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1,550 results on '"A. Fuglsang-Frederiksen"'

1. Evidence-based recommendations for examination and diagnostic strategies of polyneuropathy electrodiagnosis

Author

H. Tankisi, K. Pugdahl, S. Beniczky, H. Andersen, and A. Fuglsang-Frederiksen

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

The purpose of this report is to recommend evidence-based strategies for polyneuropathy (PNP) electrodiagnosis based on a large cohort of patients examined prospectively. Nerve conduction studies (NCS) of bilateral tibial, peroneal and sural nerves, the latter with both near-nerve-technique (NNT) and surface recordings, were done in 313 patients with clinically suspected PNP. Bilateral dorsal sural and medial plantar nerves, and unilateral median and ulnar nerves were further examined in a subgroup of patients. The final clinical diagnosis retrieved from the patientś medical records 1–6 years after the neurophysiological investigation served as diagnostic reference standard. The clinical follow-up diagnosis confirmed PNP in 219 patients. The tibial nerve was the most sensitive nerve (75%), with prolonged tibial F-wave as the most sensitive parameter (72%). Sural NNT recordings were more sensitive (66%) than surface recordings (49%) (p

Published
2019
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2. Threshold tracking transcranial magnetic stimulation and neurofilament light chain as diagnostic aids in ALS

Author

Anna B. Jacobsen, Hugh Bostock, James Howells, Bülent Cengiz, Gintaute Samusyte, Martin Koltzenburg, Hossein Pia, Anders Fuglsang‐Frederiksen, Jakob Blicher, Izabella Obál, Henning Andersen, and Hatice Tankisi

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Objective There is a need for sensitive biomarkers in amyotrophic lateral sclerosis (ALS), to enable earlier diagnosis and to help assess potential treatments. The main objective of this study was to compare two potential biomarkers, threshold‐tracking short‐interval cortical inhibition (T‐SICI), which has shown promise as a diagnostic aid, and neurofilament light chains (NfL). Methods Ninety‐seven patients with ALS (mean age 67.1 ± 11.5 years) and 53 ALS mimics (aged 62.4 ± 12.9) were included. Mean disease duration was 14 months ±14.1. Patients were evaluated with revised ALS functional rating score (ALSFRS‐R), Penn upper motor neuron score (UMNS), muscle strength using the Medical Research Council (MRC) score and examined with T‐SICI, quantitative electromyography (EMG), and NfL measured in spinal fluid. Results NfL increased with increasing UMNS (rho = 0.45, p = 8.2 × 10−6) whereas T‐SICI at 2.5 ms paradoxically increased toward normal values (rho = 0.53, p = 1.9 × 10−7). However, these two measures were uncorrelated. Discrimination between ALS patients and mimics was best for NfL (area under ROC curve 0.842, sensitivity 84.9%, specificity 83.5%), compared with T‐SICI (0.675, 39.6%, 91.8%). For the patients with no UMN signs, NfL also discriminated best (0.884, 89.3%, 82.6%), compared with T‐SICI (0.811, 71.4%, 82.6%). However, when combining NfL and T‐SICI, higher AUCs of 0.854 and 0.922 and specificities of 93.8 and 100 were found when considering all patients and patients with no UMN signs, respectively. Interpretation Both T‐SICI and NfL correlated with UMN involvement and combined, they provided a strong discrimination between ALS patients and ALS mimics.

Published
2024
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3. Estimating motor unit numbers from a CMAP scan: Repeatability study on three muscles at 15 centres

Author

Sørensen, D.M., Bostock, H., Abrahao, A., Alaamel, A., Alaydin, H.C., Ballegaard, M., Boran, E., Cengiz, B., de Carvalho, M., Dunker, Ø., Fuglsang-Frederiksen, A., Graffe, C.C., Jones, K.E., Kallio, M., Kalra, S., Krarup, C., Krøigård, T., Liguori, R., Lupescu, T., Maitland, S., Matamala, J.M., Moldovan, M., Moreno-Roco, J., Nilsen, K.B., Phung, L., Santos, M.O., Themistocleous, A.C., Uysal, H., Vacchiano, V., Whittaker, R.G., Zinman, L., and Tankisi, H.

Published
2023
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5. Assessing inter-rater reproducibility in MScanFit MUNE in a 6-subject, 12-rater “Round Robin” setup

Author

Sørensen, Daniel Mosgaard, Bostock, Hugh, Ballegaard, Martin, Fuglsang-Frederiksen, Anders, Graffe, Carolina Canillo, Grötting, Arnstein, Jones, Kelvin, Kallio, Mika, Krarup, Christian, Krøigård, Thomas, Lupescu, Tudor, Maitland, Stuart, Moldovan, Mihai, Nilsen, Kristian Bernhard, Pugdahl, Kirsten, Santos, Miguel Oliveira, Themistocleous, Andreas Constantinos, Zlateva, Suzana Slavica, Ööpik, Merle, and Tankisi, Hatice

Published
2022
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11. Standards of instrumentation of EMG

Author

Tankisi, Hatice, Burke, David, Cui, Liying, de Carvalho, Mamede, Kuwabara, Satoshi, Nandedkar, Sanjeev D., Rutkove, Seward, Stålberg, Erik, van Putten, Michel J.A.M., and Fuglsang-Frederiksen, Anders

Published
2020
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15. Threshold tracking transcranial magnetic stimulation and neurofilament light chain as diagnostic aids in ALS.

Author

Jacobsen, Anna B., Bostock, Hugh, Howells, James, Cengiz, Bülent, Samusyte, Gintaute, Koltzenburg, Martin, Pia, Hossein, Fuglsang‐Frederiksen, Anders, Blicher, Jakob, Obál, Izabella, Andersen, Henning, and Tankisi, Hatice

Subjects
TRANSCRANIAL magnetic stimulation, AMYOTROPHIC lateral sclerosis, CYTOPLASMIC filaments, CEREBROSPINAL fluid, MOTOR neurons
Abstract

Objective: There is a need for sensitive biomarkers in amyotrophic lateral sclerosis (ALS), to enable earlier diagnosis and to help assess potential treatments. The main objective of this study was to compare two potential biomarkers, threshold‐tracking short‐interval cortical inhibition (T‐SICI), which has shown promise as a diagnostic aid, and neurofilament light chains (NfL). Methods: Ninety‐seven patients with ALS (mean age 67.1 ± 11.5 years) and 53 ALS mimics (aged 62.4 ± 12.9) were included. Mean disease duration was 14 months ±14.1. Patients were evaluated with revised ALS functional rating score (ALSFRS‐R), Penn upper motor neuron score (UMNS), muscle strength using the Medical Research Council (MRC) score and examined with T‐SICI, quantitative electromyography (EMG), and NfL measured in spinal fluid. Results: NfL increased with increasing UMNS (rho = 0.45, p = 8.2 × 10−6) whereas T‐SICI at 2.5 ms paradoxically increased toward normal values (rho = 0.53, p = 1.9 × 10−7). However, these two measures were uncorrelated. Discrimination between ALS patients and mimics was best for NfL (area under ROC curve 0.842, sensitivity 84.9%, specificity 83.5%), compared with T‐SICI (0.675, 39.6%, 91.8%). For the patients with no UMN signs, NfL also discriminated best (0.884, 89.3%, 82.6%), compared with T‐SICI (0.811, 71.4%, 82.6%). However, when combining NfL and T‐SICI, higher AUCs of 0.854 and 0.922 and specificities of 93.8 and 100 were found when considering all patients and patients with no UMN signs, respectively. Interpretation: Both T‐SICI and NfL correlated with UMN involvement and combined, they provided a strong discrimination between ALS patients and ALS mimics. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Standardized computer-based organized reporting of EEG: SCORE – Second version

Author

Beniczky, Sándor, Aurlien, Harald, Brøgger, Jan C., Hirsch, Lawrence J., Schomer, Donald L., Trinka, Eugen, Pressler, Ronit M., Wennberg, Richard, Visser, Gerhard H., Eisermann, Monika, Diehl, Beate, Lesser, Ronald P., Kaplan, Peter W., Nguyen The Tich, Sylvie, Lee, Jong Woo, Martins-da-Silva, Antonio, Stefan, Hermann, Neufeld, Miri, Rubboli, Guido, Fabricius, Martin, Gardella, Elena, Terney, Daniella, Meritam, Pirgit, Eichele, Tom, Asano, Eishi, Cox, Fieke, van Emde Boas, Walter, Mameniskiene, Ruta, Marusic, Petr, Zárubová, Jana, Schmitt, Friedhelm C., Rosén, Ingmar, Fuglsang-Frederiksen, Anders, Ikeda, Akio, MacDonald, David B., Terada, Kiyohito, Ugawa, Yoshikazu, Zhou, Dong, and Herman, Susan T.

Published
2017
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37. Estimating motor unit numbers from a CMAP scan:Repeatability study on three muscles at 15 centres

Author

Sørensen, D. M., Bostock, H., Abrahao, A., Alaamel, A., Alaydin, H. C., Ballegaard, M., Boran, E., Cengiz, B., de Carvalho, M., Dunker, Fuglsang-Frederiksen, A., Graffe, C. C., Jones, K. E., Kallio, M., Kalra, S., Krarup, C., Krøigård, T., Liguori, R., Lupescu, T., Maitland, S., Matamala, J. M., Moldovan, M., Moreno-Roco, J., Nilsen, K. B., Phung, L., Santos, M. O., Themistocleous, A. C., Uysal, H., Vacchiano, V., Whittaker, R. G., Zinman, L., Tankisi, H., Sørensen, D. M., Bostock, H., Abrahao, A., Alaamel, A., Alaydin, H. C., Ballegaard, M., Boran, E., Cengiz, B., de Carvalho, M., Dunker, Fuglsang-Frederiksen, A., Graffe, C. C., Jones, K. E., Kallio, M., Kalra, S., Krarup, C., Krøigård, T., Liguori, R., Lupescu, T., Maitland, S., Matamala, J. M., Moldovan, M., Moreno-Roco, J., Nilsen, K. B., Phung, L., Santos, M. O., Themistocleous, A. C., Uysal, H., Vacchiano, V., Whittaker, R. G., Zinman, L., and Tankisi, H.

Abstract

Objective: To assess the repeatability and suitability for multicentre studies of MScanFit motor unit number estimation (MUNE), which involves modelling compound muscle action potential (CMAP) scans. Methods: Fifteen groups in 9 countries recorded CMAP scans twice, 1–2 weeks apart in healthy subjects from abductor pollicis brevis (APB), abductor digiti minimi (ADM) and tibialis anterior (TA) muscles. The original MScanFit program (MScanFit-1) was compared with a revised version (MScanFit-2), designed to accommodate different muscles and recording conditions by setting the minimal motor unit size as a function of maximum CMAP. Results: Complete sets of 6 recordings were obtained from 148 subjects. CMAP amplitudes differed significantly between centres for all muscles, and the same was true for MScanFit-1 MUNE. With MScanFit-2, MUNE differed less between centres but remained significantly different for APB. Coefficients of variation between repeats were 18.0% for ADM, 16.8% for APB, and 12.1% for TA. Conclusions: It is recommended for multicentre studies to use MScanFit-2 for analysis. TA provided the least variable MUNE values between subjects and the most repeatable within subjects. Significance: MScanFit was primarily devised to model the discontinuities in CMAP scans in patients and is less suitable for healthy subjects with smooth scans.

Published
2023

44. Clinical Neurophysiology

Author

Fuglsang-Frederiksen, Anders, Hansen, Peter Orm, Arnold, Wolfgang, editor, Ganzer, Uwe, editor, Lumenta, Christianto B., editor, Di Rocco, Concezio, editor, Haase, Jens, editor, and Mooij, Jan Jakob A., editor

Published
2010
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45. Basics

Author

Lumenta, Christianto B., Zamarro Parra, Joaquín, Espinosa de Rueda Ruiz, Mariano, Parrilla Reverter, Guillermo, Moreno Diéguez, Antonio, Fuglsang-Frederiksen, Anders, Hansen, Peter Orm, Mooij, Jan Jakob A., Journée, H. L., Abrahamsen, Jan, Gjerris, Flemming, Arnold, Wolfgang, editor, Ganzer, Uwe, editor, Lumenta, Christianto B., editor, Di Rocco, Concezio, editor, Haase, Jens, editor, and Mooij, Jan Jakob A., editor

Published
2010
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50. Three different short-interval intracortical inhibition methods in early diagnosis of amyotrophic lateral sclerosis

Author

Hatice Tankisi, Hossein Pia, Kristine Strunge, James Howells, Bülent Cengiz, Gintaute Samusyte, Martin Koltzenburg, Anders Fuglsang-Frederiksen, and Hugh Bostock

Subjects
Early Diagnosis, Neurology, Neural Inhibition/physiology, Amyotrophic Lateral Sclerosis/diagnosis, Humans, Neurology (clinical), Motor Neuron Disease, Evoked Potentials, Motor/physiology, Transcranial Magnetic Stimulation/methods
Abstract

Objectives: To compare the utility of conventional amplitude measurements of short-interval intracortical inhibition (A-SICI) with two threshold-tracking (T-SICI) methods, as aids to early diagnosis of amyotrophic lateral sclerosis (ALS). The new parallel threshold-tracking method (T-SICIp) was compared with the previously used serial tracking method (T-SICIs). Methods: 112 consecutive patients referred with the suspicion of ALS and 40 healthy controls were prospectively included. Based on clinical follow-up, patients were divided into 67 patients with motor neuron disease (MND) comprising progressive muscular atrophy (PMA) as well as ALS, and 45 patient controls. SICI was recorded from first dorsal interosseus muscle using the three different protocols. Results: MND patients had significantly reduced T-SICIp, T-SICIs and A-SICI, compared with healthy controls and patient controls, while healthy and patient controls were similar. Paradoxically, T-SICIp was least affected in MND patients with the most upper motor neuron (UMN) signs (Spearman ρ = 0.537, P

Published
2022
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