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6. A 4 tonne demonstrator for large-scale dual-phase liquid argon time projection chambers

Author

Aimard, B., Alt, Ch., Asaadi, J., Auger, M., Aushev, V., Autiero, D., Badoi, M. M., Balaceanu, A., Balik, G., Balleyguier, L., Bechetoille, E., Belver, D., Blebea-Apostu, A. M., Bolognesi, S., Bordoni, S., Bourgeois, N., Bourguille, B., Bremer, J., Brown, G., Brunetti, G., Brunetti, L., Caiulo, D., Calin, M., Calvo, E., Campanelli, M., Cankocak, K., Cantini, C., Carlus, B., Cautisanu, B. M., Chalifour, M., Chappuis, A., Charitonidis, N., Chatterjee, A., Chiriacescu, A., Chiu, P., Conforti, S., Cotte, P., Crivelli, P., Cuesta, C., Dawson, J., De Bonis, I., De La Taille, C., Delbart, A., Desforge, D., Di Luise, S., Dimitru, B. S., Doizon, F., Drancourt, C., Duchesneau, D., Dulucq, F., Dumarchez, J., Duval, F., Emery, S., Ereditato, A., Esanu, T., Falcone, A., Fusshoeller, K., Gallego-Ros, A., Galymov, V., Geroy, N., Gendotti, A., Gherghel-Lascu, M., Giganti, C., Gil-Botella, I., Girerd, C., Gomoiu, M. C., Gorodetzky, P., Hamada, E., Hanni, R., Hasegawa, T., Holin, A., Horikawa, S., Ikeno, M., Jimenez, S., Jipa, A., Karolak, M., Karyotakis, Y., Kasai, S., Kasami, K., Kishishita, T., Kreslo, I., Kryn, D., Lastoria, C., Lazanu, I., Lehmann-Miotto, G., Lira, N., Loo, K., Lorca, D., Lutz, P., Lux, T., Maalampi, J., Maire, G., Maki, M., Manenti, L., Margineanu, R. M., Marteau, J., Martin-Chassard, G., Mathez, H., Mazzucato, E., Misitano, G., Mitrica, B., Mladenov, D., Bueno, L. Molina, Martinez, C. Moreno, Mols, J. P., Mosu, T. S., Mug, W., Munteanu, A., Murphy, S., Nakayoshi, K., Narita, S., Navas-Nicolas, D., Negishi, K., Nessi, M., Niculescu-Oglinzanu, M., Nita, L., Noto, F., Noury, A., Onishchuk, Y., Palomares, C., Parvu, M., Patzak, T., Penichot, Y., Pennacchio, E., Periale, L., Pessard, H., Pietropaolo, F., Piret, Y., Popov, B., Pugnere, D., Radics, B., Redondo, D., Regenfus, C., Remoto, A., Resnati, F., Rigaut, Y. A., Ristea, C., Rubbia, A., Saftoiu, A., Sakashita, K., Sanchez, F., Santos, C., Scarpelli, A., Schloesser, C., Lavina, L. Scotto, Sendai, K., Sergiampietri, F., Shahsavarani, S., Shoji, M., Sinclair, J., Soto-Oton, J., Stanca, D. L., Stefan, D., Stroescu, P., Sulej, R., Tanaka, M., Toboaru, V., Tonazzo, A., Tromeur, W., Trzaska, W. H., Uchida, T., Vannucci, F., Vasseur, G., Verdugo, A., Viant, T., Vihonen, S., Vilalte, S., Weber, M., Wu, S., Yu, J., Zambelli, L., and Zito, M.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

A 10 kilo-tonne dual-phase liquid argon TPC is one of the detector options considered for the Deep Underground Neutrino Experiment (DUNE). The detector technology relies on amplification of the ionisation charge in ultra-pure argon vapour and oers several advantages compared to the traditional single-phase liquid argon TPCs. A 4.2 tonne dual-phase liquid argon TPC prototype, the largest of its kind, with an active volume of 3x1x1 $m^3$ has been constructed and operated at CERN. In this paper we describe in detail the experimental setup and detector components as well as report on the operation experience. We also present the first results on the achieved charge amplification, prompt scintillation and electroluminescence detection, and purity of the liquid argon from analyses of a collected sample of cosmic ray muons.

Published
2018
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7. Implementation of quark confinement, and retarded interactions algorithms for Chaos Many-Body Engine

Author

Grossu, I. V., Besliu, C., Jipa, Al., Felea, D., Stan, E., and Esanu, T.

Subjects
Physics - Computational Physics
Abstract

In Grossu et al. (2012) we presented a Chaos Many-Body Engine (CMBE) toy-model for chaos analysis of relativistic nuclear collisions at 4.5 A GeV/c (the SKM 200 collaboration) which was later extended to Cu + Cu collisions at the maximum BNL energy. Inspired by existing quark billiards, the main goal of this work was extending CMBE to partons. Thus, we first implemented a confinement algorithm founded on some intuitive assumptions: 1) the system can be decomposed into a set of two or three-body quark white clusters; 2) the bi-particle force is limited to the domain of each cluster; 3) the physical solution conforms to the minimum potential energy requirement. Color conservation was also treated as part of the reactions logic module. As an example of use, we proposed a toy-model for p + p collisions at sqrt(s)=10 GeV and we compared it with HIJING. Another direction of interest was related to retarded interactions. Following this purpose, we implemented an Euler retarded algorithm and we tested it on a simple two-body system with attractive inverse-square-law force. First results suggest that retarded interactions may contribute to the Virial theorem anomalies (dark matter) encountered for gravitational systems (e.g. clusters of galaxies). On the other hand, the time reverse functionality implemented in CMBE v03 could be used together with retardation for analyzing the Loschmidt paradox. Regarding the application design, it is important to mention the code was refactored to SOLID. In this context, we have also written more than one hundred unit and integration tests, which represent an important indicator of application logic validity., Comment: Submission to CPC in progress

Published
2017
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10. Enhancing Proton Radiosensitivity of Chondrosarcoma Using Nanoparticle-Based Drug Delivery Approaches: A Comparative Study of High- and Low-Energy Protons.

Author

Tudor, Mihaela, Popescu, Roxana Cristina, Irimescu, Ionela N., Rzyanina, Ann, Tarba, Nicolae, Dinischiotu, Anca, Craciun, Liviu, Esanu, Tiberiu Relu, Vasile, Eugeniu, Hotnog, Andrei Theodor, Radu, Mihai, Mytsin, Gennady, Mihailescu, Mona, and Savu, Diana Iulia

Subjects
LINEAR energy transfer, IRON oxide nanoparticles, CHEMICAL fingerprinting, SCANNING electron microscopy, COMPARATIVE method, GENETIC toxicology
Abstract

To overcome chondrosarcoma's (CHS) high chemo- and radioresistance, we used polyethylene glycol-encapsulated iron oxide nanoparticles (IONPs) for the controlled delivery of the chemotherapeutic doxorubicin (IONPDOX) to amplify the cytotoxicity of proton radiation therapy. Human 2D CHS SW1353 cells were treated with protons (linear energy transfer (LET): 1.6 and 12.6 keV/µm) with and without IONPDOX. Cell survival was assayed using a clonogenic test, and genotoxicity was tested through the formation of micronuclei (MN) and γH2AX foci, respectively. Morphology together with spectral fingerprints of nuclei were measured using enhanced dark-field microscopy (EDFM) assembled with a hyperspectral imaging (HI) module and an axial scanning fluorescence module, as well as scanning electron microscopy (SEM) coupled with energy-dispersive X-Ray spectroscopy (EDX). Cell survival was also determined in 3D SW3153 spheroids following treatment with low-LET protons with/without the IONPDOX compound. IONPDOX increased radiosensitivity following proton irradiation at both LETs in correlation with DNA damage expressed as MN or γH2AX. The IONPDOX–low-LET proton combination caused a more lethal effect compared to IONPDOX–high-LET protons. CHS cell biological alterations were reflected by the modifications in the hyperspectral images and spectral profiles, emphasizing new possible spectroscopic markers of cancer therapy effects. Our findings show that the proposed treatment combination has the potential to improve the management of CHS. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Magnetic Resonance Imaging of Temporomandibular Joint and Aortic Root Score in Fibrillinopathies.

Author

Moisii, Paloma, Naum, Alexandru Gratian, Ursu, Andra Mara, Vilcu, Adrian, Esanu, Irina, and Jari, Irina

Subjects
AORTIC root aneurysms, ANGIOTENSIN-receptor blockers, OPERATIVE dentistry, MAGNETIC resonance imaging, MARFAN syndrome, TEMPOROMANDIBULAR disorders
Abstract

Background and Objectives: Fibrillinopathies have different phenotypic expression: Marfan-like skeleton features, MLSF; mitral valve prolapse syndrome, MVPS; MASS phenotype, M = mitral valve prolapse, MVP, A = aortic root dilation, S = skeletal features, and the second S = (cutaneous) striae; Marfan Syndrome, MS. The study had the following main objectives: the correlation between disc displacement, DD (a major sign for temporomandibular joint dysfunction, TMDs) on magnetic resonance imaging, MRI, and aortic Z score (a major sign for aortic root dilation) on echocardiography; the predictive value of DD towards aortic Z score. DD had 2 types of severity: DD with reduction (the mild type, DDwR), and DD without reduction (the severe type, DDwoR). Materials and Methods: The type of fibrillinopathy was precised by clinical exam (systemic score), ophthalmic exam (for ectopia lentis), and echocardiography (aortic Z score, MVP). Medical treatment consisted of betablockers, BB (for patients with tachycardia), or angiotensin II receptor blockers, ARB. Surgical treatment was addressed to aortic root aneurysm, and severe mitral regurgitation, MR. DD benefited from dental conservatory treatment or surgical restoration. Results: DD-Z score had a powerful correlation in MASS (Rho = 0.787, p < 0.01), and in MS patients (Rho = 0.819, p < 0.01). For the entire sample, both DDwR-Z score and DDwoR-Z score had a moderate correlation (Rho = 0.469, and respectively 0.669). Furthermore, DD was an important predictor for Z score. DDwoR had a double power of prediction for the Z score compared with DDwR (B coefficient = 1.661 for DDwR and 3.281 for DDwoR). Conclusions: TMDs had a powerful correlation with aortic root dilation in MASS and MS patients from the sample. Likewise, TMDs was a major predictor for aortic root dilation, in the entire sample. In clinical practice, we can utilize an extracardiac finding, TMDs, obtained by a non-invasive technique, MRI, for cardiac severity stratification of fibrillinopathies. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Electrochemical evaluation of proton beam radiation effect on the B16 cell culture

Author

Melania Onea, Mihaela Bacalum, Andreea Luminita Radulescu, Mina Raileanu, Liviu Craciun, Tiberiu Relu Esanu, and Teodor Adrian Enache

Subjects
Medicine, Science
Abstract

Abstract The interaction of radiation with matter takes place through energy transfer and is accomplished especially by ionized atoms or molecules. The effect of radiation on biological systems involves multiple physical, chemical and biological steps. Direct effects result in a large number of reactive oxygen species (ROS) within and outside and inside of the cells as well, which are responsible for oxidative stress. Indirect effects are defined as alteration of normal biological processes and cellular components (DNA, protein, lipids, etc.) caused by the reactive oxygen species directly induced by radiation. In this work, a classical design of an electrochemical (EC) three-electrodes system was employed for analyzing the effects of proton beam radiation on melanoma B16 cell line. In order to investigate the effect of proton radiation on the B16 cells, the cells were grown on the EC surface and irradiated. After optimization of the experimental set-up and dosimetry, the radiobiological experiments were performed at doses ranging between 0 and 2 Gy and the effect of proton beam irradiation on the cells was evaluated by the means of cyclic voltammetry and measuring the open circuit potential between working and reference electrodes.

Published
2022
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13. Correlation between echocardiographic parameters of left ventricle and glycosylated hemoglobin in children with type 1 Diabetes Mellitus

Author

Valeriu ESANU and Ina PALII

Subjects
children, diabetes mellitus, left ventricle, glycosylated hemoglobin, Medicine, Science
Abstract

Introduction. Deterioration of left ventricular (LV) parameters in Diabetes Mellitus (DM) can occur in the absence of other heart problems. An association between glycosylated hemoglobin (HbA1c) and changes of the LV parameters in DM has been reported. However, data regarding this association model in children with Type 1 Diabetes Mellitus (T1DM) are limited. The purpose of the work was to investigate the association between HbA1c and the LV parameters in pediatric patients. Material and methods. The study was conducted on 28 children with T1DM ((aged 10 - 18 years, gender M (15)/F (13), duration ≥5 years). The clinical (standard medical examination) and paraclinical (biochemical dosage – HbA1c, echocardiography – LV functional and structural parameters) data was carried out. Statistical analysis used the SPSS version 20. Results. The correlational study between the HbA1c and the LV parameters revealed a statistically significant positive correlation coefficient with aortic root diameter (mm) (r=0.7**, p

Published
2022
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14. Challenges in QCD matter physics - The Compressed Baryonic Matter experiment at FAIR

Author

CBM Collaboration, Ablyazimov, T., Abuhoza, A., Adak, R. P., Adamczyk, M., Agarwal, K., Aggarwal, M. M., Ahammed, Z., Ahmad, F., Ahmad, N., Ahmad, S., Akindinov, A., Akishin, P., Akishina, E., Akishina, T., Akishina, V., Akram, A., Al-Turany, M., Alekseev, I., Alexandrov, E., Alexandrov, I., Amar-Youcef, S., Anđelić, M., Andreeva, O., Andrei, C., Andronic, A., Anisimov, Yu., Appelshäuser, H., Argintaru, D., Atkin, E., Avdeev, S., Averbeck, R., Azmi, M. D., Baban, V., Bach, M., Badura, E., Bähr, S., Balog, T., Balzer, M., Bao, E., Baranova, N., Barczyk, T., Bartoş, D., Bashir, S., Baszczyk, M., Batenkov, O., Baublis, V., Baznat, M., Becker, J., Becker, K. -H., Belogurov, S., Belyakov, D., Bendarouach, J., Berceanu, I., Bercuci, A., Berdnikov, A., Berdnikov, Y., Berendes, R., Berezin, G., Bergmann, C., Bertini, D., Bertini, O., Beşliu, C., Bezshyyko, O., Bhaduri, P. P., Bhasin, A., Bhati, A. K., Bhattacharjee, B., Bhattacharyya, A., Bhattacharyya, T. K., Biswas, S., Blank, T., Blau, D., Blinov, V., Blume, C., Bocharov, Yu., Book, J., Breitner, T., Brüning, U., Brzychczyk, J., Bubak, A., Büsching, H., Bus, T., Butuzov, V., Bychkov, A., Byszuk, A., Cai, Xu, Cálin, M., Cao, Ping, Caragheorgheopol, G., Carević, I., Cătănescu, V., Chakrabarti, A., Chattopadhyay, S., Chaus, A., Chen, Hongfang, Chen, LuYao, Cheng, Jianping, Chepurnov, V., Cherif, H., Chernogorov, A., Ciobanu, M. I., Claus, G., Constantin, F., Csanád, M., D'Ascenzo, N., Das, Supriya, Das, Susovan, de Cuveland, J., Debnath, B., Dementiev, D., Deng, Wendi, Deng, Zhi, Deppe, H., Deppner, I., Derenovskaya, O., Deveaux, C. A., Deveaux, M., Dey, K., Dey, M., Dillenseger, P., Dobyrn, V., Doering, D., Dong, Sheng, Dorokhov, A., Dreschmann, M., Drozd, A., Dubey, A. K., Dubnichka, S., Dubnichkova, Z., Dürr, M., Dutka, L., Dželalija, M., Elsha, V. V., Emschermann, D., Engel, H., Eremin, V., Eşanu, T., Eschke, J., Eschweiler, D., Fan, Huanhuan, Fan, Xingming, Farooq, M., Fateev, O., Feng, Shengqin, Figuli, S. P. D., Filozova, I., Finogeev, D., Fischer, P., Flemming, H., Förtsch, J., Frankenfeld, U., Friese, V., Friske, E., Fröhlich, I., Frühauf, J., Gajda, J., Galatyuk, T., Gangopadhyay, G., Chávez, C. García, Gebelein, J., Ghosh, P., Ghosh, S. K., Gläßel, S., Goffe, M., Golinka-Bezshyyko, L., Golovatyuk, V., Golovnya, S., Golovtsov, V., Golubeva, M., Golubkov, D., Ramírez, A. Gómez, Gorbunov, S., Gorokhov, S., Gottschalk, D., Gryboś, P., Grzeszczuk, A., Guber, F., Gudima, K., Gumiński, M., Gupta, A., Gusakov, Yu., Han, Dong, Hartmann, H., He, Shue, Hehner, J., Heine, N., Herghelegiu, A., Herrmann, N., Heß, B., Heuser, J. M., Himmi, A., Höhne, C., Holzmann, R., Hu, Dongdong, Huang, Guangming, Huang, Xinjie, Hutter, D., Ierusalimov, A., Ilgenfritz, E. -M., Irfan, M., Ivanischev, D., Ivanov, M., Ivanov, P., Ivanov, Valery, Ivanov, Victor, Ivanov, Vladimir, Ivashkin, A., Jaaskelainen, K., Jahan, H., Jain, V., Jakovlev, V., Janson, T., Jiang, Di, Jipa, A., Kadenko, I., Kähler, P., Kämpfer, B., Kalinin, V., Kallunkathariyil, J., Kampert, K. -H., Kaptur, E., Karabowicz, R., Karavichev, O., Karavicheva, T., Karmanov, D., Karnaukhov, V., Karpechev, E., Kasiński, K., Kasprowicz, G., Kaur, M., Kazantsev, A., Kebschull, U., Kekelidze, G., Khan, M. M., Khan, S. A., Khanzadeev, A., Khasanov, F., Khvorostukhin, A., Kirakosyan, V., Kirejczyk, M., Kiryakov, A., Kiš, M., Kisel, I., Kisel, P., Kiselev, S., Kiss, T., Klaus, P., Kłeczek, R., Klein-Bösing, Ch., Kleipa, V., Klochkov, V., Kmon, P., Koch, K., Kochenda, L., Koczoń, P., Koenig, W., Kohn, M., Kolb, B. W., Kolosova, A., Komkov, B., Korolev, M., Korolko, I., Kotte, R., Kovalchuk, A., Kowalski, S., Koziel, M., Kozlov, G., Kozlov, V., Kramarenko, V., Kravtsov, P., Krebs, E., Kreidl, C., Kres, I., Kresan, D., Kretschmar, G., Krieger, M., Kryanev, A. V., Kryshen, E., Kuc, M., Kucewicz, W., Kucher, V., Kudin, L., Kugler, A., Kumar, Ajit, Kumar, Ashwini, Kumar, L., Kunkel, J., Kurepin, A., Kurepin, N., Kurilkin, A., Kurilkin, P., Kushpil, V., Kuznetsov, S., Kyva, V., Ladygin, V., Lara, C., Larionov, P., García, A. Laso, Lavrik, E., Lazanu, I., Lebedev, A., Lebedev, S., Lebedeva, E., Lehnert, J., Lehrbach, J., Leifels, Y., Lemke, F., Li, Cheng, Li, Qiyan, Li, Xin, Li, Yuanjing, Lindenstruth, V., Linnik, B., Liu, Feng, Lobanov, I., Lobanova, E., Löchner, S., Loizeau, P. -A., Lone, S. A., Martínez, J. A. Lucio, Luo, Xiaofeng, Lymanets, A., Lyu, Pengfei, Maevskaya, A., Mahajan, S., Mahapatra, D. P., Mahmoud, T., Maj, P., Majka, Z., Malakhov, A., Malankin, E., Malkevich, D., Malyatina, O., Malygina, H., Mandal, M. M., Mandal, S., Manko, V., Manz, S., Garcia, A. M. Marin, Markert, J., Masciocchi, S., Matulewicz, T., Meder, L., Merkin, M., Mialkovski, V., Michel, J., Miftakhov, N., Mik, L., Mikhailov, K., Mikhaylov, V., Milanović, B., Militsija, V., Miskowiec, D., Momot, I., Morhardt, T., Morozov, S., Müller, W. F. J., Müntz, C., Mukherjee, S., Castillo, C. E. Muńoz, Murin, Yu., Najman, R., Nandi, C., Nandy, E., Naumann, L., Nayak, T., Nedosekin, A., Negi, V. S., Niebur, W., Nikulin, V., Normanov, D., Oancea, A., Oh, Kunsu, Onishchuk, Yu., Ososkov, G., Otfinowski, P., Ovcharenko, E., Pal, S., Panasenko, I., Panda, N. R., Parzhitskiy, S., Patel, V., Pauly, C., Penschuck, M., Peshekhonov, D., Peshekhonov, V., Petráček, V., Petri, M., Petriş, M., Petrovici, A., Petrovici, M., Petrovskiy, A., Petukhov, O., Pfeifer, D., Piasecki, K., Pieper, J., Pietraszko, J., Płaneta, R., Plotnikov, V., Plujko, V., Pluta, J., Pop, A., Pospisil, V., Poźniak, K., Prakash, A., Prasad, S. K., Prokudin, M., Pshenichnov, I., Pugach, M., Pugatch, V., Querchfeld, S., Rabtsun, S., Radulescu, L., Raha, S., Rami, F., Raniwala, R., Raniwala, S., Raportirenko, A., Rautenberg, J., Rauza, J., Ray, R., Razin, S., Reichelt, P., Reinecke, S., Reinefeld, A., Reshetin, A., Ristea, C., Ristea, O., Rodriguez, A. Rodriguez, Roether, F., Romaniuk, R., Rost, A., Rostchin, E., Rostovtseva, I., Roy, Amitava, Roy, Ankhi, Rożynek, J., Ryabov, Yu., Sadovsky, A., Sahoo, R., Sahu, P. K., Sahu, S. K., Saini, J., Samanta, S., Sambyal, S. S., Samsonov, V., Rosado, J. Sánchez, Sander, O., Sarangi, S., Satława, T., Sau, S., Saveliev, V., Schatral, S., Schiaua, C., Schintke, F., Schmidt, C. J., Schmidt, H. R., Schmidt, K., Scholten, J., Schweda, K., Seck, F., Seddiki, S., Selyuzhenkov, I., Semennikov, A., Senger, A., Senger, P., Shabanov, A., Shabunov, A., Shao, Ming, Sheremetiev, A. D., Shi, Shusu, Shumeiko, N., Shumikhin, V., Sibiryak, I., Sikora, B., Simakov, A., Simon, C., Simons, C., Singaraju, R. N., Singh, A. K., Singh, B. K., Singh, C. P., Singhal, V., Singla, M., Sitzmann, P., Siwek-Wilczyńska, K., Škoda, L., Skwira-Chalot, I., Som, I., Song, Guofeng, Song, Jihye, Sosin, Z., Soyk, D., Staszel, P., Strikhanov, M., Strohauer, S., Stroth, J., Sturm, C., Sultanov, R., Sun, Yongjie, Svirida, D., Svoboda, O., Szabó, A., Szczygieł, R., Talukdar, R., Tang, Zebo, Tanha, M., Tarasiuk, J., Tarassenkova, O., Târzilă, M. -G., Teklishyn, M., Tischler, T., Tlustý, P., Tölyhi, T., Toia, A., Topil'skaya, N., Träger, M., Tripathy, S., Tsakov, I., Tsyupa, Yu., Turowiecki, A., Tuturas, N. G., Uhlig, F., Usenko, E., Valin, I., Varga, D., Vassiliev, I., Vasylyev, O., Verbitskaya, E., Verhoeven, W., Veshikov, A., Visinka, R., Viyogi, Y. P., Volkov, S., Volochniuk, A., Vorobiev, A., Voronin, Aleksey, Voronin, Alexander, Vovchenko, V., Vznuzdaev, M., Wang, Dong, Wang, Xi-Wei, Wang, Yaping, Wang, Yi, Weber, M., Wendisch, C., Wessels, J. P., Wiebusch, M., Wiechula, J., Wielanek, D., Wieloch, A., Wilms, A., Winckler, N., Winter, M., Wiśniewski, K., Wolf, Gy., Won, Sanguk, Wu, Ke-Jun, Wüstenfeld, J., Xiang, Changzhou, Xu, Nu, Yang, Junfeng, Yang, Rongxing, Yin, Zhongbao, Yoo, In-Kwon, Yuldashev, B., Yushmanov, I., Zabołotny, W., Zaitsev, Yu., Zamiatin, N. I., Zanevsky, Yu., Zhalov, M., Zhang, Yifei, Zhang, Yu, Zhao, Lei, Zheng, Jiajun, Zheng, Sheng, Zhou, Daicui, Zhou, Jing, Zhu, Xianglei, Zinchenko, A., Zipper, W., Żoładź, M., Zrelov, P., Zryuev, V., Zumbruch, P., and Zyzak, M.

Subjects
Nuclear Experiment
Abstract

Substantial experimental and theoretical efforts worldwide are devoted to explore the phase diagram of strongly interacting matter. At LHC and top RHIC energies, QCD matter is studied at very high temperatures and nearly vanishing net-baryon densities. There is evidence that a Quark-Gluon-Plasma (QGP) was created at experiments at RHIC and LHC. The transition from the QGP back to the hadron gas is found to be a smooth cross over. For larger net-baryon densities and lower temperatures, it is expected that the QCD phase diagram exhibits a rich structure, such as a first-order phase transition between hadronic and partonic matter which terminates in a critical point, or exotic phases like quarkyonic matter. The discovery of these landmarks would be a breakthrough in our understanding of the strong interaction and is therefore in the focus of various high-energy heavy-ion research programs. The Compressed Baryonic Matter (CBM) experiment at FAIR will play a unique role in the exploration of the QCD phase diagram in the region of high net-baryon densities, because it is designed to run at unprecedented interaction rates. High-rate operation is the key prerequisite for high-precision measurements of multi-differential observables and of rare diagnostic probes which are sensitive to the dense phase of the nuclear fireball. The goal of the CBM experiment at SIS100 (sqrt(s_NN) = 2.7 - 4.9 GeV) is to discover fundamental properties of QCD matter: the phase structure at large baryon-chemical potentials (mu_B > 500 MeV), effects of chiral symmetry, and the equation-of-state at high density as it is expected to occur in the core of neutron stars. In this article, we review the motivation for and the physics programme of CBM, including activities before the start of data taking in 2022, in the context of the worldwide efforts to explore high-density QCD matter., Comment: 15 pages, 11 figures. Published in European Physical Journal A

Published
2016
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15. Left ventricular remodeling patterns in children with metabolic syndrome

Author

Veronica ESANU, Ina PALII, Veronica MOCANU, Lorina VUDU, and Valeriu ESANU

Subjects
metabolic syndrome, children, left ventricular remodeling, patterns, Medicine, Science
Abstract

Introduction. Pathological left ventricular (LV) remodelling in children with metabolic syndrome (MS) is associated with a significant increase in cardiometabolic risk. However, data regarding the prevalence of LV remodelling patterns in children with MS are limited. Material and methods. An observational analytical cohort study was conducted on 145 children. The diagnosis of MS was established according to the International Diabetes Federation (IDF) criteria. We analyzed the echocardiography, as well as clinical and paraclinical data. Participants were distributed, depending on LV mass index and relative wall thickness into four LV geometric patterns as recommended by American and European Society of Echocardiography: normal geometry, concentric left ventricular remodeling (cLVR), concentric left ventricular hypertrophy (cLVH), and eccentric left ventricular hypertrophy (eLVH). Results. The pathological remodeling patterns were distributed as follows: 62.1% (n=90) participants showed a normal LV geometry pattern, 27.6% (n=40) – cLVH, 5.5% (n=8) – cLVR and 4.8% (n=7) – eLVH. In terms of presence/absence of MS, 54.7% (n=29) participants from the research group showed a normal LV geometry pattern, 32.1% (n=17) – cLVH, 5.7% (n=3) – cLVR and 7.5% (n=4) – eLVH, whereas 66.3% (n=61) participants from the control group presented normal LV geometric appearance, 25% (n=23) – cLVH, 5.4% (n=5) – cLVR and 3.3% (n=3) – eLVR (χ2=0.52; p>0.05). Conclusions. Concentric left ventricular hypertrophy was the commonest LV geometric pattern among the subjects with metabolic syndrome. Concentric left ventricular remodelling and eccentric left ventricular hypertrophy were rare among the study population.

Published
2020
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18. Mimesis, Expression, Construction: Fredric Jameson’s Seminar on Aesthetic Theory

Author

Frederic Jameson, Octavian Esanu, Frederic Jameson, and Octavian Esanu

Abstract

Mimesis, Expression, Construction brings Fredric Jameson’s famous Duke University seminar on Adorno’s Aesthetic Theory into print for the first time. Transcribed and edited from audio recordings taken by Octavian Esanu of the original seminar at Duke University in 2003, Mimesis, Expression, Construction reproduces Jameson and his students’ engagement with Aesthetic Theory, one of the most influential theories of modernist aesthetics. The first and only published record of Jameson’s teaching and pedagogic style, the seminar delves into modern and modernist aesthetics through the perspectives of Kant, Hegel, Freud, Schopenhauer, and Nietzsche; Benjamin and other members of the Frankfurt School; the literary works of Thomas Mann and Samuel Beckett; the music of Schoenberg, Webern and Berg; the films of Chaplin, Vertov and Eisenstein; the aesthetic implications of psychoanalysis and biblical exegesis; classical music; and more. Presented in the format of a play, with stage setting, student interruptions and exchanges, interjections, auditory noises, and ambient sounds, and complemented with scans of students’ notes, Mimesis, Expression, Construction is a groundbreaking addition to the work of one of the greatest modern cultural critics., https://www.librarystack.org/mimesis-expression-construction-fredric-jamesons-seminar-on-aesthetic-theory/?ref=unknown

Published
2024

19. e-flux Index #1

Author

George MacBeth, Brian Kuan Wood, Anton Vidokle, Julieta Aranda, Nikolaus Hirsch, Nick Axel, Christina Moushoul, Ben Eastham, Patrick Langley, Francesca Wade, Juliana Halpert, Aaron Schuster, Mike Andrews, Remco van Bladel, Sixing Xu, Jason Read, Peter Sealy, Jacinda S. Tran, Manuel Borja-Villel, Vasif Kortun, Yuriko Furuhata, Xinyue Liu, Boris Groys, Zdenka Badovinac, Christian Nyampeta, Feza Kayungu Ramazani, Iago Bojczuk, Nicole Starosielski, Serubiri Moses, Nkule Mabaso, Pietro Bianchi, Sonia D’Alto, Jennifer Piejko, Sami Khatib, Oxana Timofeeva, Jenny Wu, Sandra Neugärtner, Novuyo Moyo, Matteo Pasquinelli, Jason E. Smith, R. H. Lossin, Nathan Brown, Evan Calder Williams, Christoph Menke, Kim Förster, Stephanie Bailey, Laila Seewang, Aziba Ekio, Michael Kurtz, Dorota Jagoda Michalska, Judith Wilkinson, Kate Sutton, Artemy Magun, Paul Stephens, Tausif Noor, Octavian Esanu, Angela Harutyunyan, Olexii Kuchanskyi, David Morris, Valentin Diaconov, Gracie Hadland, Katherine Adams, Hans Ulrich Obrist, Ikko Kobayashi, Fumi Kashimura, Jose Rosales, Jörg Heiser, Christ Mukenge, Lydia Schellhammer, Sorana Schellhammer, George MacBeth, Brian Kuan Wood, Anton Vidokle, Julieta Aranda, Nikolaus Hirsch, Nick Axel, Christina Moushoul, Ben Eastham, Patrick Langley, Francesca Wade, Juliana Halpert, Aaron Schuster, Mike Andrews, Remco van Bladel, Sixing Xu, Jason Read, Peter Sealy, Jacinda S. Tran, Manuel Borja-Villel, Vasif Kortun, Yuriko Furuhata, Xinyue Liu, Boris Groys, Zdenka Badovinac, Christian Nyampeta, Feza Kayungu Ramazani, Iago Bojczuk, Nicole Starosielski, Serubiri Moses, Nkule Mabaso, Pietro Bianchi, Sonia D’Alto, Jennifer Piejko, Sami Khatib, Oxana Timofeeva, Jenny Wu, Sandra Neugärtner, Novuyo Moyo, Matteo Pasquinelli, Jason E. Smith, R. H. Lossin, Nathan Brown, Evan Calder Williams, Christoph Menke, Kim Förster, Stephanie Bailey, Laila Seewang, Aziba Ekio, Michael Kurtz, Dorota Jagoda Michalska, Judith Wilkinson, Kate Sutton, Artemy Magun, Paul Stephens, Tausif Noor, Octavian Esanu, Angela Harutyunyan, Olexii Kuchanskyi, David Morris, Valentin Diaconov, Gracie Hadland, Katherine Adams, Hans Ulrich Obrist, Ikko Kobayashi, Fumi Kashimura, Jose Rosales, Jörg Heiser, Christ Mukenge, Lydia Schellhammer, and Sorana Schellhammer

Abstract

e-flux Index is a bimonthly publishing project that synthesizes two months’ worth of contributions from the five separate sections of the e-flux publishing enterprise, from e-flux Architecture, e-flux Criticism, e-flux Education, e-flux journal, and e-flux Notes respectively. Each of these sections has its own independent editorial agenda as well as publishing temporality. This first issue presents the pieces published by e-flux in December 2023 and January 2024. The metadata gives some indication of its breadth, spanning 48 pieces, 52 authors, and over 150,000 words. Following its wider editorial ambitions to co-articulate multiple discourses, the Index removes the identity cards anchoring these pieces to their original provenance, and instead “meta-edits” them into nine emergent thematic strands., https://www.librarystack.org/e-flux-index-1/?ref=unknown

Published
2024

20. The LBNO long-baseline oscillation sensitivities with two conventional neutrino beams at different baselines

Author

Collaboration, LAGUNA-LBNO, Agarwalla, S. K., Agostino, L., Aittola, M., Alekou, A., Andrieu, B., Antoniou, F., Asfandiyarov, R., Autiero, D., Bésida, O., Balik, A., Ballett, P., Bandac, I., Banerjee, D., Bartmann, W., Bay, F., Biskup, B., Blebea-Apostu, A. M., Blondel, A., Bogomilov, M., Bolognesi, S., Borriello, E., Brancus, I., Bravar, A., Buizza-Avanzini, M., Caiulo, D., Calin, M., Calviani, M., Campanelli, M., Cantini, C., Cata-Danil, G., Chakraborty, S., Charitonidis, N., Chaussard, L., Chesneanu, D., Chipesiu, F., Crivelli, P., Dawson, J., De Bonis, I., Declais, Y., Sanchez, P. Del Amo, Delbart, A., Di Luise, S., Duchesneau, D., Dumarchez, J., Efthymiopoulos, I., Eliseev, A., Emery, S., Enqvist, T., Enqvist, K., Epprecht, L., Erykalov, A. N., Esanu, T., Franco, D., Friend, M., Galymov, V., Gavrilov, G., Gendotti, A., Giganti, C., Gilardoni, S., Goddard, B., Gomoiu, C. M., Gornushkin, Y. A., Gorodetzky, P., Haesler, A., Hasegawa, T., Horikawa, S., Huitu, K., Izmaylov, A., Jipa, A., Kainulainen, K., Karadzhov, Y., Khabibullin, M., Khotjantsev, A., Kopylov, A. N., Korzenev, A., Kosyanenko, S., Kryn, D., Kudenko, Y., Kuusiniemi, P., Lazanu, I., Lazaridis, C., Levy, J. -M., Loo, K., Maalampi, J., Margineanu, R. M., Marteau, J., Martin-Mari, C., Matveev, V., Mazzucato, E., Mefodiev, A., Mineev, O., Mirizzi, A., Mitrica, B., Murphy, S., Nakadaira, T., Narita, S., Nesterenko, D. A., Nguyen, K., Nikolics, K., Noah, E., Novikov, Yu., Oprima, A., Osborne, J., Ovsyannikova, T., Papaphilippou, Y., Pascoli, S., Patzak, T., Pectu, M., Pennacchio, E., Periale, L., Pessard, H., Popov, B., Ravonel, M., Rayner, M., Resnati, F., Ristea, O., Robert, A., Rubbia, A., Rummukainen, K., Saftoiu, A., Sakashita, K., Sanchez-Galan, F., Sarkamo, J., Saviano, N., Scantamburlo, E., Sergiampietri, F., Sgalaberna, D., Shaposhnikova, E., Slupecki, M., Smargianaki, D., Stanca, D., Steerenberg, R., Sterian, A. R., Sterian, P., Stoica, S., Strabel, C., Suhonen, J., Suvorov, V., Toma, G., Tonazzo, A., Trzaska, W. H., Tsenov, R., Tuominen, K., Valram, M., Vankova-Kirilova, G., Vannucci, F., Vasseur, G., Velotti, F., Velten, P., Venturi, V., Viant, T., Vihonen, S., Vincke, H., Vorobyev, A., Weber, A., Wu, S., Yershov, N., Zambelli, L., and Zito, M.

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment
Abstract

The proposed Long Baseline Neutrino Observatory (LBNO) initially consists of $\sim 20$ kton liquid double phase TPC complemented by a magnetised iron calorimeter, to be installed at the Pyh\"asalmi mine, at a distance of 2300 km from CERN. The conventional neutrino beam is produced by 400 GeV protons accelerated at the SPS accelerator delivering 700 kW of power. The long baseline provides a unique opportunity to study neutrino flavour oscillations over their 1st and 2nd oscillation maxima exploring the $L/E$ behaviour, and distinguishing effects arising from $\delta_{CP}$ and matter. In this paper we show how this comprehensive physics case can be further enhanced and complemented if a neutrino beam produced at the Protvino IHEP accelerator complex, at a distance of 1160 km, and with modest power of 450 kW is aimed towards the same far detectors. We show that the coupling of two independent sub-MW conventional neutrino and antineutrino beams at different baselines from CERN and Protvino will allow to measure CP violation in the leptonic sector at a confidence level of at least $3\sigma$ for 50\% of the true values of $\delta_{CP}$ with a 20 kton detector. With a far detector of 70 kton, the combination allows a $3\sigma$ sensitivity for 75\% of the true values of $\delta_{CP}$ after 10 years of running. Running two independent neutrino beams, each at a power below 1 MW, is more within today's state of the art than the long-term operation of a new single high-energy multi-MW facility, which has several technical challenges and will likely require a learning curve., Comment: 21 pages, 12 figures

Published
2014

21. Optimised sensitivity to leptonic CP violation from spectral information: the LBNO case at 2300 km baseline

Author

Collaboration, LAGUNA-LBNO, Agarwalla, S. K., Agostino, L., Aittola, M., Alekou, A., Andrieu, B., Antoniou, F., Asfandiyarov, R., Autiero, D., Bésida, O., Balik, A., Ballett, P., Bandac, I., Banerjee, D., Bartmann, W., Bay, F., Biskup, B., Blebea-Apostu, A. M., Blondel, A., Bogomilov, M., Bolognesi, S., Borriello, E., Brancus, I., Bravar, A., Buizza-Avanzini, M., Caiulo, D., Calin, M., Calviani, M., Campanelli, M., Cantini, C., Cata-Danil, G., Chakraborty, S., Charitonidis, N., Chaussard, L., Chesneanu, D., Chipesiu, F., Crivelli, P., Dawson, J., De Bonis, I., Declais, Y., Sanchez, P. Del Amo, Delbart, A., Di~Luise, S., Duchesneau, D., Dumarchez, J., Efthymiopoulos, I., Eliseev, A., Emery, S., Enqvist, T., Enqvist, K., Epprecht, L., Erykalov, A. N., Esanu, T., Franco, D., Friend, M., Galymov, V., Gavrilov, G., Gendotti, A., Giganti, C., Gilardoni, S., Goddard, B., Gomoiu, C. M., Gornushkin, Y. A., Gorodetzky, P., Haesler, A., Hasegawa, T., Horikawa, S., Huitu, K., Izmaylov, A., Jipa, A., Kainulainen, K., Karadzhov, Y., Khabibullin, M., Khotjantsev, A., Kopylov, A. N., Korzenev, A., Kosyanenko, S., Kryn, D., Kudenko, Y., Kuusiniemi, P., Lazanu, I., Lazaridis, C., Levy, J. -M., Loo, K., Maalampi, J., Margineanu, R. M., Marteau, J., Martin-Mari, C., Matveev, V., Mazzucato, E., Mefodiev, A., Mineev, O., Mirizzi, A., Mitrica, B., Murphy, S., Nakadaira, T., Narita, S., Nesterenko, D. A., Nguyen, K., Nikolics, K., Noah, E., Novikov, Yu., Oprima, A., Osborne, J., Ovsyannikova, T., Papaphilippou, Y., Pascoli, S., Patzak, T., Pectu, M., Pennacchio, E., Periale, L., Pessard, H., Popov, B., Ravonel, M., Rayner, M., Resnati, F., Ristea, O., Robert, A., Rubbia, A., Rummukainen, K., Saftoiu, A., Sakashita, K., Sanchez-Galan, F., Sarkamo, J., Saviano, N., Scantamburlo, E., Sergiampietri, F., Sgalaberna, D., Shaposhnikova, E., Slupecki, M., Smargianaki, D., Stanca, D., Steerenberg, R., Sterian, A. R., Sterian, P., Stoica, S., Strabel, C., Suhonen, J., Suvorov, V., Toma, G., Tonazzo, A., Trzaska, W. H., Tsenov, R., Tuominen, K., Valram, M., Vankova-Kirilova, G., Vannucci, F., Vasseur, G., Velotti, F., Velten, P., Venturi, V., Viant, T., Vihonen, S., Vincke, H., Vorobyev, A., Weber, A., Wu, S., Yershov, N., Zambelli, L., and Zito, M.

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment
Abstract

One of the main goals of the Long Baseline Neutrino Observatory (LBNO) is to study the $L/E$ behaviour (spectral information) of the electron neutrino and antineutrino appearance probabilities, in order to determine the unknown CP-violation phase $\delta_{CP}$ and discover CP-violation in the leptonic sector. The result is based on the measurement of the appearance probabilities in a broad range of energies, covering t he 1st and 2nd oscillation maxima, at a very long baseline of 2300 km. The sensitivity of the experiment can be maximised by optimising the energy spectra of the neutrino and anti-neutrino fluxes. Such an optimisation requires exploring an extended range of parameters describing in details the geometries and properties of the primary protons, hadron target and focusing elements in the neutrino beam line. In this paper we present a numerical solution that leads to an optimised energy spectra and study its impact on the sensitivity of LBNO to discover leptonic CP violation. In the optimised flux both 1st and 2nd oscillation maxima play an important role in the CP sensitivity. The studies also show that this configuration is less sensitive to systematic errors (e.g. on the total event rates) than an experiment which mainly relies on the neutrino-antineutrino asymmetry at the 1st maximum to determine the existence of CP-violation., Comment: 25 pages, 20 figures

Published
2014

23. LBNO-DEMO: Large-scale neutrino detector demonstrators for phased performance assessment in view of a long-baseline oscillation experiment

Author

Agostino, L., Andrieu, B., Asfandiyarov, R., Autiero, D., Bésida, O., Bay, F., Bayes, R., Blebea-Apostu, A. M., Blondel, A., Bogomilov, M., Bolognesi, S., Bordoni, S., Bravar, A., Buizza-Avanzini, M., Cadoux, F., Caiulo, D., Calin, M., Campanelli, M., Cantini, C., Chaussard, L., Chesneanu, D., Colino, N., Crivelli, P., De Bonis, I., Déclais, Y., Dawson, J., De La Taille, C., Sanchez, P. Del Amo, Delbart, A., Di Luise, S., Duchesneau, D., Dulucq, F., Dumarchez, J., Efthymiopoulos, I., Emery, S., Enqvist, T., Epprecht, L., Esanu, T., Franco, D., Friend, M., Galymov, V., Gendotti, A., Giganti, C., Gil-Botella, I., Gomoiu, M. C, Gorodetzky, P., Haesler, A., Hasegawa, T., Horikawa, S., Ieva, M., Jipa, A., Karadzhov, Y., Karpikov, I., Khotjantsev, A., Korzenev, A., Kryn, D., Kudenko, Y., Kuusiniemi, P., Lazanu, I., Levy, J. -M., Loo, K., Lux, T., Maalampi, J., Margineanu, R. M., Marteau, J., Martin, C., Martin-Chassard, G., Mazzucato, E., Mefodiev, A., Mineev, O., Mitrica, B., Murphy, S., Nakadaira, T., Nessi, M., Nikolics, K., Nita, L., Noah, E., Novella, P., Nuijten, G. A., Ovsiannikova, T., Palomares, C., Patzak, T., Pennacchio, E., Periale, L., Pessard, H., Popov, B., Ravonel, M., Rayner, M., Regenfus, C., Ristea, C., Ristea, O., Robert, A., Rubbia, A., Sakashita, K., Sanchez, F., Santorelli, R., Scantamburlo, E., Sergiampietri, F., Sgalaberna, D., Slupecki, M., Soler, F. J. P., Stanca, D. L., Tonazzo, A., Trzaska, W. H., Tsenov, R., Vankova-Kirilova, G., Vannucci, F., Vasseur, G., Verdugo, A., Viant, T., Wu, S., Yershov, N., Zambelli, L., and Zito, M.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

In June 2012, an Expression of Interest for a long-baseline experiment (LBNO) has been submitted to the CERN SPSC. LBNO considers three types of neutrino detector technologies: a double-phase liquid argon (LAr) TPC and a magnetised iron detector as far detectors. For the near detector, a high-pressure gas TPC embedded in a calorimeter and a magnet is the baseline design. A mandatory milestone is a concrete prototyping effort towards the envisioned large-scale detectors, and an accompanying campaign of measurements aimed at assessing the detector associated systematic errors. The proposed $6\times 6\times 6$m$^3$ DLAr is an industrial prototype of the design discussed in the EoI and scalable to 20 kton or 50~kton. It is to be constructed and operated in a controlled laboratory and surface environment with test beam access, such as the CERN North Area (NA). Its successful operation and full characterisation will be a fundamental milestone, likely opening the path to an underground deployment of larger detectors. The response of the DLAr demonstrator will be measured and understood with an unprecedented precision in a charged particle test beam (0.5-20 GeV/c). The exposure will certify the assumptions and calibrate the response of the detector, and allow to develop and to benchmark sophisticated reconstruction algorithms, such as those of 3-dimensional tracking, particle ID and energy flow in liquid argon. All these steps are fundamental for validating the correctness of the physics performance described in the LBNO EoI., Comment: 217 pages, 164 figures, LBNO-DEMO (CERN WA105) Collaboration

Published
2014

25. The mass-hierarchy and CP-violation discovery reach of the LBNO long-baseline neutrino experiment

Author

Collaboration, LAGUNA-LBNO, Agarwalla, S. K., Agostino, L., Aittola, M., Alekou, A., Andrieu, B., Angus, D., Antoniou, F., Ariga, A., Ariga, T., Asfandiyarov, R., Autiero, D., Ballett, P., Bandac, I., Banerjee, D., Barker, G. J., Barr, G., Bartmann, W., Bay, F., Berardi, V., Bertram, I., Bésida, O., Blebea-Apostu, A. M., Blondel, A., Bogomilov, M., Borriello, E., Boyd, S., Brancus, I., Bravar, A., Buizza-Avanzini, M., Cafagna, F., Calin, M., Calviani, M., Campanelli, M., Cantini, C., Caretta, O., Cata-Danil, G., Catanesi, M. G., Cervera, A., Chakraborty, S., Chaussard, L., Chesneanu, D., Chipesiu, F., Christodoulou, G., Coleman, J., Crivelli, P., Davenne, T., Dawson, J., De Bonis, I., De Jong, J., Déclais, Y., Sanchez, P. Del Amo, Delbart, A., Densham, C., Di Lodovico, F., Di Luise, S., Duchesneau, D., Dumarchez, J., Efthymiopoulos, I., Eliseev, A., Emery, S., Enqvist, K., Enqvist, T., Epprecht, L., Ereditato, A., Erykalov, A. N., Esanu, T., Finch, A. J., Fitton, M. D., Franco, D., Galymov, V., Gavrilov, G., Gendotti, A., Giganti, C., Goddard, B., Gomez, J. J., Gomoiu, C. M., Gornushkin, Y. A., Gorodetzky, P., Grant, N., Haesler, A., Haigh, M. D., Hasegawa, T., Haug, S., Hierholzer, M., Hissa, J., Horikawa, S., Huitu, K., Ilic, J., Ioannisian, A. N., Izmaylov, A., Jipa, A., Kainulainen, K., Kalliokoski, T., Karadzhov, Y., Kawada, J., Khabibullin, M., Khotjantsev, A., Kokko, E., Kopylov, A. N., Kormos, L. L., Korzenev, A., Kosyanenko, S., Kreslo, I., Kryn, D., Kudenko, Y., Kudryavtsev, V. A., Kumpulainen, J., Kuusiniemi, P., Lagoda, J., Lazanu, I., Levy, J. -M., Litchfield, R. P., Loo, K., Loveridge, P., Maalampi, J., Magaletti, L., Margineanu, R. M., Marteau, J., Martin-Mari, C., Matveev, V., Mavrokoridis, K., Mazzucato, E., McCauley, N., Mercadante, A., Mineev, O., Mirizzi, A., Mitrica, B., Morgan, B., Murdoch, M., Murphy, S., Mursula, K., Narita, S., Nesterenko, D. A., Nguyen, K., Nikolics, K., Noah, E., Novikov, Yu., O'Keeffe, H., Odell, J., Oprima, A., Palladino, V., Papaphilippou, Y., Pascoli, S., Patzak, T., Payne, D., Pectu, M., Pennacchio, E., Periale, L., Pessard, H., Pistillo, C., Popov, B., Przewlocki, P., Quinto, M., Radicioni, E., Ramachers, Y., Ratoff, P. N., Ravonel, M., Rayner, M., Resnati, F., Ristea, O., Robert, A., Rondio, E., Rubbia, A., Rummukainen, K., Sacco, R., Saftoiu, A., Sakashita, K., Sarkamo, J., Sato, F., Saviano, N., Scantamburlo, E., Sergiampietri, F., Sgalaberna, D., Shaposhnikova, E., Slupecki, M., Sorel, M., Spooner, N. J. C., Stahl, A., Stanca, D., Steerenberg, R., Sterian, A. R., Sterian, P., Still, B., Stoica, S., Strauss, T., Suhonen, J., Suvorov, V., Szeptycka, M., Terri, R., Thompson, L. F., Toma, G., Tonazzo, A., Touramanis, C., Trzaska, W. H., Tsenov, R., Tuominen, K., Vacheret, A., Valram, M., Vankova-Kirilova, G., Vanucci, F., Vasseur, G., Velotti, F., Velten, P., Viant, T., Vincke, H., Virtanen, A., Vorobyev, A., Wark, D., Weber, A., Weber, M., Wiebusch, C., Wilson, J. R., Wu, S., Yershov, N., Zalipska, J., and Zito, M.

Subjects
High Energy Physics - Phenomenology
Abstract

The next generation neutrino observatory proposed by the LBNO collaboration will address fundamental questions in particle and astroparticle physics. The experiment consists of a far detector, in its first stage a 20 kt LAr double phase TPC and a magnetised iron calorimeter, situated at 2300 km from CERN and a near detector based on a high-pressure argon gas TPC. The long baseline provides a unique opportunity to study neutrino flavour oscillations over their 1st and 2nd oscillation maxima exploring the $L/E$ behaviour, and distinguishing effects arising from $\delta_{CP}$ and matter. In this paper we have reevaluated the physics potential of this setup for determining the mass hierarchy (MH) and discovering CP-violation (CPV), using a conventional neutrino beam from the CERN SPS with a power of 750 kW. We use conservative assumptions on the knowledge of oscillation parameter priors and systematic uncertainties. The impact of each systematic error and the precision of oscillation prior is shown. We demonstrate that the first stage of LBNO can determine unambiguously the MH to $>5\sigma$C.L. over the whole phase space. We show that the statistical treatment of the experiment is of very high importance, resulting in the conclusion that LBNO has $\sim$ 100% probability to determine the MH in at most 4-5 years of running. Since the knowledge of MH is indispensable to extract $\delta_{CP}$ from the data, the first LBNO phase can convincingly give evidence for CPV on the $3\sigma$C.L. using today's knowledge on oscillation parameters and realistic assumptions on the systematic uncertainties., Comment: 35 pages, 22 figures, added authors

Published
2013

33. Compulsory admissions of patients with mental disorders: State of the art on ethical and legislative aspects in 40 European countries

Author

D. Wasserman, G. Apter, C. Baeken, S. Bailey, J. Balazs, C. Bec, P. Bienkowski, J. Bobes, M. F. Bravo Ortiz, H. Brunn, Ö. Bôke, N. Camilleri, B. Carpiniello, J. Chihai, E. Chkonia, P. Courtet, D. Cozman, M. David, G. Dom, A. Esanu, P. Falkai, W. Flannery, K. Gasparyan, G. Gerlinger, P. Gorwood, O. Gudmundsson, C. Hanon, A. Heinz, M. J. Heitor Dos Santos, A. Hedlund, F. Ismayilov, N. Ismayilov, E. T. Isometsä, L. Izakova, A. Kleinberg, T. Kurimay, S. Klæbo Reitan, D. Lecic-Tosevski, A. Lehmets, N. Lindberg, K. A. Lundblad, G. Lynch, C. Maddock, U.F. Malt, L. Martin, I. Martynikhin, N. O. Maruta, F. Matthys, R. Mazaliauskiene, G. Mihajlovic, A. Mihaljevic Peles, V. Miklavic, P. Mohr, M. Munarriz Ferrandis, M. Musalek, N. Neznanov, G. Ostorharics-Horvath, I. Pajević, A. Popova, P. Pregelj, E. Prinsen, C. Rados, A. Roig, M. Rojnic Kuzman, J. Samochowiec, N. Sartorius, Y. Savenko, O. Skugarevsky, E. Slodecki, A. Soghoyan, D. S. Stone, R. Taylor-East, E. Terauds, C. Tsopelas, C. Tudose, S. Tyano, P. Vallon, R. J. Van der Gaag, P. Varandas, L. Vavrusova, P. Voloshyn, J. Wancata, J. Wise, Z. Zemishlany, F. Öncü, and S. Vahip

Subjects
Awareness, communication, compulsory admission, education, ethics and human rights, European Psychiatric Association (EPA), involuntary admission, legal model, medical model, National Psychiatric Associations (NPAs), psychiatry in Europe, stigma, Psychiatry, RC435-571
Abstract

AbstractBackground.Compulsory admission procedures of patients with mental disorders vary between countries in Europe. The Ethics Committee of the European Psychiatric Association (EPA) launched a survey on involuntary admission procedures of patients with mental disorders in 40 countries to gather information from all National Psychiatric Associations that are members of the EPA to develop recommendations for improving involuntary admission processes and promote voluntary care.Methods.The survey focused on legislation of involuntary admissions and key actors involved in the admission procedure as well as most common reasons for involuntary admissions.Results.We analyzed the survey categorical data in themes, which highlight that both medical and legal actors are involved in involuntary admission procedures.Conclusions.We conclude that legal reasons for compulsory admission should be reworded in order to remove stigmatization of the patient, that raising awareness about involuntary admission procedures and patient rights with both patients and family advocacy groups is paramount, that communication about procedures should be widely available in lay-language for the general population, and that training sessions and guidance should be available for legal and medical practitioners. Finally, people working in the field need to be constantly aware about the ethical challenges surrounding compulsory admissions.

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35. Code C# for chaos analysis of relativistic many-body systems with reactions

Author

Grossu, I. V., Besliu, C., Jipa, Al., Stan, E., Esanu, T., Felea, D., and Bordeianu, C. C.

Subjects
Physics - Computational Physics, Nonlinear Sciences - Chaotic Dynamics, Nuclear Theory
Abstract

In this work we present a reactions module for "Chaos Many-Body Engine" (Grossu et al., 2010 [1]). Following our goal of creating a customizable, object oriented code library, the list of all possible reactions, including the corresponding properties (particle types, probability, cross-section, particles lifetime etc.), could be supplied as parameter, using a specific XML input file. Inspired by the Poincare section, we propose also the "Clusterization map", as a new intuitive analysis method of many-body systems. For exemplification, we implemented a numerical toy-model for nuclear relativistic collisions at 4.5 A GeV/c (the SKM200 collaboration). An encouraging agreement with experimental data was obtained for momentum, energy, rapidity, and angular {\pi}- distributions.

Published
2010
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36. Visual tool for estimating the fractal dimension of images

Author

Grossu, I. V., Besliu, C., Rusu, M. V., Jipa, Al., Bordeianu, C. C., Felea, D., Stan, E., and Esanu, T.

Subjects
Physics - Computational Physics, Computer Science - Graphics, Nonlinear Sciences - Pattern Formation and Solitons
Abstract

This work presents a new Visual Basic 6.0 application for estimating the fractal dimension of images, based on an optimized version of the box-counting algorithm. Following the attempt to separate the real information from noise, we considered also the family of all band-pass filters with the same band-width (specified as parameter). The fractal dimension can be thus represented as a function of the pixel color code. The program was used for the study of paintings cracks, as an additional tool which can help the critic to decide if an artistic work is original or not. In its second version, the application was extended for working also with csv files and three-dimensional images., Comment: A new version was accepted to Computer Physics Communications doi:10.1016/j.cpc.2009.12.005

Published
2009
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37. Analysis of cognitive status during rehabilitation after hip arthroplasty associated with pre-existing knee arthroplasty on the same leg: Case Presentation.

Author

Chicu, Mihaiela, Esanu, Irina, Mihailov, Liliana, Onofrei, Bianca Andreea, and Matran-Dan, Madalina Ioana

Subjects
*HEMIARTHROPLASTY, *TOTAL hip replacement, *COGNITIVE analysis, *FEMORAL neck fractures, *ARTHROPLASTY, *HIP fractures, *PHYSICAL medicine
Abstract

Introduction: Hip arthroplasty conducted through either cemented or cementless prostheses must alleviate pain and restore joint mobility and muscle strength. The main goal is to restore mobility, stability and to maintain ADL (Activities of Daily Living) within normal parameters. Current surgical techniques allow for state-of-the-art surgeries to be performed. Yet, the postoperative course is strongly influenced by both pre-and postoperative psychological factors, as well as by associated diseases. Materials and Methods: We present the case of a 79-year-old female patient from Iasi, a retired yet still physically active gym teacher who was admitted an emergency to the Orthopedics Clinic of the "Sf. Spiridon" Emergency Hospital with a displaced left femoral neck fracture resulting from samelevel fall. The patient had for 6 years a Scorpio-Stryker cemented knee prosthesis on the same leg. Through surgical intervention, a cementless bipolar Lépine prosthesis was inserted into the left hip. Then, the patient presented to the Department of Physical Medicine and Rehabilitation of the Iasi Clinical Railroad Hospital to receive an adequate post-operative rehabilitation program. Results: The psychosocial factors have been analyzed with the help of various recent and specialized psychological scales. The obtained results confirm the fact that these factors significantly influence the rehabilitation of prosthesis-wearing patients. Conclusion: Our study emphasizes the psychological impact on standing and walking rehabilitation in a patient with two prostheses on the same motor axis. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Low back pain-Algorithm of diagnosis and management.

Author

Chicu, Mihaiela, Matran-Dan, Madalina Ioana, Esanu, Irina, Mihailov, Liliana, and Onofrei, Bianca Andreea

Subjects
CHRONIC pain, LUMBAR pain, DIAGNOSIS, DIFFERENTIAL diagnosis
Abstract

Introduction: Low back pain is a frequent condition, associated as a symptom with a multitude of organic or non-organic pathologies, resulting in the appearance of disability generating negative economic and soc-professional consequences. Being a relatively common symptom among patients, we created this paper with the aim to high-light the importance of the clinical examination along with the correct direction of the patient to a profile depart-ment, the review of differential diagnoses, as well as the establishment of a particular recovery plan adapted to each case. Materials and Methods: We analyzed a series of recent articles using the PubMed and the Cochrane Library data-bases, using the keywords words "low back pain" and "rehabilitation", to obtain data on the clinical and paraclinical examination, positive and differential diagnosis of chronic low back pain, as well as on rehabilitation management. Results: Low back pain may appear due to vertebral conditions (inflammatory, infectious, traumatic, neoplastic, degenerative, metabolic), or due to extravertebral causes. Along with the anamnesis, clinical examination and im-agistic investigations, we establish the positive diagnosis and create an individualised rehabilitation plan. The reha-bilitation protocol is divided into stages, the final goal is to minimize the ischemia-pain-contracture chain. Conclusion: The pathology of the lumbosacral spine can be characterized by the word "diversity", being one of the causes of early disability of the population in the field of work. Our work highlights the importance of the clinical and paraclinical examination in outlining the differential diagnosis of chronic lumbar pain, as well as the role of the multidisciplinary team in complex individualized rehabilitation treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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41. Code C# for chaos analysis of relativistic many-body systems

Author

Grossu, I. V., Besliu, C., Jipa, Al., Felea, D., Bordeianu, C. C., Stan, E., and Esanu, T.

Subjects
Physics - Computational Physics, High Energy Physics - Phenomenology, Nonlinear Sciences - Chaotic Dynamics
Abstract

This work presents a new Microsoft Visual C# .NET code library, conceived as a general object oriented solution for chaos analysis of three-dimensional, relativistic many-body systems. In this context, we implemented the Lyapunov exponent and the "fragmentation level" (defined using the graph theory and the Shannon entropy). Inspired by existing studies on billiard nuclear models and clusters of galaxies, we tried to apply the virial theorem for a simplified many-body system composed by nucleons. A possible application of the "virial coefficient" to the stability analysis of chaotic systems is also discussed.

Published
2008
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42. Value of the Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Predicting CPET Performance in Patients with Stable CAD and Recent Elective PCI

Author

Andrei Drugescu, Mihai Roca, Ioana Mădălina Zota, Alexandru-Dan Costache, Oana Irina Gavril, Radu Sebastian Gavril, Teodor Flaviu Vasilcu, Ovidiu Mitu, Irina Mihaela Esanu, Iulia-Cristina Roca, Cristina Mihaela Ghiciuc, and Florin Mitu

Subjects
functional capacity, platelet to lymphocyte ratio, neutrophil to lymphocyte ratio, cardiopulmonary exercise test, oxygen uptake, coronary artery disease, Medicine (General), R5-920
Abstract

Background and Objectives: Functional capacity (FC) assessed via cardiopulmonary exercise testing (CPET) is a novel, independent prognostic marker for patients with coronary artery disease (CAD). Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) are two readily available predictors of systemic inflammation and cardiovascular event risk, which could be used as cost-effective predictors of poor FC. The purpose of this study was to evaluate the utility of NLR and PLR in predicting poor FC in patients with CAD and recent elective percutaneous coronary intervention (PCI). Materials and Methods: Our cross-sectional retrospective analysis included 80 patients with stable CAD and recent elective PCI (mean age 55.51 ± 11.83 years, 71.3% male) who were referred to a cardiovascular rehabilitation center from January 2020 to June 2021. All patients underwent clinical examination, cardiopulmonary exercise testing on a cycle ergometer, transthoracic echocardiography and standard blood analysis. Results: Patients were classified according to percent predicted oxygen uptake (% VO2 max) in two groups—poor FC (≤70%, n = 35) and preserved FC (>70%, n = 45). There was no significant difference between groups regarding age, gender ratio, presence of associated comorbidities, left ventricular ejection fraction and NLR. PLR was higher in patients with poor FC (169.8 ± 59.3 vs. 137.4 ± 35.9, p = 0.003). A PLR cut-off point of 139 had 74% sensitivity and 60% specificity in predicting poor FC. After multivariate analysis, PLR remained a significant predictor of poor functional status. Conclusions: Although CPET is the gold standard test for assessing FC prior to cardiovascular rehabilitation, its availability remains limited. PLR, a cheap and simple test, could predict poor FC in patients with stable CAD and recent elective PCI and help prioritize referral for cardiovascular rehabilitation in high-risk patients.

Published
2022
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48. Study of strange particle pT spectra in heavy-ion collisions at relativistic energies.

Author

Ristea, Oana, Ristea, Catalin, Jipa, Alexandru, Calin, Marius, and Esanu, Tiberiu

Subjects
QUANTUM chromodynamics, PHASE diagrams, CROSSOVER trials, TEMPERATURE, RESONANCE
Abstract

The transverse momentum distributions of strange and multi-strange hadrons produced in most central Au+Au collisions at RHIC-BES energies were studied using the Boltzmann-Gibbs blast-wave model. The energy dependence of the kinetic freeze-out parameters is presented and discussed. [ABSTRACT FROM AUTHOR]

Published
2023
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49. Acute and Long-Term Consequences of COVID-19 on Arterial Stiffness—A Narrative Review

Author

Ioana Mădălina Zota, Cristian Stătescu, Radu Andy Sascău, Mihai Roca, Larisa Anghel, Alexandra Maștaleru, Maria Magdalena Leon-Constantin, Cristina Mihaela Ghiciuc, Sebastian Romica Cozma, Lucia Corina Dima-Cozma, Irina Mihaela Esanu, and Florin Mitu

Subjects
SARS-CoV-2, COVID-19, arterial stiffness, pulse wave velocity, cardiovascular risk, endotheliitis, Science
Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the ongoing global coronavirus (COVID-19) pandemic. Although initially viewed as an acute respiratory illness, COVID-19 is clearly a complex multisystemic disease with extensive cardiovascular involvement. Emerging evidence shows that the endothelium plays multiple roles in COVID-19 physiopathology, as both a target organ that can be directly infected by SARS-CoV-2 and a mediator in the subsequent inflammatory and thrombotic cascades. Arterial stiffness is an established marker of cardiovascular disease. The scope of this review is to summarize available data on the acute and long-term consequences of COVID-19 on vascular function. COVID-19 causes early vascular aging and arterial stiffness. Fast, noninvasive bedside assessment of arterial stiffness could optimize risk stratification in acute COVID-19, allowing for early escalation of treatment. Vascular physiology remains impaired at least 12 months after infection with SARS-CoV-2, even in otherwise healthy adults. This raises concerns regarding the extent of arterial remodeling in patients with preexisting vascular disease and the potential development of a persistent, chronic COVID-19 vasculopathy. Long-term follow up on larger cohorts is required to investigate the reversibility of COVID-19-induced vascular changes and their associated prognostic implications.

Published
2022
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50. Liver Steatosis and its Implications in Patients with Chronic Viral Hepatitis C

Author

Oana Irina Gavril, Irina Mihaela Esanu, Otilia Gavrilescu, Raluca Popa, Maria Luiza Cobzeanu, Diana Tatarciuc, Teodor Vasilcu, Andrei Drugescu, Radu Sebastian Gavril, and Florin Mitu

Subjects
General Medicine
Abstract

Introduction. Hepatic steatosis represents a common pathological feature in patients with chronic viral C infection and can be independently associated with obesity, increased alcohol consumption, type 2 diabetes, and hyperlipidemia. These factors can contribute to the development of hepatic steatosis in patients with chronic HCV (Hepatitis C virus) infection. Materials and methods. 64 patients who underwent treatment with oral antivirals were included and evaluated through non-invasive methods for the degree of hepatic steatosis. Results. After at least 3 months of sustained viral response, all patients with advanced hepatic steatosis were categorized into lower classes in the Steatotest evaluation. Conclusion. This study highlights the importance of direct acting antiviral (DAA) treatment in the medical care of patients with chronic viral C infection and hepatic steatosis. Thirty years after the discovery of the hepatitis C virus, treatment with oral antivirals revolutionizes the medical care of patients with this chronic infection.

Published
2023

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