [0000-0002-7504-365X], Forderung der wissenschaftlichen Forschung (FWF), Belgian federal Science Policy Office (BELSPO), Hertha Firnberg Programme, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Comite Francais d'Evaluation de la Cooperation Universitaire et Scientifique avec le Bresil (COFECUB), National Natural Science Foundation of China (NSFC), China Scholarship Council (CSC), European Commission (EC), European Research Council (ERC), Hungarian National Research, Development, and Innovation Office (NKFIH), Science Foundation Ireland (SFI), Israel Science Foundation (ISF), Agenzia Spaziale Italiana (ASI), Istituto Nazionale di Astrofisica (INAF), Netherlands Research School for Astronomy (NOVA), Fundacao para a Ciencia e a Tecnologia (FCT), Agencia Estatal de Investigación (AEI), European Space Agency (ESA), Centre National D'Etudes Spatiales (CNES), Ministero dell'Istruzione, dell'Università e della Ricerca (MIUR), Narodowe Centrum Nauki (NCN), Slovenian Research Agency, Swedish National Space Agency (SNSA), United Kingdom Science and Technology Facilities Council (STFC), Universitat de Barcelona (UB), Generalitat de Catalunya, Xunta de Galicia, Universidad de Cantabria, ITA, European Commission, Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Economía y Competitividad (España), Astronomy, and Kapteyn Astronomical Institute
Subjects: Data Analysis, Solar System, Astronomy, kinematics and dynamics, virgo cluster, Astrophysics, 01 natural sciences, bar, Astronomi, astrofysik och kosmologi, large-magellanic-cloud, Methods, Astronomy, Astrophysics and Cosmology, 010303 astronomy & astrophysics, Physics, Astrophysics of Galaxies, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], Astrophysics::Instrumentation and Methods for Astrophysics, Astrometry, VIRGO CLUSTER, Kinematics and Dynamics, Amplitude, kinematics, Physical Sciences, MILKY-WAY, astrometry, Galaxy: kinematics and dynamics, PROPER MOTION, Proper motion, perturbation, proper motions, reference systems, methods: data analysis, Astrophysics - Astrophysics of Galaxies, FOS: Physical sciences, Context (language use), proper motion, Astronomy & Astrophysics, MASS, Computer Science::Digital Libraries, Gravitational potential, Acceleration, Settore FIS/05 - Astronomia e Astrofisica, 0103 physical sciences, data analysis [methods], Vector spherical harmonics, KINEMATICS, distance, milky-way, Science & Technology, PERTURBATION, 010308 nuclear & particles physics, Astronomy and Astrophysics, kinematics and dynamics [Galaxy], 115 Astronomy, Space science, Physics::History of Physics, BAR, Galaxy, Space and Planetary Science, [SDU]Sciences of the Universe [physics], Astrophysics of Galaxies (astro-ph.GA), DISTANCE, mass, LARGE-MAGELLANIC-CLOUD
Abstract: Context. Gaia Early Data Release 3 (Gaia EDR3) provides accurate astrometry for about 1.6 million compact (QSO-like) extragalactic sources, 1.2 million of which have the best-quality five-parameter astrometric solutions., Aims. The proper motions of QSO-like sources are used to reveal a systematic pattern due to the acceleration of the solar systembarycentre with respect to the rest frame of the Universe. Apart from being an important scientific result by itself, the acceleration measured in this way is a good quality indicator of the Gaia astrometric solution., Methods. Theeffect of the acceleration was obtained as a part of the general expansion of the vector field of proper motions in vector spherical harmonics (VSH). Various versions of the VSH fit and various subsets of the sources were tried and compared to get the most consistent result and a realistic estimate of its uncertainty. Additional tests with the Gaia astrometric solution were used to get a better idea of the possible systematic errors in the estimate., Results. Our best estimate of the acceleration based on Gaia EDR3 is (2.32 +/- 0.16) x 10(-10) m s(-2) (or 7.33 +/- 0.51 km s(-1) Myr-1) towards alpha = 269.1 degrees +/- 5.4 degrees, delta = -31.6 degrees +/- 4.1 degrees, corresponding to a proper motion amplitude of 5.05 +/- 0.35 mu as yr(-1). This is in good agreement with the acceleration expected from current models of the Galactic gravitational potential. We expect that future Gaia data releases will provide estimates of the acceleration with uncertainties substantially below 0.1 mu as yr(-1).
Published: 2020
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17. Doctor–couple communication during assisted reproductive technology visits

Author: Arne Luehwink, Daniela Leone, Lidia Borghi, C Filippini, Mauro Costa, L. De Lauretis, Alberto Revelli, F. Tomei, Elena Vegni, G. Tomasi, E. Chelo, S Del Negro, G. Giuffrida, R. Palermo, A. P. Ferraretti, C. Becattini, and Claudia Livi
Subjects: Adult, Male, medicine.medical_specialty, Reproductive Techniques, Assisted, communication content, medicine.medical_treatment, media_common.quotation_subject, MEDLINE, Context (language use), patient-centered score, doctor-patient communication, 03 medical and health sciences, Reproductive Techniques, 0302 clinical medicine, Pregnancy, medicine, Humans, Conversation, 030212 general & internal medicine, media_common, Physician-Patient Relations, 030219 obstetrics & reproductive medicine, Assisted reproductive technology, Socioemotional selectivity theory, Communication, Hawthorne effect, Rehabilitation, Obstetrics and Gynecology, ART, verbal dominance, Female, Italy, Treatment Outcome, Reproductive Medicine, Assisted, Family medicine, Models of communication, Observational study, Psychology
Abstract: Study question What are the characteristics of doctor-couple communication content during actual ART visits? Summary answer Physicians were mainly focused on providing biomedical information, while communication content from couples had a 2-fold focus on providing biomedical information and on positive talk. What is known already Communication aspects in ART seem crucial for clinical decision-making, retention in care and critical conversations with couples due to low treatment success rates. However, no studies have been carried out on the actual interaction between the doctor and the couple in this context. Study design, size, duration This observational study involved 28 clinicians and 160 patients referred to eight Italian ART clinics during a one-year recruitment period. Participants/materials, setting, methods ART visits at eight Italian clinics were videotaped. The visits were coded using the Roter Interaction Analysis System (RIAS), particularly focusing on RIAS composite categories, verbal dominance and patient-centeredness score. Main results and the role of chance A total of 85 visits were eligible for analysis (62% acceptance rate), involving 28 clinicians and 160 patients (including 75 couples). The average visit duration was 37 ± 17.7 min. The mean verbal dominance was 1.9 ± 0.86 (range: 0.72-5.74). Physicians mainly focused on providing biomedical information. Communication content from couples had a 2-fold focus on providing biomedical information and on positive talk. The mean of patient centeredness index (PCI) was 0.51 (SD = 0.28; range 0.08-1.77); visits in which the doctor was a woman or the treatment indication was for heterologous fertilization showed higher PCI scores. Overall, females accounted for 67% of all patient talk. Taking this imbalance into account as expected frequencies for each composite category, males reported significantly more utterances in almost all of the socioemotional categories. Limitations, reasons for caution These results are preliminary and observational and only regard Italy. Communication during visits may have been biased since the professionals who agreed to participate showed an interest in communication issues. Another limitation is a possible Hawthorne effect due to the fact that participants were aware of being videotaped. Wider implications of the findings Our study showed that ART physicians mainly adopted an informative model of communication and a more disease-oriented approach. Findings revealed the complexity of communication content during ART consultations, given its triadic characteristic in which the third party is also a patient; clinicians should be aware of this complex aspect and of the specific male and female perspectives to be taken into account. The results could be useful for training ART professionals. Study funding/competing interest(s) This study was possible thanks to an unconditional grant from Ferring Spa to the Department of Health Sciences, University of Milan. There are no competing interests to declare. Trial registration number N/A.
Published: 2018

18. Smoking is associated with a higher complication and failure rate in arteriovenous grafts for haemodialysis: A multi-centre experience

Author: Rosie Donne, Aaron Kler, Titus Augustine, Hussein Khambalia, Babatunde Campbell, David van Dellen, Zulfikar Pondor, and G. Giuffrida
Subjects: medicine.medical_specialty, Vascular disease, business.industry, medicine.medical_treatment, Mortality rate, Retrospective cohort study, medicine.disease, Thrombosis, Surgery, Nephrology, medicine, Smoking cessation, Medical history, Risk factor, business, Complication
Abstract: Introduction: Arteriovenous grafts (AVG) for haemodialysis (HD) access are recommended as a second line modality due to higher morbidity and mortality rates than arteriovenous fistulae (AVF). Smoking is already established as a risk factor in lower extremity bypass graft failure used for peripheral vascular disease, but its effect on AVGs remains unclear. We aimed to investigate the relationship of smoking on AVG outcomes. Methods: A 3 year (01/08/2015–01/08/2018) multi-centre retrospective study was carried out on patients receiving an AVG for HD. Data included patient demographics, medical history, operation, type of graft, postoperative course and primary and secondary patency rates. Statistical analyses performed were Kaplan-Meier curves and Cox’s proportional hazard regression. Results: Fifty-five AVGs were performed (1052 AVF performed) in this period. The most common complication was thrombosis (38.9%). Primary patency at 6, 12 and 24 months were 55%, 45% and 44% respectively. Secondary patency at 6, 12 and 24 months were 63%, 56% and 54% respectively. Smoking was found to be a poor prognostic factor for primary (HR 3.734 (1.818–7.668 95% CI) p Discussion: Primary patency rates are lower than previous reports whilst secondary patency is equivalent. Smoking results in a greater risk of thrombosis and poorer primary and secondary patency. This is recognised in vascular surgical grafts, but has not been previously described in AVGs for HD access. Smoking is a modifiable risk factor and as AVGs are typically used for end-stage vascular access patients. Pre-operative strategies to promote smoking cessation, including patient education and prehabilitation should be employed to improve outcomes.
Published: 2021

19. Thyroid disease and cancer in kidney transplantation: a single-center analysis

Author: Massimiliano Veroux, Anna Carbonaro, Daniela Corona, Salvatore Lo Bianco, Maria Teresa Cannizzaro, Rossella Gioco, Fausto Carbone, Alessia Giaquinta, G. Giuffrida, Matteo Angelo Cannizzaro, Pierfrancesco Veroux, and Chiara Palermo
Subjects: Male, Goiter, medicine.medical_treatment, Papillary, Gastroenterology, Fine needle aspiration citology, 0302 clinical medicine, Adenocarcinoma, Follicular, Thyroid Nodule, Thyroid cancer, Kidney transplantation, Cancer, Ultrasonography, Thyroid, Follicular, Thyroid nodule, Incidence, Thyroid disease, Immunosuppression, General Medicine, Middle Aged, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Thyroidectomy, Female, 030211 gastroenterology & hepatology, Research Article, Adult, medicine.medical_specialty, Biopsy, Fine-Needle, lcsh:Surgery, 03 medical and health sciences, Internal medicine, medicine, Humans, Thyroid Neoplasms, business.industry, lcsh:RD1-811, medicine.disease, Kidney Transplantation, Thyroid Diseases, Carcinoma, Papillary, Surgery, Transplantation, Kidney Failure, Chronic, business
Abstract: Background Thyroid diseases are frequent in patients with end-stage renal disease, but data on renal transplant recipients are conflicting. This study evaluated the incidence of thyroid disease and cancer in a population of kidney transplant recipients performed in a single center. Methods Seven hundred sixty patients receiving a kidney transplantation between January 2000 and October 2017 were followed with thyroid ultrasonography to determine nodules together with thyroid hormone levels. Ultrasound-guided fine-needle aspiration citology (FNAc) was performed to the nodules > 10 mm . Results Two hundred four patients (26.8%) patients demonstrated functional or morphologic changes in the thyroid gland compared with pre-transplant period. Among the 204 patients with newly diagnosed thyroid disease, 165 patients had single or multiple nodular lesions less than 1 cm in diameter, and were followed yearly. Nodule size progression was observed in 23 patients (13.9%), and they underwent a FNAc. A total of sixty-two patients (30.3%) underwent FNAc. The biopsy samples were cytologically interpreted as benign in 20 patients (32.2%), suspicious in 40 patients (64.5%), or at high risk of cancer in 2 patients (3.2%). Forty-two patients underwent total thyroidectomy. At histological examination, 18 patients had a thyroid cancer (papillary cancer in 17 patients, follicular cancer in one). Thyroid cancer was more frequent in male patients with a mean time from transplant to diagnosis of 5.6 years. At a mean follow-up was 8 ± 1.2 years, all patients are alive with a normal functioning graft. Conclusions Thyroid diseases are common in transplant recipients. Thyroid disease may evolve after transplantation, probably as a consequence of immunosuppression. A complete evaluation of thyroid disease is mandatory in kidney transplant recipients because early diagnosis and appropriate treatment of thyroid disease and cancer may significantly decrease the morbidity and mortality in these patients.
Published: 2019

20. Patient-centered communication, patient satisfaction, and retention in care in assisted reproductive technology visits

Author: G. Tomasi, A. P. Ferraretti, Alberto Revelli, G. Giuffrida, Daniela Leone, F. Tomei, E. Chelo, Elena Vegni, Claudia Filippini, Lidia Borghi, C. Becattini, R. Palermo, L. De Lauretis, S. Poli, Claudia Livi, Arne Luehwink, and Mauro Costa
Subjects: 0301 basic medicine, Adult, Male, medicine.medical_specialty, Adolescent, Reproductive Techniques, Assisted, medicine.medical_treatment, Retention in care, Reproductive medicine, Satisfaction, Context (language use), RIAS, 03 medical and health sciences, 0302 clinical medicine, Patient satisfaction, Patient-centered communication, Patient-Centered Care, Surveys and Questionnaires, Genetics, medicine, Humans, Assisted Reproduction Technologies, Genetics (clinical), Physician-Patient Relations, 030219 obstetrics & reproductive medicine, Assisted reproductive technology, Obstetrics and Gynecology, General Medicine, Middle Aged, Test (assessment), 030104 developmental biology, Reproductive Medicine, Italy, Content analysis, Patient Satisfaction, Family medicine, Conventional PCI, Female, Doctor-patient interaction, Psychology, Developmental Biology
Abstract: PURPOSE: To explore the association between patient-centered communication, patients’ satisfaction, and retention in care in assisted reproductive technology (ART) visits. METHODS: ART visits at eight Italian clinics were videotaped and coded using the Roter Interaction Analysis System, which includes a Patient-Centered Index (PCI), a summary “patient-centered communication” ratio. After the visit, patients completed a satisfaction questionnaire (SATQ). After 3 months, patients were asked about their retention in care. Spearman correlations and Mann-Whitney tests were used to test associations between the study variables; the open-ended item of SATQ was analyzed through content analysis. RESULTS: Eighty-five visits were videotaped (involving 28 gynecologists and 160 patients). PCI score (μ = 0.51 ± 0.28) revealed a more disease-oriented communication during the visit. Patients reported high levels of satisfaction with the visit and identified in the information provision or in the doctor’s humanity or kindness the main reasons of satisfaction. At the follow-up, the majority of the couples declared to have followed the clinicians’ recommendations and to have remained related to the ART center. No associations were found among the study variables, except for a lower male satisfaction among couples who declared to have changed ART clinic. CONCLUSIONS: Contrary to what was expected, the style of physician-patient communication was not found to be associated with patient satisfaction and retention in care. However, patients were highly satisfied and engaged. The actual meaning of a communication that is “patient-centered” in the ART context might be wider, including the couples’ need for information, as suggested by qualitative findings.
Published: 2019

21. On the use of field RR Lyrae as Galactic probes: I. The Oosterhoff dichotomy based on fundamental variables

Author: P. M. Marrese, S. Marinoni, G. Giuffrida, E. Valenti, Brian Chaboyer, E. Zoccali, Massimo Dall'Ora, I. Ferraro, Vittorio F. Braga, M. Fabrizio, Frédéric Thévenin, G. Iannicola, Branimir Sesar, G. Altavilla, Mario Nonino, Matteo Monelli, C. K. Gilligan, Christopher Sneden, George W. Preston, Giuliana Fiorentino, Andrew C. Layden, Massimo Marengo, D. Magurno, Giuseppe Bono, Fabrizio M., Bono G., Braga V.F., Magurno D., Marinoni S., Marrese P.M., Ferraro I., Fiorentino G., Giuffrida G., Iannicola G., Monelli M., Altavilla G., Chaboyer B., Dall'ora M., Gilligan C.K., Layden A., Marengo M., Nonino M., Preston G.W., Sesar B., Sneden C., Valenti E., Thevenin F., Zoccali E., Scuola Internazionale Superiore di Studi Avanzati / International School for Advanced Studies (SISSA / ISAS), INAF - Osservatorio Astronomico di Padova (OAPD), Istituto Nazionale di Astrofisica (INAF), Sciences pour l'environnement (SPE), Centre National de la Recherche Scientifique (CNRS)-Université Pascal Paoli (UPP), INAF - Osservatorio Astronomico di Trieste (OAT), Joseph Louis LAGRANGE (LAGRANGE), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 010504 meteorology & atmospheric sciences, Metallicity, FOS: Physical sciences, Scale (descriptive set theory), Astrophysics, RR Lyrae variable, 01 natural sciences, Standard deviation, Spectral line, Luminosity, Galactic halo, 0103 physical sciences, 010303 astronomy & astrophysics, ComputingMilieux_MISCELLANEOUS, Solar and Stellar Astrophysics (astro-ph.SR), 0105 earth and related environmental sciences, Physics, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], Settore FIS/05, Astronomy and Astrophysics, Astrophysics - Astrophysics of Galaxies, Galaxy: Halo-stars: Variables: Rr lyrae-techniques: Spectroscopic, Amplitude, Astrophysics - Solar and Stellar Astrophysics, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA)
Abstract: We collected a large data set of field RR Lyrae stars (RRLs) by using catalogues already available in the literature and Gaia DR2. We estimated the iron abundances for a sub-sample of 2,382 fundamental RRLs ($\Delta$S method: CaIIK, H$\beta$, H$\gamma$ and H$\delta$ lines) for which are publicly available medium-resolution SDSS-SEGUE spectra. We also included similar estimates available in the literature ending up with the largest and most homogeneous spectroscopic data set ever collected for RRLs (2,903). The metallicity scale was validated by using iron abundances based on high resolution spectra for a fundamental field RRL (V~Ind), for which we collected X-shooter spectra covering the entire pulsation cycle. The peak ([Fe/H]=-1.59$\pm$0.01) and the standard deviation ($\sigma$=0.43 dex) of the metallicity distribution agree quite well with similar estimates available in the literature. The current measurements disclose a well defined metal-rich tail approaching Solar iron abundance. The spectroscopic sample plotted in the Bailey diagram (period vs luminosity amplitude) shows a steady variation when moving from the metal-poor ([Fe/H]=-3.0/-2.5) to the metal-rich ([Fe/H]=-0.5/0.0) regime. The smooth transition in the peak of the period distribution as a function of the metallicity strongly indicates that the long-standing problem of the Oosterhoff dichotomy among Galactic globulars is the consequence of the lack of metal-intermediate clusters hosting RRLs. We also found that the luminosity amplitude, in contrast with period, does not show a solid correlation with metallicity. This suggests that period-amplitude-metallicity relations should be cautiously treated., Comment: 23 pages, 16 figures, 1 table. Accepted for publication in ApJ
Published: 2019
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22. Successful coronary artery bypass graft surgery in severe congenital factor VII deficiency: Perioperative treatment with pd‐factor VII concentrate

Author: G. Giuffrida, D. Nicolosi, A. Giuffrida, C. Rapisarda, V. Calafiore, and F. Di Raimondo
Subjects: Male, medicine.medical_specialty, Aged, Coronary Artery Bypass, Factor VII, Factor VII Deficiency, Hemorrhage, Humans, Treatment Outcome, Perioperative Care, Treatment outcome, MEDLINE, chemistry.chemical_compound, Medicine, Factor VII deficiency, Genetics (clinical), business.industry, Hematology, General Medicine, Perioperative, Surgery, medicine.anatomical_structure, chemistry, Perioperative care, business, Artery
Published: 2018

23. An all-sky catalogue of solar-type dwarfs for exoplanetary transit surveys

Author: G. Giuffrida, Juan Cabrera, V. Granata, Sergio Ortolani, Isabella Pagano, Ana M. Heras, P. M. Marrese, Roberto Ragazzoni, Demetrio Magrin, Heike Rauer, Laurent Gizon, Giampaolo Piotto, Don Pollacco, Valerio Nascimbeni, Magali Deleuil, Laboratoire d'Astrophysique de Marseille (LAM), and Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)
Subjects: media_common.quotation_subject, FOS: Physical sciences, Astrophysics, stars: statistics, 01 natural sciences, Methods statistical, 0103 physical sciences, Transit (astronomy), Instrumentation and Methods for Astrophysics (astro-ph.IM), planetary systems, 010303 astronomy & astrophysics, Solar and Stellar Astrophysics (astro-ph.SR), catalogues, media_common, Earth and Planetary Astrophysics (astro-ph.EP), Physics, methods: statistical, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], 010308 nuclear & particles physics, Astronomy, stars: solar-type, Astronomy and Astrophysics, Planetary system, Giant star, Exoplanet, Astrophysics - Solar and Stellar Astrophysics, [SDU]Sciences of the Universe [physics], Space and Planetary Science, Sky, Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Earth and Planetary Astrophysics
Abstract: Most future surveys designed to discover transiting exoplanets, including TESS and PLATO, will target bright (V3.0 subgiants. The relatively low amount of contamination (defined as the fraction of false positives, 14 page, 6 figures, 2 tables. Accepted in MNRAS
Published: 2016

24. Gaia Data Release 2

Author: H. E. Huckle, F. Riclet, R. Buzzi, D. J. Marshall, Deborah Busonero, Michael Davidson, C Boeche, Sergio Messina, F. X. Pineau, G. Jasniewicz, L. Balaguer-Núñez, C. A. L. Bailer-Jones, L. Chaoul, J. L. Halbwachs, D. Teyssier, A. F. Lanza, Alberto Vecchiato, Shay Zucker, Francois Taris, Conny Aerts, L. Pulone, Mario Gai, L. M. Sarro, Frédéric Arenou, Á. L. Juhász, Alessandro Bressan, Joao Alves, Morgan Fouesneau, David Hobbs, Yves Fremat, L. Ruiz-Dern, A. Hutton, Sofia Randich, Gerry Gilmore, D. Garabato, Leanne P. Guy, J. González-Núñez, M. Weiler, H. Steidelmüller, D. de Martino, M. A. Álvarez, Vincenzo Ripepi, G. Gracia-Abril, Uwe Lammers, P. de Laverny, G. Sadowski, Nicolas Mary, Bengt Edvardsson, Laszlo Szabados, Łukasz Wyrzykowski, David Barrado, Alberto Cellino, Damien Ségransan, T Roegiers, Olivier Wertz, A. Recio-Blanco, Sergei A. Klioner, J. Durán, A. Panahi, A. Karampelas, Alex Lobel, J.-L. Bassilana, H. Voss, Sven Zschocke, A. Bombrun, F. De Angeli, Toni Santana-Ros, J. C. Segovia, D. Vicente, S. Blanco-Cuaresma, A. G. Butkevich, M. Riello, Amina Helmi, J. Bakker, J. Souchay, A. Kewley, R Alvarez, Daniel Hestroffer, Sergey E. Koposov, Tsevi Mazeh, Maria Süveges, F. F. Suess, P. Drazinos, B. Holl, H. Ziaeepour, T. Wevems, Eva Sciacca, P. Esquej, A. Gueguen, J. Heu, R. Geyer, J. Fernández-Hernández, E. Licata, Laurent Galluccio, J. Cuypers, Peter G. Jonker, Ummi Abbas, Elena Pancino, Jean Surdej, E. Anglada Varela, Michele Bellazzini, Teresa Antoja, Martin A. Barstow, László Molnár, Isabella Pagano, E. Solano, E. Brugaletta, P. Koubsky, Paolo Tanga, Alberto Krone-Martins, M. Clotet, Nigel Hambly, R. L. Smart, Paolo Giacobbe, Simchon Faigler, G. Giuffrida, Aldo Dell'Oro, Yveline Lebreton, Stefano Bertone, Mario G. Lattanzi, Paul S. Barklem, D. Tapiador, Patrick Charlot, A. H. Andrei, Luciano Nicastro, S. Managau, Lorenzo Rimoldini, Mario Di Martino, Paolo Montegriffo, A. Abreu Aramburu, O. Marchal, Marcella Marconi, K. Janßen, K. Findeisen, Xavier Luri, A. Berihuete, M. Schultheis, P. Di Matteo, R. Mor, C. Barata, A. Mora, W. van Reeven, Mikael Granvik, M. Barros, Carine Babusiaux, A. G. A. Brown, Mark Taylor, Y. Le Fustec, T. Lebzelter, Nami Mowlavi, O. L. Creevey, F. Barblan, Thierry Morel, Timo Prusti, A. Riva, S. Girona, S. Liao, Viktor Votruba, Frédéric Royer, Laurent Chemin, G. Altavilla, A. M. Piersimoni, Davide Massari, Marco Delbo, S. Diakite, V. Valette, N. Bach, H. Lenhardt, André Moitinho, Christophe Barache, S. Galleti, Michał Pawlak, A. Yoldas, Harry Enke, Rosanna Sordo, A. Jean-Antoine-Piccolo, Patrice David, Giacomo Cannizzaro, W. Löffler, J. Torra, Tristan Cantat-Gaudin, Marc Audard, D. Katz, Jose M Hernandez, Gijs Nelemans, S. Ragaini, P. Osborne, D. Terrett, A. J. Falcão, D. L. Harrison, G. Plum, R. G. Mann, Ulrike Heiter, Carla Cacciari, Gal Matijevic, J. M. Petit, A. Titarenko, Despina Hatzidimitriou, Juan Zorec, Angela Bragaglia, Nicholas Rowell, Annie C. Robin, Mario David, Tri L. Astraatmadja, Giovanni Comoretto, F. Julbe, Derek W. Morris, R. Drimmel, F. García-Sedano, A. Dapergolas, L. Noval, Mike Smith, Grigori Fedorets, H. Palacin, L. Bramante, D. Molina, Jesus Salgado, C. Dolding, M. Vaillant, Daniel Michalik, H. I. Siddiqui, Minia Manteiga, P. J. Richards, D. Barbato, A. Fonti, Raphael Guerra, J. J. González-Vidal, E. del Pozo, Mariateresa Crosta, M. Žerjal, F. Torra Clotet, C. Diener, M. Hauser, G. Walmsley, Sonia Nieto, I. Bellas-Velidis, T. Boch, Antonella Vallenari, M. Segol, S. Voutsinas, F. Leroux, A. F. Mulone, Pierre Fernique, Céline Reylé, P. Panuzzo, W. Hofmann, S. Bouquillon, F. Crifo, S. Cowell, Ana Ulla, Benoit Carry, C. Ordenovic, F. Pailler, E. Utrilla, Dimitri Pourbaix, A. Hypki, Stefan Jordan, T. Carlucci, Gráinne Costigan, Alfred Castro-Ginard, C. Fabre, C. Crowley, R. Borrachero, Sébastien Lambert, J. H. J. de Bruijne, D. W. Evans, C. Turon, T. Brüsemeister, F. De Luise, R. Haigron, Carme Jordi, G. Marschalkó, C. von Essen, C. Pagani, Katrien Kolenberg, M. van Leeuwen, N. R. Millar, Gisella Clementini, A. de Torres, Ugo Becciani, S. Marinoni, Geraldine Bourda, A. F. Silva, L. Eyer, Misha Haywood, C. Fabricius, Krzysztof Nienartowicz, Miguel García-Torres, S. Regibo, P. Gavras, Gábor Marton, Elisa Distefano, A. Guerrier, H. E. P. Lindstrøm, N. A. Walton, N. Brouillet, G. Eynard Bontemps, T. A. Lister, F. A. Jansen, Ruth Carballo, Steve Vogt, J. M. Carrasco, G. Mantelet, M. Romero-Gómez, Ramachrisna Teixeira, Kjell Eriksson, A. Kochoska, Johannes Sahlmann, Joakim Klar, R. Gutiérrez-Sánchez, Ilaria Musella, L. Palaversa, Karri Muinonen, J. M. Martín-Fleitas, T. Sagristà Sellés, Marco Castellani, Y. Viala, Laia Casamiquela, R. Messineo, Eduard Masana, R. de Souza, H. Stoev, L. Siltala, B. Frezouls, E. Szegedi-Elek, Tomaz Zwitter, G. Kordopatis, C. Ducourant, Tatiana Muraveva, P. Burgess, J. De Ridder, E. Salguero, A. Burlacu, I-C. Shih, U. Stampa, V. Icardi, Iain A. Steele, Alessandro Sozzetti, M. Kontizas, Roberto Molinaro, F. Solitro, H. E. Delgado, G. Holland, J.-B. Lavigne, Andreas Korn, M. Biermann, E. Fraile, M. Fabrizio, Francesca Figueras, R. Blomme, P. Teyssandier, Elisabetta Caffau, G. Busso, Maroussia Roelens, Maarten A. Breddels, Simon Hodgkin, Luciana Bianchi, Olivier Bienaymé, Silvio Leccia, C. Le Poncin-Lafitte, Morgan Fraser, M. Ramos-Lerate, M. Gomes, N. Cheek, J. Osinde, Jérôme Berthier, Kevin Benson, Christos Siopis, P. Balm, E. Gosset, Yassine Damerdji, Richard I. Anderson, C. Zurbach, Jonas Debosscher, G. Cocozza, William O'Mullane, Andrea Chiavassa, F.E. van Leeuwen, Diego Bossini, Federica Spoto, G. Jevardat de Fombelle, Nicoletta Sanna, J. Guiraud, G. Tauran, K. W. Smith, E. Poujoulet, Mark Cropper, Z. Kostrzewa-Rutkowska, F. Glass, J. Gerssen, Thomas Hilger, C.A. Stephenson, D. Ordóñez-Blanco, Andrej Prsa, M. Sarasso, E. Kontizas, Luciana Federici, Paul J. McMillan, Nicolas Rambaux, Ludovic Delchambre, M. Garcia-Reinaldos, T. Pauwels, M. Farràs Casas, S. Bartholomé Muñoz, E. Livanou, E. Van Hemelryck, Roberto Morbidelli, R. Kohley, A. Garofalo, Jovan Veljanoski, Jon Marchant, Jordi Portell, Ulrich Bastian, M. Lopez, Bernardino Arcay, H. Savietto, Alessandro Spagna, A. C. Lanzafame, Beatrice Bucciarelli, C. Panem, Carlos Dafonte, Y. Lasne, P. Sartoretti, E. Racero, William Thuillot, A. Gavel, J. Castañeda, Gaetano Valentini, A. Rivard, E. Poggio, N. Garralda, R. De March, S. G. Baker, S. Accart, M. Altmann, F. Filippi, George M. Seabroke, F. Thévenin, A. van Elteren, Emese Plachy, Lennart Lindegren, Isabelle Lecoeur-Taïbi, Guy Rixon, S Uzzi, M Vaschetto, Francois Mignard, E. Antiche, P. M. Marrese, N. Leclerc, Caroline Soubiran, Rene Andrae, A. Delgado, and Rossella Cancelliere
Subjects: Physics, 010504 meteorology & atmospheric sciences, Astronomy, Astronomy and Astrophysics, galaxies: dwarf, Astrophysics, Astrometry, globular clusters: general, 01 natural sciences, Settore FIS/05 - Astronomia e Astrofisica, Space and Planetary Science, 0103 physical sciences, Local Group, astrometry, High Energy Physics, Galaxy: kinematics and dynamics, astrometry, globular clusters: general, galaxies: dwarf, Local Group, errata, addenda, Galaxy: kinematics and dynamics, addenda, 010303 astronomy & astrophysics, Data release, Astrophysique, errata, 0105 earth and related environmental sciences
Abstract: 0, info:eu-repo/semantics/published
Published: 2020

25. Evolution of a multi-stakeholder initiative of health promotion in 20 suburban Roman districts

Author: LG Sisti, A Corsaro, G Giuffrida, MC Galizi, Gianfranco Damiani, P Parente, and M.L. Di Pietro
Subjects: Health promotion, Public Health, Environmental and Occupational Health, Multi stakeholder, Business, Public administration, Settore MED/42 - IGIENE GENERALE E APPLICATA
Published: 2018

26. Gaia Data Release 2: Photometric content and validation

Author: P. M. Marrese, A. Delgado, C. Ducourant, P. J. Richards, G. Altavilla, Gerry Gilmore, G. Giuffrida, Łukasz Wyrzykowski, F. De Luise, A. M. Piersimoni, Michael Davidson, M. Riello, C. Diener, Anthony G. A. Brown, D. W. Evans, G. Cocozza, Jordi Portell, S. Marinoni, Marco Castellani, Nicoletta Sanna, A. Kewley, B. Holl, Martin A. Barstow, Michele Bellazzini, N. A. Walton, P. Burgess, P. Osborne, D. Terrett, C. Fabricius, S. Galleti, J. M. Carrasco, Carla Cacciari, Carme Jordi, L. Pulone, Thomas Wevers, D. L. Harrison, Sergey E. Koposov, F. De Angeli, S. Ragaini, G. Busso, Simon Hodgkin, L. Balaguer-Núñez, Paolo Montegriffo, F. van Leeuwen, L. Palaversa, Elena Pancino, CICEnergigune, Nelson Mandela Metropolitan University [Port Elizabeth, South Africa], Institute of Astronomy [Cambridge], University of Cambridge [UK] (CAM), Department of Biomedical, Metabolic and Neural Sciences [Modena], Centre d'études spatiales de la biosphère (CESBIO), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), INAF - Osservatorio Astronomico di Bologna (OABO), Istituto Nazionale di Astrofisica (INAF), Universitat de Barcelona (UB), Atotech Deutschland GmbH, Atotech, Hospital Israelita Albert Einstein, M2A 2018, Laboratoire d'Astrophysique de Bordeaux [Pessac] (LAB), Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Heckscher-Klinikum, Department of Astrophysics [Nijmegen], Institute for Mathematics, Astrophysics and Particle Physics (IMAPP), Radboud university [Nijmegen]-Radboud university [Nijmegen], Evans, Dafydd [0000-0002-6685-5998], Riello, Marco [0000-0002-3134-0935], Harrison, Diana [0000-0001-8687-6588], Hodgkin, Simon [0000-0002-5470-3962], Gilmore, Gerard [0000-0003-4632-0213], Walton, Nicholas [0000-0003-3983-8778], Apollo - University of Cambridge Repository, and Universitat de Barcelona
Subjects: Astrometria, Astronomy, FOS: Physical sciences, Astrophysics, Surveys, 01 natural sciences, Catàlegs d'estels, catalogs, surveys, instrumentation, photometers, techniques: photometric, galaxies: general, Star catalogs, Photometry (optics), 0103 physical sciences, Instruments astronòmics, 010303 astronomy & astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Remote sensing, Physics, 010308 nuclear & particles physics, Quality assessment, photometric [Techniques], Astronomical instruments, general [Galaxies], Astronomy and Astrophysics, Astrometry, Galaxies, Galàxies, [SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], instrumentation: photometers, photometers [Instrumentation], Space and Planetary Science, Content (measure theory), Catalogs, Astrophysics - Instrumentation and Methods for Astrophysics, Data release
Abstract: Aims. We describe the photometric content of the second data release of the Gaia project (Gaia DR2) and its validation along with the quality of the data. Methods. The validation was mainly carried out using an internal analysis of the photometry. External comparisons were also made, but were limited by the precision and systematics that may be present in the external catalogues used. Results. In addition to the photometric quality assessment, we present the best estimates of the three photometric passbands. Various colour-colour transformations are also derived to enable the users to convert between the Gaia and commonly used passbands. Conclusions. The internal analysis of the data shows that the photometric calibrations can reach a precision as low as 2 mmag on individual CCD measurements. Other tests show that systematic effects are present in the data at the 10 mmag level., Comment: This version has corrections to Appendix A. All the SDSS transformations have been corrected. Tables A.1 and A.2 have changed for the SDSS relationships. Three of the subfigures in Figure A.1 have changed. The author list has been expanded
Published: 2018
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27. Controlled, prospective, observational study on the efficiency and tolerability of a combination of potential Nrf2-inducing antioxidants and micronutrients as pre-treatment for ICSI in dyspermic patients with previous failure

Author: R, Rago, M, Gallo, A, Dal Lago, E, Licata, G, Paciotti, M, Amodei, C, Meneghini, C, Fabiani, G, Dani, C, Liberanome, D, Antonaci, R, Corno, D, Miriello, G, Giuffrida, and B, Giammusso
Subjects: Male, Pregnancy Rate, Fertilization in Vitro, Embryo Transfer, Spermatozoa, Antioxidants, Italy, Pregnancy, Humans, Female, Micronutrients, Prospective Studies, Sperm Injections, Intracytoplasmic, Infertility, Male
Abstract: To evaluate the efficiency of pre-treatment in dyspermic males in IVF couples with a combination of micronutrients, for the purpose of improving the fertilization rate, the implantation rate and the outcome of the pregnancy.This controlled prospective clinical study was performed in two medically assisted reproduction centers. 59 males with mild oligo-astheno-teratospermia (OAT) were admitted to the study. All of them had a history of previous in vitro fertilization (IVF) attempts with female partners aged40 diagnosed having tubal or idiopathic infertility. The subjects upon enrolment underwent a semen test and afterward were treated with alpha lipoic acid and glutathione (Fertiplus SOD®, Idi-Pharma, Catania, Italy) for 4 weeks (short-term). The primary endpoints that were evaluated are the following: fertilization rate (mean fertilization), implantation rate and pregnancy rate.At the end of this study all the males (mean age 39.5 ± 5.1) reported in not having any side effects during the administration of Fertiplus. Their female partners (mean age 34.9 ± 4.5) underwent IVF using the ICSI technique. The number of oocytes retrieved and inseminated was not statistically different in comparison to previous attempts, but with the same number of oocytes treated, the fertilization rate per couple demonstrated statistically significant increase (p0.001). We did not observe a percentage increase in evolutionary embryos, but we noticed an improvement in embryo quality per individual couple (p0.001), associated with a net increase in the implantation rate per couple (p0.001) in terms of clinical pregnancy. The estimated miscarriage risk after treatment was five times lower (p0.001).Short-term treatment with micronutrients in dyspermic subjects can improve the reproductive outcome of the IVF procedure.
Published: 2017

28. Gaia Data Release 1: catalogue validation

Author: G. Giuffrida, I.-C. Shih, Amina Helmi, Angela Bragaglia, André Moitinho, Nicholas A. Walton, C. Babusiaux, H. Ziaeepour, Alberto Krone-Martins, E. Antiche, Frédéric Arenou, Céline Reylé, F. Figueras, P. M. Marrese, N. Leclerc, Xavier Luri, Caroline Soubiran, Sergi Blanco-Cuaresma, L. Ruiz-Dern, J. Souchay, M. Barros, C. Fabricius, Carme Jordi, Elena Pancino, Antonella Vallenari, Annie C. Robin, Rosine Lallement, Sébastien Lambert, Maarten A. Breddels, S. Soria, M. Romero-Gómez, K. Findeisen, G. Costigan, R. Sordo, J. Heu, Laurent Galluccio, R. Mor, C. Turon, J. M. Carrasco, S. Diakite, Tristan Cantat-Gaudin, Laurent Eyer, C. Barache, P. Sartoretti, Jovan Veljanoski, Galaxies, Etoiles, Physique, Instrumentation (GEPI), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut de Ciènces del Cosmos (ICC), Universitat de Barcelona (UB), Kapteyn Astronomical Institute [Groningen], University of Groningen [Groningen], Univers, Transport, Interfaces, Nanostructures, Atmosphère et environnement, Molécules (UMR 6213) (UTINAM), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), INAF - Osservatorio Astronomico di Padova (OAPD), Istituto Nazionale di Astrofisica (INAF), Observatoire Astronomique de l'Université de Genève (ObsGE), Université de Genève (UNIGE), Institute of Astronomy [Cambridge], University of Cambridge [UK] (CAM), Systèmes de Référence Temps Espace (SYRTE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Universidade de Lisboa (ULISBOA), Leiden Observatory [Leiden], Universiteit Leiden [Leiden], Joseph Louis LAGRANGE (LAGRANGE), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), INAF - Osservatorio Astronomico di Roma (OAR), M2A 2017, Laboratoire d'Astrophysique de Bordeaux [Pessac] (LAB), Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), INAF - Osservatorio Astrofisico di Arcetri (OAA), INAF - Osservatorio Astronomico di Bologna (OABO), Université de Genève = University of Geneva (UNIGE), Universidade de Lisboa = University of Lisbon (ULISBOA), Universiteit Leiden, Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), and Astronomy
Subjects: Cúmuls de galàxies, 010504 meteorology & atmospheric sciences, Astrometria, Computer science, FOS: Physical sciences, Paral·laxi, computer.software_genre, 01 natural sciences, astrometry, parallaxes, proper motions, methods: data analysis, surveys, catalogs, Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Astrophysics of Galaxies, Astrophysics - Solar and Stellar Astrophysics, proper motions, surveys, 0103 physical sciences, 010303 astronomy & astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Parallax, Solar and Stellar Astrophysics (astro-ph.SR), 0105 earth and related environmental sciences, Clusters of galaxies, Astronomy and Astrophysics, Astrometry, Galaxies, methods: data analysis, Astrophysics - Astrophysics of Galaxies, [SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Galàxies, Astrophysics - Solar and Stellar Astrophysics, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), parallaxes, astrometry, [SDU.ASTR.GA]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Galactic Astrophysics [astro-ph.GA], Data mining, Astrophysics - Instrumentation and Methods for Astrophysics, Data release, computer, catalogs
Abstract: Before the publication of the Gaia Catalogue, the contents of the first data release have undergone multiple dedicated validation tests. These tests aim at analysing in-depth the Catalogue content to detect anomalies, individual problems in specific objects or in overall statistical properties, either to filter them before the public release, or to describe the different caveats of the release for an optimal exploitation of the data. Dedicated methods using either Gaia internal data, external catalogues or models have been developed for the validation processes. They are testing normal stars as well as various populations like open or globular clusters, double stars, variable stars, quasars. Properties of coverage, accuracy and precision of the data are provided by the numerous tests presented here and jointly analysed to assess the data release content. This independent validation confirms the quality of the published data, Gaia DR1 being the most precise all-sky astrometric and photometric catalogue to-date. However, several limitations in terms of completeness, astrometric and photometric quality are identified and described. Figures describing the relevant properties of the release are shown and the testing activities carried out validating the user interfaces are also described. A particular emphasis is made on the statistical use of the data in scientific exploitation., Comment: 34 pages, 52 figures, 3 tables. Submitted to A&A on Oct. 14 as part of the Gaia DR1 special issue, accepted with minor revisions on Dec. 19
Published: 2017

29. Spectroscopic identification of r-process nucleosynthesis in a double neutron-star merger

Author: Massimo Capaccioli, Elena Pian, Luciano Nicastro, Enrico Cappellaro, M. Boer, Luca Limatola, Antonio Giunta, Gianpiero Tagliaferri, G. Greco, Chryssa Kouveliotou, Chris M. Copperwheat, M. Razzano, S. Klose, Stefano Benetti, Eleonora Troja, A. Grado, Andrew J. Levan, A. Pescalli, L. Pulone, Tsvi Piran, Masaomi Tanaka, S. D. Vergani, Zhi-Ping Jin, G. Ghirlanda, Jens Hjorth, M. Branchesi, Stefano Covino, F. Bufano, P. D'Avanzo, Gabriele Ghisellini, Piergiorgio Casella, E. Chassande-Mottin, Mario Spera, Antonio Stamerra, Riccardo Ciolfi, Sergio Campana, Yi-Zhong Fan, G. De Cesare, Lorenzo Amati, S. Piranomonte, Pietro Schipani, A. Di Paola, Jonatan Selsing, B. Patricelli, M. G. Bernardini, Fedor Getman, Eliana Palazzi, N. Masetti, L. Nava, G. Stratta, Om Sharan Salafia, Darach Watson, Sheng Yang, G. Giuffrida, A. Possenti, Bruce Gendre, M. Dadina, Luigi Stella, Per Møller, D. Malesani, Enzo Brocato, G. L. Israel, Andrea Rossi, A. Melandri, Massimo Turatto, Francesco Longo, L. Tomasella, Ruben Salvaterra, Daniel A. Perley, Nial R. Tanvir, Elisabetta Maiorano, Paolo A. Mazzali, Michela Mapelli, L. K. Hunt, A. J. Castro-Tirado, D. Vergani, Louis Antonelli, Vincenzo Testa, S. Ascenzi, Johan P. U. Fynbo, M. Lisi, Andrea Bulgarelli, Valerio D'Elia, Mansi M. Kasliwal, Laboratoire Univers et Particules de Montpellier (LUPM), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Astrophysique Relativiste Théories Expériences Métrologie Instrumentation Signaux (ARTEMIS), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Galaxies, Etoiles, Physique, Instrumentation (GEPI), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Pian, E., D'Avanzo, P., Benetti, S., Branchesi, M., Brocato, E., Campana, S., Cappellaro, E., Covino, S., D'Elia, V., Fynbo, J. P. U., Getman, F., Ghirlanda, G., Ghisellini, G., Grado, A., Greco, G., Hjorth, J., Kouveliotou, C., Levan, A., Limatola, L., Malesani, D., Mazzali, P. A., Melandri, A., Møller, P., Nicastro, L., Palazzi, E., Piranomonte, S., Rossi, A., Salafia, O. S., Selsing, J., Stratta, G., Tanaka, M., Tanvir, N. R., Tomasella, L., Watson, D., Yang, S., Amati, L., Antonelli, L. A., Ascenzi, S., Bernardini, M. G., Boër, M., Bufano, F., Bulgarelli, A., Capaccioli, M., Casella, P., Castro-Tirado, A. J., Chassande-Mottin, E., Ciolfi, R., Copperwheat, C. M., Dadina, M., De Cesare, G., Di Paola, A., Fan, Y. Z., Gendre, B., Giuffrida, G., Giunta, A., Hunt, L. K., Israel, G. L., Jin, Z. -P., Kasliwal, M. M., Klose, S., Lisi, M., Longo, F., Maiorano, E., Mapelli, M., Masetti, N., Nava, L., Patricelli, B., Perley, D., Pescalli, A., Piran, T., Possenti, A., Pulone, L., Razzano, M., Salvaterra, R., Schipani, P., Spera, M., Stamerra, A., Stella, L., Tagliaferri, G., Testa, V., Troja, E., Turatto, M., Vergani, S. D., Vergani, D., Laboratoire Univers et Particules de Montpellier ( LUPM ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Montpellier 2 - Sciences et Techniques ( UM2 ) -Université de Montpellier ( UM ), Astrophysique Relativiste Théories Expériences Métrologie Instrumentation Signaux ( ARTEMIS ), Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire de la Côte d'Azur, Université Côte d'Azur ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ), AstroParticule et Cosmologie ( APC - UMR 7164 ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Galaxies, Etoiles, Physique, Instrumentation ( GEPI ), Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), PSL Research University (PSL)-PSL Research University (PSL)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Observatoire de Paris, and PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)
Subjects: velocity, [ PHYS.ASTR ] Physics [physics]/Astrophysics [astro-ph], Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Gravitational Wave, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Kilonova, gamma ray: burst, 01 natural sciences, Spectral line, Multidisciplinary, Gamma Ray Burst, Chemical Evolution, Settore FIS/05 - Astronomia e Astrofisica, Nucleosynthesis, 0103 physical sciences, ultraviolet, optical, Astrophysics::Solar and Stellar Astrophysics, platinum, n: capture, 10. No inequality, Ejecta, neutron star, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, QB, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, mass: solar, 010308 nuclear & particles physics, gravitational radiation, Astronomy, nucleosynthesis, opacity, gold, Galaxy, observatory, Neutron star, 13. Climate action, r-process, spectral, galaxy, Gamma-ray burst, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], absorption
Abstract: The merger of two neutron stars is predicted to give rise to three major detectable phenomena: a short burst of gamma-rays, a gravitational wave signal, and a transient optical/near-infrared source powered by the synthesis of large amounts of very heavy elements via rapid neutron capture (the r-process). Such transients, named "macronovae" or "kilonovae", are believed to be centres of production of rare elements such as gold and platinum. The most compelling evidence so far for a kilonova was a very faint near-infrared rebrightening in the afterglow of a short gamma-ray burst at z = 0.356, although findings indicating bluer events have been reported. Here we report the spectral identification and describe the physical properties of a bright kilonova associated with the gravitational wave source GW 170817 and gamma-ray burst GRB 170817A associated with a galaxy at a distance of 40 Mpc from Earth. Using a series of spectra from ground-based observatories covering the wavelength range from the ultraviolet to the near-infrared, we find that the kilonova is characterized by rapidly expanding ejecta with spectral features similar to those predicted by current models. The ejecta is optically thick early on, with a velocity of about 0.2 times light speed, and reaches a radius of about 50 astronomical units in only 1.5 days. As the ejecta expands, broad absorption-like lines appear on the spectral continuum indicating atomic species produced by nucleosynthesis that occurs in the post-merger fast-moving dynamical ejecta and in two slower (0.05 times light speed) wind regions. Comparison with spectral models suggests that the merger ejected 0.03-0.05 solar masses of material, including high-opacity lanthanides., version accepted for publication in Nature. Some minor changes are expected with respect to the journal version
Published: 2017

30. GRAWITA: VLT Survey Telescope observations of the gravitational wave sources GW150914 and GW151226

Author: Enrico Cappellaro, Andrea Rossi, G. L. Israel, Mauro Dadina, V. D'Elia, L. A. Antonelli, Luca Limatola, Aniello Grado, S. Benetti, G. Greco, N. Masetti, Giancarlo Ghirlanda, Stefano Covino, Ruben Salvaterra, P. M. Marrese, Vincenzo Testa, Mario Radovich, Massimo Capaccioli, Luigi Stella, A. Stamerra, S. Ascenzi, A. Possenti, L. Pulone, G. Tagliaferri, G. Iannicola, M. Lisi, Pietro Schipani, Andrea Bulgarelli, Enzo Brocato, B. Patricelli, P. D'Avanzo, Lorenzo Amati, Michela Mapelli, Sergio Campana, M. Branchesi, A. Melandri, Fedor Getman, Eliana Palazzi, S. Piranomonte, G. Cella, S. Marinoni, G. Stratta, M. Razzano, Francesco Longo, L. Tomasella, Gabriele Ghisellini, G. Giuffrida, Luciano Nicastro, G. De Cesare, Sheng Yang, Mario Spera, Grawita-Gravitational Wave Inaf Team, Elena Pian, ITA, Brocato, E., Branchesi, M., Cappellaro, E., Covino, S., Grado, A., Greco, G., Limatola, L., Stratta, G., Yang, S., Campana, S., D'Avanzo, P., Getman, F., Melandri, A., Nicastro, L., Palazzi, E., Pian, E., Piranomonte, S., Pulone, L., Rossi, A., Tomasella, L., Amati, L., Antonelli, L. A., Ascenzi, S., Benetti, S., Bulgarelli, A., Capaccioli, M., Cella, G., Dadina, M., De Cesare, G., D'Elia, V., Ghirlanda, G., Ghisellini, G., Giuffrida, G., Iannicola, G., Israel, G., Lisi, M., Longo, F., Mapelli, M., Marinoni, S., Marrese, P., Masetti, N., Patricelli, B., Possenti, A., Radovich, M., Razzano, M., Salvaterra, R., Schipani, P., Spera, M., Stamerra, A., Stella, L., Tagliaferri, G., and Testa, V.
Subjects: Image processing - gammaray burst, Black holes - techniques, Gravitational wave - stars, GRB150827A, Individual, Astronomy and Astrophysics, Space and Planetary Science, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, Settore FIS/05 - Astronomia e Astrofisica, 0103 physical sciences, GW151226, 010306 general physics, 010303 astronomy & astrophysics, VLT Survey Telescope, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Gravitational wave, Astronomy, Astronomy and Astrophysic, LIGO, Supernova, Gravitational wave - star, Black holes - technique, Limiting magnitude, Astrophysics - High Energy Astrophysical Phenomena, Fermi Gamma-ray Space Telescope
Abstract: We report the results of deep optical follow-up surveys of the first two gravitational-wave sources, GW150914 and GW151226, done by the GRAvitational Wave Inaf TeAm Collaboration (GRAWITA). The VLT Survey Telescope (VST) responded promptly to the gravitational-wave alerts sent by the LIGO and Virgo Collaborations, monitoring a region of $90$ deg$^2$ and $72$ deg$^2$ for GW150914 and GW151226, respectively, and repeated the observations over nearly two months. Both surveys reached an average limiting magnitude of about 21 in the $r-$band. The paper describes the VST observational strategy and two independent procedures developed to search for transient counterpart candidates in multi-epoch VST images. Several transients have been discovered but no candidates are recognized to be related to the gravitational-wave events. Interestingly, among many contaminant supernovae, we find a possible correlation between the supernova VSTJ57.77559-59.13990 and GRB150827A detected by {\it Fermi}-GBM. The detection efficiency of VST observations for different types of electromagnetic counterparts of gravitational-wave events are evaluated for the present and future follow-up surveys., Comment: 26 pages, 11 figures- Submitted to MNRAS
Published: 2017
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31. Globular clusters with Gaia

Author: Elena Pancino, Michele Bellazzini, G. Giuffrida, S. Marinoni, and ITA
Subjects: Physics, 010308 nuclear & particles physics, FOS: Physical sciences, Astronomy, Astronomy and Astrophysics, Astrometry, Astrophysics, 01 natural sciences, Crowding, Astrophysics - Astrophysics of Galaxies, Photometry (optics), Stars, Photometric calibration, Astrophysics - Solar and Stellar Astrophysics, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), Globular cluster, 0103 physical sciences, Cluster (physics), 010303 astronomy & astrophysics, Solar and Stellar Astrophysics (astro-ph.SR)
Abstract: The treatment of crowded fields in Gaia data will only be a reality in a few years from now. In particular, for globular clusters, only the end-of-mission data (public in 2022-2023) will have the necessary full crowding treatment and will reach sufficient quality for the faintest stars. As a consequence, the work on the deblending and decontamination pipelines is still ongoing. We describe the present status of the pipelines for different Gaia instruments, and we model the end-of-mission crowding errors on the basis of available information. We then apply the nominal post-launch Gaia performances, appropriately worsened by the estimated crowding errors, to a set of 18 simulated globular clusters with different concentration, distance, and field contamination. We conclude that there will be 103-104 stars with astrometric performances virtually untouched by crowding (contaminated by, 16 pages, 16 figures, 5 tables (of which 1 online), accepted for publication by MNRAS
Published: 2017

32. An overview on contemporary rammed earth buildings: technological advances in production, construction and material characterization

Author: Rosa Caponetto, G Giuffrida, and Massimo Cuomo
Subjects: Rammed earth, Engineering, business.industry, Production (economics), business, Construction engineering, Characterization (materials science)
Abstract: Raw earth is a traditional material used worldwide in vernacular architectures. For its wide availability, recyclability and low embodied energy in its life cycle, earth is acknowledged as one of the most environmentally sustainable material. Earth construction diffusion has been slowed by the lack of broadly accepted standards. Due to it, earth has been used as an artisanal material or adapted to existing technologies in combination with high embodied energy materials as steel, concrete and EPS or PU insulations (as in rammed earth technique, from now on RE). Aim of the research is to propose an innovative RE constructive technology, more coherent with the sustainable features of the base material, which can reach the high performances and the quality target required by the constructions sector using a low-tech prefabrication process. Prefabrication of RE elements can also reduce the construction times and the risks of technological faults, enhancing the quality of the entire building. The basic idea is to create manageable and transportable rammed earth panels with superior mechanical and thermal performances. The prefabrication under controlled conditions ensures a high-quality product which can be combined, on site, with a reinforcing timber structure with anti-seismic function. A characterization campaign on different local soils has been performed in order to implement the desired RE elements. The soils have been analysed with a set of geotechnical tests and qualitative assessments in order to detect their suitability for constructions. Once a suitable soil has been identified, a physical and / or chemical stabilization is needed to improve the physical features, mechanical characteristics and thermal properties of the natural soil. In the last section of the paper, the first results on natural local soil and engineered soil (an optimized mix of soil, sand and gravel) are presented and compared to identify a suitable material for the RE panel.
Published: 2019

33. Immunochip analysis identifies novel susceptibility loci in the human leukocyte antigen region for acquired thrombotic thrombocytopenic purpura

Author: I. Mancini, I. Ricaño‐Ponce, E. Pappalardo, A. Cairo, M.M. Gorski, G. Casoli, B. Ferrari, M. Alberti, D. Mikovic, M. Noris, C. Wijmenga, F. Peyvandi, E. Rinaldi, A. Melpignano, S. Campus, R.A. Podda, C. Caria, A. Caddori, E. Di Francesco, G. Giuffrida, V. Agostini, U. Roncarati, C. Mannarella, A. Fragasso, G.M. Podda, E. Bertinato, A.M. Cerbone, A. Tufano, G. Loffredo, V. Poggi, M. Pizzuti, G. Re, M. Ronchi, K. Codeluppi, L. Facchini, A. De Fanti, S. Amarri, S.M. Trisolini, S. Capria, L. Aprile, M. Defina, S. Cerù, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Mancini, I., Ricano-Ponce, I., Pappalardo, E., Cairo, A., Gorski, M. M., Casoli, G., Ferrari, B., Alberti, M., Mikovic, D., Noris, M., Wijmenga, C., Peyvandi, F., Rinaldi, E., Melpignano, A., Campus, S., Podda, R. A., Caria, C., Caddori, A., Di Francesco, E., Giuffrida, G., Agostini, V., Roncarati, U., Mannarella, C., Fragasso, A., Podda, G. M., Bertinato, E., Cerbone, A. M., Tufano, A., Loffredo, G., Poggi, V., Pizzuti, M., Re, G., Ronchi, M., Codeluppi, K., Facchini, L., De Fanti, A., Amarri, S., Trisolini, S. M., Capria, S., Aprile, L., Defina, M., and Ceru, S.
Subjects: 0301 basic medicine, Male, genetic association studies, Genome-wide association study, Autoimmunity, 030204 cardiovascular system & hematology, DISEASE, 0302 clinical medicine, Risk Factors, HLA-DQ beta-Chains, thrombotic thrombocytopenic purpura, POPULATION, GENE-EXPRESSION, education.field_of_study, CLASSICAL HLA ALLELES, Principal Component Analysis, FACTOR-CLEAVING PROTEASE, genetic association studie, Chromosome Mapping, Hematology, Middle Aged, ADAMTS13, Europe, risk factor, Italy, Female, SNPs, Adult, Thrombotic microangiopathy, Genotype, Population, Thrombotic thrombocytopenic purpura, SNP, Single-nucleotide polymorphism, Human leukocyte antigen, Biology, Polymorphism, Single Nucleotide, 03 medical and health sciences, human leukocyte antigen, medicine, HODGKINS LYMPHOMA, Humans, Genetic Predisposition to Disease, GENOME-WIDE ASSOCIATION, education, Alleles, Autoantibodies, Acquired Thrombotic Thrombocytopenic Purpura, Purpura, Thrombotic Thrombocytopenic, medicine.disease, RISK LOCI, 030104 developmental biology, Case-Control Studies, Immunology, HEMOLYTIC-UREMIC SYNDROME
Abstract: Essentials Genetic predisposition to acquired thrombotic thrombocytopenic purpura (aTTP) is mainly unknown. Genetic risk factors for aTTP were studied by Immunochip analysis and replication study. Human leukocyte antigen (HLA) variant rs6903608 conferred a 2.5-fold higher risk of developing aTTP. rs6903608 and HLA-DQB1*05:03 may explain most of the HLA association signal in aTTP. Click to hear Dr Cataland's presentation on acquired thrombotic thrombocytopenic purpura. Summary: Background Acquired thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening thrombotic microangiopathy associated with the development of autoantibodies against the von Willebrand factor-cleaving protease ADAMTS-13. Similarly to what has been found for other autoimmune disorders, there is evidence of a genetic contribution, including the association of the human leukocyte antigen (HLA) class II complex with disease risk. Objective To identify novel genetic risk factors in acquired TTP. Patients/Methods We undertook a case–control genetic association study in 190 European-origin TTP patients and 1255 Italian healthy controls by using the Illumina Immunochip. Replication analysis in 88 Italian cases and 456 controls was performed with single-nucleotide polymorphism (SNP) TaqMan assays. Results and conclusion We identified one common variant (rs6903608) located within the HLA class II locus that was independently associated with acquired TTP at genome-wide significance and conferred a 2.6-fold increased risk of developing a TTP episode (95% confidence interval [CI] 2.02–3.27, P = 1.64 × 10−14). We also found five non-HLA variants mapping to chromosomes 2, 6, 8 and X that were suggestively associated with the disease: rs9490550, rs115265285, rs5927472, rs7823314, and rs1334768 (nominal P-values ranging from 1.59 × 10−5 to 7.60 × 10-5). Replication analysis confirmed the association of HLA variant rs6903608 with acquired TTP (pooled P = 3.95 × 10-19). Imputation of classic HLA genes followed by stepwise conditional analysis revealed that the combination of rs6903608 and HLA-DQB1*05:03 may explain most of the HLA association signal in acquired TTP. Our results refined the association of the HLA class II locus with acquired TTP, confirming its importance in the etiology of this autoimmune disease.
Published: 2016

34. On the RR Lyrae Stars in Globulars. IV. ω Centauri Optical UBVRI Photometry

Author: Jillian R. Neeley, M. Fabrizio, R. da Silva, A. Di Cecco, P. Prada-Moroni, Marco Castellani, R. F. Stellingwerf, Elena Valenti, R. Buonanno, L. M. Freyhammer, S. Marinoni, Scilla Degl'Innocenti, J. Lub, Barry F. Madore, Massimo Dall'Ora, Noriyuki Matsunaga, S. E. Persson, G. Giuffrida, Peter B. Stetson, Marcella Marconi, Adriano Pietrinferni, I. Ferraro, V. F. Braga, Annalisa Calamida, Alistair R. Walker, Giuseppe Bono, M. Marengo, Giuliana Fiorentino, M. Monelli, Emanuele Tognelli, A. M. Piersimoni, Wendy L. Freedman, G. Iannicola, L. Pulone, ITA, USA, GBR, DEU, ESP, CHL, JPN, and NLD
Subjects: Physics, stars: variables: RR Lyrae, globular clusters: individual (omega Cen), stars: distances, stars: horizontal-branch, 010504 meteorology & atmospheric sciences, Settore FIS/05, Astrophysics::High Energy Astrophysical Phenomena, Astronomy and Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, RR Lyrae variable, Astrophysics - Astrophysics of Galaxies, 01 natural sciences, Photometry (astronomy), Astrophysics - Solar and Stellar Astrophysics, Space and Planetary Science, 0103 physical sciences, Astrophysics::Solar and Stellar Astrophysics, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, 0105 earth and related environmental sciences
Abstract: New accurate and homogeneous optical UBVRI photometry has been obtained for variable stars in the Galactic globular $\omega$ Cen (NGC 5139). We secured 8202 CCD images covering a time interval of 24 years and a sky area of 84x48 arcmin. The current data were complemented with data available in the literature and provided new, homogeneous pulsation parameters (mean magnitudes, luminosity amplitudes,periods) for 187 candidate $\omega$ Cen RR Lyrae (RRLs). Among them we have 101 RRc (first overtone), 85 RRab (fundamental) and a single candidate RRd (double-mode) variables. Candidate Blazhko RRLs show periods and colors that are intermediate between RRc and RRab variables, suggesting that they are transitional objects. The comparison of the period distribution and of the Bailey diagram indicates that RRLs in $\omega$ Cen show a long-period tail not present in typical Oosterhoff II (OoII) globulars. The RRLs in dwarf spheroidals and in ultra faint dwarfs have properties between Oosterhoff intermediate and OoII clusters. Metallicity plays a key role in shaping the above evidence. These findings do not support the hypothesis that $\omega$ Cen is the core remnant of a spoiled dwarf galaxy. Using optical Period-Wesenheit relations that are reddening-free and minimally dependent on metallicity we find a mean distance to $\omega$ Cen of 13.71$\pm$0.08$\pm$0.01 mag (semi-empirical and theoretical calibrations). Finally, we invert the I-band Period-Luminosity-Metallicity relation to estimate individual RRLs metal abundances. The metallicity distribution agrees quite well with spectroscopic and photometric metallicity estimates available in the literature., Comment: AJ, accepted
Published: 2016

35. Studying the evolution of AGB stars in the Gaia epoch

Author: Marco Castellani, D. A. García-Hernández, S. Marinoni, F. Dell'Agli, M. Di Criscienzo, P. M. Marrese, G. Giuffrida, Olga Zamora, and Paolo Ventura
Subjects: Physics, Research groups, 010308 nuclear & particles physics, Epoch (astronomy), Metallicity, Astrophysics::High Energy Astrophysical Phenomena, Astronomy, FOS: Physical sciences, Astronomy and Astrophysics, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, Interstellar medium, Stars, Astrophysics - Solar and Stellar Astrophysics, Space and Planetary Science, Nucleosynthesis, 0103 physical sciences, Asymptotic giant branch, Astrophysics::Solar and Stellar Astrophysics, Production (computer science), Astrophysics::Earth and Planetary Astrophysics, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, Solar and Stellar Astrophysics (astro-ph.SR)
Abstract: We present asymptotic giant branch (AGB) models of solar metallicity, to allow the interpretation of observations of Galactic AGB stars, whose distances should be soon available after the first release of the Gaia catalogue. We find an abrupt change in the AGB physical and chemical properties, occurring at the threshold mass to ignite hot bottom burning,i.e. $3.5M_{\odot}$. Stars with mass below $3.5 M_{\odot}$ reach the C-star stage and eject into the interstellar medium gas enriched in carbon , nitrogen and $^{17}O$. The higher mass counterparts evolve at large luminosities, between $3\times 10^4 L_{\odot}$ and $10^5 L_{\odot}$. The mass expelled from the massive AGB stars shows the imprinting of proton-capture nucleosynthesis, with considerable production of nitrogen and sodium and destruction of $^{12}C$ and $^{18}O$. The comparison with the most recent results from other research groups are discussed, to evaluate the robustness of the present findings. Finally, we compare the models with recent observations of galactic AGB stars, outlining the possibility offered by Gaia to shed new light on the evolution properties of this class of objects., Comment: 21 pages, 11 figure, 3 tables, accepted for publication in MNRAS (2016 July 11)
Published: 2016
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36. Vascular reconstruction in monolateral dual kidney transplantation with multiple arteries

Author: G. Giuffrida, Massimiliano Veroux, Nunzia Sinagra, Pierfrancesco Veroux, Burcin Ekser, A. Leonardi, and Alessia Giaquinta
Subjects: Transplantation, medicine.medical_specialty, Kidney, Dual kidney transplantation, business.industry, Anastomosis, Expanded Criteria Donor, medicine.disease, Inferior vena cava, Surgery, medicine.anatomical_structure, medicine.vein, Vascular reconstruction, cardiovascular system, medicine, Radiology, business, Survival rate, Kidney transplantation
Abstract: We report the results of monolateral dual kidney transplantation with grafts with multiple arteries. Among the 42 monolateral DKT performed in a seven-yr period, 12 (28.5%) patients received renal grafts with multiple arteries. In six patients, the accessory arteries were anastomosed end-to-side or side-to-side on the aortic patch. In six patients, with three or more accessory arteries, a vascular reconstruction with an inferior vena cava patch was performed, before implanting the kidney. There were no intraoperative complications in the entire series, and there were no immediate vascular complications. Vascular reconstruction of kidneys with multiple arteries may be performed safely even in monolateral dual kidney transplantation. Inferior vena cava may be an attractive alternative in vascular reconstruction for kidneys with multiple arteries.
Published: 2011

37. Magnetic Resonance With Diffusion-Weighted Imaging in the Evaluation of Transplanted Kidneys: Preliminary Findings

Author: Stefano Palmucci, Pierfrancesco Veroux, Giovanni Failla, Giovanni Carlo Ettorre, D. Zerbo, Massimiliano Veroux, N. Sinagra, Pietro Milone, Letizia Mauro, and G. Giuffrida
Subjects: Adult, Male, Time Factors, Population, Renal function, Pilot Projects, Kidney, Normal renal function, Predictive Value of Tests, medicine, Humans, Effective diffusion coefficient, Renal Insufficiency, education, Aged, Transplantation, education.field_of_study, medicine.diagnostic_test, Receiver operating characteristic, business.industry, Magnetic resonance imaging, Middle Aged, Kidney Transplantation, Diffusion Magnetic Resonance Imaging, Treatment Outcome, Italy, ROC Curve, Creatinine, Mann–Whitney U test, Female, Surgery, business, Nuclear medicine, Biomarkers, Glomerular Filtration Rate, Diffusion MRI
Abstract: Background. The aim of this study was to compare values of apparent diffusion coefficient (ADC) and diffusion (D) with renal function indexes, in a population of kidney transplant recipients who underwent magnetic resonance with diffusion-weighted imaging (DWI) of the transplanted graft. Materials and Methods. We studied 21 patients using a 1.5-Tesla magnetic resonance; DWI sequences were acquired with several b-values. Patients were divided into 3 groups by their creatinine clearance values: group A, clearance >60 mL/min; group B, clearance >30 and ≤60 mL/min; and group C, clearance ≤30 mL/min. ADCs values between groups were compared using the Mann-Whitney U test. Receiver operating characteristic (ROC) curves were created for prediction of normal renal function (group A) and renal failure (group C). Results. Comparing mean values of ADC between groups A and C, we observed a difference (P = 0.0012), with higher values in group A. Regarding mean values of D, we observed a difference between groups A and C (P = 0.022). In the comparison between contiguous groups, we observed no difference for ADC and D values. In the prediction of normal clearance values (group A), ROC curve showed an area under curve (AUC) of 0.861, with a sensitivity of 88.89% and specificity of 75% using a threshold ADC value ≥2.1 × 10- 3 mm 2 /sec. For prediction of normal clearance values (group A), ROC curve showed an AUC of 0.787, with a sensitivity of 77.8% and specificity of 83.3% using a threshold D value ≥2.3 × 10- 3 mm 2 /sec. Conclusion. Although studies with a larger number of patients are needed, DWI represents a promising tool for noninvasive assessment of renal function. An ADC ≥ 2.1 × 10 -3 mm 2 /sec and a D ≥ 2.3 × 10- 3 mm 2 /sec may be used as a threshold for predicting normal clearance.
Published: 2011

38. Two-as-one Monolateral Dual Kidney Transplantation

Author: Massimiliano Veroux, G. Giuffrida, Alessandro Cappellani, Stefano Palmucci, Pietro Caglià, Massimiliano Sorbello, Pierfrancesco Veroux, and Lidia Puzzo
Subjects: Adult, Male, Nephrology, medicine.medical_specialty, Urology, Urinary system, Renal function, Kidney, Cold Ischemia Time, Graft, Internal medicine, medicine, Humans, Kidney transplantation, Aged, Transplantation, business.industry, Mortality rate, Middle Aged, medicine.disease, Kidney Transplantation, Surgery, medicine.anatomical_structure, Female, Ureteral Stricture, business
Abstract: Objectives Dual kidney transplantation (DKT) of marginal kidneys could offer transplant candidates a very satisfactory kidney transplantation in terms of renal function. However, DKT might be considered a major surgical procedure and, in older recipients, has a potentially greater risk of surgical complications compared with single kidney transplantation. Because of these findings, some transplant centers have replaced the classic bilateral placement of 2 kidneys with the monolateral placement of both kidneys. Methods In a group of 35 DKTs performed during a 5-year period, we applied a new technique of monolateral placement of DKT in 10 recipients. In these 10 patients, the arteries and veins of the 2 kidneys were joined through a running suture, and the joined kidneys were anastomosed into the external iliac vessels in the recipient. Results The delayed graft function rate was 20%. No surgical complications developed in the entire series. One patient experienced late rejection with ureteral stricture. The graft and patient survival rate at a median follow-up of 30 months was 90%. Conclusions To reduce the surgical risk and morbidity rate, the monolateral placement of both kidneys seems the safest method to perform DKT. The joined monolateral DKT, by reducing the cold ischemia time and the surgical trauma, could represent a step forward in the delicate treatment of these patients.
Published: 2011

39. Visceral leishmaniasis in the early post-transplant period after kidney transplantation: clinical features and therapeutic management

Author: D. Zerbo, G. Giuffrida, Massimiliano Veroux, B. Cacopardo, N. Sinagra, Tiziano Tallarita, Pierfrancesco Veroux, A. Giaquinta, and Daniela Corona
Subjects: Transplantation, medicine.medical_specialty, business.industry, Leishmaniasis, Retrospective cohort study, medicine.disease, Pancytopenia, Surgery, surgical procedures, operative, Infectious Diseases, Visceral leishmaniasis, Internal medicine, Amphotericin B, medicine, Complication, business, Kidney transplantation, medicine.drug
Abstract: Visceral leishmaniasis (VL) is a rare complication of kidney transplantation, with
Published: 2010

40. Sirolimus-Based Immunosuppression in Kidney Transplantation for Type 2 Diabetic Nephropathy

Author: D. Zerbo, G. Giuffrida, Tiziano Tallarita, Pierfrancesco Veroux, Massimiliano Veroux, Daniela Corona, M. Macarone, A. Giaquinta, M. Gagliano, D. Vizcarra, and Massimiliano Sorbello
Subjects: medicine.medical_specialty, Urology, medicine.medical_treatment, Population, Type 2 diabetes, Diabetic nephropathy, Diabetes mellitus, Humans, Medicine, Diabetic Nephropathies, education, Kidney transplantation, Retrospective Studies, Immunosuppression Therapy, Sirolimus, education.field_of_study, business.industry, Immunosuppression, Middle Aged, medicine.disease, Kidney Transplantation, Tacrolimus, Surgery, surgical procedures, operative, Diabetes Mellitus, Type 2, business, Immunosuppressive Agents, medicine.drug
Abstract: Introduction: Kidney transplantation is the best replacement therapy of type 2 diabetic patients and recently similar graft and patient survival between diabetic and nondiabetic recipients has been reported. However, standard immunosuppressive protocols are lacking. We present our experience with sirolimus-based immunosuppression in a population of 24 type 2 diabetic patients who underwent a kidney transplantation. Patients and Methods: From January 2001 to December 2006, 396 kidney transplantations were performed. Twenty-four patients had type 2 diabetes mellitus as a cause of end-stage renal disease. They were randomized in two groups: thirteen patients (group A) received an immunosuppressive treatment with sirolimus, low-dose tacrolimus and steroids, while 11 patients (group B) received sirolimus, mycophenolate mofetil and steroids. Results: Clinical characteristics were similar between the two groups. A slightly better kidney functionality was observed in group B patients. There were neither acute rejection episodes nor severe infectious complications in both groups. One patient in each group underwent a foot amputation. Graft and patient survival was 100% for both groups at a median follow-up of 29 months. Conclusions: Sirolimus-based immunosuppression is safe and efficacious in type 2 diabetic patients who underwent a kidney transplantation, allowing a better glucose metabolism control.
Published: 2010

41. Environmental health risk communication in the case 'Terra dei Fuochi': content analysis of online newspaper articles

Author: M, Barchitta, S, Fragapane, A, Quattrocchi, M T, Consoli, G, Giuffrida, C, Pennisi, and A, Agodi
Subjects: Publishing, Risk, Health Communication, Italy, Hazardous Waste Sites, Newspapers as Topic, Environmental Health, Retrospective Studies
Abstract: The aim of the study is to evaluate the way in which information is conveyed by one of the major national newspapers, in its online version, Repubblica.it, about health risks associated with the "Terra dei Fuochi".A retrospective systematic search in the online newspaper database was carried out for articles published from 1st January through 13th May 2014. The keyword used was "Terra dei Fuochi". A corpus, containing all articles included, was built in order to perform content analysis and text-mining using the T-LAB software, together with a critical interpretation. The co-occurrence analysis was performed using the keywords: environment, prevention, waste , risk and science.A total of 211 articles were retrieved, but only 188 articles met the inclusion criteria and were included in the analysis. The section of publication with the largest number of articles was represented by Repubblica Napoli edition with 50% of articles, whereas, only 2% of articles were included in the Environment section, and no article has been placed in the Health section. The most occurring lemmas were: waste, Naples, President, environmental - environment and health. Lemmas as disaster, drama, alarm and fear occur with medium frequency. Among the lemmas with less occurrence there were: remediation, cancer, people, information and recycle. However, terms as communication and risk management were absent.This study contributes to our understanding of how environmental health risks associated with the "Terra dei Fuochi" issue are presented by the newspapers to the public, which has implications for how the public may learn about risk management information.
Published: 2015

42. Determinazione per via spettroscopica di una scala di idrofilicità per materiali molecular sieves

Author: BALLARINI, NICOLA, CAVANI, FABRIZIO, DEGLI ESPOSTI, ELISA, R. Ramaioli, G. Giuffrida, N. Ballarini, F. Cavani, E. Degli Esposti, R. Ramaioli, and G. Giuffrida
Published: 2008

43. Contamination of Preservation Fluid in Kidney Transplantation: Single-Center Analysis

Author: D. Zerbo, V. Scriffignano, Massimiliano Veroux, G. Giuffrida, Daniela Corona, N. Sinagra, Floriana Gona, M. Gagliano, Massimiliano Sorbello, Laura Parrinello, A. Sciacca, Pierfrancesco Veroux, Pietro Caglià, Tiziano Tallarita, A. Giaquinta, and S. Oliveri
Subjects: Male, medicine.medical_specialty, Antifungal Agents, medicine.drug_class, Recombinant Fusion Proteins, medicine.medical_treatment, Organ Preservation Solutions, Antibiotics, Tazobactam, Basiliximab, medicine, Humans, Fluconazole, Kidney transplantation, Antilymphocyte Serum, Candida, Retrospective Studies, Transplantation, Bacteria, business.industry, Antibodies, Monoclonal, Middle Aged, Contamination, medicine.disease, Kidney Transplantation, Nephrectomy, Surgery, Female, Drug Contamination, business, Immunosuppressive Agents, Piperacillin, medicine.drug
Abstract: Introduction Contamination of preservation fluid is common, with a reported incidence of 2.2% to 28.0%, and may be a major cause of early morbidity after transplantation. Herein, we report our experience with routine examination of preservation fluid collected just before implantation, focusing on the rate of contamination and the clinical consequences to recipients. Materials and Methods We analyzed 62 samples of preservation fluid for microbial and fungal contamination. Results Twenty-four samples (38.7%) were contaminated with at least 1 organism. Bacterial contamination alone was observed in 18 samples; all patients received prophylactic treatment with intravenous piperacillin/tazobactam, 4.5 g/d for 10 days, without clinical sequelae. Six samples were contaminated with Candida species; all patients received prophylactic treatment with fluconazole, 100 mg/d for 3 months. One patient developed reversible acute renal failure due to ureteral obstruction by fungus balls at 30 days after transplantation. Conclusion Contamination of preservation fluid occurs frequently after kidney transplantation. Bacterial contamination evolved without symptoms in most patients treated with prophylactic antibiotic therapy. Fungal contamination may be potentially life-threatening. However, graft nephrectomy is not mandatory if the involved Candida species is identified correctly and appropriate antifungal therapy is rapidly prescribed.
Published: 2010

44. [Untitled]

Author: F. Frascarelli, P. Campa, A. L'Abbate, J. Dalle Mule, A. Lacchè, M. Benigno, S. Melorio, M. Campana, M. Fantinel, M. Del Pinto, F. De Pascale, Massimo F Piepoli, A. Lizzardo, G. Tartarini, A. Zanocco, M. Mastursi, E. Giovannini, Massimo Chiariello, A. Oddone, F. Lattanzi, G. Pulignano, D. Di Donato, L. Liguori, Paolo Spallarossa, V. De Rosa, N. Mininni, P. Morosetti, W. Rauhe, M. Sorino, S. Mandorla, R. Gattobigio, M. Orlandi, M. Giasi, B. Reisenhofer, A. Palumbo, L. Ciarcia, A. Zoni, D. Mondanelli, S. Polimeno, B. Del Salvatore, G. Montana, Francesco Fedele, Clara Carpeggiani, M. E. Petrillo, M. Mazzella, Alessandro Boccanelli, G. Licciardello, Francesco Barillà, G. R. Cristinziani, L. Bini, C. Brunelli, M A Losi, G. Moretti, C. Panciroli, Pietro Delise, C. Borgioni, V. Caizzi, Roberto Ferrari, O. Biadi, Silvio Romano, A. Castello, I. De Luca, E. Capponi, A. Rolandi, A. Erlicher, S. Cuomo, G. D'Angelo, A. Battaglia, M. Lo Monaco, Alessandro Capucci, Marco Valerio Mariani, L. Mario, A. Morales, C. Biscosi, P. F. Rossettini, L. Coro, P. Pascotto, L. De Biase, F. Passerini, C. Piscicelli, Quirino Ciampi, A. Boccalatte, P. Bottiglieri, M. Bonaglia, R. P. Dabizzi, E. Zanelli, F. Fusco, G. Bilardo, R. Leghissa, M. G. Mozzato, G. Corsini, Amerigo Giordano, L. Ferraro, A. Zasso, M. Buccolieri, W. Pitscheider, G. Giuffrida, Sandro Betocchi, and D. Zampino
Subjects: Pharmacology, medicine.medical_specialty, business.industry, General Medicine, medicine.disease, Internal medicine, medicine, Perindopril, Cardiology, Heart rate variability, Pharmacology (medical), Myocardial infarction, Cardiology and Cardiovascular Medicine, business, medicine.drug
Published: 2000

45. Acute renal failure due to ureteral obstruction in a kidney transplant recipient withCandida albicanscontamination of preservation fluid

Author: D. Zerbo, Alessandro Cappellani, G. Giuffrida, A. Giaquinta, Pierfrancesco Veroux, Daniela Corona, Tiziano Tallarita, Massimiliano Veroux, and M. Gagliano
Subjects: medicine.medical_specialty, Antifungal Agents, medicine.medical_treatment, Organ Preservation Solutions, Graft function, Pharmacotherapy, Candida albicans, Humans, Medicine, Kidney transplantation, Voriconazole, Transplantation, biology, business.industry, Candidiasis, Acute Kidney Injury, Middle Aged, biology.organism_classification, medicine.disease, Kidney Transplantation, Nephrectomy, Surgery, Kidney transplant recipient, surgical procedures, operative, Infectious Diseases, Preservation fluid, Equipment Contamination, Female, business, Ureteral Obstruction, medicine.drug
Abstract: Reported rates of positive preservation fluid cultures range from 5% to 23%, with fungi accounting for 2-10% of all positive cultures. We report the case of a kidney transplant recipient who received a graft with preservation fluid contaminated by Candida albicans, who developed acute renal failure due to ureteral obstruction by fungus balls. The patient was treated with voriconazole with complete restoration of graft function. This rare clinical entity demonstrates the usefulness of pre-transplant cultures of preservation fluid, in order to identify a group of patients who could benefit from antifungal prophylaxis therapy and thereby prevent the need for graft nephrectomy.
Published: 2009

46. Evaluation of Thyroid Disease in Kidney Transplantation Candidates: Management and Follow-up

Author: Massimiliano Sorbello, Massimiliano Veroux, M. Gagliano, D. Zerbo, Matteo Angelo Cannizzaro, Tiziano Tallarita, Pierfrancesco Veroux, Daniela Corona, D. Vizcarra, V. Scriffignano, G. Giuffrida, and A. Giaquinta
Subjects: Adult, Male, endocrine system, medicine.medical_specialty, Goiter, endocrine system diseases, Adenoma, Urinary system, medicine, Humans, Thyroid Neoplasms, Thyroid cancer, Kidney transplantation, Aged, Retrospective Studies, Transplantation, business.industry, Incidence, Thyroid disease, Thyroid, Middle Aged, medicine.disease, Kidney Transplantation, Carcinoma, Papillary, Surgery, medicine.anatomical_structure, Italy, Kidney Failure, Chronic, Female, Neoplasm Recurrence, Local, business, Follow-Up Studies
Abstract: Introduction. Diagnosis of thyroid disease is fundamental in the evaluation of patients awaiting kidney transplantation. We analyzed the incidence of thyroid disease in patients with end-stage renal disease (ESRD) and evaluated its evolution before and after kidney transplantation. Patients and Methods. Between January 2000 and May 2008, we evaluated 323 candidates for kidney transplantation. In all patients, serum concentrations of free triiodothyronine, free thyroxine, and thyroid-stimulating hormone were determined and a ultrasonography of the neck was performed. Patients with thyroid cancer were considered eligible for kidney transplantation after at least 2 years since treatment. Results. One-hundred-four patients with ESRD (44%) had functional or morphologic changes in the thyroid gland. Forty-one patients (17.4%) underwent fine-needle aspiration cytology; 3 demonstrated showed papillary carcinoma; 3, follicular adenomas; 8, uncertain cytologic lesions; and 27, a nodular goiter. Seventeen patients underwent surgery. Six of 11 patients with thyroid cancer underwent transplantation: two patients underwent laterocervical lymph node dissection because of local recurrence within 2 years after successful transplantation; the other 4 patients are alive with a functioning graft. Of the 184 transplant recipients, 10 underwent surgery to treat thyroid disease: 8 with multinodular goiter, 1 with micropapillary carcinoma, and 1 with follicular adenoma. All 10 patients are alive with a well-functioning graft and no signs of disease recurrence. Conclusions. Thyroid diseases are common in patients with ESRD. Early diagnosis and treatment significantly decreased morbidity and mortality in patients awaiting transplantation.
Published: 2009

47. Mugwort-fennel-allergy-syndrome associated with sensitization to an allergen homologous to Api g 5

Author: F, Borghesan, G, Mistrello, S, Amato, M G, Giuffrida, D, Villalta, and R, Asero
Subjects: Adult, Male, Proteomics, Sequence Homology, Amino Acid, Molecular Sequence Data, Rhinitis, Allergic, Seasonal, Enzyme-Linked Immunosorbent Assay, Syndrome, Antigens, Plant, Cross Reactions, Immunoglobulin E, Molecular Weight, Young Adult, Artemisia, Foeniculum, Humans, Pollen, Amino Acid Sequence, Databases, Protein, Biomarkers, Food Hypersensitivity, Plant Proteins
Abstract: The cross-reactive allergen responsible for the so called "mugwort-celery-spice-syndrome", a pollen-food allergy that occurs in a minority of mugwort pollen-allergic patients, is still undefined.To identify the allergen responsible for the cross-reactivity between mugwort pollen and plant-derived foods.The serum from one index patient with both fennel and mugwort pollen allergy was used to identify IgE-reactive allergens by direct ELISA and Immunoblot analysis. Cross-reactivity between mugwort pollen and fennel was checked by cross-inhibition experiments. Fennel and mugwort allergens selected on the basis of IgE reactivity and inhibition tests were excised from SDS-PAGE gels and microsequenced. The amino acid sequences obtained were used to screen the NCBI database using the protein BLAST software.On ELISA inhibition experiments, serum absorption with fennel extract completely inhibited the IgE response to mugwort. On immmunoblot analysis periodate treatment caused the disappearance of all bands of IgE reactivity except one at about 60 kDa. The 60 kDa bands from both mugwort and fennel PAGE-SDS gels revealed the presence of distinct proteins. The N-terminal amino acid sequencing gave the same major amino acid sequence corresponding to an Api g 5-like allergen. The MS/MS spectra were analyzed and a provided evidence of a fennel-specific protein with sequence similarity to phosphoglyceromutase from Apium graveolens.A 60 kDa allergen, highly homologous to Api g 5, was recognized in fennel by patient's IgE. Inhibition experiments showed a high degree of cross-reactivity between this fennel allergen and the homologous mugwort pollen allergen. This allergen might be responsible for the mugwort-celery-spice syndrome.
Published: 2013

48. The Concept of Self and Emotional Involvement in Living Kidney Donation: A Psychometric Investigation

Author: G. Giuffrida, C. De Pasquale, Pierfrancesco Veroux, A. Giaquinta, Daniela Corona, M. Gagliano, D. Zerbo, Sebastiano Cimino, M.L. Pistorio, Massimiliano Veroux, and N. Sinagra
Subjects: Male, Transplantation, Tissue and Organ Procurement, Psychometrics, media_common.quotation_subject, Emotions, Kidney donation, medicine.disease, Kidney Transplantation, Developmental psychology, Donation, medicine, Living Donors, Personality, Humans, Surgery, Female, Big Five personality traits, Psychology, Kidney transplantation, media_common
Abstract: Objective The aim of our study was to analyze, from a psychological point of view, living kidney donor personality, examining a sample of 18 living kidney donors. Patients and methods The personality study was performed using The Millon Clinical Multiaxial Inventory-III in 18 potential kidney donors, 6 of whom were genetically and 12 emotionally related individuals. Results Our study showed the presence of narcissistic, histrionic, and obsessive-compulsive personality traits in living kidney donors. Conclusions It is necessary to explore the development of motivation for living donation in order to achieve and maintain a harmonious relationship with the recipient while respecting their individuality.
Published: 2013

49. Bromine monoxide/sulphur dioxide ratios in relation to volcanological observations at Mt. Etna 2006–2009

Author: N. Bobrowski and G. Giuffrida
Abstract: Over a three year period, from 2006 to 2009, frequent scattered sun light DOAS measurements were conducted at Mt. Etna in a distance of around six kilometres downwind from the summit craters. During the same period and in addition to these measurements, volcanic observations were made by regularly visiting various parts of Mt. Etna. Results from these measurements and observations are presented and their relation is discussed. The focus of the investigation is the bromine monoxide/sulphur dioxide (BrO/SO2) ratio, and its variability in relation to volcanic processes. That the halogen/sulphur ratio can serve as a precursor or indicator for the onset of eruptive activity was already proposed by earlier works (e.g. Noguchi and Kamiya, 1963; Menyailov, 1975; Pennisi and Cloarec, 1998; Aiuppa, 2002). However, there is still a limited understanding today because of the complexity with which halogens are released, depending on magma composition and degassing conditions. Our understanding of these processes is far from complete, for example of the rate and mechanism of bubble nucleation, growth and ascent in silicate melts (Carroll and Holloway, 1994), the halogen vapour-melt partitioning and the volatile diffusivity in the melt (Aiuppa et al., 2009). With this study we aim to add one more piece to the puzzle of what halogen/sulphur ratios might tell about volcanic activities. Our data set shows an increase of the BrO/SO2 ratio several weeks prior to an eruption, followed by a decline before and during the initial phase of eruptive activities. Towards the end of activity or short afterwards, the ratio increases to baseline values again and remains more or less constant during quiet phases. To explain the observed evolution of the BrO/SO2 ratio, a first empirical model is proposed. This model suggests that bromine, unlike chlorine and fluorine, is less soluble in the magmatic melt than sulphur. By using the DOAS method to determine SO2, we actually observe most of the emitted sulphur of Mt. Etna. Regarding bromine however, we are aware that by determining only the bromine monoxide (BrO) radical we might just observe a small or even a variable fraction of the total emitted bromine. Therefore we present first studies to justify the assumption that despite the disadvantage just mentioned, the BrO/SO2 ratio can nevertheless serve as a new parameter to indicate the state of a volcano, when measurements are conducted under certain, but rather convenient conditions.
Published: 2012

50. Short Communication

Author: A. Cantisani, Maria Cavaletto, Amedeo Conti, G Giuffrida, and Lorenzo Napolitano
Subjects: animal structures, Chromatography, Biochemistry, Chemistry, Protein subunit, Casein, Protein purification, Alpha (ethology), Ultracentrifuge, Beta (finance), Peptide sequence, Homology (biology)
Abstract: Casein components of human milk are generally reported to belong to the beta- and kappa-groups. In this research human casein fraction was obtained from pooled mature milk, either by ultracentrifugation or by acid precipitation. In both cases a minor component with a slightly higher mobility in SDS-PAGE than beta-casein was identified. The protein was purified to homogeneity, the N-terminal sequence of the first 14 amino acid residues of this new human casein subunit shows a high degree of homology with the alpha s1-casein sequences from other species.
Published: 1994

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